Tokushima University / Educator and Researcher Directory --- Yoshizaki, Kazuo

Personal Web Page

https://researchmap.jp/read0043181 (researchmap)

Field of Study

○	Physiology

Subject of Study

○	イオン輸送·分泌現象·細胞増殖機序とエネルギー代謝に関する研究 (輸送現象, 体力医学, energy metabolism, nuclear magnetic resonance)

Book / Paper

Book:

1.	Kazuo Yoshizaki and 早野尚志 : 第2章 2-3 筋肉の実験MRS, インナービジョン, Tokyo, Mar. 2012.
2.	Kazuo Yoshizaki : 一般生理・細胞生理, KENPAKUSHA, Tokyo, 2005.
3.	Kazuo Yoshizaki and 内田孝 : 筋収縮, Nankodo, Tokyo, 2005.
4.	Kazuo Yoshizaki, 早野尚志 and 平川和文 : 分子の目でみた骨格筋の疲労, ナップ, Tokyo, 2003.

Academic Paper (Judged Full Paper):

1.	Motoshi Masuda, Takahiro Emoto, Asato Suzuki, Masatake Akutagawa, Tomoki Kitawaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shigeru Obara, Kazuo Yoshizaki, Shinsuke Konaka and Yohsuke Kinouchi : Evaluation of blood flow velocity waveform in common carotid artery using multi-branched arterial segment model of human arteries, Biomedical Signal Processing and Control, Vol.8, No.6, 509-519, 2013. (Summary) Arteriosclerosis is considered to be a major cause of cardiovascular diseases, which account for approximately 30% of the causes of death in the world. We have recently demonstrated a strong correlation between arteriosclerosis (arterial elasticity) and two characteristics: maximum systolic velocity (S1) and systolic second peak velocity (S2) of the common carotid artery flow velocity waveform (CCFVW). The CCFVW can be measured by using a small portable measuring device. However, there is currently no theoretical evidence supporting the causes of the relation between CCFVW and arterial elasticity, or the origin of the CCFVW characteristics. In this study, the arterial blood flow was simulated using a one-dimensional systemic arterial segments model of human artery in order to conduct a qualitative evaluation of the relationship between arterial elasticity and the characteristics of CCFVW. The simulation was carried out based on the discretized segments with the physical properties of a viscoelastic tube (the cross-sectional area at the proximal and terminal ends, the length, and the compliance per unit area of the tube (CS)). The findings obtained through this study revealed that the simulated CCFVW had shape similar characteristics to that of the measured CCFVW. Moreover, when the compliance CS of the model was decreased, the first peak of the simulated-CCFVW decreased and the second peak increased. Further, by separating the anterograde pulse wave and the reflected pulse wave, which form the CCFVW, we found that the decrease in the first peak of the simulated CCFVW was due to the arrival of a reflected pulse wave from the head after the common carotid artery toward the arrival of a anterograde pulse wave ejected directly from the heart and that the increase in the second peak resulted from the arrival of the peak of the reflected pulse wave from the thoracic aorta. These results establish that the CCFVW characteristics contribute to the assessment of arterial elasticity. (Keyword) Common carotid / Hemodynamics / Fluid simulation / Artery segments model / Artery elasticity (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bspc.2013.05.005 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84878849060 (DOI: 10.1016/j.bspc.2013.05.005, Elsevier: Scopus)
2.	Kazuyoshi Kitaoka, Noriyuki Shimizu, Koji Ono, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazunori Ishimura, Hiroyoshi Sei and Kazuo Yoshizaki : The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice, Neuropharmacology, Vol.72, 58-65, 2013. (Summary) The retinoic acid (RA, a vitamin A metabolite) receptor (RAR) is a transcription factor. Vitamin A/RA administration improves the Alzheimer's disease (AD)- and age-related attenuation of memory/learning in mouse models. Recently, a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) was identified as a key molecule in RA-mediated anti-AD mechanisms. We investigated the effect of chronic administration of the RAR agonist Am80 (tamibarotene) on ADAM10 expression in senescence-accelerated mice (SAMP8). Moreover, we estimated changes in the expression of the amyloid precursor protein (APP), amyloid beta (Aβ), and hairy/enhancer of split (Hes), which are mediated by ADAM10. Spatial working memory and the levels of a hippocampal proliferation marker (Ki67) were also assessed in these mice. ADAM10 mRNA and protein expression was significantly reduced in the hippocampus of 13-month-old SAMP8 mice; their expression improved significantly after Am80 administration. Further, after Am80 administration, the expression levels of Hes5 and Ki67 were restored and the deterioration of working memory was suppressed, whereas APP and Aβ levels remained unchanged. Our results suggest that Am80 administration effectively improves dementia by activating the hippocampal ADAM10-Notch-Hes5 proliferative pathway. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neuropharm.2013.04.009 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23624141 ● Summary page in Scopus @ Elsevier: 2-s2.0-84884865233 (DOI: 10.1016/j.neuropharm.2013.04.009, PubMed: 23624141, Elsevier: Scopus)
3.	Mitsuo Kitamura, 早野尚志 and Kazuo Yoshizaki : Re-design and evaluation of the NMR probes for living organs and tissues, Shikoku Acta Medica, Vol.69, No.1,2, 67-72, 2013. (Summary) We have constructed NMR signal detectors (probes) to measure the NMR spectra of living organs and tissues kept under physiological conditions. The probes consisted of non-magnetic aluminum alloy cylinder to support the detection coil made of cupper, mounted on a Teflon plate with acrylics plates and rods, however, the recovery time to the static magnetic field after turning off of the pulsed gradient field was more than 10 times longer than that of the micro-MRI probe available commercially. The re-design of our probes, such as acrylics cylinder to support the coil, together with readjustment of the eddy current compensation circuit, provided us the recovery time to the static field less than 1 msec, making it possible to measure the diffusion coefficient of Na+ ion using the pulsed field gradient spin echo method. The diffusion coefficient of Na+ ion in skeletal muscle isolated from bullfrog was 0.6 time larger than that in Ringer's solution, suggesting a high viscosity in the skeletal muscle. (Keyword) nmr probe / diffusion / Naイオン / muscle (Tokushima University Institutional Repository) ● Metadata: 109616 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050583647831092096 (Tokushima University Institutional Repository: 109616, CiNii: 1050583647831092096)
4.	Kazuyoshi Kitaoka, Mitsuo Kitamura, Shun Aoi, Noriyuki Shimizu and Kazuo Yoshizaki : Chronic exposure to an extremely low-frequency magnetic field induces depression-like behavior and corticosterone secretion without enhancement of the hypothalamicpituitaryadrenal axis in mice, Bioelectromagnetics, Vol.34, No.1, 43-51, 2013. (Summary) An extremely low-frequency magnetic field (ELF-MF) is generated by power lines and household electrical devices. Many studies have suggested an association between chronic ELF-MF exposure and anxiety and/or depression. The mechanism of these effects is assumed to be a stress response induced by ELF-MF exposure. However, this mechanism remains controversial. In the present study, we investigated whether chronic ELF-MF exposure (intensity, 1.5 mT; [corrected] total exposure, 200 h) affected emotional behavior and corticosterone synthesis in mice. ELF-MF-treated mice showed a significant increase in total immobility time in a forced swim test and showed latency to enter the light box in a light-dark transition test, compared with sham-treated (control) mice. Corticosterone secretion was significantly high in the ELF-MF-exposed mice; however, no changes were observed in the amount of the adrenocorticotropic hormone and the expression of genes related to stress response. Quantification of the mRNA levels of adrenal corticosteroid synthesis enzymes revealed a significant reduction in Cyp17a1 mRNA in the ELF-MF-exposed mice. Our findings suggest the possibility that high intensity and chronic exposure to ELF-MF induces an increase in corticosterone secretion, along with depression- and/or anxiety-like behavior, without enhancement of the hypothalamic-pituitary-adrenal axis. (Keyword) Adrenal Glands / Adrenocorticotropic Hormone / Animals / Behavior, Animal / Body Size / Corticosterone / Depression / Electromagnetic Fields / Emotions / Gene Expression Regulation, Enzymologic / Hypothalamo-Hypophyseal System / Male / Mice / Mice, Inbred ICR / Norepinephrine / Time Factors / Tyrosine 3-Monooxygenase (Link to Publication Site) ● Publication site (DOI): 10.1002/bem.21743 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22753092 ● Search Scopus @ Elsevier (PMID): 22753092 ● Search Scopus @ Elsevier (DOI): 10.1002/bem.21743 (DOI: 10.1002/bem.21743, PubMed: 22753092)
5.	Kazuyoshi Kitaoka, Mika Shimizu, Noriyuki Shimizu, Sachiko Chikahisa, Madoka Nakagomi, Koichi Shudo, Kazuo Yoshizaki and Hiroyoshi Sei : Retinoic acid receptor antagonist LE540 attenuates wakefulness via the dopamine D1 receptor in mice, Brain Research, Vol.1423, 10-16, 2011. (Summary) Vitamin A is a common lipophilic vitamin, and its function is mainly mediated by the binding of its metabolite retinoic acid to retinoic acid receptors (RARs) and retinoid X receptors. Recently, it was reported that the expression of the RARb (an RAR subtype) gene determines the contribution of the delta oscillation in the sleep electroencephalogram (EEG) patterns in mice. We also reported that 4-week dietary deficiency of vitamin A (VAD) causes the attenuation of delta power in sleep and spontaneous activity in mice. However, our previous study could not clarify whether the attenuation of delta power by VAD is attributed to the suppression of RARs. To address this problem, we investigated whether the chronic administration of LE540 (30mg/kg/day), an antagonist of RARs, for 1 or 4weeks attenuated EEG delta power during sleep in mice. Consequently, 4-week LE540 administration induced a significant attenuation of wakefulness and delta power in non-rapid eye movement sleep. Western blot analysis revealed a significant decrease in the expression of dopamine D1 receptor (D1DR) in the striatum and tyrosine hydroxylase in the midbrain of mice that were administered LE540 for 4weeks. High-performance liquid chromatography analysis of striatal tissue revealed a significant decrease in the homovanillic acid/dopamine ratio. Meanwhile, dopamine levels did not change in these mice. Our results suggest that the 4-week antagonism of RARs induces the attenuation of delta power. However, the attenuation of delta power may be elicited indirectly by the decrease of wakefulness followed by the hypo-expression of dopamine receptors especially D1DR. (Keyword) 3,4-Dihydroxyphenylacetic Acid / Animals / Corpus Striatum / Delta Rhythm / Dibenzazepines / Dopamine / Electroencephalography / Gene Expression Regulation / Homovanillic Acid / Male / Mice / Mice, Inbred C57BL / Receptors, Dopamine D1 / Receptors, Retinoic Acid / Sleep Stages / Time Factors / Wakefulness (Link to Publication Site) ● Publication site (DOI): 10.1016/j.brainres.2011.09.023 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22000589 ● Search Scopus @ Elsevier (PMID): 22000589 ● Search Scopus @ Elsevier (DOI): 10.1016/j.brainres.2011.09.023 (DOI: 10.1016/j.brainres.2011.09.023, PubMed: 22000589)
6.	Hirotaka Nishisako, Toshitaka Ikehara, Tairoh Shiraishi, Yuki Minami, Ichinose Hiromi Sasaki, Hitoshi Houchi, Kazuyoshi Kawazoe, Kazuo Minakuchi, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of a 1.5 T time-varying magnetic field on cell volume regulation of bovine adrenal chromaffin cells in hyposmotic media., The Journal of Medical Investigation : JMI, Vol.58, No.1-2, 95-105, 2011. (Summary) Effects of a time-varying magnetic field on cell volume regulation by hyposmotic stress in cultured bovine adrenal chromaffin cells were examined. Through regulatory volume decrease (RVD), cell volume of chromaffin cells that were incubated in a hypotonic medium initially increased, reached a peak and finally recovered to the initial value. Two hour exposure to a magnetic field and addition of cytochalasin D increased peak value and delayed return to initial value. Intracellular F-actin contents initially decreased but returned to normal levels after 10 sec. Two hour exposure to the magnetic field and addition of cytochalasin D continuously reduced the F-actin content. Results suggest that exposure to the magnetic field stimulated disruption of the actin cytoskeleton and that the disruption delayed the recovery to the volume prior to osmotic stress. (Keyword) Actins / Animals / calcium / Cattle / Cell Size / Cells, Cultured / Chromaffin Cells / Cytochalasin D / Hypotonic Solutions / Magnetics / Osmotic Pressure / Time Factors (Tokushima University Institutional Repository) ● Metadata: 111307 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.58.95 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21372493 ● Search Scopus @ Elsevier (PMID): 21372493 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.58.95 (Tokushima University Institutional Repository: 111307, DOI: 10.2152/jmi.58.95, PubMed: 21372493)
7.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : Feed-forward changes in carotid blood flow velocity during active standing., Neuroscience Letters, Vol.487, No.2, 240-245, 2011. (Summary) Orthostatic changes induce temporary loss of circulatory regulation. Feedback systems react to cardiovascular alterations to compensate for the instability. To clarify the existence of anticipatory cardiovascular regulation during active standing, we continuously recorded blood flow velocity (BFV) in the common carotid artery and cerebral blood volume (CBV) in healthy men. The maximum BFV value decreased significantly before standing in the reaction-time condition. The decrease significantly correlated with the change in systolic blood pressure that accompanies upright standing from a supine position. The anticipatory BFV decrease disappeared during self-paced standing, and all BFV parameters significantly declined after the self-paced standing. The CBV recording showed a significant increase in oxyhemoglobin levels before standing in the reaction-time condition. Our study suggests that some feed-forward cardiovascular regulation triggered by central command could be activated before standing, and it may play a functional role in the maintenance of cerebral perfusion during standing. (Keyword) Adult / Blood Flow Velocity / Blood Pressure / Carotid Artery, Common / Humans / Hypotension, Orthostatic / Male / Middle Aged / Posture / Reaction Time / Young Adult (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neulet.2010.10.030 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20970481 ● Search Scopus @ Elsevier (PMID): 20970481 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neulet.2010.10.030 (DOI: 10.1016/j.neulet.2010.10.030, PubMed: 20970481)
