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Research Activity

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Field of Study

Medicine

Subject of Study

Elucidation of the pathogenesis of prion disease (prion, prion disease, neurodegeneration, Creutzfeldt-Jakob disease, mad cow disease)

Book / Paper

Book:

1. Suehiro Sakaguchi :
シンプル微生物学(編集:小熊恵二,堀田博,若宮伸隆),
Mar. 2018.
2. Keiji Uchiyama and Suehiro Sakaguchi :
Immunological strategies for the prevention and treatment of prion diseases.,
Caister Academic Press, Norfolk, UK, 2013.
3. Suehiro Sakaguchi :
44章スローウイルスとプリオン,
丸善出版, Tokyo, Oct. 2012.

Academic Paper (Judged Full Paper):

1. Keiji Uchiyama, Miyata Hironori, Yamaguchi Yoshitaka, Imamura Morikazu, Okazaki Mariya, Pasiana Dini Agriani, Junji Chida, Hideyuki Hara, Atarashi Ryuichiro, Watanabe Hitomi, Kondoh Gen and Suehiro Sakaguchi :
Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106.,
International Journal of Molecular Sciences, Vol.21, No.19, 7260, 2020.
(DOI: 10.3390/ijms21197260,   PubMed: 33019549,   Elsevier: Scopus)
2. Kishimoto Yasushi, Hirono Moritoshi, Atarashi Ryuichiro, Suehiro Sakaguchi, Yoshioka Tohru, Katamine Shigeru and Kirino Yutaka :
Impairment of cerebellar long-term depression and GABAergic transmission in prion protein deficient mice ectopically expressing PrPLP/Dpl.,
Scientific Reports, Vol.10, No.1, 15900, 2020.
(DOI: 10.1038/s41598-020-72753-6,   PubMed: 32985542,   Elsevier: Scopus)
3. Hideyuki Hara and Suehiro Sakaguchi :
N-terminal Regions of Prion Protein: Functions and Roles in Prion Diseases.,
International Journal of Molecular Sciences, Vol.21, No.17, E6233, 2020.
(DOI: 10.3390/ijms21176233,   PubMed: 32872280,   Elsevier: Scopus)
4. Junji Chida, Hideyuki Hara, Keiji Uchiyama, Etsuhisa Takahashi, Hironori Miyata, Hidetaka Kosako, Yukiko Tomioka, Toshihiro Ito, Hiroyuki Horiuchi, Haruo Matsuda, Hiroshi Kido and Suehiro Sakaguchi :
Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.,
PLoS Pathogens, Vol.16, No.8, e1008823, 2020.
(DOI: 10.1371/journal.ppat.1008823,   PubMed: 32845931)
5. Suehiro Sakaguchi and Junji Chida :
Prion Protein Is a Novel Modulator of Influenza: Its Potential Implications for Anti-Influenza Therapeutics.,
Current Issues in Molecular Biology, Vol.37, 21-32, 2019.
(DOI: 10.21775/cimb.037.021,   PubMed: 31814573,   Elsevier: Scopus)
6. Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Junji Chida, Keiji Uchiyama, Kentaro Masujin, Hitomi Watanabe, Gen Kondoh and Suehiro Sakaguchi :
The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region,
Molecular Neurobiology, Vol.57, 1203-1216, 2019.
(DOI: 10.1007/s12035-019-01804-5,   PubMed: 31707632,   Elsevier: Scopus)
7. Suehiro Sakaguchi and Junji Chida :
Roles of Prion Protein in Virus Infections.,
DNA and Cell Biology, Vol.37, No.10, 808-811, 2018.
(Tokushima University Institutional Repository: 112207,   DOI: 10.1089/dna.2018.4402,   PubMed: 30222366)
8. Junji Chida, Hideyuki Hara, Masashi Yano, Keiji Uchiyama, Rani Nandita Das, Etsuhisa Takahashi, Hironori Miyata, Yukiko Tomioka, Toshihiro Ito, Hiroshi Kido and Suehiro Sakaguchi :
Prion protein protects mice from lethal infection with influenza A viruses.,
PLoS Pathogens, Vol.14, No.5, e1007049, 2018.
(Tokushima University Institutional Repository: 112206,   DOI: 10.1371/journal.ppat.1007049,   PubMed: 29723291)
9. Luise Linsenmeier, Behnam Mohammadi, Sebastian Wetzel, Berta Puig, Walker S. Jackson, Alexander Hartmann, Keiji Uchiyama, Suehiro Sakaguchi, Kristina Endres, Jörg Tatzelt, Paul Saftig, Markus Glatzel and Hermann C. Altmeppen :
Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein.,
Molecular Neurodegeneration, Vol.13, No.1, 18, 2018.
(DOI: 10.1186/s13024-018-0248-6,   PubMed: 29625583,   Elsevier: Scopus)
10. Junji Chida and Suehiro Sakaguchi :
Cellular prion protein-mediated protection against influenza A virus infection.,
Future Virology, Vol.14, No.1, 31-37, 2018.
(Tokushima University Institutional Repository: 113067,   DOI: 10.2217/fvl-2018-0146)
11. Hideyuki Hara, Miyata Hironori, Das Rani Nandita, Junji Chida, Yoshimochi Tatenobu, Keiji Uchiyama, Watanabe Hitomi, Kondoh Gen, Yokoyama Takashi and Suehiro Sakaguchi :
Prion Protein Devoid of the Octapeptide Repeat Region Delays BSE Pathogenesis in Mice.,
Journal of Virology, Vol.92, No.1, pii:e01368-17, 2018.
(Tokushima University Institutional Repository: 111465,   DOI: 10.1128/JVI.01368-17,   PubMed: 29046443,   CiNii: 120006458155)
12. Suehiro Sakaguchi and Keiji Uchiyama :
Novel Amplification Mechanism of Prions through Disrupting Sortilin-Mediated Trafficking.,
Prion, Vol.11, No.6, 398-404, 2017.
(Tokushima University Institutional Repository: 112200,   DOI: 10.1080/19336896.2017.1391435,   PubMed: 29099278,   Elsevier: Scopus)
13. Keiji Uchiyama, Mitsuru Tomita, Masashi Yano, Junji Chida, Hideyuki Hara, Nandita Rani Das, Anders Nykjaer and Suehiro Sakaguchi :
Prions amplify through degradation of the VPS10P sorting receptor sortilin.,
PLoS Pathogens, Vol.13, No.6, e1006470, 2017.
(Tokushima University Institutional Repository: 110433,   DOI: 10.1371/journal.ppat.1006470,   PubMed: 28665987)
14. Das Rani Nandita, Miyata Hironori, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Watanabe Hitomi, Kondoh Gen and Suehiro Sakaguchi :
Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice.,
Archives of Virology, Vol.162, No.7, 1867-1876, 2017.
(Tokushima University Institutional Repository: 110119,   DOI: 10.1007/s00705-017-3295-3,   PubMed: 28255815,   Elsevier: Scopus)
15. Taichi Hamanaka, Keiko Nishizawa, Yuji Sakasegawa, Ayumi Oguma, Kenta Teruya, Hiroshi Kurahashi, Hideyuki Hara, Suehiro Sakaguchi and Katsumi Doh-ura :
Melanin or melanin-like substance interacts with the N-terminal portion of prion protein and inhibits abnormal prion protein formation in prion-infected cells.,
Journal of Virology, Vol.91, No.6, e01862-16, 2017.
(DOI: 10.1128/JVI.01862-16,   PubMed: 28077650)
