Tokushima University / Educator and Researcher Directory --- Kitaoka, Kazuyoshi

Field of Study

○	Environmental Physiology, 体力医学
○	イノベーション教育，アントレプレナーシップ教育

Subject of Study

○	Retinoic acid signaling and brain function, Feed-forward regulation of carotid blood flow, Biological effects by extremely low-frequency magnetic fields (retinoic acid, vitamin A, sleep, aging, emotion, Carotid blood flow, Feed-forward regulation, Extremely low-frequency magnetic fields)
○	イノベーションワークショップ実施による心理的資本への影響

Book / Paper

Book:

1.	武田浩太郎, 鶴田宏樹, 祇園景子, 石田祐, 三上淳, 松下正和, 大石哲, 大路剛, 友淵貴之, 加藤知愛, 阿部晃成, Junko Kanai, Kazuyoshi Kitaoka and 齊藤誠一 : ソーシャルイノベーションの教科書ー災害に強いレジリエント社会を創るー, 株式会社ミネルバ書房, Mar. 2024.
2.	Kazuyoshi Kitaoka, Sumihare Noji and 田中雅範 : テクノロジーベンチャー経営大全, 現代図書, Kanagawa, Apr. 2023.
3.	Kazuyoshi Kitaoka : Tazukawa bouldering area guide, Mar. 2020.
4.	本田幸夫, 松井謙二, Kazuyoshi Kitaoka, 西應浩司, 北村浩, 横山広充, 古屋誠一, 黒須誠治, 吉長成恭, 八木雅和, 中山学之, 横田幸信, 釜剛史, 森本千佳子, 西之坊穂 and : イノベーションを生み出す共創・共感のデザイン思考, 国立研究開発法人新エネルギー・産業技術総合開発機構, Mar. 2018.
5.	Toshitaka Ikehara, Hiroyoshi Sei, Hiroyuki Tanaka, Takashi Uebanso, Kazuyoshi Kitaoka, Akira Takahashi, Mutsumi Nakahashi, Yutaka Nakaya and Hiroaki Fujihara : 人体生理学の基礎改訂第2版, 医学出版社, Aug. 2016. (Keyword) physiology

Academic Paper (Judged Full Paper):

