Tokushima University / Educator and Researcher Directory --- Morimoto, Tadaoki

Field of Study

○	Surgery, 乳腺外科, 内分泌外科学

Subject of Study

○	乳癌の局所進展からみた乳房温存療法に関する研究, 乳癌検診システム確立の研究に関する研究, 生体の電気特性に関する研究 (breast cancer, 局所進展, 乳房温存療法, 早期発見·診断, 腫瘍の電気特性)

Book / Paper

Book:

1.	Tadaoki Morimoto : マンモグラフィ検診精度管理中央委員会とその役割, Nagai Shoten Co., Osaka, Apr. 2006.
2.	Tadaoki Morimoto and 武藤芳照 : 乳ガン術後のリハビリテーションのための水中運動の仕方と注意は?, Japan Medkal Journal, Tokyo, Mar. 2006.
3.	Tadaoki Morimoto : 乳ガン術後のリハビリテーションのための水中運動の仕方と注意は?, Japan Medkal Journal, Tokyo, Mar. 2006.
4.	岡崎邦泰, Tadaoki Morimoto and 武籐芳照 : 乳癌治療をめぐる運動・生活ガイド, Japan Medkal Journal, Tokyo, Mar. 2006.
5.	Tadaoki Morimoto and 田中隆 : ワンポイントアドバイス:下胸筋神経·血管温存, 文光堂, Tokyo, Nov. 2005.
6.	Tadaoki Morimoto, 田中隆, 広瀬千恵子 and 生島葉子 : 乳癌検診にすぐに役立つマンモグラム·アトラス改訂第2版, Nagai Shoten Co., Osaka, Sep. 2005.
7.	Tadaoki Morimoto : 良性乳腺疾患アトラス-乳腺診療の手引き-, Nagai Shoten Co., Osaka, May 2005.
8.	Tadaoki Morimoto : 乳腺腫瘤の診察手順, IGAKU-SHOIN Ltd.Tokyo,Japan, Tokyo, Jan. 2005.
9.	Tadaoki Morimoto and その他 19名 : マンモグラフィによる乳がん検診の手引き精度管理マニュアル第3版, Japan Medkal Journal, Aug. 2004.
10.	Tadaoki Morimoto : 乳癌診断のコツと落とし穴, Nakayama-Shoten Co., Ltd., Tokyo, Jun. 2004.
11.	Tadaoki Morimoto : 乳癌診療二頁の秘訣, KANEHARA & CO., LTD., Tokyo, May 2004.
12.	Tadaoki Morimoto, 田中隆, 広瀬千恵子 and 生島葉子 : 乳癌検診にすぐに役立つマンモグラフィ·アトラス, Nagai Shoten Co., Tokyo, Jun. 2003.
13.	大内憲明, 飯沼武, 今村恵子, 遠藤登喜子, 大貫幸二, 小田切邦雄, 鈴木総長, 館野之男, 辻一郎, 角田博子, 寺田央, 東野恵利子, 永井宏, 東田善治, 福田護, 掘田勝平, 松本満臣, Tadaoki Morimoto and 横江隆夫 : マンモグラフイによる乳がん検診の手引き, Japan Medkal Journal, Tokyo, Jun. 2001.
14.	岡崎邦泰, Tadaoki Morimoto and 武籐芳照 : 乳がん術後の運動·生活ガイド, Japan Medkal Journal, Tokyo, Apr. 2001.
15.	Tadaoki Morimoto and 笹三徳 : 改訂第3版運動療法ガイド正しい運動処方を求めて, Japan Medkal Journal, Tokyo, Oct. 2000.
16.	大内憲明, 飯沼武, 今村恵子, 遠藤登喜子, 大貫幸二, 小田切邦雄, 鈴木総長, 館野之男, 辻一郎, 角田博子, 寺田央, 東野恵利子, 永井宏, 東田善治, 福田護, 掘田勝平, 松本満臣, Tadaoki Morimoto and 横江隆夫土 : マンモグラフィによる乳がん検診の手引き精度管理マニュアル, Japan Medkal Journal, Tokyo, May 2000.
17.	大内憲明, 飯沼武, 今村恵子, 遠藤登喜子, 大貫幸二, 小田切邦雄, 鈴木総長, 館野之男, 辻一郎, 角田博子, 寺田央, 東野恵利子, 永井宏, 東田善治, 福田護, 掘田勝平, 松本満臣, Tadaoki Morimoto and 横江隆夫 : マンモグラフイによる乳がん検診の手引き, Japan Medkal Journal, Tokyo, May 2000.
18.	Tadaoki Morimoto and 笹三徳 : 乳腺外科の要点と盲点(幕内雅敏監修，霞富士雄編集), 文光堂, Tokyo, May 1998.
19.	Tadaoki Morimoto, 石田常博, 福田護, 岡崎稔, 遠藤登喜子, 松本満臣, 小田切邦雄, 木戸長一郎, 永井宏, 土橋一慶, 掘田勝平 and 石栗一男 : マンモグラフィを導入した乳癌検診システムのガイドライン(日本乳癌検診学会ガイドライン作成委員会編), 株式会社篠原出版新社, Tokyo, Nov. 1997.
20.	Tadaoki Morimoto and 笹三徳 : Atlas of Screening Mammography, デジタルプレス, Tokyo, Nov. 1996.
21.	Tadaoki Morimoto and 笹三徳 : 女性のスポーツ医学(越野立夫，武藤芳照，定本明子編), Nankodo, Tokyo, Nov. 1996.
22.	Tadaoki Morimoto and 笹三徳 : 乳房温存療法のすべて -乳癌治療の常識を変えた最新の治療戦略-(渡辺弘監修，福田譲編集), MEDICAL VIEW CO., LTD., Tokyo, Oct. 1994.
23.	Tadaoki Morimoto and 笹三徳 : 癌診療Q&A 乳癌, Iyaku Journal Co., Ltd., Osaka, Aug. 1994.
24.	Tadaoki Morimoto and 笹三徳 : 外科医のための癌治療マニュアル, Medical Review Co.,Ltd, Osaka, Apr. 1994.
25.	Tadaoki Morimoto : 老人保健法による健康診査マニュアル, Japan Medkal Journal, Tokyo, Mar. 1994.
26.	Tadaoki Morimoto : 家庭の医学シリーズ乳がん早期発見と最新治療, 主婦の友社, Tokyo, Mar. 1994.
27.	Tadaoki Morimoto : 改訂乳腺疾患, KANEHARA & CO., LTD., Tokyo, Apr. 1993.
28.	Tadaoki Morimoto : 改訂乳腺疾患, KANEHARA & CO., LTD., Tokyo, Apr. 1993.
29.	Tadaoki Morimoto : PROGRESS IN CANCER CLINICS, MEDICAL VIEW CO., LTD., Tokyo, Mar. 1993.
30.	Tadaoki Morimoto : 産婦人科 1乳房管理, KANEHARA & CO., LTD., Tokyo, Nov. 1991. (Summary) Ⅰ乳房の自己検診 1．自己検診の必要性 2．自己検診の効果 3．自己検診法の実際 Ⅱ乳癌の集団検診 1．乳癌集団検診の標準方式 2．乳癌検診の現状 3．乳癌集団検診の今後の課題
31.	Tadaoki Morimoto : 老人保険法とがん検診に関するシンポジウム, Dai-ichi Hoki Publishing Co.,Ltd., Tokyo, Apr. 1991. (Summary) 1．乳がん検診受診者数の推移 2．富永班における乳がん検診の成績 3．まとめ
32.	Tadaoki Morimoto : 乳癌からの生還-乳がんと闘う最前線外科医達の手記, 株式会社日本小児医事出版社, Tokyo, Aug. 1990.
33.	Tadaoki Morimoto : 乳がん検診<自己検診法と集団検診の手引き>, 社会保険出版社, Tokyo, May 1990.
34.	Tadaoki Morimoto : 乳がん検診<自己検診法と集団検診の手引き>, 社会保険出版社, Tokyo, May 1990.
35.	Tadaoki Morimoto : 忘れ得ぬ患者さん達へ<乳がんと闘う若き医師達の手記>, 株式会社日本小児医事出版社, Tokyo, Feb. 1989.
36.	Tadaoki Morimoto : がん診療 Question & Answer, 六法出版社, 1989.
37.	Tadaoki Morimoto : 乳ガンといわれたら-最新の診断治療から退院後の生活まで-, 主婦の友社, Tokyo, Aug. 1988.
38.	渡辺弘, 阿部令彦, 田口鐵男, 妹尾亘明, 藤間弘行, Tadaoki Morimoto, 石田常博, 富永祐民 and 泉雄勝 : 乳がん集団検診の手引き, 篠原出版, Tokyo, Oct. 1987.
39.	Tadaoki Morimoto and 青木正和 : 老人保険法による健康診査マニュアル, 日本公衆衛生協会, Tokyo, Sep. 1987.
40.	Tadaoki Morimoto, Kansei Komaki and 門田康正 : 癌の臨床別集13 乳癌における内分泌療法の進歩, 篠原出版, Tokyo, Aug. 1987. (Summary) 1．研究対象および方法 2．結果 3．考察
41.	Tadaoki Morimoto : 癌の臨床別集癌の一次予防と二次予防, 篠原出版, Tokyo, Mar. 1987. (Summary) 1．乳がんの発生要因 2．乳がんの一次予防 3．乳房の自己検診の必要性 4．乳がんの集団検診の実態
42.	Tadaoki Morimoto and 原田邦彦 : QUESTIONS&ANSWERS, 六法出版社, Nov. 1986.
43.	Tadaoki Morimoto : PROGRESS IN CANCER CLINICS, MEDICAL VIEW CO., LTD., Tokyo, Sep. 1986.
44.	Tadaoki Morimoto : 乳腺疾患, KANEHARA & CO., LTD., Tokyo, Jul. 1986. (Summary) A.自己検診1)自己検診の必要性2)乳房触診法の種類3)触診の進め方4)自己検診法の実際B.集団検診1)検診方式と検診方法2)乳癌集検の現況3)集検の乳癌検出率4)集検の情報管理と検診効果の評価5)集検の問題点とこれからの対応
45.	Tadaoki Morimoto and Kansei Komaki : 乳がん検診<自己検診法と集団検診の手引き>, 社会保険出版社, Tokyo, Nov. 1984.
46.	Tadaoki Morimoto and Kansei Komaki : 乳がん検診<自己検診法と集団検診の手引き>, 社会保険出版社, Tokyo, Nov. 1984.
47.	Tadaoki Morimoto and Kansei Komaki : 乳がん検診<自己検診法と集団検診の手引き>, 社会保険出版社, Tokyo, Nov. 1984.
48.	Tadaoki Morimoto and 藤野郁野 : 乳ガン子官ガン-賢い女は怖がらない一, 主婦の友社, Tokyo, Oct. 1984.
49.	井上権治 and Tadaoki Morimoto : がん診療Questions & Answers, 六法出版, 1983.
50.	井上権治 and Tadaoki Morimoto : がん診療Questions & Answers, 六法出版, 1983.
51.	井上権治 and Tadaoki Morimoto : がん診療Questions & Answers, 六法出版, 1983.
52.	井上権治 and Tadaoki Morimoto : がん診療Questions & Answers, 六法出版, 1983.
53.	Tadaoki Morimoto, 園尾博司 and 井上権治 : 癌の臨床別冊乳癌·内分泌療法(癌の臨床編), 株式会社篠原出版新社, Tokyo, Nov. 1981.
54.	井上権治 and Tadaoki Morimoto : 外科 Mook l9, KANEHARA & CO., LTD., May 1981.

