Tokushima University / Educator and Researcher Directory --- Tominaga, Masahide

Field of Study

○	Medicine

Subject of Study

○

Book / Paper

Book:

1.	Motoharu Sasaki and Masahide Tominaga : 外部光子線の線量計算 ---放射線治療技術学 ---, KYORITSU SHUPPAN.CO.,LTD, Tokyo, Dec. 2024.
2.	Masahide Tominaga and Motoharu Sasaki : 脳・体幹部定位照射 --- 図解診療放射線技術実践ガイド第4版 ---, 文光堂, Tokyo, Feb. 2020.
3.	Yoshihiro Uto, Chiaki Abe, Mana Futawaka, Hisatsugu Yamada, Masahide Tominaga and Yoshio Endo : In vivo drug screening method of radiosensitizers using tumor-bearing chick embryo, Elsevier, Oct. 2019. (Summary) In radiotherapy, tumor hypoxia is the main factor responsible for treatment resistance, and the development of radiosensitizers that can overcome this is imperative. However, many drugs that are effective in vitro and in vivo fail in clinical trials, and thus it is necessary to develop an animal model that can be used for the correct evaluation of pharmacokinetics and activity. Developing chicken eggs are commonly used in various research fields such as anticancer drug sensitivity tests and cardiotoxicity tests. We examined whether the radiosensitizing activity of etanidazole, as a hypoxic cell radiosensitizer, could be evaluated using tumor-bearing chick embryo. Following the transplantation of mouse mammary carcinoma EMT6 cells on day 11, a solid tumor was formed on day 15 and an evaluation of the time-course of the tumor revealed that the tumor weight was the highest on day 18. The maximum dose of etanidazole that did not affect tumor growth and fetal survival was 1.0mg and the maximum X-ray dose was 8Gy. Etanidazole was intravenously administered 10min prior to single dose X-ray irradiation. A significant tumor growth inhibitory effect was confirmed with 1.0mg of etanidazole in combination with 8Gy X-ray. In the case of mouse colon cancer colon26 cells, the combination of 3.0mg of etanidazole and 2Gy X-ray showed 2.79 times higher radiosensitizing activity than that observed for the control group. These results demonstrate that it is possible to evaluate the activity of radiosensitizers using tumor-bearing chick embryo. (Keyword) Etanidazole / Hypoxic cell radiosensitizer / Mouse colon cancer colon26 cell / Mouse mammary carcinoma EMT6 cell / Tumor-bearing chick embryo (Link to Publication Site) ● Publication site (DOI): 10.1016/bs.enz.2019.08.008 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31727273 ● Search Scopus @ Elsevier (PMID): 31727273 ● Search Scopus @ Elsevier (DOI): 10.1016/bs.enz.2019.08.008 (DOI: 10.1016/bs.enz.2019.08.008, PubMed: 31727273)
4.	Masahide Tominaga : 幾何学的管理項目, ピラールプレス, Jul. 2013.

Academic Paper (Judged Full Paper):

