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Professor : Otaka, Akira |
| ○ | 生物有機化学, 有機合成化学, ペプチド・タンパク質化学, ケミカルバイオロジー |
| ○ | 創薬基盤確立に向けた効率的なタンパク質化学合成法の開拓 |
| 1. | Akira Otaka : 「4章 『失敗の言語化』が拓いたリバイバル研究」ドラマチック有機合成化学 感動の瞬間100 (有機合成化学協会 編), Kagaku-Dojin Publishing Company,INC, Jul. 2023. |
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| 2. | Akira Otaka : 「1章 現場で必要な臨床医薬品化学とは，6章 糖尿病とその治療薬」現場で役に立つ!臨床医薬品化学 (臨床医薬品化学研究会 編), Kagaku-Dojin Publishing Company,INC, Apr. 2021. |
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| 3. | Akira Otaka and Akira Shigenaga : 「第I編 ペプチド合成，第二章 ペプチドの液相合成」医療・診断をささえるペプチド科学―再生医療・DDS・診断への応用―(平野義明 監修), CMC Publishing Co.,Ltd., Oct. 2017. |
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| 4. | Akira Shigenaga, Jun Yamamoto and Akira Otaka : 実験医学増刊号 驚愕の代謝システム メタボロームの階層から解き明かす疾患研究の新たなステージ「生物活性小分子の結合パートナータンパク質を知りたい -リンカー分子を用いたタンパク質精製法-」, YODOSHA CO., LTD., Sep. 2014. |
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| 5. | Akira Otaka : 生体有機化学 第12章 生理活性ペプチドホルモン, Tokyo Kagaku Dozin C., Ltd., Oct. 2012. |
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| 6. | Akira Shigenaga, Jun Yamamoto and Akira Otaka : 遺伝子医学MOOK 21号 最新ペプチド合成技術とその創薬研究への応用, 刺激応答型アミノ酸の開発と生命科学分野への応用, メディカルドゥ, Apr. 2012. |
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| 7. | Akira Otaka and Akira Shigenaga : 機能性タンパク質・ペプチドの生体利用，第10章 最近のペプチド・タンパク質の化学合成について, KENPAKUSHA, May 2010. |
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| 8. | Akira Otaka : 新しい薬をどう創るか, Kodansha, Tokyo, Apr. 2007. |
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| 9. | Akira Otaka : タンパク質化学 第11巻, 株式会社 廣川書店, Tokyo, 1997. |
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| 10. | 藤井 信孝 and Akira Otaka : 新生化学実験講座1 タンパク質6, Tokyo Kagaku Dozin C., Ltd., Tokyo, Jun. 1992. |
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| 11. | 木曽 良明 and Akira Otaka : 続 医薬品の開発 第14巻, 株式会社 廣川書店, Tokyo, 1991. |
| 1. | Tsuji Takashi, Hayato INAZUKI, Kobayashi Daishiro, Hayashi JUNYA, Masaya Denda and Akira Otaka : Cysteinylprolyl ester-mediated drug release from a lipid-drug conjugate, Bioorganic & Medicinal Chemistry Letters, Vol.109, 129850, 2024. (Tokushima University Institutional Repository: 119452, DOI: 10.1016/j.bmcl.2024.129850, PubMed: 38879090, Elsevier: Scopus) |
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| 2. | Daishiro Kobayashi, Masaya Denda, Junya Hayashi, Kohta Hidaka, Yutaka Kohmura, Takaaki Tsunematsu, Kohei Nishino, Harunori Yoshikawa, OHKAWACHI Kento, Kiyomi Nigorikawa, Tetsuro Yoshimaru, Naozumi Ishimaru, Wataru Nomura, Toyomasa Katagiri, Hidetaka Kosako and Akira Otaka : Sulfoxide-Mediated Cys-Trp-Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization, ChemistryEurope, Vol.2, No.3-4, 2024. (DOI: 10.1002/ceur.202400014) |
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| 3. | Junya Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka : Late-stage formation of a sactionine linkage enabled by Lossen rearrangement of glycyl hydroxamic acid, Organic Letters, Vol.26, No.24, 5167-5171, 2024. (Tokushima University Institutional Repository: 119421, DOI: 10.1021/acs.orglett.4c01685, PubMed: 38848136, Elsevier: Scopus) |
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| 4. | Junya Hayashi, Daishiro Kobayashi, Chizuru Namikawa, Masaya Denda and Akira Otaka : Synthesis of N-Glyoxylyl Peptides Enabled by a Lossen Rearrangement-Induced Intramolecular Redox Reaction of N-Terminal Glycyl Hydroxamic Acid, Organic Letters, Vol.26, No.20, 4246-4250, 2024. (Tokushima University Institutional Repository: 119346, DOI: 10.1021/acs.orglett.4c01126, PubMed: 38738629) |
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| 5. | Kohta Hidaka, Daishiro Kobayashi, Junya Hayashi, Masaya Denda and Akira Otaka : Advanced Insulin Synthesis by One-pot/Stepwise Disulfide Bond Formation Enabled by S-Protected Cysteine Sulfoxide, Chemistry - A European Journal, Vol.30, No.39, e202401003, 2024. (Tokushima University Institutional Repository: 119333, DOI: 10.1002/chem.202401003, PubMed: 38683139) |
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| 6. | Rin Miyajima, Kosuke Tanegashima, Naoto Naruse, Masaya Denda, Takahiro Hara and Akira Otaka : Identification of Low-Density Lipoprotein Receptor-Related Protein 1 as a CXCL14 Receptor Using Chemically Synthesized Tetrafunctional Probes, ACS Chemical Biology, Vol.19, No.2, 551-562, 2024. (DOI: 10.1021/acschembio.3c00717, PubMed: 38289037) |
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| 7. | Masaki Imanishi, Takahisa Inoue, Keijo Fukushima, Ryosuke Yamashita, Ryo Nakayama, Masataka Nojima, Kosuke Kondo, Yoshiki Gomi, Honoka Tsunematsu, Kohei Goto, Licht Miyamoto, Masafumi Funamoto, Masaya Denda, Keisuke Ishizawa, Akira Otaka, Hiromichi Fujino, Yasumasa Ikeda and Koichiro Tsuchiya : CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses., Journal of Pharmacological Sciences, Vol.153, No.4, 232-242, 2023. (Tokushima University Institutional Repository: 119176, DOI: 10.1016/j.jphs.2023.10.003, PubMed: 37973221, CiNii: 1050018428980929664) |
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| 8. | Takashi Tsuji, Honoka Tsunematsu, Masaki Imanishi, Masaya Denda, Koichiro Tsuchiya and Akira Otaka : Enhanced tumor specific drug release by hypoxia sensitive dual-prodrugs based on 2-nitroimidazole, Bioorganic & Medicinal Chemistry Letters, 129484, 2023. (DOI: 10.1016/j.bmcl.2023.129484, PubMed: 37716415) |
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| 9. | OHKAWACHI Kento, Kaito Anzaki, Daishiro Kobayashi, Ryuji Kyan, Takuma Yasuda, Masaya Denda, Norio Harada, Akira Shigenaga, Nobuya Inagaki and Akira Otaka : Residue-selective CH sulfenylation enabled by acid-activated S-acetamidomethyl cysteine sulfoxide with application to one-pot stapling and lipidation sequence, Chemistry - A European Journal, Vol.29, No.26, e202300799, 2023. (Tokushima University Institutional Repository: 118080, DOI: 10.1002/chem.202300799, PubMed: 36922350, CiNii: 1360861705587936000) |
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| 10. | Misaki Yamasaki, Yuika Seto, Mizune Ohzono, Michiyasu Nakao, Akira Shigenaga, Akira Otaka, Shigeki Sano and Kentaro Kogure : Development of a novel tocopheryl ester for suppression of lipid accumulation without cytotoxicity by optimization of dicarboxylic ester moiety, Biochemistry and Biophysics Reports, Vol.31, 101329, 2022. (Tokushima University Institutional Repository: 117361, DOI: 10.1016/j.bbrep.2022.101329) |
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| 11. | Daishiroh Kobayashi, KURAOKA Eisuke, Junya Hayashi, Takuma Yasuda, Yutaka Kohmura, Masaya Denda, Norio Harada, Nobuya Inagaki and Akira Otaka : S-Protected cysteine sulfoxide-enabled tryptophan-selective modification with application to peptide lipidation, ACS Medicinal Chemistry Letters, Vol.13, No.7, 1125-1130, 2022. (Tokushima University Institutional Repository: 117175, DOI: 10.1021/acsmedchemlett.2c00161) |
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| 12. | Masato Miyake, Mitsuaki Sobajima, Kiyoe Kurahashi, Akira Shigenaga, Masaya Denda, Akira Otaka, Tomohide Saio, Naoki Sakane, Hidetaka Kosako and Seiichi Oyadomari : Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells., Cell Chemical Biology, Vol.29, No.6, 996-1009.e9, 2022. (Tokushima University Institutional Repository: 116761, DOI: 10.1016/j.chembiol.2022.01.002, PubMed: 35143772) |
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| 13. | Daiki Sato, Masaya Denda, Honoka Tsunematsu, Naonobu Tanaka, Isamu Konishi, Chiaki Komiya, Akira Shigenaga and Akira Otaka : Late-stage macrolactonisation enabled by tandem acyl transfers followed by desulphurisation, Chemical Communications, Vol.58, No.17, 2918-2921, 2022. (Tokushima University Institutional Repository: 116717, DOI: 10.1039/D1CC07248J, PubMed: 35138311) |
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| 14. | Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda, Koichiro Tsuchiya and Akira Otaka : Copper (II)-mediated C-H sulphenylation or selenylation of tryptophan enabling macrocyclization of peptides, Chemical Communications, Vol.57, 10763-10766, 2021. (Tokushima University Institutional Repository: 116325, DOI: 10.1039/D1CC04856B, PubMed: 34585682) |
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| 15. | Daishiroh Kobayashi, Yutaka Kohmura, Toshihiko Sugiki, Eisuke Kuraoka, Masaya Denda, Toshimichi Fujiwara and Akira Otaka : Peptide Cyclization Mediated by Metal-Free S-Arylation: S-Protected Cysteine Sulfoxide as an Umpolung of Cysteine Nucleophile, Chemistry - A European Journal, Vol.27, No.56, 14092-14099, 2021. (Tokushima University Institutional Repository: 116324, DOI: 10.1002/chem.202102420) |
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| 16. | Rina Iwase, Naoto Naruse, Miho Nakagawa, Risa Saito, Akira Shigenaga, Akira Otaka, Takahiko Hara and Kosuke Tanegashima : Identification of Functional Domains of CXCL14 Involved in High-Affinity Binding and Intracellular Transport of CpG DNA, The Journal of Immunology, Vol.207, No.2, 459-469, 2021. (DOI: 10.4049/jimmunol.2100030) |
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| 17. | Jan Vincent V. Arafiles, Hisaaki Hirose, Yusuke Hirai, Masashi Kuriyama, Maxwell Mamfe Sakyiamah, Wataru Nomura, Kazuhiro Sonomura, Miki Imanishi, Akira Otaka, Hirokazu Tamamura and Shiroh Futaki : Discovery of a Macropinocytosis-Inducing Peptide Potentiated byMedium-Mediated Intramolecular Disulfide Formation, Angewandte Chemie International Edition, Vol.60, No.21, 11928-11936, 2021. (DOI: 10.1002/anie.202016754) |
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| 18. | Masahiro Ueda, Chiaki Komiya, Sayuki Arii, Kohshi Kusumoto, Masaya Denda, Keiichiro Okuhira, Akira Shigenaga and Akira Otaka : Sequence-independent traceless method for preparation of peptide/protein thioesters using CPaseY-mediated hydrazinolysis, Chemical & Pharmaceutical Bulletin, Vol.68, No.12, 1226-1232, 2020. (DOI: 10.1248/cpb.c20-00674, PubMed: 33028801) |
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| 19. | Daishiroh Kobayashi, Naoto Naruse, Masaya Denda, Akira Shigenaga and Akira Otaka : Deprotection of S-Acetamidomethyl Cysteine with Copper (II) and 1,2-Aminothiols under Aerobic Conditions, Organic & Biomolecular Chemistry, Vol.18, 8638-8645, 2020. (Tokushima University Institutional Repository: 115115, DOI: 10.1039/D0OB01475C) |
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| 20. | Kento Ohkawachi, Daishiroh Kobayashi, Kyohei Morimoto, Akira Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai and Akira Otaka : Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in Peptide/Protein Synthesis, Organic Letters, Vol.22, No.14, 5289-5293, 2020. (Tokushima University Institutional Repository: 114733, DOI: 10.1021/acs.orglett.0c01383, PubMed: 32396369) |
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| 21. | Naoto Naruse, Daishiroh Kobayashi, Kento Ohkawachi, Akira Shigenaga and Akira Otaka : Copper-mediated deprotection of thiazolidine and selenazolidine derivatives applied to native chemical ligation, The Journal of Organic Chemistry, Vol.85, No.3, 1425-1433, 2020. (DOI: 10.1021/acs.joc.9b02388) |
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| 22. | Atsushi Nakayama, Akira Ohtani, Tsubasa Inokuma, Daisuke Tsuji, Haruka Mukaiyama, Nakayama Akira, Kouji Itou, Akira Otaka, Tanino Keiji and Kosuke Namba : Development of a 1,3a,6a-triazapentalene derivatives as a compact and thiol-specific fluorescent labeling reagent, Communications Chemistry, Vol.3, 6, 2020. (Tokushima University Institutional Repository: 115071, DOI: 10.1038/s42004-019-0250-0, Elsevier: Scopus) |
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| 23. | Tsubasa Inokuma, Takuya Sakakibara, Takatoshi Someno, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : Asymmetric Synthesis of α-Amino Phosphonic Acids Using Stable Imino Phosphonate as a Universal Precursor, Chemistry - A European Journal, Vol.25, 2019. (Tokushima University Institutional Repository: 115143, DOI: 10.1002/chem.201903572, Elsevier: Scopus) |
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| 24. | Chiaki Komiya, Akira Shigenaga, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Kouji Itou and Akira Otaka : Traceless synthesis of protein thioesters using enzyme-mediated hydrazinolysis and subsequent self-editing of cysteinyl prolyl sequence, Chemical Communications, Vol.55, 7029-7032, 2019. (Tokushima University Institutional Repository: 113348, DOI: 10.1039/C9CC03583D, PubMed: 31140482, Elsevier: Scopus) |
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| 25. | Haruka Kawahara, Naoki Miyashita, Kohki Tachibana, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira : A photo-activatable peptide mimicking functions of apolipoprotein A-I, Biological & Pharmaceutical Bulletin, Vol.42, No.6, 1019-1024, 2019. (DOI: 10.1248/bpb.b19-00114, PubMed: 31155576, Elsevier: Scopus) |
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| 26. | Takuya Morisaki, Akira Shigenaga and Akira Otaka : Development of a turn-on fluorescent traceable linker employing N-sulfanylethylcoumarinyl amide for enrichment and visualization of target proteins Current Topic Drug Discovery: Recent Progress and the Future, Chemical & Pharmaceutical Bulletin, Vol.68, No.3, 216-219, 2019. (DOI: 10.1248/cpb.c19-00726) |
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| 27. | Takahisa Jichu, Tsubasa Inokuma, Keisuke Aihara, Taiki Kohiki, Kohdai Nishida, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka : A recyclable hydrophobic anchor-tagged asymmetric amino thiourea catalyst, ChemCatChem, Vol.10, No.16, 3402-3405, 2018. (Tokushima University Institutional Repository: 111892, DOI: 10.1002/cctc.201800714) |
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| 28. | Akira Shigenaga, Naoto Naruse and Akira Otaka : ProteoFind: A script for finding proteins that are suitable for chemical synthesis, Tetrahedron, Vol.74, No.19, 2291-2297, 2018. (Tokushima University Institutional Repository: 111928, DOI: 10.1016/j.tet.2018.03.030) |
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| 29. | Tsubasa Inokuma, Kohdai Nishida, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka : Direct enantioselective indolylation of peptidyl imine for the synthesis of indolyl glycine-containing peptides, Heterocycles, Vol.97, No.2, 1269-1287, 2018. (DOI: 10.3987/COM-18-S(T)86) |
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| 30. | Hiroshi Inaba, Akihito Uemura, Kazushi Morishita, Taiki Kohiki, Akira Shigenaga, Akira Otaka and Kazunori Matsuura : Light-induced propulsion of a giant liposome driven by peptide nanofibre growth, Scientific Reports, Vol.8, No.1, articlenumber-6243, 2018. (Tokushima University Institutional Repository: 112429, DOI: 10.1038/s41598-018-24675-7, PubMed: 29674666) |
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| 31. | Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Resin-bound crypto-thioester for native chemical ligation, Organic Letters, Vol.20, No.8, 2449-2453, 2018. (Tokushima University Institutional Repository: 111890, DOI: 10.1021/acs.orglett.8b00795) |
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| 32. | Chiharu Mizuguchi, Mitsuki Nakamura, Naoko Kurimitsu, Takashi Ohgita, Kazuchika Nishitsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Effect of phosphatidylserine and cholesterol on membrane-mediated fibril formation by the N-terminal amyloidogenic fragment of apolipoprotein A-I, Scientific Reports, Vol.8, No.1, Articlenumber-5497, 2018. (Tokushima University Institutional Repository: 112401, DOI: 10.1038/s41598-018-23920-3, PubMed: 29615818) |
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| 33. | Akira Otaka : Current Topics - Drug Discovery: Recent Progress and the Future Foreward, Chemical & Pharmaceutical Bulletin, Vol.66, No.3, 189-190, 2018. (DOI: 10.1248/cpb.c18-ctf6603) |
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| 34. | Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Naoto Naruse, Kohei Tsuji, Akira Shigenaga, Akira Otaka and Takahiko Hara : CXCL14 acts as a specific carrier of CpG into dendritic cells and activates Toll-like receptor 9-mediated adaptive immunity, EBioMedicine, Vol.24, 247-256, 2017. (Tokushima University Institutional Repository: 115089, DOI: 10.1016/j.ebiom.2017.09.012, PubMed: 28928016, Elsevier: Scopus) |
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| 35. | Taiki Kohiki, Yusuke Nishikawa, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Chemical synthetic platform for chlorpromazine oligomers that were reported as photo-degradation products of chlorpromazine, Chemical & Pharmaceutical Bulletin, Vol.65, No.12, 1161-1166, 2017. (Tokushima University Institutional Repository: 111929, DOI: 10.1248/cpb.c17-00692, PubMed: 29199220, Elsevier: Scopus) |
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| 36. | Keisuke Aihara, Tsubasa Inokuma, Takahisa Jichu, Zhenjian Lin, Feixue Fu, Kosuke Yamaoka, Akira Shigenaga, David A. Hutchins, Eric W. Schmidt and Akira Otaka : Cysteine-free intramolecular ligaiton of N-sulfanylethylanilide peptide using 4-mercaptobenzylphosphonic acid: Synthesis of cyclic peptide, trichamide, Synlett, Vol.28, No.15, 1944-1949, 2017. (Tokushima University Institutional Repository: 111889, DOI: 10.1055/s-0036-1589055) |
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| 37. | Tetsuro Yoshimaru, Keisuke Aihara, Masato Komatsu, Yosuke Matsushita, Yasumasa Okazaki, Shinya Toyokuni, Junko Honda, Mitsunori Sasa, Yasuo Miyoshi, Akira Otaka and Toyomasa Katagiri : Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics., Scientific Reports, Vol.7, No.1, 1821, 2017. (Tokushima University Institutional Repository: 112387, DOI: 10.1038/s41598-017-01951-6, PubMed: 28500289) |
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| 38. | Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka : Inside Front Cover: Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology, Organic & Biomolecular Chemistry, Vol.15, 5240, 2017. (DOI: 10.1039/C7OB90109G) |
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| 39. | Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka : Elucidation of inhibitor-binding pocket of D-amino acid oxidase using docking simulation and N-sulfanylethylanilide-based labeling technology, Organic & Biomolecular Chemistry, Vol.15, No.25, 5289-5297, 2017. (Tokushima University Institutional Repository: 111927, DOI: 10.1039/C7OB00633K) |
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| 40. | Akiko Yano, Yuko Takahashi, Hiromi Moriguchi, Tomoaki Inazumi, Tomoaki Koga, Akira Otaka, Yukihiko Sugimoto and Hironobu Hojo : An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gas, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1862, No.6, 615-622, 2017. (DOI: 10.1016/j.bbalip.2017.03.006, PubMed: 28336329) |
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| 41. | Tsubasa Inokuma, Takahisa Jichu, Kodai Nishida, Akira Shigenaga and Akira Otaka : A convenient method for preparation of -imino carboxylic acid derivatives and application to the asymmetric synthesis of unnatural -amino acid derivative, Chemical & Pharmaceutical Bulletin, Vol.65, No.6, 573-581, 2017. (DOI: 10.1248/cpb.c17-00158, PubMed: 28566650) |
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| 42. | Shugo Tsuda, Masayoshi Mochizuki, Ken Sakamoto, Masaya Denda, Hideki Nishio, Akira Otaka and Taku Yoshiya : N-Sulfanylethylaminooxybutyramide (SEAoxy): A Crypto-Thioester Compatible with Fmoc Solid-Phase Peptide Synthesis, Organic Letters, Vol.18, No.22, 5940-5943, 2016. (DOI: 10.1021/acs.orglett.6b03055, PubMed: 27805411) |
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| 43. | Shiho Mikawa, Chiharu Mizuguchi, Kazuchika Nishitsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Naomi Sakashita, Akira Otaka, Kenichi Akaji and Hiroyuki Saito : Heparin promotes fibril formation of the N-terminal fragment of amyloidogenic aplipoprotein A-I, FEBS Letters, Vol.590, 3492-3500, 2016. (DOI: 10.1002/1873-3468.12426, PubMed: 27654470, Elsevier: Scopus) |
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| 44. | Mitsuhiro Eto, Naoto Naruse, Kyohei Morimoto, Kosuke Yamaoka, Kohei Sato, Kohei Tsuji, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of an anilide-type scaffold for the thioester precursor N-sulfanylethylcoumarinyl amide, Organic Letters, Vol.18, No.17, 4416-4419, 2016. (Tokushima University Institutional Repository: 111879, DOI: 10.1021/acs.orglett.6b02207, PubMed: 27529363) |
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| 45. | Takahiro Nakamura, Kohei Sato, Naoto Naruse, Keisuke Kitakaze, Tsubasa Inokuma, Takatsugu Hirokawa, Akira Shigenaga, Kouji Itou and Akira Otaka : Back Cover: Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows access to protein library, ChemBioChem, Vol.17, No.20, 1994, 2016. (DOI: 10.1002/cbic.201600521) |
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| 46. | Takahiro Nakamura, Kohei Sato, Naoto Naruse, Keisuke Kitakaze, Tsubasa Inokuma, Takatsugu Hirokawa, Akira Shigenaga, Kouji Itou and Akira Otaka : Tailored synthesis of 162-residue S-monoglycosylated GM2-activator protein (GM2AP) analogues that allows access to protein library, ChemBioChem, Vol.17, No.20, 1986-1992, 2016. (Tokushima University Institutional Repository: 111880, DOI: 10.1002/cbic.201600400, PubMed: 27428709, Elsevier: Scopus) |
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| 47. | Masaya Denda, Takuya Morisaki, Taiki Kohiki, Jun Yamamoto, Kohei Sato, Ikuko Sagawa, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : Labelling of endogenous target protein via N-S acyl transfer-mediated activation of N-sulfanylethylanilide, Organic & Biomolecular Chemistry, Vol.14, 6244-6251, 2016. (Tokushima University Institutional Repository: 111885, DOI: 10.1039/C6OB01014H) |
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| 48. | Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Kouji Itou, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : An N-Sulfanylethylanilide-based traceable linker for enrichment and selective labelling of target proteins, Chemical Communications, Vol.52, 6911-6913, 2016. (Tokushima University Institutional Repository: 111925, DOI: 10.1039/C6CC01229A) |
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| 49. | Tatsuhiko Shimizu, Rin Miyajima, Naoto Naruse, Kosuke Yamaoka, Keisuke Aihara, Akira Shigenaga and Akira Otaka : Facile preparation of peptides with C-terminal N-alkylamide via radical-initiated dethiocarboxylation, Chemical & Pharmaceutical Bulletin, Vol.64, No.4, 375-378, 2016. (Tokushima University Institutional Repository: 111926, DOI: 10.1248/cpb.c15-01025, PubMed: 27039836, Elsevier: Scopus) |
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| 50. | Yuki Haraya, Ryo Nadai, Hitoshi Kimura, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Sakai-Kato, Kohsaku Kawakami, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita and Hiroyuki Saito : Enthalpy-driven interactions with sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides, Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1858, No.6, 1339-1349, 2016. (DOI: 10.1016/j.bbamem.2016.03.021, PubMed: 27003128, Elsevier: Scopus) |
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| 51. | Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka and Takayoshi Suzuki : Identification of SNAIL1 Peptide-Based Irreversible Lysine Specific Demethylase 1-Selective Inactivators, Journal of Medicinal Chemistry, Vol.59, No.4, 1531-1544, 2016. (DOI: 10.1021/acs.jmedchem.5b01323, PubMed: 26700437) |
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| 52. | Kitakaze Keisuke, Mizutani Yasumichi, Sugiyama Eiji, Tasaki Chikako, Daisuke Tsuji, Nobuo Maita, Hirokawa Takatsugu, Asanuma Daisuke, Kamiya Mako, Sato Kohei, Setou Mitsutoshi, Urano Yasuteru, Togawa Tadayasu, Akira Otaka, Sakuraba Hitoshi and Kouji Itou : Protease-resistant modified human β-hexosaminidase B ameliorates symptoms in GM2 gangliosidosis model, The Journal of Clinical Investigation, Vol.126, No.5, 1691-1703, 2016. (DOI: 10.1172/JCI85300, PubMed: 27018595) |
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| 53. | Tatsuhiko Shimizu, Rin Miyajima, Kohei Sato, Ken Sakamoto, Naoto Naruse, Miku Kita, Akira Shigenaga and Akira Otaka : Facile synthesis of C-terminal peptide thioacids under mild conditions from N-sulfanylethylanilide peptides, Tetrahedron, Vol.72, 992-998, 2016. (Tokushima University Institutional Repository: 111924, DOI: 10.1016/j.tet.2015.12.070) |
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| 54. | Hirokazu Kariyazono, Ryo Nadai, Rin Miyajima, Yuki Haraya, Teruhiko Baba, Akira Shigenaga, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide, Journal of Peptide Science, Vol.22, No.2, 116-122, 2016. (DOI: 10.1002/psc.2847, PubMed: 26780967, Elsevier: Scopus) |
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| 55. | Chiaki Komiya, Keisuke Aihara, Kou Morishita, Hao Ding, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of an intein-inspired amide cleavage chemical device, The Journal of Organic Chemistry, Vol.81, No.2, 699-707, 2016. (Tokushima University Institutional Repository: 111896, DOI: 10.1021/acs.joc.5b02399, PubMed: 26646813) |
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| 56. | Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : One-pot/sequential native chemical ligation using photo-caged crypto-thioester, Organic Letters, Vol.18, No.3, 596-599, 2016. (DOI: 10.1021/acs.orglett.5b03661, PubMed: 26753720) |
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| 57. | Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga, Miki Imanishi, Shiro Futaki and Akira Otaka : Preparation of peptide thioesters from naturally occurring sequences using reaction sequence consisting of regioselective S-cyanylation and hydrazinolysis, Biopolymers, Vol.106, No.4, 531-546, 2015. (Tokushima University Institutional Repository: 111898, DOI: 10.1002/bip.22757, PubMed: 26501985) |
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| 58. | Chiharu Mizuguchi, Fuka Ogata, Shiho Mikawa, Kohei Tsuji, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Amyloidogenic Mutation Promotes Fibril Formation of the N-terminal Apolipoprotein A-I on Lipid Membranes, The Journal of Biological Chemistry, Vol.290, No.34, 20947-20959, 2015. (DOI: 10.1074/jbc.M115.664227, PubMed: 26175149) |
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| 59. | Kohei Tsuji, Kosuke Tanegashima, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka : Efficient one-pot synthesis of CXCL14 and its derivative using an N-sulfanylethylanilide peptide as a peptide thioester equivalent and their biological evaluation, Bioorganic & Medicinal Chemistry, Vol.23, No.17, 5909-5914, 2015. (DOI: 10.1016/j.bmc.2015.06.064, PubMed: 26187016, Elsevier: Scopus) |
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| 60. | Koji Takagi, Hayato Fukuda, Satoshi Syuto, Akira Otaka and Mitsuhiro Arisawa : Safe removal of the allyl protecting groups of allyl esters using a recyclable, low-leaching and ligand-free palladium nanoparticle Catalyst, Advanced Synthesis & Catalysis, Vol.357, No.9, 2119-2124, 2015. (DOI: 10.1002/adsc.201500055, Elsevier: Scopus) |
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| 61. | Miku Kita, Jun Yamamoto, Takuya Morisaki, Chiaki Komiya, Tsubasa Inokuma, Licht Miyamoto, Koichiro Tsuchiya, Akira Shigenaga and Akira Otaka : Design and synthesis of a hydrogen peroxide-responsive amino acid that induces peptide bond cleavage after exposure to hydrogen peroxide, Tetrahedron Letters, Vol.56, No.28, 4228-4231, 2015. (Tokushima University Institutional Repository: 111909, DOI: 10.1016/j.tetlet.2015.05.060, Elsevier: Scopus) |
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| 62. | Deokho Jung, Kohei Sato, Kyougmi Min, Akira Shigenaga, Juyeon Jung, Akira Otaka and Youngeun Kwon : Photo-triggered fluorescent labelling of recombinant proteins in live cells, Chemical Communications, Vol.51, No.47, 9670-9673, 2015. (DOI: 10.1039/C5CC01067E, PubMed: 25977944, Elsevier: Scopus) |
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| 63. | Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Naoto Naruse, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka : The total chemical synthesis of the monoglycosylated GM2 ganglioside activator using a novel cysteine surrogate, Chemical Communications, Vol.51, No.49, 9946-9948, 2015. (Tokushima University Institutional Repository: 111882, DOI: 10.1039/C5CC02967H, PubMed: 26006093, Elsevier: Scopus) |
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| 64. | Keisuke Aihara, Tsubasa Inokuma, Chiaki Komiya, Akira Shigenaga and Akira Otaka : Synthesis of lactam-bridged cyclic peptides by using olefin metathesis and diimide reduction, Tetrahedron, Vol.71, No.24, 4183-4191, 2015. (Tokushima University Institutional Repository: 111884, DOI: 10.1016/j.tet.2015.04.093, Elsevier: Scopus) |
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| 65. | Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka : Development of chemical methodology for preparation of peptide thioesters applicable to naturally occurring peptides using a sequential quadruple acyl transfer system, ChemistryOpen, Vol.4, No.4, 448-452, 2015. (Tokushima University Institutional Repository: 111883, DOI: 10.1002/open.201500086, Elsevier: Scopus) |