8.	Kazuyoshi Kitaoka, Atsuko Sano, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Disturbance of rapid eye movement sleep in senescence-accelerated mouse prone/8 mice is improved by retinoic acid receptor agonist Am80 (Tamibarotene)., Neuroscience, Vol.167, No.3, 573-582, 2010. (Summary) Senescence-accelerated mouse prone/8 (SAMP8) mice are known to exhibit age-related deterioration in sleep-wake architecture compared with senescence-accelerated mouse resistant/1 (SAMR1) mice. We investigated whether treatment with Am80 (Tamibarotene), a retinoic acid receptor agonist, would improve sleep in 9-10-month-old SAMP8 mice. One week of Am80 administration improved the decrease in rapid eye movement (REM) sleep shown by SAMP8 mice. Real-time RT-PCR analysis demonstrated an impairment in the hippocampal retinoid cascade (retinoic acid receptor alpha and transthyretin) in SAMP8 in comparison to SAMR1 mice. Am80 treatment induced an increase in mRNA expression in the vesicular acetylcholine transporter in the brainstem and transthyretin in the hippocampus. Furthermore, decreased cortical acetylcholine content in SAMP8 was improved by Am80 administration. Decreased non-REM sleep and delta oscillation were also observed in SAMP8 mice; however, this was not improved by Am80 administration. These results partially support the hypothesis that the effects of aging on sleep-wake architecture are improved by the activation of retinoic acid receptors. The improvement may be induced by the activation of the cholinergic pathway. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neuroscience.2010.01.059 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20138974 ● Search Scopus @ Elsevier (PMID): 20138974 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neuroscience.2010.01.059 (DOI: 10.1016/j.neuroscience.2010.01.059, PubMed: 20138974)
9.	Yohsuke Kinouchi and Kazuo Yoshizaki : 携帯型血流計装置の開発とその応用, Shikoku Acta Medica, Vol.64, No.5,6, 179-183, 2008.
10.	Akira Soda, Toshitaka Ikehara, Yohsuke Kinouchi and Kazuo Yoshizaki : Effects of exposure to an extremely low frequency-electromagnetic field on the cellular collagen with respect to signaling pathways in osteoblast-like cells., The Journal of Medical Investigation : JMI, Vol.55, No.3,4, 267-278, 2008. (Summary) The effect of exposure to extremely low frequency-electromagnetic field (ELF-EMF: 3 mT, 60 Hz) on differentiation of mouse osteoblast-like MC3T3-E1 cells was examined together with addition of insulin-like growth factor I (IGF-I). As a marker of the differentiation, the cellular collagen content was determined by the absorbance of Sirius red-stained cells measured at the wavelength of 510-520 nm with an imaging microspectroscopy. Exposure to ELF-EMF increased significantly the collagen in the cells. Treatment with PD98059, an inhibitor of extracellular signal-regulated kinase 1/2 (ERK1/2) activation, reduced the collagen in all of the cells examined on control, IGF-I addition and ELF-EMF exposure, however, PD98059 did not prevent the increase in the collagen caused by ELF-EMF exposure, and IGF-I also increased the collagen in the presence of the inhibitor. When phosphatidylinositol 3-kinase (PI3K) pathway was inhibited by LY294002, the increase in collagen induced by ELF-EMF exposure was accelerated, however, the increase in collagen observed by IGF-I addition was suppressed. Treatment with SB203580, an inhibitor of p38 mitogen-activated protein kinase (p38 MAPK), suppressed the increase in the collagen induced by ELF-EMF exposure, whereas IGF-I addition increased the collagen in the presence of the inhibitor. These results suggested that collagen synthesis stimulated by ELF-EMF exposure was carried out by the participation of p38 MAPK pathway, and that PI3K pathway may have the role to suppress the collagen synthesis induced by ELF-EMF exposure, and that the suppression of the PI3K pathway may allow the acceleration of the collagen synthesis. (Keyword) ELF-EMF / ERK1/2 / PI3K / collagen / osteoblast (Tokushima University Institutional Repository) ● Metadata: 110870 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.55.267 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18797142 ● Summary page in Scopus @ Elsevier: 2-s2.0-56749174709 (Tokushima University Institutional Repository: 110870, DOI: 10.2152/jmi.55.267, PubMed: 18797142, Elsevier: Scopus)
11.	Azhim Azran, Mizuki Katai, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Exercise Improved Age-associated Changes in the Carotid Blood Velocity Waveforms, Journal of Biomedical & Pharmaceutical Engineering, Vol.1, No.1, 17-26, 2007.
12.	Azhim Azran, Mizuki Katai, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Measurement of Blood Flow Velocity Waveforms in the Carotid, Brachial and Femoral Arteries during Head-up Tilt, Journal of Biomedical & Pharmaceutical Engineering, 2007.
13.	Shichijo Hiroe, Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Mitsuo Kitamura, Kazuo Yoshizaki, Yohsuke Kinouchi, Hiroshi Miyamoto and Aizawa Katsuo : Effects of ELF magnetic fields on signal transduction in osteoblast-like cells, 日本生体磁気学会誌特別号第20回日本生体磁気学会論文集, Vol.18, No.1, 166-167, 2005.
14.	Toshitaka Ikehara, Hisao Yamaguchi, Keiko Hosokawa, Hitoshi Houchi, Ki Ho Park, Kazuo Minakuchi, Hideki Kashimoto, Mitsuo Kitamura, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of a time-varying strong magnetic field on transient increase in Ca²⁺ release induced by cytosolic Ca²⁺ in cultured pheochromocytoma cells, Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1724, No.1-2, 8-16, 2005. (Summary) Exposure of pheochromocytoma (PC 12) cells to a time-varying 1.51 T magnetic field inhibited an increase in the intracellular Ca2+ concentration ([Ca2+]i) induced by addition of caffeine to Ca(2+)-free medium. This inhibition occurred after a 15-min exposure and was maintained for at least 2 h. [Ca2+]i sharply increased in cells loaded with cyclic ADP-ribose, and 2-h exposure significantly suppressed the increase. Addition of ATP induced a transient increase in intracellular Ca2+ release mediated by IP3 receptor, and this increase was strongly inhibited by the exposure. Results indicated that the magnetic field exposure strongly inhibited Ca2+ release mediated by both IP3 and ryanodine receptors in PC 12 cells. However, thapsigargin-induced Ca2+ influx (capacitative Ca2+ entry) across the cell membrane was unaffected. The ATP content was maintained at the normal level during the 2-h exposure, suggesting that ATP hydrolysis was unchanged. Therefore, Mg2+ which is known to be released by ATP hydrolysis and inhibit intracellular Ca2+ release may not relate the exposure-caused inhibition. Eddy currents induced in culture medium appear to change cell membrane properties and indirectly inhibit Ca2+ release from endoplasmic reticulum and other Ca2+ stores in PC 12 cells. (Keyword) ryanodine receptor / caffeine / cyclic ADP-ribose / time-varying magnetic field / eddy current (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbagen.2005.03.008 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15890451 ● Summary page in Scopus @ Elsevier: 2-s2.0-20444422530 (DOI: 10.1016/j.bbagen.2005.03.008, PubMed: 15890451, Elsevier: Scopus)
15.	Toshitaka Ikehara, Ki Ho Park, Hisao Yamaguchi, Keiko Hosokawa, Hitoshi Houchi, Mami Azuma, Kazuo Minakuchi, Hideki Kashimoto, Mitsuo Kitamura, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of Time-Varying Strong Magnetic Fields on Rerease of Cytosolic Free Ca²⁺ from Intracellular Stores in Cultured Bovine Adrenal Chromaffin Cells, Bioelectromagnetics, Vol.23, No.7, 505-515, 2002. (Summary) This study was made to explain the mechanisms for the effects of exposure to a time varying 1.51 T magnetic field on the intracellular Ca(2+) signaling pathway. The exposure inhibited an increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in bovine chromaffin cells induced by addition of bradykinin (BK) to a Ca(2+) free medium. The exposure did not change BK induced production of inositol 1,4,5-trisphosphate (IP(3)). [Ca(2+)](i) was markedly increased in IP(3) loaded cells, and this increase was inhibited by the magnetic field exposure. A similar increase in [Ca(2+)](i) by other drugs, which stimulated Ca(2+) release from intracellular Ca(2+) stores, was again inhibited by the same exposure. However, transmembrane Ca(2+) fluxes caused in the presence of thapsigargin were not inhibited by the magnetic field exposure in a Ca(2+) containing medium. Inhibition of the BK induced increase in [Ca(2+)](i) by the exposure for 30 min was mostly recovered 1 h after exposure ended. Our results reveal that the magnetic field exposure inhibits Ca(2+) release from intracellular Ca(2+) stores, but that BK bindings to BK receptors of the cell membrane and intracellular inositol IP(3) production are not influenced. (Keyword) magnetic field / cell physiology (Link to Publication Site) ● Publication site (DOI): 10.1002/bem.10043 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12224054 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036778437 (DOI: 10.1002/bem.10043, PubMed: 12224054, Elsevier: Scopus)
16.	Toshitaka Ikehara, Ki Ho Park, Hisao Yamaguchi, Keiko Hosokawa, Kazuo Yoshizaki, Hiroshi Miyamoto, Katsuo Aizawa and Yohsuke Kinouchi : Effects on Rb⁺(K⁺) Uptake of HeLa Cells in a High K⁺ Medium of Exposure to a Switched 1.7 Tesla Magnetic Field, Bioelectromagnetics, Vol.21, No.3, 228-237, 2000. (Summary) Effects of a switched, time-varying 1.7 T magnetic field on Rb(+)(K+) uptake by HeLa S3 cells incubated in an isosmotic high K(+) medium were examined. The magnetic flux density was varied intermittently from 0.07-1.7 T at an interval of 3 s. K(+) uptake was activated by replacement of normal medium by high K(+) medium. A membrane-permeable Ca(2+) chelating agent (BAPTA-AM) and Ca(2+)-dependent K(+) channel inhibitors (quinine, charibdotoxin, and iberiotoxin) were found to reduce the Rb(+)(K+) uptake by about 30-40%. Uptake of K(+) that is sensitive to these drugs is possibly mediated by Ca(2+)-dependent K(+) channels. The intermittent magnetic field partly suppress ed the drug-sensitive K(+) uptake by about 30-40% (P < 0.05). To test the mechanism of inhibition by the magnetic fields, intracellular Ca(2+) concentration ([Ca(2+)]c) was measured using Fura 2-AM. When cells were placed in the high K(+) medium, [Ca(2+)]c increased to about 1.4 times the original level, but exposure to the magnetic fields completely suppressed the increase (P < 0.01). Addition of a Ca(2+) ionophore (ionomycin) to the high K(+) medium increased [Ca(2+)]c to the level of control cells, regardless of exposure to the magnetic field. But the inhibition of K(+) uptake by the magnetic fields was not restored by addition of ionomycin. Based on our previous results on magnetic field-induced changes in properties of the cell membrane, these results indicate that exposure to the magnetic fields partly suppresses K(+) influx, which may be mediated by Ca(2+)-dependent K(+) channels. The suppress ion of K(+) fluxes could relate to a change in electric properties of cell surface and an inhibition of Ca(2+) influx mediated by Ca(2+) channels of either the cell plasma membrane or the inner vesicular membrane of intracellular Ca(2+) stores. (Keyword) calcium / Cell Membrane / Charybdotoxin / Chelating Agents / Culture Media / Egtazic Acid / Electromagnetic Fields / electrophysiology / Environmental Exposure / Fluorescent Dyes / Fura-2 / HeLa Cells / Humans / Intracellular Membranes / Ionomycin / Ionophores / Magnetics / Peptides / potassium / Potassium Channel Blockers / Potassium Channels / Quinine / Rubidium (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10723022 ● Search Scopus @ Elsevier (PMID): 10723022 (PubMed: 10723022)
17.	Ki Ho Park, Akira Soda, Hisao Yamaguchi, Yohsuke Kinouchi and Kazuo Yoshizaki : Effects of ELF Magnetic Fields on Collagen Synthesis in Osteoblasts, Electricity and Magnetism in Biology and Medicine, 457-460, 1999.
18.	Yasuhiro Fukui, Ki Ho Park, Yohsuke Kinouchi, Keiko Hosokawa, Toshitaka Ikehara, Hisao Yamaguchi and Kazuo Yoshizaki : ELF磁界による歯根膜誘導電流の解析歯槽骨再生の基礎, The Journal of the Japanese Society of Magnetic Applications in Dentistry, Vol.8, No.1, 41-47, 1999.
19.	Ki Ho Park, Toshitaka Ikehara, Hisao Yamaguchi, Hitoshi Houchi, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : 副賢髓質クロマフイン細胞のアセチルコリンによる細胞内カルシウムイオン増加に及ぼす変動強磁界の影響, The Journal of the Japanese Society of Magnetic Applications in Dentistry, Vol.8, No.1, 35-40, 1999.
20.	Toshitaka Ikehara, Ki Ho Park, Hitoshi Houchi, Hisao Yamaguchi, Keiko Hosokawa, masayuki Shono, Kazuo Minakuchi, Toshiaki Tamaki, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of a Time-varying Strong Magnetic Field on Transient Increase in Cytosolic Free Ca²⁺ Induced by Bradykinin in Cultured Bovine Adrenal Chromaffin Cells, FEBS Letters, Vol.435, No.2-3, 229-232, 1998. (Summary) We tested the effects of exposure to a time-varying magnetic field changing between 0.07 and 1.7 T at an interval of 3 s on transient increase in intracellular Ca2+ stimulated by bradykinin in bovine adrenal chromaffin cells. Addition of bradykinin induced the increase in intracellular Ca2+ within a few minutes. The exposure to the magnetic field perfectly suppressed the increase in intracellular Ca2+ in Ca2+-free medium. The inhibition occurred for 15 min when the maximum magnetic flux density was more than 1.4 T. These results suggest that the exposure inhibits Ca2+ release from intracellular Ca2+ stores. (Keyword) Animals / Bradykinin / calcium / Cattle / Chromaffin Cells / Electromagnetic Fields / signal transduction / Time Factors (Link to Publication Site) ● Publication site (DOI): 10.1016/S0014-5793(98)01078-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9762915 ● Summary page in Scopus @ Elsevier: 2-s2.0-18244413305 (DOI: 10.1016/S0014-5793(98)01078-3, PubMed: 9762915, Elsevier: Scopus)
21.	Ki Ho Park, Toshitaka Ikehara, Hitoshi Houchi, Yohsuke Kinouchi, Hisao Yamaguchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of time-varying magnetic fields on Ca2+ concentration in chromaffin cell, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.11, No.1, 160-161, 1998.
22.	Toshiataka Ikehara, Park Ho Ki, Hitoshi Houchi, Keiko Hosokawa, Masayuki Shono, Kazuo Minakuchi, Toshiaki Tamaki, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of a time-varying strong magnetic field on transient increase in cytosolic free-Ca²⁺ induced by bradykinin in cultured bovine adrenal chromaffin cells., FEBS Letters, Vol.435, 229-232, 1998.
23.	Ki Ho Park, Yohsuke Kinouchi, Toshitaka Ikehara, Hisao Yamaguchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 変動強磁界が及ぼす細胞膜1価イオン輸送への影響, 日本生体磁気学会論文誌, Vol.9, No.2, 55-62, 1997.
24.	Ki Ho Park, 荘田彰, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : ELF領域の正弦波交流磁界が骨芽細胞に及ぼす影響, 第11回日本生体磁気学会大会, 1996.