1.	Motoharu Sasaki, Yuji Nakaguchi, Takeshi Kamomae, Akira Tsuzuki, Sohma Sawada, Kohki Shibuya, Masataka Oita, Masahide Tominaga, Yuki Tominaga and Hitoshi Ikushima : Comparative analysis of two dose-volume histogram prediction tools for treatment planning in volumetric-modulated arc therapy: A multi-planner study, Medical Dosimetry, Vol.49, No.3, 271-275, 2024. (Summary) The increase in high-precision radiation therapy, particularly volumetric-modulated arc therapy (VMAT), has increased patient numbers and expanded treatment sites. However, a significant challenge in VMAT treatment planning is the inconsistent plan quality among different planners and facilities. This study explored the use of dose-volume histogram (DVH) prediction tools to address these disparities, specifically focusing on RapidPlan (Varian Medical Systems) and PlanIQ (Sun Nuclear). RapidPlan predicts achievable DVHs and automatically generates optimization objectives. While it has demonstrated organ-at-risk (OAR) dose reduction benefits, the quality of the plan used to build its model significantly affects its predictions. On the other hand, PlanIQ offers ease of use and does not require prior model-building. Five planners participated in this study, each creating two treatment plans: one referencing RapidPlan and the other using PlanIQ. The planners had the freedom to adjust parameters while referencing the DVH predictions. The plans were evaluated using "Plan Quality Metric" (PQM) scores to assess the planning target volume excluding the rectum and OARs. The results revealed that RapidPlan-referenced plans often outperformed PlanIQ-based plans, with less interplanner variability. PlanIQ played a pivotal role in the construction of the RapidPlan model. This study is the first to compare plans generated by multiple planners using both tools. This study provides insights into optimizing treatment planning by considering the characteristics of both RapidPlan and PlanIQ. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.meddos.2024.02.002 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38556402 ● Search Scopus @ Elsevier (PMID): 38556402 ● Search Scopus @ Elsevier (DOI): 10.1016/j.meddos.2024.02.002 (DOI: 10.1016/j.meddos.2024.02.002, PubMed: 38556402)
2.	IKEDA Hinata, Hiroyuki Ukida, Koki Yamazoe, Masahide Tominaga, Tomoyo Sasao and Kenji Terada : 3D shape reconstruction of Japanese traditional puppet head from CT images by graph cut and machine learning methods, SICE Journal of Control, Measurement, and System Integration, Vol.16, No.1, 117-139, 2023. (Tokushima University Institutional Repository) ● Metadata: 119576 (Link to Publication Site) ● Publication site (DOI): 10.1080/18824889.2023.2185929 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1080/18824889.2023.2185929 (Tokushima University Institutional Repository: 119576, DOI: 10.1080/18824889.2023.2185929)
3.	Kenji Yamada, Yoshiki Kawata, Masafumi Amano, Hidenobu Suzuki, Masahide Tominaga, Motoharu Sasaki, Hikaru Nishiyama, Masafumi Harada and Noboru Niki : Influence of Pitch on Surface Dose Distribution and Image Noise of Computed Tomography Scans, Sensors, Vol.23, No.7, 3472, 2023. (Summary) This study evaluated the effect of pitch on 256-slice helical computed tomography (CT) scans. Cylindrical water phantoms (CWP) were measured using axial and helical scans with various pitch values. The surface dose distributions of CWP were measured, and reconstructed images were obtained using filtered back-projection (FBP) and iterative model reconstruction (IMR). The image noise in each reconstructed image was decomposed into a baseline component and another component that varied along the z-axis. The baseline component of the image noise was highest at the center of the reconstructed image and decreased toward the edges. The normalized 2D power spectra for each pitch were almost identically distributed. Furthermore, the ratios of the 2D power spectra for IMR and FBP at different pitch values were obtained. The magnitudes of the components varying along the z-axis were smallest at the center of the reconstructed image and increased toward the edge. The ratios of the 3D power spectra on the fx axis for IMR and FBP at different pitch values were obtained. The results showed that the effect of the pitch was related to the component that varied along the z-axis. Furthermore, the pitch had a smaller effect on IMR than on FBP. (Keyword) Helical computed tomography / Pitch / Surface dose distribution / FBP / IMR / Image noise / Power spectrum (Tokushima University Institutional Repository) ● Metadata: 119404 (Link to Publication Site) ● Publication site (DOI): 10.3390/s23073472 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.3390/s23073472 (Tokushima University Institutional Repository: 119404, DOI: 10.3390/s23073472)
4.	Hiroyuki Ukida, Koki Yamazoe, Masahide Tominaga, Tomoyo Sasao and Kenji Terada : 3D Shape Reconstruction of Japanese Traditional Puppet Head from CT images, Frontiers of Computer Vision, 49-63, 2022. (Tokushima University Institutional Repository) ● Metadata: 118059 (Link to Publication Site) ● Publication site (DOI): 10.1007/978-3-031-06381-7_4 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85131138428 (Tokushima University Institutional Repository: 118059, DOI: 10.1007/978-3-031-06381-7_4, Elsevier: Scopus)
5.	Hiroki Inata, Masahide Tominaga, Motoharu Sasaki, Yuta Kuribayashi, Noritaka Sodeoka, Azusa Katakami and Osamu Nishizaki : Estimation of imaging intervals and intra-fraction displacement in CyberKnife image-guided radiotherapy for intracranial lesions, Medical Physics, Vol.48, No.12, 7580-7589, 2021. (Keyword) imaging interval / intra-fraction / internal margin / IGRT / CyberKnife (Link to Publication Site) ● Publication site (DOI): 10.1002/mp.15169 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/mp.15169 (DOI: 10.1002/mp.15169)
6.	Masahide Tominaga, Yukari Nagayasu, Motoharu Sasaki, Furuta Takuya, Hiroaki Hayashi, Masataka Oita, Yuichi Nishiyama and Akihiro Haga : Influence of distant scatterer on air kerma measurement in the evaluation of diagnostic X-rays using Monte Carlo simulation, Radiological Physics and Technology, Vol.14, No.4, 381-389, 2021. (Summary) The evaluation of the entrance surface dose (ESD) ensures safe radiation doses for X-ray imaging patients. The air kerma free-in-air value used to estimate ESD may be affected by those X-rays that scatter from the scatterer placed behind the chamber at the time of measurement, thereby leading to assessment errors. Therefore, the influence of scattered radiation on air kerma measurements was investigated. Monte Carlo simulations were performed for various detector-to-scatterer distances and scatterer materials. The simulation results were compared with actual measurements to confirm the simulation accuracy. The source-chamber distance was set to 50 and 100 cm for the experimental measurements and simulation, respectively, and the chamber-scatterer distance was varied. The Monte Carlo simulation results reproduced the actual measurements with an accuracy of 3.5%. The effect of backscattering varied with the tube voltage and irradiation field size. The effect was observed in the order of prominence for the following scatterer materials: water-equivalent phantom, acrylic, concrete, lead, and iron. Furthermore, this effect decreased exponentially with increasing chamber-scatterer distance. For a field size of 10 × 10 cm, the finite-distance backscatter factor decreased with an increasing chamber-scatterer distance for all materials. The cause of backscattering in diagnostic X-ray energy regions differs depending on the scatterer material, as well as the photon energy and field size. Backscattering decreases exponentially as the distance between the detector and scatterer increases. (Keyword) Air kerma / Backscattering / Dosimetry / Monte Carlo simulation (Link to Publication Site) ● Publication site (DOI): 10.1007/s12194-021-00641-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34716568 ● Search Scopus @ Elsevier (PMID): 34716568 ● Search Scopus @ Elsevier (DOI): 10.1007/s12194-021-00641-3 (DOI: 10.1007/s12194-021-00641-3, PubMed: 34716568)
7.	Hirofumi Honda, Masahide Tominaga, Motoharu Sasaki, Masataka Oita, Kanzaki Hiromitsu, Hamamoto Yasushi, Ishii Yoshiaki, Yamamoto Ryuji, Mochizuki Teruhito, Kido Teruhito and Yoshihiro Uto : Usability of detecting delivery errors during treatment of prostate VMAT with a gantry-mounted transmission detector, Journal of Applied Clinical Medical Physics, Vol.22, No.7, 66-76, 2021. (Summary) Volumetric-modulated arc therapy (VMAT) requires highly accurate control of multileaf collimator (MLC) movement, rotation speed of linear accelerator gantry, and monitor units during irradiation. Pretreatment validation and monitoring of these factors during irradiation are necessary for appropriate VMAT treatment. Recently, a gantry mounted transmission detector "Delta Discover® (D4D)" was developed to detect errors in delivering doses and dose distribution immediately after treatment. In this study, the performance of D4D was evaluated. Simulation plans, in which the MLC position was displaced by 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 mm from the clinically used original plans, were created for ten patients who received VMAT treatment for prostate cancer. Dose deviation (DD), distance-to-agreement (DTA), and gamma index analysis (GA) for each plan were evaluated by D4D. These results were compared to the results (DD, DTA and GA) measured by Delta Phantom + (D4P). We compared the deviations between the planned and measured values of the MLC stop positions A-side and B-side in five clinical cases of prostate VMAT during treatment and measured the GA values. For D4D, when the acceptable errors for DD, DTA, and GA were determined to be ≤3%, ≤2 mm, and ≤3%/2 mm, respectively, the minimum detectable errors in the MLC position were 2.0, 1.5, and 1.5 mm based on DD, DTA, and GA respectively. The corresponding minimum detectable MLC position errors were 2.0, 1.0, and 1.5 mm, respectively, for D4P. The deviation between the planned and measured position of MLC stopping point of prostate VMAT during treatment was stable at an average of -0.09 ± 0.05 mm, and all GA values were above 99.86%. In terms of delivering doses and dose distribution of VMAT, error detectability of D4D was comparable to that of D4P. The transmission-type detector "D4D" is thus suitable for detecting delivery errors during irradiation. (Keyword) in vivo dosimetry / transmission detector / three-dimensional dose verification system / volume-modulated arc therapy (Tokushima University Institutional Repository) ● Metadata: 116183 (Link to Publication Site) ● Publication site (DOI): 10.1002/acm2.13260 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33955161 ● Search Scopus @ Elsevier (PMID): 33955161 ● Search Scopus @ Elsevier (DOI): 10.1002/acm2.13260 (Tokushima University Institutional Repository: 116183, DOI: 10.1002/acm2.13260, PubMed: 33955161)
8.	Hasegawa Yu, Akihiro Haga, Sakata Dousatsu, Yuki Kanazawa, Masahide Tominaga, Motoharu Sasaki, Imae Toshikazu and Nakagawa Keiichi : Estimation of X-ray Energy Spectrum of Cone-Beam Computed Tomography Scanner Using Percentage Depth Dose Measurements and Machine Learning Approach, Journal of the Physical Society of Japan, Vol.90, 074801-1-074801-7, 2021. (Link to Publication Site) ● Publication site (DOI): 10.7566/JPSJ.90.074801 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.7566/JPSJ.90.074801 (DOI: 10.7566/JPSJ.90.074801)
9.	Yuichi Nishiyama, Akinori Morita, Bing Wang, Takuma Sakai, Dwi Ramadhani, Kaoru Tanaka, Megumi Sasatani, Shintaro Ochi, Masahide Tominaga, Hitoshi Ikushima, Junji Ueno, Mitsuru Nenoi and Shin Aoki : Evaluation of sodium orthovanadate as a radioprotective agent under total-body irradiation and partial-body irradiation conditions in mice., International Journal of Radiation Biology, Vol.97, No.9, 1241-1251, 2021. (Tokushima University Institutional Repository) ● Metadata: 116409 (Link to Publication Site) ● Publication site (DOI): 10.1080/09553002.2021.1941377 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34125648 ● Search Scopus @ Elsevier (PMID): 34125648 ● Search Scopus @ Elsevier (DOI): 10.1080/09553002.2021.1941377 (Tokushima University Institutional Repository: 116409, DOI: 10.1080/09553002.2021.1941377, PubMed: 34125648)
10.	Hirari Yamahana, Yukari Kunieda, Masahide Tominaga, Hisatsugu Yamada and Yoshihiro Uto : Development of a novel acetyl glucose-modified gefitinib derivative to enhance the radiosensitizing effect, Bioorganic & Medicinal Chemistry, Vol.29, 115889, 2021. (Summary) Various radiosensitizers are being developed to increase the radiation sensitivity of hypoxic cancer cells, which show resistance to radiation. Previously, we demonstrated that an acetyl glucose-modified nitroimidazole derivative showed a high radiosensitizing effect by inhibiting glucose uptake and glycolysis. Based on this finding, we designed and synthesized novel sugar hybrid radiosensitizers, wherein acetyl glucose was introduced into gefitinib. Among them, UTX-114 had higher autophosphorylation and radiosensitizing activity than gefitinib and inhibited glucose uptake. This result supports our hypothesis that an acetyl glucose moiety improves the radiosensitizing effect of the drug, and UTX-114 can be expected to be a leading compound with a radiosensitizing effect. (Keyword) EGFR / GLUT / Gefitinib / Radiosensitizer / Sugar-hybrids (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bmc.2020.115889 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33260051 ● Search Scopus @ Elsevier (PMID): 33260051 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2020.115889 (DOI: 10.1016/j.bmc.2020.115889, PubMed: 33260051)