16. Yuya Nagasawa, Yu Takahashi, Wataru Itani, Hitoshi Watanabe, Yusuke Hidaka, Shotaro Morita, Kei Suzuki, Kouichi Watanabe, Shyuichi Ohwada, Haruki Kitazawa, Morikazu Imamura, Takashi Yokoyama, Motohiro Horiuchi, Suehiro Sakaguchi, Shirou Mohri, Michael T. Rose, Tomonori Nochi and Hisashi Aso :
Prion Protein Binds to Aldolase A Produced by Bovine Intestinal M Cells.,
Open Journal of Veterinary Medicine, Vol.5, No.3, 43-60, 2015.
(DOI: 10.4236/ojvm.2015.53007)
17. Keiji Uchiyama, Miyata Hironori, Masashi Yano, Yoshitaka Yamaguti, Imamura Morikazu, Muramatsu Naomi, Das Rani Nandita, Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Mouse-Hamster Chimeric Prion Protein (PrP) Devoid of N-terminal Residues 23-88 Restores Susceptibility to 22L Prions, But Not to RML Prions in PrP-Knockout Mice.,
PLoS ONE, Vol.9, No.10, e109737, 2014.
(DOI: 10.1371/journal.pone.0109737,   PubMed: 25330286)
18. Keiji Uchiyama, Miyata Hironori and Suehiro Sakaguchi :
Disturbed vesicular trafficking of membrane proteins in prion disease.,
Prion, Vol.7, No.6, 447-451, 2013.
(DOI: 10.4161/pri.27381,   PubMed: 24335150,   Elsevier: Scopus)
19. Kishimoto Yaushi, Hirono Moritoshi, Atarashi Ryuichiro, Suehiro Sakaguchi, Yoshioka Tohru, Katamine Shigeru and Kirino Yutaka :
Age-dependent impairment of eyeblink conditioning in prion protein-deficient mice.,
PLoS ONE, Vol.8, No.4, e60627, 2013.
(DOI: 10.1371/journal.pone.0060627,   PubMed: 23593266,   CiNii: 120005289645)
20. Kimura Tsutomu, Sako Takeo, (名) Siqin, Hosokawa-Muto Junji, Cui Long Yi, Wada Yasuhiro, Kataoka Yosky, Doi Hisashi, Suehiro Sakaguchi, Suzuki Masaaki, Watanabe Yasuyoshi and Kuwata Kazuo :
Synthesis of an (11) C-labeled antiprion GN8 derivative and evaluation of its brain uptake by positron emission tomography.,
ChemMedChem, Vol.8, No.7, 1035-1039, 2013.
(DOI: 10.1002/cmdc.201300167,   PubMed: 23712919,   Elsevier: Scopus)
21. Keiji Uchiyama, Naomi Muramatsu, Masashi Yano, Takeshi Usui, Hironori Miyata and Suehiro Sakaguchi :
Prions disturb post-Golgi trafficking of membrane proteins.,
Nature Communications, Vol.4, 1846, 2013.
(DOI: 10.1038/ncomms2873,   PubMed: 23673631)
22. Yoshitaka Yamaguti, Hironori Miyata, Keiji Uchiyama, Akira Ootsuyama, Sachiko Inubushi, Tsuyoshi Mori, Naomi Muramatsu, Shigeru Katamine and Suehiro Sakaguchi :
Biological and biochemical characterization of mice expressing prion protein devoid of the octapeptide repeat region after infection with prions.,
PLoS ONE, Vol.7, No.8, e43540, 2012.
(DOI: 10.1371/journal.pone.0043540,   PubMed: 22927985)
23. Toshiya Kubota, Yuta Hamazoe, Shuhei Hashiguchi, Daisuke Ishibashi, Kazuyuki Akasaka, Noriyuki Nishida, Shigeru Katamine, Suehiro Sakaguchi, Ryota Kuroki, Toshihiro Nakashima and Kazuhisa Sugimura :
Direct evidence of generation and accumulation of -sheet-rich prion protein in scrapie-infected neuroblastoma cells with human IgG1 antibody specific for -form prion protein.,
The Journal of Biological Chemistry, Vol.287, No.17, 14023-14039, 2012.
(DOI: 10.1074/jbc.M111.318352,   PubMed: 22356913)
24. Ishibashi Daisuke, Yamanaka Hitoki, Tsuyoshi Mori, Yamaguchi Naohiro, Yoshitaka Yamaguti, Nishida Noriyuki and Suehiro Sakaguchi :
Antigenic mimicry-mediated anti-prion effects induced by bacterial enzyme succinylarginine dihydrolase in mice.,
Vaccine, Vol.29, No.50, 9321-9328, 2011.
(DOI: 10.1016/j.vaccine.2011.10.017,   PubMed: 22008817)
25. Ikuro Takakura, Kohtaro Miyazawa, Takashi Kanaya, Wataru Itani, Kouichi Watanabe, Shyuichi Ohwada, Hitoshi Watanabe, Tetsuya Hondo, T Michael Rose, Tsuyoshi Mori, Suehiro Sakaguchi, Noriyuki Nishida, Shigeru Katamine, Takahiro Yamaguchi and Hisashi Aso :
Orally administered prion protein is incorporated by m cells and spreads into lymphoid tissues with macrophages in prion protein knockout mice.,
The American Journal of Pathology, Vol.179, No.3, 1301-1309, 2011.
(DOI: 10.1016/j.ajpath.2011.05.058,   PubMed: 21763679)
26. Koji Fujita, Yoshitaka Yamaguchi, Tsuyoshi Mori, Naomi Muramatsu, Takahito Miyamoto, Masashi Yano, Hironori Miyata, Akira Ootsuyama, Makoto Sawada, Haruo Matsuda, Ryuji Kaji and Suehiro Sakaguchi :
Effects of a Brain-Engraftable Microglial Cell Line Expressing Anti-Prion scFv Antibodies on Survival Times of Mice Infected with Scrapie Prions.,
Cellular and Molecular Neurobiology, Vol.31, No.7, 999-1008, 2011.
(DOI: 10.1007/s10571-011-9696-z,   PubMed: 21516351)
27. Suehiro Sakaguchi, Daisuke Ishibashi and Haruo Matsuda :
Antibody-based immunotherapeutic attempts experimental animal models of prion diseases.,
Expert Opinion on Therapeutic Patents, Vol.19, No.7, 907-917, 2009.
(DOI: 10.1517/13543770902988530,   PubMed: 19514955)
28. Suehiro Sakaguchi :
Prospects for Preventative Vaccines against Prion Diseases,
Protein and Peptide Letters, Vol.16, No.3, 260-270, 2009.
(DOI: 10.2174/092986609787601804,   PubMed: 19275739)
29. Daisuke Yoshikawa, Naohiro Yamaguchi, Daisuke Ishibashi, Hitoki Yamanaka, Nobuhiko Okimura, Yoshitaka Yamaguti, Tsuyoshi Mori, Hironori Miyata, Kazuto Shigematsu, Shigeru Katamine and Suehiro Sakaguchi :
Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like protein/doppel in mice.,
The Journal of Biological Chemistry, Vol.283, No.35, 24202-24211, 2008.
(DOI: 10.1074/jbc.M804212200,   PubMed: 18562311)
30. Suehiro Sakaguchi :
Antagonistic roles of the N-terminal domain of prion protein to doppel,
Prion, Vol.2, No.3, 107-111, 2008.
(DOI: 10.4161/pri.2.3.7436,   PubMed: 19158506)
31. Y Nasu-Nishimura, Y Taniuchi, T Nishimura, A Sakudo, K Nakajima, Y Ano, K Sugiura, Suehiro Sakaguchi, S Itohara and T Onodera :
Cellular prion protein prevents brain damage after encephalomyocarditis virus infection in mice,
Archives of Virology, Vol.153, No.6, 1007-1012, 2008.
(DOI: 10.1007/s00705-008-0086-x,   PubMed: 18408883)
32. Suehiro Sakaguchi :
Recent developments in therapeutics for prion diseases,
Expert Opinion on Therapeutic Patents, Vol.18, No.1, 35-59, 2008.
(DOI: 10.1517/13543776.18.1.35)
33. Suehiro Sakaguchi :
Molecular biology of prion protein and its first homologous protein,
The Journal of Medical Investigation : JMI, Vol.54, No.3-4, 211-223, 2007.