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| 66. | Masahiro Furutani, Akihito Uemura, Akira Shigenaga, Chiaki Komiya, Akira Otaka and Kazunori Matsuura : Inside Back Cover: A photoinduced growth system of peptide nanofibres addressed by DNA hybridization, Chemical Communications, Vol.51, No.38, 8197, 2015. (DOI: 10.1039/C5CC90206A) |
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| 67. | Masahiro Furutani, Akihito Uemura, Akira Shigenaga, Chiaki Komiya, Akira Otaka and Kazunori Matsuura : A photoinduced growth system of peptide nanofibres addressed by DNA hybridization, Chemical Communications, Vol.51, No.38, 8020-8022, 2015. (DOI: 10.1039/c5cc01452b, PubMed: 25778790, Elsevier: Scopus) |
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| 68. | Yuki Haraya, Kento Tanaka, Kohei Tsuji, Yasuo Asami, Hironori Izawa, Akira Shigenaga, Akira Otaka, Hiroyuki Saito and Kohsaku Kawakami : Molecular Complex Composed of -Cyclodextrin-Grafted Chitosan and pH-Sensitive Amphipathic Peptide for Enhancing Cellular Cholesterol Efflux under Acidic pH, Bioconjugate Chemistry, Vol.26, No.3, 572-581, 2015. (DOI: 10.1021/acs.bioconjchem.5b00037, PubMed: 25705984, Elsevier: Scopus) |
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| 69. | Keisuke Aihara, Chiaki Komiya, Akira Shigenaga, Tsubasa Inokuma, Daisuke Takahashi and Akira Otaka : Liquid-phase synthesis of bridged peptides using olefin metathesis of protected peptide with long aliphatic chain anchor, Organic Letters, Vol.17, No.3, 696-699, 2015. (Tokushima University Institutional Repository: 111891, DOI: 10.1021/ol503718j, PubMed: 25629979, Elsevier: Scopus) |
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| 70. | Jun Yamamoto, Nami Maeda, Chiaki Komiya, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : Development of a fluoride-responsive amide bond cleavage device that is potentially applicable to a traceable linker, Tetrahedron, Vol.70, No.34, 5122-5127, 2014. (Tokushima University Institutional Repository: 111908, DOI: 10.1016/j.tet.2014.05.110, Elsevier: Scopus) |
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| 71. | Jun Yamamoto, Masaya Denda, Nami Maeda, Miku Kita, Chiaki Komiya, Tomohiro Tanaka, Wataru Nomura, Hirokazu Tamamura, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : Development of a traceable linker containing a thiol-responsive amino acid for the enrichment and selective labelling of target proteins, Organic & Biomolecular Chemistry, Vol.12, No.23, 3821-3826, 2014. (Tokushima University Institutional Repository: 111911, DOI: 10.1039/C4OB00622D, PubMed: 24806338, Elsevier: Scopus) |
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| 72. | Koji Ebisuno, Masaya Denda, Keiji Ogura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein, Bioorganic & Medicinal Chemistry, Vol.22, No.11, 2984-2991, 2014. (Tokushima University Institutional Repository: 111910, DOI: 10.1016/j.bmc.2014.04.002, PubMed: 24768166, Elsevier: Scopus) |
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| 73. | Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto and Akira Otaka : Examination of native chemical ligation using peptidyl prolyl thioester, Chemical Communications, Vol.50, No.1, 58-60, 2014. (DOI: 10.1039/C3CC47228K, PubMed: 24195110, Elsevier: Scopus) |
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| 74. | Emi Adachi, Asako Kosaka, Kohei Tsuji, Chiharu Mizuguchi, Hiroyuki Kawashima, Akira Shigenaga, Kohjiro Nagao, Kenichi Akaji, Akira Otaka and Hiroyuki Saito : The extreme N-terminal region of human apolipoprotein A-I has a strong propensity to form amyloid fibrils., FEBS Letters, Vol.588, No.3, 389-394, 2013. (DOI: 10.1016/j.febslet.2013.11.031, PubMed: 24316228) |
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| 75. | Kosuke Tanegashima, Kohei Tsuji, Kenji Suzuki, Akira Shigenaga, Akira Otaka and Takahiko Hara : Dimeric peptides of the C-terminal region of CXCL14 function as CXCL12 inhibitors, FEBS Letters, Vol.587, No.23, 3770-3775, 2013. (DOI: 10.1016/j.febslet.2013.10.017, PubMed: 24161674, Elsevier: Scopus) |
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| 76. | Kohei Sato, Akira Shigenaga, Keisuke Kitakaze, Ken Sakamoto, Daisuke Tsuji, Kouji Itou and Akira Otaka : Chemical synthesis of biologically active monoglycosylated GM2-activator protein analog using N-sulfanylethylanilide peptide, Angewandte Chemie International Edition, Vol.52, No.30, 7855-7859, 2013. (DOI: 10.1002/anie.201303390, PubMed: 23765733, Elsevier: Scopus) |
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| 77. | Kosuke Tanegashima, Kenji Suzuki, Yuki Nakayama, Kohei Tsuji, Akira Shigenaga, Akira Otaka and Takahiko Hara : CXCL14 is a natural inhibitor of the CXCL12-CXCR4 signaling axis, FEBS Letters, Vol.587, No.12, 1731-1735, 2013. (DOI: 10.1016/j.febslet.2013.04.046, PubMed: 23669361) |
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| 78. | Ken Sakamoto, Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Hajime Hibino, Yuji Nishiuchi and Akira Otaka : Synthetic procedure for N-Fmoc amino acyl-N-sulfanylethylaniline linker as crypto-peptide thioester precursor with application to native chemical ligation, The Journal of Organic Chemistry, Vol.77, No.16, 6948-6958, 2012. (DOI: 10.1021/jo3011107, PubMed: 22816612) |
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| 79. | Keiji Ogura, Akira Shigenaga, Koji Ebisuno, Hiroko Hirakawa and Akira Otaka : Fmoc-based solid phase synthesis of adenylylated peptides using diester-type adenylylated amino acid derivatives, Tetrahedron Letters, Vol.53, No.27, 3429-3432, 2012. (DOI: 10.1016/j.tetlet.2012.04.063) |
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| 80. | Akira Shigenaga, Keiji Ogura, Hiroko Hirakawa, Jun Yamamoto, Koji Ebisuno, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka : Development of a reduction-responsive amino acid that induces peptide bond cleavage in hypoxic cells, ChemBioChem, Vol.13, 968-971, 2012. (Tokushima University Institutional Repository: 111913, DOI: 10.1002/cbic.201200141, PubMed: 22505188) |
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| 81. | Hao Ding, Akira Shigenaga, Kohei Sato, Ko Morishita and Akira Otaka : Dual kinetically-controlled native chemical ligation using a combination of sulfanylproline and sulfanylethylanilide peptide, Organic Letters, Vol.13, No.20, 5588-5591, 2011. (DOI: 10.1021/ol202316v, PubMed: 21916452) |
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| 82. | Akira Shigenaga, Ko Morishita, Keiko Yamaguchi, Hao Ding, Koji Ebisuno, Kohei Sato, Jun Yamamoto, Kenichi Akaji and Akira Otaka : Development of UV-responsive catch-and-release system of a cysteine protease model peptide, Tetrahedron, Vol.67, No.46, 8879-8886, 2011. (Tokushima University Institutional Repository: 111905, DOI: 10.1016/j.tet.2011.09.062) |
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| 83. | Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Yoshitake Sumikawa, Ken Sakamoto and Akira Otaka : N-Sulfanylethylanilide Peptide as a Crypto-Thioester Peptide, ChemBioChem, Vol.12, No.12, 1840-1844, 2011. (DOI: 10.1002/cbic.201100241, PubMed: 21739560) |
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| 84. | Kohei Tsuji, Akira Shigenaga, Yoshitake Sumikawa, Kosuke Tanegashima, Kohei Sato, Keisuke Aihara, Takahiko Hara and Akira Otaka : Application of N-C- or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation, Bioorganic & Medicinal Chemistry, Vol.19, No.13, 4014-4020, 2011. (DOI: 10.1016/j.bmc.2011.05.018, PubMed: 21658958) |
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| 85. | Akira Shigenaga, Hiroko Hirakawa, Jun Yamamoto, Keiji Ogura, Masaya Denda, Keiko Yamaguchi, Daisuke Tsuji, Kouji Itou and Akira Otaka : Design and synthesis of caged ceramide: UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O-N acyl transfer, Tetrahedron, Vol.67, No.22, 3984-3990, 2011. (Tokushima University Institutional Repository: 111907, DOI: 10.1016/j.tet.2011.04.048) |
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| 86. | Akira Shigenaga, Jun Yamamoto, Naomi Nishioka and Akira Otaka : Enantioselective synthesis of stimulus-responsive amino acid via asymmetric -amination of aldehyde, Tetrahedron, Vol.66, No.37, 7367-7372, 2010. (Tokushima University Institutional Repository: 111904, DOI: 10.1016/j.tet.2010.07.033) |
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| 87. | Yoshimi Nishikawa, Yoshifumi Takahara, Shinichi Asada, Akira Shigenaga, Akira Otaka, Kouki Kitagawa and Takaki Koide : A structure activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP47, Bioorganic & Medicinal Chemistry, Vol.18, No.11, 3767-3775, 2010. (DOI: 10.1016/j.bmc.2010.04.054, PubMed: 20471275) |
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| 88. | Akira Shigenaga, Jun Yamamoto, Yoshitake Sumikawa, Toshiaki Furuta and Akira Otaka : Development and photo-responsive peptide bond cleavage reaction of two-photon near-infrared excitation responsive peptide, Tetrahedron Letters, Vol.51, No.21, 2868-2871, 2010. (Tokushima University Institutional Repository: 111903, DOI: 10.1016/j.tetlet.2010.03.079) |
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| 89. | Akira Shigenaga, Yoshitake Sumikawa, Shugo Tsuda, Kohei Sato and Akira Otaka : Sequential native chemical ligation utilizing peptide thioacids derived from newly developed Fmoc-based synthetic method, Tetrahedron, Vol.66, No.18, 3290-3296, 2010. (DOI: 10.1016/j.tet.2010.03.016) |
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| 90. | Akira Shigenaga, Jun Yamamoto, Hiroko Hirakawa, Keiji Ogura, Ko Morishita, Nami Maeda and Akira Otaka : Development of thiol-responsive amide bond cleavage device and its application for peptide nucleic acid-based DNA releasing system, Tetrahedron Letters, Vol.51, No.18, 2525-2528, 2010. (Tokushima University Institutional Repository: 111901, DOI: 10.1016/j.tetlet.2010.03.006) |
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| 91. | Yoshito Fujimoto, Takuma Shiraki, Yuji Horiuchi, Tsuyoshi Waku, Akira Shigenaga, Akira Otaka, Tsuyoshi Ikura, Kazuhiko Igarashi, Saburo Aimoto, Shin-ichi Take and Kosuke Morikawa : Proline cis/trans isomerase Pin1 regulates peroxisome proliferators-activated receptor g activity through the direct binding to the AF-1 domain, The Journal of Biological Chemistry, Vol.285, No.5, 3126-3132, 2010. (DOI: 10.1074/jbc.M109.055095, PubMed: 19996102) |
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| 92. | S.-M Yun, T Moulaei, D Lim, J.K Bang, J.-E Park, S.R Shenoy, F Liu, Y.H Kang, C Liao, N.-K Soung, S Lee, D.-Y Yoon, Y Lim, D.-H Lee, Akira Otaka, E Appella, J.B McMahon, M.C Nicklaus, T.R.Jr. Burke, M.B Yaffe, A Wlodawer and K.S Lee : Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1, Nature Structural & Molecular Biology, Vol.16, No.8, 876-882, 2009. (DOI: 10.1038/nsmb.1628, PubMed: 19597481) |
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| 93. | Yoko Yamaki, Akira Shigenaga, Jinglan Li, Yasuyuki Shimohigashi and Akira Otaka : Synthesis of amide-type fluoroalkene dipeptide isosteres by an intramolecular redox reaction, The Journal of Organic Chemistry, Vol.74, No.9, 3278-3285, 2009. (DOI: 10.1021/jo900135t, PubMed: 19331368) |
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| 94. | Yoko Yamaki, Akira Shigenaga, Kenji Tomita, Tetsuo Narumi, Nobutaka Fujii and Akira Otaka : Synthesis of fluoroalkene dipeptide isosteres by an intramolecular redox reaction utilizing N-heterocyclic carbenes (NHCs), The Journal of Organic Chemistry, Vol.74, No.9, 3272-3277, 2009. (DOI: 10.1021/jo900134k, PubMed: 19331367) |
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| 95. | Shugo Tsuda, Akira Shigenaga, Kiyomi Bando and Akira Otaka : N→S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives, Organic Letters, Vol.11, No.4, 823-826, 2009. (DOI: 10.1021/ol8028093, PubMed: 19161341) |
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| 96. | Akira Shigenaga, Jun Yamamoto, Hiroko Hirakawa, Keiko Yamaguchi and Akira Otaka : FRET-based assay of the processing reaction kinetics of stimulus-responsive peptides: Influence of amino acid sequence on reaction kinetics, Tetrahedron, Vol.65, No.11, 2212-2216, 2009. (Tokushima University Institutional Repository: 111902, DOI: 10.1016/j.tet.2009.01.063) |
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| 97. | H Nishikawa, S Nakamura, E Kodama, S Ito, K Kajiwara, K Izumi, Y Sakagami, S Oishi, T Ohkubo, Y Kobayashi, Akira Otaka, N Fujii and M Matsuoka : Electrostatically constrained alpha-helical peptide inhibits replication of HIV-1 resistant to Enfuvirtide, The International Journal of Biochemistry & Cell Biology, Vol.41, No.4, 891-899, 2009. (DOI: 10.1016/j.biocel.2008.08.039, PubMed: 18834950) |
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| 98. | H. Nishikawa, S. Oishi, M. Fujita, K. Watanabe, R. Tokiwa, H. Ohno, E. Kodama, K. Izumi, K. Kajiwara, T. Naitoh, M. Matsuoka, Akira Otaka and N. Fujii : Identification of minimal sequence for HIV-1 fusion inhibitors, Bioorganic & Medicinal Chemistry, Vol.16, No.20, 9184-9187, 2008. (DOI: 10.1016/j.bmc.2008.09.018, PubMed: 18819810) |
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| 99. | Ujike Makoto, Nishikawa Hiroki, Akira Otaka, Yamamoto Naoki, Yamamoto Norio, Matsuoka Masao, Kodama Eiichi, Fujii Nobutaka and Taguchi Fumihiro : Heptad Repeat-Derived Peptides Block Protease-Mediated Direct Entry from the Cell Surface of Severe Acute Respiratory Syndrome Coronavirus but Not Entry via the Endosomal Pathway, Journal of Virology, Vol.82, No.1, 588-592, 2008. (DOI: 10.1128/JVI.01697-07, PubMed: 17942557) |
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| 100. | Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka : Synthesis of a stimulus-responsive processing device and its application to a nucleocytoplasmic shuttle peptide, ChemBioChem, Vol.8, No.16, 1929-1931, 2007. (Tokushima University Institutional Repository: 111899, DOI: 10.1002/cbic.200700442, PubMed: 17899557) |
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| 101. | Yoshikazu Sasaki, Keiko Yamaguchi, Takashi Tsuji, Akira Shigenaga, Nobutaka Fujii and Akira Otaka : Development of copper-mediated allylation of c-activated-a,b-unsaturated lactam toward peptide mimetic synthesis, Tetrahedron Letters, Vol.48, No.18, 3221-3224, 2007. (DOI: 10.1016/j.tetlet.2007.03.017) |
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| 102. | Y. Sasaki, Akira Shigenaga, N. Fujii and Akira Otaka : Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium(II) diiodide (SmI2)-mediated reductive alkylation reaction., Tetrahedron, Vol.63, No.9, 2000-2008, 2007. (DOI: 10.1016/j.tet.2006.12.055) |
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| 103. | Tesuo Narumi, Ayumu Niida, Kenji Tomita, Shinya Oishi, Akira Otaka, Hiroaki Ohono and Nobutaka Fujii : A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres., Chemical Communications, No.45, 4720-4722, 2006. (DOI: 10.1039/b608596b, PubMed: 17109048) |
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| 104. | Yoshikazu Sasaki, Ayumu Niida, Takashi Tsuji, Akira Shigenaga, Nobutaka Fujii and Akira Otaka : Stereoselective Synthesis of (Z)-alkene-containing proline dipeptide mimetics, The Journal of Organic Chemistry, Vol.71, No.13, 4969-4979, 2006. (DOI: 10.1021/jo0606002, PubMed: 16776529) |
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| 105. | Ayumu Niida, Makiko Mizumoto, Tetsuo Narumi, Eriko Inokuchi, Shinya Oishi, Hiroaki Ohono, Akira Otaka, Kazuo Kitaura and Fujii Nobutaka : Synthesis of (Z)-Alkene and (E)-Fluoroalkene-Containing Diketopiperazine Mimetics Utilizing Oraganocopper-Mediated Reduction-Alkylation and Diastereoselectivity Examination Using DFT Calculations., The Journal of Organic Chemistry, Vol.71, No.11, 4118-4129, 2006. (DOI: 10.1021/jo060202z, PubMed: 16709051) |
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| 106. | Ayumu Niida, Hiroaki Tanigaki, Eriko Inokuchi, Yoshikazu Sasaki, Shinya Oishi, Hiroaki Ohno, Hirokazu Tamamura, Zixuan Wang, C Stephene Peiper, Kazuo Kitaura, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of 3,6-Disubstituted-3,6-dihydropyridin-2-ones as Potential Diketopiperazine Mimetics Using Organocopper-Mediated anti-SN2' Reactions and Their Use in the Preparation of Low-Molecule CXCR4 Antagonists., The Journal of Organic Chemistry, Vol.71, No.10, 3942-3951, 2006. (DOI: 10.1021/jo060390t, PubMed: 16674071, Elsevier: Scopus) |
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| 107. | T. Koide, Y. Nishikawa, S. Asada, C. M. Yamazaki, Y. Takahara, D. L. Homma, Akira Otaka, K. Ohtani, N. Wakamiya, K. Nagata and K. Kitagawa : Specific recognition of the collagen triple helix by chaperone HSP47. II. The HSP47-binding structural motif in collagens and related proteins, The Journal of Biological Chemistry, Vol.281, No.16, 11177-11185, 2006. (DOI: 10.1074/jbc.M601369200, PubMed: 16484215) |
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| 108. | M Nakano, T Hamada, T Hayashi, S Yonemitsu, L Miyamoto, T Toyoda, S Tanaka, H Masuzaki, K Ebihara, Y Ogawa, K Hosoda, G Inoue, Y Yoshimasa, Akira Otaka, T Fushiki and K Nakao : a2 Isoform-specific activation of 5 adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle, Metabolism: Clinical and Experimental, Vol.55, No.3, 300-308, 2006. (DOI: 10.1016/j.metabol.2005.09.003, PubMed: 16483872) |
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| 109. | Ayumu Niida, Kenji Tomita, Makiko Mizumoto, Hiroaki Tanigaki, Tomohiro Terada, Shinya Oishi, Akira Otaka, Ken-ichi Inui and Nobutaka Fujii : Unequivocal Synthesis of (Z)-Alkene and (E)-Fluoroalkene Dipeptide Isosters to Probe Structural Requirements of Peptide Transporter PEPT1., Organic Letters, Vol.8, No.4, 613-616, 2006. (DOI: 10.1021/ol052781k, PubMed: 16468724) |
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| 110. | Shinya Ohishi, Kazuhide Miyamoto, Ayumu Niida, Mikiko Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka, Yoshihiro Kuroda, Akira Asai and Fujii Nobutaka : Application of Tri- and Tetrasubstituted Alkene Dipeptide Mimetics to Conformational Studies of Cyclic RGD Peptides., Tetrahedron, Vol.62, No.7, 1416-1424, 2006. (DOI: 10.1016/j.tet.2005.11.033, Elsevier: Scopus) |
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| 111. | Yusuke Ohta, Saori Itoh, Akira Shigenaga, Saori Shintaku, Nobutaka Fujii and Akira Otaka : Cysteine-Derived S-Protected Oxazolidinones: Potential Chemical Devices for the Preparation of Peptide Thioesters, Organic Letters, Vol.8, No.3, 467-470, 2006. (DOI: 10.1021/ol052755m, PubMed: 16435861, Elsevier: Scopus) |
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| 112. | Ayumu Niida, Zixuan Wang, Kenji Tomita, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Jean-Marc Navenot, James R. Broach, Stephen C. Peiper and Nobutaka Fujii : Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity, Bioorganic & Medicinal Chemistry Letters, Vol.16, No.1, 134-137, 2006. (DOI: 10.1016/j.bmcl.2005.09.054, PubMed: 16242330, Elsevier: Scopus) |
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| 113. | Hirokazu Tamamura, Ai Esaka, Teppei Ogawa, Takanobu Araki, Satoshi Ueda, Zixuan Wang, John O. Trent, Hiroshi Tsutsumi, Hiroyuki Masuno, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka and Nobutaka Fuji : Structure activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds, Organic & Biomolecular Chemistry, Vol.3, No.24, 4392-4394, 2005. (DOI: 10.1039/b513145f, PubMed: 16327900) |
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| 114. | Satoshi Ueda, Mizuno Fujita, Hirokazu Tamamura, Nobutaka Fujii and Akira Otaka : Photolabile Protection for One-Pot Sequential Native Chemical Ligation, ChemBioChem, Vol.6, No.11, 1983-1986, 2005. (DOI: 10.1002/cbic.200500272, PubMed: 16206319) |
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| 115. | Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Development of Anti-HIV Agents Targeting Dynamic Supramolecular Mechanism: Entry and Fusion Inhibitors Based on CXCR4/CCR5 Antagonists and gp41-C34-Remodeling Peptides, Current HIV Research, Vol.3, No.4, 289-301, 2005. (DOI: 10.2174/157016205774370429, PubMed: 16250877) |
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| 116. | Ayumu Niida, Shinya Oishi, Yoshikazu Sasaki, Makiko Mizumoto, Hirokazu Tamamura, Nobutaka Fujii and Akira Otaka : Facile access to (Z)-alkene-containing diketopiperazine mimetics utilizing organocopper-mediated anti-SN2 reactions, Tetrahedron Letters, Vol.46, No.24, 4183-4186, 2005. (DOI: 10.1016/j.tetlet.2005.04.057) |
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| 117. | Hirokazu Tamamura, Takanobu Araki, Satoshi Ueda, Zixuan Wang, Shinya Oishi, Ai Esaka, John O. Trent, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Akira Otaka and Nobutaka Fujii : Identification of Novel Low Molecular Weight CXCR4 Antagonists by Structural Tuning of Cyclic Tetrapeptide Scaffolds, Journal of Medicinal Chemistry, Vol.48, No.9, 3280-3289, 2005. (DOI: 10.1021/jm050009h, PubMed: 15857134) |
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| 118. | Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Zixuan Wang, Shuichi Kusano, Shigemi Terakubo, John O. Trent, Stephen C. Peiper, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-Type (E)-Alkene Dipeptide Isosteres and Its Application to the Synthesis and Biological Evaluation of Pseudopeptide Analogues of the CXCR4 Antagonist FC131, Journal of Medicinal Chemistry, Vol.48, No.2, 380-391, 2005. (DOI: 10.1021/jm049429h, PubMed: 15658852) |
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| 119. | Daisuke Nameki, Eiichi Kodama, Mieko Ikeuchi, Naoto Mabuchi, Akira Otaka, Hirokazu Tamamura, Mutsuhito Ohno, Nobutaka Fujii and Masao Matsuoka : Mutations Conferring Resistance to Human Immunodeficiency Virus Type 1 Fusion Inhibitors Are Restricted by gp41 and Rev-Responsive Element Functions, Journal of Virology, Vol.79, No.2, 764-770, 2005. (DOI: 10.1128/JVI.79.2.764-770.2005, PubMed: 15613304) |
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| 120. | Hirokazu Tamamura, Miho Fujisawa, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent, FEBS Letters, Vol.569, No.1-3, 99-104, 2004. (DOI: 10.1016/j.febslet.2004.05.056, PubMed: 15225616) |
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| 121. | Taro Toyoda, Tatsuya Hayashi, Licht Miyamoto, Shin Yonemitsu, Masako Nakano, Satsuki Tanaka, Ken Ebihara, Hiroaki Masuzaki, Kiminori Hosoda, Gen Inoue, Akira Otaka, Kenji Sato, Tohru Fushiki and Kazuwa Nakao : Possible involvement of the α1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle, American Journal of Physiology, Endocrinology and Metabolism, Vol.287, No.1, E166-173, 2004. (DOI: 10.1152/ajpendo.00487.2003, PubMed: 15026306) |
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| 122. | Akira Otaka, Satoshi Ueda, Kenji Tomita, Yoshiaki Yano, Hirokazu Tamamura, Katsumi Matsuzaki and Nobutaka Fujii : Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation, Chemical Communications, No.15, 1722-1723, 2004. (DOI: 10.1039/B404008B, PubMed: 15278155) |
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| 123. | Norio Yamamoto, Rongge Yang, Yoshiyuki Yoshinaka, Shinji Amari, Tatsuya Nakano, Jindrich Cinatl, Holger Rabenau, Hans Wilhelm Doerr, Gerhard Hunsmann, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii and Naoki Yamamoto : HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus, Biochemical and Biophysical Research Communications, Vol.318, No.3, 719-725, 2004. (DOI: 10.1016/j.bbrc.2004.04.083, PubMed: 15144898) |
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| 124. | Hirokazu Tamamura, Makiko Mizumoto, Kenichi Hiramatsu, Shuichi Kusano, Shigemi Terakubo, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides, Organic & Biomolecular Chemistry, Vol.2, No.8, 1255-1257, 2004. (DOI: 10.1039/b401485p, PubMed: 15064805) |
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| 125. | Akira Otaka, Junko Watanabe, Akira Yukimasa, Yoshikazu Sasaki, Hideaki Watanabe, Takayoshi Kinoshita, Shinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : SmI2-Mediated Reduction of γ,γ-Difluoro-α,β-enoates with Application to the Synthesis of Functionalized (Z)-Fluoroalkene-Type Dipeptide Isosteres, The Journal of Organic Chemistry, Vol.69, No.5, 1634-1645, 2004. (DOI: 10.1021/jo035709d, PubMed: 14987023) |
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| 126. | Hirokazu Tamamura, Kenichi Hiramatsu, Makiko Mizumoto, Satoshi Ueda, Shuichi Kusano, Shigemi Terakubo, Miki Akamatsu, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists, Organic & Biomolecular Chemistry, Vol.1, No.21, 3663-3669, 2003. (DOI: 10.1039/b306613b, PubMed: 14649897) |
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| 127. | Hirokazu Tamamura, Kenichi Hiramatsu, Shuichi Kusano, Shigemi Terakubo, Naoki Yamamoto, John O. Trent, Zixuan Wang, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives, Organic & Biomolecular Chemistry, Vol.1, No.21, 3656-3662, 2003. (DOI: 10.1039/b306473p, PubMed: 14649896) |
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| 128. | Hirokazu Tamamura, Akira Hori, Naoyuki Kanzaki, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Fujii Nobutaka : T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer, FEBS Letters, Vol.550, No.3, 79-83, 2003. (DOI: 10.1016/S0014-5793(03)00824-X, PubMed: 12935890) |
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| 129. | Akira Otaka, Akira Yukimasa, Junko Watanabe, Yoshikazu Sasaki, Sinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : Application of samarium diiodide (SmI2)-induced reduction of γ-acetoxy-α,β-enoates with α-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives, Chemical Communications, No.15, 1834-1835, 2003. (DOI: 10.1039/b303718e, PubMed: 12931990, Elsevier: Scopus) |
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| 130. | Nobutaka Fujii, Shinya Oishi, Kenichi Hiramatsu, Takanobu Araki, Satoshi Ueda, Hirokazu Tamamura, Akira Otaka, Shuichi Kusano, Shigemi Terakubo, Hideki Nakashima, James A. Broach, John O. Trent, Zi-xuan Wang and Stephen C. Peiper : Molecular-Size Reduction of a Potent CXCR4-Chemokine Antagonist Using Orthogonal Combination of Conformation- and Sequence-Based Libraries, Angewandte Chemie International Edition, Vol.42, No.28, 3251-3253, 2003. (DOI: 10.1002/anie.200351024, PubMed: 12876735) |
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| 131. | Hirokazu Tamamura, Terukazu Kato, Akira Otaka and Nobutaka Fujii : Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies, Organic & Biomolecular Chemistry, Vol.1, No.14, 2468-2473, 2003. (DOI: 10.1039/b304842j, PubMed: 12956063) |
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| 132. | Hirokazu Tamamura, Yasuhiro Koh, Satoshi Ueda, Yoshikazu Sasaki, Tomonori Yamasaki, Manabu Aoki, Kenji Maeda, Yoriko Watai, Hisashi Arikuni, Akira Otaka, Hiroaki Mitsuya and Nobutaka Fujii : Reduction of Peptide Character of HIV Protease Inhibitors That Exhibit Nanomolar Potency against Multidrug Resistant HIV-1 Strains, Journal of Medicinal Chemistry, Vol.46, No.9, 1764-1768, 2003. (DOI: 10.1021/jm020537i, PubMed: 12699395) |
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| 133. | Shinya Oishi, Takae Kamano, Ayumu Niida, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Diastereoselective Synthesis of New Ψ [(E)-CH=CMe]- and Ψ [(Z)-CH=CMe]-type Alkene Dipeptide Isosteres by Organocopper Reagents and Application to Conformationally Restricted Cyclic RGD Peptidomimetics, The Journal of Organic Chemistry, Vol.67, No.17, 6162-6173, 2002. (DOI: 10.1021/jo025923m, PubMed: 12182657) |
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| 134. | Akira Otaka, Fumihiko Katagiri, Takayoshi Kinoshita, Yoshihiko Odagaki, Shinya Oishi, Hirokazu Tamamura, Nobuyuki Hamanaka and Nobutaka Fujii : Regio- and Stereoselective Synthesis of (E)-Alkene trans-Xaa-Pro Dipeptide Mimetics Utilizing Organocopper-Mediated Anti-SN2' Reactions, The Journal of Organic Chemistry, Vol.67, No.17, 6152-6161, 2002. (DOI: 10.1021/jo025922u, PubMed: 12182656) |
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| 135. | Akira Otaka, Miki Nakamura, Daisuke Nameki, Eiichi Kodama, Susumu Uchiyama, Syota Nakamura, Hiroaki Nakano, Hirokazu Tamamura, Yuji Kobayashi, Masao Matsuoka and Nobutaka Fujii : Remodeling of gp41-C34 Peptide Leads to Highly Effective Inhibitors of the Fusion of HIV-1 with Target Cells, Angewandte Chemie International Edition, Vol.41, No.16, 2937-2940, 2002. (DOI: 10.1002/1521-3773(20020816)41:16<2937::AID-ANIE2937>3.0.CO;2-J, PubMed: 12203417) |
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| 136. | Masayoshi Makino, Ikuko Okazaki, Shingo Kasai, Norio Nishi, Maria Bougaeva, Benjamin S. Weeks, Akira Otaka, Peter K. Nielsen, Yoshihiko Yamada and Motoyoshi Nomizu : Identification of Cell Binding Sites in the Laminin α5-Chain G Domain, Experimental Cell Research, Vol.277, No.1, 95-106, 2002. (DOI: 10.1006/excr.2002.5540, PubMed: 12061820, Elsevier: Scopus) |
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| 137. | Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Shinya Oishi, Hiromu Habashita, Taisei Kanamoto, Kazuyo Gotoh, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Certification of the Critical Importance of L-3-(2-Naphthyl)alanine at Position 3 of a Specific CXCR4 Inhibitor, T140, Leads to an Exploratory Performance of Its Downsizing Study, Bioorganic & Medicinal Chemistry, Vol.10, No.5, 1417-1426, 2002. (DOI: 10.1016/S0968-0896(01)00419-9, PubMed: 11886804) |