Academic Paper (Judged Full Paper):

1.	Tadaoki Morimoto, 笠原善郎, 角田博子 and Akira Tangoku : 乳癌検診の過剰診断について―避けるための対応策―, Journal of Japan Association of Breast Cancer Screening, Vol.23, No.3, 337-346, 2014. (Link to Publication Site) ● Publication site (DOI): 10.3804/jjabcs.23.337 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679441763584 ● Search Scopus @ Elsevier (DOI): 10.3804/jjabcs.23.337 (DOI: 10.3804/jjabcs.23.337, CiNii: 1390282679441763584)
2.	Tadaoki Morimoto, 笠原善郎, 角田博子 and Akira Tangoku : In order to reduce over-diagnoses in breast cancer screening, 日本がん検診・診断学会誌, Vol.22, No.2, 155-165, 2014. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1524232505822765184 (CiNii: 1524232505822765184)
3.	Tadaoki Morimoto, Akira Tangoku, Takashi Yamakawa, Masaki Tsuruno and Shigemitsu Takashima : Promotion of quality-controlled mammography alone as a screening modality in Japan., Breast Cancer, Vol.21, No.4, 435-441, 2012. (Summary) BACKGROUND: The rate of breast cancer screening in Japan has not increased, and it is thought that one of the reasons is the principle that mammography (MMG) and clinical breast examination (CBE) be carried out in combination. Nationwide, there is a shortage of physicians qualified to perform CBE, and in some regions mass-screening is performed by MMG alone out of a mobile MMG bus. In Shikoku, MMG is performed alone as a screening examination in Kochi and Ehime Prefectures. METHODS: A comparative analysis of the data generated by MMG alone in breast cancer screening in the four prefectures of Shikoku during the 2005-2009 period was performed. RESULTS: The overall attendance rates, recall, cancer detection, early-stage cancer detection, and the positive predictive value (PPV) were 16.8-24.5, 6.0-12.8, 0.26-0.37, 63.1-79.7, and 2.8-4.3 %, respectively. Almost no differences were seen between the results for MMG alone and combined MMG/CBE screening. In addition, the cancer detection rates based on the Japan Cancer Society's nationwide data were 0.25 % with combined MMG/CBE screening and 0.21 % with MMG alone, showing almost no difference. CONCLUSIONS: No differences were seen between the results (i.e., recall rate, cancer detection rate, early-stage cancer detection rate, PPV) for MMG alone and MMG/CBE screening in the four prefectures of Shikoku compared with the Japan Cancer Society's nationwide data. In order to improve the mammographic screening rate in Japan, quality-controlled mammography as a stand-alone examination should be promoted, and performed biennially for women aged 50-74 years. (Link to Publication Site) ● Publication site (DOI): 10.1007/s12282-012-0410-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23515946 ● Summary page in Scopus @ Elsevier: 2-s2.0-84904719919 (DOI: 10.1007/s12282-012-0410-x, PubMed: 23515946, Elsevier: Scopus)
4.	Kenji Okazaki, Akira Tangoku, Tadaoki Morimoto, Ryosuke Kotani, Keigo Hattori, Emiko Yasuno, Masatake Akutagawa and Yohsuke Kinouchi : Basic study of a diagnostic modality employing a new electrical impedance tomography (EIT) method for noninvasive measurement in localized tissue, The Journal of Medical Investigation : JMI, Vol.57, No.3,4, 205-218, 2010. (Summary) The objective of this study is to develop a device for noninvasive local tissue electrical impedance tomography (EIT) using divided electrodes with guard electrodes and to validate its effectiveness using bioequivalent phantoms. For this purpose, we prepared a measurement device and bioequivalent phantoms, measured the electrical characteristics of the phantoms, and validated the method using the phantoms. Monolayer phantoms mimicking the brain and muscle and bilayer phantoms consisting of muscle and brain layers were prepared. The relative differences between the measured electrical conductivities of the monolayer brain and muscle phantoms and the true values determined by the 4-electrode method were both less than 10%. The relative differences between the measured and true values in the bilayer phantoms were less than 20% in both layers. The biological impedance measurement device that we developed was confirmed to be effective for impedance measurement in bilayer phantoms with different electrical impedances. To develop a device for the early diagnosis of breast diseases, the development of a multi-layer phantom and demonstration of the effectiveness of the device for its examination are necessary. If the device that we developed makes impedance measurement in breast tumors possible, it may be used as a new diagnostic modality for breast diseases. (Keyword) brain / Breast Neoplasms / Electric Impedance / Electrodes / Equipment Design / Female / Humans / Muscles / Phantoms, Imaging / tomography (Tokushima University Institutional Repository) ● Metadata: 70726 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.57.205 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20847519 ● Search Scopus @ Elsevier (PMID): 20847519 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.57.205 (Tokushima University Institutional Repository: 70726, DOI: 10.2152/jmi.57.205, PubMed: 20847519)
5.	高瀬真記, Hideki Nakanishi, Ichiro Hashimoto, Kazuya Matsumoto and Tadaoki Morimoto : 乳房縮小・再建術を行った若年性乳腺肥大症の2例, Journal of Japan Society of Plastic and Reconstructive Surgery, Vol.27, No.9, 636-642, 2007. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570009750813697408 (CiNii: 1570009750813697408)
6.	Taeko Nagao, Yoshimi Bando, Mitsunori Sasa, Tadaoki Morimoto, Nobuya Sano, Toshiyuki Hirose and Akira Tangoku : False-positive in fine-needle aspiration cytology of breast disease can be reduced with p63 immunostaining- A preliminary report, Anticancer Research, Vol.26, No.6B, 4373-4378, 2006. (Summary) Myoepithelial cells of the mammary gland are considered to be a key to distinguishing benign from malignant disease in fine-needle aspiration (FNA) cytology. However, identification of these cells with Papanicolaou staining is not easy. The identification of myoepithelial cells was investigated using p63 antibodies to carry out immunostaining of FNA specimens that had been used at the time of Papanicolaou staining for 37 patients who yielded false-positives in FNA. Positively-stained cells were observed in overlying cell clusters or the background in 67.6% of the patients. There is a possibility that over-diagnosis could have been avoided by performing p63 staining for these patients. The controls consisted of stamp samples of fresh specimens obtained from 23 patients at the time of surgery for invasive carcinoma and the results of p63 immunostaining did not reveal any positive staining of tumor cells. Accordingly, these results indicate that there is a strong likelihood that there is no invasive carcinoma when many p63-positive cells are observed in the tumor cell population or the background and that p63 immunostaining has the potential to aid in reducing false-positives at the time of FNA diagnosis of breast disease. (Keyword) Biopsy, Needle / Breast Neoplasms / DNA-Binding Proteins / False Positive Reactions / Female / Humans / Middle Aged / Trans-Activators / Transcription Factors / Tumor Suppressor Proteins (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17201157 ● Summary page in Scopus @ Elsevier: 2-s2.0-33845916979 (PubMed: 17201157, Elsevier: Scopus)
7.	Masahiko Ikeda, Hiroshi Sonoo, Katsuhiro Tanaka, Junichi Kurebayashi, Tadaoki Morimoto, Akira Tangoku, Kansei Komaki, Tsuyoshi Kataoka, Kiyosuke Ishiguro and Kiyoshi Yoshizawa : Evaluation of safety and efficacy for bi-weekly Docetaxel and 5'-DFUR combination therapy in patients with advanced or recurrent breast cancer--Phase I study, Japanese Journal of Cancer and Chemotherapy, Vol.33, No.6, 767-771, 2006. (Summary) BACKGROUND: A clinical trial of Docetaxel was performed by tri-weekly administration in patients with advanced or recurrent breast cancer. However, careful observation is necessary for outpatients because serious neutropenia often occurs during the therapy. A bi-weekly schedule is recommended since weekly administration requires more visits to the hospital. Docetaxel is proved to express synergistic efficacy in combination with 5'-DFUR by induced dThdPase in vivo. But there are no clinical trials to evaluate efficacy of bi-weekly Docetaxel and 5'-DFUR combination therapy. PURPOSE: To evaluate safety, the recommended dose of Docetaxel and the efficacy of biweekly Docetaxel and 5'-DFUR combination therapy. PATIENTS AND METHODS: Patients with advanced or recurrent breast cancer within 1 regimen of prior chemotherapy and without prior use of both Docetaxel and 5'-DFUR were enrolled. 5'-DFUR was orally administered by 600 mg/day. Docetaxel was intravenously given for at least 2 cycles (8 weeks) by 30 mg/m(2) for level 1, 40 mg/m(2) for level 2 and 50 mg/m(2) for level 3. At each level with 3 cases enrolled,the maximum tolerated dose (MTD) level was defined as that in which 2 or 3 cases showed dose limiting toxicity (DLT). The recommended dose was defined as the dose before MTD level. Therapeutic safety was evaluated by analyses of adverse events with the recommended dose. RESULTS: MTD was in level 3 and the recommended dose of Docetaxel was 40 mg/m(2) of level 2. No DLT was observed in level 2, and this combination therapy seemed safe and feasible for outpatients. In addition, all 6 cases for whom therapeutic efficacy was evaluated expressed a clinical response. (Keyword) Administration, Oral / Aged / Ambulatory Care / Antineoplastic Combined Chemotherapy Protocols / Bone Neoplasms / Breast Neoplasms / Dose-Response Relationship, Drug / Drug Administration Schedule / Female / Floxuridine / Humans / Lung Neoplasms / Maximum Tolerated Dose / Middle Aged / Neoplasm Recurrence, Local / Taxoids (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16770094 ● Search Scopus @ Elsevier (PMID): 16770094 (PubMed: 16770094)
8.	Emiko Yasuno, Xueli Zhao, Yohsuke Kinouchi and Tadaoki Morimoto : A Theoretical Study about Parameter Estimation of Space Distributed Local Tissue Impedance, IEEJ Transactions on Electronics, Information and Systems, Vol.126, No.3, 319-326, 2006. (Summary) In this paper, a new configuration of the electrodes, called divided electrode, is proposed for a short time measurement of bio-impedance in a cross section of a local tissue. Its capability is examined by computer simulations, where a distributed equivalent circuit is used as a model of the tissue. Estimation of impedance parameters is carried out by use of the Gauss-Newton Method. As a result of them, usefulness of the proposed method is confirmed by computer simulations using a typical layered tissue model. (Keyword) bio-impedance / divided electrode / parameter estimation / Gauss-Newton method / EIT(Electrical) Impedance Tomography / divided electrode / parameter estimation / Gauss-Newton method / EIT / Electrical Impedance Tomography (Link to Publication Site) ● Publication site (DOI): 10.1541/ieejeiss.126.319 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204606141952 ● Summary page in Scopus @ Elsevier: 2-s2.0-33644815046 (DOI: 10.1541/ieejeiss.126.319, CiNii: 1390001204606141952, Elsevier: Scopus)
9.	Takako Ichihara, Ayako Tamura, Tuyosi Kataoka, Tadaoki Morimoto, Takako Minagawa and Yumi Kuwamura : Accuracy of tissue thickness of the rectus femoris region as measured by ultrasound, JNI : The Journal of Nursing Investigation, Vol.4, No.2, 79-86, 2006. (Summary) In order to verify the accuracy of the thickness of the rectus femoris muscle and overlying subcutaneous fat as assessed by ultrasound, experiments were conducted on 10 healthy subjects aged over 30 years to assess the following: 1) concordance of measurements made by two different observers; 2) concordance of repeated measurements made by the same observer ; and 3) concordance of repeated measurements made by the same observer with and without an imaging aid(ultrasound gel block). Between two observers with varying experience in ultrasound, no significant difference in measured muscle thickness was observed ; however, there was a significant difference in subcutaneous fat thickness. When measurements were made by the same observer on two separate days, a significant positive correlation was evident for muscle and subcutaneous fat thickness between the first and second tests. While use of the imaging aid was associated with higher concordance of measurements between the first and second tests, the measurements themselves were affected. Although ultrasonic measurement of tissue thickness requires further investigation to minimize intra-observer error and examine correlations with other imaging techniques, the accuracy of the measurements in the present study suggests that clinical application may be possible. (Keyword) leg muscle thickness / leg subcutaneous fat thickness / ultrasonography (Tokushima University Institutional Repository) ● Metadata: 113120 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282676648394752 (Tokushima University Institutional Repository: 113120, CiNii: 1050282676648394752)
10.	Takako Ichihara, Tsuyoshi Kataoka, Ayako Tamura, Yukiko Miyakoshi, Yumi Kuwamura, Takako Minagawa and Tadaoki Morimoto : Changes in the thickness of leg muscles before and after laparotomy, Journal of Health Sciences, Hiroshima University, Vol.5, No.1, 10-15, 2005. (Summary) 広島保健学学会特別講演In order to establish an objective and convenient technique to assess postoperative recovery following laparotomy, in particular activities of daily living, we measured the thickness of muscle tissues by ultrasound sonography. In the present study, the following four muscular compartments were selected: rectus femoris, biceps femoris, extensor digitorum longus, and soleus. These account for a large portion of the systemic skeletal musculature and are important for locomotion. Subjects were 28 patients who underwent moderately invasive surgery for stomach or colon cancer. The results showed that muscle thickness decreased significantly in all four compartments. Rectus femoris exhibited the greatest reduction in thickness and was most affected by short-term or long-term recumbency. Furthermore, for soleus, the tendency was that the longer the recumbency, the greater the wasting. These findings suggest that, of the four areas of the lower limb, rectus femoris is most affected by short-term recumbency and is most suited for objectively assessing postoperative recovery. The results of the present study suggest that it would be effective to design a recovery program focused on maintaining the femoral extensor muscles, which are most affected by short-term recumbency following laparotomy. (Keyword) leg muscle thickness / ultrasonography / laparotomy (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390290699832535040 (CiNii: 1390290699832535040)