(Tokushima University Institutional Repository: 111516,   DOI: 10.2152/jmi.54.211,   PubMed: 17878669)
34. CK Kim, A Sakudo, Y Taniuchi, K Shigematsu, CB Kang, K Saeki, Y Matsumoto, Suehiro Sakaguchi, S Itohara and T Onodera :
Late-onset olfactory deficits and mitral cell loss in mice lacking prion protein with ectopic expression of Doppel,
International Journal of Molecular Medicine, Vol.20, No.2, 169-176, 2007.
(DOI: 10.3892/ijmm.20.2.169,   PubMed: 17611634,   Elsevier: Scopus)
35. CK Kim, Y Hirose, A Sakudo, N Takeyama, CB Kang, Y Taniuchi, Y Matsumoto, S Itohara, Suehiro Sakaguchi and T Onodera :
Reduced response of splenocytes after mitogen-stimulation in the prion protein (PrP) gene-deficient mouse: PrPLP/Doppel production and cerebral degeneration,
Biochemical and Biophysical Research Communications, Vol.358, No.2, 469-474, 2007.
(DOI: 10.1016/j.bbrc.2007.04.174,   PubMed: 17498663)
36. Jiaxin Dong, Aimin Li, Naohiro Yamaguchi, Suehiro Sakaguchi and David A. Harris :
Doppel induces degeneration of cerebellar Purkinje cells independently of Bax,
The American Journal of Pathology, Vol.171, No.2, 599-607, 2007.
(DOI: 10.2353/ajpath.2007.070262,   PubMed: 17569776)
37. Nishimura Takuya, Sakudo Akikazu, Hashiyama Yoriko, Yachi Akiko, Saeki Keiichi, Matsumoto Yoshitsugu, Ogawa Masaharu, Suehiro Sakaguchi, Itohara Shigeyoshi and Onodera Takashi :
Serum withdrawal-induced apoptosis in ZrchI prion protein (PrP) gene-deficient neuronal cell line is suppressed by PrP, independent of Doppel,
Microbiology and Immunology, Vol.51, No.4, 457-466, 2007.
(PubMed: 17446686)
38. K Miyazawa, T Kanaya, S Tanaka, I Takakura, K Watanabe, S Ohwada, H Kitazawa, MT Rose, Suehiro Sakaguchi, S Katamine, T Yamaguchi and H Aso :
Immunohistochemical characterization of cell types expressing the cellular prion protein in the small intestine of cattle and mice,
Histochemistry and Cell Biology, Vol.127, No.3, 291-301, 2007.
(DOI: 10.1007/s00418-006-0250-x,   PubMed: 17165097)
39. Suehiro Sakaguchi and Arakawa Takeshi :
Recent developments in mucosal vaccines against prion diseases,
Expert Review of Vaccines, Vol.6, No.1, 75-85, 2007.
(DOI: 10.1586/14760584.6.1.75,   PubMed: 17280480)
40. Daisuke Ishibashi, Hitoki Yamanaka, Naohiro Yamaguchi, Daisuke Yoshikawa, Risa Nakamura, Nobuhiko Okimura, Yoshitaka Yamaguti, Kazuto Shigematsu, Shigeru Katamine and Suehiro Sakaguchi :
Immunization with recombinant bovine but not mouse prion protein delays the onset of disease in mice inoculated with a mouse-adapted prion,
Vaccine, Vol.25, No.6, 985-992, 2007.
(DOI: 10.1016/j.vaccine.2006.09.078,   PubMed: 17055125)
41. Yoshikawa Daisuke, Kopacek Juraj, Yamaguchi Naohiro, Ishibashi Daisuke, Yamanaka Hitoki, Yoshitaka Yamaguti, Katamine Shigeru and Suehiro Sakaguchi :
Newly established in vitro system with fluorescent proteins shows that abnormal expression of downstream prion protein-like protein in mice is probably due to functional disconnection between splicing and 3' formation of prion protein pre-mRNA,
Gene, Vol.386, No.1-2, 139-146, 2007.
(DOI: 10.1016/j.gene.2006.08.028,   PubMed: 17034959)
42. Satoshi Kawatake, Yuki Nishimura, Suehiro Sakaguchi, Toru Iwaki and Katsumi Doh-ura :
Surface plasmon resonance analysis for the screening of ant-prion compounds.,
Biological & Pharmaceutical Bulletin, Vol.29, No.5, 927-932, 2006.
(DOI: 10.1248/bpb.29.927,   PubMed: 16651721)
43. Hitoki Yamanaka, Daisuke Ishibashi, Naohiro Yamaguchi, Daisuke Yoshikawa, Risa Nakamura, Nobuhiko Okimura, Takeshi Arakawa, Takao Tsuji, Shigeru Katamine and Suehiro Sakaguchi :
Enhanced mucosal immunogenicity of prion protein following fusion with B subunit of Escherichia coli heat-labile enterotoxin.,
Vaccine, Vol.24, No.15, 2815-2823, 2006.
(DOI: 10.1016/j.vaccine.2005.12.054,   PubMed: 16446015)
44. Yasuko Sakurai-Yamashita, Suehiro Sakaguchi, Daisuke Yoshikawa, Nobuhiko Okimura, Yoshiko Masuda, Shigeru Katamine and Masami Niwa :
Female-specific neuroprotection against transient brain ischemia observed in mice devoid of prion protein is abolished by ectopic expression of prion protein-like protein.,
Neuroscience, Vol.136, No.1, 281-287, 2005.
(DOI: 10.1016/j.neuroscience.2005.06.095,   PubMed: 16198494)
45. Kazuhiko Arima, Noriyuki Nishida, Suehiro Sakaguchi, Kazuto Shigematsu, Ryuichiro Atarashi, Naohiro Yamaguchi, Daisuke Yoshikawa, Jaewoo Yoon, Ken Watanabe, Nobuyuki Kobayashi, Sophie Mouillet-Richard, Sylvain Lehmann and Shigeru Katamine :
Biological and biochemical characteristics of prion strains conserved in persistently-infected cell cultures.,
Journal of Virology, Vol.79, No.11, 7104-7112, 2005.
(DOI: 10.1128/JVI.79.11.7104-7112.2005,   PubMed: 15890950)
46. Suehiro Sakaguchi :
Prion protein, prion protein-like protein, and neurodegeneration.,
Neurodegeneration and Prion Disease edited by David R. Brown, 167-193, 2005.
(DOI: 10.1007/0-387-23923-5_7,   Elsevier: Scopus)
47. Takuya Nishimura, Akikazu Sakudo, Izuru Nakamura, Deug-chan Lee, Yoichiro Taniuchi, Keiichi Saeki, Yoshitsugu Matsumoto, Masaharu Ogawa, Suehiro Sakaguchi, Shigeyoshi Itohara and Takashi Onodera :
Cellular prion protein regulates intracellular hydrogen peroxide level and prevents copper-induced apoptosis.,
Biochemical and Biophysical Research Communications, Vol.323, No.1, 218-222, 2004.
(DOI: 10.1016/j.bbrc.2004.08.087,   PubMed: 15351724)
48. Naohiro Yamaguchi, Suehiro Sakaguchi, Kazuto Shigematsu, Nobuhiko Okimura and Shigeru Katamine :
Doppel-induced Purkinje cell death is stoichiometrically abrogated by prion protein.,
Biochemical and Biophysical Research Communications, Vol.319, No.4, 1247-1252, 2004.
(DOI: 10.1016/j.bbrc.2004.05.115,   PubMed: 15194501,   CiNii: 30017808163)
49. Akikazu Sakudo, Deug-chan Lee, Etsuro Yoshimura, Seiji Nagasaka, Kayako Nitta, Keiichi Saeki, Yoshitsugu Matsumoto, Sylvain Lehmann, Shigeyoshi Itohara, Suehiro Sakaguchi and Takashi Onodera :
Prion protein suppresses perturbation of cellular copper homeostasis under oxidative conditions.,
Biochemical and Biophysical Research Communications, Vol.313, No.4, 850-855, 2004.