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| 138. | Shinya Oishi, Takae Kamano, Ayumu Niida, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka and Nobutaka Fujii : Diastereoselective synthesis of psi[(E)-CH=CMe]- and psi[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-S(N)2' reaction, Organic Letters, Vol.4, No.7, 1051-1054, 2002. (DOI: 10.1021/ol016834j, PubMed: 11922780) |
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| 139. | Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihiko Odagaki, Hirokazu Tamamura, Akira Otaka, Nobuyuki Hamanaka and Nobutaka Fujii : Diastereoselective synthesis of psi[(E)-CMe=CH]- and psi[(E)-CMe=CMe]- type dipeptide isosteres based on organocopper-mediated anti-S(N)2' reaction, Organic Letters, Vol.4, No.7, 1055-1058, 2002. (DOI: 10.1021/ol016835b, PubMed: 11922781) |
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| 140. | Ryo Hosotani, Yoshiharu Miyamoto, Koji Fujimoto, Ryuichiro Doi, Akira Otaka, Nobutaka Fujii and Masayuki Imamura : Trojan p16 Peptide Suppresses Pancreatic Cancer Growth and Prolongs Survival in Mice, Clinical Cancer Research, Vol.8, No.4, 1271-1276, 2002. (PubMed: 11948142) |
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| 141. | Hirokazu Tamamura, Kenichi Hiramatsu, Kazuhide Miyamoto, Akane Omagari, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Yoshihiro Kuroda, Terumichi Nakagawa, Akira Otaka and Nobutaka Fujii : Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: The insertion of an (E)-alkene dipeptide isostere into the βII' -turn moiety, Bioorganic & Medicinal Chemistry Letters, Vol.12, No.6, 923-928, 2002. (DOI: 10.1016/S0960-894X(02)00041-0, PubMed: 11958995, Elsevier: Scopus) |
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| 142. | Yoshihito Taniguchi, Helena Karlström, Johan Lundkvist, Tomohiko Mizutani, Akira Otaka, Monica Vestling, Alan Bernstein, Dorit Donoviel, Urban Lendahl and Tasuku Honjo : Notch receptor cleavage depends on but is not directly executed by presenilins, Proceedings of the National Academy of Sciences of the United States of America, Vol.99, No.6, 4014-4019, 2002. (DOI: 10.1073/pnas.052017699) |
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| 143. | Shinya Oishi, Ayumu Niida, Takae Kamano, Yoshihisa Miwa, Tooru Taga, Yoshihiko Odagaki, Nobuyuki Hamanaka, Mikio Yamamoto, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Regio- and stereoselective ring-opening of chiral 1,3-oxazolidin-2-one derivatives by organocopper reagents provides novel access to di-, tri- and tetra-substituted alkene dipeptide isosteres, Journal of the Chemical Society, Perkin Transactions 1, 1786-1793, 2002. (DOI: 10.1039/b203482d, Elsevier: Scopus) |
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| 144. | Hirokazu Tamamura, Tadakazu Hori, Akira Otaka and Nobutaka Fujii : Efficient stereoselective synthesis of peptidomimetics containing hydroxyethylamine dipeptide isosteres utilizing the aza-Payne rearrangement and O, N-acyl transfer reactions, Journal of the Chemical Society, Perkin Transactions 1, Vol.5, 577-580, 2002. (DOI: 10.1039/B200324B, Elsevier: Scopus) |
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| 145. | Toshiaki Hara, Yasuyuki Mitani, Kyoko Tanaka, Natsuko Uematsu, Asako Takakura, Tomoya Tachi, Hiroaki Kodama, Michio Kondo, Harumi Mori, Akira Otaka, Nobutaka Fujii and Katsumi Matsuzaki : Heterodimer Formation between the Antimicrobial Peptides Magainin 2 and PGLa in Lipid Bilayers: A Cross-Linking Study, Biochemistry, Vol.40, No.41, 12395-12399, 2001. (DOI: 10.1021/bi011413v, PubMed: 11591159) |
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| 146. | Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Shinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : New access to α-substituted (Z)-fluoroalkene dipeptide isosteres utilizing organocopper reagents under `reduction oxidative alkylation (R-OA)' conditions, Tetrahedron Letters, Vol.42, No.32, 5443-5446, 2001. (DOI: 10.1016/S0040-4039(01)01010-3, Elsevier: Scopus) |
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| 147. | Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Taisei Kanamoto, Kazuyo Gotoh, Kenji Kanbara, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation, Bioorganic & Medicinal Chemistry, Vol.9, No.8, 2179-2187, 2001. (DOI: 10.1016/S0968-0896(01)00128-6, PubMed: 11504655, Elsevier: Scopus) |
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| 148. | Hirokazu Tamamura, Akane Omagari, Kenichi Hiramatsu, Kazuyo Gotoh, Taisei Kanamoto, Younong Xu, Eiichi Kodama, Masao Matsuoka, Toshio Hattori, Naoki Yamamoto, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140, Bioorganic & Medicinal Chemistry Letters, Vol.11, No.14, 1897-1902, 2001. (DOI: 10.1016/S0960-894X(01)00323-7, PubMed: 11459656, Elsevier: Scopus) |
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| 149. | Terrence R Burke-Jr, Jun-Zhu Yao, Bin Ye, Kengo Miyoshi, Akira Otaka, Li Wu and Zhong-Yin Zhang : Phospho-azatyrosine, a less effective protein-tyrosine phosphatase substrate than phosphotyrosine, Bioorganic & Medicinal Chemistry Letters, Vol.11, No.10, 1265-1268, 2001. (DOI: 10.1016/S0960-894X(01)00197-4, PubMed: 11392533, Elsevier: Scopus) |
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| 150. | Hirokazu Tamamura, Makiko Sugioka, Yoshihiko Odagaki, Akane Omagari, Yukiko Kan, Shinya Oishi, Hideki Nakashima, Naoki Yamamoto, Stephen C. Peiper, Nobuyuki Hamanaka, Akira Otaka and Nobutaka Fujii : Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity, Bioorganic & Medicinal Chemistry Letters, Vol.11, No.3, 359-362, 2001. (DOI: 10.1016/S0960-894X(00)00664-8, PubMed: 11212110, Elsevier: Scopus) |
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| 151. | Akira Otaka, Hideaki Watanabe, Etsuko Mitsuyama, Akira Yukimasa, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing organocopper-mediated reduction of γ,γ-difluoro-α,β-enoates, Tetrahedron Letters, Vol.42, No.2, 285-287, 2001. (DOI: 10.1016/S0040-4039(00)01924-9, Elsevier: Scopus) |
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| 152. | Shinya Oishi, Hirokazu Tamamura, Masaki Yamashita, Yoshihiko Odagaki, Nobuyuki Hamanaka, Akira Otaka and Nobutaka Fujii : Stereoselective synthesis of a set of two functionalized (E)-alkene dipeptide isosteres of L-amino acid-L-Glu and L-amino acid-D-Glu, Journal of the Chemical Society, Perkin Transactions 1, 2445-2451, 2001. (DOI: 10.1039/B103833H, Elsevier: Scopus) |
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| 153. | Hirokazu Tamamura, Akane Omagari, Shinya Oishi, Taisei Kanamoto, Naoki Yamamoto, Stephen C. Peiper, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes, Bioorganic & Medicinal Chemistry Letters, Vol.10, No.23, 2633-2637, 2000. (DOI: 10.1016/S0960-894X(00)00535-7, PubMed: 11128640, Elsevier: Scopus) |
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| 154. | Koji Fujimoto, Ryo Hosotani, Yoshiharu Miyamoto, Ryuichiro Doi, Takatomo Koshiba, Akira Otaka, Nobutaka Fujii, Robert D. Beauchamp and Masayuki Imamura : Inhibition of pRb phosphorylation and cell cycle progression by an antennapedia-p16(INK4A) fusion peptide in pancreatic cancer cells, Cancer Letters, Vol.159, No.2, 151-158, 2000. |
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| 155. | Yoshimi Sagawa, Yoshiyuki Yoshimura, Akira Otaka and Takashi Yamauchi : Ca2+-independent activity of Ca2+/calmodulin-dependent protein kinase II involved in stimulation of neurite outgrowth in neuroblastoma cells, Brain Research, Vol.881, No.2, 165-175, 2000. (DOI: 10.1016/S0006-8993(00)02838-9, PubMed: 11036155, Elsevier: Scopus) |
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| 156. | Yoshihiro Kuroda, Kazuhide Miyamoto, Kazufumi Tanaka, Yoshitaka Maeda, J Ishikawa, R Hinata, Akira Otaka, Nobutaka Fujii and Terumichi Nakagawa : Interactions between Local Anesthetics and Na+ Channel Inactivation Gate Peptides in Phosphatidylserine Suspensions as Studied by 1H-NMR Spectroscopy, Chemical & Pharmaceutical Bulletin, Vol.48, No.9, 1293-1298, 2000. |
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| 157. | Yoshihiro Kuroda, Kazuhide Miyamoto, M Matsumoto, Yishitaka Maeda, Kenji Kanaori, Akira Otaka, Nobutaka Fujii and Terumichi Nakagawa : Structural study of the sodium channel inactivation gate peptide including an isoleucine-phenylalanine-methionine motif and its analogous peptide (phenylalanine/glutamine) in trifluoroethanol solutions and SDS micelles, The Journal of Peptide Research, Vol.56, No.3, 172-184, 2000. (DOI: 10.1034/j.1399-3011.2000.00745.x, PubMed: 11007274, Elsevier: Scopus) |
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| 158. | Akira Otaka, Etsuko Mitsuyama, Takayoshi Kinoshita, Hirokazu Tamamura and Nobutaka Fujii : Stereoselective Synthesis of CF2-Substituted Phosphothreonine Mimetics and Their Incorporation into Peptides Using Newly Developed Deprotection Procedures, The Journal of Organic Chemistry, Vol.65, No.16, 4888-4899, 2000. (DOI: 10.1021/jo000169v, PubMed: 10956468, Elsevier: Scopus) |
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| 159. | Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura and Nobutaka Fujii : A New Practical Strategy for the Synthesis of Long-chain Phosphopeptide, Chemical & Pharmaceutical Bulletin, Vol.48, No.88, 1230-1233, 2000. (PubMed: 10959596, Elsevier: Scopus) |
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| 160. | Motoyoshi Nomizu, Yuichiro Kuratomi, M. Lourdes Ponce, Sang Yong Song, Kengo Miyoshi, Akira Otaka, Sharon K. Powell, Matthew P. Hoffman, Hynda K. Kleinman and Yoshihiko Yamada : Cell Adhesive Sequences in Mouse Laminin β1 Chain, Archives of Biochemistry and Biophysics, Vol.378, No.2, 311-320, 2000. (DOI: 10.1006/abbi.2000.1828, PubMed: 10860548, Elsevier: Scopus) |
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| 161. | Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura and Nobutaka Fujii : Development of new methodology for the synthesis of functionalized α-fluorophosphonates and its practical application to the preparation of phosphopeptide mimetics, Chemical Communications, 1081-1082, 2000. (Elsevier: Scopus) |
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| 162. | Yoshihiro Kuroda, Yoshitaka Maeda, Kazuhide Miyamoto, Kazufumi Tanaka, Kenji Kanaori, Akira Otaka, Nobutaka Fujii and Terumichi Nakagawa : 1H-NMR and Circular Dichroism Spectroscopic Studies on Changes in Secondary Structures of the Sodium Channel Inactivation Gate Peptides as Caused by the Pentapeptide KIFMK, Biophysical Journal, Vol.77, No.3, 1363-1373, 1999. |
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| 163. | Hirokazu Tamamura, Masaki Yamashita, Yutaka Nakajima, Kyoko Sakano, Akira Otaka, Hiroaki Ohno, Toshiro Ibuka and Nobutaka Fujii : Regiospecific ring-opening reactions of β-aziridinyl α,β-enoates with acids: application to the stereoselective synthesis of a couple of diastereoisomeric (E)-alkene dipeptide isosteres from a single β-aziridinyl α,β-enoate and to the convenient preparation of amino alcohols bearing α,β-unsaturated ester groups, Journal of the Chemical Society, Perkin Transactions 1, 2983-2996, 1999. |
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| 164. | Shunji Kanaoka, Seiji Yamasaki, Takashi Okino, Naoya Inoue, Yutaka Shimada, Midori Kaneko, Akira Otaka, Nobutaka Fujii and Masayuki Imamura : Induction of human leukocyte antigen (HLA)-A2-restricted and MAGE-3-gene-derived peptide-specific cytolytic T lymphocytes using cultured dendritic cells from an HLA-A2 esophageal cancer patient, Journal of Surgical Oncology, Vol.71, No.1, 16-21, 1999. |
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| 165. | Hirokazu Tamamura, Younong Xu, Toshio Hattori, Xiaoyan Zhang, Rieko Arakaki, Kenji Kanbara, Akane Omagari, Akira Otaka, Toshiro Ibuka, Naoki Yamamoto, Hideki Nakashima and Nobutaka Fujii : A Low-Molecular-Weight Inhibitor against the Chemokine Receptor CXCR4: A Strong Anti-HIV Peptide T140, Biochemical and Biophysical Research Communications, Vol.253, No.3, 877-882, 1998. (DOI: 10.1006/bbrc.1998.9871, PubMed: 9918823, Elsevier: Scopus) |
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| 166. | Motoyoshi Nomizu, Yuichiro Kuratomi, Katherine M. Malinda, Sang Yong Song, Kengo Miyoshi, Akira Otaka, Sharon K. Powell, Matthew P. Hoffman, Hynda K. Kleinman and Yoshihiko Yamada : Cell Binding Sequences in Mouse Laminin 1 Chain, The Journal of Biological Chemistry, Vol.273, No.49, 32491-32499, 1998. |
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| 167. | Hirokazu Tamamura, Makoto Imai, Tsunehito Ishihara, Masao Masuda, Hanae Funakoshi, Hiromi Oyake, Tsutomu Murakami, Rieko Arakaki, Hideki Nakashima, Akira Otaka, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Pharmacophore identification of a chemokine receptor (CXCR4) antagonist, T22 ([Tyr5,12, Lys7]-polyphemusin II), which specifically blocks T cell-line-tropic HIV-1 infection, Bioorganic & Medicinal Chemistry, Vol.6, No.7, 1033-1041, 1998. |
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| 168. | Hirokazu Tamamura, Michinori Waki, Makoto Imai, Akira Otaka, Toshiro Ibuka, Koji Waki, Kenji Miyamoto, Akiyoshi Matsumoto, Tsutomu Murakami, Hideki Nakashima, Naoki Yamamoto and Nobutaka Fujii : Downsizing of an HIV cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-Polyphemusin II), with the maintenance of anti-HIV activity and solution structure, Bioorganic & Medicinal Chemistry, Vol.6, No.4, 473-479, 1998. |
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| 169. | Hirokazu Tamamura, Rieko Arakaki, Hanae Funakoshi, Makoto Imai, Akira Otaka, Toshiro Ibuka, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Effective lowly cytotoxic analogs of an HIV-cell fusion inhibitor, T22 ([Tyr5,12, Lys7]-polyphemusin II), Bioorganic & Medicinal Chemistry, Vol.6, No.2, 231-238, 1998. |
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| 170. | Atsushi Kosaki, Kazunori Yamada, Junko Suga, Akira Otaka and Hideshi Kuzuya : 14-3-3β Protein Associates with Insulin Receptor Substrate 1 and Decreases Insulin-stimulated Phosphatidylinositol 3-Kinase Activity in 3T3L1 Adipocytes, The Journal of Biological Chemistry, Vol.273, No.2, 940-944, 1998. |
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| 171. | Hirokazu Tamamura, F Matsumoto, Kyoko Sakano, Akira Otaka, Toshiro Ibuka and Nobutaka Fujii : Unambiguous Synthesis of Stromal Cell-derived Factor-1 by Regioselective Disulfide Bond Formation Using a DMSO-aqueous HCl System, Chemical Communications, No.1, 151-152, 1998. |
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| 172. | Hirokazu Tamamura, Tsunehito Ishihara, Hiromi Oyake, Makoto Imai, Akira Otaka, Toshiro Ibuka, Rieko Arakaki, Hideki Nakashima, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Convenient one-pot synthesis of cystine-containing peptides using the trimethylsilyl chloride dimethyl sulfoxide/trifluoroacetic acid system and its application to the synthesis of bifunctional anti-HIV compounds1, Journal of the Chemical Society, Perkin Transactions 1, 495-500, 1998. |
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| 173. | Motoyoshi Nomizu, Yuichiro Kuratomi, Sang-Yong Song, M. Lourdes Ponce, Matthew P. Hoffman, Sharon K. Powell, Kengo Miyoshi, Akira Otaka, Hynda K. Kleinman and Yoshihiko Yamada : Identification of Cell Binding Sequences in Mouse Laminin 1 Chain by Systematic Peptide Screening, The Journal of Biological Chemistry, Vol.272, No.51, 32198-32205, 1997. |
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| 174. | Hiroshi Aoyama, Norio Mimura, Hiroaki Ohno, Kiyonori Ishii, Ayako Toda, Hirokazu Tamamura, Akira Otaka, Nobutaka Fujii and Toshiro Ibuka : Regio- and stereoselectivity in reactions of 2,3-cis- and trans-3-alkyl-2-vinylaziridines with organocopper reagents: Importance of 2,3-cis-stereochemistry in controlling selectivity, Tetrahedron Letters, Vol.38, No.42, 7383-7386, 1997. |
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| 175. | Hiroaki Ohno, Norio Mimura, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Toshiro Ibuka, Isao Shimizu, Akiharu Satake and Yoshinori Yamamoto : Palladium-Catalyzed Reductive Ring Opening with Formic Acid of Aziridines Bearing an α,β-Unsaturated Ester Group, Tetrahedron, Vol.53, No.38, 12933-12946, 1997. (DOI: 10.1016/S0040-4020(97)00817-X) |
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| 176. | Hirokazu Tamamura, Masaki Yamashita, Hiroyuki Muramatsu, Hiroaki Ohno, Tohiro Ibuka, Akira Otaka and Nobutaka Fujii : Regiospecific ring-opening reactions of aziridines bearing an α,β-unsaturated ester group with trifluoroacetic acid or methanesulfonic acid: application to the stereoselective synthesis of (E)-alkene dipeptide isosteres, Chemical Communications, 2327-2328, 1997. |
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| 177. | Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Toshiro Ibuka, Kyoko Sakano, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : An Anti-HIV Peptide, T22, Forms a Highly Active Complex with Zn(II), Biochemical and Biophysical Research Communications, Vol.229, No.2, 648-652, 1996. |
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| 178. | Hirokazu Tamamura, Tsunehito Ishihara, Akira Otaka, Tsutomu Murakami, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Analysis of the interaction of an anti-HIV peptide, T22 ([Tyr5, 12, Lys7]-polyphemusin II), with gp120 and CD4 by surface plasmon resonance, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol.1298, No.1, 37-44, 1996. (DOI: 10.1016/S0167-4838(96)00113-6, PubMed: 8948487) |
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| 179. | Motoyoshi Nomizu, Atsushi Utani, Konrad Beck, Akira Otaka, Peter P. Roller and Akira Otaka : Mechanism of Laminin Chain Assembly into a Triple-Stranded Coiled-Coil Structure, Biochemistry, Vol.35, No.9, 2885-2893, 1996. |
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| 180. | Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Tsunehito Ishihara, Toshiro Ibuka, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Interaction of an Anti-HIV Peptide, T22, with GP120 and CD4, Biochemical and Biophysical Research Communications, Vol.219, No.2, 555-559, 1996. |
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| 181. | Joseph J. Barchi-Jr, Motoyoshi Nomizu, Akira Otaka, Peter P. Roller and Terrence R. Burke-Jr : Conformational Analysis of Cyclic Hexapeptides Designed as Constrained Ligands for the SH2 Domain of the p85 Subunit of Phosphatidylinositol-3-OH Kinase., Biopolymers, Vol.38, No.2, 191-208, 1996. (DOI: 10.1002/(SICI)1097-0282(199602)38:2<191::AID-BIP6>3.0.CO;2-Q, PubMed: 8589253) |
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| 182. | Bin Ye, Akira Otaka and Terrence R. Burke-Jr : Preparation of Na-Boc 4-O-Diethylphosphono-L-azatyrosine, a Reagent Potentially Useful for the Synthesis of Signal Transduction Related Peptides., Synlett, 459-460, 1996. |
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| 183. | Li Chen, Li Wu, Akira Otaka, Mark S Smyth, Peter P Roller, Terrence R Burke, Den Jen Hertog and Zhong-Yin Zhang : Why Is Phosphonodifluoromethyl Phenylalanine a More Potent Inhibitory Moiety Than Phosphonomethyl Phenylalanine Toward Protein-Tyrosine Phosphatases, Biochemical and Biophysical Research Communications, Vol.216, No.3, 976-984, 1995. |
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| 184. | Motoyoshi Nomizu, W H. Kim, Keizo Yamamura, Atsushi Utani, Sang-Yong Song, Akira Otaka, Peter P. Roller, Hynda K. Kleinman and Yoshihiko Yamada : Identification of Cell Binding Sites in the Laminin a1 Chain Carboxyl-terminal Globular Domain by Systematic Screening of Synthetic Peptides., The Journal of Biological Chemistry, Vol.270, No.35, 20583-20590, 1995. (PubMed: 7657636, Elsevier: Scopus) |
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| 185. | Hirokazu Tamamura, Tsutomu Murakami, S Horiuchi, K Sugihara, Akira Otaka, W Takada, Toshiro Ibuka, Michinori Waki, Naoki Yamamoto and Nobutaka Fujii : Synthesis of Protegrin-related Peptides and their Antibacterial and Anti-Human Immunodeficiency Virus Activity., Chemical & Pharmaceutical Bulletin, Vol.43, No.5, 853-858, 1995. (PubMed: 7553971) |
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| 186. | Hirokazu Tamamura, Akira Otaka, J Nakamura, K Okubo, T Koide, K Ikeda, Toshiro Ibuka and Nobutaka Fujii : Disulfide Bond-forming Reaction using Dimethyl sulfoxide/aqueous HCl System and Its Application to Regioselective Two Disulfide Bond Formation., International Journal of Peptide and Protein Research, Vol.45, No.4, 312-319, 1995. (PubMed: 7601603) |
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| 187. | Akira Otaka, Kengo Miyoshi, Hideki Kubota, Terrence R. Burke-Jr, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Synthesis and application of N-Boc-L-2-amino-4-(diethylphosphono)-4,4-difluorobutanoic acid for solid-phase synthesis of nonhydrolyzable phosphoserine peptide analogues, Tetrahedron Letters, Vol.36, No.6, 927-930, 1995. |
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| 188. | Ronald L. Wange, Noah Isakov, Terrence Burke R. Jr., Akira Otaka, Peter P. Roller, Julian D. Watts, Ruedi Aebersold and Lawrence E. Samelson : F2(Pmp)2-TAM3, a Novel Competitive Inhibitor of the Binding of ZAP-70 to the T Cell Antigen Receptor, Blocks Early T Cell Signaling, The Journal of Biological Chemistry, Vol.270, No.2, 944-948, 1995. (DOI: 10.1074/jbc.270.2.944, PubMed: 7822334, Elsevier: Scopus) |
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| 189. | Hirokazu Tamamura, Akira Otaka, W Takada, Y Terakawa, H Yoshizawa, Masao Masuda, Toshiro Ibuka, Tsutomu Murakami, Hideki Nakashima, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Solution-phase synthesis of an anti-human immunodeficiency virus peptide, T22 ([Tyr5,12,Lys7]-polyphemusin II), and the modification of Trp by the p-methoxybenzyl group of Cys during trimethylsilyl trifluoromethanesulfonate deprotection., Chemical & Pharmaceutical Bulletin, Vol.43, No.1, 12-18, 1995. |
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| 190. | Akira Otaka, Kengo Miyoshi, Peter P. Roller, Terrence R. Burke-Jr, Hirokazu Tamamura and Nobutaka Fujii : Practical Synthesis of Phosphopeptides Using Dimethyl-protected Phosphoamino Acid Derivatives., Journal of the Chemical Society. Chemical Communications, Vol.3, 387-389, 1995. |
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| 191. | Toshiro Ibuka, Kazuo Nakai, Hiromu Habashita, Yuka Hotta, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yukiyasu Chounan and Yoshinori Yamamoto : Aza-Payne Rearrangement of Activated 2-Aziridinemethanols and 2,3-Epoxy Amines under Basic Conditions., The Journal of Organic Chemistry, Vol.60, No.7, 2044-2058, 1995. |
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| 192. | Nobutaka Fujii, Kazuo Nakai, Hirokazu Tamamura, Akira Otaka, Norio Mimura, Yoshihisa Miwa, Tooru Taga, Yoshinori Yamamoto and Toshiro Ibuka : SN2' Ring opening of aziridines bearing an α,β-unsaturated ester group with organocopper reagents. A new stereoselective synthetic route to (E)-alkene dipeptide isosteres., Journal of the Chemical Society, Perkin Transactions 1, 1359-1371, 1995. |
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| 193. | Kazuo Nakai, Toshiro Ibuka, Akira Otaka, Hirokazu Tamamura, Nobutaka Fujii and Yoshinori Yamamoto : A One-pot Aza-Payne Rearrangement-Epoxide Ring Opening Reaction of 2-Aziridinemethanols: A Regio- and Stereoselective Synthetic Route to Diastereomerically Pure 1,2-Amino Alocohols., Tetrahedron Letters, Vol.36, 6247-6250, 1995. |
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| 194. | Akira Otaka, Kengo Miyoshi, Midori Kaneko, Hirokazu Tamamura, Nobutaka Fujii, Motoyoshi Nomizu, Terrence R. Burke and Peter P. Roller : Development of Efficient Two-Step Deprotection Methodology for Dimethyl-Protected Phosphoamino Acid-Containing Peptide Resins and Its Application to the Practical Synthesis of Phosphopeptides, The Journal of Organic Chemistry, Vol.60, 3967-3974, 1995. |
| 1. | Kohta Hidaka, JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka : Advanced Insulin Synthesis by One-pot/stepwise Disulfide Bond Formation Enabled by Acid-activated S-Protected Cysteine Sulfoxide in the Presence of Chloride Anion, ChemRxiv, 2024. (DOI: 10.26434/chemrxiv-2024-jg5z3) |
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| 2. | Daishiroh Kobayashi, Masaya Denda, JUNYA Hayashi, Kohta Hidaka, Yutaka Kohmura, Takaaki Tsunematsu, Kohei Nishino, Harunori Yoshikawa, OHKAWACHI Kento, Kiyomi Nigorikawa, Tetsuro Yoshimaru, Naozumi Ishimaru, Nomura Wataru, Toyomasa Katagiri, Hidetaka Kosako and Akira Otaka : Sulfoxide-mediated Cys-Trp-selective bioconjugation that enables protein labeling and peptide heterodimerization, ChemRxiv, 2024. (DOI: 10.26434/chemrxiv-2024-tkv7w-v2) |
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| 3. | Kaito Anzaki, OHKAWACHI Kento, Daishiroh Kobayashi, Kyan Ryuji, Masaya Denda, Akira Shigenaga and Akira Otaka : Residue-Specific Modification Reaction Using S-Acetamidomethyl Cysteine Sulfoxide, Cys(Acm)(O), Peptide Science 2021, 55-56, 2022. |
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| 4. | Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka : Development of copper and iron-mediated Cys-Trp-linking reaction, Peptide Science 2021, 9-12, 2022. |
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| 5. | OHKAWACHI Kento, Daishiroh Kobayashi, Kyohei Morimoto, Akira Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai and Akira Otaka : A New Thiol Additive for One-pot Sequential Peptide Ligation-Desulfurization Chemistry, Peptide Science 2020, 25-26, 2021. |
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| 6. | Daishiroh Kobayashi, Naoto Naruse, Masaya Denda, Akira Shigenaga and Akira Otaka : Deprotection of S-Acetamidomethyl Cysteine Mediated by Copper Salts, Peptide Science 2020, 49-52, 2021. |
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| 7. | Daishiroh Kobayashi, Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Lossen rearrangement-mediated preparation of N-glyoxylyl peptide without addition of oxidant, Peptide Science 2019, 59, 2020. |
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| 8. | Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis, Peptide Science 2018, 8, 2019. |
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| 9. | Taiki Kohiki, Yusuke Kato, Masaya Denda, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka : Development and application of novel protein labeling reagent "SEAL", Peptide Science 2018, 104, 2019. |
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| 10. | Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka : Development of anti-cancer peptide based on prohibitin 2, Peptide Science 2018, 46, 2019. |
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| 11. | Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, Kenzo Yamatsugu, Akira Shigenaga, Motomu Kanai and Akira Otaka : Development of methodology for cyclic peptide synthesis using a thiol-incorporated DMAP catalyst, Peptide Science 2018, 81, 2019. |
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| 12. | Naoto Naruse, Kiyoka Matsumoto, Akira Shigenaga and Akira Otaka : Development of method for deprotection of N-terminal thiazolidine derivative using copper salt for chemical protein synthesis, Peptide Science 2018, 80, 2019. |
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| 13. | Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis, Peptide Science 2017, 32-33, 2018. |
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| 14. | Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, Kenji Uchimura, Kumiko Sakai-Kato, Akira Shigenaga, Toru Kawakami, Akira Otaka, Hironobu Hojo, Naomi Sakashita and Hiroyuki Saito : Sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides via enthalpy-driven interactions, Peptide Science 2016, 141-142, 2017. |
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| 15. | Shiho Mikawa, Chiharu Mizuguchi, Izumi Morita, Hiroyuki Oyama, Teruhiko Baba, Akira Shigenaga, Toshinori Shimanouchi, Norihiro Kobayashi, Akira Otaka, Kenichi Akaji and Hiroyuki Saito : Effect of heparin on amyloid fibril formation of apoA-I fragment peptides, Peptide Science 2016, 149-151, 2017. |
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| 16. | Yukihiro Itoh, Keisuke Aihara, Paolo Mellini, Toshifumi Tojo, Yosuke Ota, Hiroki Tsumoto, Viswas Raja Solomon, Peng Zhan, Miki Suzuki, Daisuke Ogasawara, Akira Shigenaga, Tsubasa Inokuma, Hidehiko Nakagawa, Naoki Miyata, Tamio Mizukami, Akira Otaka and Takayoshi Suzuki : Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors, Peptide Science 2016, 165-166, 2017. |
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| 17. | Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : One-pot sequential native chemical ligations using photocaged crypto-thioester, Peptide Science 2016, 73-74, 2017. |
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| 18. | Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : Development of N-sulfanyltehylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins, Peptide Science 2016, 179-181, 2017. |
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| 19. | Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma and Akira Otaka : Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library, Peptide Science 2016, 75-76, 2017. |
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| 20. | Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Intein-inspired amide bond processing device, EPS Proceedings 2016, 60, 2016. |