11.	Yumi Kuwamura, Ayako Tamura, Takako Minagawa, Takako Ichihara and Tadaoki Morimoto : Content analysis of nursing students' learning though clinical practices with individuals with diabetes mellitus, JNI : The Journal of Nursing Investigation, Vol.4, No.1, 26-33, 2005. (Summary) 学士課程3年次での成人看護学実習で，糖尿病患者を受け持った看護学生(以下，学生)34名の学びの内容について検討することを目的に，学生の記述したレポート内容を質的帰納的に分析した．その結果，4カテゴリー(「療養行動が主体的に実践できるための具体的な支援方法」「学生が感じた困難感や達成感」「療養生活支援のために必要な看護技術」「療養生活を送る対象の理解」)と17サブカテゴリーが抽出された．学生は糖尿病患者を理解し，療養生活行動が主体的に行えるための支援方法を考えていた．そして，患者の行動変容を目指した介入の難しさを実感しながら，患者が主体的に療養行動を実践できるように支援することの大切さについて考え，学生としての立場での看護実践の喜びを感じていた．今後は，学生の学びについて，個々の事例ごとの確認を丁寧に行いながら，学びの内容を卒業時の到達目標と照らし合わせて確認する方法を考案することの必要性が示唆された． (Keyword) 成人看護学学習 / 看護学生 / diabetes mellitus / learning / clinical practice in adult nursing / nursing student (Tokushima University Institutional Repository) ● Metadata: 113113 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287992727808 (Tokushima University Institutional Repository: 113113, CiNii: 1050564287992727808)
12.	Hiromitsu Takizawa, 中野基一郎, Koichiro Kenzaki, Kansei Komaki, Tadaoki Morimoto and Akira Tangoku : 甲状腺髄様癌術後肝転移に対し肝動脈化学塞栓療法が有効であった1例, Journal of Japan Surgical Association, Vol.66, No.7, 1709-1712, 2005. (Keyword) 甲状腺髄様癌 / 転移性肝癌 / 肝動脈化学塞栓療法 (Link to Publication Site) ● Publication site (DOI): 10.3919/jjsa.66.1709 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204849234560 ● Search Scopus @ Elsevier (DOI): 10.3919/jjsa.66.1709 (DOI: 10.3919/jjsa.66.1709, CiNii: 1390001204849234560)
13.	Yumi Kuwamura, Takako Minagawa, Takako Ichihara, Ayako Tamura and Tadaoki Morimoto : Literature review of nursing interventions and evaluations for the persons with diabetes mellitus in Japan, JNI : The Journal of Nursing Investigation, Vol.3, No.2, 79-90, 2005. (Summary) 医学中央雑誌Web版(Ver．3)を用いて，1994年から2004年の過去10年間に，糖尿病を有する人を対象に，看護師が行った教育や指導などの看護介入行為のうち，その効果が患者の持つ問題の解決に有効であると報告されている研究論文の分析を行い，以下の結果が得られた． 1．対象となった論文は16編あった． 2．介入内容は食に関連するものが11編あった．看護師は，患者の持つ問題の明確化，その具体的な対応，到達目標の設定に対して，患者が主体的に取り組むことができるように，患者の情緒面も含めて援助していた． 3．介入内容の評価を看護師が行っていたものは13編あった．評価項目は糖尿病の血糖コントロール指標としてのHbA1cがすべての文献で用いられていた．以上のことより，今後は，患者の自己管理を支援するために，患者が一貫して主体的に取り組めるような介入方法を開発することが必要である．また，介入結果の評価においては，血糖コントロール指標に加えて，患者の行動や心理の変化を適切に評価できる評価方法や評価指標を開発する必要があると考えられた． (Keyword) 糖尿病を有する人 / persons with diabetes mellitus / nursing interventions / evaluations (Tokushima University Institutional Repository) ● Metadata: 113106 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287992725120 (Tokushima University Institutional Repository: 113106, CiNii: 1050564287992725120)
14.	王丸明子, 寺田央, 堀田勝平, 岡崎正敏, 遠藤登喜子, 今村惠子, 大貫幸二, 東野英利子, 逸見典子, 木村千明, 土橋一慶, 福田護 and Tadaoki Morimoto : 施設画像評価委員会の現状と再評価施設における成果, Journal of Japan Association of Breast Cancer Screening, Vol.14, No.1, 48-53, 2005. (Keyword) マンモグラフィ / 画像評価 / 品質管理 (Link to Publication Site) ● Publication site (DOI): 10.3804/jjabcs.14.48 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573105974997915520 ● Search Scopus @ Elsevier (DOI): 10.3804/jjabcs.14.48 (DOI: 10.3804/jjabcs.14.48, CiNii: 1573105974997915520)
15.	Yumi Kuwamura, Takako Ichihara, Takako Minagawa, Ayako Tamura, Tadaoki Morimoto and Hiroko Kondo : 臨地実習での学習内容に対する学生自己評価の変化-成人看護学臨地実習で興味·関心のあるテーマを課題学習に導入した場合と導入しなかった場合の比較から-, JNI : The Journal of Nursing Investigation, Vol.3, No.1, 11-21, 2004. (Summary) 臨地実習での学びを効果的にするために，3年課程3年次学生を対象に臨地実習固有の学習内容を用いた学生自己評価を継続しているが，自己評価得点は，実習開始前から中期にかけて上昇しても，中期から終了時には上昇しない傾向が続いた．そのため，成人看護学臨地実習(急性期)では，2003年度後期に学生の興味・関心のあるテーマを課題学習として導入することを試みた．課題学習を導入した2003年度後期(36人)と導入しなかった2001年度後期(34人)の自己評価得点の差を統計的に検定することにより，課題学習の効果を検討した．その結果，以下の結果が得られた． ① 課題学習のテーマを決定する過程において，学生は，自己の学習状況を振り返り，整理することができた． ② 終了時の自己評価では，課題学習を導入しなかった2001年度では4．0点以上の高得点の項目が20項目であったのに対し，課題学習を導入した2003年度では40項目もあり，学生は学習内容に到達したと高く評価していた．これらのことより，興味・関心のあるテーマを課題学習として導入することは，学生の自発性を高め，学習内容に対する学生の到達度の認識を高める可能性があると考えられた． (Keyword) clinical practice / 学生自己評価 / 興味·関心 / 課題学習 (Tokushima University Institutional Repository) ● Metadata: 113095 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050001338017589888 (Tokushima University Institutional Repository: 113095, CiNii: 1050001338017589888)
16.	Yuken Ohmine, Tadaoki Morimoto, Yohsuke Kinouchi, Tadamitsu Iritani, Mieko Takeuchi, Mari Haku and Hiromu Nishitani : Basic study of new diagnostic modality according to non-invasive measurement of the electrical conductivity of tissues, The Journal of Medical Investigation : JMI, Vol.51, No.3,4, 218-225, 2004. (Summary) The purposes of this study were to estimate the electrical conductivity of tissues by non-invasively measuring the electrical bio-impedance, to develop a new method for tissue diagnosis, i.e., electrical impedance tomography (EIT). Tissue models were first designed taking into consideration the distribution of the fat tissue, muscle and bone in the human forearm, and then the intra-tissue distributions of electrical potential and field, and the electrical impedance in the models was theoretically analyzed by the three-dimensional finite element method. The electrical impedance of both forearms was measured in healthy human subjects, and estimated the electrical conductivity of individual local tissues. The results of the analysis showed that the distributions of electrical potential and field were affected by the presence of fat tissue but not by the presence or absence of bone. In addition, as a result of calculation of the electrical resistance of the extracellular fluid (Re) in each model, it was found that the value of bio-impedance was influenced by the presence of fat tissue, and the value of bio-impedance was increased by the intervention of a fat layer. The electrical conductivity estimated by fitting the observed values to the values obtained by finite element analysis was 0.40 S/m and 0.15 S/m for male muscle and fat tissue, and 0.35 S/m and 0.11 S/m for female muscle and fat tissue, respectively. The sex difference in the slope of linear approximation in the estimation of electrical conductivity of the males and females was thought to be due to sex differences in the properties and structure of fat tissue. These results suggest that local tissues can be diagnosed differentially and electrically by percutaneous measurement of local bio-impedance and subsequent estimation of the electrical conductivity of each tissue. (Keyword) electrical bio-impedance / electrical conductivity / measurement / non-invasive electrode / soft tissue (Tokushima University Institutional Repository) ● Metadata: 110744 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.51.218 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15460909 ● Search Scopus @ Elsevier (PMID): 15460909 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.51.218 (Tokushima University Institutional Repository: 110744, DOI: 10.2152/jmi.51.218, PubMed: 15460909)
17.	Yumi Kuwamura, Ayako Tamura, Takako Ichihara, Takako Minagawa and Tadaoki Morimoto : Self-evaluation Study of Nursing Students' Recognition of Their Degree of Achievement of Educational Goals in Clinical Practice, JNI : The Journal of Nursing Investigation, Vol.2, No.1, 7-15, 2004. (Summary) Objective: The purpose of this study was to :assess the nursing students' recognition of their achievement of their educational goals in clinical practice ;and discuss the clinical teaching interventions of nursing education by means of self-evaluation for the students at a 3-year nursing junior college. Methods: We used the self-evaluation questionnaire (62 questions). Self-evaluation was performed three times: the first was before clinical practice (hereinafter first evaluation), at the middle point of clinical practice (middle evaluation) and after the clinical practice (final evaluation). Results: 1. There ware 2patterns in self-evaluation scores. One was rise, and the other was not rise by comparison between first evaluation and final evaluation. 2. Only 7 scores were improved among 62 questions.They were classified cognitive domain, and they were recognized by the nursing students to be achieved of their educational goals. 3. In the final evaluation there were 14 items for which they had not achieved their educational goals. They were the following items: comparing their clinical practice experience with nursing theory, performing clinical practice while thinking about the nature of nursing and using communication skills, and the process of nursing diagnosis. Conclusions: Nursing students need educational intervention. That is, they need teachers to teach them, or to think with them, how to use the nursing process to overcome patients' problems in each clinical situation by means of communication skills. It is also important to make effective use of conferences at school to so that student's can shore experiences. (Keyword) self-evaluation / clinical practice / nursing education / achievement of educational goals / nursing students (Tokushima University Institutional Repository) ● Metadata: 113086 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812994297472 (Tokushima University Institutional Repository: 113086, CiNii: 1050282812994297472)
18.	Mari Haku, Mieko Takeuchi, Tadaoki Morimoto, Shuji Yamano and Keiko Takebayashi : Relationship between mammary gland structures during pregnancy and breast-feeding, JNI : The Journal of Nursing Investigation, Vol.2, No.1, 16-20, 2004. (Summary) Study Purpose Diagnostic indices for prediction of breast milk production and assessment of care necessary for mammary gland structure during the pregnancy period were investigated. Methods Development of mammary gland during the pregnancy period was examined via ultrasound methodology. Each subject underwent three measurements once per trimester. Quantity of post-partum breast milk production was also measured ; furthermore, the relationship between mammary gland image and production quantity was evaluated. Results and conclusion As previously reported, mammary gland reaches a certain level of development during the course of pregnancy. Four distinct types of developmental pattern were observed. Mammary gland exhibited remarkable development up to the 15th week of pregnancy in comparison with non-pregnant adult females in type 1. In type 2, mammary gland displayed significant development from the 16th to the 35th week of pregnancy. In types 3 and 4, mammary gland tissue development, which was apparent from 35 weeks, was characterized by gland thickness of > 20 mm and < 20 mm, respectively. Among these four types, type 1 mammary gland demonstrated the largest level of breast milk production. Therefore, we suggest that understanding with respect to mammary gland structure during pregnancy contributes toward individual support in breast-feeding following childbirth. (Keyword) mammary gland structure / breast-feeding / ultrasound (Tokushima University Institutional Repository) ● Metadata: 113087 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762947718912 (Tokushima University Institutional Repository: 113087, CiNii: 1050845762947718912)
19.	Takako Minagawa, Ayako Tamura, Takako Ichihara, Yumi Kuwamura and Tadaoki Morimoto : Analysis of cases applying shiatsu massage for nursing care, JNI : The Journal of Nursing Investigation, Vol.2, No.1, 27-36, 2004. (Summary) Shiatsu massage is one of the common therapeutic methods in oriental medicine, and is considered to be useful for supporting conventional medicine. However, there has been little evidence for its effects. In this report, papers dealing with the application of shiatsu massage to nursing care are extracted from literature, in order to clarify the effects and problems of this method as a nursing care. Papers containing studies of shiatsu massage by nurses as a nursing care were extracted from literature by using the Japan Centra Revuo Medicina (WEB issue, version 3), and those published during 10 years from 1993 to 2003 were analyzed. It was found that the relaxation effects by shiatsu massage were reported for various symptoms. Among these, 10 papers were analyzed in detail, which described the effects on relief of the following symptoms; dysphasia (constipation) (5 papers), nausea and vomiting at cancer chemotherapy (3 papers), pain from cancer (1 paper), and edema generated after lymphadenectomy (1 paper). It was found from these papers that shiatsu massage is effective for patients who have positive thinking to this therapy. On the other hand, the necessity of further experiments was indicated because of the lack of common methods and effects in this therapy; for example, position, force, frequency, etc., should be optimized. (Keyword) shiatsu massage / oriental medicine / nursing care (Tokushima University Institutional Repository) ● Metadata: 113089 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287971009408 (Tokushima University Institutional Repository: 113089, CiNii: 1050564287971009408)
20.	Takako Minagawa, Ayako Tamura, Yumi Kuwamura and Tadaoki Morimoto : Study on the difference in observation points between students before and after experiencing related nursing practice, --- On the observations of vital signs and oxygen inhalation by use of an acute stage dummy ---, JNI : The Journal of Nursing Investigation, Vol.2, No.1, 1-6, 2004. (Summary) The difference in observation points for postoperative patients between two groups of nursing students was analyzed in terms of the students' experience of related training for the purpose of improving the training tutorial. The object was 72 students before starting adult nursing training (nursing of the acute stage patient) and 45 students after the training termination. The students were allowed to observe an acute stage dummy for 10 minutes and to write down the observation results of the 'drains and tubes', 'fluid therapy', and 'vital signs'. The descriptions about these three items were analyzed by classifying them into 'correct', 'mistaken', and 'no description'. The main results are as follows. The percentage of nursing students who correctly reported the 'heart rate on the monitor' was lower in the group after training termination comparing to the other group. As for the 'oxygen flow rate', many mistakes were found in the both groups, indicating the technical problem on the monitoring of the oxygen flow meter. In the both groups, no student described 'core temperature on the monitor' and 'oxygen concentration'. These results suggest the necessity of developing tutorial method to improve the students' observation ability for postoperative patients. The use of an acute stage dummy would be helpful for the practice of observations. It is also necessary for the teachers to check the observation behaviors of students during the exercises and practices in order to make the observations correct. (Keyword) 術後急性期 / 観察 / 急性期モデル人形 (Tokushima University Institutional Repository) ● Metadata: 113085 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287971008000 (Tokushima University Institutional Repository: 113085, CiNii: 1050564287971008000)
21.	古妻嘉一, 遠藤登喜子, 岩瀬拓士, 大貫幸二, 永井宏, 東野英里子, 角田博子, 大村峯夫, 増田慎三, 中谷守一, Tadaoki Morimoto and 大内憲明 : マンモグラフィ検診の精度管理に及ぼす読影講習会企画の意義, Journal of Japan Association of Breast Cancer Screening, Vol.13, No.1, 63-68, 2004.