Academic Paper (Unrefereed Paper):

1.	Yuki Minami, Toshitaka Ikehara, Keiko Hosokawa, Hisao Yamaguchi, Keisuke Ishizawa, Masayuki Shono, Kazuyoshi Kawazoe, Kazuo Minakuchi, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effect of time-varying magnetic field on cell volume regulation of adrenal chromaffin cells, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.19, No.1, 156-157, 2006.

Academic Letter:

1.	七條裕衣, Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki, Yohsuke Kinouchi, Hiroshi Miyamoto and 會沢勝夫 : ImSpecter法による培養骨牙細胞に及ぼすELF変動磁界の影響, Technical Report of IEICE, MBE, Vol.32, 49-52, 2004. (Keyword) ImSpecter法 / 培養骨牙細胞 / ELF変動磁界

Review, Commentary:

1.	早野尚志 and Kazuo Yoshizaki : 分子機能情報を活用した医学生理学研究の展開 31P-NMRスペクトロスコピーによる分子情報の活用, Shikoku Acta Medica, Vol.64, No.5,6, 164-169, Dec. 2008. (Tokushima University Institutional Repository) ● Metadata: 110245 (Tokushima University Institutional Repository: 110245)

Proceeding of International Conference:

1.	Motoshi Masuda, Masatake Akutagawa, Takahiro Emoto, Tomoki Kitawaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shigeru Obara, Kazuo Yoshizaki, Shinsuke Konaka and Yohsuke Kinouchi : Study on blood flow velocity patterns at carotid using one-dimensional computer simulation of humman arteries, Proceedings of the IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI 2012), 651-654, Shenzhen, Jan. 2012. (Summary) 総頸動脈血流速度波形と動脈弾性の関係について，1次元流体解析モデルを用いて検討している．動脈モデルはヒトの全身の主要な動脈を多枝セグメントモデルとして構築したものを用い，動脈弾性を変化させた時の総頸動脈の血流速度波形を求めた結果，動脈弾性の変化により血流速度波形が変化することを示した．これにより総頸動脈の血流速度波形を調べることにより動脈硬化を評価することができる可能性を示した． (Link to Publication Site) ● Publication site (DOI): 10.1109/BHI.2012.6211667 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84864244682 (DOI: 10.1109/BHI.2012.6211667, Elsevier: Scopus)
2.	Koki Aoyama, Takahiro Emoto, Masatake Akutagawa, Motoshi Masuda, Shota Minato, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : Evaluating the atherosclerosis based on the blood flow velocity waveform of common carotid artery, Proceedings of the IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI 2012), 655-658, Shenzhen, Jan. 2012. (Summary) 頸動脈血流速度波形は動脈硬化等の循環器系の状態を反映していることが知られている．また動脈硬化のスクリーニング指標として，CAVIが実用に供されている．本研究では頸動脈血流波形から自動抽出可能な動脈弾性指標の提案を目的とし，評価の妥当性を確認するため，血流速度と CAVI の測定を行い，提案した指標と CAVI の関係を調べた．また，動脈は加齢により硬化する事や，男性に比べ閉経前の女性は軟らかい事から，提案した指標と年齢の関係や性差について調べた． (Link to Publication Site) ● Publication site (DOI): 10.1109/BHI.2012.6211668 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84864258384 (DOI: 10.1109/BHI.2012.6211668, Elsevier: Scopus)
3.	Kazuyoshi Kitaoka, Shimizu Mika, Shimizu Noriyuki, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Retinoic acid receptors antagonist LE540 atenuates EEG delta power during sleep via dopamine D1 receptor in mice, Neuroscience 2010, San Diego, Nov. 2010.
4.	Kazuyoshi Kitaoka, Shimizu Mika, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Four-week administration of retinoic acid receptors antagonist LE540 attenuates EEG delta power during sleep in mice, The 6Th Congress of Asian Sleep Research Society, Oct. 2009.
5.	Yoshiki Utsunomiya, Azhim Azran, Asato Suzuki, Masatake Akutagawa, Takahiro Emoto, Kazuo Yoshizaki, Shigeru Obara, Hiroyuki Tanaka and Yohsuke Kinouchi : Influence of Respiration on Variability of Peak Systolic Blood Flow Velocity in Common Carotid Artery: Preliminary Study, Proceedings of 2009 World Congress on Medical Physics and Biomedical Engineering, Vol.25, No.7, 796-799, Munich, Sep. 2009.
6.	Kazuyoshi Kitaoka, Atsuko Sano, Sachiko Chikahisa, Kazuo Yoshizaki and Hiroyoshi Sei : Administration of Am80, an agonist of retinoic acid receptor, improves the aging-related decrease of REM sleep in SAMP8 mice, 36th International Congress of Physiological Sciences, Aug. 2009.
7.	Kazuo Yoshizaki, Hayano Takashi and Arizono Naoki : 1H-NMR STUDY ON HISTAMINE OF MAST CELLS AND EXOCYTOSIS., 36th International Congress of Physiological Sciences, Jul. 2009.
8.	Azhim Azran, Masatake Akutagawa, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka and Yohsuke Kinouchi : Wireless blood velocity apectra measurement system for healthcare evaluation: Reference data, Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 1427-1430, Vancouver, Aug. 2008.
9.	Higashiyama Yukitaka, Toshitaka Ikehara, Yohsuke Kinouchi, Masatake Akutagawa, Kazuo Yoshizaki, Morimoto Toshifumi and Inoue Tadaaki : EFFCTS OF MICRO WAVE ELECTROMAGNETIC FIELDS (438.5MHZ) ON TRANSIENT INCREASE IN INTRACELLULAR CA²⁺ IN BOVINE ADRENAL CHROMAFFIN CELLS, The Bioelectromagnetics Society 30th Annual Meeting, 367-368, San Diego, Jun. 2008.
10.	Toshitaka Ikehara, Shiraishi Tairho, Nishisako Hirotaka, Hisao Yamaguchi, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki, Kazuyoshi Kawazoe, Kazuo Minakuchi, Yohsuke Kinouchi and Hiroshi Miyamoto : EFFECTS OF TIME-VARYING MAGNETIC FIELD ON REGULATORY VOLUME DECREASE IN BOVINE ADRENAL CHROMAFFIN CELLS, The Bioelectromagnetics Society 30th Annual Meeting, 368-369, San Diego, Jan. 2008.
11.	Azhim Azran, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Assessments of Carotid Velocity Waveform in Sedentary and Regular Execise-trained Men, Proceedings of the International Symposium on Biological and Physiological Engineering /The 22nd SICE Symposium on Biological and Physiological Engineering, Vol.1, No.1, 284-287, Harbin, Jan. 2008. (Keyword) Portable blood velocimeter / blood velocity waveform / aging patterrn / regular exercise training
12.	Toshitaka Ikehara, Nishisako Hirotaka, Shiraishi Tairoh, Hisao Yamaguchi, Masayuki Shono, Mitsuo Kitamura, Kazuyoshi Kawazoe, Kazuo Minakuchi, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of a time-varying magnetic field on bovine adrenal chromaffin cells., Proceedings of the International Symposium on Biological and Physiological Engineering /The 22nd SICE Symposium on Biological and Physiological Engineering, 117-118, Harbin, Jan. 2008.
13.	Higashiyama Yukitaka, Toshitaka Ikehara, Yohsuke Kinouchi, Masatake Akutagawa, Kazuo Yoshizaki, Morimoto Toshifumi and Inoue Tadaaki : Effects of 438.5 MHz electromagnetic fields on transient increase in intracellular Ca²⁺ in adrenal chromaffin Cells, International Conference on Magneto-Science(ICMS2007), 92, Hiroshima, Nov. 2007.
14.	Azhim Azran, Akioka Kohei, Masatake Akutagawa, Hirao Yuji, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Tanaka Hiroyuki, Hisao Yamaguchi and Yohsuke Kinouchi : Effects of Aging and Exercise Training on the Common Carotid Blood Velocities in Healthy Men, 29th IEEE EMBS Annual International Conference, 989-993, Lyon, France, Aug. 2007. (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18002126 ● Summary page in Scopus @ Elsevier: 2-s2.0-57649233432 (PubMed: 18002126, Elsevier: Scopus)
15.	Azhim Azran, Kohei Akioka, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Effect of Gender on Blood Flow Velocities and Blood Pressure: Role of Body Weight and Height, 29th IEEE EMBS Annual International Conference, 967, Lyon, France, Aug. 2007. (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18002119 ● Summary page in Scopus @ Elsevier: 2-s2.0-57649143534 (PubMed: 18002119, Elsevier: Scopus)
16.	Toshitaka Ikehara, Yuki Minami, Shiota Naoko, Hisao Yamaguchi, Masayuki Shono, Mitsuo Kitamura, Kazuyoshi Kawazoe, Kazuo Minakuchi, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : EFFECTS OF A TIME-VARYING MAGNETIC FIELD ON CELL VOLUME REGULATION OF CULTURED BOVINE ADRENAL CHROMAFFIN CELLS, Abstract Book The Bioelectromaginetics Society 29th Annual Meeting, 375-376, Kanazawa, Jun. 2007.
17.	Azhim Azran, Mizuki Katai, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Measurement of Blood Flow Velocity Waveforms in the Carotid, Brachial and Femoral Arteries during Postural Change, Proceedings of the Intenational Conference on Biomedical and Pharmaceutical Engineering, 438-442, Singapore, Dec. 2006.
18.	Azhim Azran, Mizuki Katai, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Exercise Training Improved Blood Flow Velocity and Autonomic Nervous Activity, Proceedings of the Intenational Conference on Biomedical and Pharmaceutical Engineering, 517-522, Singapore, Dec. 2006.
19.	Azhim Azran, Mizuki Katai, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Blood Flow Velocities in Common Carotid Artery Changes with Age and Exercise, Proceedings of the Intenational Conference on Biomedical and Pharmaceutical Engineering, 523-530, Singapore, Dec. 2006.
20.	Mizuki Katai, Azhim Azran, Tatsuaki Kamiya, Masatake Akutagawa, Yuji Hirao, Hisao Yamaguchi, Kazuo Yoshizaki, Masahiro Nomura, Shigeru Obara, Hiroyuki Tanaka and Yohsuke Kinouchi : Measurement and analysis of carotid blood flow and ECG in cardiac, Proceedings of 2006 World Congress on Medical Physics and Biomedical Engineering, Seoul, Korea, August 27-September 1, 2006, Vol.1, 3359-3362, Seoul, Aug. 2006.
21.	Azhim Azran, Tatsuaki Kamiya, Mizuki Katai, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Masahiro Nomura, Shigeru Obara, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Changes in the common carotid blood velocity waveform for exercise training, Proceedings of 2006 World Congress on Medical Physics and Biomedical Engineering, Seoul, Korea, August 27-September 1, 2006, Vol.1, Seoul, Aug. 2006.
22.	Tatsuaki Kamiya, Azhim Azran, Masatake Akutagawa, Hisao Yamaguchi, Masahiro Nomura, Shigeru Obara, Hiroyuki Tanaka, Kazuo Yoshizaki and Yohsuke Kinouchi : Detection of a maximum blood flow velocity variation in the carotid artery during physical exercise using BPNN, Proceedings of 2006 World Congress on Medical Physics and Biomedical Engineering, Seoul, Korea, August 27-September 1, 2006, Vol.1, 3271-3274, Seoul, Aug. 2006.
23.	Toshitaka Ikehara, Hiromi Sasaki, Yuki Minami, Hisao Yamaguchi, Keiko Hosokawa, Kazuyoshi Kawazoe, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of a time-varying magnetic field on intracellular organells and actin filaments of bovine adrenal chronmaffin cells, Abstract Book The Bioelectromaginetics Society 28th Annual Meeting, 81-82, Cancun, Jun. 2006.
24.	Azhim Azran, Kamiya Tatsuaki, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi, Kazuo Yoshizaki and Hiroyuki Tanaka : Measuring and Analyzing the Variations of Carotid Blood Velocity and Heart Rate during Physical Exercise Stress for Diagnosis of Cardiovascular system, Proceedings of the 12th International Conference on Biomedical Engineering, Singapore, December 7-10, 2005, Vol.1, Singapore, Dec. 2005.