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| 21. | Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma, Kouji Itou and Akira Otaka : Second-generation synthetic strategy of GM2-activator protein (GM2AP) analogues applicable to the preparation of a protein library, EPS Proceedings 2016, 63, 2016. |
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| 22. | Keisuke Aihara, Kohsuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : One-pot/sequential native chemical ligation using photo-responsive crypto-thioester, EPS Proceedings 2016, 39, 2016. |
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| 23. | Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol, Peptide Science 2015, 21-22, 2016. |
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| 24. | Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of intein-inspired peptide bond processing device, Peptide Science 2015, 281-282, 2016. |
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| 25. | Kohei Tsuji, Kohei Sato, Mitsuhiro Eto, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : N-Sulfanylethylanilide (SEAlide) peptide as a versatile intermediate for protein chemical synthesis using native chemical ligation, Peptide Science 2014, 113-116, 2015. |
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| 26. | Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : Development of thiol-responsive traceable linker for efficient enrichment and selective labeling of target proteins, Peptide Science 2013, 205-206, 2014. |
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| 27. | Keisuke Aihara, Akira Shigenaga, Daisuke Takahashi and Akira Otaka : New approach for synthesis of lactam bridged peptides using olefin metathesis on AJIPHASE®, Peptide Science 2013, 143-144, 2014. |
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| 28. | Miku Kita, Jun Yamamoto, Koji Ebisuno, Chiaki Komiya, Akira Shigenaga, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka : Development of hydrogen peroxide-responsive amide bond cleavage device, Peptide Science 2013, 203-204, 2014. |
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| 29. | Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura and Akira Otaka : Development of chemical protocols for producing peptide thioesters from naturally occurring peptide sequences, Peptide Science 2013, 157-158, 2014. |
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| 30. | Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto and Akira Otaka : Application of peptidyl prolyl thioesters to native chemical ligation, Peptide Science 2013, 93-94, 2014. |
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| 31. | Ken Sakamoto, Kohei Sato, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : N-Sulfanylethyl anilide linkers as peptide thioester equivalent, Peptides Across The Pacific, Proceedings of the Twenty-Third American and Sixth International Peptide Symposium, 242-243, 2013. |
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| 32. | Akira Shigenaga, Keiji Ogura, Hiroko Hirakawa, Jun Yamamoto, Koji Ebisuno, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka : Design and synthesis of hypoxia-responsive amino acid which causes peptide bond cleavage in hypoxic cells, Peptide Science 2012, 135-136, 2013. (CiNii: 1570854176180146304) |
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| 33. | Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : Convergent chemical synthesis of human GM2 activator protein analog using SEAlide chemistry, Peptide Science 2012, Vol.2012, 13-14, 2013. (CiNii: 1571135651156844416) |
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| 34. | Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Masaya Denda, Hao Ding, Takahiko Hara and Akira Otaka : Synthesis of antagonistic peptide for putative CXCL14 receptor protein and their identification, Peptide Science 2012, Vol.2012, 31-32, 2013. (CiNii: 1571980076086973440) |
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| 35. | Ken Sakamoto, Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Hajime Hibino, Yuji Nishiuchi and Akira Otaka : Development of efficient synthetic protocol for Fmoc amino acid-incorporated N-sulfanylethyl-aniline linker as peptide thioester precursor, Peptide Scinece 2012, Vol.2012, 165-166, 2013. (CiNii: 1572261551063693056) |
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| 36. | Akira Shigenaga, Hiroko Hirakawa, Jun Yamamoto, Keiji Ogura, Masaya Denda, Keiko Yamaguchi and Akira Otaka : Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer, Peptide Science 2011, 385-386, 2012. (CiNii: 1570572700793231232) |
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| 37. | Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka : Doubly-kinetically controlled proline ligation, Peptide Science 2011, 133-134, 2012. (CiNii: 1570854175769778944) |
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| 38. | Kohei Sato, Shugo Tsuda, Ken Sakamoto, Akira Shigenaga and Akira Otaka : N-Sulfanylethylanilide peptide: a peptide thioester equivalent which can directly participate in native chemical ligation, Peptide Science 2011, 13-14, 2012. (CiNii: 1570009750839756800) |
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| 39. | Kohei Sato, Shugo Tsuda, Kohei Tsuji, Ken Sakamoto, Akira Shigenaga and Akira Otaka : N-Sulfanylethylanilide derivative as a peptide thioester equivalent, Proceedings of the Twenty-Second American Peptide Symposium, 72-73, 2011. |
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| 40. | Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol, Proceedings of the Twenty-Second American Peptide Symposium, 74-75, 2011. |
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| 41. | Akira Otaka and Akira Shigenaga : Development of amide bond cleavage device with application to chemical biology use, Peptide Science 2010, Vol.2010, No.0, 49, 2011. (CiNii: 1572261550741345024) |
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| 42. | Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : Synthesis and biological evaluation of CXCL14 and its derivatives, Peptide Science 2010, Vol.2010, No.0, 182, 2011. (CiNii: 1573105975671357056) |
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| 43. | Akira Shigenaga, Jun Yamamoto, Naomi Nishioka, Masaya Denda and Akira Otaka : Enantioselective synthesis of stimulus-responsive amino acid via pyrrolidinyl tetrazole catalyzed asymmetric -amination of aldehyde, Peptide Science 2010, Vol.2010, No.0, 202, 2011. (CiNii: 1572824500694759936) |
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| 44. | Kohei Sato, Shugo Tsuda, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka : Native chemical ligation using N-peptidyl anilide as crypto-thioester, Peptide Science 2010, Vol.2010, No.0, 203, 2011. (CiNii: 1573950400601602304) |
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| 45. | Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka : Synthesis of nonhydrolyzable AMPylated amino acid analogues for uncovering the physiological role of AMPylation, Peptide Science 2010, Vol.2010, No.0, 205, 2011. (CiNii: 1570854175857789184) |
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| 46. | Jun Yamamoto, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka : Development of recapturable cleavable linker for efficient enrichment and specific labeling of target proteins, Peptide Science 2010, Vol.2010, No.0, 232, 2011. (CiNii: 1573668925624452736) |
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| 47. | Ko Morishita, Keiko Yamaguchi, Hao Ding, Akira Shigenaga, Kenichi Akaji and Akira Otaka : Development of stimulus responsive thiol releasing system for controlling activity of cysteine protease, Peptide Science 2010, Vol.2010, No.0, 290, 2011. (CiNii: 1573950400601248256) |
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| 48. | Akira Shigenaga, Yukiko Nishiyama, Nami Maeda and Akira Otaka : Synthesis of cyclic peptides via on resin-intramolecular native chemical ligation followed by reductive release from resin, Peptide Science 2009, 147-148, 2010. |
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| 49. | Akira Shigenaga, Naomi Nishioka, Jun Yamamoto, Hiroko Hirakawa, Yoshitake Sumikawa, Keiko Yamaguchi and Akira Otaka : Influence of an amino acid sequence on kinetics of peptide bond cleavage reaction induced by a stimulus-responsive amino acid, Peptide Science 2008, 395-396, 2009. |
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| 50. | Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka : The application of peptide thioacids to NCL-type sequential condensation of peptide fragments, Peptide Science 2008, 175-176, 2009. |
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| 51. | Yoko Yamaki, Akira Shigenaga and Akira Otaka : Synthesis of fluoroalkene dipeptide isostere utilizing intramolecular redox reaction, Peptide Science 2008, 49-50, 2009. |
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| 52. | Shugo Tsuda, Nami Maeda, Kiyomi Bando, Akira Shigenaga and Akira Otaka : Synthesis of peptide thioester using N-substituted aniline derivatives, Peptide Science 2008, 17-18, 2009. |
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| 53. | Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka : Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application to a nucleocytoplasmic shuttle peptide, Peptide Science 2007, Vol.2007, 97-98, 2008. (CiNii: 1573950400368902528) |
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| 54. | Yoshikazu Sasaki, Takashi Tsuji, Ayumu Niida, Akira Shigenaga, Nobutaka Fujii and Akira Otaka : Regio- and stereoselective synthesis of (Z)-alkene cis-Xaa-Pro dipeptide mimetics, Peptides 2006, 126-127, 2007. |
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| 55. | Takashi Tsuji, Yoshikazu Sasaki, Keiko Yamaguchi, Akira Shigenaga, Nobutaka Fujii and Akira Otaka : Synthesis of (Z)-alkene cis-Xaa-Pro type dipeptide isosteres using organocopper-mediated anti-SN2' reactions, Peptide Science 2006, 327, 2006. |
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| 56. | Akira Shigenaga, Saori Shintaku and Akira Otaka : Development of photo-responsive self-processing peptides, Peptide Science 2006, 92, 2006. |
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| 57. | Satoshi Ueda, Akira Otaka, Hirokazu Tamamura and Nobutaka Fujii : 4-(Dimethylamino)phenacyl Group: New Photoremovable Protecting Group for Amines and Carboxylic Acids, Peptide Science 2004, Vol.2004, 599-602, 2005. (CiNii: 1570854174923822592) |
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| 58. | Terukazu Kato, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere and their Structure-activity Relationship Studies, Peptide Science 2004, Vol.2004, 515-516, 2005. (CiNii: 1570854174923778176) |
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| 59. | Hirokazu Tamamura, Takanobu Araki, Ai Esaka, Satoshi Ueda, Shinya Oishi, Zixuan Wang, Stephen C. Peiper, Akira Otaka and Nobutaka Fujii : Development of Low Molecular Weight CXCR4 Antagonists by Exploratory Structural Tuning of Cyclic Tetrapeptide-scaffolds, Peptide Science 2004, Vol.2004, 509-510, 2005. (CiNii: 1572824499760752512) |
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| 60. | Hirokazu Tamamura, Kenichi Hiramatsu, Satoshi Ueda, Takanobu Araki, M Takenaga, R Igarashi, Akira Hori, Naoyuki Kanzaki, Miho Fujisawa, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : The Chemokine Receptor CXCR4 as a Therapeutic Target for Several Diseases Including AIDS, Cancer and Rheumatoid Arthritis, Peptide Science 2004, Vol.2004, 121-122, 2005. (CiNii: 1573105974741577856) |
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| 61. | Ayumu Niida, Makiko Mizumoto, Yoshikazu Sasaki, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of Diketopiperazine Mimmetics as Promising Scaffolds for Drug Discovery Utilizing Organocopper-Mediated anti-SN2' Reaction, Peptide Science 2004, 169-172, 2005. |
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| 62. | S Mizokami, Hirokazu Tamamura, Kenichi Hiramatsu, Makiko Mizumoto, Miki Akamatsu, Hideki Nakashima, Zixuan Wang, Stephen C. Peiper, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : New Leads of Low Molecular Weight CXCR4 Antagonists Based on Enhancement of the T140-based Pharmacophores, Peptide Science 2003, Vol.2003, No.0, 285-288, 2004. (CiNii: 1574231874864552704) |
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| 63. | Terukazu Kato, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Development of Potent β-Secretase Inhibitors Containing a Hydroxyethylamine Dipeptide Isostere, Peptide Science 2003, Vol.2003, No.0, 231-234, 2004. (CiNii: 1572824499981164288) |
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| 64. | Hirokasu Tamamura, Akira Hori, Naoyuki Kanzaki, Kenichi Hiramatsu, Makiko Mizumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : CXCR4 Antagonists Identified as Anti-Cancer Metastatic Agents, Peptide Science 2003, Vol.2003, No.0, 65-68, 2004. (CiNii: 1573950399887592448) |
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| 65. | Takanobu Araki, Satoshi Ueda, Kenichi Hiramatsu, Shinya Oishi, Hirokazu Tamamura, Akira Otaka, Nobutaka Fujii, Shuichi Kusano, Shigemi Terakubo, Hideki Nakashima, Zixuan Wang and Stephen C. Peiper : A New Strategy for Molecular-size Reduction Bioactive Peptide, Using Two Orthogonal Libraries of Cyclic Peptided, Peptide Science 2003, 207-210, 2004. |
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| 66. | Satoshi Ueda, Kenji Tomita, Akira Otaka, Hirokazu Tamamura, Yoshiaki Yano, Katsumi Matsuzaki and Nobutaka Fujii : Synthesic Studies on 7TM-GPCR (I):Lipid Bilayer Assisted Membrane Peptide Ligation, Peptide Science 2003, Vol.40, 53-56, 2004. |
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| 67. | Akira Otaka, Yoshikazu Sasaki, Fumihiko Katagiri, Shinya Oishi, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of(E)-Alkene trans-Xaa-Pro Mimetics Using Organocopper Reagents, Peptide Science 2002, Vol.2002, No.0, 357-360, 2003. (CiNii: 1570009751822974592) |
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| 68. | Kenichi Hiramatsu, Hirokazu Tamamura, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Synthesis of CXCR4 Antagonists,T140 Derivatives with Improved Biostability, and Their SAR Study, Peptide Science 2002, Vol.2002, No.0, 213-216, 2003. (CiNii: 1573387451543475456) |
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| 69. | Akira Otaka, Miki Nakamura, Eiichi Kodama, Syota Nakamura, Hiroaki Nakano, Susumu Uchiyama, Hirokazu Tamamura, Masao Matsuoka, Yuji Kobayashi and Nobutaka Fujii : Development of Fusion-inhibiting Anti-HIV-1 Peptides Based on the Structure of Molecular Complex Involved in HIV-1-cell Fusion, Peptide Science 2002, Vol.2002, No.0, 65-68, 2003. (CiNii: 1573105976559944192) |
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| 70. | Hirokazu Tamamura, Terukazu Kato, Tadakazu Hori, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of Peptidomimetics with Hydroxyethylamine Diepetide Isosteres Utilizing Aza-Payne Rearrangement and O,N-Acyl Transfer Reactions, Peptide Science 2002, 143-146, 2003. |
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| 71. | K Nemoto, Hirokazu Tamamura, S Mizokami, Shinya Oishi, Akira Otaka and Nobutaka Fujii : Acid-catalyzed Ring-opening Reactions of β-Aziridinyl-α,β-enoates and Their Application, Peptide Science 2002, 139-142, 2003. |
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| 72. | K. Takeshima, A. Chikushi, S Kobayashi, L. Kyung-Kwon, S Yonehara, Akira Otaka, Nobutaka Fujii and K Matsuzaki : Translocation of Basic Peptides through Human Cell Membranes, Peptide Science 2001, Vol.2001, No.0, 321-324, 2002. (CiNii: 1572824499551973120) |
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| 73. | Shinya Oishi, Takae Kamano, Ayumu Niida, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type Dipeptide Isosteres and Their Application to a Cyclic RGD Peptide, Peptide Science 2001, Vol.2001, No.0, 241-244, 2002. (CiNii: 1571980074621882880) |
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| 74. | Miki Nakamura, Akira Otaka, Eiichi Kodama, Masao Matsuoka, Susumu Uchiyama, Syota Nakamura, Yuji Kobayashi, Hirokazu Tamamura and Nobutaka Fujii : Design and Synthesis of Highly Active Anti-HIV Peptide Based on gp41-C34 Peptide, Peptide Science 2001, Vol.2001, No.0, 73-76, 2002. (CiNii: 1573105974528834048) |
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| 75. | Junko Watanabe, Akira Otaka, Hideaki Watanabe, Akira Yukimasa, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organocopper or SmI2 Reagents, Peptide Science 2001, Vol.2001, No.0, 29-32, 2002. (CiNii: 1574231874435524736) |
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| 76. | Ayumu Niida, Shinya Oishi, Takae Kamano, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of ψ[(E)-CMe=CMe]- and ψ[(E)-CMe=CH]-type Alkene Dipeptide Isosteres from a Chiral Amino Acide, Peptide Science 2001, 237-240, 2002. |
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| 77. | Kenichi Hiramatsu, Hirokazu Tamamura, Akane Omagari, Hideki Nakashima, Younong Xu, Masao Matsuoka, Akira Otaka and Nobutaka Fujii : Synthesis of Novel Anti-HIV Peptides Based on a CXCR4 Antagonist, T140, and Their SAR Study, Peptide Science 2001, 175-178, 2002. |
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| 78. | Akira Otaka, Miki Nakamura, Eiichi Kodama, Susumu Uchiyama, Hirokazu Tamamura, Yuji Kobayashi, Masao Matsuoka and Nobutaka Fujii : Artificial Remodeling of gp41-C34 Peptide Leads to Effective HIV Fusion Inhibitor with High anti-HIV Activity, Peptide 2002, 838-839, 2002. |
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| 79. | Shinya Oishi, Takae Kamano, Ayumu Niida, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Organocopper-mediated Stereoselective Synthesis of multi-Substituted Alkene Dipeptide Isosteres and Application to cyclic RGD Peptides, Peptide 2002, 244-245, 2002. |
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| 80. | Shinya Oishi, Takae Kamano, Ayumu Niida, M. Kwaguchi, Ryo Hosotani, Masayuki Imamura, N. Yawata, Keiichi Ajito, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Efficient Synthesis of Cyclic RGD Pseudopeptide with (E)-Alkene Dipeptide Isosteres and Its Biological Activity, Peptide Science 2000, 249-250, 2001. |
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| 81. | Akane Omagari, Hirokazu Tamamura, Shinya Oishi, Hideki Nakashima, Akira Otaka and Nobutaka Fujii : Development of Specific CXCR4 Inhibitors Based on an anti-HIV peptide, T140, and Their Structure-Activity Relationship Study, Peptide Science 2000, 129-132, 2001. |
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| 82. | Akira Otaka, Etsuko Mitsuyama, Hideaki Watanabe, Hirokazu Tamamura, T Hayashi, K. Nakao and Nobutaka Fujii : Stereoselective Synthesis of CF2 or CHF-Substituted Phosphoamino Acids and Their Incorporation into Peptide, Peptide Science 2000, 17-20, 2001. |
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| 83. | Akira Otaka, Hideaki Watanabe, Junko Watanabe, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of Fluoroalkene Dipeptide Isosteres Utilizing Organometallic Reagents, Peptides: The Wave of the Future, 606-607, 2001. |
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| 84. | Akira Otaka, Y. Umeda, Shinya Oishi, Toshiro Ibuka and Nobutaka Fujii : New Strategy for the Synthesis of Aspartyl Protease Inhibitor Based on "Aza-Payne Rearrangement", Peptide Science 1999, 195-196, 2000. |
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| 85. | Nobutaka Fujii, M Hirohashi, Shinya Oishi, M Akaji, Akane Omagari, Akira Otaka and Toshiro Ibuka : Application of Ring Closing Olefin Metathesis to the Conformational Restriction of Biological Active Peptide, Peptide Science 1999, 193-194, 2000. |
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| 86. | Motoyoshi Nomizu, Yuichiro Kuratomi, Akira Otaka, Hynda K. Kleinman, Yoshihiko Yamada and Norio Nishi : Identification of Biologically Active Peptides in Laminin-1, Peptide Science 1999, 21-24, 2000. |
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| 87. | M Hirohashi, Shinya Oishi, Tsutomu Murakami, Rieko Arakaki, Younong Xu, Toshio Hattori, Naoki Yamamoto, Takatomo Koshiba, Ryo Hosotani, Masayuki Imamura, T Mio, S Nagai, T Izumi, Hirokazu Tamamura, Akira Otaka and Nobutaka Fujii : Synthesis of a CC Chemokine vMIP-II,Encoded by Kaposi's Sarcoma-associated Herpesvirus and Its Biological Activity, Peptide Science 1998, 285-288, 1999. |
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| 88. | Akira Otaka, Etsuko Mitsuyama, Kengo Miyoshi and Nobutaka Fujii : Synthesis of Nonhydrolyzable Phosphthreonine Derivatives and Their Practical Application to Peptide Synthesis, Peptide Science 1998, 137-140, 1999. |
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| 89. | Hirokazu Tamamura, Akane Omagari, Tsutomu Murakami, Rieko Arakaki, Younong Xu, Toshio Hattori, Michinori Waki, Akiyoshi Matsumoto, Hideki Nakashima, Naoki Yamamoto, Akira Otaka and Nobutaka Fujii : HIV-cell Fusion Inhibitors:T22 and Its Downsized Analogs with High Activity, Peptide Science 1998, 49-52, 1999. |
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| 90. | Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura and Nobutaka Fujii : Convenient Preparation of Phosphopeptide Fagments Using High TFMSA System and Its Application to Synthesis of Long Chain Phosphopeptides, Peptide Science Present and Future, 507-509, 1999. |
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| 91. | Akira Otaka, Y. Umeda, Hirokazu Tamamura, Toshiro Ibuka and Nobutaka Fujii : Synthesis of Protected 2,3-Epoxy Amines Utilizing Aza-Payne Rearrangement of Activated 2-Aziridinemethanols Under Basic Conditions, Peptide Science Present and Future, 504-506, 1999. |
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| 92. | Hirokazu Tamamura, Michinori Waki, Akira Otaka, Tsutomu Murakami, Hideki Nakashima, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Efficient Analog of An Anti-HIV Peptide,T22 ([Tyr5,12,Lys7]-polyphemusin II),Having Low Cytotoxicity, Peptide Science Present and Future, 427-429, 1999. |
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| 93. | Hirokazu Tamamura, Michinori Waki, Akira Otaka, Tsutomu Murakami, Hideki Nakashima, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : HIV-cell Fusin Inhibitor T22([Tyr5,12,Lys7]-polyphemusin II),and Its Related Compounds, Peptide Science Present and Future, 424-426, 1999. |
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| 94. | Hirokazu Tamamura, F Matsumoto, Kyoko Sakano, Akira Otaka, Tsutomu Murakami, Hideki Nakashima, Michinori Waki, Akiyoshi Matsumoro, Naoki Yamamoto and Nobutaka Fujii : An Anti-HIV Peptide T22 is Confirmed to Be a Selective CXCR4/Fusin Inhibitor by Comparative Inhibition Study of a Chemokine SDF-1,Synthesized by Regioselective Disulfide Bond Formation, Peptide Science Present and Future, 398-402, 1999. |
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| 95. | Hirokazu Tamamura, Masaki Yamashita, Hiroyuki Muramatsu, Toshiro Ibuka, Akira Otaka and Nobutaka Fujii : Stereoselctive Synthesis of Two Type (E)-Alkene Dipeptide Isosteres from a Single Substrate of β-Aziridinyl-α ,β-enoate, Peptide Science Present and Future, 44-46, 1999. |
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| 96. | Hirokazu Tamamura, Tsunehito Ishihara, Hiromi Oyake, Akira Otaka and Nobutaka Fujii : Convenient One-pot Synthesis of Cystine-containing Peptides from Protected Peptidyl Resins and Its Application to the Synthesis of Bifunctional Anti-HIV Compounds, Peptide Science Present and Future, 41-43, 1999. |
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| 97. | H. Mariko, Hirokazu Tamamura, Akira Otaka, Toshiro Ibuka, Rieko Arakaki, Hideki Nakashima and Nobutaka Fujii : Ring-closing Metathesis Produced a CXCR4 Antagonist with Anti-HIV Activity, Peptide 1998, 662-663, 1999. |
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| 98. | Akira Otaka, Etsuko Mitsuyama, Shinya Oishi, Kengo Miyoshi, Hirokazu Tamamura and Nobutaka Fujii : Synthesis of Nonhydrolyzable Phosphothreonine Mimetic and Its Practical Application to Peptide Synthesis, Peptide 1998, 264-265, 1999. |
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| 99. | Akira Otaka, Kengo Miyoshi, Midori Kaneko, Terrence Jr R. Burke, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Development of New Efficient Deprotecting Methodologies for The Synthesis of Phosphoamino Acids-Containing Peptides, Peptides 1996, 701-702, 1998. |
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| 100. | Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Identification of a Polyphemusin Analog (T22)- Zn(II) complex by Mass Spectrometric Analysis and Its Anti-HIV Activity, Peptide Chemistry 1996, 269-272, 1997. |
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| 101. | W Takada, Akira Otaka, Kazuo Nakai, Toshiro Ibuka, Koji Fujimoto, M Wada, Ryuichiro Doi, Ryo Hosotani, S Higashide, Masayuki Imamura and Nobutaka Fujii : Synthesis and Biological Activity of Bombesin Analogues Containing (E)-Alkene Dipeptide Isosteres, Peptide Chemistry 1995, 493-496, 1996. |
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| 102. | Hirokazu Tamamura, Akira Otaka, Tsutomu Murakami, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Identification of Binding Proteins of an Anti-HIV Peptide,T22, Peptide Chemistry 1995, 237-240, 1996. |
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| 103. | Kengo Miyoshi, Akira Otaka, Midori Kaneko, Hirokazu Tamamura and Nobutaka Fujii : Practical Phosphopeptides Synthesis Using Dimethylphosphono Amino Acids (No.2), Peptide Chemistry 1995, 25-28, 1996. |
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| 104. | Motoyoshi Nomizu, Atsushi Utani, Akira Otaka, Peter P. Roller and Yoshihiko Yamada : Assembly and Stability of Double- and Triple-stranded α-Helical Coiled-coil Structures of Laminin Peptides, Peptides: Chemistry, Structure and Biology, 487-488, 1996. |
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| 105. | Akira Otaka, Kengo Miyoshi, Hirokazu Tamamura, Peter P. Roller, Terrence R. Burke-Jr and Nobutaka Fujii : Development of a Practical Synthetic Methodology Using Dimethylphosphono Amino Acid for Phosphopeptides, Peptides: Chemistry, Structure and Biology, 442-443, 1996. |
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| 106. | Hirokazu Tamamura, K Sugihara, Akira Otaka, Tsutomu Murakami, S Horiuchi, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Synthesis of Protegrin-related Peptides and their Antibacterial and Anti-HIV Activity., Peptide Chemistry 1994, 345-348, 1995. |
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| 107. | Akira Otaka, Kengo Miyoshi, Terrence R. Burke-Jr, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Application of Ser(OPO3Me2) Derivatives to The Synthesis of Phosphoserine-containing peptide, Peptide Chemistry 1994, 193-196, 1995. |
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| 108. | K. Suzuki, Toshiro Ibuka, Tooru Taga, Yoshihisa Miwa, Norio Mimura, Akira Otaka and Nobutaka Fujii : Stereoselective Synthesis of L-Vinylglycine Derivatives, Peptide Chemistry 1994, 165-168, 1995. |
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| 109. | Hirokazu Tamamura, Y Terakawa, Masao Masuda, Akira Otaka, H Murakami, Hideki Nakashima, S Horiuchi, Michinori Waki, Akiyoshi Matsumoto, Naoki Yamamoto and Nobutaka Fujii : Structure-Activity Relationships of An Anti-HIV Peptide, T-22(No.2), Peptide Chemistry 1994, 153-156, 1995. |
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| 110. | Akira Otaka, Kengo Miyoshi, Terrence R. Burke-Jr, Peter P. Roller, Hirokazu Tamamura and Nobutaka Fujii : Synthesis and Biological Activity of Phosphatases Resistant Phosphoamino Acid Mimetics Containing Peptides, Peptide Chemistry 1994, 9-12, 1995. |
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| 111. | Nobutaka Fujii, Kazuo Nakai, Hiromu Habashita, Akira Otaka, Toshiro Ibuka, N Wada, Ryuichiro Doi, Ryo Hosotani, Masayuki Imamura, F Garrido, A Mann, Yukiyasu Chounan and Yoshinori Yamamoto : Highly Stereoselective Synthesis of (E)-Alkene Dipeptide Isosters via Organocopper Mediated 1,3-Chirality Transfer Reaction and Its Application to The Synthesis of Potent Bombesin Antagonist with No Agonistic Activity, Peptide 1994, 77-78, 1995. |
| 1. | Masaya Denda and Akira Otaka : Advances in Preparation of Peptide and Protein Thioesters Aiming to Use in Medicinal Sciences, Chemical & Pharmaceutical Bulletin, Vol.70, No.5, 316-323, May 2022. (DOI: 10.1248/cpb.c21-01019) |
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| 2. | Akira Shigenaga and Akira Otaka : 有機化学的視点からの標的タンパク質精製・機能解明ツールの開発, Seikagaku, Vol.91, No.6, 795-799, Dec. 2019. (DOI: 10.14952/SEIKAGAKU.2019.910795) |
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| 3. | Akira Otaka : 弁証法的薬学教育観-薬学における有機化学教育を考える-, Journal of Synthetic Organic Chemistry, Japan, Vol.76, No.7, 667, Jul. 2018. (DOI: 10.5059/yukigoseikyokaishi.76.667) |
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| 4. | Akira Otaka and Akira Shigenaga : 十字路:Native Chemical Ligation法, Journal of Synthetic Organic Chemistry, Japan, Vol.76, No.1, 66, Jan. 2018. (DOI: 10.5059/yukigoseikyokaishi.76.66) |
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| 5. | Akira Otaka and Akira Shigenaga : 天然に学ぶタンパク質合成化学, Journal of Synthetic Organic Chemistry, Japan, Vol.76, No.1, 45-54, Jan. 2018. (DOI: 10.5059/yukigoseikyokaishi.76.45) |