22.	Xueli Zhao, Yohsuke Kinouchi, Emiko Yasuno, Dayong Gao, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : A New Method for Noninvasive Measurement of Multilayer Tissue Conductivity and Structure Using Divided Electrodes, IEEE Transactions on Biomedical Engineering, Vol.51, No.2, 362-370, 2004. (Summary) This paper outlines a new method for measuring multilayer tissue conductivity and structure by using divided electrodes, in which current electrodes are divided into several parts. Our purpose is to estimate the multilayer tissue structure and the conductivity distribution in a cross section of the local tissue by using bioresistance data measured noninvasively. The effect of the new method is assessed by computer simulations using a typical two-dimensional (2-D) model. In this paper, the conductivity distribution in the model is analyzed based on a finite difference method (FDM) and a steepest descent method (SDM). Simulation results show that the conductivity values of skin, fat, and muscle layers can be estimated with an error of less than 0.1%. When random noise at various levels is added to the measured resistance values, estimates of the conductivity values for skin, fat, and muscle layers are still reasonably precise: their root mean square errors are about 1.06%, 1.39%, and 1.61% for 10% noise. In a 2-D model, increasing the number of divided electrodes permits simultaneous estimates of tissue structure and conductivity distribution. Optimal configuration for divided electrodes is examined in terms of dividing pattern. (Keyword) Adipose Tissue / Algorithms / Animals / Computer Simulation / Electric Conductivity / Electrodes / Humans / Models, Biological / Muscle, Skeletal / Reproducibility of Results / Sensitivity and Specificity / Skin Physiological Phenomena / Tomography (Link to Publication Site) ● Publication site (DOI): 10.1109/TBME.2003.820403 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14765709 ● CiNii @ National Institute of Informatics (CRID): 1571698601693132928 ● Search Scopus @ Elsevier (PMID): 14765709 ● Search Scopus @ Elsevier (DOI): 10.1109/TBME.2003.820403 (DOI: 10.1109/TBME.2003.820403, PubMed: 14765709, CiNii: 1571698601693132928)
23.	Masako Minato, Chieko Hirose, Mitsunori Sasa, Hiroshi Nishitan, Yukiko Hirose and Tadaoki Morimoto : 3-Dimensional Computed Tomography Lymphography-Guided Identification of Sentinel lymph Nodes in Breast Cancer Patients Using Subcutaneous Injection of Nonionic Contrast Medium :A clinical Trial, Journal of Computer Assisted Tomography, Vol.28, No.1, 46-51, 2004. (Summary) Simple and reliable identification methods for sentinel lymph nodes (SLNs) which do not use radioisotope are essential for early breast cancer patients in community hospitals in Japan. The purpose of this paper is to demonstrate the feasibility and efficacy of computed tomography (CT) lymphography for SLN detection. The study included 15 cases with T1 or T2 breast cancer. After subcutaneous injection of 1 mL of iopamidol in 1 subareolar area of the affected breast, CT scanning was carried out and 3-dimensional (3D) CT images were created. SLNs predicted from images and CT values were assessed as to whether they were identical to those identified by the dye method. An enhanced lymph vessel draining into SLN was demonstrated in 11 cases (73%) and an enhanced SLN in 10 cases (67%). 3D images clearly revealed the anatomic relationship between lymph vessels, SLN, and the surrounding structures. In addition, SLN could be predicted by the change of CT value in the time-course in another case. In total, SLN in 13 cases (87%) could be predicted. All SLNs suggested from CT lymphography were identified by the dye method. No significant adverse effect was noted in any case. The present clinical trial indicated that subcutaneous injection of nonionic contrast medium with CT scanning seems to be a promising method for the demonstration of a draining lymph vessel and SLN. The CT value time-course may also provide some important information. Further trials will be needed for the successful establishment of this CT lymphography-guided method for SLN identification. (Keyword) breast cancer / computed tomography / indirect lymphography / nonionic contrast medium / sentinel lymph node (Link to Publication Site) ● Publication site (DOI): 10.1097/00004728-200401000-00007 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14716231 ● Search Scopus @ Elsevier (PMID): 14716231 ● Search Scopus @ Elsevier (DOI): 10.1097/00004728-200401000-00007 (DOI: 10.1097/00004728-200401000-00007, PubMed: 14716231)
24.	Tadaoki Morimoto, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Yoshimi Miki and Mitsunori Sasa : Evaluation of a new rehabilitation program for postoperative patients with breast cancer, Nursing & Health Sciences, Vol.5, No.4, 275-282, 2003. (Summary) The purpose of the present study was to evaluate the efficacy of a newly designed rehabilitation program for postoperative patients with breast cancer. This was achieved through examinations to clarify the range of motion (ROM) of the shoulder joint, postoperative pain and recovery of activities of daily living (ADL). The ROM of the shoulder joint was evaluated with respect to five items and determinations were carried out five times. Patients were orally questioned four times regarding their pain after surgery, movement-associated chest pain, pain at night and operative wound pain. Evaluation of the ADL after discharge was conducted using a three-level rating method at postoperative week 4 and week 12. A total of 72 patients were studied, comprising 39 who underwent pectoral muscle-conserving mastectomy and 33 who underwent breast-conserving surgery. The arm movement of forward raising showed the greatest decline, followed by lateral raising of the arm. Postoperative time-course changes in internal/external arm rotation, as well as backward arm raising were slight. Comparison of the operative procedures revealed differences only for lateral arm raising at postoperative week 4, while there were no differences in any of the shoulder joint movements. Lowering of the ROM of the shoulder joint was more marked at an earlier time (week 1 to week 2) after surgery, but it was not statistically significant. Pain at night and operative wound pain were prolonged over the period, and reported in postoperative week 1 to week 12 by 3-15% of patients. All ADL items became almost normal in approximately 90% of patients at postoperative week 4. The efficacy of the present rehabilitation program early after surgery was demonstrated in terms of recovery of ADL as well as the ROM of the arm on the affected side. (Keyword) Activities of Daily Living / Adult / Aged / Breast Neoplasms / Chest Pain / Exercise / Female / Hand Strength / Humans / Mastectomy / Mastectomy, Segmental / Middle Aged / Pectoralis Muscles / Postoperative Period / Program Evaluation / Range of Motion, Articular / Shoulder Joint / Time Factors (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1442-2018.2003.00163.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14622379 ● Search Scopus @ Elsevier (PMID): 14622379 ● Search Scopus @ Elsevier (DOI): 10.1046/j.1442-2018.2003.00163.x (DOI: 10.1046/j.1442-2018.2003.00163.x, PubMed: 14622379)
25.	Ayako Tamura, Tadaoki Morimoto, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, 三木好美, 青山容子, 根本真由美, 平岡朗子, 蘇武由美 and 笹三徳 : 乳癌術後患者の早期機能回復訓練実施による肩関節可動域の評価, 日本リハビリテーション看護学会学術大会誌第1集, 143-146, 2003.
26.	古妻嘉一, 遠藤登喜子, 岩瀬拓士, 大貫幸二, 永井宏, 東野英里子, 角田博子, 大村峯夫, 増田慎三, 中谷守一 and Tadaoki Morimoto : アンケート調査によるマンモグラフイ読影講習会の精度管理(6), Journal of Japan Association of Breast Cancer Screening, Vol.12, No.2, 185-192, 2003.
27.	Ayako Tamura, Tadaoki Morimoto, Hiroko Kondo, Takako Ichihara, Yumi Kuwamura, Takako Minagawa, 三木好美 and 笹三徳 : 乳癌縮小手術を受けた患者の術後回復過程に関する研究(1), JNI : The Journal of Nursing Investigation, Vol.1, No.1, 19-25, 2003. (Summary) 本研究は，乳癌で胸筋切除を伴わない縮小手術を受けた患者の肩関節の可動域の回復遅延ケースにおける，回復遅延に関わる要因を明らかにし，術後の機能回復訓練時の患者指導に活かすことを目的とした．対象は乳房温存術や胸筋温存乳房切除術を受けた乳癌術後患者39名で，機能回復訓練を術後12週間縦断的に観察しえたケースにおいて，肩関節可動域の回復状態を良好群と遅延群の2群にわけ，その2群間の比較を，肩関節可動域や疼痛・日常生活動作から観察した．その結果，遅延群ケースから肩関節可動域の回復に関わる主要因として，創部の動作時の疼痛が考えられ，2つめの要因としてこの動作時の疼痛の発生により術後必要とされる運動を行わないことで，さらに回復を遅延させていることが考えられた．よって，動作時の疼痛を訴え，肩関節可動域の回復の遅れを認める例には，機能回復訓練状態の観察と術後12週目までの継続的な運動の必要性の指導のほかに，肩関節可動域訓練を看護師が患者とともに一緒に行うという確実な実施が，肩関節の可動域の回復遅延の予防となると考えられた． (Keyword) 乳癌 / 縮小手術 / 術後早期 / 肩関節可動域 / 回復遅延要因 / breast cancer / early postoperative period / shoulder joint range of motion / factors causing delayed recovery (Tokushima University Institutional Repository) ● Metadata: 113078 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812994294016 (Tokushima University Institutional Repository: 113078, CiNii: 1050282812994294016)
28.	Ayako Tamura, Tadaoki Morimoto, Hiroko Kondo, Takako Ichihara, Yumi Kuwamura, Takako Minagawa, 三木好美 and 笹三徳 : 乳癌縮小手術(乳房温存術,胸筋温存乳房切除術)を受けた患者の術後回復過程に関する研究(2), JNI : The Journal of Nursing Investigation, Vol.1, No.1, 26-33, 2003. (Summary) 成人で手術後リハビリテーションの必要な患者の看護ケアの開発·改善の一助にすることを目的に，温存術と切除術を受けた乳癌患者39名の術式別回復状態の比較を行った．切除術の1週目に握力が，有意に低下し，運動プログラムに，等尺性運動を取り入れることが示唆された． (Keyword) breast cancer / shoulder joint range of motion / 胸筋温存乳房切除術 / 術式選択 / 情報提供 (Tokushima University Institutional Repository) ● Metadata: 113079 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050001338017584384 (Tokushima University Institutional Repository: 113079, CiNii: 1050001338017584384)
29.	古妻嘉一, 遠藤登喜子, 岩瀬拓士, 大貫幸二, 永井宏, 東野英利子, 角田博子, 大村峯夫, 増田慎三, 中谷守一, Tadaoki Morimoto and 大内憲明 : マンモグラフィ読影講習会の精度管理の現状と改善策の検討, Journal of Japan Association of Breast Cancer Screening, Vol.12, No.1, 30-37, 2003. (Keyword) 乳癌検診 / マンモグラフィ講習会 / アンケート調査 / 精度管理
30.	Takeshi Tominaga, Hiroki Koyama, Tetsuya Toge, Shigeto Miura, Keizo Sugimachi, Susumu Yamaguchi, Koichi Hirata, Yasumasa Monden, Yasuo Nomura, Masakazu Toi, Izo Kimijima, Shinzaburo Noguchi, Hiroshi Sonoo, Kazuaki Asaishi, Tadashi Ikeda, Tadaoki Morimoto, Jun Ota, Yasuo Ohashi and Osahiko Abe : Randomized Controlled Trial Comparing Oral Doxifluridine Plus Oral Cyclophosphamide With Doxifluridine Alone in Women With Node-Positive Breast Cancer After Primary Surgery, Journal of Clinical Oncology, Vol.21, No.6, 991-998, 2003. (Summary) We compared the therapeutic usefulness of doxifluridine (5'-DFUR) alone and a combination of 5'-DFUR plus cyclophosphamide (CPM), both of which are considered effective against advanced and recurrent breast cancer, to determine which treatment is more beneficial as postoperative adjuvant chemotherapy. A total of 1,131 women with node-positive primary breast cancer were randomly assigned after primary surgery to receive 5'-DFUR alone or 5'-DFUR plus CPM. All patients initially received 5'-DFUR in an oral dose of 1,200 mg/d for 4 weeks, starting 4 weeks after surgery. Chemotherapy was then not given for 2 weeks. Patients in the 5'-DFUR group subsequently received five 4-week cycles of treatment consisting of oral 5'-DFUR (1,200 mg/d) for the first 2 weeks and no chemotherapy for the next 2 weeks. Those assigned to the 5'-DFUR plus CPM group also received oral CPM 100 mg/d for the first 2 weeks and no chemotherapy for the next 2 weeks. Women 50 years or older concurrently received 20 mg/d of tamoxifen for 2 years in both groups. Of the 1,088 eligible women, 546 were assigned to receive 5'-DFUR alone and 542 were assigned to receive 5'-DFUR plus CPM. Overall disease-free survival was significantly better in women who received 5'-DFUR plus CPM than in those who received 5'-DFUR alone (log-rank test, P =.021). Toxic effects occurred in 20.0% of patients (109 of 546) in the 5'-DFUR group and 32.3% of patients (175 of 542) in the 5'-DFUR plus CPM group (chi(2) test, P <.001). Combination therapy with 5'-DFUR plus CPM is more effective in preventing recurrence than 5'-DFUR alone. (Keyword) Administration, Oral / Adult / Aged / Antimetabolites, Antineoplastic / Antineoplastic Combined Chemotherapy Protocols / Breast Neoplasms / Chemotherapy, Adjuvant / Cyclophosphamide / Disease-Free Survival / Drug Administration Schedule / Female / Floxuridine / Humans / Japan / Lymphatic Metastasis / Middle Aged / Neoplasm Staging / Odds Ratio / Survival Analysis / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1200/JCO.2003.06.014 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12637462 ● Search Scopus @ Elsevier (PMID): 12637462 ● Search Scopus @ Elsevier (DOI): 10.1200/JCO.2003.06.014 (DOI: 10.1200/JCO.2003.06.014, PubMed: 12637462)