(DOI: 10.1016/j.bbrc.2003.12.020,   PubMed: 14706620)
50. Suehiro Sakaguchi :
Antagonistic roles of prion protein and prion protein-like protein in neurodegeneration.,
Recent Research Developments in Experimental Medicine, Vol.1, 47-61, 2004.
51. Ryuichiro Atarashi, Suehiro Sakaguchi, Kazuto Shigematsu and Shigeru Katamine :
The absence of prion-like infectivity in mice expressing prion protein-like protein.,
EXCLI Journal, Vol.3, 82-90, 2004.
52. Masahisa Watarai, Suk Kim, Janchivdorj Erdenebaatar, Sou-ichi Makino, Motohiro Horiuchi, Toshikazu Shirahata, Suehiro Sakaguchi and Shigeru Katamine :
Cellular prion protein promotes Brucella infection into macrophages.,
The Journal of Experimental Medicine, Vol.198, No.1, 5-17, 2003.
(DOI: 10.1084/jem.20021980,   PubMed: 12847134)
53. Ryuichiro Atarashi, Noriyuki Nishida, Kazuto Shigematsu, Shinji Goto, Takahito Kondo, Suehiro Sakaguchi and Shigeru Katamine :
Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/Doppel-induced neurodegeneration.,
The Journal of Biological Chemistry, Vol.278, No.31, 28944-28949, 2003.
(DOI: 10.1074/jbc.M303655200,   PubMed: 12759361)
54. Ryuichiro Atarashi, Suehiro Sakaguchi, Kazuto Shigematsu, Kazuhiko Arima, Nobuhiko Okimura, Naohiro Yamaguchi, A Li, Juraj Kopacek and Shigeru Katamine :
Abnormal activation of glial cells in the brains of prion protein-deficient mice ectopically expressing prion protein-like protein, PrPLP/Dpl.,
Molecular Medicine, Vol.7, No.12, 803-809, 2001.
(PubMed: 11844868)
55. Paolo Valenti, Antonio Cozzio, Noriyuki Nishida, David P. Wolfer, Suehiro Sakaguchi and Hans-Peter Lipp :
Similar target, different effects: late-onset ataxia and spatial learning in prion protein-deficient mouse lines.,
Neurogenetics, Vol.3, No.4, 173-184, 2001.
(DOI: 10.1007/s100480100117,   PubMed: 11714097)
56. Ryota Nakaoke, Suehiro Sakaguchi, Ryuichiro Atarashi, Noriuki Nishida, Kazuhiko Arima, Kazuto Shigematsu and Shigeru Katamine :
Early appearance but lagged accumulation of detergent-insoluble prion protein in the brains of mice inoculated with a mouse-adapted Creutzfeldt-Jakob disease agent.,
Cellular and Molecular Neurobiology, Vol.20, No.6, 717-730, 2000.
(DOI: 10.1023/A:1007054909662,   PubMed: 11100979,   Elsevier: Scopus)
57. Aimin Li, Suehiro Sakaguchi, Kazuto Shigematsu, Ryuichiro Atarashi, Bhabesh C. Roy, Ryota Nakaoke, Kazuhiko Arima, Nobuhiko Okimura, Juraj Kopacek and Shigeru Katamine :
Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons of PrP-deficient mice ataxic due to Purkinje cell degeneration.,
The American Journal of Pathology, Vol.157, No.5, 1447-1452, 2000.
(DOI: 10.1016/S0002-9440(10)64782-7,   PubMed: 11073804,   Elsevier: Scopus)
58. Aimin Li, Suehiro Sakaguchi, Ryuichiro Atarashi, Bhabesh C. Roy, Ryota Nakaoke, Kazuhiko Arima, Nobuhiko Okimura, Juraj Kopacek and Kazuto Shigematsu :
Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene.,
Cellular and Molecular Neurobiology, Vol.20, No.5, 553-567, 2000.
(DOI: 10.1023/A:1007059827541,   PubMed: 10930132,   Elsevier: Scopus)
59. Juraj Kopacek, Suehiro Sakaguchi, Kazuto Shigematsu, Noriyuki Nishida, Ryuichiro Atarashi, Ryota Nakaoke, Ryozo Moriuchi, Masami Niwa and Shigeru Katamine :
Upregulation of the genes encoding lysosomal hydrolases, a perforin-like protein, and peroxidases in the brains of mice affected with an experimental prion disease.,
Journal of Virology, Vol.74, No.1, 411-417, 2000.
(PubMed: 10590130,   Elsevier: Scopus)
60. Maria A. Deli, Suehiro Sakaguchi, Ryota Nakaoke, Csongor S. Abraham, Hideaki Takahata, Juraj Kopacek, Kazuto Shigematsu, Shigeru Katamine and Masami Niwa :
PrP fragment 106-126 is toxic to cerebral endothelial cells expressing PrPC.,
NeuroReport, Vol.11, No.17, 3931-3936, 2000.
(DOI: 10.1097/00001756-200011270-00064)
61. Noriyuki Nishida, Patrick Tremblay, Tetsuo Sugimoto, Kazuto Shigematsu, Susumu Shirabe, Chris Petromilli, Susanne Pilkuhn Erpel, Ryota Nakaoke, Ryuichiro Atarashi, Takeshi Houtani, Marilyn Torchia, Suehiro Sakaguchi, Stephen J. DeArmond, Stanley B. Prusiner and Shigeru Katamine :
A mouse prion protein (PrP) transgene rescues Purkinje cell degeneration and demyelination in mice deficient for PrP.,
Laboratory Investigation, Vol.79, No.6, 689-697, 1999.
62. Shigeru Katamine, Noriuki Nishida, Tetsuo Sugimoto, Tetsuo Noda, Suehiro Sakaguchi, Kazuto Shigematsu, Yasufumi Kataoka, Akira Nakatani, Sumitaka Hasegawa, Ryozo Moriuchi and Tsutomu Miyamoto :
Impaired motor coordination in mice lacking prion protein.,
Cellular and Molecular Neurobiology, Vol.18, No.6, 731-742, 1998.
(PubMed: 9876879)
63. Suehiro Sakaguchi, Shigeru Katamine, Noriyuki Nishida, Ryozo Moriuchi, Kazuto Shigematsu, Tetsuo Sugimoto, Akira Nakatani, Yasufumi Kataoka, Takeshi Houtani, Susumu Shirabe, Hitoshi Okada, Sumitaka Hasegawa, Tsutomu Miyamoto and Tetsuo Noda :
Loss of cerebellar Purkinje cells in aged mice homozygous for a disrupted PrP gene.,
Nature, Vol.380, No.6574, 528-531, 1996.
(DOI: 10.1038/380528a0,   PubMed: 8606772)
64. Suehiro Sakaguchi, Shigeru Katamine, Kazuto Shigematsu, Akira Nakatani, Ryozo Moriuchi, Noriyuki Nishida, Kenji Kurokawa, Ryota Nakaoke, Hiroshi Sato, Kouichi Jishage, Junko Kuno, Tetsuo Noda and Tsutomu Miyamoto :
Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent.,
Journal of Virology, Vol.69, No.12, 7586-7592, 1995.
65. Tsutomu Miyamoto, Suehiro Sakaguchi, Shigeru Katamine and Ryozo Moriuchi :
The infectivity is dissociated from PrP accumulation in salivary gland of Creutzfeldt-Jakob disease agent-inoculated mice.,
Annals of the New York Academy of Sciences, Vol.724, 310-313, 1994.
66. Suehiro Sakaguchi, Shigeru Katamine, Kouichi Yamanouchi, Masao Kishikawa, Ryozo Moriuchi, Norio Yasukawa, Takashi Doi and Tsutomu Miyamoto :
Kinetics of infectivity are dissociated from PrP accumulation in salivary glands of Creutzfeldt-Jakob disease agent-inoculated mice.,
The Journal of General Virology, Vol.74, No.Pt10, 2117-2123, 1993.
(DOI: 10.1099/0022-1317-74-10-2117,   PubMed: 8409936)