11.	Tumenjin Enkhbat, Masaaki Nishi, Kouzou Yoshikawa, Jun Higashijima, Takuya Tokunaga, Chie Takasu, Hideya Kashihara, Daichi Ishikawa, Masahide Tominaga and Mitsuo Shimada : Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy., Anticancer Research, Vol.38, No.11, 6247-6252, 2018. (Summary) Epigallocatechin-3-gallate (EGCG) is a major polyphenolic component of green tea. EGCG plays a potential role in radio-sensitizing cancer cells. The combined effect of EGCG and radiation was investigated in a colorectal cancer cell line, focusing on nuclear factor (erythroid-derived 2)-like 2 (Nrf2) autophagy signalling. HCT-116 cells were treated with 12.5 μM EGCG for different periods of time, 2 Gy radiation, or both. Cell viability was determined with the WST-8 assay. The number of colonies was determined with the colony formation assay. mRNA expression of LC3 and caspase-9 was analyzed with quantitative real-time polymerase chain reaction. Combination treatment with EGCG and radiation significantly decreased the growth of HCT-116 cells. The number of colonies was reduced to 34.2% compared to the control group. Immunofluorescence microscopy images showed that nuclear translocation of Nrf2 was significantly increased when cells were treated with the combination of EGCG and radiation compared to the control and single-treatment groups. Combined treatment with EGCG and radiation significantly induced LC3 and caspase-9 mRNA expression. EGCG increased the sensitivity of colorectal cancer cells to radiation by inhibiting cell proliferation and inducing Nrf2 nuclear translocation and autophagy. (Keyword) Caspase 9 / Catechin / Cell Nucleus / Cell Proliferation / Cell Survival / Colorectal Neoplasms / Gene Expression Regulation, Neoplastic / HCT116 Cells / Humans / Microtubule-Associated Proteins / NF-E2-Related Factor 2 / Protein Transport / Radiation-Sensitizing Agents / Transcriptional Activation (Tokushima University Institutional Repository) ● Metadata: 113340 (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.12980 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30396944 ● Summary page in Scopus @ Elsevier: 2-s2.0-85056084372 (Tokushima University Institutional Repository: 113340, DOI: 10.21873/anticanres.12980, PubMed: 30396944, Elsevier: Scopus)
12.	Tomoko Kaneko, Masahide Tominaga, Risa Kouzaki, Ayaka Hanyu, Kazuki Ueshima, Hisatsugu Yamada, Masaki Suga, Tomohiro Yamashita, Tomoaki Okimoto and Yoshihiro Uto : Radiosensitizing Effect of 5-Aminolevulinic Acid and Protoporphyrin IX on Carbon-ion Beam Irradiation, Anticancer Research, Vol.38, No.7, 4313-4317, 2018. (Summary) Carbon-ion beam is one of the most advanced radiations used for cancer treatment. However, there are tumors that are difficult to suppress with carbon-ion beam alone, thus necessitating development of drugs that can enhance its therapeutic effect. In this regard, the radiosensitizing effect of 5-aminolevulinic acid (ALA) and protoporphyrin IX (PpIX), that is a metabolic intermediate of ALA, on carbon-ion beam was investigated. Radiosensitizing activity, mitochondrial ROS and DNA double-strand break production of ALA and PpIX were evaluated by irradiation with 1.0 or 1.5-Gy carbon-ion beam to mouse mammary EMT6 tumor cells. Combination of carbon-ion beam and ALA or PpIX showed a significant enhancement of its cytotoxic activity through a significant increase in ROS production in mitochondria. Furthermore, the combined activity of carbon-ion beam and ALA resulted in a significant increase in DNA double-strand breakage. ALA selectively accumulates in the mitochondria and PpIX synthesized from ALA reacts with carbon-ion beam to produce ROS that exert antitumor activity. (Keyword) 5-Aminolevulinic acid / carbon-ion beam / mitochondria / protoporphyrin IX / reactive oxygen species (Link to Publication Site) ● Publication site (DOI): 10.21873/anticanres.12730 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29970567 ● Summary page in Scopus @ Elsevier: 2-s2.0-85049771897 (DOI: 10.21873/anticanres.12730, PubMed: 29970567, Elsevier: Scopus)
13.	Yusei Shinohara, Yoshio Endo, Chiaki Abe, Ikkyu Shiba, Masahiro Ishizuka, Tohru Tanaka, Yutaka Yonemura, Syunichiro Ogura, Masahide Tominaga, Hisatsugu Yamada and Yoshihiro Uto : Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy., Photodiagnosis and Photodynamic Therapy, Vol.20, 182-188, 2017. (Summary) 5-Aminolevulinic acid (ALA), a precursor of protoporphyrin IX (PpIX), is now widely used for photodynamic diagnosis (ALA-PDD) and photodynamic therapy (ALA-PDT) of various cancers. Recently, we found that treatment of cancer cells with the Schiff base derivative TX-816 along with ALA could significantly increase the efficacy of ALA-PDT. This enhancing effect of TX-816 on ALA-PDT is attributed to 3,5-dichlorosalicylaldehyde (DCSA), a molecule produced by the degradation of TX-816. Similar to TX-816, DCSA significantly enhances the effect of ALA-PDT. Furthermore, DCSA could restore the sensitivity of cancer cells that acquired resistance to ALA-PDT. These results indicate that DCSA, as well as TX-816, is a potent lead compound for the development of an ALA-PDT sensitizer. TX-816 might be a useful compound for designing prodrug-type ALA-PDT enhancers. (Keyword) 5-Aminolevulinic acid / Photodynamic therapy / Protoporphyrin IX / Schiff base (Link to Publication Site) ● Publication site (DOI): 10.1016/j.pdpdt.2017.10.014 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29056554 ● Summary page in Scopus @ Elsevier: 2-s2.0-85032287431 (DOI: 10.1016/j.pdpdt.2017.10.014, PubMed: 29056554, Elsevier: Scopus)
14.	Yusei Shinohara, Yoshio Endo, Chiaki Abe, Ikkyu Shiba, Masahiro Ishizuka, Tohru Tanaka, Yutaka Yonemura, Shun-Ichiro Ogura, Masahide Tominaga, Hisatsugu Yamada and Yoshihiro Uto : Development of a novel Schiff base derivative for enhancing the anticancer potential of 5-aminolevulinic acid-based photodynamic therapy, Photodiagnosis and Photodynamic Therapy, Vol.20, 182-188, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.pdpdt.2017.10.014 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85032287431 (DOI: 10.1016/j.pdpdt.2017.10.014, Elsevier: Scopus)
15.	Motoharu Sasaki, Masahide Tominaga, Kamomae Takeshi, Hitoshi Ikushima, Kitaoka Motonori, Bando Ryota, Kanako Sakuragawa and Masataka Oita : Influence of multi-leaf collimator leaf transmission on head and neck intensity-modulated radiation therapy and volumetric-modulated arc therapy planning., Japanese Journal of Radiology, Vol.35, No.9, 511-525, 2017. (Summary) The aim of this study was to quantify the effect of multi-leaf collimators (MLCs) with different leaf widths on the planning of intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT). Toward this objective, dose transmission through a high-definition 120-leaf MLC (HD120MLC) and 120-leaf Millennium MLC (M120MLC) was investigated, using it with a test case and clinical case studies. In test case, studies with IMRT and VMAT plans, the difference in MLC leaf width had a limited effect on planning target volumes (PTVs). Organs at risk (OARs) were more affected by a reduction in dose transmission through the MLC than by a reduction in MLC leaf width. The results of the test case studies and clinical case studies were mostly similar. In the latter, the different MLCs had no effect on the PTV regardless of the treatment method; however, the HD120MLC plans achieved dose reductions to OARs similar to or larger than the dose reduction of the M120MLC plans. The similar results of the test case and clinical case studies showed that despite a limitation of the irradiation field size, the HD120MLC plans were superior. (Link to Publication Site) ● Publication site (DOI): 10.1007/s11604-017-0661-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28647834 ● Summary page in Scopus @ Elsevier: 2-s2.0-85021229873 (DOI: 10.1007/s11604-017-0661-8, PubMed: 28647834, Elsevier: Scopus)
16.	Masahide Tominaga, Hiroaki Hayashi, Akinori Matsumoto, Natsumi Kimoto, Okazaki Tohru, Hashizume Takuya and Kobayashi Ikuo : Uncertainty evaluation of absorbed dose measurements by means of small-type OSL dosimeter for radiotherapeutic X-ray region, Medical Imaging and Information Sciences, Vol.33, No.2, 32-37, 2016. (Summary) For Quality Assurance of clinical radiation therapy, it is necessary to accurately measure multiple doses, and evaluate and compare the results to the radiation treatment system. Based on the measurements using multiple dosimeters, there is no uncertainty estimation of the delivered dose for accurate analysis. In this study, we focused attention on small-type optically stimulated luminescence (OSL) dosimeters, and clarified the relationship of uncertainties between the experimental variance associated with multiple data points and the variance predicted by Poisson distribution. The experiments were carried out as follows: fifteen dosimeters were placed in a water equivalent phantom, they were irradiated with X-rays having an acceleration voltage of 10-MV with 167.2 cGy (200 MU) and 2,090 cGy (2,500 MU). Each dosimeter was read ten times and the experimental variance and predicted variance were analyzed. As a result, we found that the experimental uncertainties were 3.9 and 6.2 times higher than predicted uncertainty when irradiated at 167.2 cGy and 2,090 cGy, respectively. We discuss the relationship of measurement uncertainties. Then, we concluded that the uncertainty of OSL dosimeters was found to be 3%. We also conclude that the OSL dosimeter can be used to measure the absorbed dose in the radiation therapy region. (Keyword) OSL dosimeter / radiation therapy (Link to Publication Site) ● Publication site (DOI): 10.11318/mii.33.32 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11318/mii.33.32 (DOI: 10.11318/mii.33.32)
17.	Tomoko Kaneko, Masahide Tominaga, Yoshio Endo, Kazunori Yaju, Risa Kouzaki, Hisatsugu Yamada, Ikuo Nakanishi, Kenichiro Mastumoto and Yoshihiro Uto : RADIOSENSITIZING EFFECT OF PROTOPORPHYRIN IX WITH CARBON ION BEAM AGAINST MOUSE MAMMARY BREAST TUMOR CELL., Journal of Advanced Manufacturing Technology, 47-51, 2016. (Summary) 5-Aminolevulinic acid (ALA), a precursor ofprotoporphyrin IX (PpIX), has been utilized as a potent sensitizerfor photodynamic therapy (PDT) of cancer through productionof reactive oxygen species (ROS). ALA also has been proposed asa possible radiosensitizer with low linear energy transfer (LET)radiation because antitumor activity of low-LET radiation dependson ROS mainly. In this paper, we investigated the radiosensitizingactivity of PpIX in carbon ion irradiation as a high LET radiation.PpIX was detected in an EMT6 mouse mammary breast tumor cellseven at 24 h post treatment. The cytotoxicity of PpIX against EMT6cells was IC50 = 48.0 m. The combined treatment of 1.0 m of PpIXwith 2 Gy of carbon ion irradiation (290 MeV/nucleon, 85.1 keV/m)showed a more potent antitumor activity than carbon ion irradiationalone. We demonstrated that PpIX showed a radiosensitizing effectwith carbon ion beam against mouse mammary breast tumor cells. (Keyword) Carbon Ion Beam / Protoporphyrin IX / Aminolevulinic Acid / Radiosensitization
18.	Itsumi Maehata, Hiroaki Hayashi, Natsumi Kimoto, Kazuki Takegami, Hiroki Okino, Yuki Kanazawa and Masahide Tominaga : Practical method for determination of air-kerma by using an ionization chamber toward the construction of secondary X-ray field to be used in clinical examination rooms, Radiological Physics and Technology, Vol.9, No.2, 193-201, 2016. (Tokushima University Institutional Repository) ● Metadata: 110812 (Link to Publication Site) ● Publication site (DOI): 10.1007/s12194-016-0352-7 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1007/s12194-016-0352-7 (Tokushima University Institutional Repository: 110812, DOI: 10.1007/s12194-016-0352-7)
19.	Motoharu Sasaki, Hitoshi Ikushima, Masahide Tominaga, T Kamomae, T Kishi, Masataka Oita and Masafumi Harada : Dose impact of rectal gas on prostatic IMRT and VMAT, Japanese Journal of Radiology, Vol.33, No.12, 723-733, 2015. (Summary) In this study, we compared the dose impact of the heterogeneity caused by rectal gas using two methods of treatment planning for intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT). In addition to the structure set used for the standard treatment plan, we created a structure set for evaluation for each patient. These sets were transferred to the same isocenter as the respective treatment plans for IMRT and VMAT that were to become the standard. Values were then recalculated. During the standard prostatic IMRT and VMAT treatment planning, all study participants met dose restrictions in place at our hospital. Dose restrictions were fulfilled in treatment plans for evaluation, excluding those with a clinical target volume (CTV) of V(100%) and planning target volume (PTV) of D95 when the rectum was excluded. However, in treatment plans for evaluation, IMRT was shown to have a higher concordance rate with standard treatment plans than VMAT. If rectal gas is present during either IMRT or VMAT, a dose decrease will occur in relation to CTV and PTV, suggesting that a plan does not eliminate adverse effects on organs at risk. (Tokushima University Institutional Repository) ● Metadata: 109667 (Link to Publication Site) ● Publication site (DOI): 10.1007/s11604-015-0481-7 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26573828 ● Search Scopus @ Elsevier (PMID): 26573828 ● Search Scopus @ Elsevier (DOI): 10.1007/s11604-015-0481-7 (Tokushima University Institutional Repository: 109667, DOI: 10.1007/s11604-015-0481-7, PubMed: 26573828)