25.	Yusuke Uchigami, Naohiro Kadowaki, Toshitaka Ikehara, Hitoshi Houchi, Hisao Yamaguchi, Kazuo Yoshizaki, Hiroshi Miyamoto and Yohsuke Kinouchi : Effects of Time-Varying Magnetic Fields on Transient increase in Intracellular Ca²⁺ Concentration of Cultured Cells, Proceedings of the 27th Annual Conference of the IEEE-EMBS, Vol.7, 446-448, Shanghai, Sep. 2005. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-33846902362 (Elsevier: Scopus)
26.	Jun Yamaguchi, Azhim Azran, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : A Change of Blood Flow during Strenuous Physical Exercises Using Cycle Ergometer, Proceedings of the 27th Annual Conference of the IEEE-EMBS, Shanghai, Sep. 2005. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-33846938824 (Elsevier: Scopus)
27.	Yoshinori Nitta, Masatake Akutagawa, Toshiya Okahisa, Hiroshi Miyamoto, Yoshiaki Onishi, Kazuo Yoshizaki, Masaji Nishimura and Yohsuke Kinouchi : Short term prediction of Ht value using BPNN during LCAP, Proceedings of the 27th Annual Conference of the IEEE-EMBS, Vol.7, 4560-4563, Shanghai, Sep. 2005. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-33846897208 (Elsevier: Scopus)
28.	Azhim Azran, Yamaguchi Jun, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi, Kazuo Yoshizaki, Susumu Ito and Masahiro Nomura : Monitoring Carotid Blood Flow and ECG for Cardiovascular Disease in Elder Subjects, Proceedings of the 27th Annual Conference of the IEEE-EMBS, Vol.7, 5495-5498, Shanghai, Sep. 2005. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-33846912734 (Elsevier: Scopus)
29.	Toshitaka Ikehara, Hiromi Sasaki, Tadahiro Teramoto, Hitoshi Houchi, Keiko Hosokawa, Hisao Yamaguchi, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of a time-varying magnetic field on intracellular Ca²⁺ movements of cultured bovine adrenal chromaffin cells, Bioelectromagnetics 2005 Abstract Collection, 405-406, Dublin, Jun. 2005. (Keyword) magnetic field / Ca2+ / Endoplasmic reticulum / actin / chromaffin cells
30.	Hisao Yamaguchi, Keiko Hosokawa, Hiroe Shichijo, Mitsuo Kitamura, Akira Soda, Toshitaka Ikehara, Yohsuke Kinouchi, Kazuo Yoshizaki, Hiroshi Miyamoto and Katsuo Aizawa : Effects of ELF magnetic field on signal transduction for the deffrentiation of osteoblast-like signal transduction for the deffrentiation of osteoblast-like cells, Bioelectromagnetics 2005 Abstract Collection, 348, Dublin, Jun. 2005.
31.	Azhim Azran, Jun Yamaguchi, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : Measurement of blood flow in the carotid artery during physical exercise using bicycle ergometer, Proceedings of 6th Asian-Pacific Conference on Biomedical Engineering, Tsukuba, Apr. 2005.
32.	Azhim Azran, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : Variations of the Maximum Blood Flow Velocity in the Carotid, Brachial and Femoral Arteries in a Passive Postural Changes by a Doppler Ultrasound Method, Proceedings of the 26th Annual International Conference of the IEEE EMBS, Vol.26, 3708-3711, San Francisco, Sep. 2004. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-11144282721 (Elsevier: Scopus)
33.	Toshitaka Ikehara, Tadahiro Teramoto, Hitoshi Houchi, Keiko Hosokawa, Hisao Yamaguchi, Yohsuke Kinouchi, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of a switched 1.5 tesla magnetic field on intracellular Ca²⁺ signaling pathways of adrenal chromaffin cells, Proceedings of 26th BEMS Meeting, Washington, D.C., Jun. 2004.
34.	Hisao Yamaguchi, Keiko Hosokawa, Hiroe Shichijo, Mitsuo Kitamura, Akira Soda, Toshitaka Ikehara, Yohsuke Kinouchi, Kazuo Yoshizaki, Hiroshi Miyamoto and Katsuo Aizawa : Effects of ELF magnetic fields on signal for differentiation of cultured osteoblastic cells by multispectral imaging system., Proceedings of 26th BEMS Meeting, 216, Washington, D.C., Jun. 2004.
35.	Toshitaka Ikehara, Ki Ho Park, Keiko Hosokawa, Hisao Yamaguchi, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of Time-Varying Magnetic Field on Intracellular Energy Metabolism of Adrenal Chromaffin Cells, Proceedings of 25th BEMS Meeting, 292, Maui, Hawaii, Jun. 2003.
36.	Hisao Yamaguchi, Keiko Hosokawa, Yoshiko Nakano, Ki Ho Park, Toshitaka Ikehara, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of ELF Magnetic Fields on Regulation in Cultured Osteoblast-Like Cells, Proceedings of 25th BEMS Meeting, 288, Maui, Hawaii, Jun. 2003.
37.	Yoshiko Nakano, Keiko Hosokawa, Hisao Yamaguchi, Park Ho Ki, Toshitaka Ikehara, Mitsuo Kitamura, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Design of an Uniform Magnetic Field Exposure System for Experiments of Biological Effects of Magnetic Fields on Culture Cells, The Japanese Society of Magnetic Applications in Dentistry (JSMAD)The Second International Conference on Magnetic Applications in Dentistry, Feb. 2003.
38.	Toshitaka Ikehara, Ki Ho Park, Keiko Hosokawa, Mitsuo Kitamura, Yohsuke Kinouchi, Kazuo Yoshizaki, Hisao Yamaguchi and Hiroshi Miyamoto : Effects of Time-Varying Magnetic Fields on Increase in Intracellular Free Ca²⁺ in Cultured Cells, Proc. of International Symposium on Bioelectromagnetics, 134-137, Kyoto, Oct. 2002. (Keyword) Magnetic Field / cell
39.	Yuji Hirao, Yohsuke Kinouchi, Takashi Kuroda, Hisao Yamaguchi, Kazuo Yoshizaki and Dali Zhang : Analysis of Effects of Nonuniform Beam Profile on Doppler Power Spectrum and Mean Velocity, Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol.1, 201, Istanbul, Oct. 2001. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0035781223 (Elsevier: Scopus)
40.	Yuji Hirao, Yohsuke Kinouchi, Takashi Kuroda, Hisao Yamaguchi, Kazuo Yoshizaki and Dali Zhang : Synchronized Measurement of Maximum Blood Flow Velocities in Carotid, Brachial and Femoral Arteries, and ECG in Human Posture Changes, Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol.1, 139-142, Istanbul, Oct. 2001. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0035781340 (Elsevier: Scopus)
41.	Toshitaka Ikehara, Keiko Hosokawa, Hitoshi Houchi, Mitsuo Kitamura, Yohsuke Kinouchi, Hiroshi Miyamoto, Ryohei Murato, Ki Ho Park, Hisao Yamaguchi and Kazuo Yoshizaki : Effects of magnetic fields on intracellular Ca²⁺ mobilization and differentiation of neural cells, XXXIV International Congress of Physiological Sciences Abstract Book, a1599, Christchurch, New Zealand, Aug. 2001.
42.	Ki Ho Park, Ryohei Murato, Toshitaka Ikehara, Keiko Hosokawa, Hitoshi Houchi, Hisao Yamaguchi, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of Time-Varying Magnetic Fields on Neuronal Cells, Conference Digest of Asia-Pacific Radio Science Conference, 405, Tokyo, Aug. 2001.
43.	Ki Ho Park, Toshitaka Ikehara, Hitoshi Houchi, Keiko Hosokawa, Hisao Yamaguchi, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of Time-Varying Strong Magnetic Fields on Cellular Functions, Conference Digest of Asia-Pacific Radio Science Conference, 257, Tokyo, Aug. 2001.
44.	Dali Zhang, Yuji Hirao, Takashi Kuroda, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : Effcts of a Power Spectrum and its Broadning on the Estimation of Mean Blood Velocity Using a Nonuniform Ultrasound Beam, Proceedings of The International Technical Conference on Circuits/Systems, Computers and Communications, Vol.2, 1268-1271, Tokushima, Jul. 2001.
45.	Keiko Hosokawa, Hisao Yamaguchi, Yoshiko Nakano, Ki Ho Park, Akira Soda, Yohsuke Kinouchi, Toshitaka Ikehara, Kazuo Yoshizaki and Hiroshi Miyamoto : Different Effects of ELF Magnetic Fields and Triiodothyronine on Induction of Differentiation in Cultured Osteoblasts, Proceeding of Annual Meeting of Bioelectromagnetics Society, 197-198, St. Paul, USA, Jun. 2001.
46.	Ki Ho Park, Ryohei Murato, Toshitaka Ikehara, Hitoshi Houchi, Hisao Yamaguchi, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of Intermittent Magnetic Fields on Transient Increase in Free Cytosolic Ca²⁺ Induced by Acetylcholine in Cultured Chromaffin Cells, Proceeding of Annual Meeting of Bioelectromagnetics Society, 198-199, St. Paul, USA, Jun. 2001.
47.	Toshitaka Ikehara, Ki Ho Park, Hideki Kashimoto, Hitoshi Houchi, Hisao Yamaguchi, Keiko Hosokawa, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of Time-Varying Magnetic Field on Ca²⁺ Release from Intracellular Ca²⁺ store of Adrenal Chromaffin Cells, Proceeding of Annual Meeting of Bioelectromagnetics Society, 167-168, Munich, Germany, Jun. 2000.
48.	Keiko Hosokawa, Hisao Yamaguchi, Hideki Kashimoto, Ki Ho Park, Akira Soda, Yohsuke Kinouchi, Toshitaka Ikehara, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of ELF Magnetic Fields on Regulation of Signal Transduction with Differentiation of Cultured Osteoblasts, Proceeding of Annual Meeting of Bioelectromagnetics Society, 183, Munich, Germany, Jun. 2000.
49.	Hideki Kashimoto, Ki Ho Park, Toshitaka Ikehara, Hitoshi Houchi, Yohsuke Kinouchi, Hisao Yamaguchi, Akira Soda, Kazuo Yoshizaki and Hiroshi Miyamoto : Effect of Switched Strong Magnetic Field on Ca²⁺ Release from Intracellular Vesicles of Cultured Chromaffin Cells, Proceedings of Annual Meeting of Bioelectromagnetics Society, 106, Long Beach, USA, Jun. 1999.
50.	Keiko Hosokawa, Hisao Yamaguchi, Hideki Kashimoto, Ki Ho Park, Akira Soda, Yohsuke Kinouchi, Toshitaka Ikehara, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of ELF Magnetic Fields on Regulation of Ca²⁺ Concentration in Cultured Osteoblasts, Proceedings of Annual Meeting of Bioelectromagnetics Society, 194-195, Long Beach, USA, Jun. 1999.
51.	Park Ho Ki, Toshitaka Ikehara, Hitoshi Houchi, Hisao Yamaguchi, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of a Time-Varying Strong Magnetic Fields on Ca²⁺ Concentration in Cultured Bovine Adrenal Chromaffin Cells, Proceedings of the 20th Annual International Conference of the IEEE-EMBS, Vol.20, 3290-3293, Hong Kong, Oct. 1998.
52.	Ki Ho Park, Yohsuke Kinouchi, Toshitaka Ikehara, Hisao Yamaguchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Influences of time-varying 1.6T magnetic fields on K+ uptake in cultured HeLa cells, Medical & Biological Engineering & Computing, Vol.35, No.Suppl. Part 1, 40, Nice, France, Sep. 1997.
53.	Toshitaka Ikehara, Katsuo Aizawa, Keiko Hosokawa, Hisao Yamaguchi, Ki Ho Park, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Analysis of magnetic field effects on Ca²⁺-dependent K⁺ uptake into HeLa cells using FT-IR spectra, XXXIIIInternational Congress of Physiological Sciences, St.Petersburg, Russia, Jun. 1997.
54.	Ki Ho Park, Akira Soda, Hisao Yamaguchi, Yohsuke Kinouchi and Kazuo Yoshizaki : Effects of ELF magnetic fields on collagen synthesis in osteoblasts, Abstracts of Second World Congress for Electricity and Magnetism in Biology and Medicine, 216-217, Bologna, Jun. 1997.