31.	Takako Ichihara, 西亀正之, Ayako Tamura, Tadaoki Morimoto and 西正晴 : 超音波検査法による開腹術後患者の下肢筋組織厚および皮下脂肪厚の評価, Journal of Health Sciences, Hiroshima University, Vol.2, No.2, 12-21, 2003. (Summary) 術後の健康回復の促進に向けた看護ケアの基礎的資料を得るため,超音波診断装置(周波数は7.5MHz)を用いて,開腹による胃あるいは大腸手術を受けた患者を対象に,手術経過に伴う下肢の筋組織厚および皮下脂肪厚の変化を明らかにした.術前,術後離床日,術後10日目,術後20日目の合計4回,下肢の大腿直筋上,大腿二頭筋上,長指伸筋上,ヒラメ筋上にプローブを当て,組織厚を測定した.開腹による胃または大腸手術を行なった患者のうち,合計4回の測定結果が得られた16名を分析対象とした.4箇所の測定部位の筋組織厚および皮下脂肪厚をそれぞれ合計し,筋組織厚総和および皮下脂肪厚総和を算出し,術前値との比較を行なった.その結果,下肢の筋組織厚総和は,術後離床日,術後10日目,術後20日目に有意な減少を認めた.一方,下肢の皮下脂肪厚総和は,術後には有意な減少を認めず,ほとんど変化しないことが明らかになった.胃手術群と大腸手術群の比較においては,胃手術群は,術後10日目から術後20日目にさらに減少し,回復の傾向を示さなかったが,大腸手術群は,術後10日目から術後20日目に下肢の筋組織厚が回復の傾向を示した.よって,開腹術後患者,特に胃手術患者に対して,より細やかな看護観察と栄養評価,および食事摂取量を増やす看護介入の必要性が示唆された.In order to obtain basic data for use in postoperative nursing care intended to promote the recovery of patients after surgery, the authors examined postoperative changes in lower limb muscular tissue thickness and subcutaneous fat thickness by ultrasonography (7.5 MHz) in patients who underwent open surgery of the stomach or large intestine. The ultrasound probe was placed on the skin above the following muscles: quadriceps femoris, biceps femoris muscle, extensor digitorum longus, and soleus. Measurements were taken on 4 occasions: before surgery, and on the 1st, 10th and 20th day after postoperative mobilization. Of all patients who underwent open surgery of the stomach or large intestine, 16 patients were selected for analysis and ultrasonic measurements. Muscular tissue and subcutaneous fat thicknesses at each of the four sites of measurement were totaled to yield measures of total muscular tissue and total subcutaneous fat. Postoperative and preoperative parameters were then compared. The total lower limb muscular tissue thickness at each of the 4 postoperative measurement points was significantly less than the preoperative thickness, whereas the total lower limb subcutaneous fat thickness showed no significant decrease after surgery and remained almost unchanged from the preoperative value. Comparing patients undergoing different types of surgery, leg muscular tissue thickness showed a tendency to recover on the 10th and 20th day after surgery in the colorectal surgery group, while the gastric surgery group showed further decreases in this parameter on the 10th and 20th day, with no trend towards recovery evident over the timeframe investigated. These results suggest the necessity of active nursing intervention for patients after open gastric surgery.G2 (Keyword) 下肢組織厚 / 超音波検査法 / 開腹手術 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390572174809224704 (CiNii: 1390572174809224704)
32.	岡崎正敏, 石栗一男, 今村恵子, 遠藤登喜子, 大内憲明, 大貫幸二, 王丸明子, 小田切邦雄, 寺田央, 土橋一慶, 福田護, 堀田勝平 and Tadaoki Morimoto : マンモグラフィ検診精度管理中央委員会(精中委)·施設画像評価委員会の活動状況, 日本がん検診·診断学会誌, Vol.10, No.2, 177-182, 2003. (Keyword) breast cancer / マンモグラフィ検診 / 画像評価
33.	Masako Minato, Chieko Hirose, Mitsunori Sasa, Hiroshi Nishitan, A. HORI and Tadaoki Morimoto : Axillary 3D CT Imaging with Lymphoscintigraphy Is Useful for Sentinel Node Biopsy in Breast Cancer, Anticancer Research, Vol.23, No.3C, 2935-2940, 2003. (Summary) This study examined whether 3D CT imaging with lymphoscintigraphy (LSG) is useful when performing sentinel node biopsy (SNB) in a community hospital where radioisotope with gamma-probe (RI method) is unavailable. From June to November 2002, 35 T1/T2 clinically node-negative breast cancer patients underwent LSG in a university nuclear medicine department. Skin areas above LSG hot spots were marked, helical CT scanning was performed and axillary 3D images were created in our hospital. The SLN predicted from the 3D images were examined for agreement with the dye method. SLNs were detected with dye in 32 out of 35 patients (91.4%). In 31 of those 32 (96.9%), the SLN predicted from 3D CT images was the same. Even in the 3 dye-negative patients, CT imaging predicted the SLN. SNB including sampling was successful in 34 patients (97.1%). 3D CT imaging with LSG enables SNB even if the RI method is impossible. (Keyword) sentinel lymph node / sentinel node biopsy / breast cancer / 3D CT imaging / lymphoscintigraphy (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12926139 ● Summary page in Scopus @ Elsevier: 2-s2.0-0043125487 (PubMed: 12926139, Elsevier: Scopus)
34.	Xueli Zhao, Yohsuke Kinouchi, Emiko Yasuno, Dayong Gao, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : A New Method for Non-Invasive Measurement of Multi-layer Tissue Conductivity and Structure Using Divided Electrodes, IEEE Transactions on Biomedical Engineering, Vol.1, No.11, 1-10, 2002.
35.	古妻嘉一, 遠藤登喜子, 岩瀬拓士, 大貫幸二, 永井宏, 東野英利子, 角田博子, 大村峯夫, 増田慎三, 中谷守一 and Tadaoki Morimoto : アンケート調査によるマンモグラフィ読影講習会の精度管理[5], Journal of Japan Association of Breast Cancer Screening, Vol.11, No.2, 199-212, 2002. (Keyword) マンモグラフィ講習会 / アンケート調査 / 精度管理 / グループ講習講師 / 講師レベル向上 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204461127296 (CiNii: 1390001204461127296)
36.	笹三徳, Tadaoki Morimoto, 田中隆, 相良安信 and 山口哲央 : 徳島トライアルの成績から見た49歳以下女性に対するマンモグラフィ併用乳癌検診, Journal of Japan Association of Breast Cancer Screening, Vol.11, No.2, 149-154, 2002. (Keyword) breast cancer / マンモグラフィ併用検診 / 49歳以下女性 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571417125083414528 (CiNii: 1571417125083414528)
37.	Xueli Zhao, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : Estimation of Multi-Layer Tissue Conductivities from Non-invasively Measured Bioresistances Using Divided Electrodes, IEICE Transactions on Information and Systems, Vol.E85-D, No.6, 1031-1038, 2002. (Summary) To estimate inner multi-layer tissue conductivity distribution in a cross section of the local tissue by using bioresistance data measured noninvasively on the surface of the tissue, a measurement method using divided electrodes is proposed, where a current electrode is divided into several parts. The method is evaluated by computer simulations using a three-dimension (3D) model and two two-dimension (2D) models. In this paper, conductivity distributions of the simplified (2D) model are analyzed based on a combination of a finite difference method (FDM) and a steepest descent method (SDM). Simulation results show that conductivity values for skin, fat and muscle layers can be estimated with an error less than 0.1%. Even though different strength random noise is added to measured resistance values, the conductivities are estimated with reasonable precise, e.g., the average error is about 4.25% for 10% noise. The configuration of the divided electrodes are examined in terms of dividing pattern and the size of surrounding guard electrodes to confine and control the input currents from the divided electrodes within a cross sectional area in the tissue. (Keyword) bioimpedance / FEM / FDM / divided electrodes / tissue conductivity (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573668927255636608 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036614422 (CiNii: 1573668927255636608, Elsevier: Scopus)
38.	Haiying Zhao, Tadaoki Morimoto, Mitsunori Sasa and Keisuke Izumi : An immunohistochemical evaluation of biomarkers and apoptotic cells in ductal carcinoma in situ of breast, Breast Cancer, Vol.9, No.2, 118-126, 2002. (Keyword) DCIS / breast cancer / Immunohistochemical methods / Proliferative marker / Invasive marker
39.	古妻嘉一, 遠藤登喜子, 岩瀬拓士, 大貫幸二, 永井宏, 東野英利子, 角田博子, 大村峯夫, 増田慎三, 中谷守一 and Tadaoki Morimoto : アンケート調査によるマンモグラフィ読影講習会の精度管理[4], Journal of Japan Association of Breast Cancer Screening, Vol.11, No.1, 72-80, 2002. (Keyword) 乳がん検診 / マンモグラフィ試験 / アップグレイド / アンケート調査 / 精度管理 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679439397248 (CiNii: 1390282679439397248)
40.	Takeshi Tominaga, Masakazu Toi, Osahiko Abe, Yasuo Ohashi, Junichi Uchino, Hiroshi Hayasaka, Rikiya Abe, Masaru Izuo, Kohji Enomoto, Hiromu Watanabe, Minoru Yoshida, Tetsuo Taguchi, Hiroki Koyama, Tsuneaki Senoo, Tetsuya Toge, Yasumasa Monden, Takao Hattori, Yasuo Nomura, Keizo Sugimachi, Koichi Hirata, Hiroaki Nakazato, Shigeto Miura, Tadaoki Morimoto, Kazuaki Asaishi, Izo Kimijima, Jun Ota, Hiroshi Sonoo and Susumu Yamaguchi : The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial, International Journal of Oncology, Vol.20, No.3, 517-525, 2002. (Summary) To assess the efficacy of 5'-DFUR, an intermediate of capecitabine, for adjuvant treatment of early breast cancer, we conducted an open-labeled multi-center randomized controlled trial to compare postoperative 5'-DFUR treatment with surgery alone. We enrolled 1217 primary breast cancer patients and randomly assigned them into two treatment groups; one received six-month postoperative 5'-DFUR treatment by consecutive or intermittent administration, and the other surgery alone. Follow-up surveys were conducted once a year for all subjects simultaneously and examined their outcome/presence or absence of the cancer recurrence. The central study committee reviewed all follow-up data and judged the recurrence data to be used for the analysis. Eight-year follow-up data showed no significant differences in relapse-free and overall survival between the two groups, and 5'-DFUR treatment regimen showed an extremely high tolerance. Possible explanations are discussed for the finding of no significant survival difference between adjuvant 6-month 5'-DFUR monotherapy and surgery alone in early breast cancer. (Keyword) adjuvant therapy / breast cancer / randomized controlled trial (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11836563 ● Search Scopus @ Elsevier (PMID): 11836563 (PubMed: 11836563)
41.	Haiying Zhao, Tadaoki Morimoto, Mitsunori Sasa, Yutaka Asato and Keisuke Izumi : Cases Report of Malignant Mucocele-like Lesions, Breast Cancer, Vol.9, No.1, 86-90, 2002. (Summary) Mucocele-like lesions (MLL) of the breast have been reported as extremely rare as well as benign, but now it is believed they can be both malignant and benign. This paper describes two cases of malignant MLL, both subjected to immunohistochemical staining. Case 1: A 42-year-old woman with multiple malignant MLLs without evidence of a mass at presentation to our hospital after biopsy, but whose ultrasonogram showed small multiple hypoechoic lesions. Case 2: A 70-year-old woman, whose left breast cancer was found on routine mammography after modified radical mastectomy for right breast cancer. Pathologically, MLL with intraductal carcinoma was diagnosed. Case 1 underwent two lumpectomies in 3 years, but even now new lesions have developed. However, the patient refused to have another operation. C-erbB2 was negative in both cases. When malignant MLL is histologically of low grade, excisional biopsy is sufficient for a single MLL with intraductal carcinoma, while it may be necessary to perform a subcutaneous mastectomy for multiple lesions. (Keyword) breast cancer / MLL / Intraductal carcinoma / Immunohistochemical staining (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12196728 ● Search Scopus @ Elsevier (PMID): 12196728 (PubMed: 12196728)
42.	T tominaga, H koyama, Y Nomura, S Miura and Tadaoki Morimoto : Primary breast cancer patients treated with breast-conserving therapy and tamoxifen, --- - Do they always require radiotherapy? - ---, Clin Dru Invest, Vol.21, No.11, 775-782, 2001.