20.	Masataka Oita, Yoshihiro Uto, Masahide Tominaga, Motoharu Sasaki, Yasuo Hara, Taro Kishi and Hitoshi Hori : Radiosensitivity Uncertainty Evaluation for the In Vitro Biophysical Modeling of EMT6 Cells, Anticancer Research, Vol.34, No.8, 4621-4626, 2014. (Summary) The aims of this study were to evaluate the cell survival uncertainty distribution of radiation and to assess the accuracy of predictions of tumor response by using three different in vitro experimental cell cultures with radiosensitizers (including etanidazole). Using EMT6 cells and X-rays, the cell survival fraction was obtained from 15, 34, and 21 different experiments under normoxic, hypoxic, and hypoxic-plus-radiosensitizer culture, respectively. The α coefficients were 0.257 ± 0.188, 0.078 ± 0.080, and 0.182 ± 0.116 Gy(-1), respectively. The β coefficients were 0.0159 ± 0.0208, 0.0076 ± 0.0113, and 0.0062 ± 0.0077 Gy(-2), respectively. The α coefficient and the dose that killed half of the clonogens population (D50) were significantly different between normoxic cell and hypoxic cell cultures (p<0.01), respectively. The use of radiosensitizers under hypoxic conditions improved radiosensitivity. Our results suggest that parameter value distributions are required for biophysical modeling of applications for radiotherapy. (Keyword) Radiotherapy / biophysical modelling / in vitro / radiosensitivity uncertainty (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25075109 ● Search Scopus @ Elsevier (PMID): 25075109 (PubMed: 25075109)
21.	Motoharu Sasaki, Masahide Tominaga, t Kamomae, Hitoshi Ikushima, T Kishi, T Kawashita, A Tada, M Shigemitsu and Masataka Oita : Clinical evaluation of automatic contours for head and neck region using deformable image registration software, Japanese Journal of Radiological Technology, Vol.69, No.11, 1250-1260, 2013. (Summary) The purpose of this study was to clinically evaluate the automatic outline extraction properties using general-purpose deformable image registration (DIR) software for the head and neck region. To this end, we evaluated the following: (1) the difference between manual outline extraction carried out by a radiation therapy specialist and automatic outline extraction using the DIR software, and (2) the precision of the automatic outline extraction for the diachronic figure change and change in the organ shape. The manually-extracted outline and that extracted using the DIR software closely resembled each other at 0.70. Further, in the same case, the automatic outline extraction precision of the DIR software was greater at about 0.80. Our findings suggest DIR software to be useful for lessening the work involved in outline extraction. (Keyword) deformable image registration (DIR) / auto-segmentation / head and neck (Link to Publication Site) ● Publication site (DOI): 10.6009/jjrt.2013_JSRT_69.11.1250 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24256648 ● CiNii @ National Institute of Informatics (CRID): 1390001206363278720 ● Summary page in Scopus @ Elsevier: 2-s2.0-84896689742 (DOI: 10.6009/jjrt.2013_JSRT_69.11.1250, PubMed: 24256648, CiNii: 1390001206363278720, Elsevier: Scopus)
22.	Bado Ryota, Hitoshi Ikushima, Takashi Kawanaka, Takaharu Kudoh, Motoharu Sasaki, Masahide Tominaga, Taro Kishi, Shunsuke Furutani, Akiko Kubo and Koichi Tamura : Changes of tumor and normal structures of the neck during radiation therapy for head and neck cancer requires adaptive strategy., The Journal of Medical Investigation : JMI, Vol.60, No.1,2, 46-51, 2013. (Summary) The treatment period over which radiation therapy is administered extends over several weeks. Since tumor shrinkage in response to radiation therapy and weight loss due to radiation-induced mucositis may impact on the dose distribution in both target and organ at risk in patients with head and neck cancer, the anatomical changes of tumor and neck volumes during this period should be taken into consideration. We investigated the anatomical changes that occurred in the target and normal structure of the neck during radiation therapy for pharyngeal cancer, and evaluated the necessity of an adaptive strategy. Ten patients with pharyngeal cancer who underwent radical chemoradiation therapy using 3-dimensional conformal radiation therapy RT (66-70 Gy in 33-35 fractions) between April 2009 and September 2010 were enrolled in the study. Patients underwent CT scans every week during their course of treatment. We analyzed the CT data in the radiation treatment planning system and measured changes of tumor, organ at risk, and neck volume. Gross tumor volume (GTV) was rapidly reduced by 28% of the original volume on average in the first 3 weeks. The right and left submandibular glands volume decreased to 70% and 63% of their initial volumes on average, respectively. The volume of the neck in the radiation fields decreased to 89% of its initial volume on average by the sixth week mainly caused by body weight loss due to acute radiation morbidity. Considerable anatomical change in the radiation filed that will affect dose distribution of the target and organ at risk was observed during radiation therapy for head and neck cancer. (Keyword) adaptive strategy / chemoradiotherapy / head and neck cancer (Tokushima University Institutional Repository) ● Metadata: 106041 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.60.46 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23614911 ● Search Scopus @ Elsevier (PMID): 23614911 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.60.46 (Tokushima University Institutional Repository: 106041, DOI: 10.2152/jmi.60.46, PubMed: 23614911)
23.	Hiroaki Hayashi, 谷内翔, 神谷尚武, Sadamitsu Nishihara and Masahide Tominaga : Development of a pin-hole camera using a phosphor plate, and visualization of the scattered X-ray distribution and optical image, Japanese Journal of Radiological Technology, Vol.68, No.3, 307-311, 2012. (Summary) In order to obtain an image of scattered X-ray in the diagnosis domain, we have newly developed a pin-hole camera. Because of the necessity of the X-ray shielding, the pin-hole part has a depth corresponding to that of the shielded material. As a result, efficiencies of obliquely incident X-rays are reduced. To decrease the descent of the efficiencies, we developed a large camera using a 10×12 inch size phosphor plate as an X-ray detector. A phantom was irradiated by X-rays with conditions of 500 mAs and 5000 mAs, and images of scattered X-rays were obtained. The former image showed scattered X-rays from the phantom. The latter image showed those from the air of beam axis as well as from the phantom. Moreover, we made a new proposal to obtain an optical image using the fading effect. (Keyword) pin-hole camera / scattered X-ray (Link to Publication Site) ● Publication site (DOI): 10.6009/jjrt.2012_JSRT_68.3.307 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206361540096 ● Search Scopus @ Elsevier (DOI): 10.6009/jjrt.2012_JSRT_68.3.307 (DOI: 10.6009/jjrt.2012_JSRT_68.3.307, CiNii: 1390001206361540096)
24.	Motoharu Sasaki, Masahide Tominaga, Hitoshi Ikushima, 岸太郎, 川下徹也, Yasuo Hara, 福永有希子, Masashi Kimura, Yasufumi Shitakubo, Satoru Takashi and Masataka Oita : Impact of multileaf collimator leaf positioning accuracy on intensity modulated radiation therapy., Japanese Journal of Radiological Technology, Vol.67, No.5, 497-506, 2011. (Summary) In multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT), the dose is influenced by the uncertainty of MLC driving control. In this study, we examined the influence of MLC driving control accuracy on dose evaluation (gamma analysis) by evaluating 60-day MLC driving control accuracy (stationary positioning accuracy and positioning reproducibility) once a week as well as measuring IMRT dose distribution. The MLC positioning accuracy accompanied variation over time and tended to expand by 0.1 to 0.15 mm in one week and about 1 mm in 60 days. In terms of reproducibility, errors were within 0.2 mm for more than 95%. For prostate IMRT, when MLC stationary positioning accuracy was around 1 mm, no significant difference was observed in the pass rate in gamma analysis. Therefore, the results suggest that regular maintenance by setting a permissible value determined by the MLC positioning accuracy test can be an effective indicator in the future for maintaining the safety of IMRT. (Keyword) multileaf collimator / positioning error / intensity modulated radiation therapy / dose distribution (Link to Publication Site) ● Publication site (DOI): 10.6009/jjrt.67.497 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21666373 ● CiNii @ National Institute of Informatics (CRID): 1390282681337851008 ● Summary page in Scopus @ Elsevier: 2-s2.0-84863934579 (DOI: 10.6009/jjrt.67.497, PubMed: 21666373, CiNii: 1390282681337851008, Elsevier: Scopus)
25.	Masahide Tominaga, Yoshiki Kawata, Noboru Niki, Noriyuki Moriyama, Kenji Yamada, Junji Ueno and Hiromu Nishitani : Measurements of multi-detector CT surface dose distributions using a film dosimeter and chest phantom, Medical Physics, Vol.38, No.5, 2467-2478, 2011. (Summary) This paper uses film dosimetry to investigate the relationship between multiple scan parameters of multidetector CT with automatic exposure control (AEC) and the surface dose distribution produced on a chest phantom. The characteristics of the film used in the film dosimeter were evaluated with regard to linearity, relative film response, and directional dependence. Measurements with an ionization chamber dosimeter and a water phantom were used to evaluate the accuracy of the film dosimeter measurements and to validate the dose profile measurements while changing the tube current, detector dimensions and pitch. When using AEC, the surface dose distribution on the chest phantom was analyzed while changing the detector dimensions and pitch. The linearity, relative film response, and directional dependence of the film were established. The measurement difference between the film dosimeter and ionization chamber dosimeter was within +/- 5% and the dose profile measurement results were validated. It was found that the surface dose distribution changed helically in the direction of the body axis depending on the scan parameters and the phantom. Using a film dosimeter, the relationship between various multidetector CT scan parameters and the surface dose distribution on a chest phantom was investigated and clarified. (Keyword) Algorithms / Film Dosimetry / Humans / Phantoms, Imaging / Radiation Dosage / Radiography, Thoracic / Tomography, X-Ray Computed (Link to Publication Site) ● Publication site (DOI): 10.1118/1.3570769 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21776782 ● Search Scopus @ Elsevier (PMID): 21776782 ● Search Scopus @ Elsevier (DOI): 10.1118/1.3570769 (DOI: 10.1118/1.3570769, PubMed: 21776782)
26.	Motoharu Sasaki, Masahide Tominaga, Hitoshi Ikushima, 岸太郎, 川下徹也, 原康男, 福永有希子, Kenji Yamada, Masataka Oita and Hiromu Nishitani : 強度変調放射線治療におけるradiographic filmと radiochromic filmの比較評価, Japanese Journal of Radiological Technology, Vol.66, No.5, 525-534, 2010. (Summary) Purpose: Radiographic film is generally used for inspection of dose distribution in intensity modulated radiation therapy (IMRT) at many institutions. However, the distribution of filmless systems can be expected to be used increasingly in the future. Therefore, we confirmed the utility of radiochromic film by comparing it with radiographic film that does not need an automatic processor. Result: Difference in does measured by radiographic film and radiochromic film tended to increase in the low does area, but it was limited in a range of 1.5%. Conclusion: When the dose distribution was verified in a highly accurate radiation therapy such as IMRT, the results suggested that radiochromic film can be useful in addition to radiographic film. (Keyword) radiochromic film / radiochromic film / dose distribution / dose distribution / intensity-modulated radiation therapy / intensity-modulated radiation therapy / radiographic film / radiographic film (Link to Publication Site) ● Publication site (DOI): 10.6009/jjrt.66.525 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206361620480 ● Summary page in Scopus @ Elsevier: 2-s2.0-77955931427 (DOI: 10.6009/jjrt.66.525, CiNii: 1390001206361620480, Elsevier: Scopus)
27.	Takashi Nakae, Yoshihiro Uto, Motoko Tanaka, Haruna Shibata, Eiji Nakata, Masahide Tominaga, Hiroshi Maezawa, Toshihiro Hashimoto, Kenneth L. Kirk, Hideko Nagasawa and Hitoshi Hori : Design, synthesis, and radiosensitizing activities of sugar-hybrid hypoxic cell radiosensitizers, Bioorganic & Medicinal Chemistry, Vol.16, No.2, 675-682, 2008. (Summary) We have designed sugar-hybrid TX-1877 derivatives conjugated with sugar moieties including β-glucose (β-Glc), β-galactose (β-Gal), α-mannose (α-Man) and N-acetyl-β-galactosamine (β-GalNAc). Compound 1 (TX-1877) was glycosylated with appropriate peracetylated sugars using BF3-OEt2 to give acetylated sugar-hybrids, 5 (TX-2244), 6 (TX-2245), 7 (TX-2246), and 10 (TX-2243). Removal of the acetyl groups afforded the sugar-hybrids having free hydroxyl groups, 11 (TX-2141), 12 (TX-2218), 13 (TX-2217) and 14 (TX-2068). We evaluated their radiosensitizing activities by an in vitro radiosensitization assay. All free hydroxyl hybrids have lower enhancement ratio (ER) values (ER 1.43) and lower n-octanol/water partition coefficient (Poct) values (Poct < 1.00 × 10-2) than does 1 (TX-1877, ER = 1.75, Poct: 5.60 × 10-2). All acetylated hybrids have similar Poct values (3.55 × 10-2 1.05 × 10-1) to 1 (TX-1877) and have improved ER values (ER 1.47) compared to the hybrids having free hydroxyl groups. Among these, 5 (TX-2244) is the most active radiosensitizer (ER = 2.30). We found a good correlation (r = 0.866) between the magnitude of Poct (logPoct) and the ER value of 5 (TX-2244), 6 (TX-2245), 7 (TX-2246), 10 (TX-2243) and 1 (TX-1877), suggesting that increasing the hydrophobicity is reflected in increased in vitro radiosensitizing activity. In the present study, we have succeeded in producing sugar-hybrid hypoxic cell radiosensitizers that have an increased radiosensitizing activity that does not depend on increased hydrophobicity. (Keyword) Hypoxic cell radiosensitizers / Sugar-hybrids / Electronic states / Hydrophobicity (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bmc.2007.10.035 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18029186 ● Search Scopus @ Elsevier (PMID): 18029186 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2007.10.035 (DOI: 10.1016/j.bmc.2007.10.035, PubMed: 18029186)