Proceeding of Domestic Conference:

1.	多田亜梨沙, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Akihiro Inagaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : 超音波ドプラ法を用いた血流速度測定装置のディジタル化に関する検討, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, No.14-13, 241, Sep. 2014. (Summary) 頸動脈血流速度波形を測定することによって動脈硬化の程度など循環器系の様々な状態を知ることができることがわかってきた．小型血流速度測定装置が普及すると日常的に循環器の状態を測定することができるようになり，健康長寿社会へも繋げることもできるかもしれない．そのためには低雑音で扱いの容易な測定装置の開発が必須である．本研究ではFPGAなどのディジタル回路を用いて回路の主要部分再設計し，低雑音の測定装置の開発を試みた．
2.	早野尚志, Mitsuo Kitamura and Kazuo Yoshizaki : --, 第41回日本磁気共鳴医学会大会, Sep. 2013.
3.	Tomohiro Yoshida, Shun Aoi, Kazuyoshi Kitaoka, Mitsuo Kitamura, Noriyuki Shimizu and Kazuo Yoshizaki : Chronic exposure to extremely low-frequency magnetic field stimulates corticosteroid secretion in both mice and Y-1 cell line, The 90th annual meeting of Physiological Society of Japan, Mar. 2013.
4.	Kazuyoshi Kitaoka, Mitsuo Kitamura, Shun Aoi, Tomohiro Yoshida, Noriyuki Shimizu and Kazuo Yoshizaki : 極低周波変動磁界慢性暴露による副腎皮質ホルモンの分泌増強作用, 第64回日本生理学会中国四国地方会, Oct. 2012.
5.	Motoshi Masuda, Masatake Akutagawa, Tomoki Kitawaki, Shigeru Obara, Hiroyuki Tanaka, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Takahiro Emoto, Shinsuke Konaka and Yohsuke Kinouchi : Evaluation of blood flow velocity patterns in common carotid artery using multi-branched arterial segment model of human arteries, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 257, Sep. 2012. (Summary) 総頸動脈血流速度波形と動脈弾性の関係について，1次元流体解析モデルを用いて検討している．動脈モデルはヒトの全身の主要な動脈を多枝セグメントモデルとして構築したものを用い，動脈弾性を変化させた時の総頸動脈の血流速度波形を求めた結果，動脈弾性の変化により血流速度波形が変化することを示した．これにより総頸動脈の血流速度波形を調べることにより動脈硬化を評価することができる可能性を示した．
6.	Takahiro Hirano, Motoshi Masuda, Shota Minato, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : Relationship of artery elesticity index and gender difference using carotid blood flow velocity waveforms, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 256, Sep. 2012. (Summary) 波形から自動抽出可能な動脈弾性指標の提案を目的とし，評価の妥当性を確認するため，血流速度と CAVI の測定を行い，提案した指標と CAVI の関係を調べた．また，動脈は加齢により硬化する事や，男性に比べ閉経前の女性は軟らかい事から，提案した指標と年齢の関係や性差について調べた．
7.	Shota Minato, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Hiroyuki Tanaka, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Shinsuke Konaka and Yohsuke Kinouchi : Study on automatic threshold selection of blood flow velocity extraction in carotid artery, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 255, Sep. 2012. (Summary) 頸動脈血流速度波形は動脈硬化等の循環器系の状態を反映しており，容易に測定し被測定者に提示することができれば，循環器系疾患の予防・早期発見に繋がる可能性がある．このため，小型頸動脈血流速度の測定装置を開発してきた．従来は測定者が血流速度波形抽出の為に手動でドプラ信号スペクトルの閾値を決定しなければならず，より客観的かつ，自動的な血流速度波形の抽出法の開発が望まれていた．そこで，閾値の自動選択手法について提案し，検討を行った．
8.	Kazuyoshi Kitaoka, Mitsuo Kitamura and Kazuo Yoshizaki : スポーツクライマーおよび一般成人における両腕懸垂時の血中乳酸濃度, 第67回日本体力医学会大会, Sep. 2012.
9.	Shota Minato, Motoshi Masuda, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : 頚動脈血流速度波形抽出の自動化に関する研究, 平成24年電気学会電子・情報・システム部門大会, 1104-1108, Sep. 2012. (Summary) 頸動脈血流速度波形は動脈硬化等の循環器系の状態を反映しており，容易に測定し被測定者に提示することができれば，循環器系疾患の予防・早期発見に繋がる可能性がある．このため，小型頸動脈血流速度の測定装置を開発してきた．従来は測定者が血流速度波形抽出の為に手動でドプラ信号スペクトルの閾値を決定しなければならず，より客観的かつ，自動的な血流速度波形の抽出法の開発が望まれていた．そこで，閾値の自動選択手法について提案し，検討を行った．
10.	Shun Aoi, Kazuyoshi Kitaoka, Mitsuo Kitamura, Noriyuki Shimizu and Kazuo Yoshizaki : 極低周波変動磁界の慢性暴露はマウスにおいて副腎皮質ホルモン分泌を増強させる, 第27回日本生体磁気学会大会, May 2012.
11.	Kazuyoshi Kitaoka, Mitsuo Kitamura and Kazuo Yoshizaki : スポーツクライマーおよび一般成人における両腕懸垂時の乳酸閾値, 第69回日本体力医学会中国・四国地方会, May 2012.
12.	Kazuyoshi Kitaoka, Shimizu Noriyuki, Sachiko Chikahisa, Nakagomi Madoka, Shudo Koichi, Hiroyoshi Sei and Kazuo Yoshizaki : Chronic administration of retinoic acid receptor agonist Am80 induces the ADAM10 expression in the hippocampus of SAMP8 mice, The 89th Annual Meeting of the Physiological Society of Japan, Mar. 2012.
13.	早野尚志, Mitsuo Kitamura and Kazuo Yoshizaki : 拡散測定のための生体試料測定用NMRプローブの作製と評価, Shikoku Acta Medica, Vol.67, No.5,6, 288, Dec. 2011.
14.	Motoshi Masuda, Masatake Akutagawa, Shigeru Obara, Hiroyuki Tanaka, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Takahiro Emoto, Shinsuke Konaka and Yohsuke Kinouchi : Study on blood flow velocity patterns using one-dimensional computer simulation of human arteries, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 232, Sep. 2011. (Summary) 血流速度測定システムを開発し，様々な条件で総頸動脈(CCA)血流速度測定を行ってきた．先行研究では，測定結果の波形に見られる特徴点の値から，動脈硬化などの評価の検討を行ってきたが，波形の個人差の成因について理論的に裏付けられていない．本研究では数値流体シミュレーションを用いてCCAの血流速度波形の再現を検討した．
15.	Kouki Aoyama, Motoshi Masuda, Shota Minato, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : Evaluation of atherosclerosis using carotid blood flow velocity waveforms, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 231, Sep. 2011. (Summary) 左総頸動脈における頸動脈血流速度波形は加齢の影響を強く受け，収縮期の最大速度に続いて現れる第2のピーク(S2)は動脈の硬化に伴って隆起する事が示唆されている．だが，被験者によってはS2が不明瞭であり，目視による値のばらつきも大きい．本稿では左総頸動脈血流速度波形からS2に替わり定量的・機械的に求めることができる動脈硬化の指標を提案する．そしてその指標の妥当性を確認するために，心臓足首血管指数との関連を調べた．
16.	Shota Minato, Masatake Akutagawa, Shigeru Inui, Yasushi Toyosu, Shigeru Obara, Kazuo Yoshizaki, Hiroyuki Tanaka, Kazuyoshi Kitaoka, Zhong Wang, Shinsuke Konaka, Takahiro Emoto and Yohsuke Kinouchi : Simultaneous Measurement of High Precision Body Surface Electrocardiogram and Blood Flow Velocity, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 230, Sep. 2011. (Summary) 循環器系疾患の予防・早期発見のため，先行研究で小型の血流計測装置を開発し血流動態の解明を目指してきた．さらに詳細な診断ができるように左総頸動脈の血流速度と高精度体表面心電計による心電図との同期測定を行った．
17.	Kazuyoshi Kitaoka, Hajime Miura and Kazuo Yoshizaki : 起立動作に先行する頸動脈血流速度の変動, 第19回日本運動生理学会大会, Aug. 2011.
18.	早野尚志, Mitsuo Kitamura and Kazuo Yoshizaki : 拡散測定のための生体試料測定用NMRプローブの作製と評価, 第243回徳島医学会学術集会, Jul. 2011.
19.	Asato Suzuki, Masahiro Minato, Masatake Akutagawa, Kazuo Yoshizaki, Shigeru Obara, Hiroyuki Tanaka, Yuji Hirao, Takahiro Emoto, Kazuyoshi Kitaoka, Tomoki Kitawaki, Hisao Oka and Yohsuke Kinouchi : Study on blood flow velocity patterns using one-dimensional computer simulation of human arteries, IEICE Technical Report, Vol.110, No.460, 107-111, Mar. 2011. (Summary) 数値流体シミュレーションを用いて総頸動脈血流パターンを再現し，収縮期の最大速度に続いて現れる第2のピーク(S2)が現れる現象の発生要因の特定を目指す. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572357929235968 (CiNii: 1520572357929235968)
20.	早野尚志, Mitsuo Kitamura, 浜岡建城 and Kazuo Yoshizaki : NMR検出コイルの作製と生物試料測定への応用, 第62回日本生理学会中国四国地方会, Nov. 2010.
21.	Kazuyoshi Kitaoka, Takeshi Onishi, 清水紀之, Sachiko Chikahisa, 小川眞太朗, Kazuo Yoshizaki and Hiroyoshi Sei : HSF1はマウスの睡眠調節に関与する, 第5回臨床ストレス応答学会大会, Nov. 2010.
22.	Masahiro Minato, Asato Suzuki, Hiroki Aoyama, Masatake Akutagawa, Takahiro Emoto, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : The improvement of the doppler signal decision circuit in the portable blood flow measurement system, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 206, Sep. 2010.
23.	Koki Aoyama, Shigeru Obara, Hiroyuki Tanaka, Kazuyoshi Kitaoka, Yuji Hirao, Masatake Akutagawa, Takahiro Emoto, Akihiro Inagaki, Shinsuke Konaka, Kazuo Yoshizaki and Yohsuke Kinouchi : 頚動脈血流速度パターンの折れ線近似を用いた評価, 第33回日本生体医工学会中国四国支部大会, 22, Sep. 2010.
24.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : Anticipatory changes in carotid blood flow velocity and cerebral blood flow preceds standing movement., 第87回日本生理学会大会, May 2010.
25.	Hayano Takashi and Kazuo Yoshizaki : MRS probe construction to evaluate phosphocreatine shuttle in muscle energetics., 第87回日本生理学会大会, May 2010.
26.	Toshitaka Ikehara, 西迫寛隆, 白石泰郎, Kazuyoshi Kawazoe, Kazuo Minakuchi, Mitsuo Kitamura, 庄野正行, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of time-varying magnetic field on cell volume regulation of bovine adrenal chromaffin cells in hyposmotic medium., 第87回日本生理学会大会, May 2010.
27.	Toshitaka Ikehara, Hirotaka Nishisako, Tairoh Shiraishi, Kazuyoshi Kawazoe, Kazuo Minakuchi, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of time-varying magnetic field on cell volume regulation of bovine adrenal chromaffin cells in hyposmotic medium, The Journal of Physiological Sciences, Vol.60, No.Supplement 1, S106, 2010.
28.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : Anticipatory changes in carotid blood flow velocity and cerebral blood flow precede standing movement, The Journal of Physiological Sciences, Vol.60, No.Supplement 1, S92, 2010.
29.	Takashi Hayano and Kazuo Yoshizaki : MRS probe construction to evalute phosphocreatine shuttle in muscle energetics, The Journal of Physiological Sciences, Vol.60, No.Supplement 1, S24, 2010.
30.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Akihiro Inagaki, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : 起立動作時における予測的な脳血流量，総頸動脈血流速度の変化, Journal of Physiological Society of Japan, Vol.72, No.4, 126-127, 2010.
31.	Kazuo Yoshizaki, Hayano Takashi, Mitsuo Kitamura and Arizono Naoki : Histamine and exocytosis in mast cells studied with 1H-NMR, 生物物理第47回年会講演予稿集, Vol.49, S56, Oct. 2009.
32.	Masahiro Minato, Asato Suzuki, Yoshiki Utunomiya, Masatake Akutagawa, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Hiroyuki Tanaka and Yohsuke Kinouchi : Measurement of the Carotid Blood Flow Velocity during Bicycle Exercise, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 226, Sep. 2009.
33.	Yoshiki Utunomiya, Masahiro Minato, Asato Suzuki, Takahiro Emoto, Masatake Akutagawa, Hiroyuki Tanaka, Shigeru Obara, Kazuo Yoshizaki and Yohsuke Kinouchi : Change of heart rate and peak systolic blood flow velocity in common carotid artery during Head-up Tilt using power spectral analysis, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 225, Sep. 2009.