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| 6. | 鳴海 哲夫 and Akira Otaka : 第3章 第3節 ペプチドの不安定性を解決するペプチド結合の置換技術, ペプチド医薬品のスクリーニング・安定化・製剤化技術, 130-140, Dec. 2017. |
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| 7. | Akira Shigenaga, Jun Yamamoto, Taiki Kohiki, Tsubasa Inokuma and Akira Otaka : Invention of stimulus-responsive peptide-bond-cleaving residue (Spr) and its application to chemical biology tools, Journal of Peptide Science, Vol.23, 505-513, Aug. 2017. (Tokushima University Institutional Repository: 111930, DOI: 10.1002/psc.2961, PubMed: 28105728) |
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| 8. | Yusuke Tsuda, Akira Shigenaga, Kouhei Satou, Takahiro Nakamura, Keisuke Kitakaze, Tsubasa Inokuma, Kouji Itou and Akira Otaka : 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発, ケミカルバイオロジー, Vol.9, 7-10, Jun. 2016. |
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| 9. | Akira Otaka, Kohei Sato and Akira Shigenaga : Chemical synthesis of proteins using N-sulfanylethylanilide peptides, based on N-S acyl transfer chemistry, Topics in Current Chemistry, Vol.363, 33-56, May 2015. (DOI: 10.1007/128_2014_586, PubMed: 25467538) |
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| 10. | Takahiro Nakamura, Kouhei Satou and Akira Otaka : タンパク性医薬品開発に向けたペプチド化学, 化学工業(特集 ペプチド化学の新潮流(1)), Vol.65, No.11, 842-848, Nov. 2014. (CiNii: 1521417754728344960) |
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| 11. | Akira Shigenaga and Akira Otaka : Development of Stimulus-responsive Amino Acids that are Potentially Applicable to Chemical Biology Use, 化学工業(特集 ペプチド化学の新潮流(1)), Vol.65, No.11, 849-856, Nov. 2014. (Tokushima University Institutional Repository: 111953, CiNii: 1050564287420872448) |
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| 12. | Kohei Sato and Akira Otaka : Development of Chemical Platform for Peptide/Protein-based Drug Discovery, Chemical Industry, Vol.65, No.6, 411-417, Jun. 2014. (CiNii: 1521136280904574080) |
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| 13. | Masaya Denda, Jun Yamamoto, Kouhei Satou, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Yoshiyuki Yoshimura, Aiko Yamauchi and Akira Otaka : 新規タンパク質選択的ラベル化試薬''SEAL-tag''の開発研究, ケミカルバイオロジー, Vol.6, 6-9, Jun. 2013. |
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| 14. | Akira Otaka : Development of Organic and Bio-organic Methodologies for the Synthesis of Proteins, Journal of Synthetic Organic Chemistry, Japan, Vol.70, No.10, 1054, Oct. 2012. (DOI: 10.5059/yukigoseikyokaishi.70.1054, CiNii: 1390282680316668032) |
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| 15. | Akira Otaka, Kohei Sato, Hao Ding and Akira Shigenaga : One-pot/sequential native chemical ligation using N-sulfanylethylanilide peptide, Chemical Record, Vol.12, No.5, 479-490, Aug. 2012. (DOI: 10.1002/tcr.201200007, PubMed: 22927228) |
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| 16. | Akira Shigenaga, Kohei Sato and Akira Otaka : Recent Progress in the Synthetic Methodologies of Peptide Thioesters, Journal of Synthetic Organic Chemistry, Japan, Vol.68, No.9, 911-919, Sep. 2010. (DOI: 10.5059/yukigoseikyokaishi.68.911, CiNii: 1390001205312881408) |
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| 17. | Akira Shigenaga, Kohei Sato and Akira Otaka : 十字路:セーフティーキャッチリンカー, Journal of Synthetic Organic Chemistry, Japan, Vol.68, No.9, 973, Sep. 2010. (DOI: 10.5059/yukigoseikyokaishi.68.973, CiNii: 1390282680287568896) |
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| 18. | Akira Shigenaga and Akira Otaka : 磁気浮上を利用した簡便な固相反応モニター法の開発, Chemical Biology, Vol.2, 13, May 2009. (Tokushima University Institutional Repository: 116114) |
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| 19. | 大石 真也, 鳴海 哲夫, 大野 浩章, Akira Otaka and 藤井 信孝 : Synthesis of Highly Functionalized Alkene Dipeptide Isosteres and Its Application to the Structure-Activity Relationship Study on Bioactive Peptides, Journal of Synthetic Organic Chemistry, Japan, Vol.66, No.9, 846-857, Sep. 2008. (DOI: 10.5059/yukigoseikyokaishi.66.846, CiNii: 1390282680288398720, Elsevier: Scopus) |
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| 20. | Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka : 刺激応答型アミノ酸を利用した核-細胞質シャトルペプチドの開発, Chemical Biology, Vol.1, No.1, 7-10, May 2008. |
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| 21. | Akira Shigenaga and Akira Otaka : [New type of synthetic peptide library for identifying ligand-binding activity]., Tanpakushitsu Kakusan Koso, Vol.52, No.13 Suppl, 1792-1793, Oct. 2007. (PubMed: 18051429, Elsevier: Scopus) |
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| 22. | 藤井 信孝, 大石 真也 and Akira Otaka : プロテオミクスを基盤とするケミカルバイオロジー -情報から制御へ, Bionics, Vol.3, No.10, 46-51, Oct. 2006. |
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| 23. | Akira Otaka and 藤井 信孝 : 膜融合阻害性抗ウイルスペプチドの開発, Chemical Industry, Vol.57, No.10, 797-801, Oct. 2006. (CiNii: 1523106604538391680) |
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| 24. | 藤井 信孝, Akira Otaka and 玉村 啓和 : ケミカルプロテオミックス先導型創薬基盤の革新, 細胞工学, Vol.15, No.11, 1181-1186, Nov. 2005. |
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| 25. | 西川 裕輝, 藤井 信孝 and Akira Otaka : 抗SARS-CoV活性ペプチドの創製研究, Med. Chem. News, Vol.15, 18-23, 2005. |
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| 26. | Akira Otaka, 藤井 信孝 and 山本 直樹 : SARS治療薬の展望, New Horizon for Medicine, Vol.36, No.11, 64-51, Nov. 2004. |
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| 27. | Akira Otaka, Etsuko Mitsuyama, Junko Watanabe, Hideaki Watanabe and Nobutaka Fujii : Synthesis of fluorine-containing bioisosteres corresponding to phosphoamino acids and dipeptide units, Biopolymers, Vol.76, No.2, 140-149, 2004. (DOI: 10.1002/bip.10570, PubMed: 15054894) |
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| 28. | Akira Otaka : 高付加価値ペプチド合成のための最終脱保護法の開発と細胞内情報伝達機構解明への展開研究, Journal of the Pharmaceutical Society of Japan, Vol.120, 54-67, 2000. |
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| 29. | Akira Otaka and 相本 三郎 : 構造生物学の方法論の新しい展開, Tanpakushitsu Kakusan Koso, Vol.44, 302-309, 1999. |
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| 30. | Akira Otaka and 藤井 信孝 : ジスルフィド結合形成材, 有機合成化学協会誌, Vol.48, 1010-1011, Nov. 1990. |
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| 31. | Akira Otaka and 藤井 信孝 : ペプチド合成における最終脱保護材, 有機合成化学協会誌, Vol.48, 1044-1045, Nov. 1990. |
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| 32. | Akira Otaka and 藤井 信孝 : シスチン含有ペプチドの新規合成法, 有機合成化学協会誌, Vol.48, 658-671, Jul. 1990. |
| 1. | SATOH Daiki, Chiho Shinozaki, Masaya Denda and Akira Otaka : Development of late-stage acylation methodology of threonine residue enabled by chemoselective acyl transfer followed by desulfurization, 37th European Peptide Symposium 14th International Peptide Symposium, Firenze, Aug. 2024. |
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| 2. | Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, Masaya Denda and Akira Otaka : Disulfide-shuffling encountered in insulin synthesis using disulfide-forming reaction enabled by S-protected cysteine and sulfoxide pair, 9th Chemical Protein Synthesis Conference, Nagoya, Jun. 2024. |
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| 3. | JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka : Development of α-thioetherification reaction on peptides for sactipeptide synthesis using glycyl hydroxamic acid, 9th Chemical Protein Synthesis Conference, Nagoya, Jun. 2024. |
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| 4. | SATOH Daiki, Chiho Shinozaki, Masaya Denda and Akira Otaka : Development of acylation protocol of threonine residue by sequential highly efficient acyl transfersdesulfurization, 9th Chemical Protein Synthesis Conference, Nagoya, Jun. 2024. |
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| 5. | Akira Otaka, Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi and Masaya Denda : Insulin Synthesis Using Stepwise Disulfide Bond Formation Enabled by S-Protected Cysteine and Cysteine Sulfoxide Pairs, 9th Chemical Protein Synthesis Conference, Nagoya, Jun. 2024. |
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| 6. | Daishiro Kobayashi, Masaya Denda and Akira Otaka : S-Protected cysteine sulfoxide-enabled peptide and protein customization methodology, Biologics 2024, London, Mar. 2024. |
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| 7. | Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka : DEVELOPMENT OF ONE-POT/STEPWISE DISULFIDE BOND-FORMING REACTION ENABLED BY S-PROTECTED CYSTEINE SULFOXIDE WITH ITS APPLICATION TO SYNTHESIS OF INSULIN AND ITS LIPIDATED ANALOGUE, 13th International Peptide Symposium 15th Australian Peptide Conference, Brisbane, Oct. 2023. |
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| 8. | JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka : DEVELOPMENT OF OXIDANT FREE METHODOLOGY FOR PREPARING N-GLYOXYLYL PEPTIDE AND ITS APPRICATIONS, 13th International Peptide Symposium 15th Australian Peptide Conference, Brisbane, Oct. 2023. |
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| 9. | Daishiro Kobayashi, JUNYA Hayashi, Kohta Hidaka, OHKAWACHI Kento, Yutaka Kohmura, Masaya Denda and Akira Otaka : Protein tryptophan modification enabled by using S-protected cysteine sulfoxide under mild acid conditions, 13th International Peptide Symposium 15th Australian Peptide Conference, Brisbane, Oct. 2023. |
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| 10. | Mika Ohhira, OHKAWACHI Kento, Kaito Anzaki, Mina Hojo, Sayaka Tani, Masaya Denda, Hitoshi Mizuguchi and Akira Otaka : Development of synthetic method for synthesizing di-Tyr-containing bi-aryl peptides enabled by oxidation of sulfenyl Tyr, AIMECS 2023, Seoul, Jun. 2023. |
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| 11. | Chiho Shinozaki, Yutaka Kohmura, Tetsuro Yoshimaru, Tsuyoshi Tahara, Masaya Denda, Hidefumi Mukai, Kohta Mohri, Yi Long Chen, Toyomasa Katagiri and Akira Otaka : Study on a lipidated anti-cancer peptide allowing long-lasting duration in mice model, AIMECS 2023, Seoul, Jun. 2023. |
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| 12. | Akira Otaka, OHKAWACHI Kento, Kaito Anzaki and Masaya Denda : Tyr- or Trp-selective CH sulfenylation enabled by acid- activated S-acetamidomethyl cysteine sulfoxide, 19th Akabori Conference German-Japanese Symposium on Peptide Science, 大津市, May 2023. |
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| 13. | Akira Otaka : Development of Desulfurization-compatible New Thiol Catalyst for Native Chemical Ligation, 18th Akabori Conference German-Japanese Symposium on Peptide Science, Online, Mar. 2021. |
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| 14. | Naoto Naruse, Daishiroh Kobayashi, Akira Shigenaga and Akira Otaka : Copper-mediated Ring Opening of Thiazolidine Derivative for Protein Chemical Synthesis, 27th International Society of Heterocyclic Chemistry Congress, Kyoto, Sep. 2019. |
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| 15. | Naoto Naruse, Daishiroh Kobayashi, Kento Ohkawachi, Akira Shigenaga and Akira Otaka : Development of Novel Ring-Opening Reaction of N-Terminal Thiazolidine for Chemical Protein Synthesis, 26th American Peptide Symposium/11th International Peptide Symposium, Monterey, CA, USA, Jun. 2019. |
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| 16. | Akira Shigenaga, Takuya Morisaki, Taiki Kohiki, Masaya Denda, Tsubasa Inokuma and Akira Otaka : Development of acyl transfer-based chemical biology tools for purification/selective labeling of target proteins, 5th International Symposium for Medicinal Sciences, Chiba, Mar. 2019. |
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| 17. | Taiki Kohiki, Yusuke Kato, Masaya Denda, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka : Development and application of novel protein labeling reagent "SEAL", 10th International Peptide Symposium, Kyoto, Dec. 2018. |
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| 18. | Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, Kenzo Yamatsugu, Akira Shigenaga, Motomu Kanai and Akira Otaka : Development of methodology for cyclic peptide synthesis using a thiol-incorporated DMAP catalyst, 10th International Peptide Symposium, Kyoto, Dec. 2018. |
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| 19. | Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka : Development of anti-cancer peptide based on prohibitin 2, 10th International Peptide Symposium, Kyoto, Dec. 2018. |
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| 20. | Naoto Naruse, Kiyoka Matsumoto, Akira Shigenaga and Akira Otaka : Development of method for deprotection of N-terminal thiazolidine derivative using copper salt for chemical protein synthesis, 10th International Peptide Symposium, Kyoto, Dec. 2018. |
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| 21. | Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : Preparation of protein thioesters enabled by carboxypeptidase-mediated C-terminal specific hydrazinolysis, 10th International Peptide Symposium, Kyoto, Dec. 2018. |
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| 22. | Yusuke Kato, Nobuo Maita, Taiki Kohiki, Sumire Kurosawa, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Kazuko YORITA, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui : Combined approach of computation and enzymology to investigate novel D-amino acid oxidase inhibitors, The 13th International Symposium of the Institute Network for Biomedical Sciences joint with the 3rd Symposium of the Inter-University Research Network for Trans-Omics Medicine and the 28th Hot Spring Harbor Symposium, Fukuoka, Oct. 2018. |
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| 23. | Tsubasa Inokuma, Nishida Kodai, Akira Shigenaga, Ken-ichi Yamada and Akira Otaka : Novel methodology for the synthesis of-indolyl-glycine containing peptidevia direct asymmetric FriedelCrafts reactionto peptidyl imine, 35th European Peptide Symposium, Dublin, Ireland, Aug. 2018. |
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| 24. | Yusuke Kato, Taiki Kohiki, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui : Studies on binding molecules to D-amino acid oxidase using computational approaches, The 12th International Symposium of the Institute Network, Tokyo, Nov. 2017. |
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| 25. | Akira Otaka : Development of anti-breast cancer stapled peptides targeting BIG3-PHB2 interaction, AIMECS 2017, Melbourne, Australia, Jul. 2017. |
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| 26. | Kazuko YORITA, Sumire Kurosawa, Yuri Yoshida, Yoshiki Kashiwada, Shigeki Sano, Akira Otaka and Kiyoshi Fukui : Screening of the effectors for human D-amino acid oxidase and the analyses of structure-activity relationships, The 19th triennial International Symposium on Flavins and Flavoproteins, Groningen, Jul. 2017. |
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| 27. | Akira Otaka : Application of N-Sulfanylethylanilide(SEAlide) Unit to Protein Chemical Synthesis and Protein Enrichment, American Peptide Symposium 2017, Whistler, BC, Canada, Jun. 2017. |
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| 28. | Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : Development of N-Sulfanylethylanilide-based Traceable Linker for Purification and Selective Labeling of Target Proteins, American Peptide Symposium 2017, Whistler, BC, Canada, Jun. 2017. |
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| 29. | Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of methodology for preparation of peptide thioester via on-resin N-S acyl transfer using N-sulfanylethylanilide peptide, American Peptide Symposium 2017, Whistler, BC, Canada, Jun. 2017. |
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| 30. | Akira Otaka, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga and Toyomasa Katagiri : Development of long-lasting stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells, The 6th Pharmaceutical Sciences World Congress 2017, Stockholm, May 2017. |
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| 31. | Koichiro Tsuchiya, Aihara Haruna, Xu Wenting, Jin Meina, Tomida Yosuke, Yamaoka Tomomi, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya : A limonene-derivative from Sudachi peel activates sirt1 and improves lipid and glucose metabolism in high fat diet-fed mice., 欧州糖尿病学会, Dec. 2016. |
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| 32. | Takahiko Hara, Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Naoto Naruse, Kohei Tsuji, Akira Shigenaga and Akira Otaka : A Novel Function of a CXC-type Chemokine CXCL14 as a Specific Carrier of CpG DNA into Dendritic Cells for Activating Toll-like Receptor 9-mediated Adaptive Immunity, 58th ASH Annual Meeting & Exposition, San Diego, Dec. 2016. |
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| 33. | Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma, Kouji Itou and Akira Otaka : Second-Generation Synthetic Strategy of GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library, 34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016. |
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| 34. | Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Intein-inspired Amide Bond Processing Device, 34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016. |
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| 35. | Keisuke Aihara, Kosuke Yamaoka, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : One-Pot/Sequential Native Chemical Ligation Using Photo-responsive Crypto-thioester, 34th European Peptide Symposium 2016 & 8th International Peptide Symposium, Leipzig, Germany, Sep. 2016. |
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| 36. | Akira Otaka, Rin Miyajima, Yusuke Tsuda and Akira Shigenaga : Regioselective S-Cyanylation-mediated Preparation of Peptide Thioester, 16th Akabori Conference Japanese-German Symposium on Peptide Science, Kobe, May 2016. |
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| 37. | Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Kohei Tsuji, Akira Shigenaga, Akira Otaka and Takahiko Hara : A CXC type chemokine CXCL14 directly binds to CpG-C DNA to activate Toll-like receptor 9 signaling, Nucleic Acid Sensing Pathways: Innate Immunity, Immunobiology and Therapeutics (E2), Dresden, May 2016. |
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| 38. | Akira Otaka : N-Sulfanylethylanilide peptide as a crypto thioester for protein chemical synthesis, 5th Modern Solid Phase Peptide Synthesis & Its Application Symposium, Queensland (Australia), Oct. 2015. |
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| 39. | Licht Miyamoto, 粟飯原 遥奈, Wenting Xu, Meina Jin, 冨田 洋介, 山岡 朋美, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya : リモネン誘導体によるsirt1活性化を介した脂質低下作用, 日本肥満学会，アジアオセアニア糖尿病学会, Nagoya, Oct. 2015. |
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| 40. | Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka : Development of Chemistry-based Protocol for Sequence-dependent Thioesterification, American Peptide Symposium 2015, Florida, Jun. 2015. |
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| 41. | Masaya Denda, Takuya Morisaki, Jun Yamamoto, Kohei Sato, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : In Cell Labeling of Target Proteins using ''SEAL-tag'', American Peptide Symposium 2015, Florida, Jun. 2015. |
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| 42. | Licht Miyamoto, Haruna Aihara, Wenting Xu, Meina Jin, Yosuke Tomida, Tomomi Yamaoka, Naonobu Tanaka, Yasumasa Ikeda, Akira Shigenaga, Akira Otaka, Toshiaki Tamaki, Yoshiki Kashiwada and Koichiro Tsuchiya : Limonene-derivative Ameliorates Lipid Profiles by Upregulation of Sirt1 Activity and Expression in Cultured Cells and High Fat Diet-Fed Mice, American diabetes association, Boston, Jun. 2015. |
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| 43. | Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka : Chemical protein synthesis utilizing SEAlide technology that is potentially applicable to incorporation of artificial amino acids into proteins for their functional control, The 2nd International Symposium on Fusion Materials Program, Tokyo, Nov. 2014. |
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| 44. | Akira Otaka, Yusuke Tsuda and Akira Shigenaga : Chemical thioester synthesis applicable to naturally occurring peptide sequence, 15th Akabori Conference Japanese-German Symposium on Peptide Science, Boppard, Sep. 2014. |
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| 45. | Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : Dimerized CXCL14 C-terminal regions inhibit CXCL12-CXCR4 signaling axis, The 33rd European Peptide Symposium, Sofia, Aug. 2014. |
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| 46. | Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : Synthetic study of GM2 activator protein using N-sulfanylethylanilide peptide, The 33rd European Peptide Symposium, Sofia, Aug. 2014. |
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| 47. | Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura, Keisuke Kitakaze, Kouji Itou and Akira Otaka : Development of chemical protocol for preparation of peptide/protein thioesters applicable to naturally occurring sequences, 17th KPPS Annual Symposium, Seoul, Nov. 2013. |
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| 48. | Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : Development of thiol-responsive traceable linker for efficient enrichment and selective labeling of target proteins, 4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013. |
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| 49. | Keisuke Aihara, Akira Shigenaga, Daisuke Takahashi and Akira Otaka : New approach for synthesis of lactam bridged peptides using olefin metathesis on AJIPHASE®, 4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013. |
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| 50. | Miku Kita, Jun Yamamoto, Koji Ebisuno, Chiaki Komiya, Akira Shigenaga, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka : Development of hydrogen peroxide-responsive amide bond cleavage device, 4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013. |
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| 51. | Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura and Akira Otaka : Development of Chemical Protocols for Producing Peptide Thioesters from Naturally Occurring Peptide Sequences, Part 1, 4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013. |
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| 52. | Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Rin Miyajima and Akira Otaka : Development of Chemical Protocols for Producing Peptide Thioesters from Naturally Occurring Peptide Sequences, Part 2, 4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013. |
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| 53. | Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda and Akira Otaka : Application of peptidyl prolyl thioesters to native chemical ligation, 4th Asia-Pacific International Peptide Symposium, 50th Japanese Peptide Symposium, Suita, Nov. 2013. |
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| 54. | Keisuke Aihara, Daisuke Takahashi, Akira Shigenaga and Akira Otaka : Olefin metathesis approach utilizing AJIPHASE(R) for the synthesis of lactam bridged peptides, 4th Modern Solid Phase Peptide Synthesis & Its Application Symposium, Kobe, Nov. 2013. |
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| 55. | Ken Sakamoto, Kohei Sato, Akira Shigenaga and Akira Otaka : Development of practical synthetic method for Fmoc amino acid-incorporated N-sulfanylethyl anilide linker as peptide thioester equivalent, 4th Modern Solid Phase Peptide Synthesis & Its Application Symposium, Kobe, Nov. 2013. |
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| 56. | Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : Application of thiol-responsive amino acid to traceable linker for purification and selective labeling of target protein, 23rd American Peptide Symposium, Hawai'i, Jun. 2013. |
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| 57. | Keisuke Aihara, Kohei Tsuji, Akira Shigenaga and Akira Otaka : Ring-closing metathesis approach for the synthesis of Lys-Glu bridged cyclic peptides, 23rd American Peptide Symposium, Hawai'i, Jun. 2013. |
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| 58. | Ken Sakamoto, Kohei Sato, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : Development of efficient synthetic method for N-amino acyl N-sulfanylethyl anilide linkers as peptide thioester equivalent, 23rd American Peptide Symposium, Hawai'i, Jun. 2013. |
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| 59. | Akira Otaka : Development of "Tracable Linkerfor" Protein Idebtification Using Stimulus-responsive Amino Acid, The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Kyoto, Oct. 2012. |
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| 60. | Masaya Denda, Jun Yamamoto, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : Development of a novel chemical probe that enables selective labeling of proteins, The 1st International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Kyoto, Oct. 2012. |
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| 61. | Akira Otaka, Kohei Sato, Hao Ding and Akira Shigenaga : N-Sulfanylethylanilide peptide for peptide engineering, The Sixth Peptide Engineering Meeting, Atlanta, Oct. 2012. |
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| 62. | Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : Chemical synthesis of human GM2 activator protein analog using SEAlide peptide-mediated one-pot multi-fragment condensation, The 6th Takeda Science Foundation Symposium on PharmaSciences, Suita, Sep. 2012. |
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| 63. | Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Masaya Denda, Hao Ding, Takahiko Hara and Akira Otaka : Development of novel antagonistic peptide for CXCL14 receptor, The 6th Takeda Science Foundation Symposium on PharmaSciences, Suita, Sep. 2012. |
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| 64. | Akira Otaka : Chemical Protein Synthesis Using N-Sulfanylethylanilide Peptide, The 14th Akabori Conference, Niseko, Japan, Sep. 2012. |
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| 65. | Akira Otaka : N-Sulfanylethylanilides as a Versatile Chemical Device for Protein Chemistry, 2012 SNU Symposium on Medicinal Chemistry, Seoul, May 2012. |
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| 66. | Jun Yamamoto, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Akira Shigenaga, Wataru Nomura, Hirokazu Tamamura and Akira Otaka : Application of Stimulus-responsive Amino Acid to Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins, 8th AFMC International Medicinal Chemistry Symposium, Tokyo, Nov. 2011. |
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| 67. | Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Hao Ding, Masaya Denda, Takahiko Hara and Akira Otaka : The First Accomplishment of Development of CXCL14 Antagonistic Peptide by Dimerization of CXCL14 Fragment, 8th AFMC International Medicinal Chemistry Symposium, Tokyo, Nov. 2011. |
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| 68. | Akira Shigenaga, Masaya Denda, Keiji Ogura, Koji Ebisuno and Akira Otaka : Development of caged nonhydrolyzable phosphoserine and its incorporation into biomineralization-related peptide, The 1st International Symposium on Fusion Materials Program, Toba, Oct. 2011. |
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| 69. | Jun Yamamoto, Tomohiro Tanaka, Masaya Denda, Akira Shigenaga, Wataru Nomura, Hirokazu Tamamura and Akira Otaka : Design and synthesis of traceable linker for efficient enrichment and specific labeling of target proteins, 22nd American Peptide Symposium, San Diego, Jun. 2011. |
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| 70. | Kohei Sato, Shugo Tsuda, Kohei Tsuji, Ken Sakamoto, Akira Shigenaga and Akira Otaka : N-sulfanylethylanilide derivative as a peptide thioester equivalent, 22nd American Peptide Symposium, San Diego, Jun. 2011. |
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| 71. | Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol, 22nd American Peptide Symposium, San Diego, Jun. 2011. |
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| 72. | Akira Otaka and Akira Shigenaga : Development of amide bond cleavage device with application to chemical biology use, 5th International Peptide Symposium, Kyoto, Dec. 2010. |
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| 73. | Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : Synthesis and biological evaluation of CXCL14 and its derivatives, 5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010. |
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| 74. | Kohei Sato, Shugo Tsuda, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka : Native chemical ligation using N-peptidyl anilide as crypto-thioester, 5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010. |
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| 75. | Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka : Synthesis of nonhydrolyzable AMPylated amino acid analogues for uncovering the physiological role of AMPylation, 5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010. |