Review, Commentary:

1. Junji Chida, Hiroshi Kido and Suehiro Sakaguchi :
宿主因子を標的にした新たなインフルエンザ治療の試み,
BIO Clinica, Vol.256, No.33, 52-55, Feb. 2018.
2. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン病における神経変性のメカニズム,
Clinical Neuroscience, Vol.31, No.9, 1022-1024, Sep. 2013.
3. Suehiro Sakaguchi and Tsuyoshi Mori :
プリオン病,
Clinical Neuroscience, Vol.28, No.8, 906-908, Aug. 2010.
4. Suehiro Sakaguchi :
プリオン蛋白異常化と伝達・進行のメカニズム,
プリオン病と遅発性ウイルス感染症, 37-43, Jul. 2010.
5. Suehiro Sakaguchi :
プリオン病予防ワクチンの開発の試み,
バイオ医薬の開発技術とシリーズ, 373-384, Mar. 2009.
6. Suehiro Sakaguchi :
プリオン病と治療戦略の最近の動向,
BRAIN and NERVE, Vol.61, No.8, 929-938, 2009.
7. Suehiro Sakaguchi :
基礎医学研究の活性化を目指して-若手研究者の育成:今後求められるもの-,
Shikoku Acta Medica, Vol.64, No.1,2, 7-9, 2008.
(Tokushima University Institutional Repository: 110215)
8. Suehiro Sakaguchi :
Physiological functions of prion protein and its roles in the pathogenesis of prion diseases,
Seikagaku, Vol.79, No.9, 843-852, Sep. 2007.
(PubMed: 17969324,   CiNii: 10019948867,   Elsevier: Scopus)
9. Suehiro Sakaguchi :
プリオン伝播(プリオン蛋白異常化)のメカニズム,
Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.65, No.8, 1391-1395, Aug. 2007.
10. Suehiro Sakaguchi :
プリオン蛋白質の生理機能,
Antibiotics and Chemotherapy, Vol.22, No.1, 56-62, Jan. 2006.
11. Suehiro Sakaguchi :
プリオン病,
感染症 The infection, Vol.36, No.4, 9-13, 2006.
12. Suehiro Sakaguchi :
プリオン蛋白とプリオン病,
Current Concepts in Infectious Diseases 対談:感染症-今日の話題から, Vol.24, No.3, 3-5, 2005.
13. Suehiro Sakaguchi :
プリオン蛋白類似分子の分子生物学-第2のプリオン蛋白とは-,
Journal of Clinical and Experimental Medicine, Vol.203, No.10, 871-876, Dec. 2002.
14. Suehiro Sakaguchi and 片峰 茂 :
正常プリオンタンパクの働き,
ファルマシア, Vol.38, No.7, 640-644, 2002.
15. Suehiro Sakaguchi :
プリオン -プリオン研究の現状と将来の展望—,
ウイルス, Vol.52, No.1, 163-167, 2002.
16. Suehiro Sakaguchi :
クロイツフェルト・ヤコブ病の治療,
臨床検査, Vol.46, No.12, 1527-1532, 2002.
17. Suehiro Sakaguchi and 片峰 茂 :
ノックアウトマウスとプリオン病,
Clinical Neuroscience, Vol.19, No.8, 36(898)-39(901), 2001.
18. Suehiro Sakaguchi and 片峰 茂 :
Doppel(Dpl)/PrPLP,
脳の科学, Vol.22, 718-719, 2000.
19. Suehiro Sakaguchi and 片峰 茂 :
プリオン病とプリオン蛋白,
感染,炎症,免疫, Vol.30, No.4, 2(272)-11(281), 2000.
20. Suehiro Sakaguchi and 片峰 茂 :
プリオン病の分子病態,
遺伝子医学, Vol.3, 103(321)-107(325), 1999.
21. Suehiro Sakaguchi and 片峰 茂 :
プリオン病の分子生物学,
ウイルス, Vol.49, No.2, 193-204, 1999.
22. Suehiro Sakaguchi and 片峰 茂 :
遺伝子操作マウスによるプリオン病の研究,
New Horizon for Medicine, Vol.29, No.12, 87(3133)-91(3137), 1997.
23. 新 竜一朗 and Suehiro Sakaguchi :
プリオンの分子生物学,
Brain Medical, Vol.9, No.3, 33(249)-38(254), 1997.
24. Suehiro Sakaguchi and 宮本 勉 :
プリオン病 —概念,疾患,動向—,
小児科診療, Vol.60, No.11, 1771(61)-1776(66), 1997.
25. Suehiro Sakaguchi and 片峰 茂 :
ノックアウトマウスによるプリオンの解析,
実験医学, Vol.14, No.18, 43(2525)-47(2529), 1996.
26. Suehiro Sakaguchi and 宮本 勉 :
クロイツフェルト-ヤコブ病の成因とプリオン,
老年期痴呆, Vol.7, No.3, 31(303)-36(308), 1993.