43.	古妻嘉一, 遠藤登喜子, 岩瀬拓士, 大貫幸二, 永井宏, 東野英利子, 角田博子, 大村峯夫, 増田慎三, 中谷守一 and Tadaoki Morimoto : アンケート調査によるマンモグラフィ読影講習会の精度管理[3], Journal of Japan Association of Breast Cancer Screening, Vol.10, No.3, 225-233, 2001. (Keyword) 乳がん検診 / マンモグラフィ講習会 / アンケート調査 / 講習会ランク / 効果的講習会
44.	古妻嘉一, 遠藤登喜子, 岩瀬拓士, 大貫幸二, 永井宏, 東野英里子, 角田博子, 大村峯夫, 増田慎三, 中谷守一, 福田護, 緒方晴樹, 中島康雄, 田中克浩, 園尾博司 and Tadaoki Morimoto : アンケート調査によるマンモグラフィ読影講習会の精度管理[2], Journal of Japan Association of Breast Cancer Screening, Vol.10, No.2, 165-172, 2001. (Keyword) 乳癌検診 / マンモグラフィ講習会 / アンケート調査 / 精度管理 / 講習会ランク
45.	Tadaoki Morimoto, Mitsunori Sasa, Tetsuo Yamaguchi, Hiroyuki Kondo and Yasunobu Sagara : Breast cancer screening with mammography in women aged under 50 years in Japan, Anticancer Research, Vol.20, No.5C, 3689-3694, 2000. (Summary) BACKGROUND: The effectiveness of mammographic screening in women aged over 50 years has been confirmed in the United States and Europe, but its effectiveness in women aged from 40 to 49 years remains controversial. The optimum age for effective screening of subjects for breast cancer by mammography in Japan was studied based on the results of mammographic screening. METHOD: The benefit of breast cancer screening in women was examined by stratifying the results of mammographic screening in a Tokushima trial on the basis of age: under 50 years and 50 years or older. The results of conventional screening by physical examination alone, which we performed in a Zentsuji trial, were used as the control. RESULTS: The examinees numbered 13,982 and 18,619 in mammographic screening and screening by physical examination, respectively. Breast cancer was detected in 43 and 22 patients, respectively. The detection rate of breast cancer was 0.31% by mammographic screening, which is about 3 times higher than that (0.12%) by screening using physical examination. Mammographic screening thus showed significantly higher sensitivity (93.5% vs 73.3%, p = 0.015). The proportion of stage I cancer and the absence of nodal involvement were 67.4% and 79.1% by mammographic screening, compared with 31.8% and 59% by physical examination. Our results obtained with mammographic screening were equal to or higher than the results obtained in the United States and Europe. The clinical stage of the breast cancers detected by mammographic screening in the subjects aged under 50 years was stage 0 (DCIS) in one case and stage I in 10 cases, while the group aged 50 years or older showed stage 0 in 11 cases and stage I in 19 cases. There were three cases of false-negative; two false-negative cases were aged under 50 year, while one case was aged 50 years or older. The detection rates of cancer in the group under 50 years and that of 50 years or more were 0.19% and 0.39% by mammograpic screening and 0.09% and 0.15% by the physical examination. The sensitivities in the group under 50 years and that of 50 years or more were 84.6% and 97.0% by mammographic screening and 72.7% and 73.7% by physical examination, showing no significant difference. In the results of mammograms by Wolfe's classification with respect to the age groups, the proportion of DY (dense breast) pattern decreased significantly from 3.5% to 0.2% in women of 50 years or more and from 16.6% to 2.4% in those under 50 years when the values were compared between the period from 1992 to 1995 and the period from 1998 to 1999, respectively (p < 0.0001). CONCLUSION: The above findings suggested the possible effectiveness of mammographic screening not only in women aged 50 years or more but also in those aged under 50 years, in Japan. Therefore, introduction of mammography should be considered at an early date, even for women aged from 40 to 49 years. (Keyword) breast cancer / mammograohic screening / under 50 years / early detection / screening sensitivity (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11268440 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034535057 (PubMed: 11268440, Elsevier: Scopus)
46.	Yumi Kuwamura, Tadaoki Morimoto, Ayako Tamura, Takako Ichihara, Takako Minagawa, Kanako Katai, Mari Haku, Mieko Takeuchi and Toshiko Tada : Temperature effect of a disinfectant in operative field during surgery under local anesthesia, Nursing & Health Sciences, Vol.2, No.4, 205-210, 2000. (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1442-2018.2000.00058.x (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1046/j.1442-2018.2000.00058.x (DOI: 10.1046/j.1442-2018.2000.00058.x)
47.	Ayako Tamura, Tadaoki Morimoto, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, 三木好美 and 笹三徳 : 乳房温存術および胸筋温存乳房切除術に対する新しい術後機能回復訓練実施プログラムの評価, 乳癌の臨床, Vol.1, No.6, 594-595, 2000.
48.	Yasuhiro Kaneda, Akira Fujii, Takashi Yamaoka, Tadaoki Morimoto and Isao Nagamine : Neither gynecomastia nor galactorrhea is a common side effect of neuroleptics in male patients, Neuroendocrinology Letters, Vol.21, No.6, 447-451, 2000. (Summary) OBJECTIVE: Gynecomastia is known to be a side effect of neuroleptics. The authors investigated the prevalence of gynecomastia and galactorrhea in a group of regularly neuroleptic-treated male patients. METHODS: Gynecomastia was defined as a palpable, discrete button of firm subareolar tissue measuring at least 2 cm in diameter. The subjects were 100 male patients who were taking neuroleptic treatment regularly. Each patient gave informed consent for the research involved in this study. RESULTS: (1) Palpable gynecomastia was present in 2% of the patient group, but not at all in the normal group. (2) Galactorrhea was not present in either patient or normal group. (3) The mean level of the serum prolactin in the group of patients without gynecomastia (n = 53) was significantly higher than that in the normal group (n = 35), but there was no significant difference in blood luteinizing hormone, follicle-stimulating hormone, testosterone (T), estradiol (E(2)) or T/E(2) ratio between the groups. (4) The mean level of the T/E(2) ratio in the patients with gynecomastia tended to be higher than that in the group of patients without gynecomastia. CONCLUSIONS: Overall, these results seem to indicate that (i) gynecomastia is not common in the Japanese population, and (ii) in male patients neither palpable gynecomastia nor galactorrhea is a common side effect of neuroleptics. To clarify the relation between gynecomastia and neuroleptic treatment, large prospective studies are required. (Keyword) estradiol / galactorrhea / gonadotropins / gynecomastia / neuroleptics (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11335865 ● Summary page in Scopus @ Elsevier: 2-s2.0-0033665584 (PubMed: 11335865, Elsevier: Scopus)
49.	Yuuken Oomine, Tadaoki Morimoto, Yohsuke Kinouchi, Tadamitsu Iritani, Mieko Takeuchi and Yasumasa Monden : Noninvasive Measurement of the Electrical Bioimpedance of Breast Tumors, Anticancer Research, Vol.20, No.3B, 1941-1946, 2000. (Summary) The purpose of this study was to evaluate the possibility of differential diagnosis of tumors, such as breast cancer, by measuring the mammary electrical bioimpedance via the skin surface noninvasively and by examining the relationship between the tissue structure of the breast and electrical bioimpedance. The mammary electrical bioimpedance was measured in 24 patients with breast cancer. Taking into account the measurement results and the distribution of the mammary glands and fatty tissue, a breast model with tumors was proposed. Based on this model, the distributions of the electric potential and electric field in the tissue were theoretically analyzed by the three-dimensional finite element method. In clinical cases, the Re values of the diseased breast were significantly larger than those of the contralateral healthy breast. In theoretical analysis based on the breast model, the Re value of mammary electrical bioimpedance varied due to the structure of the breast, that is, the ratio of fatty tissue to mammary gland and the presence of mammary tumors. The results of the measurement agreed with the theoretical analyses. These results suggest that differential diagnosis of breast tumors is possible by measuring the mammary electrical bioimpedance using noninvasive electrodes on the skin. (Keyword) Adipose Tissue / Breast / Breast Diseases / Breast Neoplasms / Computer Simulation / Diagnosis, Differential / Electric Impedance / Electrodiagnosis / Female / Galvanic Skin Response / Humans / Models, Theoretical (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10928131 ● Summary page in Scopus @ Elsevier: 2-s2.0-0033883417 (PubMed: 10928131, Elsevier: Scopus)
50.	Yingyan Yu, Tadaoki Morimoto, Mitsunori Sasa, Kuniyasu Okazaki, Yosuke Harada and Tsutomu Fujiwara : Human papillomavirus type 33 DNA in breast cancer in Chinese, Breast Cancer, Vol.7, No.1, 33-36, 2000. (Keyword) HPV33 / breast cancer / PCR / Chinese
51.	Yingyan Yu1, Tadaoki Morimoto, Mitsunori Sasa, Kuniyasu Okazaki, Yosuke Harada, Tsutomu Fujiwara, Yasuo Irie, Ei-ichi Takahashi, Akira Tanigami and Keisuke Izumi : HPV33 DNA in premalignant and malignant breast lesions in Chinese and Japanese populations., Anticancer Research, Vol.19, No.6B, 5057-5061, 1999. (Summary) The relationship between human papillomavirus (HPV) infection and breast cancer is controversial. In this study, paraffin-embedded tissue blocks prepared from 72 patients with benign, premalignant or malignant mammary lesions were randomly collected from the Shanghai region of China and Tokushima in Japan. DNA specimens extracted from all tissues were amplified by the polymerase chain reaction (PCR) using HPV16, 18 and 33 primers. Southern blot hybridization showed 19 cases to be positive for HPV33 DNA: The positive rate for HPV33 DNA in Chinese (41.7%) was significantly higher than in Japanese (11.1%) (P < 0.01): The positive rate for HPV33 DNA in invasive ductal carcinoma (34.1%) was higher than in benign or borderline mammary lesions (5%) (P < 0.02). There were no statistically significant difference among the relationship of the nuclear grade of breast cancers with HPV33 DNA-positivity. This is the first report of a positive correlation between HPV33 DNA and breast lesions in Chinese and Japanese populations. These results suggest that the infection by HPV33, but not HPV 16 or HPV 18, may be involved in breast hyperplastic lesions, especially breast cancer, in humans. (Keyword) Adult / Aged / Aged, 80 and over / Base Sequence / Breast Neoplasms / China / DNA Primers / DNA, Viral / Female / Humans / Japan / Middle Aged / Papillomaviridae / Polymerase Chain Reaction / Precancerous Conditions (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10697510 ● Summary page in Scopus @ Elsevier: 2-s2.0-17544382123 (PubMed: 10697510, Elsevier: Scopus)
52.	Toshiko Tada, Tadaoki Morimoto and Yamamoto Sumiko : Characteristics of the Daily Lives of Elderly Women at Various facilities for the Aged: Analysis of their ADL and Degree of Satisfaction, Nursing & Health Sciences, Vol.1, No.1, 13-18, 1999. (Keyword) elderly / satisfaction / care
53.	Hitoshi Ikushima, Yoshihiro Takegawa, Hiroaki Yasuda, Yumi Makimoto, Kenji Matsuzaki, Kenichi Kashihara, Junji Ueno, Mitsunori Sasa, Tadaoki Morimoto and Hiromu Nishitani : Radiation Complications Following Breast Conserving Therapy, Breast Cancer, Vol.5, No.4, 395-400, 1998.