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| 76. | Jun Yamamoto, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka : Development of Recapturable Cleavable Linker for Efficient Enrichment and Specific Labeling of Target Proteins, 5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010. |
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| 77. | Ko Morishita, Keiko Yamaguchi, Hao Ding, Akira Shigenaga, Kenichi Akaji and Akira Otaka : Development of Stimulus Responsive Thiol Releasng System for Controlling Activity of Cysteine Protease, 5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010. |
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| 78. | Akira Shigenaga, Jun Yamamoto, Naomi Nishioka, Masaya Denda and Akira Otaka : Enantioselective synthesis of stimulus-responsive amino acid via pyrrolidinyl tetrazole catalyzed asymmetric -amination of aldehyde, 5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium, Kyoto, Dec. 2010. |
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| 79. | Akira Otaka and Akira Shigenaga : Development of peptide bond cleavage device and its application for chemical biology use, The 13th Akabori Conference, Leipzig, Germany, Sep. 2010. |
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| 80. | Jun Yamamoto, Akira Shigenaga, Yoshitake Sumikawa, Toshiaki Furuta and Akira Otaka : Development of near-infrared two-photon excitation responsive peptide bond cleavage device and examination of its photo-reactivity, 3rd Asia-Pacific International Peptide Symposium, Cheju, Nov. 2009. |
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| 81. | Yoko Yamaki, Akira Shigenaga and Akira Otaka : Synthesis of fluoroalkene dipeptide isosteres utilizing intramolecular redox reaction catalyzed by N-heterocyclic carbene, The 12th Japan-Korea Joint Symposium on Drug Design and Development, Sendai, May 2008. |
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| 82. | Akira Otaka, Akira Shigenaga, Naomi Nishioka, Daisuke Tsuji and Kouji Itou : Cleavage of peptide bonds for the preparation of functional peptides, The 12th Japan-Korea Joint Symposium on Drug Design and Development, Sendai, May 2008. |
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| 83. | Akira Otaka : Amide bond cleavage for the preparation of functional peptides, Roche Colorado Corporation Peptide Symposium, Colorado, USA, Colorado, Sep. 2007. |
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| 84. | Takashi Tsuji, Yoshikazu Sasaki, Keiko Yamaguchi, Akira Shigenaga, Nobutaka Fujii and Akira Otaka : Synthesis of (Z)-alkene cis-Xaa-Pro type dipeptide isosteres using organocopper-mediated anti-SN2' reactions, 43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting, Yokohama, Nov. 2006. |
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| 85. | Akira Shigenaga, Saori Shintaku and Akira Otaka : Development of Photo-responsive Self-processing Peptides, 43rd Japanese Peptide Symposium/4th Peptide Engineering Meeting, Yokohama, Nov. 2006. |
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| 86. | Akira Otaka, Yusuke Ohta, Akira Shigenaga and Nobutaka Fujii : Development of Chemical Devices for Chemical Ligations, The 11th Akabori Conference, Kloster Banz, Germany, Oct. 2006. |
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| 87. | Yoshikazu Sasaki, Takashi Tsuji, Ayumu Niida, Akira Shigenaga, Nobutaka Fujii and Akira Otaka : Regio- and Stereoselective Synthesis of (Z)-Alkene cis-Xaa-Pro Dipeptide Mimetics with Organocopper-mediated Anti-SN2' Reactions, 29th European Peptide Symposium, Gdansk, Sep. 2006. |
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| 88. | Akira Shigenaga, Saori Shintaku and Akira Otaka : Design, Synthesis and Photo-processing Reaction of Peptides Possessing the External Stimulus-responsive Amino Acid, 29th European Peptide Symposium, Gdansk, Sep. 2006. |
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| 89. | Akira Shigenaga, Saori Shintaku and Akira Otaka : Development of Photo-triggered Self-processing Peptides, ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Jul. 2006. |
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| 90. | Yoshikazu Sasaki, Ayumu Niida, Takashi Tsuji, Akira Shigenaga, Nobutaka Fujii and Akira Otaka : Synthesis of (Z)-alkene-containing Pro dipeptide isosteres corresponding to cis-prolyl peptides, The 11th Korea-Japan Joint Symposium On Drug Design and Development, Cheju, May 2006. |
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| 91. | Akira Otaka, Yusuke Ohta, Akira Shigenaga and Nobutaka Fujii : Preparation of peptide thioester utilizing S-protected oxazolidinone derived from systeine, The 11th Korea-Japan Joint Symposium On Drug Design and Development, Cheju, May 2006. |
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| 92. | Akira Otaka : Development of chemal devices for synthesis of proteins including membrane proteins, The 6th International Symposium on Peptide and Protein Materials, Gwangju, Korea, Apr. 2006. |
| 1. | INAZUKI Hayato, Takashi Tsuji, Daishiro Kobayashi, HAYASHI Junya, Masaya Denda and Akira Otaka : Cysteinylprolyl ester を利用した脂肪鎖―薬物複合体からの薬物放出システムの開発研究, 第41回メディシナルケミストリーシンポジウム, Nov. 2024. |
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| 2. | Akira Otaka : 失敗の言語化が未来を拓く, 第63回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2024. |
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| 3. | Akira Otaka : 「失敗の言語化」が拓いたペプチド・タンパク質の修飾反応, 東北大学 第10回 医薬品開発研究センターシンポジウム 次世代創薬に向けたアプローチ, Nov. 2024. |
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| 4. | Akira Otaka : 世界の歴史を変えた化合物たちとペプチド, 日本ペプチド学会 市民フォーラム2024, Nov. 2024. |
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| 5. | Kohta Hidaka, Daishiro Kobayashi, HAYASHI Junya, Masaya Denda and Akira Otaka : SELENAZOLIDINE AS A DUALLY FUNCTIONING AGGREGATION DISRUPTING UNIT, 第61回ペプチド討論会, Oct. 2024. |
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| 6. | NAGATA Tsunaki, Daishiro Kobayashi, Masaya Denda and Akira Otaka : S-保護CysスルホキシドによるTrp選択的スルフェニル化反応を利用したGIP–GLP-1ヘテロダイマー合成, 創薬懇話会2024 札幌, Jun. 2024. |
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| 7. | EGUCHI Aki, OHKAWACHI Kento, Mika Ohhira, Masaya Denda and Akira Otaka : 人工脂質膜を反応場とした難溶性膜タンパク質化学合成法の開発, 創薬懇話会2024 札幌, Jun. 2024. |
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| 8. | OHTA Rika, SATOH Daiki, Masaya Denda and Akira Otaka : 新規スレオニン側鎖アシル化法を用いた刺激応答性機能変換ペプチドの合成, 日本ケミカルバイオロジー学会 第18回年会, May 2024. |
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| 9. | JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka : 主鎖アミド保護基を活用したLossen転位反応による 合成後期ペプチドα位ヘテロ化法の開発, 日本薬学会第144年会, Mar. 2024. |
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| 10. | Akiko Higashiyama, Akito Ohnishi, Shunya Yanagawa, 清良 尚史, W John Regan, OHKAWACHI Kento, Masaya Denda, Keijo Fukushima, 西野 耕平, Akira Otaka, Hidetaka Kosako and Hiromichi Fujino : EP4受容体の細胞内第3ループ領域に相互作用する因子の探索, 日本薬学会第144年会,横浜,2024年3月29日, 2024. |
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| 11. | Chiho Shinozaki, Yutaka Kohmura, Tetsuro Yoshimaru, Masaya Denda, Toyomasa Katagiri and Akira Otaka : 脂肪酸修飾型乳がん増殖抑制ペプチドの開発, 第40回メディシナルケミストリーシンポジウム, Nov. 2023. |
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| 12. | Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka : 脂肪鎖修飾型インスリン誘導体合成を指向したS-保護システインスルホキシドを利用したワンポットジスルフィド形成/脂肪酸修飾法の開発, 第40回メディシナルケミストリーシンポジウム, Nov. 2023. |
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| 13. | Akira Otaka : Side reaction-inspired peptide and protein chemistry, 第60回ペプチド討論会 日本ペプチド学会「学会賞」受賞講演, Nov. 2023. |
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| 14. | Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka : IMPROVEMENT OF INSULIN SYNTHESIS BY COMBINATION OF O-ACYL ISOPEPTIDE METHOD AND ONE-POT/STEPWISE DISULFIDE BOND FORMATION USING S-PROTECTED CYSTEINE SULFOXIDE, 第60回ペプチド討論会, Nov. 2023. |
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| 15. | Mika Ohhira, OHKAWACHI Kento, Kaito Anzaki, Sayaka Tani, Mina Hojo, Masaya Denda, Hitoshi Mizuguchi and Akira Otaka : DEVELOPMENT OF SYNTHETIC METHOD FOR DI-TYR CONTAINING PEPTIDES RELATED TO PARKINSONS DISEASE ENABLED BY OXIDATION SULFENYL TYR, 第60回ペプチド討論会, Nov. 2023. |
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| 16. | Daiki Sato, Chiho Shinozaki, Masaya Denda and Akira Otaka : DEVELOPMENT OF INTERMOLECULAR ACYLATION PROTOCOL OF THREONINE BY A LATE-STAGE SEQUENTIAL ACYL TRANSFER DESULFURIZATION, 第60回ペプチド討論会, Nov. 2023. |
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| 17. | Daishiro Kobayashi, JUNYA Hayashi, Kohta Hidaka, OHKAWACHI Kento, Yutaka Kohmura, Masaya Denda and Akira Otaka : TRYPTOPHAN-SELECTIVE PEPTIDE MODIFICATION USING S-ACETAMIDEMETHYL PROTECTED CYSTEINE SULFOXIDE UNDER MILD ACIDIC CONDITION AND ITS APPLICATION TO PEPTIDE HETERODIMERIZATION, 第60回ペプチド討論会, Nov. 2023. |
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| 18. | JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka : PREPARATION METHODOLOGY OF N-GLYOXYLYL PEPTIDE UTILIZING LOSSEN REARRANGEMENT, 第60回ペプチド討論会, Nov. 2023. |
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| 19. | JUNYA Hayashi, Daishiroh Kobayashi, Masaya Denda and Akira Otaka : Lossen転位を利用したペプチドN末端アルデヒド化法の開発と応用, 第49回反応と合成の進歩シンポジウム, Nov. 2023. |
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| 20. | Daishiroh Kobayashi, JUNYA Hayashi, Kohta Hidaka, Yutaka Kohmura, OHKAWACHI Kento, Masaya Denda and Akira Otaka : Interrupted Pummerer反応によるTrp選択的修飾を利用したOne-potペプチドヘテロ二量化法の開発, 第49回反応と合成の進歩シンポジウム, Nov. 2023. |
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| 21. | OHTA Rika, SATOH Daiki, Masaya Denda and Akira Otaka : 刺激応答性機能変換ペプチドの新規合成法の開発, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023. |
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| 22. | EGUCHI Aki, OHKAWACHI Kento, Mika Ohhira, Masaya Denda and Akira Otaka : 脂質ナノディスクを利用した難溶解性膜タンパク質化学合成法の開発, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023. |
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| 23. | INAZUKI Hayato, Takashi Tsuji, Daishiro Kobayashi, JUNYA Hayashi, Masaya Denda and Akira Otaka : Cysteinyl Prolyl Esterシステムを利用した新規医薬品放出制御システムの開発研究, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023. |
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| 24. | NAGATA Tsunaki, Tomoki Nonaka, Daishiro Kobayashi, Masaya Denda and Akira Otaka : Cys(MBzl)(O)を利用したTrp位置選択的脂肪鎖修飾法の開発と修飾GIP調製への応用, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023. |
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| 25. | Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka : 保護システインスルホキシドを用いたワンポット連続ジスルフィド形成 によるインスリンの合成研究, 創薬懇話会2023 湯河原, Jun. 2023. |
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| 26. | Daiki Satoh, Chiho Shinozaki, Masaya Denda and Akira Otaka : ユビキチン化の機能解明を志向した新規スレオニン側鎖アシル化法の開発, 日本ケミカルバイオロジー学会 第17回年会, May 2023. |
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| 27. | Masaya Denda, Tomoki Nonaka, Daishiro Kobayashi, JUNYA Hayashi, Yasuda Takuma, Yutaka Kohmura, Harada Norio, Inagaki Nobuya and Akira Otaka : S-保護システインスルホキシドを利用したトリプトファン選択的修飾法の開発, 日本ケミカルバイオロジー学会 第17回年会, May 2023. |
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| 28. | OHKAWACHI Kento, Kaito Anzaki, Daishiro Kobayashi, 喜屋武 龍二, Masaya Denda, Akira Shigenaga and Akira Otaka : S-保護システインスルホキシドを利用した残基選択的C-Hスルフェニル化反応の開発, 日本薬学会第143年会, Mar. 2023. |
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| 29. | Daiki Satoh, Chiho Shinozaki, Masaya Denda and Akira Otaka : 連続アシル転移を利用した分子内および分子間スレオニン側鎖アシル化法の開発, 日本薬学会第143年会, Mar. 2023. |
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| 30. | Kohki Fukuhara, Tsubasa Inokuma, MASUI Kana, Masaya Denda, Akira Otaka and Ken-ichi Yamada : N-2-Nitrophenylsulfenylイミノペプチドへのジアステレオ選択的インドリル化反応の開発, 日本薬学会第143年会, Mar. 2023. |
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| 31. | JUNYA Hayashi, Daishiroh Kobayashi, Masaya Denda and Akira Otaka : アシルイミニウムカチオンを経由したペプチド主鎖修飾反応の開発, 第48回反応と合成の進歩シンポジウム, Nov. 2022. |
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| 32. | Tomoki Nonaka, Daishiro Kobayashi, KURAOKA Eisuke, JUNYA Hayashi, Yasuda Takuma, Yutaka Kohmura, Masaya Denda, Harada Norio, Inagaki Nobuya and Akira Otaka : S-保護システインスルホキシドを利用したトリプトファン選択的脂肪鎖修飾法の開発と応用, 第39回メディシナルケミストリーシンポジウム, Nov. 2022. |
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| 33. | Mika Ohhira, OHKAWACHI Kento, Kaito Anzaki, Mina Hohjoh, Hitoshi Mizuguchi, Masaya Denda and Akira Otaka : スルフェニル化Tyrを利用したTyr-Tyrビアリール構造含有ペプチド合成法の開発, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022. |
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| 34. | Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka : S-保護システインスルホキシドを利用したトリプトファン選択的修飾反応の開発とペプチドヘテロ二量化法への応用展開, 第61回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2022. |
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| 35. | Tsubasa Inokuma, MASUI Kana, Masaya Denda, Akira Otaka and Ken-ichi Yamada : Diastereoselective indolylation of N-2-nitrophenylsulfenyl iminopeptide for the synthesis of α-indolylglycine-containing peptide, 第59回ペプチド討論会, Oct. 2022. |
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| 36. | Kohta Hidaka, Daishiro Kobayashi, JUNYA Hayashi, OHKAWACHI Kento, Masaya Denda and Akira Otaka : DEVELOPMENT OF ONE-POT/STEPWISE DISULFIDE BOND-FORMING REACTION ENABLED BY S-PROTECTED CYSTEINE SULFOXIDE WITH ITS APPLICATION TO INSULIN SYNTHESIS, 第59回ペプチド討論会, Oct. 2022. |
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| 37. | JUNYA Hayashi, Daishiro Kobayashi, Masaya Denda and Akira Otaka : DEVELOPMENT OF INTRAMOLECULAR THIOETHERIFICATION ON PEPTIDE BACKBONE FOR CHEMICAL SYNTHESIS OF SACTIPEPTIDE, 第59回ペプチド討論会, Oct. 2022. |
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| 38. | JUNYA Hayashi, Daishiroh Kobayashi, Masaya Denda and Akira Otaka : ペプチド主鎖修飾反応の開発とチオエーテル含有環状ペプチド合成への展開, 第54回若手ペプチド夏の勉強会, Aug. 2022. |
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| 39. | Daishiroh Kobayashi, JUNYA Hayashi, Kohta Hidaka, OHKAWACHI Kento, Yutaka Kohmura, Masaya Denda and Akira Otaka : 保護システインスルホキシドを利用したペプチド・タンパク質Trp残基選択的修飾法の開発研究, 第54回若手ペプチド夏の勉強会, Aug. 2022. |
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| 40. | JUNYA Hayashi, Daishiroh Kobayashi, Masaya Denda and Akira Otaka : Lossen転位を起点とした合成後期ペプチド主鎖ヘテロ化反応の開発, 創薬懇話会2022 in 名古屋, Jul. 2022. |
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| 41. | Daishiroh Kobayashi, KURAOKA Eisuke, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka : S-保護システインスルホキシドを利用したトリプトファン選択的修飾反応の開発研究, 日本薬学会第142年会, Mar. 2022. |
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| 42. | Yutaka Kohmura, Daishiroh Kobayashi, Masaya Denda and Akira Otaka : MBzl保護システインスルホキシドの芳香族化合物に対する反応性評価とペプチド架橋法への応用展開, 日本薬学会第142年会, Mar. 2022. |
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| 43. | SATOH Daiki, Honoka Tsunematsu, Isamu Konishi, UEDA Tomoko, Chiaki Komiya, Masaya Denda, Akira Shigenaga and Akira Otaka : 側鎖無保護ペプチドへの適用可能な合成後期ラクトン化法の開発, 日本薬学会第142年会, Mar. 2022. |
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| 44. | Akito Ohnishi, Akiko Higashiyama, Shunya Yanagawa, 清良 尚史, W John Regan, Kento Ohkawachi, Masaya Denda, Keijo Fukushima, Akira Otaka and Hiromichi Fujino : プロスタノイドEP4受容体の1アミノ酸変異によるシグナル伝達プロファイル変化, 第95回日本薬理学会年会，福岡, Mar. 2022. |
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| 45. | MASUI Kana, Takuya Sakakibara, Tsubasa Inokuma, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : キラルN-Npsイミノペプチドへのインドールのジアステレオ選択的付加, 第60回日本薬学会中国四国支部学術大会, Oct. 2021. |
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| 46. | Kaito Anzaki, OHKAWACHI Kento, Daishiroh Kobayashi, 喜屋武 龍二, Masaya Denda, Akira Shigenaga and Akira Otaka : RESIDUE-SPECIFIC MODIFICATION REACTION USING S-ACETAMIDOMETHYL CYSTEINE SULFOXIDE, Cys(Acm)(O), 第58回ペプチド討論会, Oct. 2021. |
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| 47. | Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka : Development of copper and iron-mediated Cys-Trp-linking reaction, 第58回ペプチド討論会, Oct. 2021. |
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| 48. | Daishiroh Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda and Akira Otaka : 銅添加を鍵としたシステイン-トリプトファン間架橋反応の開発研究, 第53回若手ペプチド夏の勉強会, Aug. 2021. |
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| 49. | Tomoki Nonaka, Kento Ohkawachi, Masaya Denda and Akira Otaka : Sulfanylmethyl DMAPを利用した環状ペプチド合成に関する研究, 第53回若手ペプチド夏の勉強会, Aug. 2021. |
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| 50. | Kaito Anzaki, Kento Ohkawachi, Daishiroh Kobayashi, 喜屋武 龍二, Masaya Denda, Akira Shigenaga and Akira Otaka : Acm 保護 Cys スルホキシドを利用した化学選択的 S-Aryl 化反応開発研究, 第53回若手ペプチド夏の勉強会, Aug. 2021. |
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| 51. | Kaito Anzaki, Kento Ohkawachi, Daishiroh Kobayashi, 喜屋武 龍二, Masaya Denda, Akira Shigenaga and Akira Otaka : 保護Cysスルホキシドを利用したS–Aryl化環状ペプチド合成研究, 創薬懇話会2021 in 京都, Jun. 2021. |
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| 52. | Yutaka Kohmura, Daishiroh Kobayashi, 杉木 俊彦, Tetsuro Yoshimaru, Eisuke Kuraoka, Masaya Denda, 藤原 敏道, Toyomasa Katagiri and Akira Otaka : Cys-Trp 架橋型乳がん抑制ペプチド(ERAP)の合成及び活性評価, 創薬懇話会2021 in 京都, Jun. 2021. |
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| 53. | Masaya Denda, Chiaki Komiya, Masahiro Ueda, Jun Tsukimoto, Kouji Itou, Akira Shigenaga and Akira Otaka : 既存モダリティの高度化を指向したペプチド・タンパク質新規修飾法の開発, 日本薬剤学会第36年会, May 2021. |
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| 54. | Sayuki Arii, Masahiro Ueda, Akira Shigenaga, Akira Otaka, Tsubasa Inokuma, Ken-ichi Yamada, Tatsuhiro Ishida and Keiichiro Okuhira : 新規タンパク分解誘導剤によるチミジル酸合成酵素阻害メカニズムの解明, 日本薬剤学会第36年会, May 2021. |
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| 55. | SATOH Daiki, Honoka Tsunematsu, UEDA Tomoko, Chiaki Komiya, Masaya Denda, Akira Shigenaga and Akira Otaka : 側鎖無保護ペプチドを用いた環状デプシペプチド簡便合成法の開発, 日本薬学会第141年会, Mar. 2021. |
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| 56. | Daishiroh Kobayashi, Yutaka Kohmura, KURAOKA Eisuke, Masaya Denda and Akira Otaka : S-保護システインスルホキシドを利用したCys-Trpチオエーテル結合形成反応の開発, 日本薬学会第141年会, Mar. 2021. |
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| 57. | Daiki Satoh, Honoka Tsunematsu, Tomoko Ueda, Chiaki Komiya, Masaya Denda, Akira Shigenaga and Akira Otaka : Development of a protection-free protocol for the synthesis of lactone peptides, 第57回ペプチド討論会, Nov. 2020. |
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| 58. | Daishiroh Kobayashi, Naoto Naruse, Masaya Denda, Akira Shigenaga and Akira Otaka : Deprotection of S-acetamidomethyl cysteine mediated by copper salts, 第57回ペプチド討論会, Nov. 2020. |
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| 59. | Kento Ohkawachi, Daishiroh Kobayashi, Kyohei Morimoto, Akira Shigenaga, Masaya Denda, Kenzo Yamatsugu, Motomu Kanai and Akira Otaka : A new thiol additive for one-pot sequential peptide ligation-desulfurization chemistry, 第57回ペプチド討論会, Nov. 2020. |
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| 60. | Tsubasa Inokuma, Masui Kana, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : Development of asymmetric addition of indole nucleophile to imino peptide, 第49回複素環化学討論会, Sep. 2020. |
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| 61. | Atsushi Kanayama, Kento Ohkawachi, Taro Shimizu, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira : 人工HDLの化学的性状と抗腫瘍効果への影響に関する検討, 日本薬学会第140年会, Mar. 2020. |
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| 62. | Honoka Tsunematsu, Tomoko Ueda, Daiki Satoh, Chiaki Komiya, Akira Shigenaga and Akira Otaka : S-Oアシル転移を基盤とする環状デプシペプチドの合成, 日本薬学会第140年会, Mar. 2020. |
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| 63. | Takuya Sakakibara, Tsubasa Inokuma, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : 安定なα-イミノリン酸エステルの開発とキラルα-アミノリン酸の触媒的不斉合成への応用, 日本薬学会第140年会, Mar. 2020. |
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| 64. | Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Yusuke Nishikawa, Masato Komatsu, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka : 乳がん細胞におけるBIG3-PHB2相互作用を標的とした高持続性架橋ペプチドの開発, 日本薬学会第140年会, Mar. 2020. |
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| 65. | Manabu Sugiyama, Akito Ohnishi, Takuya Morisaki, Akira Shigenaga, Keijo Fukushima, Akira Otaka and Hiromichi Fujino : inteinシステムを用いたプロスタノイドEP4受容体の局在解析を目指して, 日本薬学会第140年会, Mar. 2020. |
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| 66. | Akira Otaka : 人工タンパク質創製のためのタンパク質チオエステル調製法の開発, 日本プロセス化学会2019ウィンターシンポジウム, Dec. 2019. |
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| 67. | Tsubasa Inokuma, Kohdai Nishida, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : Chiral Phosphoric Acid-Catalyzed Asymmetric Mannich-Type Reaction Using Imino Peptide as Substrate, 第12回 有機触媒シンポジウム, Dec. 2019. |
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| 68. | 種子島 幸祐, 三井 貴洋, 岩瀬 璃奈, Naoto Naruse, Akira Shigenaga, Akira Otaka and 原 孝彦 : CpG DNAと CXCL14による自然免疫系の協調的な調節メカニズム, 第42回日本分子生物学会年会, Dec. 2019. |
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| 69. | 中川 美帆, 種子島 幸祐, 三井 貴洋, Naoto Naruse, Akira Shigenaga, Akira Otaka, 佐久間 啓 and 原 孝彦 : ケモカイン CXCL14の脳内ミクログリアに対する働き, 第42回日本分子生物学会年会, Dec. 2019. |
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| 70. | Sayuki Arii, Masahiro Ueda, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira : プロテインノックダウン法を用いたチミジル酸合成酵素分解誘導剤開発, 第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2019. |
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| 71. | Takuya Sakakibara, Tsubasa Inokuma, Kana Masui, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : 安定なα-イミノリン酸エステルへの触媒的不斉付加を用いるキラルα-アミノリン酸の合成, 第45回反応と合成の進歩シンポジウム, Oct. 2019. |
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| 72. | Daishiroh Kobayashi, Naoto Naruse, Akira Shigenaga and Akira Otaka : 銅塩を利用するシステインS-保護基除去反応の開発, 第45回反応と合成の進歩シンポジウム, Oct. 2019. |
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| 73. | Tsubasa Inokuma, Kana Masui, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : Development of the direct asymmetric indolylation of imino peptide for synthesis of indolylglycine-containing peptide, 第56回ペプチド討論会, Oct. 2019. |
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| 74. | Daishiroh Kobayashi, Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Lossen rearrangement-mediated preparation of N-glyoxylyl peptide without addition of oxidant, 第56回ペプチド討論会, Oct. 2019. |
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| 75. | 浜田 麻衣, Atsushi Nakayama, 中山 慎一朗, Jumpei Teramachi, Daisuke Tsuji, Akira Shigenaga, 安部 正博, Kouji Itou, Akira Otaka and Kosuke Namba : 天然マクロライドの網羅的全合成が拓く新規多発性骨髄腫治療薬の開発研究, 2019年度第2回(第30回)日本プロセス化学会東四国フォーラムセミナー, Oct. 2019. |
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| 76. | Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, 山次 健三, Akira Shigenaga, 金井 求 and Akira Otaka : チオール導入型DMAP触媒を利用した環状ペプチド合成法の開発, 第51回若手ペプチド夏の勉強会, Aug. 2019. |
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| 77. | 浜田 麻衣, 森崎 巧也, Atsushi Nakayama, Jumpei Teramachi, Daisuke Tsuji, Akira Shigenaga, Takenori Yamamoto, Yasuo Shinohara, Akira Otaka, Kouji Itou, 安部 正博 and Kosuke Namba : 天然マクロライドの全合成が拓く新規多発性骨髄腫治療薬, 創薬懇話会2019 in 秋保(仙台), Jun. 2019. |
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| 78. | Daishiroh Kobayashi, Naoto Naruse, Akira Shigenaga and Akira Otaka : 銅塩を基点とする，タンパク合成を指向した反応開発研究, 創薬懇話会2019 in 秋保, Jun. 2019. |
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| 79. | Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka : がん抑制因子PHB2の部分配列を基盤とした乳がん阻害ペプチドの開発, 創薬懇話会2019 in 秋保, Jun. 2019. |
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| 80. | Akira Otaka : 天然に学ぶタンパク質化学とタンパク・ペプチド性医薬品の可能性, 神戸ポートアイランド創薬フォーラム, Jun. 2019. |
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| 81. | Tsubasa Inokuma, Kana Masui, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : Development of Novel Methodology for the Synthesis of Non-Proteinogenic Amino Acid-Containing Peptide via Direct Asymmetric Reaction to Peptidyl Substrate, 日本ケミカルバイオロジー学会第14回年会, Jun. 2019. |
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| 82. | Atsushi Kanayama, Kento Ohkawachi, Taro Shimizu, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira : 腫瘍DDSキャリアとしての人工HDLの調製および動態の評価, 日本薬剤学会第34年会, May 2019. |
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| 83. | Naoto Naruse, Akira Shigenaga and Akira Otaka : タンパク質合成を指向したチアゾリジン誘導体の脱保護法の開発, 日本薬学会第139年会, Mar. 2019. |
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| 84. | Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka : がん抑制タンパク質PHB2を基盤とした新規創薬シーズの開発, 日本薬学会第139年会, Mar. 2019. |
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| 85. | Mai Hamada, Atsushi Nakayama, Akira Shigenaga, Daisuke Tsuji, Jumpei Teramachi, 安部 正博, Kouji Itou, Akira Otaka and Kosuke Namba : 新規Ynone化合物の創生・評価, 日本薬学会第139年会, Mar. 2019. |
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| 86. | Tsubasa Inokuma, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : Synthesis of indolyl glycine-containing peptide via direct asymmetric reaction to peptide, 日本薬学会第139年会, Mar. 2019. |
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| 87. | 三井 貴洋, 種子島 幸祐, Naoto Naruse, Akira Shigenaga, Akira Otaka and 原 孝彦 : CpG DNA/CXCL14複合体に対する候補受容体の発現クローニング, 第41回日本分子生物学会年会, Nov. 2018. |
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| 88. | 岩瀬 璃奈, Naoto Naruse, 種子島 幸祐, Akira Shigenaga, Akira Otaka and 原 孝彦 : CXCL14とCpG DNAの相互作用によるTLR9活性化の特異性と責任領域の解析, 第41回日本分子生物学会年会, Nov. 2018. |
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| 89. | Sakakibara Takuya, Tsubasa Inokuma, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : 非天然側鎖構造を有するα-アミノリン酸の実用的不斉合成, 第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018. |
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| 90. | Takuya Morisaki, Akira Shigenaga and Akira Otaka : SECmideを基盤としたターンオン型蛍光クリーバブルリンカーの開発, 第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018. |
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| 91. | Masahiro Ueda, Chiaki Komiya, Akira Shigenaga and Akira Otaka : 酵素を利用したチオエステル化反応の効率化を指向したペプチドC末配列の修飾, 第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018. |
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| 92. | Atsushi Kanayama, Keiichiro Okuhira, Kento Ohkawachi, Taro Shimizu, Akira Shigenaga, Akira Otaka and Tatsuhiro Ishida : 人工HDLの化学的性状と体内動態への影響に関する検討, 第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2018. |
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| 93. | Tsubasa Inokuma, Kazuki Okada, Kohdai Nishida, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : ペプチドイミンに対する不斉1,2-付加を基盤とする非天然アミノ酸含有ペプチドの不斉合成, 第44回反応と合成の進歩シンポジウム, Nov. 2018. |
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| 94. | Akira Otaka : 自然に学ぶタンパク質化学, ペプチド研究所 フィッシャー祭, Oct. 2018. |
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| 95. | 中西 雅之, Taiki Kohiki, Akira Shigenaga, Akira Otaka, 田中 信忠, 北出 幸夫, 日野 真美 and 野元 裕 : S-アデノシルホモシステイン加水分解酵素の蛍光性基質の開発, 第91回日本生化学会大会, Sep. 2018. |
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| 96. | Masahiro Ueda, Chiaki Komiya, Akira Shigenaga and Akira Otaka : 酵素を利用したチオエステル調製 のためのC末ペプチド配列の最適化, 第50回若手ペプチド夏の勉強会, Aug. 2018. |
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| 97. | Keitaroh Anyohji, Keisuke Aihara, Tetsuro Yoshimaru, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka : がん 抑制タンパク質PHB2からの創薬シード発掘, 第50回若手ペプチド夏の勉強会, Aug. 2018. |
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| 98. | Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : N-Sアシル基転移速度 の向上を指向した新規補助基の開発, 第50回若手ペプチド夏の勉強会, Aug. 2018. |
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| 99. | Kento Ohkawachi, Kyohei Morimoto, Naoto Naruse, Akira Shigenaga, 金井 求 and Akira Otaka : 新規チオ ール触媒を利用した分子内ライゲーション法の開発, 第50回若手ペプチド夏の勉強会, Aug. 2018. |
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| 100. | Takuya Morisaki, Atsushi Nakayama, Kosuke Namba, Akira Shigenaga and Akira Otaka : トレーサブルリンカー を用いた共有結合性低分子の標的同定, 第50回若手ペプチド夏の勉強会, Aug. 2018. |
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| 101. | Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : On-resinチオエス テル化法から得られた知見とその応用, 第50回若手ペプチド夏の勉強会, Aug. 2018. |
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| 102. | Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : 加水分解酵素を利用したC末端特異的チオエステル化反応の開発, 第50回若手ペプチド夏の勉強会, Aug. 2018. |
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| 103. | Takuya Sakakibara, Tsubasa Inokuma, Akira Shigenaga, Akira Otaka and Ken-ichi Yamada : 安定なイミンを用いたα-アミノリン酸の実用的不斉合成, 創薬懇話会 2018 in 志賀島, Jun. 2018. |
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| 104. | Kento Ohkawachi, Naoto Naruse, Akira Shigenaga and Akira Otaka : 新規チオール触媒を利用した環状ペプチド合成法の開発, 創薬懇話会 2018 in 志賀島, Jun. 2018. |
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| 105. | Chiaki Komiya, Jun Tsukimoto, Masahiro Ueda, Takuya Morisaki, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : 発現タンパク質に適用可能な新規チオエステル合成法の開発, 創薬懇話会 2018 in 志賀島, Jun. 2018. |
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| 106. | Naoki Miyashita, Keiichiro Okuhira, Haruka Kawahara, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and Tatsuhiro Ishida : 動脈硬化治療を指向した光制御型HDL構成ペプチドの開発, 日本薬剤学会第33年会, Jun. 2018. |
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| 107. | Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : 均一修飾タンパク質の合成を指向したタンパク質C末端特異的活性化反応の開発, 日本薬学会第138年会, Mar. 2018. |
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| 108. | Akira Shigenaga and Akira Otaka : アシル基転移反応を基盤とする標的タンパク質精製・機能解明ツールの開発, 日本薬学会第138年会(シンポジウム 中分子創薬研究のフロンティア), Mar. 2018. |
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| 109. | Akira Otaka : タンパク質加水分解酵素を利用したタンパク質C末端特異的チオエステル化反応の開発, ペプチド科学談話会2018, Mar. 2018. |