1.	Kazuyoshi Kitaoka and Tomoko Tamaari : Tokushima University i.school Its Conception, Realization, and Outlook, Journal of University Education Research, Vol.20, 61-65, 2023. (Summary) 徳島大学高等教育研究センター学修支援部門創新教育推進班では，2022年4月より日本のイノベーション教育において先駆的な存在であるi.schoolの教育手法を取り入れた教育プログラム「徳島大学i.school」を，i.schoolの運営団体である一般社団法人日本社会イノベーションセンターの支援と正式な認可のもとで開始した．本報告では，そのねらいと経緯について，イノベーション教育に関する歴史的背景を踏まえて紹介する． (Keyword) innovation education / innovation workshop / design thinking (Tokushima University Institutional Repository) ● Metadata: 118146 (Tokushima University Institutional Repository: 118146)
2.	Kazuyoshi Kitaoka, Shiyori Kawata, Tomohiro Yoshida, Fumiya Kadoriku and Mitsuo Kitamura : Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line, PLoS ONE, Vol.11, No.4, e0154167, 2016. (Summary) Extremely low-frequency magnetic fields (ELF-MFs) are generated by power lines and household electrical devices. In the last several decades, some evidence has shown an association between ELF-MF exposure and depression and/or anxiety in epidemiological and animal studies. The mechanism underlying ELF-MF-induced depression is considered to involve adrenal steroidogenesis, which is triggered by ELF-MF exposure. However, how ELF-MFs stimulate adrenal steroidogenesis is controversial. In the current study, we investigated the effect of ELF-MF exposure on the mouse adrenal cortex-derived Y-1 cell line and the human adrenal cortex-derived H295R cell line to clarify whether the ELF-MF stimulates adrenal steroidogenesis directly. ELF-MF exposure was found to significantly stimulate adrenal steroidogenesis (p < 0.01-0.05) and the expression of adrenal steroid synthetic enzymes (p < 0.05) in Y-1 cells, but the effect was weak in H295R cells. Y-1 cells exposed to an ELF-MF showed significant decreases in phosphodiesterase activity (p < 0.05) and intracellular Ca2+ concentration (p < 0.01) and significant increases in intracellular cyclic adenosine monophosphate (cAMP) concentration (p < 0.001-0.05) and cAMP response element-binding protein phosphorylation (p < 0.05). The increase in cAMP was not inhibited by treatment with NF449, an inhibitor of the Gs alpha subunit of G protein. Our results suggest that ELF-MF exposure stimulates adrenal steroidogenesis via an increase in intracellular cAMP caused by the inhibition of phosphodiesterase activity in Y-1 cells. The same mechanism may trigger the increase in adrenal steroid secretion in mice observed in our previous study. (Tokushima University Institutional Repository) ● Metadata: 112306 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0154167 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27100201 ● Summary page in Scopus @ Elsevier: 2-s2.0-84964653269 (Tokushima University Institutional Repository: 112306, DOI: 10.1371/journal.pone.0154167, PubMed: 27100201, Elsevier: Scopus)
3.	Yuki Hosono, Kazuyoshi Kitaoka, Ryo Urushihara, Hiroyoshi Sei and Yohsuke Kinouchi : Anxiety affects amplitudes of red and green color-elicited flash visual evoked potentials in humans, The Journal of Medical Investigation : JMI, Vol.61, No.1,2, 79-83, 2014. (Summary) It has been reported that negative emotional changes and conditions affect the visual faculties of humans at the neural level. On the other hand, the effects of emotion on color perception in particular, which are based on evoked potentials, are unknown. In the present study, we investigated whether different anxiety levels affect the color information processing for each of 3 wavelengths by using flash visual evoked potentials (FVEPs) and State-Trait Anxiety Inventory. In results, significant positive correlations were observed between FVEP amplitudes and state or trait anxiety scores in the long (sensed as red) and middle (sensed as green) wavelengths. On the other hand, short-wavelength-evoked FVEPs were not correlated with anxiety level. Our results suggest that negative emotional conditions may affect color sense processing in humans. (Keyword) flash visual evoked potentials / light emission diodes / color perception / State-Trait Anxiety Inventory (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.61.79 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24705753 ● CiNii @ National Institute of Informatics (CRID): 1390282679221416448 ● Summary page in Scopus @ Elsevier: 2-s2.0-84897950367 (DOI: 10.2152/jmi.61.79, PubMed: 24705753, CiNii: 1390282679221416448, Elsevier: Scopus)
4.	Motoshi Masuda, Takahiro Emoto, Asato Suzuki, Masatake Akutagawa, Tomoki Kitawaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shigeru Obara, Kazuo Yoshizaki, Shinsuke Konaka and Yohsuke Kinouchi : Evaluation of blood flow velocity waveform in common carotid artery using multi-branched arterial segment model of human arteries, Biomedical Signal Processing and Control, Vol.8, No.6, 509-519, 2013. (Summary) Arteriosclerosis is considered to be a major cause of cardiovascular diseases, which account for approximately 30% of the causes of death in the world. We have recently demonstrated a strong correlation between arteriosclerosis (arterial elasticity) and two characteristics: maximum systolic velocity (S1) and systolic second peak velocity (S2) of the common carotid artery flow velocity waveform (CCFVW). The CCFVW can be measured by using a small portable measuring device. However, there is currently no theoretical evidence supporting the causes of the relation between CCFVW and arterial elasticity, or the origin of the CCFVW characteristics. In this study, the arterial blood flow was simulated using a one-dimensional systemic arterial segments model of human artery in order to conduct a qualitative evaluation of the relationship between arterial elasticity and the characteristics of CCFVW. The simulation was carried out based on the discretized segments with the physical properties of a viscoelastic tube (the cross-sectional area at the proximal and terminal ends, the length, and the compliance per unit area of the tube (CS)). The findings obtained through this study revealed that the simulated CCFVW had shape similar characteristics to that of the measured CCFVW. Moreover, when the compliance CS of the model was decreased, the first peak of the simulated-CCFVW decreased and the second peak increased. Further, by separating the anterograde pulse wave and the reflected pulse wave, which form the CCFVW, we found that the decrease in the first peak of the simulated CCFVW was due to the arrival of a reflected pulse wave from the head after the common carotid artery toward the arrival of a anterograde pulse wave ejected directly from the heart and that the increase in the second peak resulted from the arrival of the peak of the reflected pulse wave from the thoracic aorta. These results establish that the CCFVW characteristics contribute to the assessment of arterial elasticity. (Keyword) Common carotid / Hemodynamics / Fluid simulation / Artery segments model / Artery elasticity (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bspc.2013.05.005 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84878849060 (DOI: 10.1016/j.bspc.2013.05.005, Elsevier: Scopus)
5.	Kazuyoshi Kitaoka, Noriyuki Shimizu, Koji Ono, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazunori Ishimura, Hiroyoshi Sei and Kazuo Yoshizaki : The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice, Neuropharmacology, Vol.72, 58-65, 2013. (Summary) The retinoic acid (RA, a vitamin A metabolite) receptor (RAR) is a transcription factor. Vitamin A/RA administration improves the Alzheimer's disease (AD)- and age-related attenuation of memory/learning in mouse models. Recently, a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) was identified as a key molecule in RA-mediated anti-AD mechanisms. We investigated the effect of chronic administration of the RAR agonist Am80 (tamibarotene) on ADAM10 expression in senescence-accelerated mice (SAMP8). Moreover, we estimated changes in the expression of the amyloid precursor protein (APP), amyloid beta (Aβ), and hairy/enhancer of split (Hes), which are mediated by ADAM10. Spatial working memory and the levels of a hippocampal proliferation marker (Ki67) were also assessed in these mice. ADAM10 mRNA and protein expression was significantly reduced in the hippocampus of 13-month-old SAMP8 mice; their expression improved significantly after Am80 administration. Further, after Am80 administration, the expression levels of Hes5 and Ki67 were restored and the deterioration of working memory was suppressed, whereas APP and Aβ levels remained unchanged. Our results suggest that Am80 administration effectively improves dementia by activating the hippocampal ADAM10-Notch-Hes5 proliferative pathway. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neuropharm.2013.04.009 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23624141 ● Summary page in Scopus @ Elsevier: 2-s2.0-84884865233 (DOI: 10.1016/j.neuropharm.2013.04.009, PubMed: 23624141, Elsevier: Scopus)
6.	Noriyuki Shimizu, Sachiko Chikahisa, Yuina Nishi, Saki Harada, Yohei Iwaki, Hiroaki Fujihara, Kazuyoshi Kitaoka, Tetsuya Shiuchi and Hiroyoshi Sei : Maternal Dietary Restriction Alters Offspring's Sleep Homeostasis., PLoS ONE, Vol.8, No.5, e64263, 2013. (Summary) Nutritional state in the gestation period influences fetal growth and development. We hypothesized that undernutrition during gestation would affect offspring sleep architecture and/or homeostasis. Pregnant female mice were assigned to either control (fed ad libitum; AD) or 50% dietary restriction (DR) groups from gestation day 12 to parturition. After parturition, dams were fed AD chow. After weaning, the pups were also fed AD into adulthood. At adulthood (aged 8-9 weeks), we carried out sleep recordings. Although offspring mice displayed a significantly reduced body weight at birth, their weights recovered three days after birth. Enhancement of electroencephalogram (EEG) slow wave activity (SWA) during non-rapid eye movement (NREM) sleep was observed in the DR mice over a 24-hour period without changing the diurnal pattern or amounts of wake, NREM, or rapid eye movement (REM) sleep. In addition, DR mice also displayed an enhancement of EEG-SWA rebound after a 6-hour sleep deprivation and a higher threshold for waking in the face of external stimuli. DR adult offspring mice exhibited small but significant increases in the expression of hypothalamic peroxisome proliferator-activated receptor (Ppar) and brain-specific carnitine palmitoyltransferase 1 (Cpt1c) mRNA, two genes involved in lipid metabolism. Undernutrition during pregnancy may influence sleep homeostasis, with offspring exhibiting greater sleep pressure. (Keyword) Animals / Body Weight / Caloric Restriction / Carnitine O-Palmitoyltransferase / Diet / Electroencephalography / Female / Gene Expression / Homeostasis / Hypothalamus / Mice / PPAR alpha / Pregnancy / Prenatal Exposure Delayed Effects / Sleep / Sleep, REM / Wakefulness (Tokushima University Institutional Repository) ● Metadata: 106073 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.pone.0064263 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23741310 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878536785 (Tokushima University Institutional Repository: 106073, DOI: 10.1371/journal.pone.0064263, PubMed: 23741310, Elsevier: Scopus)
7.	Kazuyoshi Kitaoka, Mitsuo Kitamura, Shun Aoi, Noriyuki Shimizu and Kazuo Yoshizaki : Chronic exposure to an extremely low-frequency magnetic field induces depression-like behavior and corticosterone secretion without enhancement of the hypothalamicpituitaryadrenal axis in mice, Bioelectromagnetics, Vol.34, No.1, 43-51, 2013. (Summary) An extremely low-frequency magnetic field (ELF-MF) is generated by power lines and household electrical devices. Many studies have suggested an association between chronic ELF-MF exposure and anxiety and/or depression. The mechanism of these effects is assumed to be a stress response induced by ELF-MF exposure. However, this mechanism remains controversial. In the present study, we investigated whether chronic ELF-MF exposure (intensity, 1.5 mT; [corrected] total exposure, 200 h) affected emotional behavior and corticosterone synthesis in mice. ELF-MF-treated mice showed a significant increase in total immobility time in a forced swim test and showed latency to enter the light box in a light-dark transition test, compared with sham-treated (control) mice. Corticosterone secretion was significantly high in the ELF-MF-exposed mice; however, no changes were observed in the amount of the adrenocorticotropic hormone and the expression of genes related to stress response. Quantification of the mRNA levels of adrenal corticosteroid synthesis enzymes revealed a significant reduction in Cyp17a1 mRNA in the ELF-MF-exposed mice. Our findings suggest the possibility that high intensity and chronic exposure to ELF-MF induces an increase in corticosterone secretion, along with depression- and/or anxiety-like behavior, without enhancement of the hypothalamic-pituitary-adrenal axis. (Keyword) Adrenal Glands / Adrenocorticotropic Hormone / Animals / Behavior, Animal / Body Size / Corticosterone / Depression / Electromagnetic Fields / Emotions / Gene Expression Regulation, Enzymologic / Hypothalamo-Hypophyseal System / Male / Mice / Mice, Inbred ICR / Norepinephrine / Time Factors / Tyrosine 3-Monooxygenase (Link to Publication Site) ● Publication site (DOI): 10.1002/bem.21743 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22753092 ● Search Scopus @ Elsevier (PMID): 22753092 ● Search Scopus @ Elsevier (DOI): 10.1002/bem.21743 (DOI: 10.1002/bem.21743, PubMed: 22753092)