Proceeding of International Conference:

1. Keiji Uchiyama and Suehiro Sakaguchi :
Sorting of prion protein and PrPSc accumulation.,
International Prion Congress-Prion 2016, Tokyo, May 2016.
2. Keiji Uchiyama, Tomita Mitsuru and Suehiro Sakaguchi :
Mechanism of sortilin-mediated PrP degradation.,
Asian Pacific Prion Symposium 2015, Ishikawa Ongakudo, Kanazawa, Japan., Sep. 2015.
3. Tomita Mitsuru, Keiji Uchiyama, Usui Takeshi and Suehiro Sakaguchi :
Analysis of roles of N-terminal region of prion protein in the conversion into scrapie form by using prion-knockout cell.,
Asian Pacific Prion Symposium 2015, Ishikawa Ongakudo, Kanazawa, Japan, Sep. 2015.
4. Suehiro Sakaguchi :
Vesicular trafficking in prion disease,
Asian Pacific Prion Symposium 2014, Jul. 2014.
5. Keiji Uchiyama and Suehiro Sakaguchi :
Post-Golgi trafficking of membrane proteins impaired by prion infection.,
Prion, Vol.8, 98, Trieste, Italy, Jun. 2014.
6. Keiji Uchiyama and Suehiro Sakaguchi :
Prions disturb post-Golgi membrane trafficking to the cell surface.,
Proceedings of The 9th International Symposium of the Institute Network, 30, Osaka, Jun. 2014.
7. Suehiro Sakaguchi and Keiji Uchiyama :
Prions impair post-Golgi trafficking of membrane proteins,
Asian Pacific Prion Symposium 2013, Nagasaki, Jul. 2013.
8. Suehiro Sakaguchi :
The role of the N-terminal region of prion protein in prion disease.,
8th IBRO World Congress of Neuroscience International Brain Research Organization, Florence Italy, Jul. 2011.
9. Suehiro Sakaguchi :
Effects of a deletion of the N-terminal part of prion protein on prion replication and pathogenesis in mice,
PRION JAPAN & CANADA Foregoing partnerships. Advancing prion research. U-Port Hotel, Shinagawa, Tokyo, Japan., Nov. 2010.
10. Suehiro Sakaguchi, Miyata Hironori, Yoshitaka Yamaguti, Tsuyoshi Mori and Muramatsu Naomi :
Roles of the N-terminal region of prion protein in prion propagation and pathogenesis,
Asia-Oceania Symposium on Prion Diseases (AOSPD 2010), Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan., Sapporo, Jul. 2010.
11. Suehiro Sakaguchi :
Antagonistic interaction between prion protein and its homologue, PrPLP/Dpl, in neurodegeneration,
AACL-Nagasaki Symposium, ASIAN AGING 2006: The Regional Aging Connection and the Future, Nagasaki, Japan, Jun. 2006.
12. Suehiro Sakaguchi :
Prion protein and prion diseases,
2005 Japan-America Frontiers of Engineering Symposium, San Jose, USA, Nov. 2005.
13. Suehiro Sakaguchi, D Ishibashi and H Yamanaka :
Efficient Induction of Prophylactic antibodies against Prion Disease in Mice,
24th International Congress of Chemotherapy. Symposium 34: Emerging and re-emerging infectious diseases in the Western Pacific, Manila, Philippine, Jun. 2005.
14. S Hashiguchi, S Kitamoto, K Sakamoto, Y Ito, T Nakashima, K Sasaki, JU Gaikwad, K Akasaka, Suehiro Sakaguchi, S Katamine and K Sugimura :
Human antibodies specific to beta-sheet-rich isoform of human prion protein,
PEGS: The Protein Engineering Summit, ``Take Protein Engineering from Concept to Reality'', Cambridge, Massachusetts, USA, May 2005.
15. S Hashiguchi, M Yamamoto, S Kitamoto, T Nakashima, H Yamanaka, D Ishibashi, Suehiro Sakaguchi, S Katamine, Y Ito and K Sugimura :
Prion-conformation-specific human antibodies established from phage display library,
International Symposium, Prion Diseases, Food and Drug safety, Sendai, 2004.
16. H Yamanaka, D Ishibashi, T Tsuji and Suehiro Sakaguchi :
Mucosal immuneogenicity of prion protein fused with heat-labile enterotoxin B subunit,
International Symposium, Prion Diseases, Food and Drug safety, Sendai, Japan, 2004.
17. Suehiro Sakaguchi :
Roles of PrP and PrP-lik proteins (Doppel) in neurodegeneration,
Keystone Symposium, Molecular Aspects of Transmissible Spongiform Encephalopathies (Prion Diseases), Colorado, USA, 2003.
18. K Arima, N Nishida, Suehiro Sakaguchi, S Lehmann and S Katamine :
The strain diversity of the TSE agent in cell-culture models,
International Conference on Transmissible Spongiform Encephalopathies, Edinburgh, UK, 2002.
19. Suehiro Sakaguchi, R Atarashi, K Shigematsu and S Katamine :
Evaluation of pathogenic roles of PrPLP/Dpl in prion diseases,
International Symposium on The New Prion Biology: Basic Science, Diagnosis and Therapy, Venezia, Italy, 2002.
20. Y Kirino, Y Kishimoto, S Kawahara, T Nakaya, Suehiro Sakaguchi and S Katamine :
Age-dependent Disturbance of Delay Eyeblink Conditioning in Prion Protein-Deficient Mice,
Society for Neuroscience, Annual Meeting, Miami Beach, Florida, Oct. 1999.
21. S Katamine, J Kopacek, Suehiro Sakaguchi, R Atarshi, R Nakaoke, A Li, M Niwa and K Shigematsu :
Upregulation of the genes encoding lysosomal hydrolases and a perforin-like protein in microglia colocalyzed with vacuolar neurodegeneration in the brain of mice affected with an experimental prion disease,
Characterization and Diagnosis of Prion Diseases in Animal and Man, Tueingen, Germany, 1999.
22. N Nishida, Suehiro Sakaguchi, R Nakaoke, R Atarashi, A Nakatani, K Shigematsu, S Shirabe, T Sugimoto, P Tremblay, SB Prusiner and S Katamine :
Purkinje cell loss in the PrP-gene knockout mouse is rescued by a wild-type mouse PrP-transgene,
Conferences Philippe Laudat INSERM Molecular Mechanisms of Infection and Pathology in Prion Diseases, Domaine Aix-Marlioz, Aix-les-Bains, France, Oct. 1997.
23. S Katmine, Suehiro Sakaguchi, N Nishida, R Moriuchi, K Shigematsu, A Nakatani, Y Kataoka, T Sugimoto, T Noda and T Miyamoto :
Loss of cerebellar Purkinje neurons in aged mice homozygous for disrupted PrP gene,
International Symposium: Prion diseases, Epidemiology, Biochemistry, and Molecular Biology, Goettingen, Germany, Nov. 1995.
24. S Katamine, Suehiro Sakaguchi, N Nishida, R Moriuchi, K Shigematsu, A Nakatani, Y Kataoka, T Sugimoto, T Noda and T Miyamoto :
Impaired motor coordination and loss of cerebellar Purkinje cells in aged mice homozygous for disrupted PrP gene,
Satellite Symposium of the 15th International Society of Neurochemistry and 7th International Symposium of the Biochemistry and Biophysics on Diagnosis and Treatment of Stroke, Neurotrauma, and Other Neurological Diseases, Kurashiki, Japan, 1995.

Proceeding of Domestic Conference:

1. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
プリオン蛋白質はインフルエンザ A ウイルス感染による重症化を軽減する,
第42回日本分子生物学会年会, Dec. 2019.
2. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
ウイルス感染を用いたプリオン病発症機構の解明,
第42回日本分子生物学会年会, Dec. 2019.
3. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
Influenza virus infection triggers de novo generation of prions in neuronal cells,
第41回日本分子生物学会年会, Nov. 2018.
4. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Prion protein provides a protection against influenza A virus infection,
第66回日本ウイルス学会学術集会, Oct. 2018.
5. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Prion protein protects mice from lethal infection with Influenza A virues,
2017年度生命科学系学会合同年次大会 (ConBio2017) 第 40回日本分子生物学会年会/第90回日本 生化学会大会, Dec. 2017.
6. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
Prion-infected neuroblastoma cells are resistant to influenza virus.,
2017年度生命科学系学会合同年次大会 (ConBio2017) 第 40回日本分子生物学会年会/第90回日本 生化学会大会, Dec. 2017.
7. Keiji Uchiyama and Suehiro Sakaguchi :
Identification and investigation of a novel anti-prion compound.,
第65回日本ウイルス学会学術集会, Oct. 2017.
8. Keiji Uchiyama, Tomohiro Tohkoh and Suehiro Sakaguchi :
High susceptibility of Sortilin-deficient cells to prion infection.,
第65回日本ウイルス学会学術集会, Oct. 2017.
9. Suehiro Sakaguchi and Keiji Uchiyama :
Prion propagation through sortilin degradation.,
第60回日本神経化学会大会, Sep. 2017.
10. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
蛋白質凝集体「プリオン」による抗インフルエンザウイルス活性機構の解明,
第39回日本分子生物学会年会, Dec. 2016.
11. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン病における異常プリオンの蓄積メカニズム,
第39回日本分子生物学会, Dec. 2016.
12. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
蛋白質凝集体「プリオン」による抗インフルエンザウイルス活性機構の解明,
第39回日本分子生物学会年会, Dec. 2016.
13. Suehiro Sakaguchi :
プリオンの神経毒性及び複製メカニズム.,
徳島大学大学院医歯薬学研究部 2015年度 第7回脳科学クラスター・ミニリトリート, Feb. 2016.
14. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
蛋白質凝集体「プリオン」による抗インフルエンザ活性の発見,
第38回日本分子生物学会年会 第88回日本生化学会大会合同大会, Dec. 2015.
15. Keiji Uchiyama, 富田 満 and Suehiro Sakaguchi :
プリオン感染により過剰な異常プリオンが蓄積する分子メカニズム,
第38回に本分子生物学会年会 第88回日本生化学会大会合同大会, Dec. 2015.
16. Keiji Uchiyama, 富田 満 and Suehiro Sakaguchi :
Inhibition of Sortilin-mediated PrP degradation by prion infection causes excessive accumulation of abnormal prion protein.,
第63回日本ウイルス学会学術集会, Nov. 2015.
17. Keiji Uchiyama, 富田 満 and Suehiro Sakaguchi :
Novel molecular mechanism for accumulation of abnormal prion protein - Inhibition of Sortilin-mediated PrP degradation.,
第15回蛋白質科学会年会ワークショップ 「New development of prion biology」, Jun. 2015.
18. Suehiro Sakaguchi and Keiji Uchiyama :
プリオンによるポストゴルジ膜輸送障害,
第36回生体膜と薬物の相互作用シンポジウム「生体膜における蛋白質の機能制御システムと疾患」, Nov. 2014.
19. 富田 満, Keiji Uchiyama, 臼井 健 and Suehiro Sakaguchi :
プリオンノックアウト細胞を用いたプリオンタンパク質N末端領域の異常プリオン形成における役割の解明,
第62回日本ウイルス学会学術集会, Nov. 2014.
20. Keiji Uchiyama, 富田 満, 臼井 健 and Suehiro Sakaguchi :
新規プリオン結合因子Sortilinのプリオン感染における役割,
第62回日本ウイルス学会学術集会, Nov. 2014.
21. 清水 七海, 古賀 雄一, 作道 章一, Hideyuki Hara, Suehiro Sakaguchi and 金谷 茂則 :
超好熱菌由来プロテアーゼによるプリオンタンパク質分解の評価,
第87回日本生化学会, Oct. 2014.
22. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染と小胞輸送障害,
第87回日本生化学会 シンポジウム 認知症克服に向けて:プリオン病をもっと知る., Oct. 2014.
23. Suehiro Sakaguchi :
プリオン病のイントロダクション,
第87回日本生化学会 シンポジウム 認知症克服に向けて:プリオン病をもっと知る, Oct. 2014.
24. 古賀 雄一, 清水 七海, 作道 章一, Hideyuki Hara, Suehiro Sakaguchi and 金谷 茂則 :
超好熱菌由来プロテアーゼによるプリオンタンパク質分解の評価,
第66回日本生物工学会大会, Sep. 2014.
25. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染によるSortilin発現低下が異常プリオン蓄積を引き起こす,
第29回中国四国ウイルス研究会プログラム・抄録集, 26, Jun. 2014.
26. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染によるポストゴルジ小胞輸送障害,
第66回日本細胞生物学会要旨集, 149, Jun. 2014.
27. 村松 直美 and Suehiro Sakaguchi :
プロテアソーム阻害はプリオン感染細胞においてG2期停止を引き起こしアポトーシスを増悪させる,
第61回日本ウイルス学会学術集会, Nov. 2013.
28. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染はポストゴルジ小胞輸送を抑制する,
第61回日本ウイルス学会学術集会, Nov. 2013.
29. 村松 直美 and Suehiro Sakaguchi :
Enhanced apoptosis and G2 arrest in prion-infected cells treated with proteasome inhibitors,
日本生化学会, Sep. 2013.
30. Keiji Uchiyama and Suehiro Sakaguchi :
Prions impair post-Golgi trafficking of membrane proteins,
日本生化学会, Sep. 2013.
31. Suehiro Sakaguchi and Keiji Uchiyama :
Inhibition of Post-Golgi Membrane Traffic in Prion-Infected Cells,
第35回分子生物学会年会(ポスター発表), Dec. 2012.
32. Suehiro Sakaguchi and Keiji Uchiyama :
Inhibition of Post-Golgi Membrane Traffic in Prion-Infected Cells,
第35回分子生物学会年会 ワークショップ「Membrane Traccic and Diseases」(口頭発表), Dec. 2012.
33. Ishibashi Daisuke, Yamanaka Hitoki, Yamaguchi Naohiro, Yoshitaka Yamaguti, Nishida Noriyuki and Suehiro Sakaguchi :
細菌由来の蛋白succinylarginine dihydrolaseの免疫によるプリオン病の予防効果,
第40回日本免疫学会, Nov. 2011.
34. Tsuyoshi Mori, 村松 直美, Sachiko Inubushi, Yoshitaka Yamaguti, Masashi Yano, Koji Fujita and Suehiro Sakaguchi :
プリオン蛋白過剰発現誘導性細胞死の分子機構,
第33回日本分子生物学会年会,第83回日本生化学会大会合同大会, Dec. 2010.
35. Suehiro Sakaguchi, 宮田 博規, Yoshitaka Yamaguti, 村松 直美 and Tsuyoshi Mori :
異なるプリオン株の産生メカニズム,
第33回日本分子生物学会年会,第83回日本生化学会大会合同大会, Dec. 2010.
36. Tsuyoshi Mori, 村松 直美, Sachiko Inubushi, Yoshitaka Yamaguti, Masashi Yano, Koji Fujita and Suehiro Sakaguchi :
プリオン蛋白過剰発現誘導性細胞死の分子機構,
第33回日本分子生物学会年会,第83回日本生化学会大会合同大会 プリオン蛋白過剰発現誘導性細胞死の分子機構 神戸ポートアイランド, Dec. 2010.
37. 村松 直美, Tsuyoshi Mori, Yoshitaka Yamaguti, Koji Fujita and Suehiro Sakaguchi :
A prion protein with familial mutation, PrP-Y145Stop, induces cell death through G2 cell cycle arrest,
第33回日本分子生物学会年会,第83回日本生化学会大会合同大会 神戸ポートアイランド, Dec. 2010.
38. 清水 一史, 佐々木 裕, 芝田 敏克, 田中 寅彦, 黒田 和道, Suehiro Sakaguchi, 片峰 茂 and 山本 樹生 :
インフルエンザウイルス感染による選択的スプライシングの誘導,
第58回日本ウイルス学会 あわぎんホール(徳島県郷土文化会館), Nov. 2010.
39. 村松 直美, Tsuyoshi Mori, Yoshitaka Yamaguti and Suehiro Sakaguchi :
培養細胞を用いたプリオンの細胞死誘導のメカニズム,
第58回日本ウイルス学会 あわぎんホール(徳島県郷土文化会館), Nov. 2010.
40. Tsuyoshi Mori, 村松 直美, Sachiko Inubushi, Yoshitaka Yamaguti and Suehiro Sakaguchi :
プリオン蛋白の過剰発現は細胞死を誘導する,
第58回日本ウイルス学会 あわぎんホール(徳島県郷土文化会館), Nov. 2010.
41. Yoshitaka Yamaguti, 村松 直美, Tsuyoshi Mori and Suehiro Sakaguchi :
プリオン蛋白構造変換におけるアミノ酸91-104領域の役割,
第58回日本ウイルス学会, Nov. 2010.
42. Suehiro Sakaguchi, 宮田 博規, Yoshitaka Yamaguti, 村松 直美 and Tsuyoshi Mori :
異なるプリオン株に異なる感受性を示すプリオン蛋白:プリオン株産生メカニズムについての考察,
第58回日本ウイルス学会 あわぎんホール(徳島県郷土文化会館), Nov. 2010.
43. Suehiro Sakaguchi :
感染性タンパク質``プリオン'',
第一回全国共同利用・共同研究「酵素学研究拠点」シンポジウム—酵素学から始まる新たな創薬研究—, Sep. 2010.