Academic Paper (Unrefereed Paper):

1.	Toshiya Arai, Hiroyoshi Imura, Hirofumi Yagi, Motokatsu Yasutomo, Atsushi Niki, Masafumi Amano, Masahide Tominaga, Kousuke Takashima and Tokue Kuroda : FUJI AD SYSTEMの基本特性の検討(2), Bulletin of School of Medical Sciences, the University of Tokushima, Vol.4, 191-195, 1994.
2.	Masahide Tominaga, Hirofumi Yagi, Motokatsu Yasutomo, Masafumi Amano, Kousuke Takashima, Hiroyoshi Imura, Ken Nakao and Tokue Kuroda : FUJI AD SYSTEMの基本特性の検討(1), Bulletin of School of Medical Sciences, the University of Tokushima, Vol.3, 185-190, 1994.

Review, Commentary:

1.	Hirofumi Honda, Masahide Tominaga, Motoharu Sasaki, Masataka Oita and Yoshihiro Uto : 放射線治療における透過型検出器の現状と展望, Radiation Biology Research Communications, Vol.56, No.3, 245-259, Sep. 2021. (Keyword) 透過型検出器 / 生体内線量測定 / 強度変調回転放射線治療 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520853835303095424 (CiNii: 1520853835303095424)
2.	Masahide Tominaga, 下窪康史, Hitoshi Ikushima, 本田道隆 and Motoharu Sasaki : Cone-beam CT 画像を用いた小線源治療計画への応用, 画像通信, Vol.77, No.2, 55-61, Oct. 2016.
3.	本田弘文, Masataka Oita, Masahide Tominaga and Yoshihiro Uto : 放射線治療における In Vivo Dosimetryの発展と応用, Radiation Biology Research Communications, Vol.51, No.3, 255-267, Sep. 2016.
4.	原毅弘, Masahide Tominaga, Masataka Oita, 本田弘文 and Yoshihiro Uto : Flattening Filter Free(高線量率)モードを用いた放射線治療の効果, Radiation Biology Research Communications, Vol.51, No.3, 230-240, Sep. 2016.
5.	芝一休, Hisatsugu Yamada, Masahide Tominaga and Yoshihiro Uto : 低酸素を標的とした抗転移剤による化学放射線療法の可能性, Radiation Biology Research Communications, Vol.51, No.3, 216-229, Sep. 2016.
6.	Nishitani Hiromu, Ysutomo Motokatsu, Masahide Tominaga, Fukui Toshihito and Hirofumi Yagi : 特集:放射線診療における被曝, Nippon Acta Radiologica, Vol.62, No.7, 347-351, Jun. 2002.

Proceeding of International Conference:

1.	Hinata Ikeda, Hiroyuki Ukida, Kouki Yamazoe, Masahide Tominaga, Tomoyo Sasao and Kenji Terada : 3D Shape Reconstruction of Puppet Head from CT Images by Machine Learning, Proceedings of the SICE Annual Conference 2022, 592-597, Kumamoto, Sep. 2022. (Link to Publication Site) ● Publication site (DOI): 10.23919/SICE56594.2022.9905783 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85141149056 (DOI: 10.23919/SICE56594.2022.9905783, Elsevier: Scopus)
2.	Hiroyuki Ukida, Koki Yamazoe, Masahide Tominaga, Tomoyo Sasao and Kenji Terada : 3D Shape Reconstruction of Japanese Traditional Puppet Head from CT images, The 28th International Workshop on Frontiers of Computer Vision (IW-FCV2022), 239-251, Hiroshima, Feb. 2022. (Link to Publication Site) ● Publication site (DOI): 10.1007/978-3-031-06381-7_4 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85131138428 (DOI: 10.1007/978-3-031-06381-7_4, Elsevier: Scopus)
3.	Hiroyuki Ukida, Yoshitaka Hatakenaka, Masahide Tominaga, Tomoyo Sasao, Kenji Terada and Atsuya Yoshida : Inner and outer 3D shape reconstruction of puppet head from CT images, Proceedings of SPIE, Vol.11794, 1179404, Tokyo, Jul. 2021. (Link to Publication Site) ● Publication site (DOI): 10.1117/12.2588748 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85112437460 (DOI: 10.1117/12.2588748, Elsevier: Scopus)
4.	Yoshitaka Hatakenaka, Hiroyuki Ukida, Masahide Tominaga, Tomoyo Sasao, Kenji Terada and Atsuya Yoshida : 3D Shape Reconstruction of Puppet Head from CT images, Proceedings of the SICE Annual Conference 2020, 701-705, Chiang Mai (Online), Sep. 2020. (Summary) In this paper, we discuss a method to measure 3D shape of puppet head for a digital archiving. In order to reconstruct an inner shape of head, we use CT images. Firstly, we divide four regions (wood, hair, paint and air) by thresholds which obtained by manual directed regions. After that, we divide these regions by a graph cut method. We apply this method to a puppet head and we confirm effectiveness of our proposed method. (Keyword) X-ray CT images / Puppets / shape reconstruction / Graph cut method
5.	Hasegawa Yu, Akihiro Haga, Sakata Dousatsu, Yuki Kanazawa, Masahide Tominaga, Motoharu Sasaki, Imae T. and Nakagawa Keiichi : Estimation of X-ray energy spectrum for CT scannerfrom percentage depth dose measurement, 2020 JOINT AAPM COMP meeting, Jul. 2020.
6.	Honda Hirofumi, Masahide Tominaga, Motoharu Sasaki, Yoshihiro Uto, Masataka Oita, Hamamoto Yasushi, Mochizuki Teruhito, Kido Teruhito, Ishii Y, Yamamoto Ryuji and Omoto K : Detectability of MLC Stop Position Error During Treatment by Gantry-Mounted Transmission Detector, AAPM 62th annual meeting (WEB), Jul. 2020.
7.	Motoharu Sasaki, Hitoshi Ikushima, Kenta Kitagawa, Yohsuke Kanoh, Masahide Tominaga, Hirofumi Honda, Wataru Sugimoto and Masataka Oita : Impact of Changes in Body Shapes on Radiation Therapy Dose Distribution After Uterine Cervical Cancer Surgery, AAPM 62th annual meeting (WEB), Jul. 2020.
8.	Masataka Oita, M Udaka, H Aoyama, Motoharu Sasaki, Masahide Tominaga and Yoshihiro Uto : Immunological aspects of Improved Tumor and Normal Tissue Responses Using Biophysical modelling, AAPM 60th Annual Meeting, Jul. 2018.
9.	Honda Hirofumi, Kubo Kei, Yamamoto Ryuuji, Ishii Yoshiaki, Kanzaki Hiromitsu, Hmamoto Yasushi, 望月輝一, Masataka Oita, Motoharu Sasaki, Masahide Tominaga and Yoshihiro Uto : Feasibility of dose delivery error detection by a transmission detector for patient-specific QA, Radiotherapy and Oncology, Vol.123, No.1, S787-S788, May 2017. (Link to Publication Site) ● Publication site (DOI): 10.1016/S0167-8140(17)31909-6 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/S0167-8140(17)31909-6 (DOI: 10.1016/S0167-8140(17)31909-6)
10.	Motoharu Sasaki, Hitoshi Ikushima, Masahide Tominaga, 川下徹也, Takeshi Kamomae, Ryota Bandoh, Kanako Sakuragawa and Masataka Oita : Dose impact of rectal gas on prostate VMAT, AAPM 58th Annual Meeting, Jul. 2016.
11.	Masataka Oita, Nakata K., Motoharu Sasaki, Masahide Tominaga, Hideki Aoyama, Hirofumi Honda and Yoshihiro Uto : Does the Biophysical Modeling for Immunological Aspects in Radiotherapy Precisely Predict Tumor and Normal Tissue Responses?, AAPM 58th Annual Meeting, Jun. 2016.
12.	Masataka Oita, Hideki Aoyama, Motoharu Sasaki, Masahide Tominaga, Hirofumi Honda and Yoshihiro Uto : Application of biophysical modelling for normal tissue response with immunological aspects in radiotherapy, Radiotherapy and Oncology, Vol.118, No.S1, S79-S80, Feb. 2016. (Link to Publication Site) ● Publication site (DOI): 10.1016/s0167-8140(16)30162-1 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/s0167-8140(16)30162-1 (DOI: 10.1016/s0167-8140(16)30162-1)
13.	Takehiro Hara, Masahide Tominaga, Hideaki Endo and Yoshihiro Uto : The effect of dose rate on radiation-induced in vitro antitumor activity by low-LET radiation., 15th International Congress of Radiation Research (ICRR2015), May 2015.
14.	Masataka Oita, Yoshihiro Uto, Hitoshi Hori, Masahide Tominaga and Motoharu Sasaki : Effects of Uncertainties of Radiation Sensitivity of Biological Modelling for Treatment Planning, AAPM 56th Annual Meeting, Jun. 2014.
15.	Yoshihiro Uto, Chiaki Abe, Takashi Nakae, Yoshio Endo, Masahide Tominaga, Hiroshi Maezawa, Eiji Nakata and Hitoshi Hori : Systems biology-based drug design of sugar-hybrid hypoxic cell radiosensitizers using the tumor-implantable chick embryo model, PACIFICHEM 2010, Honolulu, Dec. 2010.