8.	Kazuyoshi Kitaoka, Mika Shimizu, Noriyuki Shimizu, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazuo Yoshizaki and Hiroyoshi Sei : Retinoic acid receptor antagonist LE540 attenuates wakefulness via the dopamine D1 receptor in mice, Brain Research, Vol.1423, 10-16, 2011. (Summary) Vitamin A is a common lipophilic vitamin, and its function is mainly mediated by the binding of its metabolite retinoic acid to retinoic acid receptors (RARs) and retinoid X receptors. Recently, it was reported that the expression of the RARb (an RAR subtype) gene determines the contribution of the delta oscillation in the sleep electroencephalogram (EEG) patterns in mice. We also reported that 4-week dietary deficiency of vitamin A (VAD) causes the attenuation of delta power in sleep and spontaneous activity in mice. However, our previous study could not clarify whether the attenuation of delta power by VAD is attributed to the suppression of RARs. To address this problem, we investigated whether the chronic administration of LE540 (30mg/kg/day), an antagonist of RARs, for 1 or 4weeks attenuated EEG delta power during sleep in mice. Consequently, 4-week LE540 administration induced a significant attenuation of wakefulness and delta power in non-rapid eye movement sleep. Western blot analysis revealed a significant decrease in the expression of dopamine D1 receptor (D1DR) in the striatum and tyrosine hydroxylase in the midbrain of mice that were administered LE540 for 4weeks. High-performance liquid chromatography analysis of striatal tissue revealed a significant decrease in the homovanillic acid/dopamine ratio. Meanwhile, dopamine levels did not change in these mice. Our results suggest that the 4-week antagonism of RARs induces the attenuation of delta power. However, the attenuation of delta power may be elicited indirectly by the decrease of wakefulness followed by the hypo-expression of dopamine receptors especially D1DR. (Keyword) 3,4-Dihydroxyphenylacetic Acid / Animals / Corpus Striatum / Delta Rhythm / Dibenzazepines / Dopamine / Electroencephalography / Gene Expression Regulation / Homovanillic Acid / Male / Mice / Mice, Inbred C57BL / Receptors, Dopamine D1 / Receptors, Retinoic Acid / Sleep Stages / Time Factors / Wakefulness (Link to Publication Site) ● Publication site (DOI): 10.1016/j.brainres.2011.09.023 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22000589 ● Search Scopus @ Elsevier (PMID): 22000589 ● Search Scopus @ Elsevier (DOI): 10.1016/j.brainres.2011.09.023 (DOI: 10.1016/j.brainres.2011.09.023, PubMed: 22000589)
9.	Noriyuki Shimizu, Sachiko Chikahisa, Kazuyoshi Kitaoka, Seiji Nishino and Hiroyoshi Sei : Refeeding after a 24-hour fasting deepens NREM sleep in a time-dependent manner., Physiology & Behavior, Vol.104, No.3, 480-487, 2011. (Summary) Sleep/wake cycle is regulated by a variety of neuropeptides in the hypothalamus, a brain region that also regulates energy homeostasis and feeding behavior. Since circadian rhythms are affected by energy metabolism and feeding condition, we investigated whether changes in feeding regimen would influence sleep/wake parameters and body temperature. We monitored sleep and body temperature across three days of baseline (day 1), fasting (day 2), and refeeding (day 3) conditions under ordinary ambient temperature and employed different refeeding schedules. Refeeding at ZT1 following the 24-h fasting enhanced EEG delta power in NREM sleep. However, when the time of refeeding was set at either ZT7 or ZT12, the enhancement of EEG delta power was attenuated. The amount of NREM sleep was not largely affected by a 24-h fasting started at ZT1, although fasting that started at ZT12 changed the temporal distribution of NREM sleep. Hypothalamic nNOS mRNA level was increased both before and after refeeding at ZT1 compared with control condition, while there was no significant change in mice refed at ZT7. Level of NPY mRNA in the arcuate nucleus was increased before the refeeding only at ZT1. These results suggest that refeeding after a 24-h fasting makes NREM sleep deeper in a time-dependent manner. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.physbeh.2011.05.011 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21605579 ● Search Scopus @ Elsevier (PMID): 21605579 ● Search Scopus @ Elsevier (DOI): 10.1016/j.physbeh.2011.05.011 (DOI: 10.1016/j.physbeh.2011.05.011, PubMed: 21605579)
10.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : Feed-forward changes in carotid blood flow velocity during active standing., Neuroscience Letters, Vol.487, No.2, 240-245, 2011. (Summary) Orthostatic changes induce temporary loss of circulatory regulation. Feedback systems react to cardiovascular alterations to compensate for the instability. To clarify the existence of anticipatory cardiovascular regulation during active standing, we continuously recorded blood flow velocity (BFV) in the common carotid artery and cerebral blood volume (CBV) in healthy men. The maximum BFV value decreased significantly before standing in the reaction-time condition. The decrease significantly correlated with the change in systolic blood pressure that accompanies upright standing from a supine position. The anticipatory BFV decrease disappeared during self-paced standing, and all BFV parameters significantly declined after the self-paced standing. The CBV recording showed a significant increase in oxyhemoglobin levels before standing in the reaction-time condition. Our study suggests that some feed-forward cardiovascular regulation triggered by central command could be activated before standing, and it may play a functional role in the maintenance of cerebral perfusion during standing. (Keyword) Adult / Blood Flow Velocity / Blood Pressure / Carotid Artery, Common / Humans / Hypotension, Orthostatic / Male / Middle Aged / Posture / Reaction Time / Young Adult (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neulet.2010.10.030 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20970481 ● Search Scopus @ Elsevier (PMID): 20970481 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neulet.2010.10.030 (DOI: 10.1016/j.neulet.2010.10.030, PubMed: 20970481)
11.	Shinya Ozaki, Kazunori Toida, Motohiko Suzuki, Yoshihisa Nakamura, Nobuaki Ohno, Taku Ohashi, Meiho Nakayama, Yuki Hamajima, Akira Inagaki, Kazuyoshi Kitaoka, Hiroyoshi Sei and Shingo Murakami : Impaired olfactory function in mice with allergic rhinitis., Auris, Nasus, Larynx, Vol.37, No.5, 575-583, 2010. (Summary) OBJECTIVE: It has been reported that olfactory function is impaired in patients with allergic rhinitis. However, the mechanism of olfactory dysfunction in allergic rhinitis remains poorly understood. Because of difficulties in obtaining and analyzing human olfactory mucosa due to both technical and ethical issues, an animal model needs to be established to clarify the mechanism of olfactory dysfunction in allergic rhinitis. The purpose of this study was to study olfactory function and changes in olfactory mucosa using allergic rhinitis mice. METHODS: A model of allergic rhinitis mice with olfactory dysfunction was developed by sensitizing with ovalbumin (OVA), and intranasally challenging with the same allergen. Olfactory function of mice with or without allergic rhinitis was assessed by odor detection ability test with cycloheximide and local field potential (LFP) with 1-octanal. We also evaluated histological changes in the olfactory mucosa of allergic rhinitis mice by both light and electron microscopy. RESULTS: Both of odor detection ability test and LFP showed that olfactory function was impaired in mice with allergic rhinitis, but not in mice without allergic rhinitis. Histopathological findings showed prominent infiltration of eosinophils, plasma cells, neutrophils, mast cells, and macrophages in lamina propria of olfactory mucosa of mice with allergic rhinitis, although infiltration of these cells was not seen in control mice. Allergic rhinitis also increased the number and size of glands in olfactory mucosa, suggesting an elevated amount of mucin in olfactory mucosa. CONCLUSION: This study showed for the first time that mice with allergic rhinitis have impaired olfactory function, increased size and number of olfactory glands, and infiltration of eosinophils, neutrophils, mast cells, plasma cells, and macrophages in the olfactory mucosa. This suggests that allergic reactions are seen in olfactory mucosa of mice with allergic rhinitis, and that greater olfactory gland activity is associated with olfactory dysfunction. Also, this mouse model could provide an expedient system for analyzing mechanisms of olfactory dysfunction. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.anl.2009.12.004 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20346605 ● Search Scopus @ Elsevier (PMID): 20346605 ● Search Scopus @ Elsevier (DOI): 10.1016/j.anl.2009.12.004 (DOI: 10.1016/j.anl.2009.12.004, PubMed: 20346605)
12.	Kazuyoshi Kitaoka, Atsuko Sano, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (Tamibarotene)., Neuroscience, Vol.167, No.3, 573-582, 2010. (Summary) Senescence-accelerated mouse prone/8 (SAMP8) mice are known to exhibit age-related deterioration in sleep-wake architecture compared with senescence-accelerated mouse resistant/1 (SAMR1) mice. We investigated whether treatment with Am80 (Tamibarotene), a retinoic acid receptor agonist, would improve sleep in 9-10-month-old SAMP8 mice. One week of Am80 administration improved the decrease in rapid eye movement (REM) sleep shown by SAMP8 mice. Real-time RT-PCR analysis demonstrated an impairment in the hippocampal retinoid cascade (retinoic acid receptor alpha and transthyretin) in SAMP8 in comparison to SAMR1 mice. Am80 treatment induced an increase in mRNA expression in the vesicular acetylcholine transporter in the brainstem and transthyretin in the hippocampus. Furthermore, decreased cortical acetylcholine content in SAMP8 was improved by Am80 administration. Decreased non-REM sleep and delta oscillation were also observed in SAMP8 mice; however, this was not improved by Am80 administration. These results partially support the hypothesis that the effects of aging on sleep-wake architecture are improved by the activation of retinoic acid receptors. The improvement may be induced by the activation of the cholinergic pathway. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neuroscience.2010.01.059 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20138974 ● Search Scopus @ Elsevier (PMID): 20138974 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neuroscience.2010.01.059 (DOI: 10.1016/j.neuroscience.2010.01.059, PubMed: 20138974)
13.	Sachiko Chikahisa, Nobuhiro Fujiki, Kazuyoshi Kitaoka, Noriyuki Shimizu and Hiroyoshi Sei : Central AMPK contributes to sleep homeostasis in mice, Neuropharmacology, Vol.57, No.4, 369-374, 2009. (Summary) AMP-activated protein kinase (AMPK) is an energy-sensing molecular signal involved in glucose and lipid metabolism. The known interaction of sleep with energy metabolism led us to investigate the role of central AMPK in sleep homeostasis. Sleep deprivation (SD) for 6 h increased p-AMPK protein in the hypothalamus and also increased the mRNA level of Ca(2+)/calmodulin (CaM)-dependent protein kinase kinase beta (CaMKK2), an activator of AMPK, and carnitine palmitoyltransferase 1 (CPT1), a downstream signaling factor of AMPK. Central injection of compound C (CC), an inhibitor of AMPK, suppressed EEG delta power during NREM sleep, while 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMPK, enhanced EEG delta power. The treatment of both CC and AICAR attenuated rebound responses of delta power in NREM sleep after SD. These results indicate that central AMPK is involved in the regulation of sleep depth and sleep homeostasis. (Keyword) AMP-Activated Protein Kinases / Aminoimidazole Carboxamide / Animals / Brain / Calcium-Calmodulin-Dependent Protein Kinase Kinase / Carnitine O-Palmitoyltransferase / Central Nervous System Agents / Delta Rhythm / Enzyme Inhibitors / Homeostasis / Hypothalamus / Male / Mice / Mice, Inbred ICR / Phosphorylation / Pyrazoles / Pyrimidines / RNA, Messenger / Ribonucleotides / Sleep / Sleep Deprivation (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neuropharm.2009.07.015 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19615388 ● Search Scopus @ Elsevier (PMID): 19615388 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neuropharm.2009.07.015 (DOI: 10.1016/j.neuropharm.2009.07.015, PubMed: 19615388)
14.	Kazuyoshi Kitaoka, Kaoru Uchida, Naoko Okamoto, Sachiko Chikahisa, Toshitsugu Miyazaki, Eiji Takeda and Hiroyoshi Sei : Fermented ginseng improves the first-night effect in humans, Sleep, Vol.32, No.3, 413-421, 2009. (Summary) The goal of this study was to clarify whether ginseng fermented by lactic acid bacteria (fermented ginseng, FG), can improve the first-night effect (FNE) in humans. Behavioral tests and quantification of mRNA expression related to GABAergic neurotransmission in brain (glutamic acid decarboxylase 1, gamma-aminobutyrate aminotransferase [Abat], gamma-aminobutyric acid transporter 1 [GAT1], gamma-aminobutyric acid transporter 4, gamma-aminobutyric acid A receptor subunit alpha 1 and gamma-aminobutyric acid A receptor subunit alpha 2) were carried out in FG-treated mice. We also performed double-blind sleep recordings of human subjects given FG or placebo. A university-based sleep laboratory. Sixteen healthy male volunteers (aged 20.69 +/- 0.44 years) were observed in the human study. At the end of administration, 2 consecutive all-night polysomnography recordings were performed. Subjects also completed psychological questionnaires, and urine and saliva samples were taken to analyze stress-sensitive markers. The light-dark transition test demonstrated that FG had some anxiolytic effect in mice, but other anxiety measures were unaffected. The hippocampal mRNA expression showed a decrease of Abat and GAT1 suggesting an increase of GABA. Other regions (amygdala and cerebellum) showed no differences. Furthermore, there was some evidence (using simple pairwise comparisons but not supported in the full ANOVA model) that administration of FG tended to diminish decreases in total sleep time and sleep efficiency (seen as first night effects in the placebo group) without affecting sleep architecture. Our results suggest the administration of FG could improve the FNE in humans. The improvement may be related to an anxiolytic effect of FG which acts via GABAergic modification. (Keyword) sleep (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19294962 ● Search Scopus @ Elsevier (PMID): 19294962 (PubMed: 19294962)