Et cetera, Workshop:

1. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
肺で発現する正常プリオン蛋白質の機能解析,
第32回中国四国ウイルス研究会, Jun. 2017.
2. Suehiro Sakaguchi :
プリオン病の分子生物学,
徳島文理大学薬学部病態分子薬理学研究室大学院特別講義, Dec. 2016.
3. Suehiro Sakaguchi :
次世代抗インフルエンザ薬の宿主ターゲット分子の発見とその治療効果,
四国地区五大学 新技術説明会, Nov. 2015.
4. Suehiro Sakaguchi :
プリオン病におけるポストゴルジ小胞輸送障害,
革新的医療研究開発で挑む神経変性疾患—プリオン病治験耐性の確立に向けてー, Feb. 2015.
5. Suehiro Sakaguchi :
蛋白質感染粒子「プリオン」と細胞内小胞輸送,
第8回共同利用・共同研究「酵素学研究拠点」シンポジウム—タンパク質代謝・分解系の酵素学—, Feb. 2015.
6. Keiji Uchiyama, 臼井 健, Masashi Yano and Suehiro Sakaguchi :
プリオン感染はポストゴルジ小胞輸送を抑制する,
第28回中国四国ウイルス研究会, Jun. 2013.
7. Keiji Uchiyama, 臼井 健, Masashi Yano and Suehiro Sakaguchi :
プリオン感染によるポストゴルジ小胞輸送抑制,
第54回日本生化学会 中国・四国支部例会, Jun. 2013.
8. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染は神経細胞におけるインスリンシグナル異常を引き起こす,
第27回中国四国ウイルス研究会抄録集, Jun. 2012.
9. Suehiro Sakaguchi :
プリオン病の基礎研究:プリオン蛋白の病態機序,
第11回徳島神経難病セミナー, Jan. 2012.
10. Keiji Uchiyama and Suehiro Sakaguchi :
プリオン感染細胞における細胞内小胞輸送の抑制,
第26回中国四国ウイルス研究会抄録集, Jun. 2011.
11. Suehiro Sakaguchi, 宮田 博規, Yoshitaka Yamaguti, 村松 直美, Tsuyoshi Mori, Keiji Uchiyama and Sachiko Inubushi :
異なるプリオン株の産生メカニズムについて,
第26回中国四国ウイルス研究会 徳島大学青藍会館 徳島, Jun. 2011.
12. Suehiro Sakaguchi :
Roles of a prion protein family in neurodegeneration,
Enzyme Research Forum 2011 in Nantong University. Nantong University. China., Mar. 2011.
13. Tsuyoshi Mori, 村松 直美, Yoshitaka Yamaguti, Sachiko Inubushi, Masashi Yano, Koji Fujita and Suehiro Sakaguchi :
プリオン蛋白過剰発現により誘導される細胞死の機序,
第26回中国四国ウイルス研究会 岡山大学創立50周年記念館 岡山, Jun. 2010.

Patent:

1. Suehiro Sakaguchi and Junji Chida : 抗プリオン蛋白質抗体とその用途, (Apr. 2015), 2015-077742 (Apr. 2015).

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Elucidation of the pathogenic mechanism and screening of therapeutic compounds in prion disease (Project/Area Number: 19H03548 )
  • Prion protein is a target molecule for a novel anti-influenza therapeutic (Project/Area Number: 17K19661 )
  • プリオン以外のプリオン病の病原体の同定とその病原性メカニズムの解明 (Project/Area Number: 17H05701 )
  • プリオンの増殖と病原性獲得に重要なプリオンの細胞内移動に関与する分子の同定 (Project/Area Number: 15H01560 )
  • Elucidation of our recent findings on the protective role of prion protein against lethal infection with influenza A viruses is useful for development of a new type of anti-influenza drugs (Project/Area Number: 15K15380 )
  • Development of basic technology for therapy of prion diseases based on Sortilin function (Project/Area Number: 26460557 )
  • Elucidation of the vesicular trafficking mechanism for prion propagation on the basis of our previous findings of the disturbed vesicular trafficking in prion disease (Project/Area Number: 26293212 )
  • Identification of a host molecule inportant for prion infection (Project/Area Number: 25670422 )
  • The development of a ultra-sensitive diagnostic technique for BSE(Mad cow disease) (Project/Area Number: 20580354 )
  • Elucidation of a signaling pathway of prion protein in neuronal cells (Project/Area Number: 16590387 )
  • Functional proteomics analysis of non-vesicular release mechanisms in stress exposed neuron-role of stress-induced non-vesicular release Prion, NDI and FGF-1 in neuron (Project/Area Number: 15390028 )
  • プリオン病における神経細胞変性死の分子機構解明 (Project/Area Number: 15016087 )
  • Identification of prion-receptor molecules (Project/Area Number: 14570267 )
  • PrP pre-mRNA 3'プロセッシング異常と神経細胞死の分子機構解明 (Project/Area Number: 14035244 )
  • プリオン病における神経細胞変性死の分子機構解明 (Project/Area Number: 14017076 )
  • プリオン病における神経細胞変性死の分子機構解明 (Project/Area Number: 13210112 )
  • プリオン病における神経細胞変性死の分子機構解明 (Project/Area Number: 12210119 )
  • プリオン蛋白欠損マウスで認められる加齢に伴う神経細胞変性死の分子機構解明 (Project/Area Number: 12050232 )
  • Molecular Mechanisms for Purkinje Cell Degeneration and Demyelination in Prion Protein-Deficient Mice. (Project/Area Number: 11694292 )
  • プリオン蛋白(PrP)結合ペプチドの同定とそのプリオン病治療への応用 (Project/Area Number: 10878140 )
  • MOLECULAR MECHANISMS FOR PRION PROTEIN CONVERSION AND CELL-TYPES INVOLVED IN THE CONVERSION IN VIVO (Project/Area Number: 09470154 )
  • Elucidation of the nature of a Creutfeldt-Jakob disease agent using prion protein gene-knockout mice (Project/Area Number: 09470086 )
  • MECHANISMS OF NEUTONAL CELL DEATH IN PRION PROTEIN-LESS MICE (Project/Area Number: 09044321 )
  • クロイツフェルト・ヤコブ病の病原因子はプリオンでない可能性がある (Project/Area Number: 08877056 )
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