Proceeding of Domestic Conference:

1.	IKEDA Hinata, Hiroyuki Ukida, Masahide Tominaga, Tomoyo Sasao and Kenji Terada : CT 画像を用いた浄瑠璃人形の頭の材質識別, Proceedings of Vision Engineering Workshop (ViEW2023), 171-178, Dec. 2023.
2.	Koki Yamazoe, Hiroyuki Ukida, HINATA Ikeda, Masahide Tominaga, Tomoyo Sasao and Kenji Terada : PSPNet を用いた CT 画像からの浄瑠璃人形の頭の形状復元, Proceedings of Vision Engineering Workshop (ViEW2022), 244-248, Dec. 2022.
3.	Masahide Tominaga : 第22回画像処理表計算研修セミナー(深層学習編)「深層学習の数学的基礎」, 日本放射線技術学会中国四国支部, Nov. 2022.
4.	Masahide Tominaga : 第1回診断X線領域の線量測定基礎Webセミナー「測定動画の説明」, 日本放射線技術学会, Nov. 2022.
5.	Masahide Tominaga : 計測分野におけるAI研究の動向，他学会との比較, 第50回日本放射線技術学会秋季学術大会, Oct. 2022.
6.	Masahide Tominaga : 第21回画像処理表計算研修セミナー(深層学習編)「深層学習の数学的基礎」, 日本放射線技術学会中国四国支部, Jan. 2022.
7.	Takumi Morita and Masahide Tominaga : 深層学習を用いた胸部単純 X 線画像の低線量画像から高画質画像生成の試み, 第17回中国四国放射線医療技術フォーラム(WEB開催),, Dec. 2021.
8.	Masahide Tominaga, 武井靖奈, Takumi Morita and 角谷和俊 : モンテカルロシミュレーションにおける深層学習用トレーニング画像の生成, 第17回中国四国放射線医療技術フォーラム(WEB開催),, Dec. 2021.
9.	Masahide Tominaga, Kazutoshi Sumiya, Takumi Morita and 武井靖奈 : 深層学習を用いた非小細胞肺癌におけるトリミングサイズの違いによる分類精度の検討, 第17回中国四国放射線医療技術フォーラム(WEB開催),, Dec. 2021.
10.	Masahide Tominaga : 光子と物質との相互作用, 日本放射線技術学会, Apr. 2021.
11.	Hirofumi Honda, Masahide Tominaga, Motoharu Sasaki, Masataka Oita, 石井香明, 山本竜次, 大元謙二, 上津孝太郎, 城戸輝仁 and Yoshihiro Uto : ガントリー搭載型検出器を用いたMLC位置エラーのγ解析の検討, 第34回高精度放射線外部照射部会学術大会(WEB開催), Apr. 2021.
12.	Masahide Tominaga : 第21回画像処理表計算研修セミナー(深層学習編)「深層学習の数学的基礎」, 日本放射線技術学会中国四国支部, Jan. 2021.
13.	Yoshitaka Hatakenaka, Hiroyuki Ukida, Masahide Tominaga, Tomoyo Sasao, Kenji Terada and Atsuya Yoshida : CT画像からの浄瑠璃人形の頭内部の三次元形状復元, Vision Engineering Workshop (ViEW2020), IS2-08, Dec. 2020.
14.	Hiroyuki Ukida, Yoshitaka Hatakenaka, Masahide Tominaga, Tomoyo Sasao, Kenji Terada and Atsuya Yoshida : 3D Shape Reconstruction of Inner Puppet Head using CT images, 電気学会研究会資料(知覚情報・次世代産業システム合同研究会), 39-44, Oct. 2020.
15.	Hiroyuki Ukida, Yoshitaka Hatakenaka, Masahide Tominaga, Tomoyo Sasao, Kenji Terada and Atsuya Yoshida : 3D Shape Reconstruction of Inner Puppet Heads using CT images, 2020年度非破壊検査総合シンポジウム, 56-62, Jun. 2020.
16.	Motoharu Sasaki, Kenta Kitagawa, Yohsuke Kanoh, Masahide Tominaga and Hitoshi Ikushima : 体輪郭の変化が子宮頸がん術後照射VMATの線量分布へ及ぼす影響, 第33回高精度放射線外部照射部会学術大会(WEB開催), May 2020.
17.	Yu Hasegawa, Akihiro Haga, Dousatsu Sakata, Yuki Kanazawa, Masahide Tominaga, Motoharu Sasaki, Toshikazu Imae and Keiichi Nakagawa : Estimation of X-ray energy spectrum for CT scanner from percentage depth dose measurement, 第119回⽇本医学物理学会学術⼤会WEB開催, May 2020.
18.	Yoshitaka Hatakenaka, Hiroyuki Ukida, Masahide Tominaga, Tomoyo Sasao, Kenji Terada and Atsuya Yoshida : 3D Shape Reconstruction of Puppet Head using CT images, 電気学会研究会資料(知覚情報・次世代産業システム合同研究会), Mar. 2020.
19.	Yoshihiro Uto, Daisuke Konishi, Nami Orimura, Hisatsugu Yamada, Masahide Tominaga, Hitoshi Ikushima, Kei Daizumoto and Hisanori Uehara : リニアックの FFFビームに対する新規増感剤の創製, 第22回癌治療増感シンポジウム, Feb. 2020.
20.	Hirofumi Honda, Masahide Tominaga, Motoharu Sasaki, Masataka Oita, 石井香明, 高田紀子, 鶴岡慎太郎, 石川浩史, 濱本泰, 望月輝一 and Yoshihiro Uto : ガントリー搭載型検出器を用いたMLC解析の検討, 第32回日本放射線腫瘍学会学術大会, Nov. 2019.
21.	Daisuke Konishi, Mana Futawaka, Yuri Fujiwara, Nami Orimura, Hisatsugu Yamada, Masahide Tominaga, Hitoshi Ikushima, Hisanori Uehara, Kei Daizumoto and Yoshihiro Uto : 医療用直線加速器の高線量率モードX線に対するGemcitabineの増感効果, 日本化学会中国四国支部大会徳島大会, Nov. 2019.
22.	Motoharu Sasaki, Masahide Tominaga, Kanako Sakuragawa, 横石道寛, Kyohei Ishikawa, Kenta Kitagawa, Yohsuke Kanoh and Hitoshi Ikushima : 3次元線量検証システムを用いた長期安定性の調査, 第47回日本放射線技術学会秋季学術大会, Oct. 2019.
23.	Yukari Nagayasu, Masahide Tominaga, 安友基勝, Takeshi Kojima, Motoharu Sasaki and Kenji Yamada : Edge Spread Functionの最適化によるMTF測定精度向上の試み, 第15回中国四国放射線医療技術フォーラムCSFRT2019, Sep. 2019.
24.	永安結花里, Masahide Tominaga, 古田琢哉 and Motoharu Sasaki : モンテカルロシミュレーションを用いた診断用X線の放射線計測における後方散乱線の影響解析, 第15回中国四国放射線医療技術フォーラムCSFRT2019, Sep. 2019.
25.	Masahide Tominaga, 山内奈緒, Akihiro Haga, Motoharu Sasaki and Takeshi Kojima : 治療計画用CT画像を用いた非小細胞肺癌の病理分類, 第15回中国四国放射線医療技術フォーラムCSFRT2019, Sep. 2019.
26.	Yoshihiro Uto, Ayaka Hanyu, Yuki Kusuhashi, Mana Futawaka, Hisatsugu Yamada, Masahide Tominaga and Hitoshi Ikushima : 医療用直線加速器の高線量率モードX線を増感する抗がん剤の探索, 第25回癌治療増感研究会, Jun. 2019.
27.	Motoharu Sasaki, Masahide Tominaga, 川下徹也, 横石道寛, Kanako Sakuragawa and Hitoshi Ikushima : VMATにおけるplan normalization valueが線量検証へ及ぼす影響, 第32回高精度放射線外部照射部会学術大会, Mar. 2019. (Keyword) VMAT / quality assurance / head and neck / plan normalization value
28.	Ayaka Hanyu, Risa Kouzaki, Kazuki Ueshima, Tomoko Kaneko, Hisatsugu Yamada, Masahide Tominaga, 壽賀正城, 山下智弘, 沖本智昭 and Yoshihiro Uto : 5-アミノレブリン酸およびプロトポルフィリンⅨの炭素線増感作用, 日本化学会第98春季年会, Mar. 2018.
29.	Masahide Tominaga, Motoharu Sasaki, Motokatsu Yasutomo, Kenji Yamada, Takeshi Kojima, Akihiro Haga, Hitoshi Ikushima and 角谷倫之 : Digital Phantomを用いたImage Registrationソフトウェアの性能評価, 第31回高精度放射線外部照射部会学術大会, Feb. 2018.
30.	Ryosuke Fukura, 川下徹也, Motoharu Sasaki, Shota Azane and Masahide Tominaga : 2種類の3次元水ファントムを用いたスキャンデータの比較検討, 第13回中四国放射線医療技術フォーラム(CSFRT2017 ), Dec. 2017.
31.	Tomoko Kaneko, Risa Kouzaki, Ayaka Hanyu, Hisatsugu Yamada, Yoshihiro Uto, 壽賀正城, 山下智弘, 沖本智昭 and Masahide Tominaga : 5-アミノレブリン酸およびその代謝物であるプロトポルフィリンⅨの炭素線増感作用, 第21回バイオ治療法研究会, Dec. 2017.
32.	Kenji Yamada, Motokatsu Yasutomo, Motoharu Sasaki, Kanako Sakuragawa, Masahide Tominaga, Ryosuke Kasai, 井上直 and 鹿重俊哉 : 確率密度関数を用いたエッジ法におけるMTF測定時のLSF取得法, 第45回日本放射線技術学会秋季学術大会, Oct. 2017.
33.	Kanako Sakuragawa, Motokatsu Yasutomo, Kenji Yamada, Motoharu Sasaki, Masahide Tominaga, Ryosuke Kasai, 井上直 and 鹿重俊哉 : ディジタル乳房撮影装置の焦点のボケ関数から導かれる焦点サイズの推定法, 第45回日本放射線技術学会秋季学術大会, Oct. 2017.
34.	Masahide Tominaga, Motoharu Sasaki, 安友基勝, Takeshi Kojima, Kenji Yamada, Hitoshi Ikushima and 角谷倫之 : 市販Image registrationソフトウェアの評価用Digital Phantomの開発, 日本放射線腫瘍学会第30回高精度外部放射部会学術大会, Mar. 2017.