15.	Sachiko Chikahisa, Kumiko Tominaga, Tomoko Kawai, Kazuyoshi Kitaoka, Katsutaka Oishi, Norio Ishida, Kazuhito Rokutan and Hiroyoshi Sei : Bezafibrate, a PPARs agonist, decreases body temperature and enhances EEG delta oscillation during sleep in mice., Endocrinology, Vol.149, No.10, 5262-5271, 2008. (Summary) Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear receptor family. PPARs play a critical role in lipid and glucose metabolism. We examined whether chronic treatment with bezafibrate, a PPAR agonist, would alter sleep and body temperature (BT). Mice fed with a control diet were monitored for BT, electroencephalogram (EEG), and electromyogram for 48 h under light-dark conditions. After obtaining the baseline recording, the mice were provided with bezafibrate-supplemented food for 2 wk, after which the same recordings were performed. Two-week feeding of bezafibrate decreased BT, especially during the latter half of the dark period. BT rhythm and sleep/wake rhythm were phase advanced about 2-3 h by bezafibrate treatment. Bezafibrate treatment also increased the EEG delta-power in nonrapid eye movement sleep compared with the control diet attenuating its daily amplitude. Furthermore, bezafibrate-treated mice showed no rebound of EEG delta-power in nonrapid eye movement sleep after 6 h sleep deprivation, whereas values in control mice largely increased relative to baseline. DNA microarray, and real-time RT-PCR analysis showed that bezafibrate treatment increased levels of Neuropeptide Y mRNA in the hypothalamus at both Zeitgeber time (ZT) 10 and ZT22, and decreased proopiomelanocortin-alpha mRNA in the hypothalamus at ZT10. These findings demonstrate that PPARs participate in the control of both BT and sleep regulation, which accompanied changes in gene expression in the hypothalamus. Activation of PPARs may enhance deep sleep and improve resistance to sleep loss. (Keyword) sleep / PPAR (Link to Publication Site) ● Publication site (DOI): 10.1210/en.2008-0285 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18787029 ● Search Scopus @ Elsevier (PMID): 18787029 ● Search Scopus @ Elsevier (DOI): 10.1210/en.2008-0285 (DOI: 10.1210/en.2008-0285, PubMed: 18787029)
16.	Hiroyoshi Sei, Katsutaka Oishi, Sachiko Chikahisa, Kazuyoshi Kitaoka, Eiji Takeda and Norio Ishida : Diurnal amplitudes of arterial pressure and heart rate are dampened in Clock mutant mice and adrenalectomized mice., Endocrinology, Vol.149, No.7, 3576-3580, 2008. (Summary) Arterial pressure (AP), heart rate (HR), and cardiovascular diseases, including ischemic heart attack and cerebrovascular accident, show diurnal variation. Evidence that circadian-related genes contribute to cardiovascular control has been accumulated. In this study, we measured the AP and HR of Clock mutant mice on the Jcl/ICR background to determine the role of the Clock gene in cardiovascular function. Mice with mutated Clock genes had a dampened diurnal rhythm of AP and HR, compared with wild-type control mice, and this difference disappeared after adrenalectomy. The diurnal acrophase in both mean arterial pressure and HR was delayed significantly in Clock mutant mice, compared with wild-type mice, and this difference remained after adrenalectomy. Clock mutant mice had a lower concentration of plasma aldosterone, compared with wild-type mice. Our data suggest that the adrenal gland is involved in the diurnal amplitude, but not the acrophase, of AP and HR, and that the function of the Clock gene may be related to the nondipping type of AP elevation. (Keyword) Adrenalectomy / Animals / Blood Pressure / Circadian Rhythm / Female / Genotype / Heart Rate / Male / Mice / Mice, Inbred BALB C / Mice, Inbred C57BL / Mice, Inbred ICR / Mice, Mutant Strains / Mutation / Trans-Activators (Link to Publication Site) ● Publication site (DOI): 10.1210/en.2007-1714 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18403480 ● Search Scopus @ Elsevier (PMID): 18403480 ● Search Scopus @ Elsevier (DOI): 10.1210/en.2007-1714 (DOI: 10.1210/en.2007-1714, PubMed: 18403480)
17.	Kazuyoshi Kitaoka, Atsushi Hattori, Sachiko Chikahisa, Ken-ichi Miyamoto, Yutaka Nakaya and Hiroyoshi Sei : Vitamin A deficiency induces a decrease in EEG delta power during sleep in mice, Brain Research, Vol.1150, 121-130, 2007. (Summary) Recent report (Maret, S., Franken, P., Dauvilliers, Y., Ghyselinck, N.B., Chambon, P., Tafti, M., 2005. Retinoic acid signaling affects cortical synchrony during sleep. Science 310, 111-113.) has suggested that vitamin A (retinol and its derivatives) is genetically involved in the electroencephalogram (EEG) delta oscillation during sleep. However, this finding has not yet been confirmed by other studies. In this study, we attempted to record the sleep EEG and behavior, and to quantify striatal monoamines in mice fed a vitamin A-deficient (VAD) diet for 4 weeks, in order to clarify the linkage between the delta oscillation and vitamin A. VAD mice demonstrated a significant decrease in the delta power of the EEG. However, 6-h sleep deprivation caused the recovery of the delta power in VAD mice to a level similar to that of the control. VAD also caused the decrease of spontaneous activity throughout 24-h period. Furthermore, dihydroxyphenylacetic acid, a metabolite of dopamine, was decreased significantly in the striatal tissue of VAD mice. Our present results suggest that the deficiency of vitamin A causes the attenuation of delta power in NREM sleep and spontaneous activity. These attenuations may be related to the alteration of striatal dopaminergic function. (Keyword) 3,4-Dihydroxyphenylacetic Acid / Analysis of Variance / Animals / Behavior, Animal / Body Weight / Corpus Striatum / Delta Rhythm / Dopamine / Exploratory Behavior / Male / Mice / Mice, Inbred C57BL / Motor Activity / Serotonin / Sleep / Sleep Deprivation / Spectrum Analysis / Vitamin A / Vitamin A Deficiency (Link to Publication Site) ● Publication site (DOI): 10.1016/j.brainres.2007.02.077 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17400199 ● Search Scopus @ Elsevier (PMID): 17400199 ● Search Scopus @ Elsevier (DOI): 10.1016/j.brainres.2007.02.077 (DOI: 10.1016/j.brainres.2007.02.077, PubMed: 17400199)
18.	Sachiko Chikahisa, Atsuko Sano, Kazuyoshi Kitaoka, Ken-ichi Miyamoto and Hiroyoshi Sei : Anxiolytic effect of music depends on ovarian steroid in female mice., Behavioural Brain Research, Vol.179, No.1, 50-59, 2007. (Summary) Music is known to be able to elicit emotional changes, including anxiolytic effects. The gonadal steroid hormones estradiol and progesterone have also been reported to play important roles in the modulation of anxiety. In the present study, we examined whether the effect of music on anxiety is related to ovarian steroid in female mice. Behavioral paradigms measuring anxiety were tested in gonadally intact (SHAM) and ovariectomized (OVX) female mice chronically treated with either placebo (OVX/Placebo), 17β-estradiol (OVX/E), or progesterone (OVX/P). In the elevated plus maze, light-dark transition, and marble burying tests, SHAM and OVX/P mice exposed to music showed less anxiety than those exposed to white noise or silence while OVX/placebo mice did not show these effects at all. OVX/E mice showed the anxiolytic effect of music only in the marble burying test. Furthermore, pretreatment with progesterone's metabolite inhibitor completely prevented the anxiolytic effect of music in behavioral tests, while pretreatment with a progesterone receptor blocker did not prevent the anxiolytic effect of music. These results suggest that exposure to music reduces anxiety levels, and ovarian steroids, mainly progesterone, may be involved in the anxiolytic effect of music observed in female mice. (Keyword) Anxiety / Music / 17β-estradio / Progesterone / Female mice (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbr.2007.01.010 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17280725 ● Search Scopus @ Elsevier (PMID): 17280725 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbr.2007.01.010 (DOI: 10.1016/j.bbr.2007.01.010, PubMed: 17280725)
19.	Sachiko Chikahisa, Hiroyoshi Sei, Masaki Morishima, Atsuko Sano, Kazuyoshi Kitaoka, Yutaka Nakaya and Yusuke Morita : Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults., Behavioural Brain Research, Vol.169, No.2, 312-319, 2006. (Summary) Music has been suggested to have a beneficial effect on various types of performance in humans. However, the physiological and molecular mechanism of this effect remains unclear. We examined the effect of music exposure during the perinatal period on learning behavior in adult mice, and measured the levels of brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB), which play critical roles in synaptic plasticity. In addition, we measured the levels of 3-phosphoinositide-dependent protein kinase-1 (PDK1) and mitogen-activated protein kinase (MAPK), downstream targets of two main pathways in BDNF/TrkB signaling. Music-exposed mice completed a maze learning task with fewer errors than the white noise-exposed mice and had lower levels of BDNF and higher levels of TrkB and PDK1 in the cortex. MAPK levels were unchanged. Furthermore, TrkB and PDK1 protein levels in the cortex showed a significant negative correlation with the number of errors on the maze. These results suggest that perinatal exposure of mice to music has an influence on BDNF/TrkB signaling and its intracellular signaling pathway targets, including PDK1, and thus may induce improved learning and memory functions. (Keyword) Learning / Music / BDNF / TrkB / MAPK / PDK1 / Mice (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbr.2006.01.021 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16530277 ● Search Scopus @ Elsevier (PMID): 16530277 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbr.2006.01.021 (DOI: 10.1016/j.bbr.2006.01.021, PubMed: 16530277)
20.	Ryou Urushihara, Nagako Murase, C John Rothwell, Masafumi Harada, Yuki Hosono, Kotaro Asanuma, Hideki Shimazu, Kazumi Nakamura, Sachiko Chikahisa, Kazuyoshi Kitaoka, Hiroyoshi Sei, Yusuke Morita and Ryuji Kaji : Effect of repetitive transcranial magnetic stimulation applied over the premotor cortex on somatosensory-evoked potentials and regional cerebral blood flow., Neuroimage, Vol.31, No.2, 699-709, 2006. (Summary) Somatosensory-evoked potentials (SEPs) are attenuated by movement. This phenomenon of 'gating' reflects sensorimotor integration for motor control. The frontal N30 component after median nerve stimulation was shown to be reduced in amplitude prior to hand movement. To investigate the mechanism of this sensory gating, we recorded median SEPs immediately before and after application of monophasic very low-frequency (0.2 Hz) repetitive transcranial magnetic stimulation (rTMS) of 250 stimuli over motor cortex (MC), premotor cortex (PMC), or supplementary motor area (SMA) in 9 healthy volunteers. The stimulus intensity for MC or PMC was set 85% of the resting motor threshold for the hand muscle, and that for SMA was at the active motor threshold for the leg muscle. SEPs showed significant increases in amplitudes of the frontal N30 component after PMC stimulation, but not after SMA or MC stimulation. Low-frequency (1 Hz) biphasic stimulation over PMC showed no significant N30 changes in 6 out of 9 subjects tested, indicating the effect being specific for 0.2 Hz monophasic stimulation. To examine the functional anatomy of the N30 change, single photon emission computed tomography was performed immediately before and after monophasic 0.2 Hz rTMS over PMC in all the 9 subjects. Regional cerebral blood flow showed significant increases mainly in PMC and prefrontal cortex, indicating the involvement of these cortical areas in sensory input gating for motor control. (Keyword) Adult / Brain / Brain Mapping / Cerebrovascular Circulation / Evoked Potentials, Somatosensory / Functional Laterality / Humans / Male / Motor Cortex / Regional Blood Flow / Transcranial Magnetic Stimulation (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neuroimage.2005.12.027 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16466934 ● Search Scopus @ Elsevier (PMID): 16466934 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neuroimage.2005.12.027 (DOI: 10.1016/j.neuroimage.2005.12.027, PubMed: 16466934)
21.	Kazuyoshi Kitaoka, Risa Ito, Hideo Araki, Hiroyoshi Sei and Yusuke Morita : Effect of mood state on anticipatory postural adjustments., Neuroscience Letters, Vol.370, No.1, 65-68, 2004. (Summary) Static postural control has been demonstrated to link with psychological state. However, the effect of psychological state on dynamic postural control remains unclear. In this study, we examined the effect of mood state on anticipatory postural adjustment (APA), one of the most important functions for dynamic postural control. Fourteen healthy male subjects performed unilateral arm elevation tasks after completing a Profile of Mood States (POMS) questionnaire. Mood state measured by POMS and the latency or amplitude of the APA in the ventral muscles (rectus femoris, tibialis anterior) of the lower limb showed significant negative correlations. The correlation between the mood state and APA amplitude in the soleus was found to be significantly positive. There were significant negative correlations between the mood state and reaction-time. These findings suggest that it is possible that dynamic postural control is affected by mood state. (Keyword) Adaptation, Physiological / Adult / Affect / Electromyography / Humans / Male / Movement / Postural Balance / Posture / Psychomotor Performance / Questionnaires / Reaction Time (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neulet.2004.07.088 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15489019 ● Search Scopus @ Elsevier (PMID): 15489019 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neulet.2004.07.088 (DOI: 10.1016/j.neulet.2004.07.088, PubMed: 15489019)