34.	宇都宮芳希, Azhim Azran, 秋岡響平, 鈴木安里, Masatake Akutagawa, Hiroyuki Tanaka, Shigeru Obara, Kazuo Yoshizaki and Yohsuke Kinouchi : Evaluation of blood flow velocity variability in common carotid artery using power spectral analysis, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 246, Sep. 2008.
35.	鈴木安里, 篠原康一, Azhim Azran, 秋岡響平, 宇都宮芳希, Masatake Akutagawa, 平尾友二, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka and Yohsuke Kinouchi : A Study on Measurement of the Carotid Blood Flow Velocity during Bicycle Exercise, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 245, Sep. 2008.
36.	秋岡響平, Azhim Azran, 宇都宮芳希, Masatake Akutagawa, 平尾友二, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka and Yohsuke Kinouchi : The development of the portable Blood Flow Measurement System, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 244, Sep. 2008.
37.	早野尚志 and Kazuo Yoshizaki : 31P-NMRによる分子情報の活用, 第237回徳島医学会学術集会, Aug. 2008.
38.	Azhim Azran, Hiroyuki Tanaka, Shigeru Obara, Kazuo Yoshizaki and Yohsuke Kinouchi : 血流速度波形を用いた心臓自律神経系活動の評価の検討, Japanese Journal of Physical Fitness and Sports Medicine, Vol.57, No.4, 521, 2008.
39.	早野尚志, Mitsuo Kitamura, 浜岡建城 and Kazuo Yoshizaki : 1H-NMRによる拡散画像測定法の開発, Journal of Physiological Society of Japan, Vol.70, No.2, 66, 2008.
40.	篠原康一, Azhim Azran, 秋岡響平, Masatake Akutagawa, 平尾友二, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Blood flow velocity pattern of carotid artery for people doing regular physical training, 第30回日本生体医工学会中四国支部大会講演抄録, 9, Oct. 2007. (Keyword) blood flow velocity / physical training / ultrasound Doppler method
41.	山本紗世, Azhim Azran, 篠原康一, 秋岡響平, Masatake Akutagawa, 平尾友二, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Measurement of blood flow velocity in the carotid artery for head movements, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 239, Sep. 2007.
42.	秋岡響平, Azhim Azran, 篠原康一, Masatake Akutagawa, 平尾友二, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Effect of Gender and body size on Blood Flow Velocities and Blood Pressure, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 238, Sep. 2007.
43.	篠原康一, Azhim Azran, 秋岡響平, Masatake Akutagawa, 平尾友二, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : Blood flow velocity waveformas of the carotid artery for people doing regular physical training and without regular physical training, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 237, Sep. 2007.
44.	神高宏明, Toshitaka Ikehara, Hisao Yamaguchi, Akihiro Inagaki, Kazuo Yoshizaki and Yohsuke Kinouchi : Effects of a Time-Varying Magnetic Field on Transient Increase in Intracellular Ca²⁺ in Cultured Chromaffin Cells, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 223, Sep. 2007.
45.	植松英二 and Kazuo Yoshizaki : 人体における尿への酸排泄の計測, Journal of Physiological Society of Japan, Vol.69, No.3, 125, Mar. 2007.
46.	Azhim Azran, Hisao Yamaguchi, Masatake Akutagawa, Toshitaka Ikehara, Noboru Utsuyama, Kazuo Yoshizaki, Hiroyuki Tanaka and Yohsuke Kinouchi : Simultaneous measurement of the maximum blood flow velocity in common carotid, branchial and femoral arteries during head-up-tilt by Doppler ultrasound method, The 84th Annual Meeting of the Physiological Society of Japan, Mar. 2007.
47.	Hiroyuki Tanaka, Hisao Yamaguchi, Azhim Azran, Yohsuke Kinouchi, Yuji Hirao, Shigeru Obara, Kazuo Yoshizaki, Toshitaka Ikehara, 宇都山登 and Hiroshi Miyamoto : 頸動脈血流速度計測システムの改良と波形情報について, Japanese Journal of Physical Fitness and Sports Medicine, Vol.56, No.6, 639, 2007.
48.	Hiroyuki Tanaka, Hisao Yamaguchi, Shigeru Obara, Azhim Azran, Yohsuke Kinouchi, Yuji Hirao, Kazuo Yoshizaki, Toshitaka Ikehara, 宇都山登 and Hiroshi Miyamoto : 頸動脈血流速度波形情報, Japanese Journal of Physical Fitness and Sports Medicine, Vol.56, No.5, 545, 2007.
49.	Hiroyuki Tanaka, Hisao Yamaguchi, Shigeru Obara, Azhim Azran, Yohsuke Kinouchi, Yuji Hirao, Kazuo Yoshizaki, Toshitaka Ikehara, 宇都山登 and Hiroshi Miyamoto : 頸動脈血流速度波形解析, Japanese Journal of Physical Fitness and Sports Medicine, Vol.56, No.2, 296, 2007.
50.	Hiroyuki Tanaka, Hisao Yamaguchi, Shigeru Obara, Azhim Azran, Mizuki Katai, Tatsuaki Kamiya, Yuji Hirao, Yohsuke Kinouchi, Kazuo Yoshizaki, Toshitaka Ikehara, 宇都山登 and Hiroshi Miyamoto : 頸動脈血流速度波形解析, 第58回日本生体医工学会中・四国地方会, Nov. 2006.
51.	南有紀, 塩田直青子, Toshitaka Ikehara, 庄野正行, Keisuke Ishizawa, Kazuo Yoshizaki, Yohsuke Kinouchi, Shinji Abe, Hitoshi Houchi, Kazuyoshi Kawazoe and Kazuo Minakuchi : ウシ副腎髄質細胞の容積変化に及ぼす変動磁界の影響, 第45回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 76, Oct. 2006.
52.	Azhim Azran, Shinohara Kohichi, Katai Mizuki, Kamiya Tatsuaki, Yuji Hirao, Hisao Yamaguchi, Kazuo Yoshizaki, Masahiro Nomura, Hiroyuki Tanaka, Shigeru Obara and Yohsuke Kinouchi : The Effect of Aerobic Exercise on Blood Flow Velocity and Autonomic Activity, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 3258, Sep. 2006.
53.	篠原康一, Azhim Azran, Katai Mizuki, Kamiya Tatsuaki, Yuji Hirao, Kazuo Yoshizaki, Shigeru Obara, Masahiro Nomura, Hiroyuki Tanaka, Hisao Yamaguchi and Yohsuke Kinouchi : 高血圧症患者と健常者の血流速度パターンの解析, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 194, Sep. 2006.
54.	Mizuki Katai, Azhim Azran, Tatsuaki Kamiya, Koichi Shinohara, Yuji Hirao, Hisao Yamaguchi, Kazuo Yoshizaki, Masahiro Nomura, Shigeru Obara, Hiroyuki Tanaka and Yohsuke Kinouchi : 加齢による頚動脈血流速度の変化, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 193, Sep. 2006.
55.	Tatsuaki Kamiya, Azhim Azran, Mizuki Katai, Masatake Akutagawa, Hisao Yamaguchi, Hiroyuki Tanaka, Masahiro Nomura, Shigeru Obara, Kazuo Yoshizaki, Yuji Hirao and Yohsuke Kinouchi : 運動中の頸動脈血流測定による血液循環システム変化の検出, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 192, Sep. 2006.
56.	Hiroyuki Tanaka, Hisao Yamaguchi, Shigeru Obara, Azhim Azran, Yohsuke Kinouchi, Yuji Hirao, Kazuo Yoshizaki, Toshitaka Ikehara, 宇都山登 and Hiroshi Miyamoto : 頸動脈血流速度計測システムの改良と波形解析について, 第61回日本体力医学会大会, Vol.55, No.6, 649, Sep. 2006. (Keyword) 超音波ドプラ / 頸動脈血流速度 / 血流速度波形
57.	Hiroyuki Tanaka, Hisao Yamaguchi, Shigeru Obara, Azhim Azran, Yohsuke Kinouchi, Yuji Hirao, Kazuo Yoshizaki, Toshitaka Ikehara, Noboru Utsuyama and Hiroshi Miyamoto : Waveform analysis of the blood flow velocity in the common carotid artery measured by the Doppler ultrasound method., 体力科学第57回日本体力医学会中国・四国地方会, Vol.55, No.5, 536, Jun. 2006. (Keyword) 連続波超音波ドプラ法 / 頸動脈血流速度波形 / 波形パターン
58.	Hisao Yamaguchi, Keiko Hosokawa, Toshitaka Ikehara, Hiroe Shichijo, Mitsuo Kitamura, Kazuo Yoshizaki, Yohsuke Kinouchi, Hiroshi Miyamoto and Katsuo Aizawa : Effects of ELF differetiation of cultured osteoblast-like cells, The Journal of Physiological Sciences, Vol.56, S111, Mar. 2006. (Keyword) osteoblast
59.	Toshitaka Ikehara, Hiromi Sasaki, Yuki Minami, Keiko Hosokawa, Hisao Yamaguchi, Mitsuo Kitamura, Masayuki Shono, Kazuyoshi Kawazoe, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of a time-varying magnetic field on intracellular organells of bovine adrenal chronmaffin cells in culture, The Journal of Physiological Sciences, Vol.56, S110, Mar. 2006. (Keyword) intracellular Ca2+ / acetylcholine / time-varying magnetic field / organells
60.	Hiroyuki Tanaka, Hisao Yamaguchi, Azhim Azran, Yohsuke Kinouchi, Yuji Hirao, Kazuo Yoshizaki, Toshitaka Ikehara, Noboru Utsuyama and Hiroshi Miyamoto : Waveform analysis of the blood flow velocity in the common carotid artery measured by the Doppler ultrasound method., 体力科学第56回日本体力医学会中国・四国地方会, Vol.55, No.1, 188, Nov. 2005. (Keyword) 連続波超音波ドプラ法 / 頸動脈血流速度波形 / 心血管系障害
61.	Hiromi Sasaki, 南有紀, Toshitaka Ikehara, 細川敬子, Hisao Yamaguchi, Kazuo Yoshizaki, Yohsuke Kinouchi, Keisuke Ishizawa, Kazuyoshi Kawazoe, Hitoshi Houchi and Kazuo Minakuchi : 牛副腎髄質由来細胞内の一過性Ca²⁺増加機構に対する磁界の影響, 第44回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 126, Nov. 2005.
62.	Azhim Azran, Jun Yamaguchi, Mizuki Katai, Tatsuaki Kamiya, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi, Kazuo Yoshizaki, Susumu Ito and Masahiro Nomura : Telemetry system for measuring doppler blood flow during physical exercises, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 385, Sep. 2005.
63.	Kamiya Tatsuaki, Masatake Akutagawa, Yohsuke Kinouchi, Hisao Yamaguchi, Kazuo Yoshizaki, Yuji Hirao, Azhim Azran, Yamaguchi Jun and Katai Mizuki : Blood flow system identification in position of rest, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 247, Sep. 2005.
64.	Yamaguchi Jun, Azhim Azran, Yuji Hirao, Masatake Akutagawa, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : Analysis for sound-field of new-type transduceres, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 246, Sep. 2005.
65.	Katai Mizuki, Azhim Azran, Yamaguchi Jun, Kamiya Tatsuaki, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi, Kazuo Yoshizaki, Masahiro Nomura and Susumu Ito : 心疾患患者における頸動脈血流計測と解析, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 245, Sep. 2005.
66.	Kadowaki Naohiro, Uchigami Yusuke, Toshitaka Ikehara, Keiko Hosokawa, Hisao Yamaguchi, Hitoshi Houchi, Kazuo Yoshizaki, Hiroshi Miyamoto and Yohsuke Kinouchi : Effects of strong time-varying magnetic fields on increasing intracalcium concentration of HeLa cell, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 229, Sep. 2005.
67.	Uchigami Yusuke, Kadowaki Naohiro, Toshitaka Ikehara, Hitoshi Houchi, Kazuo Yoshizaki, Hiroshi Miyamoto and Yohsuke Kinouchi : Effects of time-varing magnetic fields on regulation of intracellular Ca²⁺ in cultured Bovine Adrenal Chromaffine cells, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 228, Sep. 2005.
68.	Shichijo Hiroe, Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Kazuo Yoshizaki, Aizawa Katsuo and Yohsuke Kinouchi : Effects of ELF-MF on signaling mechanism of osteoblast-like cells, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 227, Sep. 2005.