35.	Tomohiro Sagawa, Masahide Tominaga, 田中翼, Motoharu Sasaki, 本田道隆 and Hitoshi Ikushima : Computed Radiography を用いた Multi-Leaf collimator の精度管理, 医用画像情報学会(MII), Oct. 2016.
36.	下窪康史, Masahide Tominaga, Ryosuke Kasai, Motoharu Sasaki, 田中翼, 佐川友啓, 本田道隆 and Hitoshi Ikushima : 子宮頸癌に対する腔内小線源治療計画時におけるCBCT画像の画質評価, 医用画像情報学会(MII), Oct. 2016.
37.	松本晃範, Masahide Tominaga, Motoharu Sasaki, Hiroaki Hayashi, 岡崎徹, 橋詰拓弥 and 小林育夫 : Accumulated-dose Dependence of Measured Values of Small Type OSL Dosimeter in Radiotherapy, 第72回日本放射線技術学会学術大会, Apr. 2016.
38.	Motoharu Sasaki, Masahide Tominaga, 松本晃範, Hiroaki Hayashi, 岡崎徹, 橋詰拓弥 and 小林育夫 : Evaluation of surface dose using originally-produced bolus toward head and neck radiotherapy, 第72回日本放射線技術学会学術大会, Apr. 2016.
39.	Masahide Tominaga, Motoharu Sasaki, Motoharu Sasaki, Kento Tanaka, 安友基勝, 山田健二 and Hitoshi Ikushima : 市販Image registrationソフトウェアの画像類似度の比較評価, 日本放射線腫瘍学会第29回高精度外部放射部会学術大会, Feb. 2016.
40.	Yoshihiro Uto, 遠藤秀彰, 八重和憲, Hisatsugu Yamada, 原毅弘 and Masahide Tominaga : TrueBeamを用いた低LET放射線の線量率と生物効果の相関について, 第18回癌治療増感研究シンポジウム, Feb. 2016.
41.	Kento Tanaka, Masahide Tominaga, Motoharu Sasaki, 安友基勝 and 山田健二 : 市販Image registrationソフトウェアの画像類似度の比較評価, 第11回中国四国放射線技術フォーラム, Nov. 2015.
42.	Masahide Tominaga, Hideaki Endo, Takahiro Hara and Yoshihiro Uto : 細胞を用いた低LET放射線の線量率と抗腫瘍効果の相関, 第11回中国四国放射線技術フォーラム, Nov. 2015.
43.	松本晃範, Masahide Tominaga, Motoharu Sasaki, 宇恵希, 森田里佳, Hiroaki Hayashi, 岡崎徹 and 小林育夫 : Evaluation of consecutive read values of small-type OSL dosimeter in radiation therapy region., 第43回日本放射線技術学会秋季学術大会, Oct. 2015.
44.	Kyo Yamashita, Hitoshi Ikushima, Akiko Kubo, Takashi Kawanaka, Shunsuke Furutani, Kyosuke Osaki, Takaharu Kudoh, Masahide Tominaga and 仁木孝明 : 放射線治療に携わるスタッフのストレス状況∼徳島県の場合∼, 日本放射線腫瘍学会27回学術大会, Dec. 2014.
45.	曽我部翔, Masahide Tominaga, 松本晃範, Motoharu Sasaki, 中川滉平, Hiroaki Hayashi and 岡崎徹 : 高エネルギーX線における小型 OSL 線量計の基本特性, 第10回中四国放射線医療技術フォーラム, Oct. 2014.
46.	松本晃範, Masahide Tominaga, 曽我部翔, Hiroaki Hayashi and Motoharu Sasaki : 診断領域のX線における後方散乱線についての一考察, 第10回中四国放射線医療技術フォーラム, Oct. 2014.
47.	Motoharu Sasaki, 岸太郎, 藤田明彦, 川下徹也, Yasuo Hara, 三枝裕司, 下窪康史, Masahide Tominaga and 多田章久 : 頭頸部 VMAT における治療計画装置のバージョンの違いに関する治療計画評価, 中四国放射線医療技術, Oct. 2014.
48.	Masataka Oita, Yoshihiro Uto, Hitoshi Hori, Masahide Tominaga, Motoharu Sasaki and 岸太郎 : 細胞間放射線感受性の違いを考慮した治療計画技術応用に関する基礎的検討, 第16回癌治療増感研究シンポジウム, Feb. 2014.
49.	Masataka Oita, Yoshihiro Uto, Hitoshi Hori, Masahide Tominaga, Motoharu Sasaki and 岸太郎 : 細胞間放射線感受性の違いを考慮した最適放射線治療計画法に関する検討, 第17回バイオ治療法研究会学術集会, Dec. 2013.
50.	Ryosuke Fukura, Masahide Tominaga, Hitoshi Ikushima, Keigo Masuda, 岸太郎 and Motoharu Sasaki : 前立腺 IMRT および VMAT 計画評価におけるレトロスペクティブ解析, 中四国放射線医療技術フォーラム2014, Nov. 2013.
51.	Keigo Masuda, Masahide Tominaga, Hitoshi Ikushima, Ryosuke Fukura, 岸太郎 and Motoharu Sasaki : 6 軸治療寝台システムを用いた位置精度に関する基礎的検討, 中四国放射線医療技術フォーラム2014, Nov. 2013.
52.	原毅弘, Yoshihiro Uto, Ayaka Nakashima, Koushirou Fukushima, Chiho Noguchi, 遠藤良夫, Hiroshi Maezawa, Masahide Tominaga, 福本修一 and Hitoshi Hori : 発育鶏卵を用いたオオバギ葉抽出物の放射線防護活性の評価, 第19回癌治療増感研究会, Jun. 2013.
53.	廣田充宏, Masahide Tominaga, Motoharu Sasaki, 鎌田真奈, Yoshihiro Tanaka, Yasuo Hara, 坂東良太 and Hitoshi Ikushima : 三次元検出器システムの特性に関する検討, 第8回中四国放射線医療技術フォーラム, Oct. 2012.
54.	鎌田真奈, Masahide Tominaga, Motoharu Sasaki, 廣田充宏, Yoshihiro Tanaka, Yasuo Hara, 坂東良太 and Hitoshi Ikushima : 三次元検出器システムの特性に関する検討, 第8回中四国放射線医療技術フォーラム, Oct. 2012.
55.	Motoharu Sasaki, 岸太郎, 川下徹也, Yasuo Hara, 三枝裕司, 福永有希子, 下窪康史, Masahide Tominaga and 多田章久 : 多発脳転移における VMAT の検討 ∼線量検証∼, 第8回中四国放射線医療技術フォーラム, Oct. 2012.
56.	Motoharu Sasaki, 岸太郎, 川下徹也, Yasuo Hara, 三枝裕司, 福永有希子, 下窪康史, Masahide Tominaga and 多田章久 : 多発脳転移における VMAT の検討 ∼治療計画∼, 第8回中四国放射線医療技術フォーラム, Oct. 2012.
57.	Masahide Tominaga, Motoharu Sasaki, 鎌田真奈, 廣田充宏, Yoshihiro Tanaka, Yasuo Hara, 坂東良太 and Hitoshi Ikushima : 三次元検出器の特性に関する検討, 第25回高精度放射線治療研究会, Jul. 2012.
58.	田辺円花, 湯浅千尋, Masahide Tominaga, Motoharu Sasaki and Hitoshi Ikushima : MUの独立検証, Oct. 2010.
59.	湯浅千尋, 田辺円花, Masahide Tominaga, Motoharu Sasaki and Hitoshi Ikushima : CR装置を用いたMLCのQAについての一考察, Oct. 2010.
60.	Yoshihiro Uto, 安部千秋, 中江崇, 村井絵美, 遠藤良夫, Masahide Tominaga, Hiroshi Maezawa, 慎一郎増永, Eiji Nakata and Hitoshi Hori : 腫瘍移植鶏卵モデルによる糖ハイブリッド放射線増感剤のin vivo放射線増感活性の評価, 第16回国際癌治療増感研究会, Jun. 2010.
61.	Takashi Nakae, Yoshihiro Uto, Chiaki Abe, Takeyuki Kanazono, Yuuya Shinmoto, Keiichiro Sano, Eiji Nakata, Yoshio Endo, Masahide Tominaga, Hiroshi Maezawa, Toshihiro Hashimoto, 慎一郎増永 and Hitoshi Hori : 鶏胚異種移植腫瘍モデルを基盤とした糖ハイブリッド低酸素細胞放射線増感剤の創製, 創薬懇話会2009, Dec. 2009. (Keyword) 鶏胚異種移植腫瘍モデル / 糖ハイブリッド低酸素細胞放射線増感剤
62.	高志智, 岸太郎, 藤田明彦, 川下徹也, 原康男, 佐々木幹治, 福永有希子, 山田健二 and Masahide Tominaga : 前立腺IMRT線量検証の初期経験, 中四国放射線医療技術フォーラム CSFRT2009 in SHIMANE, Nov. 2009.
63.	福永正明, 河淵聡, 岸太郎, 佐々木幹治, 原康男, 山田健二 and Masahide Tominaga : モニタ線量計の1日安定性, 中四国放射線医療技術フォーラム CSFRT2009 in SHIMANE, Nov. 2009.
64.	河淵聡, 福永正明, 岸太郎, 佐々木幹治, 山田健二, Masahide Tominaga and Hitoshi Ikushima : MUの独立検証, 中四国放射線医療技術フォーラム CSFRT2009 in SHIMANE, Nov. 2009.
65.	Masahide Tominaga : 日本と米国の技師制度の違い, 中四国放射線医療技術フォーラム CSFRT2009 in SHIMANE, Nov. 2009.
66.	Yoshihiro Uto, 中江崇, 安部千秋, 新元優也, 佐野圭一郎, 遠藤良夫, Masahide Tominaga, Hiroshi Maezawa, Eiji Nakata and Hitoshi Hori : 腫瘍移植鶏卵モデルによる糖ハイブリッド放射線増感剤の薬物動態解析, 第15回国際癌治療増感研究会, Jun. 2009.
67.	金園剛行, Yoshihiro Uto, 中江崇, 柴田明奈, 中島宏一郎, 佐野圭一郎, Masahide Tominaga, Hiroshi Maezawa, Eiji Nakata and Hitoshi Hori : メチル化グルコース・糖ハイブリッド低酸素細胞放射線増感剤の分子設計, 日本薬学会第129年会, Mar. 2009.
68.	中江崇, Yoshihiro Uto, 安部千秋, 新元優也, 金園剛行, 中島宏一郎, 佐野圭一郎, Masahide Tominaga, Hiroshi Maezawa, 慎一郎増永, 遠藤良夫, Eiji Nakata and Hitoshi Hori : 腫瘍移植鶏卵モデルによる糖ハイブリッド低酸素細胞放射線増感剤TX-2244の腫瘍移行性, 日本薬学会第129年会, Mar. 2009.