Review, Commentary:

1.	Fukawasa Hiroshi, Nakagomi Madoka, Yamagata Naoko, Katsuki Hiroshi, Kawahara Kohichi, Kazuyoshi Kitaoka, Miki Takami and Shudo Koichi : Tamibarotene: a candidate retinoid drug for Alzheimer's disease., Biological & Pharmaceutical Bulletin, Vol.35, No.8, 1206-1212, Aug. 2012. (Summary) Tamibarotene (Am80), a synthetic retinoid approved in Japan for treatment of acute promyelocytic leukemia (APL), is a retinoic acid receptor (RAR) agonist with high specificity for RARα and RARβ over RARγ. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. Am80 is considered to be a promising candidate drug for treatment of Alzheimer's disease (AD) because of its transcriptional controls of multiple target genes involved in etiology and pathology of AD. In APP23 AD model mice, administration of Am80 decreased the deposition of insoluble amyloid-β(42). In senescence-accelerated mice (SAMP8), Am80 ameliorated the decrease of cortical acetylcholine, as well as reducing anxiety in behavioral tests and improving the sleep deficit. Am80 also effected a significant improvement of memory in the rat scopolamine-induced memory deficit model. Like other retinoids, Am80 also has an immunomodulatory effect and reduces secretion of proinflammatory cytokines and chemokines by astrocytes and microglia surrounding amyloid-β plaques. In a rat experimental autoimmune encephalomyelitis model, Am80 reduced inflammatory cytokines and showed significant efficacy. Retinoids also promote differentiation of neural stem cells, and Am80 improved the recovery of spinal cord-injured rats. Am80 may also improve vascular factors involved in onset and/or progression of AD. Am80 has been in clinical use for treatment of APL in Japan since 2005, and has been reported to have fewer side effects than other retinoids. We have recently started a clinical study to evaluate the efficacy and safety of Am80 for the treatment of Alzheimer's disease. (Keyword) Alzheimer Disease / Animals / Benzoates / Brain / Humans / Receptors, Retinoic Acid / Tetrahydronaphthalenes / Transcription, Genetic (Link to Publication Site) ● Publication site (DOI): 10.1248/bpb.b12-00314 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22863914 ● Search Scopus @ Elsevier (PMID): 22863914 ● Search Scopus @ Elsevier (DOI): 10.1248/bpb.b12-00314 (DOI: 10.1248/bpb.b12-00314, PubMed: 22863914)
2.	Hiroyoshi Sei, Kazuyoshi Kitaoka and Sachiko Chikahisa : Sleep regulatory mechanisms, Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.70, No.7, 1133-1138, Jul. 2012. (Summary) The fact that resting wakefulness does not satisfy the need for sleep suggests that sleep has a critical role for the brain, probably for its maintenance or repair. Neuronal oxidative stress, neuroinflammation, or energy insufficiency in the brain is now considered to be a trigger or cause for sleep induction. And the timing for sleep is controlled by circadian clock which also exists in the brain. Sleep is occurred in the brain, which is regulated by the brain itself. "Why do we sleep ?" Although everyone wants to know the answer for this issue, scientists should still question that "How do we sleep"? (Keyword) Brain / Circadian Clocks / Circadian Rhythm / Humans / Sleep / Time Factors / Wakefulness (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22844794 ● Summary page in Scopus @ Elsevier: 2-s2.0-84867300427 (PubMed: 22844794, Elsevier: Scopus)

Proceeding of International Conference:

1.	Tomoko Tamaari, Kojiro WATANABE, Yuno Arihiro and Kazuyoshi Kitaoka : A Study on Dialogue Design to make a Dementia-friendly Communities, The 10th International Forum on Advanced Technologies, 18-19, Tokushima, Mar. 2024.
2.	Takayuki Tominaga, Masatake Akutagawa, Takahiro Emoto, Yohsuke Kinouchi, Kazuyoshi Kitaoka and Hiroyuki Tanaka : A search method of optimal probe position during measurement of carotid artery blood flow velocity using the ultrasonic doppler, IEEE-EMBS Conference on Biomedical Engineering and Science (IECBES 2018), 302-307, Kuching, Dec. 2018. (Link to Publication Site) ● Publication site (DOI): 10.1109/IECBES.2018.8626707 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85062785689 (DOI: 10.1109/IECBES.2018.8626707, Elsevier: Scopus)
3.	Noriyuki Shimizu, Sachiko Chikahisa, Yohei Iwaki, Kazuyoshi Kitaoka and Hiroyoshi Sei : Male adult mice with low birth weight show an increased sleep pressure, Sleep 2012: 26th Annual Meeting of the Associated Professional Sleep Societies, Boston, Jun. 2012.
4.	Motoshi Masuda, Masatake Akutagawa, Takahiro Emoto, Tomoki Kitawaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shigeru Obara, Kazuo Yoshizaki, Shinsuke Konaka and Yohsuke Kinouchi : Study on blood flow velocity patterns at carotid using one-dimensional computer simulation of humman arteries, Proceedings of the IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI 2012), 651-654, Shenzhen, Jan. 2012. (Summary) 総頸動脈血流速度波形と動脈弾性の関係について，1次元流体解析モデルを用いて検討している．動脈モデルはヒトの全身の主要な動脈を多枝セグメントモデルとして構築したものを用い，動脈弾性を変化させた時の総頸動脈の血流速度波形を求めた結果，動脈弾性の変化により血流速度波形が変化することを示した．これにより総頸動脈の血流速度波形を調べることにより動脈硬化を評価することができる可能性を示した． (Link to Publication Site) ● Publication site (DOI): 10.1109/BHI.2012.6211667 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84864244682 (DOI: 10.1109/BHI.2012.6211667, Elsevier: Scopus)
5.	Koki Aoyama, Takahiro Emoto, Masatake Akutagawa, Motoshi Masuda, Shota Minato, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : Evaluating the atherosclerosis based on the blood flow velocity waveform of common carotid artery, Proceedings of the IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI 2012), 655-658, Shenzhen, Jan. 2012. (Summary) 頸動脈血流速度波形は動脈硬化等の循環器系の状態を反映していることが知られている．また動脈硬化のスクリーニング指標として，CAVIが実用に供されている．本研究では頸動脈血流波形から自動抽出可能な動脈弾性指標の提案を目的とし，評価の妥当性を確認するため，血流速度と CAVI の測定を行い，提案した指標と CAVI の関係を調べた．また，動脈は加齢により硬化する事や，男性に比べ閉経前の女性は軟らかい事から，提案した指標と年齢の関係や性差について調べた． (Link to Publication Site) ● Publication site (DOI): 10.1109/BHI.2012.6211668 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84864258384 (DOI: 10.1109/BHI.2012.6211668, Elsevier: Scopus)
6.	Hiroyoshi Sei, Kazuyoshi Kitaoka, Nobuhiro Fujiki, Noriyuki Shimizu, Sachiko Chikahisa, Hiroaki Fujihara, Tetsuya Shiuchi and A Nakai : Mice lacking heat shock factor 1 show evening-type sleep/wake rhythm, World sleep 2011, Kyoto, Oct. 2011.
7.	Noriyuki Shimizu, Sachiko Chikahisa, Yohei Iwaki, Kazuyoshi Kitaoka and Hiroyoshi Sei : Low birth weight by undernutrition during pregnancy elicits anxiety and depression in male offspring mice, World sleep 2011, Kyoto, Oct. 2011.
8.	Sachiko Chikahisa, Noriyuki Shimizu, Kazuyoshi Kitaoka, Yohei Iwaki, Hiroaki Fujihara, Tetsuya Shiuchi and Hiroyoshi Sei : Sleep/wake regulation in PPAR knockout mice, World sleep 2011, Oct. 2011.
9.	Noriyuki Shimizu, Sachiko Chikahisa, Kazuyoshi Kitaoka and Hiroyoshi Sei : Sleep regulation in PPARalpha knockout mice, Neuroscience 2010, San Diego, USA, Nov. 2010.
10.	Sachiko Chikahisa, Kazuyoshi Kitaoka, Noriyuki Shimizu and Hiroyoshi Sei : Hypothalamic AMPK contributes to homeostatic sleep regulation, Neuroscience 2010, San Diego, USA, Nov. 2010.
11.	Kazuyoshi Kitaoka, Shimizu Mika, Shimizu Noriyuki, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Retinoic acid receptors antagonist LE540 atenuates EEG delta power during sleep via dopamine D1 receptor in mice, Neuroscience 2010, San Diego, Nov. 2010.
12.	Kazuyoshi Kitaoka, Shimizu Mika, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Four-week administration of retinoic acid receptors antagonist LE540 attenuates EEG delta power during sleep in mice, The 6Th Congress of Asian Sleep Research Society, Oct. 2009.
13.	Sachiko Chikahisa, Noriyuki Shimizu, Kazuyoshi Kitaoka, Nobuhiro Fujiki and Hiroyoshi Sei : Central AMPK contributes to sleep regulation, 36th International Union of Physiological Sciences, Kyoto, Aug. 2009.
14.	Kazuyoshi Kitaoka, Atsuko Sano, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Administration of Am80, an agonist of retinoic acid receptor, improves the aging-related decrease of REM sleep in SAMP8 mice, 36th International Congress of Physiological Sciences, Aug. 2009.
15.	Sachiko Chikahisa, Kazuyoshi Kitaoka and Hiroyoshi Sei : Complex auditory stimuli reduce anxiety level in an ovarian steroid hormone-dependent manner in female mice, Neuroscience 2008, Washington DC, USA, Nov. 2008.
16.	Kazuyoshi Kitaoka : First-night effect is attenuated by chronic administration of pre-fermented ginseng in human, The 21th Century COE Program in the University of Tokushima 3rd International Conference, Tokyo, Dec. 2007. (Keyword) sleep / First-night effect / ginseng / human
17.	Hiroyoshi Sei, Sachiko Chikahisa, Kazuyoshi Kitaoka and Tomoko Kawai : Relationship between spontaneous apnea and surge of arterial pressure during REM sleep in ICR mice, Neuroscience 2007, San Diego, USA, Nov. 2007.
18.	Sachiko Chikahisa, Kazuyoshi Kitaoka, Hiroyoshi Sei, Katsutaka Oishi, Shigenobu Shibata and Norio Ishida : Chronic bezafibrate treatment advances circadian rhythms of sleep and body temperature in mice, 2nd World Congress of Chronobiology, Tokyo, Nov. 2007.
19.	Sachiko Chikahisa, Hiroyoshi Sei, Masaki Morishima, Atsuko Sano, Kazuyoshi Kitaoka, Yutaka Nakaya and Yusuke Morita : Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults, Neuroscience 2006, Atlanta, USA, Oct. 2006.
20.	Kazuyoshi Kitaoka : Deficiency of vitamin A induces the decrease of slow-wave activity in mice., Neuroscience 2006, Atlanta, Oct. 2006.
21.	Sachiko Chikahisa, Hiroyoshi Sei, Atsuko Sano, Kazuyoshi Kitaoka and Yusuke Morita : Anxiolytic effects of music depend on ovarian steroid in female mice, International Behavioral Neuroscience Society, Whistler, Canada, May 2006.

Proceeding of Domestic Conference:

1.	IKUTA Kodai, Masatake Akutagawa, Takahiro Emoto, Yohsuke Kinouchi, Kazuyoshi Kitaoka, Hirotsugu Yamada and Hiroyuki Tanaka : CNNを用いた総頸動脈血流速度分布と動脈硬化症の関連性の検討, Proceedings of The 63rd Annual Conference of Japanese Society for Medical and Biological Engineering, 314, May 2024. (Summary) アテローム性動脈硬化症は循環系疾患の危険因子の 1 つであり，動脈硬化症は肥満・喫煙・運動不足や生活習慣病によって進行する．現在では動脈硬化症の検査方法の一つとして，超音波エコー画像で評価する頸動脈超音波検査がある．しかし，測定・評価にはある程度の専門知識が必要になる．そこで本研究グループでは，容易に測定可能な小型のスクリーニングデバイスとして頸動脈血流速度測定装置の開発に取り組んでいる．総頸動脈における血流速度の時間変化 ( 以後，総頸動脈血流速度波形と記す ) の数値シミュレーションを行った結果，動脈弾性が変化すると総頸動脈血流速度波形には違いが現れることが示されている．しかし，総頸動脈における血流速度分布の時間変化 ( 以後，総頸動脈血流速度分布と記す ) と動脈硬化症の関連性については，まだ十分に明らかになっていない．そこで，頸動脈血流速度測定装置の試作機で測定された健常者と動脈硬化症患者の総頸動脈血流速度分布の比較を行った．測定された血流速度分布を学習データとして畳み込みニューラルネットワークを用い，健常者と動脈硬化症患者に分類した．その結果，総頸動脈血流速度波形の特徴量を用いて分類を行った結果より，正確率は向上した．今後は，両者間の違い・特徴を明らかにしていきたい．
2.	TAKADA Taiyo, Tomoko Tamaari, Tetsuro Katayama, Shizuyo Koide, Junko Kanai and Kazuyoshi Kitaoka : 徳島大学 i.school での学びと成長 - 参加学生の視点より ‐, イノベーション教育学会第11回年次大会, Mar. 2024.
3.	NAKAI Risa, Tomoko Tamaari, Tetsuro Katayama, Shizuyo Koide, Junko Kanai and Kazuyoshi Kitaoka : 失敗感尺度と創造的態度の相関性-2023年度DP生より-, イノベーション教育学会第11回年次大会, Mar. 2024.
4.	Tomoko Tamaari, Tetsuro Katayama, 小出静代, Junko Kanai and Kazuyoshi Kitaoka : 徳島大学 i.school におけるイノベーション教育の試み, 第20回ものづくり・創造性教育に関するシンポジウム講演要旨集, 24-26, Dec. 2023.
5.	SHUTA Akai, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka and Yohsuke Kinouchi : Sound field analysis of split-type ultrasonic probe receiver for blood flow velocity measurement, 2023 Shikoku-Section Joint Convention Record of the Institutes of Electrical and Related Engineers, 199, Sep. 2023.
6.	Tomoko Tamaari, Maria Moriguchi, Yuno Arihiro, Kazuyoshi Kitaoka and Kenji Terada : Supporting of the Relationship Building for Participants in Student's Project During the Coronavirus Pandemic, Research Report of JSET Conferences, Vol.2023, No.1, 63-68, May 2023. (Summary) 徳島大学高等教育研究センター学修支援部門創新教育推進班では，学部学科の分野を横断する自主的なプロジェクト活動を支援している．新型コロナウィルスの世界的流行により，2020年度以降の対面活動が制限された結果，プロジェクト活動に停滞が起こった．停滞した活動を支援するために，可視化や思考支援のワークショップを実施した結果，学生間の関係性が改善する傾向が示された. (Keyword) higher education / workshop / モノづくり / 学生プロジェクト / communication / フューチャーセッション (Link to Publication Site) ● Publication site (DOI): 10.15077/jsetstudy.2023.1_63 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.15077/jsetstudy.2023.1_63 (DOI: 10.15077/jsetstudy.2023.1_63)
7.	Tomoko Tamaari, Tetsuro Katayama, 小出静代, Junko Kanai, 有廣悠乃, Yu Ishihara and Kazuyoshi Kitaoka : 徳島大学i.schoolの取組み- 徳島大学が推進するイノベーション教育の事例紹介 -, 第10回イノベーション教育学会年次大会, Nov. 2022. (Keyword) イノベーション教育
8.	Takanori Fukuhara, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka and Yohsuke Kinouchi : Sound field measurement system of ultrasound probe for the doppler velocimeter, 2022 Shikoku-Section Joint Convention Record of the Institutes of Electrical and Related Engineers, 137, Sep. 2022.
9.	加藤浩介, 島岡未来子, 塚本恵, 鶴田宏樹 and Kazuyoshi Kitaoka : 政策共創セッション「コロナ禍を超えて -イノベーション教育の``これから``を考える-」, イノベーション教育学会第9回年次大会, Feb. 2022.
10.	鶴田宏樹, 三上淳, 加藤知愛, 祗園景子, 石田祐, 友渕貴之, Junko Kanai, Kazuyoshi Kitaoka, 和仁裕之, 森高智弥, 中原康行, 後藤燿 and 武田浩太郎 : 大人数の受講生を対象としたオンラインによるイノベーション教育の設計・実施 ―全国アントレプレナーシップ人材育成プログラム・コース1を事例として―, イノベーション教育学会第9回年次大会, Feb. 2022.
11.	祗園景子, 三上淳, 加藤知愛, 石田祐, 友渕貴之, Junko Kanai, Kazuyoshi Kitaoka, 阿部晃成, 鶴田宏樹 and 武田浩太郎 : レジリエント社会の構築を牽引する起業家精神育成プログラム―2021年度実施報告―, イノベーション教育学会第9回年次大会, Feb. 2022.
12.	Tetsuro Katayama, Junko Kanai, 小出静代, Tomoko Tamaari and Kazuyoshi Kitaoka : 徳島大学の新入生，新任教員に対するオンライン・イノベーション・ワークショップの取り組み, イノベーション教育学会第9回年次大会, Feb. 2022.
13.	Kazuyoshi Kitaoka, Tomoko Tamaari, Tetsuro Katayama, Junko Kanai and 小出静代 : 「未来の本屋」イノベーションワークショップの設計，実施とその分析, イノベーション教育学会第9回年次大会, Feb. 2022.
14.	Takanori Fukuhara, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka and Yohsuke Kinouchi : Evaluation of sound pressure distribution of divided-type ultrasound probe for the doppler velocimeter using computer similations, Shikoku-Section Joint Convention Record of the Institutes of Electrical and Related Engineers, 167, Sep. 2021.
15.	Yuki Matsugi, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Hirotsugu Yamada, 鳥居裕太 and Yohsuke Kinouchi : 収縮期加速時間と動脈硬化症の関連性に関する検討, 第60回日本生体医工学会大会, Jun. 2021.
16.	Masatake Akutagawa, Yuki Terai, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Hirotsugu Yamada, Yuta Torii and Yohsuke Kinouchi : Study on blood flow velocity waveform in common carotid artery in patients with atherosclerosis, 第59回日本生体医工学会学術大会, May 2020.
17.	Kazuyoshi Kitaoka, Ryoko Buma, 石原佑, 橋爪太 and Fumiki Morimatsu : 大学スタートアップスタジオ「U-tera」の設置とその取り組み, 第8回イノベーション教育学会大会, Feb. 2020.
18.	Tomoko Tamaari, Kazuyoshi Kitaoka and 小野恵里 : グラフィックファシリテーションによる対話の促進の可能性, 令和元年度全学FD推進プログラム大学教育カンファレンスin徳島発表抄録集, 12-13, Dec. 2019. (Keyword) グラフィックファシリテーション
19.	森口茉梨亜, Kenji Terada, Kazuya Kusaka, Hiroyuki Ukida, Junko Kanai, and Kazuyoshi Kitaoka : 徳島大学イノベーションプラザにおける学生プロジェクトの活動∼教学IRによる教育の質保証を目指して∼, 大学教育カンファレンス in 徳島, Dec. 2019.
20.	Kazuyoshi Kitaoka, Tomoko Tamaari, 宮越浩子 and 堀井秀之 : オンライン電子ふせんツール「APISNOTE(エイピスノート)」を活用したワークショップの体験, 大学教育カンファレンス2019, Dec. 2019.
21.	Kazuyoshi Kitaoka : 徳島大学における「イノベーション教育のこれまで，そしてこれから」, イノベーション教育学会第7回年次大会, Nov. 2019.
22.	HSU SUNG CHUN, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka and Yohsuke Kinouchi : 頸動脈超音波ドプラ法の最大血流速度抽出法の耐雑音性向上に関する研究, 生体医工学シンポジウム2019 (徳島), Sep. 2019.
23.	, Junko Kanai, Kazuyoshi Kitaoka and Kenji Terada : デザイン思考の教育効果と企業ニーズの比較, 大学教育カンファレンス in 徳島, Dec. 2018.
24.	Kazuyoshi Kitaoka, Hiroshi Yoshida, 伊藤健太, Junko Kanai, , Kenji Terada and Yoshihisa Takaishi : 学生の社会実装を支援する助成金「仁生イノベーショングラント」の実施，課題とその改善, イノベーション教育学会第6回年次大会, Dec. 2018.
25.	, Junko Kanai, Kazuyoshi Kitaoka and Kenji Terada : 理工系大学院生対象のデザイン思考教育の試み, 日本教育工学会第34回全国大会(東北大学河内キャンパス), Sep. 2018.
26.	HSU SUNG CHUN, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Yohsuke Kinouchi and Shinsuke Konaka : Automatic extraction of blood flow velocity waveform feature points and evaluation of arterial elasticity index by systolic area, 2018 Shikoku-Section Joint Convention Record of the Institutes of Electrical and Related Engineers (EHIME), 178, Sep. 2018. (Summary) 本研究グループで開発した超音波ドプラ法を用いた血流速度測定装置を用いて頸動脈血流速度波形の特徴点の自動抽出を試みた．頸動脈血流波形は年齢とともに変化することが知られており，波形は様々な要因により変化していると思われるが，動脈の柔らかさの影響を受けることがわかっている．このため動脈硬化の診断支援への応用が考えられる．血流速度波形の解析には波形のピークやノッチを自動抽出する手法が必要となる．そこでこれまで提案されていた手法を改良し，手動での特徴点抽出と精度を比較したところ，抽出精度は72%程度であった．
27.	Yuki Terai, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Yohsuke Kinouchi and Shinsuke Konaka : Comparison of carotid artery blood flow velocity waveforms due to difference in measuring apparatus, 2018 Shikoku-Section Joint Convention Record of the Institutes of Electrical and Related Engineers (EHIME), 177, Sep. 2018. (Summary) 本研究グループで開発したドプラ効果を用いた血流速度測定装置と超音波画像診断装置を用いて頸動脈血流速度を速度を測定した際の差異について検討した．血流速度測定装置は連続ドプラ法，超音波画像診断装置はパルスドプラ法を用いており，測定部位，測定範囲の違いによる影響があると思われたが，両者の波形を14名の被験者に対して相関係数を用いて比較したが，両波形の形状の類似性は高く波形の比較は可能であると思われた．
28.	Kazuyoshi Kitaoka, Junko Kanai, Kazuya Kusaka, Satoshi Orita, Kenji Terada and Shoichiro Fujisawa : イノベーション教育のための全学組織「創新教育センター」の設置と今後の展望, イノベーション教育学会第5回年次大会, Nov. 2017.
29.	Takayuki Tominaga, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Yohsuke Kinouchi and Shinsuke Konaka : A search method of optimal probe position during measurement of the carotid arterial blood flow velocity using the ultrasonic doppler, 2017 Shikoku-Section Joint Convention Record of the Institutes of Electrical and Related Engineers (EHIME), 162, Sep. 2017.
30.	Junko Kanai, Emi Morimoto, Takafumi Inoue, Chizuru Sasaki, Kazuyoshi Kitaoka, Kazuya Kusaka, Hiroyuki Ukida, Toshihiro Okamoto, Yutaka Kishimoto, Yoshihiro Deguchi, Tomohiro Kubo, Mikito Yasuzawa, Kenji Terada and Shoichiro Fujisawa : 学生の自己能力評価アンケート調査からみたイノベーション教育の課題, 大学教育カンファレンスin徳島, Dec. 2016.
31.	Kazuyoshi Kitaoka : 「ピタゴラ装置」の作成によるデザイン思考の体験, 平成28年度大学教育カンファレンス in 徳島, Dec. 2016.
32.	Kazuyoshi Kitaoka : 徳島大学におけるイノベーション教育ワークショッププログラム「徳島大学イノベーションチャレンジ」の企画・運営, イノベーション教育学会第4回年次大会, Jun. 2016. (Summary) 徳島大学におけるイノベーション教育の先駆けとして，平成27年度において学生主体のワークショップにより新規アイデアを創出し，その実現化を目指すワークショッププログラム「徳島大学イノベーションチャレンジ」を企画し，平成27年10月22日から2月18日の約4か月間試行的に実施した．そのワークショップの概要および経過について報告する．
33.	Kazuyoshi Kitaoka and Kenichi Yoneda : 誘発電位を用いた運動・感覚パフォーマンスを向上させる機能的照明環境の探索ー予備実験の結果よりー, 第74回日本体力医学会中国・四国地方会, Nov. 2015.
34.	Kazuyoshi Kitaoka and Shiyori Kawata : 超低周波変動磁界曝露はマウス副腎由来Y-1細胞のホスホジエステラーゼ活性を抑制させる, 第30回日本生体磁気学会大会, Jun. 2015.
35.	Kazuyoshi Kitaoka and Shiyori Kawata : The mechanism of intracellular cAMP concentration increase induced by extremely low-frequency magnetic field exposure, The 92st Annual Meeting of the Physiological Society of Japan, Mar. 2015.
36.	多田亜梨沙, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Akihiro Inagaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : 超音波ドプラ法を用いた血流速度測定装置のディジタル化に関する検討, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, No.14-13, 241, Sep. 2014. (Summary) 頸動脈血流速度波形を測定することによって動脈硬化の程度など循環器系の様々な状態を知ることができることがわかってきた．小型血流速度測定装置が普及すると日常的に循環器の状態を測定することができるようになり，健康長寿社会へも繋げることもできるかもしれない．そのためには低雑音で扱いの容易な測定装置の開発が必須である．本研究ではFPGAなどのディジタル回路を用いて回路の主要部分再設計し，低雑音の測定装置の開発を試みた．
37.	Kazuyoshi Kitaoka : 血中乳酸測定を用いたスポーツクライミング競技における上肢筋持久力の客観的評価法, 第22回日本運動生理学会大会, Jul. 2014.
38.	Kazuyoshi Kitaoka, Mitsuo Kitamura, 吉田朋広, 角陸文哉 and 川田知代 : 極低周波変動磁界の曝露はcAMP濃度の上昇を介して副腎皮質由来細胞株のステロイド分泌量を亢進させる, 第29回日本生体磁気学会大会, May 2014.
39.	Shiyori Kawata, FUmiya Kadoriku, Mitsuo Kitamura and Kazuyoshi Kitaoka : Exploration of the mechanism for extremely low-frequency magnetic field-indu ced adrenal steroids up-regulation in Y-1 cell, The 91st Annual Meeting of the Physiological Society of Japan, Mar. 2014.
40.	Fumiya Kadoriku, Shiyori Kawata, Mitsuo Kitamura and Kazuyoshi Kitaoka : Chronic exposure of extremely low-frequency magnetic field stimulates aldost erone secretion in H295R cell, The 91st Annual Meeting of the Physiological Society of Japan, Mar. 2014.
41.	清水紀之, Sachiko Chikahisa, Tetsuya Shiuchi, Kazuyoshi Kitaoka and Hiroyoshi Sei : 妊娠期母親マウスの摂餌制限が仔マウスの睡眠調節機構に与える影響, 第65回日本生理学会中国四国地方会, Nov. 2013.
42.	Kazuyoshi Kitaoka : 頸動脈ドップラー血流速度波形解析による非侵襲的動脈硬化度判定法の開発, 平成25年度課題解決型医療機器等開発事業医工連携推進支援事業医工連携推進シンポジウム, Oct. 2013.
43.	Takahiro Hirano, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuyoshi Kitaoka, Yohsuke Kinouchi, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : Study on sound pressure distribution of blood flow velocity in carotid artery, 2013 Shikoku-section Joint Convention Record of the Institutes of Electrical and Related Engineers, 243, Sep. 2013. (Summary) 頸動脈の血流速度波形は動脈硬化など循環器系の状態を表していることがわかっている．従来，血流速度の評価に用いているのは動脈内の最大血流速度を反映していると考えられる時間波形であるが，動脈内の速度分布は時々刻々変化しているにもかかわらず，評価には反映されていない．そこで超音波ドプラ法を用いた頸動脈測定時に測定結果に血流速度分布がどのように影響するかについて，計算機シミュレーションを用いて検討している．
44.	Tomohiro Yoshida, Shun Aoi, Kazuyoshi Kitaoka, Mitsuo Kitamura, Noriyuki Shimizu and Kazuo Yoshizaki : Chronic exposure to extremely low-frequency magnetic field stimulates corticosteroid secretion in both mice and Y-1 cell line, The 90th annual meeting of Physiological Society of Japan, Mar. 2013.
45.	Kazuyoshi Kitaoka, Mitsuo Kitamura, Shun Aoi, Tomohiro Yoshida, Noriyuki Shimizu and Kazuo Yoshizaki : 極低周波変動磁界慢性暴露による副腎皮質ホルモンの分泌増強作用, 第64回日本生理学会中国四国地方会, Oct. 2012.
46.	Motoshi Masuda, Masatake Akutagawa, Tomoki Kitawaki, Shigeru Obara, Hiroyuki Tanaka, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Takahiro Emoto, Shinsuke Konaka and Yohsuke Kinouchi : Evaluation of blood flow velocity patterns in common carotid artery using multi-branched arterial segment model of human arteries, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 257, Sep. 2012. (Summary) 総頸動脈血流速度波形と動脈弾性の関係について，1次元流体解析モデルを用いて検討している．動脈モデルはヒトの全身の主要な動脈を多枝セグメントモデルとして構築したものを用い，動脈弾性を変化させた時の総頸動脈の血流速度波形を求めた結果，動脈弾性の変化により血流速度波形が変化することを示した．これにより総頸動脈の血流速度波形を調べることにより動脈硬化を評価することができる可能性を示した．
47.	Takahiro Hirano, Motoshi Masuda, Shota Minato, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : Relationship of artery elesticity index and gender difference using carotid blood flow velocity waveforms, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 256, Sep. 2012. (Summary) 波形から自動抽出可能な動脈弾性指標の提案を目的とし，評価の妥当性を確認するため，血流速度と CAVI の測定を行い，提案した指標と CAVI の関係を調べた．また，動脈は加齢により硬化する事や，男性に比べ閉経前の女性は軟らかい事から，提案した指標と年齢の関係や性差について調べた．
48.	Shota Minato, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Hiroyuki Tanaka, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Shinsuke Konaka and Yohsuke Kinouchi : Study on automatic threshold selection of blood flow velocity extraction in carotid artery, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 255, Sep. 2012. (Summary) 頸動脈血流速度波形は動脈硬化等の循環器系の状態を反映しており，容易に測定し被測定者に提示することができれば，循環器系疾患の予防・早期発見に繋がる可能性がある．このため，小型頸動脈血流速度の測定装置を開発してきた．従来は測定者が血流速度波形抽出の為に手動でドプラ信号スペクトルの閾値を決定しなければならず，より客観的かつ，自動的な血流速度波形の抽出法の開発が望まれていた．そこで，閾値の自動選択手法について提案し，検討を行った．
49.	Kazuyoshi Kitaoka, Mitsuo Kitamura and Kazuo Yoshizaki : スポーツクライマーおよび一般成人における両腕懸垂時の血中乳酸濃度, 第67回日本体力医学会大会, Sep. 2012.
50.	Shota Minato, Motoshi Masuda, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : 頚動脈血流速度波形抽出の自動化に関する研究, 平成24年電気学会電子・情報・システム部門大会, 1104-1108, Sep. 2012. (Summary) 頸動脈血流速度波形は動脈硬化等の循環器系の状態を反映しており，容易に測定し被測定者に提示することができれば，循環器系疾患の予防・早期発見に繋がる可能性がある．このため，小型頸動脈血流速度の測定装置を開発してきた．従来は測定者が血流速度波形抽出の為に手動でドプラ信号スペクトルの閾値を決定しなければならず，より客観的かつ，自動的な血流速度波形の抽出法の開発が望まれていた．そこで，閾値の自動選択手法について提案し，検討を行った．
51.	Shun Aoi, Kazuyoshi Kitaoka, Mitsuo Kitamura, Noriyuki Shimizu and Kazuo Yoshizaki : 極低周波変動磁界の慢性暴露はマウスにおいて副腎皮質ホルモン分泌を増強させる, 第27回日本生体磁気学会大会, May 2012.
52.	Kazuyoshi Kitaoka, Mitsuo Kitamura and Kazuo Yoshizaki : スポーツクライマーおよび一般成人における両腕懸垂時の乳酸閾値, 第69回日本体力医学会中国・四国地方会, May 2012.
53.	Kazuyoshi Kitaoka, Shimizu Noriyuki, Sachiko Chikahisa, Nakagomi Madoka, Shudo Koichi, Hiroyoshi Sei and Kazuo Yoshizaki : Chronic administration of retinoic acid receptor agonist Am80 induces the ADAM10 expression in the hippocampus of SAMP8 mice, The 89th Annual Meeting of the Physiological Society of Japan, Mar. 2012.
54.	Motoshi Masuda, Masatake Akutagawa, Shigeru Obara, Hiroyuki Tanaka, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Takahiro Emoto, Shinsuke Konaka and Yohsuke Kinouchi : Study on blood flow velocity patterns using one-dimensional computer simulation of human arteries, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 232, Sep. 2011. (Summary) 血流速度測定システムを開発し，様々な条件で総頸動脈(CCA)血流速度測定を行ってきた．先行研究では，測定結果の波形に見られる特徴点の値から，動脈硬化などの評価の検討を行ってきたが，波形の個人差の成因について理論的に裏付けられていない．本研究では数値流体シミュレーションを用いてCCAの血流速度波形の再現を検討した．
55.	Kouki Aoyama, Motoshi Masuda, Shota Minato, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : Evaluation of atherosclerosis using carotid blood flow velocity waveforms, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 231, Sep. 2011. (Summary) 左総頸動脈における頸動脈血流速度波形は加齢の影響を強く受け，収縮期の最大速度に続いて現れる第2のピーク(S2)は動脈の硬化に伴って隆起する事が示唆されている．だが，被験者によってはS2が不明瞭であり，目視による値のばらつきも大きい．本稿では左総頸動脈血流速度波形からS2に替わり定量的・機械的に求めることができる動脈硬化の指標を提案する．そしてその指標の妥当性を確認するために，心臓足首血管指数との関連を調べた．
56.	Shota Minato, Masatake Akutagawa, Shigeru Inui, Yasushi Toyosu, Shigeru Obara, Kazuo Yoshizaki, Hiroyuki Tanaka, Kazuyoshi Kitaoka, Zhong Wang, Shinsuke Konaka, Takahiro Emoto and Yohsuke Kinouchi : Simultaneous Measurement of High Precision Body Surface Electrocardiogram and Blood Flow Velocity, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 230, Sep. 2011. (Summary) 循環器系疾患の予防・早期発見のため，先行研究で小型の血流計測装置を開発し血流動態の解明を目指してきた．さらに詳細な診断ができるように左総頸動脈の血流速度と高精度体表面心電計による心電図との同期測定を行った．
57.	Kazuyoshi Kitaoka, Hajime Miura and Kazuo Yoshizaki : 起立動作に先行する頸動脈血流速度の変動, 第19回日本運動生理学会大会, Aug. 2011.
58.	Kazuyoshi Kitaoka : Chronic exposure of extremly low-frequency magnetic field induces depression-like behavior via up-regulation of corticosterone in mice, 第88回日本生理学会大会, Mar. 2011.
59.	Asato Suzuki, Masahiro Minato, Masatake Akutagawa, Kazuo Yoshizaki, Shigeru Obara, Hiroyuki Tanaka, Yuji Hirao, Takahiro Emoto, Kazuyoshi Kitaoka, Tomoki Kitawaki, Hisao Oka and Yohsuke Kinouchi : Study on blood flow velocity patterns using one-dimensional computer simulation of human arteries, IEICE Technical Report, Vol.110, No.460, 107-111, Mar. 2011. (Summary) 数値流体シミュレーションを用いて総頸動脈血流パターンを再現し，収縮期の最大速度に続いて現れる第2のピーク(S2)が現れる現象の発生要因の特定を目指す. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572357929235968 (CiNii: 1520572357929235968)
60.	Kazuyoshi Kitaoka, Takeshi Onishi, 清水紀之, Sachiko Chikahisa, 小川眞太朗, Kazuo Yoshizaki and Hiroyoshi Sei : HSF1はマウスの睡眠調節に関与する, 第5回臨床ストレス応答学会大会, Nov. 2010.
61.	Koki Aoyama, Shigeru Obara, Hiroyuki Tanaka, Kazuyoshi Kitaoka, Yuji Hirao, Masatake Akutagawa, Takahiro Emoto, Akihiro Inagaki, Shinsuke Konaka, Kazuo Yoshizaki and Yohsuke Kinouchi : 頚動脈血流速度パターンの折れ線近似を用いた評価, 第33回日本生体医工学会中国四国支部大会, 22, Sep. 2010.
62.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : Anticipatory changes in carotid blood flow velocity and cerebral blood flow preceds standing movement., 第87回日本生理学会大会, May 2010.
63.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : Anticipatory changes in carotid blood flow velocity and cerebral blood flow precede standing movement, The Journal of Physiological Sciences, Vol.60, No.Supplement 1, S92, 2010.
64.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Akihiro Inagaki, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : 起立動作時における予測的な脳血流量，総頸動脈血流速度の変化, Journal of Physiological Society of Japan, Vol.72, No.4, 126-127, 2010.
65.	Kazuyoshi Kitaoka : 起立動作時における予測的な脳血流量，総頸動脈血流速度の変化, 第61回日本生理学会中国四国地方会, Nov. 2009.
66.	Kazuyoshi Kitaoka : 起立動作に先行する頸動脈血流速度の変化, 第63回日本体力医学会中国・四国地方会, Jun. 2009.
67.	Kazuyoshi Kitaoka : 起立動作時における予測的血流変動の検討, 第60回日本生理学会中国四国地方会, Nov. 2008.
68.	Kazuyoshi Kitaoka : RARアンタゴニストLE540投与による睡眠への影響, 日本睡眠学会第33回定期学術集会, Jun. 2008.
69.	Kazuyoshi Kitaoka : Sleep architecture and homeostasis in senescence-accelerated prone (SAMP8) mice., 第85回日本生理学会大会, Mar. 2008. (Keyword) sleep / aging
70.	Kazuyoshi Kitaoka : 発酵オタネニンジンの経口摂取はヒト睡眠におけるFirst-night effectを軽減させる, 日本睡眠学会第32回定期学術集会, Nov. 2007. (Keyword) sleep / 第一夜効果 / オタネニンジン
71.	Kazuyoshi Kitaoka : Vitamin A欠損はマウスにおいて自発行動量を減少させ睡眠時デルタ波を減弱させる, 題17回日本病態生理学会大会, Jan. 2007.