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| 110. | Akira Otaka : 脱不斉化ヘリックスペプチドはPPI 制御分子として機能するか?, 第1回 徳島大学統合的がん創薬研究クラスター合同ミーティング, Feb. 2018. |
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| 111. | Yusuke Kato, Taiki Kohiki, Yusuke Nishikawa, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Yuji Shishido, Akira Shigenaga, Akira Otaka and Kiyoshi Fukui : DAO分子表面に結合する阻害分子の計算科学的解析, 2017年度生命科学系学会合同年次大会, Dec. 2017. |
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| 112. | Naoto Naruse, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : N-S-acyl-transfer-mediated On-resin Formation of Thioester with Practical Application to Peptide Synthesis, 第54回ペプチド討論会, Nov. 2017. |
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| 113. | Chiaki Komiya, Jun Tsukimoto, Takuya Morisaki, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga, Kouji Itou and Akira Otaka : Development of methodology for producing thioesters from naturally occurring peptide sequence, 第54回ペプチド討論会, Nov. 2017. |
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| 114. | Chiharu Mizuguchi, 伊藤 恵理子, Mitsuki Nakamura, 扇田 隆司, 馬場 照彦, Akira Shigenaga, 島内 寿德, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : 脂質膜組成によるIowa変異型アポA-Iの線維化制御メカニズムの解明, 膜シンポジウム2017, Nov. 2017. |
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| 115. | Akira Otaka : 有機化学メジャーの薬剤師・創薬科学研究者を育成しよう, 第12回有機化学系教科担当教員会議, Nov. 2017. |
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| 116. | Chiaki Komiya, Yusuke Tsuda, Rin Miyajima, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : タンパク質C末端特異的活性化反応の開発, 第35回メディシナルケミストリーシンポジウム, Oct. 2017. |
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| 117. | Takahisa Jichu, Keisuke Aihara, Kohsuke Yamaoka, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : チオエステル等価体ユニットを利用した環状ペプチド効率的合成法の開発, 第35回メディシナルケミストリーシンポジウム, Oct. 2017. |
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| 118. | Akira Otaka : モルフィネからはじまる薬の話, 第56回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会:高校生向けランチョンセミナー, Oct. 2017. |
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| 119. | Mana Yoshino, Licht Miyamoto, Tomomi Yamaoka, Mayu Hosoi, Takuya Morisaki, Keitaroh Anyohji, Akira Shigenaga, Akira Otaka and Koichiro Tsuchiya : 骨格筋培養細胞でのレプチン作用におけるSIRT1の役割, 第56回 中国四国支部学術大会, Oct. 2017. |
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| 120. | Kento Ohkawachi, Naoto Naruse, Akira Shigenaga and Akira Otaka : On-resinチオエステル化を利用した環状ペプチド合成法の開発, 第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Oct. 2017. |
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| 121. | Taiki Kohiki, Yusuke Kato, Yusuke Nishikawa, Kazuko YORITA, Ikuko Sagawa, Masaya Denda, Tsubasa Inokuma, Akira Shigenaga, Kiyoshi Fukui and Akira Otaka : N-Sアシル基転移を基盤としたタンパク質ラベル化法を用いたD-アミノ酸酸化酵素阻害剤の結合サイト解明研究, 第56回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Oct. 2017. |
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| 122. | 小久保 友絵, 池田 茉莉那, 渡部 匡史, Akira Shigenaga, Akira Otaka and 藤室 雅弘 : 徳島大学化合物ライブラリーを用いた抗ヘルペスウイルス化合物の探索, 第67回日本薬学会近畿支部大会, Oct. 2017. |
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| 123. | Akira Otaka : 薬学基礎教育と臨床教育連携への提言-薬学における教養 化学-, 第2回日本薬学教育学会大会, Sep. 2017. |
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| 124. | Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : タンパク質位置選択的修飾を目指したチオエステル調製法の開発, 第49回若手ペプチド夏の勉強会, Aug. 2017. |
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| 125. | Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : ペプチドへの直接的不斉反応を基盤とする非天然アミノ酸含有ペプチドの新規効率的合成法の開発, 第49回若手ペプチド夏の勉強会, Aug. 2017. |
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| 126. | Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : N-Sアシル基転移反応の速度差を利用したライゲーション反応のための新規補助基の開発, 第49回若手ペプチド夏の勉強会, Aug. 2017. |
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| 127. | Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : ペプチド創薬を指向した非天然アミノ酸含有ペプチドの新規効率的合成法の開発, 創薬懇話会2017 in 加賀, Jul. 2017. |
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| 128. | Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : タンパク質化学合成のための新規N-ペプチジルアニリド型補助基の開発, 創薬懇話会2017 in 加賀, Jul. 2017. |
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| 129. | Haruka Kawahara, Keiichiro Okuhira, Naoki Miyashita, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and Tatsuhiro Ishida : 光応答性アポリポタンパク質の開発, 日本薬剤学会第32年会, May 2017. |
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| 130. | Tsubasa Inokuma, Nishida Koudai, Akira Shigenaga and Akira Otaka : ペプチドへの直接的不斉反応を基盤とする新規非天然アミノ酸含有ペプチド合成テクノロジーの開発, 日本薬学会第137年会, Mar. 2017. |
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| 131. | Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, 内村 健治, 加藤 くみ子, Akira Shigenaga, 川上 徹, Akira Otaka, 北條 裕信, Naomi Sakashita and Hiroyuki Saito : アルギニンペプチドのグリコサミノグリカン糖鎖を介した細胞膜透過機構に関する物理化学的解析, 日本薬学会第137年会, Mar. 2017. |
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| 132. | Kohdai Nishida, Takahisa Jichu, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : MnO2を用いたα-イミノカルボン酸誘導体の効率的合成法の開発, 日本薬学会第137年会, Mar. 2017. |
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| 133. | Takara Kawano, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : チオエステル等価体として機能するタンパク質の化学合成のための新規補助基の開発, 日本薬学会第137年会, Mar. 2017. |
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| 134. | Taiki Kohiki, Masaya Denda, 藤川 昴樹, Tsubasa Inokuma, Akira Shigenaga, Kentaro Kogure and Akira Otaka : N-Sulfanylethylanilideを用いた細胞内標的タンパク質ラベル化法の開発, 日本薬学会第137年会, Mar. 2017. |
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| 135. | Kyohei Morimoto, 山次 建三, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga, 金井 求 and Akira Otaka : DMAP誘導体を用いた環状ペプチド合成法の開発, 日本薬学会第137年会, Mar. 2017. |
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| 136. | Naoto Naruse, 津田 修吾, Kento Ohkawachi, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 効率的タンパク質合成のためのSEAlideペプチドを用いたon-resinチオエステル化法の開発, 日本薬学会第137年会, Mar. 2017. |
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| 137. | 種子島 幸祐, 高橋 伶奈, 塗谷 秀子, Naoto Naruse, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and 原 孝彦 : CXCケモカインCXCL14はCpG DNAに結合し，Toll-like receptor 9シグナルを活性化する, 第39回日本分子生物学会年会, Dec. 2016. |
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| 138. | Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka : タンパク質位置選択的修飾を指向したチオエステル調製法の開発, 第34回メディシナルケミストリーシンポジウム, Dec. 2016. |
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| 139. | Naoto Naruse, 種子島 幸祐, Kouhei Tsuji, Tsubasa Inokuma, Akira Shigenaga, 原 孝彦 and Akira Otaka : N-Sulfanylethylanilideペプチドを利用したケモカイン誘導体の合成とToll-like receptor 9の活性化への影響について, 第34回メディシナルケミストリーシンポジウム, Dec. 2016. |
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| 140. | Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : SEAlideを基盤とした標的タンパク質精製ツールの開発研究, 第34回メディシナルケミストリーシンポジウム, Dec. 2016. |
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| 141. | 伊藤 幸裕, Keisuke Aihara, Paolo Mellini, 東條 敏史, 太田 庸介, 津元 裕樹, Viswas Raja Solomon, Peng Zhan, 鈴木 美紀, 小笠原 大介, Akira Shigenaga, Tsubasa Inokuma, 中川 秀彦, 宮田 直樹, 水上 民夫, Akira Otaka and 鈴木 孝禎 : ヒドラジン構造を持つペプチド性LSD1阻害薬の創製, 第34回メディシナルケミストリーシンポジウム, Dec. 2016. |
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| 142. | Chiharu Mizuguchi, Shiho Mikawa, 馬場 照彦, 島内 寿徳, Akira Shigenaga, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : アミロイドーシス変異アポA-I Iowaの脂質膜結合状態の解析, 膜シンポジウム2016, Dec. 2016. |
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| 143. | Naoto Naruse, Mitsuhiro Etoh, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : N-Sulfanylethylcoumarinylamide (SECmide) を利用したN-Sアシル転移促進剤の探 索とペプチド合成への応用, 第42回反応と合成の進歩シンポジウム, Nov. 2016. |
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| 144. | Kohdai Nishida, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 非天然アミノ酸含有ペプチドの新規効率的合成法の開発, 第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Nov. 2016. |
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| 145. | Naoto Naruse, Kouhei Satou, Takahiro Nakamura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : マンノース6リン酸修飾型GM2活性化タンパク質の合成研究, 第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Nov. 2016. |
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| 146. | Keisuke Aihara, Takahisa Jichu, Kohsuke Yamaoka, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : ケミカルバイオロジー研究を指向した環状ペプチドtrichamideの合成研究, 第55回日本薬学会・日本薬剤師会・日本大学病院薬剤師会中国四国支部学術大会, Nov. 2016. |
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| 147. | Chiemi Sato, Shinji Abe, Naoto Okada, Tatsuhiro Ishida, Koichiro Tsuchiya, Akira Otaka and Kazuyoshi Kawazoe : 地域薬局における災害対策の現状と課題, 第55回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2016. |
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| 148. | Ryo Nadai, Yuki Haraya, Kazuchika Nishitsuji, 内村 健治, 加藤 くみ子, Akira Shigenaga, 川上 徹, Akira Otaka, Akira Otaka, 北條 裕信, Naomi Sakashita and Hiroyuki Saito : Sulfated glycosaminoglycans promote cell membrane penetration of arginine peptides via enthalpy-driven interactions, 第53回ペプチド討論会, Oct. 2016. |
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| 149. | Shiho Mikawa, Chiharu Mizuguchi, Izumi Morita, 大山 浩之, 馬場 照彦, Akira Shigenaga, 島内 寿徳, 小林 典裕, Akira Otaka and Hiroyuki Saito : Effect of heparin on amyloid fibril formation of apoA-I fragment peptides, 第53回ペプチド討論会, Oct. 2016. |
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| 150. | 伊藤 幸裕, Keisuke Aihara, Paolo Mellini, 東條 敏史, 太田 庸介, 津元 裕樹, Viswas Raja Solomon, Peng Zhan, 鈴木 美紀, 小笠原 大介, Akira Shigenaga, Tsubasa Inokuma, 中川 秀彦, 宮田 直樹, 水上 民夫, Akira Otaka and 鈴木 孝禎 : Design, synthesis and biological evaluation of SNAIL1 peptide-based lysine specific demethylase 1 inhibitors, 第53回ペプチド討論会, Oct. 2016. |
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| 151. | Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : One-pot sequential native chemical ligations using photocaged crypto-thioester, 第53回ペプチド討論会, Oct. 2016. |
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| 152. | Takuya Morisaki, Masaya Denda, Jun Yamamoto, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : Development of N-sulfanylethylanilide (SEAlide)-based traceable linker for enrichment and selective labeling of target proteins, 第53回ペプチド討論会, Oct. 2016. |
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| 153. | Takahisa Jichu, Keisuke Aihara, Kohsuke Yamaoka, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Synthetic study of trichamide using Cys-free ligation, 第53回ペプチド討論会, Oct. 2016. |
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| 154. | Takahiro Nakamura, Akira Shigenaga, Naoto Naruse, Tsubasa Inokuma and Akira Otaka : Tailored Synthesis of 162-Residue S-Monoglycosylated GM2-Activator Protein (GM2AP) Analogues Applicable to the Preparation of a Protein Library, 第53回ペプチド討論会, Oct. 2016. |
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| 155. | Keisuke Aihara, Tetsuro Yoshimaru, Masato Komatsu, Akira Shigenaga, Toyomasa Katagiri and Akira Otaka : Development of stapled peptides targeting BIG3-PHB2 interaction in breast cancer cells, 第53回ペプチド討論会, Oct. 2016. |
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| 156. | Tomoki Kuwahara, Akira Mizuno, Hayato Hukuda, Mizuki Watanabe, Atsuhiro Kanda, Susumu Ishida, Akira Otaka and Satoshi Shuto : Design and synthesis of the spiro-cyclopropane scaffold peptidomimetics minicking both alpha-helix and beta-strand, 第53回ペプチド討論会, Oct. 2016. |
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| 157. | Kazuyoshi Kawazoe, Shinji Abe, Taro Shimizu, Tatsuhiro Ishida and Akira Otaka : 徳島大学発「インタラクティブYAKUGAKUJIN」の育成―新しい視点に立脚した教育の開発と実践―, 第1回日本薬学教育学大会, Aug. 2016. |
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| 158. | Chiharu Mizuguchi, Shiho Mikawa, 馬場 照彦, 島内 寿徳, Akira Shigenaga, Keiichiro Okuhira, Akira Otaka and Hiroyuki Saito : Iowa変異型アポA-Iによる脂質膜環境下でのアミロイド線維形成, 第4回日本アミロイド―シス研究会学術集会, Aug. 2016. |
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| 159. | Takahisa Jichu, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma and Akira Otaka : Cys-free ligationを用いた環状ペプチドTrichamideの合成研究, 第48回若手ペプチド夏の勉強会, Aug. 2016. |
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| 160. | Naoto Naruse, Kouhei Satou, Takahiro Nakamura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : リソソーム移行型GM2活性化タンパク質の合成研究, 第48回若手ペプチド夏の勉強会, Aug. 2016. |
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| 161. | 松浦 和則, 植村 明仁, 稲葉 央, Taiki Kohiki, Akira Shigenaga and Akira Otaka : 光誘起ペプチド繊維成長による走光性リポソームの創製, 第26回バイオ・高分子シンポジウム, Jul. 2016. |
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| 162. | Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 光応答型チオエステル等価体を用いた多成分One-pot NCL法の開発研究, 創薬懇話会2016 in 蓼科, Jun. 2016. |
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| 163. | Takahisa Jichu, Keisuke Aihara, Akira Shigenaga, Tsubasa Inokuma and Akira Otaka : 中分子創薬を指向した環状ペプチドTrichamideの合成研究, 創薬懇話会2016 in 蓼科, Jun. 2016. |
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| 164. | Kazuko YORITA, Sumire Kurosawa, Yuuri Yoshida, Akira Otaka, Yoshiki Kashiwada, Shigeki Sano, Noriaki Minakawa and Kiyoshi Fukui : ヒトD-アミノ酸酸化酵素のエフェクター探索と構造活性相関, 日本ビタミン学会第68回大会, Jun. 2016. |
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| 165. | Taiki Kohiki, Masaya Denda, Takuya Morisaki, Daisuke Tsuji, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : ''SEAL-tag''を基盤とした細胞内での標的タンパク質ラベル化法の開発, 日本ケミカルバイオロジー学会第11回年会, Jun. 2016. |
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| 166. | Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : 標的タンパク質精製ツール"SEAlide-based traceable linker"の開発, 日本ケミカルバイオロジー学会第11回年会, Jun. 2016. |
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| 167. | 松浦 和則, 植村 明仁, 中原 正彦, 古谷 昌大, Akira Shigenaga, Chiaki Komiya and Akira Otaka : 光誘起ペプチドナノファイバー成長の時空間制御, 第65回高分子学会年次学会, May 2016. |
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| 168. | Ryo Nadai, 武知 佑樹, Kazuchika Nishitsuji, 内村 健治, 加藤 くみ子, Akira Shigenaga, 川上 徹, Akira Otaka, 北條 裕信, Naomi Sakashita and Hiroyuki Saito : アルギニンペプチドの細胞膜透過はグリコサミノグリカン糖鎖へのエンタルピー依存的結合によって促進される, 日本膜学会第38年会, May 2016. |
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| 169. | Haruka Kawahara, Keiichiro Okuhira, Kouhei Tsuji, Yusuke Tsuda, Kyohei Morimoto, Hitoshi Kimura, Hirokazu Kariyazono, Risa Ohmura, Asato Ichino, Ryo Sugihara, Kazuchika Nishitsuji, Akira Shigenaga, Naomi Sakashita, Akira Otaka and Hiroyuki Saito : 光応答性アボ A-I 模倣ペプチドの開発研究, 日本薬学会第136年会, Mar. 2016. |
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| 170. | Akira Shigenaga and Akira Otaka : ペプチド化学を基盤としたケミカルバイオロジー研究のための基盤技術の開拓, 日本薬学会第136年会, Mar. 2016. |
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| 171. | Takahisa Jichu, Keisuke Aihara, Mitsuhiro Etoh, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 環状ペプチドTrichamideの合成研究, 日本薬学会第136年会, Mar. 2016. |
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| 172. | Mitsuhiro Etoh, Kyohei Morimoto, Kouhei Tsuji, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : チオエステル等価体としてのN-sulfanylethylcoumarinylamide (SECmide) の開発及びペプチド合成への応用, 日本薬学会第136年会, Mar. 2016. |
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| 173. | Takuya Morisaki, Masaya Denda, Takahiro Nakamura, Daisuke Tsuji, Jun Yamamoto, Tsubasa Inokuma, Kouji Itou, Akira Shigenaga and Akira Otaka : 標的タンパク質の高効率的同定を可能とする新規リンカー分子の開発研究, 日本薬学会第136年会, Mar. 2016. |
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| 174. | Naoto Naruse, Kouhei Satou, Takahiro Nakamura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : マンノース六リン酸修飾型GM2活性化タンパク質の合成研究, 日本薬学会第136年会, Mar. 2016. |
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| 175. | Kohsuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 光応答型チオエステル等価体を用いたOne-potタンパク質化学合成法の開発, 日本薬学会第136年会, Mar. 2016. |
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| 176. | 高橋 伶奈, 種子島 幸祐, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and 原 孝彦 : ケモカインCXCL14は癌細胞のヘパラン硫酸に高親和性で結合する, 第38回日本分子生物学会年会・第88回日本生化学会大会合同大会, Dec. 2015. |
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| 177. | Akira Otaka : 創薬人育成教育から見えてきた薬学教育の将来について-薬の顔相学-, 第25回医療薬学会年会「教育セミナー」, Nov. 2015. |
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| 178. | Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Development of intein-inspired peptide bond processing device, 第52回ペプチド討論会, Nov. 2015. |
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| 179. | Rin Miyajima, Yusuke Tsuda, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Preparation of peptide thioesters from naturally occuring sequences using a chemical protocol, 第52回ペプチド討論会, Nov. 2015. |
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| 180. | Shinji Abe, Chiemi Sato, Kaori Yamamoto, Mami Azuma and Akira Otaka : 薬学体験実習における屋根瓦方式導入の有用性, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会 (高知), Nov. 2015. |
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| 181. | Kohki Matsuoka, Youichi Sato, Akira Otaka and Aiko Yamauchi : 薬物の胎児毒性に関する機械学習による予測と化学構造特性の解析, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, Nov. 2015. |
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| 182. | Naoto Okada, Shinji Abe, Chiemi Sato, Mami Azuma, Kazuyoshi Kawazoe, Akira Otaka and Keisuke Ishizawa : 徳島大学病院における模擬体験型学習を用いた実務実習の評価, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2015. |
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| 183. | Chiemi Sato, Kaori Yamamoto, Shinji Abe, Naoto Okada, Koichiro Tsuchiya, Mami Azuma and Akira Otaka : 病院・薬局実務実習における実習生の主体性育成に向けての取組み:課題発見型レポートの効果の検証, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2015. |
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| 184. | Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Kensuke Orihara, Tsubasa Inokuma, Kouji Itou, Kozo Shishido, Akira Shigenaga and Akira Otaka : SEAlideを利用した標的タンパク質精製ツール ''トレーサブルリンカー''の開発研究, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2015. |
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| 185. | Kosuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 多成分縮合を可能とする光応答型チオエステル等価体の開発, 第54回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2015. |
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| 186. | Tsubasa Inokuma, Kazuya Iwamoto, Ken Sakamoto, Akira Shigenaga and Akira Otaka : N-Sulfanylethylanilide (SEAlide)を基盤としたタンパク質-ペプチドコンジュゲーション法の開発, 第41回反応と合成の進歩シンポジウム, Oct. 2015. |
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| 187. | Takahisa Jichu, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : α-イミノカルボン酸誘導体の効率的合成法の開発と非天然α-アミノ酸合成への応用, 第41回反応と合成の進歩シンポジウム, Oct. 2015. |
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| 188. | Akira Shigenaga, Kohei Sato, Tsubasa Inokuma and Akira Otaka : 非天然型アミノ酸を含むタンパク質の調製を志向したタンパク質完全化学合成法の開拓, 第64回高分子討論会(特定テーマ 融合マテリアルの精密構造制御と機能創製), Sep. 2015. |
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| 189. | Takahisa Jichu, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : チアゾール含有環状ペプチドTrichamideの合成研究, 第三十一回若手化学者のための化学道場, Aug. 2015. |
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| 190. | Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : タンパク質自己編集システムを範としたアミド結合切断反応の開発, 第三十一回若手化学者のための化学道場, Aug. 2015. |
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| 191. | Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Kensuke Orihara, Tsubasa Inokuma, Kouji Itou, Kozo Shishido, Akira Shigenaga and Akira Otaka : 標的タンパク質の効率的精製および選択的ラベル化を可能とするケミカルツールの開発研究, 第三十一回若手化学者のための化学道場, Aug. 2015. |
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| 192. | Kosuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 光応答型チオエステル等価体を利用した多成分One-pot NCL法の開発, 第三十一回若手化学者のための化学道場, Aug. 2015. |
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| 193. | Masaya Denda, Takuya Morisaki, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : N-Sアシル基転移反応を基盤としたin cellタンパク質ラベル化法の開発, 第47回若手ペプチド夏の勉強会, Aug. 2015. |
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| 194. | Takuya Morisaki, Masaya Denda, Daisuke Tsuji, Jun Yamamoto, Keisuke Orihara, Tsubasa Inokuma, Kouji Itou, Kozo Shishido, Akira Shigenaga and Akira Otaka : 標的タンパク質の高効率同定を可能とするケミカルツールの開発研究, 第47回若手ペプチド夏の勉強会, Aug. 2015. |
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| 195. | Kosuke Yamaoka, Keisuke Aihara, Naoto Naruse, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 光応答性補助基を用いた4成分One-pot NCL法の開発, 第47回若手ペプチド夏の勉強会, Aug. 2015. |
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| 196. | Masaya Denda, Takuya Morisaki, Tsubasa Inokuma, Youichi Sato, Aiko Yamauchi, Akira Shigenaga and Akira Otaka : N-Sアシル基転移反応を利用した新規ラベル化試薬の開発, 創薬懇話会2015 in 徳島, Jul. 2015. |
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| 197. | Yusuke Tsuda, Akira Shigenaga, Kohei Tsuji, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka : タンパク質半化学合成を指向した配列特異的チオエステル化法の開発, 創薬懇話会2015 in 徳島, Jul. 2015. |
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| 198. | Akira Otaka, Kohei Sato and Akira Shigenaga : 化学合成によるタンパク質製剤調製への挑戦, 第15回日本蛋白質科学会年会, Jun. 2015. |
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| 199. | Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Tsubasa Inokuma and Akira Otaka : GM2活性化タンパク質誘導体の第二世代化学合成法の確立, 日本ケミカルバイオロジー学会第10回年会, Jun. 2015. |
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| 200. | Shiho Mikawa, Chiharu Mizuguchi, Kouhei Tsuji, Akira Shigenaga, 島内 寿徳, Akira Otaka and Hiroyuki Saito : アポA-Iアミロイド線維形成に与える脂質膜とヘパリンの影響, 日本膜学会第37年会, May 2015. |
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| 201. | 武知 佑樹, Kento Tanaka, Kouhei Tsuji, 麻見 安雄, 井澤 浩則, Akira Shigenaga, Akira Otaka, 川上 亘作 and Hiroyuki Saito : シクロデキストリン架橋型キトサン-pH応答性ペプチド複合体による細胞コレステロール排出促進作用, 日本膜学会第37年会, May 2015. |
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| 202. | Shiho Mikawa, Chiharu Mizuguchi, Kouhei Tsuji, 馬場 照彦, Akira Shigenaga, Akira Otaka and Hiroyuki Saito : アルギニン変異apoA-Iフラグメントのアミロイド線維形成性, 日本薬学会第135年会, Mar. 2015. |
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| 203. | Kimihito Naruse, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : M6P修飾型GM2APの合成検討, 日本薬学会第135年会, Mar. 2015. |
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| 204. | Keiji Ogura, Hiroko Hirakawa, Takuya Morisaki, Jun Yamamoto, Koji Ebisuno, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya, Akira Shigenaga and Akira Otaka : 低酸素環境応答型アミノ酸の開発研究, 日本薬学会第135年会, Mar. 2015. |
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| 205. | Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : プロテインスプライシング模倣型ペプチド結合切断デバイスの開発研究, 日本薬学会第135年会, Mar. 2015. |
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| 206. | Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto, Tsubasa Inokuma and Akira Otaka : GM2活性化タンパク質誘導体の第二世代化学合成法の開発研究, 日本薬学会第135年会, Mar. 2015. |
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| 207. | Miku Kita, Kohei Sato, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Protein trans-splicingの高速化を指向したN-intein合成法の開発研究, 日本薬学会第135年会, Mar. 2015. |
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| 208. | Jun Yamamoto, Takuya Morisaki, Miku Kita, Chiaki Komiya, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : 標的タンパク質の効率的濃縮および選択的ラベル化を可能とするチオール応答型トレーサブルリンカーの開発, 第32回メディシナルケミストリーシンポジウム, Nov. 2014. |
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| 209. | Koji Ebisuno, Masaya Denda, Keiji Ogura, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 細胞内シグナル伝達機構解明を指向したケージド非水解性リン酸化アミノ酸の合成とその機能評価, 第40回反応と合成の進歩シンポジウム, Nov. 2014. |
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| 210. | Keisuke Aihara, Chiaki Komiya, Akira Shigenaga, Tsubasa Inokuma, Daisuke Takahashi and Akira Otaka : 固-液融合型ペプチド合成法を用いた架橋ペプチド効率的合成法の開発, 第40回反応と合成の進歩シンポジウム, Nov. 2014. |
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| 211. | Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : タンパク質機能制御を指向したプロテインスプライシング模倣型アミド結合切断反応の開発, 第40回反応と合成の進歩シンポジウム, Nov. 2014. |
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| 212. | 山岡 朋美, Licht Miyamoto, 川崎 彩, 山根 萌, 高橋 梨恵, Keisuke Ishizawa, Rin Miyajima, Akira Shigenaga, Akira Otaka and Koichiro Tsuchiya : Leptinによる骨格筋培養細胞での代謝制御作用におけるSIRT1の役割, 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014. |
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| 213. | Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kouhei Satou, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka : 新規タンパク質チオエステル調製法の開発, 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014. |
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| 214. | Takahiro Nakamura, Akira Shigenaga, Kouhei Satou, Yusuke Tsuda, Ken Sakamoto, Tsubasa Inokuma and Akira Otaka : GM2活性化タンパク質アナログの第二世代化学合成法の開発研究, 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014. |
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| 215. | Mitsuhiro Etoh, Masaya Denda, Kouhei Satou, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : ペプチドチオエステル調製のためのクマリン型補助基の開発, 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2014. |
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| 216. | Hirokazu Kariyazono, Wataru Shimmura, Kouhei Tsuji, Akira Shigenaga, Akira Otaka and Hiroyuki Saito : DESIGN OF NANODISC SCAFFOLD PEPTIDE (NSP), 第51回ペプチド討論会, Oct. 2014. |
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| 217. | Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Keisuke Kitakaze, Takahiro Nakamura, Tsubasa Inokuma, Kouji Itou and Akira Otaka : Preparation of Peptide/protein Thioesters Using a Chemical Protocol Applicable to Expressed Proteins., 51th The Japanese Peptide Society, Oct. 2014. |
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| 218. | Mitsuhiro Eto, Masaya Denda, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : Preparation of peptide thioesters using N-sulfanylethylcoumarinylamide peptide, 第51回ペプチド討論会, Oct. 2014. |
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| 219. | Kohei Tsuji, Kohei Sato, Ken Sakamoto, Kosuke Tanegashima, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka : One-pot chemical synthesis of CXCL14 using N-sulfanylethylanilide peptide, 第51回ペプチド討論会, Oct. 2014. |
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| 220. | Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Tsubasa Inokuma, Daisuke Tsuji, Kouji Itou and Akira Otaka : Development of N-glycosylated asparagine ligation and its application to total chemical synthesis of GM2 activator protein, 51th The Japanese Peptide Society, Oct. 2014. |
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| 221. | Kazunori Matsuura, Masahiro Furutani, Akihito Uemura, Akira Shigenaga, Chiaki Komiya and Akira Otaka : 光切断により誘起されるペプチドナノファイバー成長システムの創製, 第63回高分子討論会, Sep. 2014. |
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| 222. | Akira Otaka : 薬学教育の現状と期待(創薬研究から), 日本学術会議日本薬学会共催シンポジウム「薬学教育への期待:4年制薬学教育のあり方と参照基準の作成に向けて」, Aug. 2014. |
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| 223. | Kohei Tsuji, Akira Shigenaga, Tsubasa Inokuma, Takahiko Hara and Akira Otaka : 二量体化したCXCL14 C端側領域はCXCL12アンタゴニストとなる, 第46回若手ペプチド夏の勉強会, Aug. 2014. |
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| 224. | Yusuke Tsuda, Akira Shigenaga, Masaya Denda, Kohei Sato, Takahiro Nakamura, Tsubasa Inokuma and Akira Otaka : 新規タンパク質チオエステル調製法 ''SQAT system'' の開発, 第46回若手ペプチド夏の勉強会, Aug. 2014. |
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| 225. | Takahiro Nakamura, Akira Shigenaga, Kohei Sato, Yusuke Tsuda, Ken Sakamoto, Tsubasa Inokuma and Akira Otaka : 第二世代hGM2AP完全化学合成法の開発研究, 第46回若手ペプチド夏の勉強会, Aug. 2014. |
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| 226. | Mitsuhiro Eto, Masaya Denda, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : N-Sulfanylethylcoumarinylamide (SECmide) を用いたペプチドチオエステル調製法の開発, 第46回若手ペプチド夏の勉強会, Aug. 2014. |
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| 227. | Chiaki Komiya, Keisuke Aihara, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : アスパラギン誘導体を用いたインテイン模倣型ペプチド結合切断システムの開発, 第46回若手ペプチド夏の勉強会, Aug. 2014. |
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| 228. | Rin Miyajima, Yusuke Tsuda, Kohei Sato, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 天然型アミノ酸配列からのチオエステル合成, 第46回若手ペプチド夏の勉強会, Aug. 2014. |
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| 229. | Takuya Morisaki, Jun Yamamoto, Akira Shigenaga, Tsubasa Inokuma and Akira Otaka : SEAlideを基盤としたトレーサブルリンカーの開発研究, 第46回若手ペプチド夏の勉強会, Aug. 2014. |
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| 230. | Keisuke Aihara, Chiaki Komiya, Akira Shigenaga, Tsubasa Inokuma, Daisuke Takahashi and Akira Otaka : オレフィンメタセシスを用いた架橋ペプチド効率的合成法の開発, 創薬懇話会2014, Jul. 2014. |
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| 231. | Yusuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura, Keisuke Kitakaze, Tsubasa Inokuma, Kouji Itou and Akira Otaka : 天然アミノ酸配列に適用可能な新規タンパク質チオエステル合成法の開発, 日本ケミカルバイオロジー学会第9回年会, Jun. 2014. |
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| 232. | Miku Kita, Jun Yamamoto, Koji Ebisuno, Chiaki Komiya, Licht Miyamoto, Koichiro Tsuchiya, Akira Shigenaga and Akira Otaka : 過酸化水素応答型ペプチド結合切断デバイスの開発研究, 日本ケミカルバイオロジー学会第9回年会, Jun. 2014. |
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| 233. | Masato Moriguchi, Masahiro Furutani, Akira Shigenaga, Chiaki Komiya, Akira Otaka and Kazunori Matsuura : 光切断によりβ-シート繊維成長するアニオン性ペプチドの分子設計, 第63回高分子学会年次大会, May 2014. |
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| 234. | Emi Adachi, Kouhei Tsuji, 川島 浩之, Akira Shigenaga, Kohjiro Nagao, 赤路 健一, Akira Otaka and Hiroyuki Saito : フラグメントペプチドを用いたアポA-Iアミロイド線維形成領域の同定, 日本薬学会第134年会, Mar. 2014. |
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| 235. | Kohei Tsuji, Kohei Sato, Ken Sakamoto, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : SEAlideペプチドを用いたCXCL14のone-pot化学合成法の開発, 日本薬学会第134年会, Mar. 2014. |
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| 236. | Akira Otaka and Akira Shigenaga : インテインに学ぶ標的タンパク質研究手法の開発, 日本薬学会第134年会, Mar. 2014. |