69.	Hiromi Sasaki, Tadahiro Teramoto, Toshitaka Ikehara, Hisao Yamaguchi, Keiko Hosokawa, Hitoshi Houchi, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects on intracellular signal transduction of adrenal chromaffin cells of exposure to a switched 1.5 T magnetic field, 日本生体磁気学会雑誌, Vol.18, No.1, 158, Jul. 2005.
70.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Yui Shichijo, Mitsuo Kitamura, Kazuo Yoshizaki, Yohsuke Kinouchi, Hiroshi Miyamoto and Katsuo Aizawa : Effects of ELF magnetic fields on signal transduction for the differentiation of osteoblast-like cells, The Japanese Journal of Physiology, May 2005.
71.	Toshitaka Ikehara, Hiromi Sasaki, Tadahiro Teramoto, Keiko Hosokawa, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki, Yohsuke Kinouchi, Hisao Yamaguchi and Hiroshi Miyamoto : Effects of a time-varying magnetic field on transient increase in intracellular Ca²⁺ concentration of bovine adrenal chromaffin cells, The Japanese Journal of Physiology, May 2005.
72.	Yohsuke Kinouchi, Toshitaka Ikehara, Hisao Yamaguchi, Keiko Hosokawa, Hitoshi Houchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of time-varying strong magnetic field on cellular functions, 第44回日本生体医工学大会, Vol.43, No.1, 159, Apr. 2005.
73.	Hiroyuki Tanaka, Hisao Yamaguchi, Toshitaka Ikehara, Noboru Utsunomiya, Kazuo Yoshizaki, Yuji Hirao, Azhim Azran, Yohsuke Kinouchi and Hiroshi Miyamoto : 超音波ドプラ血流速度測定装置改良のための音場実測装置の試作とその計測例, 第54回日本体力医学会中国·四国地方会, Dec. 2004.
74.	Toshitaka Ikehara, Tadahiro Eramoto, Hiromi Sasaki, Hisao Yamaguchi, Keiko Hosokawa, Mitsuo Kitamura, Masayuki Shono, Hitoshi Houchi, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effect of time-varying strong magnetic field on transient increase in intracellular Ca2+ in bovine adrenal chromaffin cells, 第8回シンポジウムおよび特定領域研究「強磁場新機能」第2回シンポジウム, Sep. 2004. (Keyword) trong magnetic / intracellular Ca2+ / bovine adrenal chromaffin cells
75.	Kadowaki Naohiro, Uchigami Yusuke, Yohsuke Kinouchi, Kazuo Yoshizaki, Toshitaka Ikehara, Keiko Hosokawa, Tadahiro Teramoto and Hisao Yamaguchi : 変動強磁界によるHela細胞の影響, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, Sep. 2004.
76.	Shichijo Hiroe, Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Mitsuo Kitamura, Shono Masayuki, Kazuo Yoshizaki, Yohsuke Kinouchi, Hiroshi Miyamoto and Aizawa Katsuo : 培養骨芽細胞に及ぼすELF変動磁界の影響, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, Sep. 2004.
77.	Uchigami Yusuke, Kadowaki Naohiro, Yohsuke Kinouchi, Kazuo Yoshizaki, Toshitaka Ikehara, Keiko Hosokawa, Tadahiro Teramoto and Hisao Yamaguchi : 変動強磁界曝露によるミトコンドリアへの影響, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, Sep. 2004.
78.	Azhim Azran, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : Tiltテストを用いた非自発的姿勢変化に伴う最大血流速度の変化, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, Sep. 2004.
79.	Yamaguchi Jun, Azhim Azran, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : リニアアレイトランスデューサの設計シミュレーション, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, Sep. 2004.
80.	Hiroyuki Tanaka, Hisao Yamaguchi, Toshitaka Ikehara, Noboru Utsunomiya, Kazuo Yoshizaki, Yuji Hirao, Yukihiro Hayashi, Katsuyoshi Kadan, Azhim Azran, Yohsuke Kinouchi and Hiroshi Miyamoto : 音場実測装置の試作による超音波ドプラ血流速度測定装置の改良とその応用, 第59回日本体力医学会, Sep. 2004.
81.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, 七条裕衣, Mitsuo Kitamura, Kazuo Yoshizaki, Yohsuke Kinouchi, Hiroshi Miyamoto and 會沢勝夫 : Imspector法による培養骨芽細胞の分化に及ぼすELF磁界の影響, 第81回日本生理学会大会, Jun. 2004.
82.	Toshitaka Ikehara, Tadahiro Teramoto, Hitoshi Houchi, Hisao Yamaguchi, Keiko Hosokawa, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 培養牛副腎髄質由来細胞の情報伝達機構に及ぼす変動磁界の影響, 第81回日本生理学会大会, Jun. 2004.
83.	Hisao Yamaguchi, Hiroyuki Tanaka, Toshitaka Ikehara, Keiko Hosokawa, Yuji Hirao, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 試作の超音波ドプラ血流速度計測装置による漸増漸減運動負荷時の血流動態, Journal of Physiological Society of Japan, Vol.66, No.2, 69, 2004.
84.	Toshitaka Ikehara, Ki Ho Park, Hitoshi Houchi, Hisao Yamaguchi, Keiko Hosokawa, Mitsuo Kitamura, Masayuki Shono, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Tesla変動強磁界が牛副腎髄質クロマフィン細胞に及ぼす影響., 第18回日本生体磁気学会発表, 2003. (Keyword) 変動強磁界 / 牛副腎髄質クロマフィン細胞
85.	Azhim Azran, 林幸宏, 黒田隆, 西田将司, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : 運動に伴う最大血流速度の変化, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, Oct. 2003.
86.	Hisao Yamaguchi, 中野芳子, Keiko Hosokawa, Toshitaka Ikehara, Mitsuo Kitamura, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects of ELF magnetic fields on differentiation of cultured osteoblasts like cells., The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.16, No.1, 82-83, May 2003.
87.	Toshitaka Ikehara, Ki Ho Park, Hitoshi Houchi, Hisao Yamaguchi, Keiko Hosokawa, Mitsuo Kitamura, Masayuki Shono, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : Effects on bovine adrenal chromaffin cells to a switched 1.5Tesla magnetic field, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.16, No.1, 80-81, May 2003.
88.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, 中野芳子, Mitsuo Kitamura, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : 骨芽細胞の増殖と分化に及ぼすELF磁界の影響, 第80回日本生理学会大会, Mar. 2003.
89.	Toshitaka Ikehara, Ki Ho Park, Hitoshi Houchi, Keiko Hosokawa, Hisao Yamaguchi, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 副腎髄質由来細胞におよぼす1.5Tesla変動強磁界の影響, 第80回日本生理学会大会, Mar. 2003.
90.	Toshitaka Ikehara, 村戸良平, Ki Ho Park, Hitoshi Houchi, Hisao Yamaguchi, Keiko Hosokawa, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 副腎髄質由来細胞の細胞内情報伝達機構に及ぼす変動磁界の影響, 第79回日本生理学会大会, Mar. 2002.
91.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, 中野芳子, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 培養骨芽細胞の分化機構に及ぼすELF磁界の影響, 第79回日本生理学会大会, Mar. 2002.
92.	Keiko Hosokawa, 中野芳子, Hisao Yamaguchi, Toshitaka Ikehara, Mitsuo Kitamura, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : ELF 変動磁界が培養骨芽細胞の分化誘導に及ぼす影響, Journal of Physiological Society of Japan, Vol.64, No.12, 295, 2002.
93.	Toshitaka Ikehara, 村戸良平, Ki Ho Park, Hitoshi Houchi, Hisao Yamaguchi, Keiko Hosokawa, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 牛副腎髄質クロマフィン細胞のCa2+ 動態に及ぼす変動磁界の影響, Journal of Physiological Society of Japan, Vol.64, No.4, 90, 2002.
94.	中野芳子, Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Mitsuo Kitamura, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 培養骨芽細胞の分化誘導に及ぼすELF 変動磁界の影響, 日本生理学会雑誌, Vol.64, No.4, 90, 2002.
95.	Toshitaka Ikehara, Ki Ho Park, 村戸良平, Keiko Hosokawa, Hisao Yamaguchi, Hitoshi Houchi, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : 副腎髄質由来細胞に及ぼす変動磁界の影響, 第78回日本生理学会大会, Mar. 2001.
96.	會沢勝夫, Toshitaka Ikehara, Hisao Yamaguchi, Keiko Hosokawa, Kazuo Yoshizaki and Hiroshi Miyamoto : K+脱分極に伴う細胞膜構成脂肪酸のC-H振動の変動について, 第78回日本生理学会大会, Mar. 2001.
97.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : 培養骨芽細胞の分化発現に及ぼすELF磁界の影響, 第78回日本生理学会大会, Mar. 2001.
98.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Mitsuo Kitamura, Kazuo Yoshizaki and Hiroshi Miyamoto : 骨芽細胞の増殖と分化に及ぼすELF磁界の影響, 日本生理学会雑誌, Vol.63, No.4, 137, 2001.
99.	樫本英樹, Ki Ho Park, 細川敬子, Toshitaka Ikehara, Yohsuke Kinouchi, 山口久雄, Kazuo Yoshizaki and Hiroshi Miyamoto : 骨芽細胞の細胞内カルシウムイオン濃度に及ぼすELF磁界の効果, 第22回日本エム・イー学会中国四国支部大会抄録集, 33, Nov. 1999.
100.	會沢勝夫, Toshitaka Ikehara, Hisao Yamaguchi, Keiko Hosokawa, Kazuo Yoshizaki and Hiroshi Miyamoto : K+脱分極による細胞膜表面構造の動態, 第76回日本生理学会大会, Mar. 1999.
101.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : 骨芽細胞の細胞内情報伝達機構へのELF磁界の影響, Chemical Record, Mar. 1999.
102.	Toshitaka Ikehara, Ki Ho Park, Keiko Hosokawa, Hisao Yamaguchi, Hitoshi Houchi, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 副腎髄質細胞の細胞内Ca2+濃度増加機構に及ぼす変動強磁界の影響, 第76回日本生理学会大会, Mar. 1999.
103.	Toshitaka Ikehara, Hitoshi Houchi, Hisao Yamaguchi, Keiko Hosokawa, Ki Ho Park, Yohsuke Kinouchi, Kazuo Yoshizaki and Hiroshi Miyamoto : 副腎クロマフィン細胞に及ぼす変動強磁界の影響, 第75回日本生理学会大会, Mar. 1998.
104.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Kazuo Yoshizaki and Hiroshi Miyamoto : HeLa細胞の細胞周期調節蛋白の発現量と細胞内Kイオンの役割, 第75回日本生理学会大会, Mar. 1998.
105.	會沢勝夫, Toshitaka Ikehara, Hisao Yamaguchi, Keiko Hosokawa, Kazuo Yoshizaki and Hiroshi Miyamoto : 細胞膜表在性蛋白質構造に対する変動磁界及び水素イオン濃度の影響, 第75回日本生理学会大会, Mar. 1998.
106.	Toshitaka Ikehara, Ki Ho Park, 會沢勝夫, Hisao Yamaguchi, Keiko Hosokawa, Kazuo Yoshizaki, Hiroshi Miyamoto and Yohsuke Kinouchi : 培養HeLa細胞のCa2+依存性K+チャネルが変動強磁界より受ける影響, 第74回日本生理学会大会, Mar. 1997.
107.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Akira Takahashi and Kazuo Yoshizaki : 低K+条件下での細胞周期調節因子の発現量とその局在, 第74回日本生理学会大会, Mar. 1997.
108.	Toshitaka Ikehara, Hisao Yamaguchi, Keiko Hosokawa, Akira Takahashi, Hiroshi Miyamoto and Kazuo Yoshizaki : HeLa細胞の利尿剤感受性K+排出とRb+取込みに及ぼす細胞内外イオンの影響, 第73回日本生理学会大会, Apr. 1996.
109.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Akira Takahashi, Kazuo Yoshizaki and Hiroshi Miyamoto : 同調した細胞の細胞周期調節蛋白の発現とKイオンの役割, 第73回日本生理学会大会, Apr. 1996.
110.	Kazuo Yoshizaki, Toshitaka Ikehara and 早野尚志 : マスト細胞からのヒスタミン遊離機序の1H-NMRによる研究, 第73回日本生理学会大会, Apr. 1996.
111.	Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Akira Takahashi and Kazuo Yoshizaki : 低K+条件下におけるHeLa細胞の細胞周期調節因子の発現, 第72回日本生理学会大会, Mar. 1995.
112.	Toshitaka Ikehara, Hisao Yamaguchi, Keiko Hosokawa, Akira Takahashi, Kazuo Yoshizaki and Hiroshi Miyamoto : 培養HeLa細胞における利尿剤感受性外向きと内向きK+輸送, 第72回日本生理学会大会, Mar. 1995.
113.	Kazuo Yoshizaki, Toshitaka Ikehara and 早野尚志 : マスト細胞の顆粒に結合したヒスタミンの1H-NMR法による研究, 第72回日本生理学会大会, Mar. 1995.
114.	Kazuo Yoshizaki, 早野尚志 and 亘弘 : ラクテート・オキシダーゼによる乳酸の1H-NMR共鳴線の同定, 第71回日本生理学会大会, Mar. 1994.