54.	Hitoshi Miki, Hiroyuki Inoue, Kansei Komaki, Tadashi Uyama, Tadaoki Morimoto and Yasumasa Monden : Value of mass screening for thyroid cancer, World Journal of Surgery, Vol.22, No.1, 99-102, 1998. (Summary) This study aims to clarify the presently uncertain value of mass screening for thyroid cancer, which has been performed by physical examination along with mass screening for breast cancer in Zentsuji, Japan since 1983. Among 18,619 subjects, 36 individuals with thyroid cancer (0.19%) were found. The detection rate was 0.40% at the initial screening and 0.10% during subsequent periodic screening. All thyroid cancers were confirmed histologically as well differentiated carcinoma. The tumor size in the mass-screening group (14 +/- 6 mm) was significantly smaller than in patients presenting at an outpatient clinic during the same period (19 +/- 13 mm) (p < 0.05). The incidence of nodal metastases in the mass-screening group (38%) was significantly lower than in the outpatient group (68%) (p < 0.05). Thus mass screening seemed to find thyroid cancers in a relatively early stage. Mass screening for thyroid cancer was economic in this instance because it was performed together with screening for other cancers, such as breast cancer. Thyroid cancer screening required less than one additional minute per subject. The ultimate aim of mass screening is to reduce mortality. No improvement in prognosis from enforced mass screening for thyroid cancer was detected in this study. It cannot be demonstrated that there is sufficient value of mass screening for thyroid cancer to perform it independently despite early cancer detection. (Keyword) Adult / Female / Humans / Male / Mass Screening / Middle Aged / Thyroid Neoplasms (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9465769 ● Search Scopus @ Elsevier (PMID): 9465769 (PubMed: 9465769)
55.	Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Shigeru Ohyama : Fast in vivo measurements of local tissue impedances using needle electrodes, Medical and Biological Engineering and Computing, Vol.35, No.5, 486-492, 1997. (Summary) The objective of the research is to show an in vivo, fast method of measurement of local tissue bio-impedance in the beta dispersion region (0-200 kHz). A needle electrode is used for the purpose. The performances with respect to circuits, electrodes, measurement area and electrical representations are evaluated. A measurement example is shown, and the electrical representations are discussed and compared using it. The method discussed, although invasive, is considered to be useful for local tissue diagnoses concerning structures and physiological functions. (Keyword) Bio-impedance / Tissue / Needle electrode / Pulse response method / measurement / Equivalent circuit (Link to Publication Site) ● Publication site (DOI): 10.1007/BF02525528 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9374052 ● Summary page in Scopus @ Elsevier: 2-s2.0-0031237609 (DOI: 10.1007/BF02525528, PubMed: 9374052, Elsevier: Scopus)
56.	Tadaoki Morimoto, Sasa Mitsunori, Tetsuo Yamaguchi, Hiroyuki Kondo, Yasunobu Sagara, Yumi Kuwamura, Sumiko Yamamoto and Toshiko Tada : Effectiveness of mammographic screening for brest cancer in women aged over 50 years in Japan, Japanese Journal of Cancer Research, Vol.88, No.8, 778-784, 1997. (Keyword) breast cancer / Mammographic screening / Early detection / Screening sensitivity / Effectiveness
57.	H Blaszyk, A Hartmann, Y Tamura, S Saitoh, JM Cunningham, RM McGovern, JJ Schroeder, DJ Schaid, K Ii, Y Monden, Tadaoki Morimoto, Kansei Komaki, M Sasa, K Hirata, M Okazaki, JS Kovach and SS Sommer : Molecular epidemiology of breast cancers in northern and southern Japan: the frequency, clustering, and patterns of p53 gene mutations differ among these two low-risk populations, Oncogene, Vol.13, No.10, 2159-2166, 1996. (Summary) Comparison of acquired mutations in the p53 tumor suppressor gene can illuminate factors contributing to carcinogenesis among cancer cohorts. Japan has an ethnically homogeneous population with a low incidence of breast cancer. Previously we reported an unusual frequency, allelic status, and clustering of mutations in breast cancers from the northern part of the main Japanese island. To extend these findings, exons 2-11 and adjacent intronic sequences were analysed in tumors of women from northern (Hokkaido) and southern (Tokushima) Japan. The frequency of breast cancers with p53 gene mutations in the Hokkaido group is the highest reported (81%) while that in Tokushima (28%) is similar to most other populations. Thirteen of the 19 mutations (68.4%) in the Hokkaido cohort were heterozygous, an unusually high frequency for p53 mutations in any tumor type. There were three missense mutations at codon 175, a known hotspot for alterations in the p53 gene, and three missense mutations at codon 179, a rare site for p53 changes. In addition, the patterns of p53 gene mutation differed between the two Japanese cohorts (P=0.04). The multiple differences in acquired p53 mutations suggest unsuspected biological differences among breast cancers in northern and southern Japan. In addition, the high frequency of p53 mutations in breast cancers from Hokkaido predicted a poorer prognosis for this population which was confirmed on examination of mortality data. (Keyword) Japan / molecular epidemiology / p53 / breast cancer (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8950983 ● Search Scopus @ Elsevier (PMID): 8950983 (PubMed: 8950983)
58.	Takashi Yamakawa, Mitsuaki Shinotoh, Toshikatsu Taniki, Osamu Yasuda, Masaki Hamagaki, Kan Kondoh, Akiyosi Yamamoto, Satoshi Mumoto, Sueyoshi Itoh, Mitsunori Sasa and Tadaoki Morimoto : Ductal Carcinoma In Situ of the Breast: Is Breast Conserving Treatment Feasible?, Breast Cancer, Vol.3, No.2, 119-123, 1996. (Keyword) breast cancer / Ductal carcinoma in siru / Extention of cancer / Mammography / Breast conserving treatment
59.	Tadaoki Morimoto, Michio Ogawa, Kunzo Orita, Keizo Sugimachi, Tetsuya Toge, Kiyohiko Dohi, Yasuo Nomura, Yasumasa Monden and Nobuya Ogawa : Postoperative adjuvant randomized trial comparing chemoendocrine therapy, chemotherapy and immunotherapy for patients with stageII breast cancer, --- 5-year results from The Nishinihon cooperative study group of Adjuvant Chemoendocrine Therapy for Breast Cancer (ACETBC) of Japan ---, European Journal of Cancer, Vol.32A, No.2, 235-242, 1996. (Summary) Between 1985 and 1988, the effect of using ftorafur (FT) or PSK (an immunotherapy agent) in combination with the conventional postoperative adjuvant therapy using mitomycin (MMC) plus tamoxifen (TAM) was assessed in stage II, oestrogen receptor-positive (ER+) breast cancer patients. Furthermore, in ER- breast cancer stage II patients, the effects of postoperative adjuvant therapy using MMC plus FT were compared with the effects of postoperative adjuvant therapy using MMC plus PSK. Patients had primary stage II breast cancer and had undergone total mastectomy plus axillary dissection or more radical surgery. On the day of surgery, MMC (13 mg/m2) was administered intravenously. Then, ER+ patients received one of three regimens of drug therapy, starting 2 weeks after surgery: regimen A (daily oral treatment with 30 mg of TAM), regimen B (daily oral treatment with 30 mg of TAM and 600 mg of FT) or regimen C (daily oral treatment with 30 mg of TAM and 3 g of PSK) [corrected]. ER- patients received either regimen D (daily oral treatment with 600 mg of FT) or regimen E (daily oral treatment with 3 g of PSK), starting 2 weeks after surgery. Of the 540 ER+ patients registered, 525 were evaluated. The 5-year overall survival rate for ER+ patients was higher for patients who received regimen B (94.2%) than for those who received regimen A (86.9%) or regimen C (89.9%) (P = 0.063). The 5-year relapse-free survival rate was higher for regimen B (88.9%) than for regimen A (78.6%) and regimen C (77.2%) (P = 0.010). Stratified analysis revealed better results with the FT-combined therapy in patients positive for lymph node metastasis and premenopausal patients. These results indicate the effectiveness of using FT in combination with TAM. Of the 376 ER- patients registered, 364 were evaluated. The 5-year overall and relapse-free survival rate for ER- patients did not differ significantly between patients who received regimen D and those who received regimen E. (Keyword) Adult / Aged / Antimetabolites, Antineoplastic / Antineoplastic Combined Chemotherapy Protocols / Breast Neoplasms / Chemotherapy, Adjuvant / Disease-Free Survival / Drug Administration Schedule / Female / Follow-Up Studies / Humans / Immunologic Factors / Middle Aged / Mitomycin / Neoplasm Metastasis / Proteoglycans / Survival Rate / Tamoxifen / Tegafur (Link to Publication Site) ● Publication site (DOI): 10.1016/0959-8049(95)00579-X (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8664034 ● Search Scopus @ Elsevier (PMID): 8664034 ● Search Scopus @ Elsevier (DOI): 10.1016/0959-8049(95)00579-X (DOI: 10.1016/0959-8049(95)00579-X, PubMed: 8664034)
60.	Takashi Yamakawa, Mitsuaki Shinotoh, Toshikatsu Taniki, Osamu Yasuda, Masaki Hamagaki, Kan Kondoh, Akiyosi Yamamoto, Satoshi Mumoto, Sueyoshi Itoh, Mitsunori Sasa and Tadaoki Morimoto : carcinoma in situ of the breast, --- Is breast conserving treatmart feasible ? ---, Breast Cancer, Vol.3, No.2, 119-123, 1996.
61.	Takashi Tanaka, Tadaoki Morimoto, Yohsuke Kinouchi, Tadamitsu Iritani and Yasumasa Monden : An experimental study of conductive heating using a concentric double-electrode applicator, Research in Experimental Medicine, Vol.195, No.5, 255-264, 1995.
62.	Yasunori Konishi, Tadaoki Morimoto, Yohsuke Kinouchi, Tadamitsu Iritani and Yasumasa Monden : Electrical properties of extracted rat liver tissue, Research in Experimental Medicine, Vol.195, No.4, 183-192, 1995.
63.	Takashi Yamakawa, Tadaoki Morimoto, Mitsunori Sasa, Satoshi Numoto and Yasumasa Monden : High positive rate of pS2 expression in forefront intraductal cancerous area in breast cancer, Japanese Journal of Cancer Research, Vol.86, No.11, 1035-1040, 1995. (Keyword) breast cancer / pS2protein / Hormone dependency / Estrogen receptor / Breast conserving treatment
64.	Kansei Komaki, Yoshitaka Kamamura, Yuken Ohmime, Mitsunori Sasa, Hiroyuki Inoue, Katsuhiro Tanaka, Tadashi Uyama, Tadaoki Morimoto and Yasumasa Monden : Difference in thymidylate synthetase activity in involved nodes compared with primary tumor in breast cancer patients, Breast Cancer, Vol.35, No.2, 157-162, 1995. (Keyword) human breast tissue / breast cancer / thymidylate synthetase / nodal metastasis / mitosis
65.	Tadaoki Morimoto, Mitsunori Sasa, Kunio Ii, Hideo Tsuzuki, Yoshitaka Kamamura, Kansei Komaki, Tadashi Uyama and Yasumasa Monden : A Malignant Phyllodes Tumor of the Breast in a 6-Year Old Girl, Breast Cancer, Vol.2, No.1, 71-75, 1995. (Keyword) breast / estrogen receptor / phyllodes tumor / PCNA
66.	Tadaoki Morimoto, Mitsunori Sasa, Tetsuo Yamaguchi, Kunihiko Harada and Yasunobu Sagara : A Comparison of Mass Screening for Breast Cancer Using Mammography and Physical Examination Alone in Japan, Breast Cancer, Vol.2, No.1, 19-25, 1995. (Keyword) mass screening / breast cancer / early detection / mammography
67.	Tadaoki Morimoto, Mitsunori Sasa, Tetsuo Yamaguchi, Kunihiko Harada and Yasunobu Sagara : High detection rate of breast cancer by mass screening using mammography in Japan, Japanese Journal of Cancer Research, Vol.85, No.12, 1193-1195, 1994. (Keyword) mass screening / breast cancer / mammmography / early detection / detection rate
68.	Suguru Kimura, Tadaoki Morimoto, Tadashi Uyama, Yasumasa Monden, Yohsuke Kinouchi and Tadamitsu Iritani : Application of electrical impedance analysis for diagnosis of a pulmonary mass, Chest, Vol.105, No.6, 1679-1682, 1994.
69.	Mitsunori Sasa, Kazuya Kondo, Kansei Komaki, Tadaoki Morimoto and Yasumasa Monden : p53 alteration correlates with negative ER, negative PgR, and high histologic grade in breast cancer., Journal of Surgical Oncology, Vol.56, No.1, 46-50, 1994. (Summary) Seventy tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the RT-PCR-SSCP method. Sixty-five samples (92.9%) were investigated in the regions of codons 101-200 and 201-300. In total, 16 samples (24.6%) showed p53 gene alteration. We found that p53 gene alteration showed a correlation with (1) a negative ER status, (2) a negative PgR status, and (3) a high histologic grade (especially numerous mitotic figures) of the tumor. However, we found no correlation between p53 gene alteration and the lymph node status or clinical stage. Thus, p53 gene alteration in breast cancer may occur in highly malignant breast cancer other than advanced clinical stage cancer or node-positive cancer. (Keyword) Adult / Aged / Base Sequence / Breast Neoplasms / Female / Genes, p53 / Humans / Middle Aged / Molecular Sequence Data / Mutation / Polymerase Chain Reaction / Polymorphism, Genetic / Receptors, Estrogen / Receptors, Progesterone (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8176940 ● Search Scopus @ Elsevier (PMID): 8176940 (PubMed: 8176940)
70.	Mitsunori Sasa, Kansei Komaki, Tadaoki Morimoto, Toshiaki Mori, Hitoshi Miki, Tadashi Uyama and Yasumasa Monden : Significant Correlation between the Presence of Type W Collagen in the Duct Wall and the Development of Wide Intraductal Cancerous Extension in Breast Cancer, Breast Cancer, Vol.1, No.1, 31-36, 1994. (Keyword) breast cancer / EIC / PCNA / Type collagen / Wide intraductal cancerous extension
71.	Tadaoki Morimoto, Yasumasa Monden, Shigemitsu Takashima, Sueyoshi Itoh, Takashi Kimura, Hiroyuki Yamamoto, Muneo Kitamura, Kozo Inui, Naoomi Tanaka, Takashi Nagano, Noriaki Fuzishima, Junji Yanada, Masaki Tsuruno and Kansei Komaki : Five-year results of a randomized clinical trial comparing modified radical mastectomy and extended radical mastectomy for stage II breast cancer, Surgery Today, Vol.24, No.3, 210-214, 1994. (Keyword) breast cancer / stage / randomized study / modified radical mastectomy / extended radical mastectomy
72.	Mitsunori Sasa, Kansei Komaki, Hideo Tsuzuki, Yoshitake Kamamura, Toshiaki Mori, Hitoshi Miki, Tadashi Uyama, Tadaoki Morimoto and Yasumasa Monden : Tumor progression accompanied by increase in proliferation rate in breast cancer: a preliminary report, Journal of Surgical Oncology, Vol.54, No.4, 255-259, 1993. (Keyword) breast cancer / intraductal cancer / involved node / primary tumor / proliferation rate