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| 237. | Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : GM2活性化タンパク質の収束的合成研究, 日本薬学会第134年会, Mar. 2014. |
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| 238. | Masaya Denda, Jun Yamamoto, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : ラベル化試薬"SEAL-tag"の開発とCOX-1およびhCA1のラベル化, 日本薬学会第134年会, Mar. 2014. |
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| 239. | Ysuke Tsuda, Akira Shigenaga, Kohei Sato, Takahiro Nakamura, Keisuke Kitakaze, Tsubasa Inokuma, Kouji Itou and Akira Otaka : 発現タンパク質に適用可能な新規タンパク質チオエステル合成法の開発, 日本薬学会第134年会, Mar. 2014. |
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| 240. | Mitsuhiro Eto, Masaya Denda, Kohei Sato, Ken Sakamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : N-Sulfanylethylcoumarinylamide (SECmide) を用いたペプチドチオエステル調製法の開発, 日本薬学会第134年会, Mar. 2014. |
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| 241. | Chiaki Komiya, Jun Yamamoto, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 還元的N-N結合切断反応の改良を基盤とした刺激応答型アミノ酸の実用的合成法の検討, 日本薬学会第134年会, Mar. 2014. |
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| 242. | Rin Miyajima, Yusuke Tsuda, Kohei Sato, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : 天然アミノ酸配列に適用可能な新規ペプチドチオエステル合成法の開発, 日本薬学会第134年会, Mar. 2014. |
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| 243. | Takuya Morisaki, Jun Yamamoto, Akira Shigenaga, Youichi Sato, Tsubasa Inokuma, Aiko Yamauchi and Akira Otaka : 標的タンパク質の効率的濃縮および選択的ラベル化を可能とする新規リンカー分子の開発, 日本薬学会第134年会, Mar. 2014. |
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| 244. | Masahiro Furutani, Kazunori Matsuura, Akira Shigenaga, Chiaki Komiya and Akira Otaka : 光切断によりナノファイバー成長誘起されるペプチド分子システムの創製, 日本化学会第94春季年会, Mar. 2014. |
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| 245. | Kohei Sato, Masaya Denda, Jun Yamamoto, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : タンパク質機能解明を指向した新規ラベル化試薬''SEAL-tag''の開発研究, 第31回メディシナルケミストリーシンポジウム, Nov. 2013. |
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| 246. | Keisuke Aihara, Akira Shigenaga and Akira Otaka : オレフィンメタセシスを用いたGlu-Lys架橋ペプチド新規合成法の開発研究, 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2013. |
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| 247. | Koji Ebisuno, Masaya Denda, Keiji Ogura, Akira Shigenaga and Akira Otaka : ケージド非水解性リン酸化アミノ酸含有ペプチドの合成法の確立と14-3-3βタンパク質への結合能の評価, 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2013. |
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| 248. | Chiaki Komiya, Jun Yamamoto, Akira Shigenaga and Akira Otaka : 刺激応答型アミノ酸の実用的合成法の開発検討, 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2013. |
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| 249. | Tatsuhiko Shimizu, Rin Miyajima, Ken Sakamoto, Akira Shigenaga and Akira Otaka : SEAlide peptideを用いた簡便なペプチドチオカルボン酸合成法の開発, 第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2013. |
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| 250. | Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : 標的タンパク質精製・選択的ラベル化ツール''Traceable Linker''の開発研究, 生命分子機能研究会2013学術集会, Sep. 2013. |
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| 251. | Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : リソソーム病治療を指向したGM2活性化タンパク質アナログの完全化学合成, 生命分子機能研究会2013学術集会, Sep. 2013. |
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| 252. | Akira Otaka : 自然に学ぶペプチド化学, 第45回若手ペプチド夏の勉強会, Jul. 2013. |
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| 253. | Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : 標的タンパク質を釣り上げろ!∼トレーサブルリンカーの開発∼, 第45回若手ペプチド夏の勉強会, Jul. 2013. |
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| 254. | Keisuke Aihara, Akira Shigenaga and Akira Otaka : オレフィンメタセシスを用いたLys-Glu架橋ペプチド新規合成法の開発研究, 第45回若手ペプチド夏の勉強会, Jul. 2013. |
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| 255. | Ken Sakamoto, Kohei Sato, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : SEAlideユニットの効率的合成法の開発とその応用, 第45回若手ペプチド夏の勉強会, Jul. 2013. |
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| 256. | Miku Kita, Jun Yamamoto, Koji Ebisuno, Chiaki Komiya, Akira Shigenaga and Akira Otaka : 過酸化水素応答型ペプチド結合切断能を有するアミノ酸の開発, 第45回若手ペプチド夏の勉強会, Jul. 2013. |
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| 257. | Takahiro Nakamura, Yusuke Tsuda, Kohei Sato, Ken Sakamoto, Akira Shigenaga and Akira Otaka : NCL法におけるプロリルチオエステルの有用性の検討, 第45回若手ペプチド夏の勉強会, Jul. 2013. |
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| 258. | Akira Otaka : ペプチド・タンパク質を基盤とする創薬展開への化学基盤の開拓, 創薬懇話会2013, Jul. 2013. |
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| 259. | Koji Ebisuno, Masaya Denda, 小倉 圭司, Akira Shigenaga and Akira Otaka : ケージド非水解性リン酸化アミノ酸含有ペプチドの合成と14-3-3βタンパク質への結合能評価, 日本ケミカルバイオロジー学会第8回年会, Jun. 2013. |
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| 260. | Akira Otaka : 標的タンパク質同定に向けたトレーサブルリンカーの開発, 新学術領域研究「天然物ケミカルバイオロジー∼分子標的と活性制御∼」第4回公開シンポジウム, May 2013. |
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| 261. | Jun Yamamoto, Miku Kita, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : 標的タンパク質の精製・選択的ラベル化ツール「トレーサブルリンカー」の開発, 日本薬学会第133回年会, Mar. 2013. |
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| 262. | Miku Kita, Jun Yamamoto, Koji Ebisuno, Akira Shigenaga and Akira Otaka : 過酸化水素応答型アミノ酸の開発研究, 日本薬学会第133回年会, Mar. 2013. |
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| 263. | 折原 賢祐, 小林 久剛, 兼松 誠, Masahiro Yoshida, 中村 崇洋, Daisuke Tsuji, Kouji Itou, Akira Shigenaga, Akira Otaka and Kozo Shishido : Aspergillide Cの活性評価および標的タンパクの探索, 日本薬学会第133年会, Mar. 2013. |
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| 264. | Jun Yamamoto, Masaya Denda, Koji Ebisuno, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : フッ化物イオン応答型トレーサブルリンカーを利用したタンパク質精製実験, 第30回メディシナルケミストリーシンポジウム, Nov. 2012. |
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| 265. | Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Hao Ding, Masaya Denda, Takahiko Hara and Akira Otaka : CXCL14受容体の同定とそのアンタゴニストペプチドの合成, 第30回メディシナルケミストリーシンポジウム, Nov. 2012. |
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| 266. | Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : リソソーム病治療薬を指向したヒトGM2活性化タンパク質誘導体の化学合成と活性評価, 第30回メディシナルケミストリーシンポジウム, Nov. 2012. |
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| 267. | Koji Ebisuno, Masaya Denda, Keiji Ogura, Taku Terawaki, Akira Shigenaga and Akira Otaka : ケージド非水解性リン酸化アミノ酸含有ペプチドの合成とタンパク質結合能の評価, 第30回メディシナルケミストリーシンポジウム, Nov. 2012. |
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| 268. | Masaya Denda, Jun Yamamoto, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : タンパク質選択的ラベル化法の開発研究, 第51回日本薬学会・日本薬剤師会,日本病院薬剤師会中国四国支部学術大会, Nov. 2012. |
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| 269. | Miku Kita, Jun Yamamoto, Koji Ebisuno, Akira Shigenaga and Akira Otaka : 酸化ストレス応答型アミノ酸の開発研究, 第51回日本薬学会・日本薬剤師会,日本病院薬剤師会中国四国支部学術大会, Nov. 2012. |
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| 270. | Akira Shigenaga, Keiji Ogura, Hiroko Hirakawa, Jun Yamamoto, Koji Ebisuno, Licht Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Akira Otaka : Design and synthesis of hypoxia-responsive amino acid which causes peptide bond cleavage in hypoxic cells, 第49回ペプチド討論会, Nov. 2012. |
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| 271. | Ken Sakamoto, Kohei Sato, Akira Shigenaga, Kohei Tsuji, Shugo Tsuda, Hajime Hibino, Yuji Nishiuchi and Akira Otaka : Development of efficient synthetic protocol for Fmoc amino acid-incorporated N-sulfanylethyl-aniline linker as peptide thioester precursor, 第49回ペプチド討論会, Nov. 2012. |
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| 272. | Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : Convergent chemical synthesis of human GM2 activator protein analog using SEAlide chemistry, 第49回ペプチド討論会, Nov. 2012. |
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| 273. | Kohei Tsuji, Kosuke Tanegashima, Akira Shigenaga, Keisuke Aihara, Masaya Denda, Hao Ding, Takahiko Hara and Akira Otaka : Synthesis of antagonistic peptide for putative CXCL14 receptor proteins and their identification, 第49回ペプチド討論会, Nov. 2012. |
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| 274. | Akira Shigenaga and Akira Otaka : ''化学''でペプチド・タンパク質をあやつる, 第28回若手化学者のための化学道場, Sep. 2012. |
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| 275. | Akira Otaka : 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦, アステラス製薬シンポジウム, Aug. 2012. |
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| 276. | Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka : 4-チオプロリンを用いたDual-kinetic NCL法の開発, 第44回若手ペプチド夏の勉強会, Aug. 2012. |
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| 277. | Kohei Sato, Keisuke Kitakaze, Ken Sakamoto, Akira Shigenaga, Daisuke Tsuji, Kouji Itou and Akira Otaka : タンパク質完全化学合成∼ケミストによるタンパク質医薬品開発を目指して∼, 第44回若手ペプチド夏の勉強会, Aug. 2012. |
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| 278. | Masaya Denda, Jun Yamamoto, Kohei Sato, Ken Sakamoto, Akira Shigenaga, Youichi Sato, Yoshiyuki Yoshimura, Aiko Yamauchi and Akira Otaka : 新規タンパク質選択的ラベル化試薬''SEAL-tag''の開発研究, 日本ケミカルバイオロジー学会第7回年会, Jun. 2012. |
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| 279. | Jun Yamamoto, Masaya Denda, Koji Ebisuno, Akira Shigenaga, Youichi Sato, Aiko Yamauchi and Akira Otaka : フッ化物イオン応答型トレーサブルリンカーを利用したタンパク質精製法の開発, 日本ケミカルバイオロジー学会第7回年会, Jun. 2012. |
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| 280. | Akira Otaka : 情報発信型人工タンパク質創製に向けた有機・生物有機化学的挑戦, 第101回有機合成シンポジウム2012年【春】, Jun. 2012. |
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| 281. | Ken Sakamoto, Kohei Sato, Shugo Tsuda, Akira Shigenaga and Akira Otaka : タンパク質化学合成を指向したN-アミノアシルN-置換アニリンリンカーの効率的合成法の開発, 日本薬学会第132回年会, Mar. 2012. |
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| 282. | Koji Ebisuno, Jun Yamamoto, Akira Shigenaga and Akira Otaka : 新規チオール応答型アミノ酸の合成とDNA放出システムへの展開, 日本薬学会第132回年会, Mar. 2012. |
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| 283. | Keisuke Aihara, Kohei Tsuji, Hao Ding, Masaya Denda, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : CXCL14・CXCL12デュアルアンタゴニストペプチドの創製, 日本薬学会第132回年会, Mar. 2012. |
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| 284. | Masaya Denda, Keiji Ogura, Koji Ebisuno, Akira Shigenaga and Akira Otaka : リン酸化タンパク質の機能解明に向けたケージド非水解性リン酸化アミノ酸含有ペプチドの合成研究, 日本薬学会第132回年会, Mar. 2012. |
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| 285. | Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka : 4-チオプロリンを用いたNative Chemical Ligation法の開発, 日本薬学会第132回年会, Mar. 2012. |
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| 286. | Jun Yamamoto, Tomohiro Tanaka, Masaya Denda, Koji Ebisuno, Wataru Nomura, Akira Shigenaga, Hirokazu Tamamura and Akira Otaka : フッ化物イオン応答型アミノ酸の開発と標的タンパク質精製ツールへの応用, 日本薬学会第132回年会, Mar. 2012. |
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| 287. | Akira Otaka : 標的タンパク質捕捉の科学, 徳島大学大学院ヘルスバイオサイエンス研究部第8回公開シンポジウム, Nov. 2011. |
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| 288. | Keiji Ogura, Hiroko Hirakawa, Masaya Denda, Akira Shigenaga and Akira Otaka : AMP化タンパク質の機能解明を指向したペプチド性分子ツールの開発, 第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011. |
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| 289. | Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : CXCL14およびその誘導体の効率的合成法の開発と活性評価, 第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011. |
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| 290. | Masaya Denda, Keiji Ogura, Koji Ebisuno, Akira Shigenaga and Akira Otaka : リン酸化タンパク質の機能解明に向けた紫外線応答型リン酸化アミノ酸誘導体の合成研究, 第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011. |
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| 291. | Ken Sakamoto, Kohei Sato, Shugo Tsuda, Akira Shigenaga and Akira Otaka : ペプチドチオエステル合成用アニリン型補助基への効率的アミノ酸導入法の開発, 第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011. |
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| 292. | Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka : タンパク質AMP化の生理学的意義解明を指向した新規分子ツールの開発, 第37回反応と合成の進歩シンポジウム, Nov. 2011. |
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| 293. | Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka : 4-メルカプトプロリンを用いたペプチドフラグメント縮合法の開発, 第37回反応と合成の進歩シンポジウム, Nov. 2011. |
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| 294. | Kohei Sato, Shugo Tsuda, Ken Sakamoto, Akira Shigenaga and Akira Otaka : タンパク質化学合成を指向したワンポット4成分連続縮合法の開発, 第37回反応と合成の進歩シンポジウム, Nov. 2011. |
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| 295. | Hao Ding, Kohei Sato, Ko Morishita, Akira Shigenaga and Akira Otaka : Double-kinetically controlled proline ligation, 第48回ペプチド討論会, Sep. 2011. |
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| 296. | Akira Shigenaga, Hiroko Hirakawa, Jun Yamamoto, Keiji Ogura, Masaya Denda, Keiko Yamaguchi and Akira Otaka : Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer, 第48回ペプチド討論会, Sep. 2011. |
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| 297. | Kohei Sato, Shugo Tsuda, Ken Sakamoto, Akira Shigenaga and Akira Otaka : N-Sulfanylethylanilide peptide: a peptide thioester equivalent which can directly participate in native chemical ligation, 第48回ペプチド討論会, Sep. 2011. |
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| 298. | Akira Otaka and Akira Shigenaga : Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device, 日本生物物理学会第49回年会, Sep. 2011. |
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| 299. | Kohei Sato, Shugo Tsuda, Ken Sakamoto, Akira Shigenaga and Akira Otaka : 簡便かつ効率的タンパク質化学合成法の開発, 創薬懇話会2011, Jul. 2011. |
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| 300. | Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka : タンパク質AMP化の生理学的意義解明に向けたAMP化アミノ酸誘導体の創製, 創薬懇話会2011, Jul. 2011. |
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| 301. | Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka : AMP化タンパク質の機能解明に向けたAMP化アミノ酸誘導体の創製, 日本ケミカルバイオロジー学会第6回年会, May 2011. |
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| 302. | Daisuke Tsuji, Kentaroh Namba, 浦上 裕行, 辻 耕平, Akira Shigenaga, Akira Otaka, Yoshiki Kashiwada, Yoshihisa Takaishi and Kouji Itou : ヒトiPS細胞に対する神経分化誘導能を持つ新規化合物の探索, 日本薬学会 第131年会, Mar. 2011. |
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| 303. | Akira Shigenaga, Jun Yamamoto, Naomi Nishioka, Keiji Ogura, Masaya Denda and Akira Otaka : プロリン型触媒を用いた刺激応答型アミノ酸の不斉合成, 日本薬学会年会, Mar. 2011. |
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| 304. | Jun Yamamoto, Nami Maeda, Tomohiro Tanaka, Masaya Denda, Akira Shigenaga, Wataru Nomura, Hirokazu Tamamura and Akira Otaka : 標的タンパク質の効率的濃縮と同定を指向したトレーサブルリンカーの開発, 日本薬学会年会, Mar. 2011. |
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| 305. | Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : CXCL14およびその誘導体の多様性指向型化学合成とその活性評価, 日本薬学会年会, Mar. 2011. |
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| 306. | Kohei Sato, Shugo Tsuda, Yoshitake Sumikawa, Kohei Tsuji, Masaya Denda, Ken Sakamoto, Akira Shigenaga and Akira Otaka : クリプトチオエステル:ネイティブケミカルライゲーションに直接適用可能なペプチドチオエステル等価体, 日本薬学会年会, Mar. 2011. |
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| 307. | Daisuke Tsuji, 難波 建多郎, 浦上 裕行, Akira Shigenaga, Akira Otaka, Yoshiki Kashiwada, Yoshihisa Takaishi and Kouji Itou : 未分化細胞に対する神経分化誘導作用を持つ化合物の探索と構造活性相関, BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会), Dec. 2010. |
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| 308. | Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka : AMP化タンパク質の機能解明に向けたフォスファターゼ抵抗性AMP化アミノ酸の創製, 第29回メディシナルケミストリーシンポジウム, Nov. 2010. |
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| 309. | Jun Yamamoto, Masaya Denda, Nami Maeda, Akira Shigenaga and Akira Otaka : 標的タンパク質の効率的濃縮と同定を指向したCleavable Linkerの創製, 第29回メディシナルケミストリーシンポジウム, Nov. 2010. |
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| 310. | Kohei Tsuji, Yoshitake Sumikawa, Kosuke Tanegashima, Akira Shigenaga, Takahiko Hara and Akira Otaka : ライブラリ構築を志向したCXCL14およびその誘導体の合成と活性評価, 創薬懇話会2010, Nov. 2010. |
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| 311. | Ko Morishita, Keiko Yamaguchi, Hao Ding, Akira Shigenaga, Kenichi Akaji and Akira Otaka : システインプロテアーゼの活性調節を指向した機能性分子の開発, 第49回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2010. |
|
| 312. | Jun Yamamoto, Masaya Denda, Nami Maeda, Akira Shigenaga and Akira Otaka : 標的タンパク質の効率的濃縮と同定を指向したCleavable Linkerの開発, 第49回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2010. |
|
| 313. | Kohei Tsuji, Yoko Yamaki, Jun Yamamoto, Akira Shigenaga, Yasuyuki Shimohigashi and Akira Otaka : Synthesis of fluoroalkene dipeptide isosteres (FADIs) using intramolecular redox reaction with their incorporation into biologically active peptide, 第38回構造活性相関シンポジウム, Oct. 2010. |
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| 314. | Jun Yamamoto, Nami Maeda, Akira Shigenaga and Akira Otaka : ターゲットタンパク質の効率的濃縮と同定を指向したCleavable Linkerの開発, 日本ケミカルバイオロジー学会第5回年会, May 2010. |
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| 315. | Akira Shigenaga and Akira Otaka : 刺激応答型ペプチド結合切断反応を基盤としたペプチド機能制御, 日本薬学会年会, Mar. 2010. |
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| 316. | Kohei Tsuji, Jun Yamamoto, Yoko Yamaki, Akira Shigenaga and Akira Otaka : 分子内Redox反応を利用したフルオロアルケンジペプチドイソスターの合成とそのα-アルキル化の検討, 日本薬学会年会, Mar. 2010. |
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| 317. | Kohei Sato, Shugo Tsuda, Nami Maeda, Akira Shigenaga and Akira Otaka : N-置換アニリン型補助基の生理活性ペプチド合成への展開, 日本薬学会年会, Mar. 2010. |
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| 318. | Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka : AMP化タンパク質の機能解明に向けた非水解性AMP化アミノ酸の創製, 日本薬学会年会, Mar. 2010. |
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| 319. | Jun Yamamoto, Yoshitake Sumikawa, Akira Shigenaga, Toshiaki Furuta and Akira Otaka : 近赤外二光子励起応答型ペプチドの開発およびその光反応性の測定, 日本薬学会年会, Mar. 2010. |
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| 320. | Ko Morishita, Keiko Yamaguchi, Akira Shigenaga, Kenichi Akaji and Akira Otaka : チオールプロテアーゼの機能制御を指向した機能性分子の開発, 日本薬学会年会, Mar. 2010. |
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| 321. | Jun Yamamoto, Yoko Yamaki, Kohei Tsuji, Akira Shigenaga and Akira Otaka : 分子内Redox反応を利用したフルオロアルケンジペプチドイソスターの合成とクライゼン型転位によるα-アリル化の検討, 創薬懇話会2009, Dec. 2009. |
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| 322. | Kou Morishita, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka : チオールプロテアーゼの活性制御を指向した刺激応答型チオール放出システムの開発, 第28回メディシナルケミストリーシンポジウム, Nov. 2009. |
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| 323. | Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka : ペプチドチオカルボン酸の効率的合成と新規ペプチドフラグメント縮合法への適用, 第35回反応と合成の進歩シンポジウム, Nov. 2009. |
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| 324. | Akira Shigenaga, Yukiko Nishiyama, Nami Maeda and Akira Otaka : Synthesis of cyclic peptides via on resin-intramolecular native chemical ligation followed by reductive release from resin, 第46回ペプチド討論会, Nov. 2009. |
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| 325. | Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka : Efficient synthesis of peptide thioacids and their application to sequential NCL, ケミカルバイオロジー学会 第4回年会, May 2009. |
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| 326. | Hiroko Hirakawa, Naomi Nishioka, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka : The application of a photo-responsive amino acid to caged ceramides, ケミカルバイオロジー学会 第4回年会, May 2009. |
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| 327. | Akira Shigenaga, Shugo Tsuda, Yoshitake Sumikawa and Akira Otaka : Synthesis of peptide thioesters utilizing N-substituted anilide auxiliaries, ケミカルバイオロジー学会 第4回年会, May 2009. |
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| 328. | Akira Shigenaga, Jun Yamamoto, Hiroko Hirakawa, Keiko Yamaguchi and Akira Otaka : 任意の刺激応答型ペプチド結合切断デバイスの反応速度に与えるアミノ酸配列の影響, 日本薬学会年会, Mar. 2009. |
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| 329. | Nami Maeda, Shugo Tsuda, Sachie Ishizawa, Akira Shigenaga and Akira Otaka : 分子内NCLを利用した環状ペプチド合成法の開発(1), 日本薬学会年会, Mar. 2009. |
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| 330. | Yukiko Nishiyama, Aki Nakamoto, Akira Shigenaga and Akira Otaka : 分子内NCLを利用した環状ペプチド合成法の開発(2), 日本薬学会年会, Mar. 2009. |
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| 331. | Hiroko Hirakawa, Naomi Nishioka, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka : 光刺激応答型アミド結合切断反応のケージドセラミド創製への応用, 日本薬学会年会, Mar. 2009. |
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| 332. | Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka : 蛋白質化学合成を指向した無保護ペプチドフラグメント順次縮合法の開発, 日本薬学会年会, Mar. 2009. |
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| 333. | Hiroko Hirakawa, Naomi Nishioka, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka : 刺激応答型アミド結合切断デバイスを利用したケージドセラミドの創製, 創薬懇話会2008, Dec. 2008. |
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| 334. | Jun Yamamoto, Yoshitake Sumikawa, Naomi Nishioka, Akira Shigenaga, Toshiaki Furuta and Akira Otaka : 近赤外二光子励起応答型ペプチド結合切断デバイスの開発, 第47回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2008. |
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| 335. | Takumi Morishita, Shugo Tsuda, Nami Maeda, Akira Shigenaga and Akira Otaka : ペプチド結合切断能を有する側鎖修飾型アスパラギンの開発, 第47回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2008. |
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| 336. | Nami Maeda, Shugo Tsuda, Akira Shigenaga and Akira Otaka : N-Sアシルシフトを利用した環状ペプチドライブラリー構築の試み, 第47回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2008. |
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| 337. | Hiroko Hirakawa, Naomi Nishioka, Keiko Yamaguchi, Akira Shigenaga and Akira Otaka : 光刺激応答型アミド結合切断反応を利用したケージドセラミドの創製, 第47回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2008. |
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| 338. | Yoko Yamaki, Akira Shigenaga and Akira Otaka : 分子内redox反応を利用したフルオロアルケンジペプチドイソスターの合成, 第34回反応と合成の進歩シンポジウム, Nov. 2008. |
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| 339. | Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka : The application of peptide thioacids to NCL-type sequential condensation of peptide fragments, The 45th Japanese Peptide Symposium, Oct. 2008. |
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| 340. | Akira Shigenaga, Naomi Nishioka, Jun Yamamoto, Hiroko Hirakawa, Yoshitake Sumikawa, Keiko Yamaguchi and Akira Otaka : Influence of an amino acid sequence on kinetics of peptide bond cleavage reaction induced by a stimulus-responsive amino acid, The 45th Japanese Peptide Symposium, Oct. 2008. |
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| 341. | Yoko Yamaki, Akira Shigenaga and Akira Otaka : Synthesis of fluoroalkene dipeptide isostere utilizing intramolecular redox reaction, The 45th Japanese Peptide Symposium, Oct. 2008. |
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| 342. | Shugo Tsuda, Nami Maeda, Kiyomi Bando, Akira Shigenaga and Akira Otaka : Synthesis of peptide thioester using N-substituted aniline derivatives, The 45th Japanese Peptide Symposium, Oct. 2008. |
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| 343. | Yoshitake Sumikawa, Shugo Tsuda, Akira Shigenaga and Akira Otaka : チオカルボン酸を利用した化学的蛋白質合成法の開発に関する研究, 第24回若手化学者のための化学道場, Sep. 2008. |
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| 344. | Shugo Tsuda, Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Yoshitake Sumikawa, Kouji Itou and Akira Otaka : Development of UV irradiation-responsive amino acid with peptide bond cleavage ability and its application to a nucleocytoplasmic shuttle peptide, 第22回内藤コンファレンス, Sep. 2008. |
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| 345. | Akira Shigenaga, Naomi Nishioka, Jun Yamamoto and Akira Otaka : 任意の刺激応答型ペプチド結合切断デバイスの開発, 日本ケミカルバイオロジー研究会第3回年会, May 2008. |
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| 346. | Shugo Tsuda, Nami Maeda, Akira Shigenaga and Akira Otaka : 人工プロテインスプライシングシステムにおけるペプチド結合切断のための側鎖修飾型アスパラギンの検討, 日本薬学会年会, Mar. 2008. |
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| 347. | Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Jun Yamamoto, Shugo Tsuda, Kouji Itou and Akira Otaka : ペプチド結合切断能を有する光応答型アミノ酸の開発と核-細胞質シャトルペプチドへの応用, 日本薬学会年会, Mar. 2008. |
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| 348. | Akira Shigenaga, Daisuke Tsuji, Nishioka Naomi, Tsuda Shugo, Kouji Itou and Akira Otaka : Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application to a nucleocytoplasmic shuttle peptide, 第44回ペプチド討論会, Nov. 2007. |
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| 349. | Keiko Yamaguchi, Takashi Tsuji, Yoshikazu Sasaki, Akira Shigenaga and Akira Otaka : 有機銅試薬を用いたSN2'型アリル化反応の開発とプロリン型ジペプチドイソスターの合成, 第46回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2007. |
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| 350. | Yoko Yamaki, Yoshitake Sumikawa, Akira Shigenaga and Akira Otaka : N-ヘテロサイクリックカルベンを利用したフルオロアルケンイソスターの合成, 第46回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2007. |
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| 351. | Shugo Tsuda, Nami Maeda, Naomi Nishioka, Akira Shigenaga and Akira Otaka : 機能性ペプチドの創製を目指したアミド結合切断法の開発, 第46回日本薬学会病院薬剤師会中国四国支部学術大会, Nov. 2007. |
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| 352. | Akira Shigenaga, Daisuke Tsuji, Naomi Nishioka, Shugo Tsuda, Kouji Itou and Akira Otaka : ペプチド結合切断能を有する刺激応答型アミノ酸の開発と核-細胞質シャトルペプチドへの展開, 第33回反応と合成の進歩シンポジウム, Nov. 2007. |
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| 353. | Akira Shigenaga, Daisuke Tsuji, Shugo Tsuda, Kouji Itou and Akira Otaka : Synthesis of a nuclear-cytoplasmic shuttle peptide possessing a stimulus-responsive amino acid, 日本ケミカルバイオロジー研究会 第2回年会, May 2007. |
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| 354. | 八巻 陽子, Akira Shigenaga, 富田 健嗣, 鳴海 哲夫, 藤井 信孝 and Akira Otaka : N-ヘテロサイクリックカルベンによる分子内レドックス反応を利用したフルオロアルケンイソスターの合成, 日本薬学会年会, Mar. 2007. |
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| 355. | Akira Shigenaga, 津田 修吾 and Akira Otaka : 外部刺激応答型ペプチドプロセシングデバイスの開発, 日本薬学会年会, Mar. 2007. |
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| 356. | Akira Shigenaga, 新宅 沙織 and Akira Otaka : 外部刺激応答型ペプチドの合成と外部刺激応答能の検討, 第32回 反応と合成の進歩シンポジウム, Dec. 2006. |
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| 357. | Akira Shigenaga, 新宅 沙織 and Akira Otaka : 光刺激応答型ペプチドの開発と速度論的検討, 第7回長井長義記念シンポジウム, Sep. 2006. |
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| 358. | Akira Shigenaga and Akira Otaka : 蛋白質機能の時空間的制御を目指した外部刺激応答型ペプチドの開発, 日本薬学会年会, Mar. 2006. |
| 1. | Tsuyoshi Tahara, Chiho Shonozaki, Tetsuro Yoshimaru, 毛利 浩太, Masaya Denda, Tamaki Otani, Toyomasa Katagiri, Akira Otaka, 向井 英史 and 崔 翼龍 : Kinetic analysis for lapidated anti-cancer peptides using PET, 日本分子イメージング学会, May 2024. |
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| 2. | Kazuya Iwamoto, Tsubasa Inokuma, Ken Sakamoto, Kohei Sato, Akira Shigenaga and Akira Otaka : NCL法を利用したペプチド–タンパク質コンジュゲーション法の開発研究, 第6回夏の生物系勉強会, Aug. 2015. |
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| 3. | Chiaki Komiya, Tsubasa Inokuma, Akira Shigenaga and Akira Otaka : タンパク質機能の時空間的制御を指向したペプチド結合切断能を有する刺激応答型アミノ酸の開発, 文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第10回 若手スクール, May 2014. |
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| 4. | Akira Shigenaga and Akira Otaka : Development of traceable linker for target identification using N-sulfanylethylanilide unit, The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity, Oct. 2013. |
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| 5. | Keisuke Aihara, Akira Shigenaga, Kohei Tsuji, Kohei Sato and Akira Otaka : タンパク質化学合成を指向した多成分ペプチドフラグメント縮合法の開発, 文部科学省科学研究費補助金 新学術領域研究「融合マテリアル」第5回若手スクール, Nov. 2012. |
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| 6. | Akira Shigenaga, Jun Yamamoto, Nami Maeda, Youichi Sato, Aiko Yamauchi and Akira Otaka : 標的タンパク質の精製およびラベル化を可能とするトレーサブルリンカーの開発, 新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」第2回若手研究者ワークショップ, Oct. 2012. |
|
| 7. | Kohei Sato, Akira Shigenaga and Akira Otaka : Native chemical ligation (NCL) without using peptide thioester, 14th Peptide Forum, Dec. 2011. |
|
| 8. | Kohei Tsuji, Yoshitake Sumikawa, Akira Shigenaga and Akira Otaka : Diversity-oriented Synthesis of CXCL14 and Its Derivatives, The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010. |
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| 9. | Kohei Sato, Shugo Tsuda, Yoshitake Sumikawa, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka : Native chemical ligation utilizing N-peptidyl anilide auxiliary, The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010. |
|
| 10. | Keiji Ogura, Hiroko Hirakawa, Akira Shigenaga and Akira Otaka : Synthesis of nonhydrolyzable AMPylated amino acid mimetics for revealing physiological role of AMPylated protein, The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010. |
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| 11. | Jun Yamamoto, Nami Maeda, Masaya Denda, Akira Shigenaga and Akira Otaka : Design and synthesis of recapturable cleavable linker for efficient enrichment and specific labeling of target proteins, The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010. |
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| 12. | Ko Morishita, Keiko Yamaguchi, Hao Ding, Akira Shigenaga and Akira Otaka : Development of stimulus responsive thiol releasing device for controlling activity of cysteine protease, The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010. |
|
| 13. | Akira Shigenaga and Akira Otaka : Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application for controlling peptidyl function, The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences, Dec. 2010. |
|
| 14. | Akira Shigenaga and Akira Otaka : 刺激応答型アミノ酸の開発とペプチド機能制御への展開, 第6回HBS月例セミナー, Oct. 2009. |