69.	中島宏一郎, 中江崇, 柴田明奈, 田中智子, Yoshihiro Uto, Masahide Tominaga, Hiroshi Maezawa, Eiji Nakata, Hideko Nagasawa and Hitoshi Hori : がんによるグルコースの高い取り込みを利用した糖ハイブリッド低酸素細胞放射線増感剤の分子設計, 日本薬学会第128年会, Mar. 2008.
70.	川上雄司, 武市直也, 寺地拓人, 加藤久美子, 佐々木幹治, Masahide Tominaga and Yoshihiro Takegawa : 放射線治療いおける頭頸部固定用シェルの固定精度に関する検討第二報臨床データの解析, 中四国放射線医療技術フォーラム CSFRT2007 in HIROSHIMA, Nov. 2007.
71.	Masahide Tominaga, 川上雄司, 武市直也, 寺地拓人, 加藤久美子, 佐々木幹治 and Yoshihiro Takegawa : 頭頸部固定用シェルの固定精度に関する検討第一報位置照合ソフトウエアについて, 中四国放射線医療技術フォーラム CSFRT2007 in HIROSHIMA, Nov. 2007.
72.	Yoshihiro Uto, Masahide Tominaga, Takashi Nakae, Motoko Tanaka, Aya Murakami, Yuki Sasaki, Haruna Shibata, Kouichiro Nakashima, Eiji Nakata, Hideko Nagasawa and Hitoshi Hori : 低酸素がん選択的ハイブリッド型放射線増感剤の創製, 第13回癌治療増感研究会, May 2007.
73.	田中智子, Yoshihiro Uto, Masahide Tominaga, 中江崇, 村上綾, Hideko Nagasawa and Hitoshi Hori : 低酸素腫瘍移行性糖ハイブリッド放射線増感剤の創製, 第9回癌治療増感研究シンポジウム, Feb. 2007.
74.	Hiroyuki Gotou, Takahiro Sumii, Soushuu Tamaki, Yoshihiro Tanaka, 八木浩史, Sadamitsu Nishihara and Masahide Tominaga : RMI 156ファントム画像の画質に関する検討: 物理特性と視覚評価の比較, 中四国放射線医療技術, No.2, 127, Jan. 2007.
75.	Yoshihiro Tanaka, Takahiro Sumii, Hiroyuki Gotou, Soushuu Tamaki, 八木浩史, Sadamitsu Nishihara and Masahide Tominaga : 一般X線撮影領域における蛍光ガラス線量計の特性, 中四国放射線医療技術, No.2, 94, Jan. 2007.
76.	佐々木幹治, 岸太郎, 藤田明彦, 川下徹也, 原康男, 福永有希子, 高志智, 山田健二, Masahide Tominaga and 川口和雅 : 前立腺IMRTにおけるinter-fractional organ motionについての検討, 中四国放射線医療技術フォーラム CSFRT2007 in HIROSHIMA, 2007.
77.	前田瑞季, 米倉広宣, 佐々木幹治, Masahide Tominaga and Yoshihiro Takegawa : 放射線治療における頭頸部固定用シェルの精度に関する検討, 中四国放射線医療技術フォーラム(香川), Nov. 2006.
78.	山田健二, 安友基勝, Masahide Tominaga, 宮田英幸 and Junji Ueno : Real-ECの特性に関する検討, Dec. 2005.
79.	宮田英幸, 安友基勝, Masahide Tominaga, 山田健二 and Junji Ueno : Real-ECの特性に関する検討, Dec. 2005.
80.	Masahide Tominaga, 安友基勝, 山田健二, 宮田英幸, Hirofumi Yagi, Junji Ueno and Hiromu Nishitani : ファントムにおける線量分布のシミュレーション, Dec. 2005.
81.	川野浩司, 真鍋理恵, 加茂前健, 日出山信, Masataka Oita, Yoshihiro Takegawa, 佐々木幹治, Masahide Tominaga, 原康男, 岸太郎 and 西本安雄 : 反射型フイルムの諸特性に関する検討, 中四国放射線医療技術, Vol.1, No.1, 75, Nov. 2005.
82.	真鍋理恵, 川野浩司, 加茂前健, 日出山信, Masataka Oita, Yoshihiro Takegawa, 佐々木幹治, Masahide Tominaga, 原康男, 岸太郎 and 西本安雄 : 反射型フイルムの諸特性に関する検討, 中四国放射線医療技術, Vol.1, No.1, 74, Nov. 2005.
83.	加茂前健, 日出山信, 真鍋理恵, 川野浩司, Masataka Oita, Yoshihiro Takegawa, 佐々木幹治, Masahide Tominaga, 原康男, 岸太郎 and 西本安雄 : 東芝(Siemens)製リニアックのIMRT初期導入に関する検討, 中四国放射線医療技術, Vol.1, No.1, 73, Nov. 2005.
84.	日出山信, 加茂前健, 川野浩司, 真鍋理恵, Masataka Oita, Yoshihiro Takegawa, 佐々木幹治, Masahide Tominaga, 原康男, 岸太郎 and 西本安雄 : 東芝(Siemens)製リニアックのIMRT初期導入に関する検討, 中四国放射線医療技術, Vol.1, No.1, 72, Nov. 2005.
85.	Hirofumi Yagi, 安友基勝, Masahide Tominaga, 原康夫, 佐々木幹治, 福居壽人 and 西谷弘 : MDCTによる被検者の線量分布の推定, 日本放射線技術学会第61回総会学術大会, Apr. 2005.
86.	Hirofumi Yagi, Masahide Tominaga, Yasuo Hara, Kanji Sasaki, Motokatsu Yasutomo, Takashi Ueno and Hiromu Nishitani : 16列MDCTによるファントムの線量分布の測定, 日本放射線技術学会第61回総会学術大会, Apr. 2005.
87.	Masataka Oita, Hitoshi Ikushima, Masahide Tominaga, Hirofumi Yagi, Kyosuke Osaki, Yoshihiro Takegawa, Hiromu Nishitani and 渡辺良晴 : マイクロMLC搭載自走式CTリニアック装置のQA/QC, 日本放射線腫瘍学会第17回学術大会(千葉)日本放射線腫瘍学会誌, Vol.16, No.Suppl. 1, 142, Nov. 2004.
88.	Hirofumi Yagi, Masahide Tominaga, Yasuo Hara, Kanji Sasaki, Takashi Ueno, Tosihito Fukui, Motokatsu Yasutomo, Hiroaki Kanno and Hiromu Nishitani : 16列MDCTによるファントムの線量プロファイルの測定, 日本放射線技術学会中国·四国部会第45回学術大会, Nov. 2004.
89.	Hirofumi Yagi, Toshihito Fukui, Masahide Tominaga, Motokatsu Yasutomo and Hiroaki Kanno : CT検査時の患者表面線量分布の測定第3報, 日本放射線技術学会第29回秋季学術大会, Nov. 2001.
90.	Hirofumi Yagi, Masahide Tominaga, Toshihito Fukui, Motokatsu Yasutomo and Hiroaki Kanno : CT検査時の患者表面線量分布の測定第2報, 日本放射線技術学会第29回秋季学術大会, Nov. 2001.
91.	Hirofumi Yagi, Motokatsu Yasutomo, Hiroaki Kanno, Toshihito Fukui and Masahide Tominaga : CT検査時の患者表面線量分布の測定第1報, 日本放射線技術学会第29回秋季学術大会, Nov. 2001.
92.	天野雅史, Masahide Tominaga, 安友基勝, 福井義治, 高島宏輔, Hirofumi Yagi and Hiroyoshi Imura : 距離法によるセンシトメトリの再検討, 日本放射線技術学会第37回中国·四国部会学術大会, Sep. 1996.
93.	川下隆宏, 天野雅史, Masahide Tominaga, 坂野啓一, 上野誉史, 安友基勝, 高島宏輔, 福井義治, Hiroyoshi Imura and Hirofumi Yagi : New ortho film, Fuji UR-3についての検討(1), 日本放射線技術学会第1回四国支部学術大会, Jun. 1996.
94.	高島宏輔, 安友基勝, 福井壽人, 団英司, 山田伸一, 天野雅史, Masahide Tominaga, Hiroyoshi Imura and Hirofumi Yagi : スウェーデン製フィルムの検討, Oct. 1995.
95.	Masahide Tominaga, 福井義治, 福井壽人, 安友基勝, 天野雅史, 坂野啓一, 山田伸一, 団英司, 小濱義幸, Hiroyoshi Imura, Hirofumi Yagi, 藤田一彦 and 高島宏輔 : 新オルソタイプフィルムの検討(第2報), 日本放射線技術学会第36回中国·四国部会学術大会, Sep. 1995.
96.	天野雅史, 福井義治, 福井壽人, 安友基勝, Masahide Tominaga, 坂野啓一, 山田伸一, 団英司, 小濱義幸, Hiroyoshi Imura, Hirofumi Yagi, 藤田一彦 and 高島宏輔 : 新オルソタイプフィルムの検討(第1報), 日本放射線技術学会第36回中国·四国部会学術大会, Sep. 1995.
97.	荒井俊也, Hirofumi Yagi, Masahide Tominaga, 仁木敦志, 天野雅史, 高島宏輔, 安友基勝 and Hiroyoshi Imura : ADシステムの基礎的検討(第2報), 日本放射線技術学会第35,回中国·四国部会学術大会, Aug. 1994.
98.	Masahide Tominaga, 安友基勝, 天野雅史, 高島宏輔, Hiroyoshi Imura and Hirofumi Yagi : ADシステムの基礎的検討(第1報), 日本放射線技術学会第35回中国·四国部会学術大会, Aug. 1994.

Et cetera, Workshop:

1.	Yoshihiro Tanaka, Masahide Tominaga, Motoharu Sasaki, 廣田充宏, 鎌田真奈, Yasuo Hara, 坂東良太 and Hitoshi Ikushima : 三次元線量検出システムを用いたDVHに関する基礎的検討, 第26回高精度放射線治療研究会, Feb. 2013.
2.	Masahide Tominaga, Motoharu Sasaki, 磯部昇, Hitoshi Ikushima and 岸太郎 : 前立腺癌のIG-IMRTにおいてinter-fractional organ motion errorが線量分布に及ぼす影響, 第26回高精度放射線治療研究会, Feb. 2013.
3.	Masahide Tominaga : 放射線技師を中心とした放射線治療における品質管理の考え方と体制について, 放射線治療研究会雑誌, Vol.24, No.1, Nov. 2012.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Digital Archiving and its Use to Preserve Awa Ningyo Joruri for the Future (Project/Area Number: 23K11769 )
Development of radiosensitizers based on antitumor/molecular targeted drugs modified by acetylglucose (Project/Area Number: 26461891 )
Search by Researcher Number (90437632)

Associate Professor : Tominaga, Masahide

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Et cetera, Workshop:

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)