Products:

1.	池田晃輝, 木口碧, 住田泰章, 高島健佑, 平井悠貴, , Junko Kanai, Kazuyoshi Kitaoka and Kenji Terada : ヤンマー連携技術経営特論「スピカちゃん」, 徳島ビジネスチャレンジメッセ, Oct. 2018.
2.	吉田俊太郎, 野内彩可, 片倉悠暉, 松本拓真, 大黒嵩浩, , Junko Kanai, Kazuyoshi Kitaoka and Kenji Terada : ヤンマー連携技術経営特論「Raku Raku Mover」, 徳島ビジネスチャレンジメッセ, Oct. 2018.
3.	鵜飼大将, 田中智也, 上本勇希, 宮本上聖, 程宝龍, , Junko Kanai, Kazuyoshi Kitaoka and Kenji Terada : ヤンマー連携技術経営特論「人体強化型ソリューション」, 徳島ビジネスチャレンジメッセ, Oct. 2018.
4.	大西哲平, 片山貴裕, 大下悠, 山本さくら, 泰地宏明, 小林佑莉亜, 細川丈留, , Kazuyoshi Kitaoka, Junko Kanai and Kenji Terada : YKK連携イノベーションチャレンジクラブ「Co Ombus」, 徳島ビジネスチャレンジメッセ, Oct. 2018.
5.	菊池和貴, 福本和生, 朝枝貴弘, 細井龍太郎, 政岡翔, , Kazuyoshi Kitaoka, Junko Kanai and Kenji Terada : パナソニックサイクルテック連携イノベーションチャレンジクラブ「爽快お遍路」, 徳島ビジネスチャレンジメッセ, Oct. 2018.
6.	南川幸太郎, 石村太一, 高倉悠, 並河沙弥香, , Kazuyoshi Kitaoka, Junko Kanai and Kenji Terada : ヤンマー連携イノベーションチャレンジクラブ「バイバードネット」, 徳島ビジネスチャレンジメッセ, Oct. 2018.
7.	多田侑生, 小柳功王, 渡辺涼太郎, 沖若奈, , Kazuyoshi Kitaoka, Junko Kanai and Kenji Terada : ヤンマー連携イノベーションチャレンジクラブ「ジバード」, 徳島ビジネスチャレンジメッセ, Oct. 2018.
8.	加藤歩, 新木晶士, 立井裕也, 西川巧真, 礎有希, , Kazuyoshi Kitaoka, Junko Kanai and Kenji Terada : ジェイテクト連携イノベーションチャレンジクラブ「ワクワクガチャガチャ」, 徳島ビジネスチャレンジメッセ, Oct. 2018.
9.	毛笠龍之介, 郭澤華, 小幡翼, 藤川達也, 前田晏里, , Kazuyoshi Kitaoka, Junko Kanai and Kenji Terada : ジェイテクト連携イノベーションチャレンジクラブ「来るくるさる」, 徳島ビジネスチャレンジメッセ, Oct. 2018.
10.	大西哲平, 片山貴裕, 大下悠, 山本さくら, 泰地宏明, 細川丈留, , Kazuyoshi Kitaoka, Junko Kanai and Kenji Terada : 自走式ファスナーの可能性を広げる「Co Ombus」, YKK FASTENING CREATION for 2019, Sep. 2018.

Et cetera, Workshop:

1.	IKUTA Kodai, Masatake Akutagawa, Takahiro Emoto, Yohsuke Kinouchi, Kazuyoshi Kitaoka, Hirotsugu Yamada and Hiroyuki Tanaka : Analysis of common carotid artery blood flow velocity spectrogram using CNN for diagnosis of arteriosclerosis, IEICE Technical Report (MBE), Vol.124, No.137, 1-5, Jul. 2024. (Summary) This research group is developing a carotid artery blood flow velocity measurement device as a simple screening device to investigate hemodynamics of the circulatory system. In this study, with the goal of evaluating and judging the degree of progression of atherosclerosis, we used the common carotid artery blood flow velocity spectrograms of healthy subjects and atherosclerosis patients measured with a prototype carotid artery blood flow velocity measurement device as training data and classified them into healthy subjects and atherosclerosis patients using CNN. The differences between the spectrograms of atherosclerosis patients and healthy subjects were extracted and compared using Glad-CAM. As a result, there were differences in important aspects of the classification between atherosclerosis patients and healthy subjects.
2.	Yuki Matsugi, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Hirotsugu Yamada and Yohsuke Kinouchi : Study on the relationship between features of carotid artery blood flow velocity waveforms and arteriosclerosis using autoencoder, IEICE Technical Report (MBE), Vol.122, No.424, 33-37, Mar. 2023. (Summary) Previous research has revealed that differences in blood flow velocity waveforms appear due to exercise effects and aging, but the relationship between arteriosclerosis and blood flow velocity waveforms (BFVW) has not been fully elucidated. In this study, we used an autoencoder to compare the BFVW of the common carotid artery in arteriosclerosis patients and healthy subjects for the purpose of evaluating the progression of arteriosclerosis. This result suggests that the feature values obtained by the autoencoder may serve as indicators for evaluating the progression of arteriosclerosis. (Keyword) blood flow velocity / carotid artery / atherosclerosis / autoencoder
3.	HSU SUNG CHUN, Masatake Akutagawa, Takahiro Emoto, Kazuyoshi Kitaoka, Hiroyuki Tanaka and Yohsuke Kinouchi : Improvement of noise resistance of blood flow velocity measurement using ultrasonic Doppler method, IEICE Technical Report (MBE), Vol.119, No.137, 7-11, Jul. 2019. (Keyword) ultrasound / Doppler / atherosclerosis / circulatory disease / blood flow velocity
4.	Shoichiro Fujisawa, Kazuya Kusaka, Kazuyoshi Kitaoka, Satoshi Orita, Junko Kanai and Kenji Terada : Outline of "Education Center for Innovation" for nurturing innovation human resources active in the world, The Papers of Technical Meeting on "Control", IEE Japan, Vol.CT-18, No.076, 27-30, Mar. 2018. (Summary) In modern society where globalization rapidly progresses, universities are required to develop human resources capable of responding to such changes. In order to solve it, it is urgently necessary to develop human resources capable of creating innovation, establish "Education Center for Innovation" that intensifies and redistributes campus resources related to innovation education with the aim of fostering human resources capable of creating innovation, building a university innovation education system, and strengthening the creation of innovation human resources . (Keyword) Innovative education / Design thinking / social implementation
5.	Kazuyoshi Kitaoka : レゴブロックを用いたイノベーションとシステム思考の入門, 平成29年度大学教育カンファレンスin徳島, Jan. 2018.
6.	Arisa Tada, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Yohsuke Kinouchi and Shinsuke Konaka : Comparison of the arterial elasticity evaluation based on the carotid blood flow velocity and CAVI, IEICE Technical Report (MBE), Vol.115, No.147, 19-22, Jul. 2015. (Summary) 近年，日本国内における死亡原因の約25%は脳梗塞や心筋梗塞など循環器系疾患であることが厚生労働省より報告されている．家庭における動脈弾性の定期的な診断が実現すれば，生活習慣の改善につながり，動脈硬化の進行を抑制が期待できる．頸動脈血流速度波形では，動脈弾性の指標となりうることが期待されている．そこで，動脈硬化の指標であるCAVIと比較することにより，頸動脈血流速度波形を用いた指標の妥当性を調査した．被験者は弾性134名，女性116名の計250名で，血流速度測定した後，CAVIを測定した．結果，S1やS2/S1，FAIとCAVIに相関があり(r>0.58)，動脈弾性の指標となることを示唆した． (Keyword) blood flow velocity / carotid artery / artery elasticity / CAVI (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520853833178490752 (CiNii: 1520853833178490752)
7.	Kazuyoshi Kitaoka, Shun Aoi, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : 起立に先行する頸動脈血流の変化と血圧との関連, 第63回生理学会中国四国地方会, Oct. 2011.
8.	Kouki Aoyama, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : Evaluation of atherosclerosis using carotid blood flow velocity waveforms, --- Feature extraction of systolic ---, 電子情報通信学会技術研究報告，MEとバイオサイバネティックス研究会, Vol.111, No.121, 41-46, Jul. 2011. (Summary) 左総頸動脈血流速度波形にて，収縮期の最大速度(S1)に続いて現れる第2のピーク(S2)は，動脈硬化の指標となり得ることが示唆されている．だが被験者によってはS2が不明瞭であり，目視による値のばらつきが大きい．そこで，S2に替わり血液速度波形から機械的に求めることができる指標A<sub>HR</sub>， A<sub>SII</sub> (S1以降収縮期面積)を提案する．そして血庄と脈波伝播速度から求められる動脈硬化の指標のCAVI (心臓足首血管指数)との関連からパラメータの妥当性を確認した．その結果A<sub>HR</sub>がCAVIと最も強い相関(r=0.765)があり，動脈硬化の指標として妥当であると確認できた． (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520853832837782656 (CiNii: 1520853832837782656)
9.	Kazuyoshi Kitaoka : レチノイン酸受容体アゴニストAm80の慢性投与はSAMP8マウスの空間学習能に作用する, 第26回老化促進モデルマウス(SAM)研究協議会, Jul. 2011.
10.	Kazuyoshi Kitaoka, Shun Aoi, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : 起立に伴う予測的頸動脈血流速度変化の検討-血流速度と血圧の同時記録による解析-, 第67回日本体力医学会中国・四国地方会大会, May 2011.
11.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : 起立に先行する総頸動脈血流速度の予測的変化, 第66回日本体力医学会中国・四国地方会大会, Nov. 2010.
12.	Kazuyoshi Kitaoka : Administration of retinoic acid receptor agonist Am80 improves the decrease of REM sleep in SAMP8 mice., 第24回老化促進モデルマウス(SAM)研究協議会, Jul. 2009. (Keyword) aging / sleep

Report:

1.	Kazuyoshi Kitaoka, 加藤浩介, 島岡未来子, 武田浩太郎, 谷川徹, 鶴田宏樹, 中原康之, 谷田貝孝, 湯川カナ and 和仁裕之 : 日本版 EntreComp「アントレプレナーシップ教育における 4 領域 8 能力」の検討について, イノベーション教育学会政策共創部会報告書, Dec. 2023.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Evaluation of simulative effect of adrenal steroids secretion by exposure to an extremely-low-frequency magnetic field. (Project/Area Number: 25870475 )
Does an activation of RAR improve Alzheimer disease by the expression of transthyretin? (Project/Area Number: 21700409 )
Search by Researcher Number (50432753)

Associate Professor : Kitaoka, Kazuyoshi

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)