Et cetera, Workshop:

1.	Arisa Tada, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Yohsuke Kinouchi and Shinsuke Konaka : Comparison of the arterial elasticity evaluation based on the carotid blood flow velocity and CAVI, IEICE Technical Report (MBE), Vol.115, No.147, 19-22, Jul. 2015. (Summary) 近年，日本国内における死亡原因の約25%は脳梗塞や心筋梗塞など循環器系疾患であることが厚生労働省より報告されている．家庭における動脈弾性の定期的な診断が実現すれば，生活習慣の改善につながり，動脈硬化の進行を抑制が期待できる．頸動脈血流速度波形では，動脈弾性の指標となりうることが期待されている．そこで，動脈硬化の指標であるCAVIと比較することにより，頸動脈血流速度波形を用いた指標の妥当性を調査した．被験者は弾性134名，女性116名の計250名で，血流速度測定した後，CAVIを測定した．結果，S1やS2/S1，FAIとCAVIに相関があり(r>0.58)，動脈弾性の指標となることを示唆した． (Keyword) blood flow velocity / carotid artery / artery elasticity / CAVI (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520853833178490752 (CiNii: 1520853833178490752)
2.	Kazuyoshi Kitaoka, Shun Aoi, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : 起立に先行する頸動脈血流の変化と血圧との関連, 第63回生理学会中国四国地方会, Oct. 2011.
3.	Kouki Aoyama, Masatake Akutagawa, Takahiro Emoto, Shigeru Obara, Kazuo Yoshizaki, Kazuyoshi Kitaoka, Hiroyuki Tanaka, Shinsuke Konaka and Yohsuke Kinouchi : Evaluation of atherosclerosis using carotid blood flow velocity waveforms, --- Feature extraction of systolic ---, 電子情報通信学会技術研究報告，MEとバイオサイバネティックス研究会, Vol.111, No.121, 41-46, Jul. 2011. (Summary) 左総頸動脈血流速度波形にて，収縮期の最大速度(S1)に続いて現れる第2のピーク(S2)は，動脈硬化の指標となり得ることが示唆されている．だが被験者によってはS2が不明瞭であり，目視による値のばらつきが大きい．そこで，S2に替わり血液速度波形から機械的に求めることができる指標A<sub>HR</sub>， A<sub>SII</sub> (S1以降収縮期面積)を提案する．そして血庄と脈波伝播速度から求められる動脈硬化の指標のCAVI (心臓足首血管指数)との関連からパラメータの妥当性を確認した．その結果A<sub>HR</sub>がCAVIと最も強い相関(r=0.765)があり，動脈硬化の指標として妥当であると確認できた． (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520853832837782656 (CiNii: 1520853832837782656)
4.	Kazuyoshi Kitaoka, Shun Aoi, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : 起立に伴う予測的頸動脈血流速度変化の検討-血流速度と血圧の同時記録による解析-, 第67回日本体力医学会中国・四国地方会大会, May 2011.
5.	Kazuyoshi Kitaoka, Hajime Miura, Mitsuo Kitamura, Masatake Akutagawa, Yohsuke Kinouchi and Kazuo Yoshizaki : 起立に先行する総頸動脈血流速度の予測的変化, 第66回日本体力医学会中国・四国地方会大会, Nov. 2010.
6.	早野尚志, Mitsuo Kitamura and Kazuo Yoshizaki : 1H-NMRスペクトルによるマスト細胞のヒスタミン分泌の解析, Shikoku Acta Medica, Vol.65, No.5,6, 206, Dec. 2009.
7.	早野尚志, Mitsuo Kitamura, 浜岡建城 and Kazuo Yoshizaki : 1H-MRI顕微画像測定法の基礎的検討, Shikoku Acta Medica, Vol.63, No.5,6, 252-253, Dec. 2007.
8.	植松英二, 金川俊哉 and Kazuo Yoshizaki : 尿への酸排泄の日内変動, Shikoku Acta Medica, Vol.62, No.5,6, 269, Dec. 2006.
9.	Kadowaki Naohiro, Uchigami Yusuke, Toshitaka Ikehara, Keiko Hosokawa, Hisao Yamaguchi, Hitoshi Houchi, Kazuo Yoshizaki, Hiroshi Miyamoto and Yohsuke Kinouchi : Effects of Strong Time-Varying Magnetic Fields of Increasing Intracalcium Concentration of Cultured Cells, IEICE Technical Report, Vol.105, No.222, 33-36, Jul. 2005.
10.	Shichijo Hiroe, Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Kazuo Yoshizaki, Aizawa Katsuo and Yohsuke Kinouchi : 骨芽細胞の情報伝達機構に及ぼすELF磁界の影響, IEICE Technical Report, Vol.105, No.222, 29-32, Jul. 2005.
11.	Azhim Azran, Yamaguchi Jun, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi, Kazuo Yoshizaki, Susumu Ito and Masahiro Nomura : Simultaneous Measurement of Blood Flow Velocity and ECG for Cardiovascular Disease in Elder Subjects, IEICE Technical Report, Vol.105, No.222, 1-4, Jul. 2005.
12.	Mitsuo Kitamura, Akihiro Inagaki and Kazuo Yoshizaki : 生体試料測定のためのNMR装置特性の基礎的検討, Shikoku Acta Medica, Vol.61, No.1,2, 60, Apr. 2005.
13.	Azhim Azran, Yuji Hirao, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : A change of maximum blood flow velocity in the human arteries during involuntarypostural changes, IEICE Technical Report, Vol.104, No.401, 5-8, Nov. 2004.
14.	Yusuke Uchigami, Toshitaka Ikehara, Tadahiro Teramoto, Keiko Hosokawa, Hisao Yamaguchi, Hitoshi Houchi, Kazuo Yoshizaki, Yohsuke Kinouchi and Hiroshi Miyamoto : Effects of a time-varying strong magnetic field on changes in intracellular Ca²⁺ concentration in chromaffin cells derived from adrenal medulla, IEICE Technical Report, Vol.104, No.179, 53-56, Jul. 2004.
15.	Hiroe Shichijo, Keiko Hosokawa, Hisao Yamaguchi, Toshitaka Ikehara, Mitsuo Kitamura, Masayuki Shono, Kazuo Yoshizaki, Yohsuke Kinouchi, Hiroshi Miyamoto and Katsuo Aizawa : Effects of ELF Magnetic Fields on Cultured Osteoblast Cells by ImSpector System, IEICE Technical Report, Vol.104, No.179, 49-52, Jul. 2004. (Summary) It is reported that the magnetic field exposure is for fracture healing of the intractable, and it is shown experimentally that the biofunction in which the calcium ion is concerned is affected. In this study, the effects of sine wave alternating current magnetic field in the ELF region on the osteoblast was probed using the spectral diffraction image microscope system, and the basic action mechanism was examined. Using insulin-like growth factor (IGF-1) which is the factor shoulders the important role for growth and differentiation of the cells, the difference between the effect by exposure was examined with these drug effects to the osteoblasts. The effect which the cell receives in cencer and periferal regions of the Schale in which the induced current density differs was compared in order to examine the effect of the induced current which arises in the Shale by fluctuation magnetic fields.
16.	Yuji Hirao, Dali Zhang, Kengo Tmukai, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : Measurements of Maximum Blood Flow Velocities and The Propagation Time of Velocity Pulse Waves on Carotid,Brachial and Femoral Arteries during Exercise by an Ultrasonic Doppler Method, IEICE Technical Report, Vol.MBE-99, No.55, 1-6, Jul. 1999.
17.	Yuji Hirao, Dali Zhang, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : Synchronized Measurements of Blood Flow Distribution at Different Points of the Human Body by the Ultrasonic Doppler Method, IEICE Technical Report, Vol.MBE-98, No.63, 149-155, Jul. 1998.
18.	Aiwu Pan, Jufang He, Tetsuya Ozaki, Yohsuke Kinouchi, Hisao Yamaguchi and Kazuo Yoshizaki : Analysis of the Power Spectral Distribution of CW Ultrasonic Doppler Signal, IEICE Technical Report, Vol.MBE96-53, 57-64, Jul. 1996.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

A study of functional MRI on whole brain measured by EPI sequence (Project/Area Number: 07557069 )
^1H-NMR Analysis on Histamine Release Mechanism in Mast Cells. (Project/Area Number: 06670054 )
クレアチンリン酸エネルギー・シャトル説の^<31>P-NMR法による検討 (Project/Area Number: 63617510 )
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Professor Emeritus : Yoshizaki, Kazuo

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)