73.	M Sasa, Kazuya Kondo, K Komaki, T Uyama, Tadaoki Morimoto and Yasumasa Monden : Frequency of spontaneous p53 mutations (CpG site) in breast cancer in Japan., Breast Cancer Research and Treatment, Vol.27, No.3, 247-252, 1993. (Summary) Sixty-five tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the reverse transcription-polymerase chain reaction-single strand conformation polymorphism (RT-PCR-SSCP) method and sequencing analysis. In total, 16 samples (24.6%) showed p53 gene alteration. Sixteen of these alterations were evaluated by sequencing analysis, and 15 showed missense point mutations while one showed a 9-base pair deletion. In the 15 point mutations, G:C to A:T transitions constituted the majority (53%), and five tumors (33%) had a transition at the CpG site, which are mutational patterns not commonly found in breast tumors from Europe and America. On the other hand, there were no G:C to T:A transversions in our cases, which were frequently observed transversions in Europe and America. These p53 mutation patterns in breast cancer in Japan are not similar to those in Europe and America reported by Hollstein et al. and Coles et al.. These findings suggest that there are some differences between mechanisms of breast cancer in Japan and in Europe and America. (Keyword) Adult / Aged / Base Sequence / Breast Neoplasms / Female / Genes, p53 / Humans / Middle Aged / Molecular Sequence Data / Mutation / Polymerase Chain Reaction (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8312582 ● Search Scopus @ Elsevier (PMID): 8312582 (PubMed: 8312582)
74.	Hiroyuki Inoue, Kazushi Oshimo, Hitoshi Miki, Muneo Kawano, Kansei Komaki, Yasumasa Monden, Tadaoki Morimoto and Masaru Tsuyuguchi : Immunohistochemical study of estrogen receptor and estradiol on papillary thyroid carcinoma in young patients, Journal of Surgical Oncology, Vol.53, No.4, 226-230, 1993. (Keyword) thyroid cancer / estrogen receptor / estradiol / young patient / childhood / ER-D5
75.	Hitoshi Miki, Kazushi Oshimo, Hiroyuki Inoue, Muneo Kawano, Katsuhiro Tanaka, Kansei Komaki, Tadashi Uyama, Yasumasa Monden and Tadaoki Morimoto : Incidence of ultrasonographically-detected thyroid nodules in healthy adults, The Tokushima Journal of Experimental Medicine, Vol.40, No.1-2, 43-46, 1993. (Keyword) thyroid disease / ultrasonography / goiter
76.	Takao Yokoe, Tsunehiro Ishida, Suketami Tominaga, Tetsuo Kuroishi, Tadaoki Morimoto, Hideya Tashiro, Sueyoshi Itoh, Rikiya Abe, Jun Ota, Toshio Horino, Tetsuo Taguchi, Kazuyoshi Honda, Michizou Sasakawa, Yoshitomo Kashiki, Satoru Yamamoto, Kohji Enomoto, Masami Ogita, Koichi Yoshida, Choichiro Kido, Mamoru Fukuda, Hiromu Watanabe and Masaru Izuo : Effect of mass screening for breast cancer from the aspect of psychosocial assessment of the quality of life, Japanese Journal of Cancer Research, Vol.84, No.4, 365-370, 1993. (Keyword) breast cancer / mass screening / quality of life / psychosocial assessment
77.	Tadaoki Morimoto, Suguru Kimura, Yasunori Konishi, Kansei Komaki, Tadashi Uyama, Yasumasa Monden, Yohsuke Kinouchi and Tadamitsu Iritani : A study of the electrical bioimpedance of tumors, Journal of Investigative Surgery, Vol.6, No.1, 25-32, 1993. (Summary) A new system of impedance measurement over a frequency range of 0 to 200 kHz was developed by a three-electrode method. In this study, the electrical impedances of various tumors were measured in vivo in 54 patients with breast disease (31 breast cancers, 13 fibroadenomas, and 10 fibrocystic diseases) and 57 patients with pulmonary disease (44 lung cancers, 5 metastatic pulmonary tumors, 4 pulmonary tuberculoses, and 4 organized pneumonias). On the basis of those impedance measurements and the equivalent circuits in vivo, we calculated the extracellular resistance (Re), intracellular fluid resistance (Ri), and cell membrane capacitance (Cm) in tissues, all of which were compared among the various diseases. It was found that Re and Ri were significantly higher in breast cancers than in benign tumors and normal breast tissues and that Cm was significantly lower in breast cancers than in other tissues. On the other hand, Re and Ri were significantly higher, and Cm was significantly lower, in normal lung tissues than in pulmonary masses. Re and Ri were significantly higher, and Cm was significantly lower, in malignant tumors than in organized pneumonias. The results showed that these parameters (Re, Ri, and Cm) exhibit significant differences among various tissues and tumors, suggesting possible applications in tumor diagnosis. (Keyword) breast tumor / diagnostic modality / electrical bioimpedance / in vivo / lung tumor (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8452822 ● Summary page in Scopus @ Elsevier: 2-s2.0-0027410236 (PubMed: 8452822, Elsevier: Scopus)
78.	Tadaoki Morimoto, Takashi Tanaka, Kansei Komaki, Mitsunori Sasa, Yasumasa Monden, Hisajiro Kumagai and Hisashi Otsuka : The coexistence of lobular carcinoma in a fibroadenoma with a malignant phyllodes tumor in the opposite breast: report of a case, Surgery Today, Vol.23, No.7, 656-660, 1993. (Keyword) breast tumor / lobular carcinoma / fibroadenoma / phyllodes tumor
79.	Tadaoki Morimoto, Kuniyasu Okazaki, Kansei Komaki, Mitsunori Sasa, Toshiaki Mori, Hideo Tsuzuki, Yoshitaka Kamamura, Hitoshi Miki and Yasumasa Monden : Cancerous residue in breast-conserving surgery, Journal of Surgical Oncology, Vol.52, No.2, 71-76, 1993. (Keyword) breast cancer / breast-conserving treatment / local extension / cancerous residue
80.	Tadaoki Morimoto, Kansei Komaki, Toshiaki Mori, Mitsunori Sasa, Hitoshi Miki, Hiroyuki Inoue, Yasumasa Monden and Hideki Nakanishi : Juvenile gigantomastia: report of a case, Surgery Today, Vol.23, No.3, 260-264, 1993. (Keyword) juvenile gigantomastia / virginal macromastia / juvenile breast hypertrophy / hormone receptors
81.	Tadaoki Morimoto, Kansei Komaki, Toshiaki Mori, Mitsunori Sasa, Kazushi Oshimo, Hitoshi Miki, Yasumasa Monden, Kozo Inui, Nobuo Saoyama and Hiiru Yoshida : The quality of mass screening for breast cancer by physical examination, Surgery Today, Vol.23, No.3, 200-204, 1993. (Keyword) breast cancer / mass screening / physical examination / sensitivity / specificity
82.	Tadaoki Morimoto, Kansei Komaki, Kazushi Oshimo, Hitoshi Miki, Mitsunori Sasa, Toshiaki Mori, Hideo Tsuzuki, Yoshitaka Kamamura and Yasumasa Monden : The characteristics of interval breast cancer in mass screening, The Tokushima Journal of Experimental Medicine, Vol.39, No.3-4, 109-116, 1992. (Keyword) breast cancer / Mass screening / Interval cancer / Histological grading / Tumor doubling time
83.	Takesada Mori, Hideo Inaji, Hiroki Koyama, Rikiya Abe, Mitsuhiro Nihei, Masaru Izuo, Tetsuo Ogawa, Koji Enomoto, Hironobu Sato, Fujio Kasumi, Goi Sakamoto, Masujiro Makita, Shigeto Miura, Osamu Kojima, Keisuke Miyauchi, Akira Wada, Eiji Yayoi, Yuichi Takatsuka, Tadaoki Morimoto, Kansei Komaki, Yasuhiko Miyauchi, Michitsugu Sato and Takashi Kudo : Evaluation of an improved dot-immunobinding assay for carcinoembryonic antigen determination in nipple discharge in early breast cancer: results of a multicenter study, Japanese Journal of Clinical Oncology, Vol.22, No.6, 371-376, 1992. (Summary) We have previously reported carcinoembryonic antigen (CEA) measurement in nipple discharge to be a useful adjunct in the diagnosis of non-palpable breast cancer. We have now developed a "microdot-immunobinding assay" using a specially constructed device to screen efficiently large numbers of patients with nipple discharge for non-palpable breast cancer. The method is as follows: a sample of nipple discharge is placed on a solid phase monoclonal anti-CEA antibody and, if CEA is present in the discharge, it will be detected by a second monoclonal anti-CEA antibody conjugated with alkaline phosphatase. The use of bromochloroindolyl phosphate as a chromogen results in a stable color reaction that can be semiquantitatively analyzed with the naked eye. CEA levels determined by this microdot assay correlated well with those determined using the earlier Elmotec assay. To determine the accuracy of the method, a collaborative study involving 11 institutes in Japan was organized. The CEA levels in nipple discharges from 77 patients undergoing surgery, 44 of whom were diagnosed as having breast cancer, were assayed. The results were that 17 of the 23 patients with palpable breast cancer, and 16 of the 21 patients with non-palpable breast cancer exhibited CEA values > 400 ng/ml, a cut-off value determined in a previous study. The overall accuracy (78%) of this test for diagnosing non-palpable breast cancer was higher than that obtained from ductography or cytology. The system may thus be of use in the screening of early breast cancer. (Keyword) nipple discharge / carcinoembryonic antigen (CEA) / breast cancer / dot-immunobinding assay / mass screening (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1291755 ● Search Scopus @ Elsevier (PMID): 1291755 (PubMed: 1291755)
84.	Masakazu Toi, Takao Hattori, Masanobu Akazi, Kiyoshi Inokuchi, Kunzo Orita, Keizo Sugimachi, Kiyohiko Dohi, Yasuo Nomura, Yasumasa Monden, Yuzo Hamada, Tadaoki Morimoto and Nobuya Ogawa : Randomized adjuvant trial to evaluate the addition of tamoxifen and PSK to chemotherapy in patients with primary breast cancer. 5-Year results from the Nishi-Nippon Group of the Adjuvant Chemoendocrine Therapy for Breast Cancer Organization, Cancer, Vol.70, No.10, 2475-2483, 1992. (Keyword) breast cancer / adjuvant therapy / tamoxifen / PSK / ftorafur / mitomycin C
85.	Hitoshi Miki, Kazushi Oshimo, Hiroyuki Inoue, Muneo Kawano, Tadaoki Morimoto and Yasumasa Monden : Estimated weight of the residual parathyroid gland after parathyroidectomy Surgery using plasma levels of parathyroid hormone, Surgery Today, Vol.22, No.3, 196-200, 1992. (Keyword) secondary hyperparathyroidism / weight of the parathyroid / parathyroid hormone
86.	Tetsuo Kuroishi, Suketami Tominaga, Jun Ota, Toshio Horino, Tetsuo Taguchi, Tsunehiro Ishida, Takao Yokoe, Masaru Izuo, Masami Ogita, Sueyoshi Itoh, Rikiya Abe, Koichi Yoshida, Tadaoki Morimoto, Kohji Enomoto, Hideya Tashiro, Yoshitomo Kashiki, Satoru Yamamoto, Choichiro Kido, Kazuyoshi Honda, Michizou Sasakawa, Mamoru Fukuda and Hiromu Watanabe : The effect of breast self-examination on early detection and survival, Japanese Journal of Cancer Research, Vol.83, No.4, 344-350, 1992. (Keyword) breast self-examination / breast cancer / survival / multivariate analysis
87.	Hitoshi Miki, Kazushi Oshimo, Hiroyuki Inoue, Muneo Kawano, Tadaoki Morimoto, Yasumasa Monden, Yosuke Yamamoto and Seizo Kita : Thyroid carcinoma in patients with secondary hyperparathyroidism, Journal of Surgical Oncology, Vol.49, No.3, 168-171, 1992. (Keyword) thyroid cancer / hemodialysis / parathyroidectomy / parathyroid hormone
88.	Yasuo Nomura, Shigeto Miura, Hiroki Koyama, Kohji Enomoto, Fujio Kasumi, Hiroshi Yamamoto, Masahara Kimura, Takeshi Tominaga, Hirokazu Iino, Tadaoki Morimoto and Hideya Tashiro : Relative effect of steroid hormone receptors on the prognosis of patients with operable breast cancer. A univariate and multivariate analysis of 3089 Japanese patients with breast cancer from the Study Group for the Japanese Breast Cancer Society on Hormone Receptors and Prognosis in Breast Cancer, Cancer, Vol.69, No.1, 153-164, 1992.
89.	Masaaki Kosaka, Nobuko Tsuchihashi, Makoto Takishita, Yoshiyuki Miyamoto, Kazuto Okagawa, Tetsuya Gotoh, Shiro Saito, Kansei Komaki, Tadaoki Morimoto and Toshiaki Sano : Primary adult T-cell lymphoma of the breast, Acta haematologica, Vol.87, No.4, 202-205, 1992. (Keyword) adult T-cell lymphoma / breast / extranodal lymphoma
90.	Kansei Komaki, Tadaoki Morimoto, Toshiaki Mori, Mitsunori Sasa, Kazushi Oshimo, Yasumasa Monden, Takanori Hirose and Kazuo Hizawa : A rare case of fibroadenoma in a tubular adenoma of the breast, Surgery Today, Vol.22, No.2, 163-165, 1992. (Keyword) tubular adenoma / fibroadenoma / breast adenoma
91.	Toshiaki Mori, Tadaoki Morimoto, Kansei Komaki and Yasumasa Monden : Comparison of estrogen receptor and epidermal growth factor receptor content of primary and involved nodes in human breast cancer, Cancer, Vol.68, No.3, 532-537, 1991.
92.	Kansei Komaki, Toshiaki Mori, Tadaoki Morimoto, Mitsunori Sasa, Yasumasa Monden and Kunio Ii : Correlation between estrogen receptor status and histological malignancy in human breast cancer, Journal of Surgical Oncology, Vol.46, No.3, 185-189, 1991. (Keyword) immunocytochemical assay / histological differentiation / age / staining intensity index
93.	Kansei Komaki, Goi Sakamoto, Haruo Sugano, Fujio Kasumi, Susumu Watanabe, Itsumasa Nishi, Tadaoki Morimoto and Yasumasa Monden : The morphological feature of mucus leakage appearing in low papillary carcinoma of the breast, Human Pathology, Vol.22, No.3, 231-236, 1991. (Summary) This report summarizes the clinicopathologic findings in 11 cases of low papillary carcinoma of the breast accompanied by the morphologic feature of mucus leakage into the mammary stroma. These cases were characterized by two morphologic findings. First, abundant mucus produced by the tumor cells filled the intraductal spaces where neoplastic epithelium formed very low papillary projections, ie, a feature of mucinous-producing low papillary carcinoma in situ. Second, there was expansive leakage of mucus into the mammary stroma occasionally accompanied by a few epithelial cells. All the cases showed a high level of mucus production and contained no elements of invasive ductal carcinoma or ordinary invasive mucinous carcinoma. These cases have no evidence of direct invasion of the mammary stroma by malignant cells. The average age of the 11 patients was 41 years. Foci of microcalcification were seen in some tumors (seven cases; 64%). There were no cases with lymph node metastases. All the patients underwent mastectomy with no adjuvant therapy, and they are currently alive and well. (Keyword) Adenocarcinoma, Mucinous / Adult / Breast / Breast Neoplasms / Carcinoma, Papillary / Epithelium / Female / Humans / Middle Aged / Mucus (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1848526 ● Search Scopus @ Elsevier (PMID): 1848526 (PubMed: 1848526)
94.	Tetsuo Kuroishi, Suketami Tominaga, Jun Ota, Toshio Horino, Tetsuo Taguchi, Tsunehiro Ishida, Takao Yokoe, Masaru Izuo, Masami Ogita, Sueyoshi Itoh, Rikiya Abe, Koichi Yoshida, Tadaoki Morimoto, Kohji Enomoto, Hideya Tashiro, Yoshitomo Kashiki, Choichiro Kido, Kazuyosi Honda, Michizou Sasakawa, Mamoru Fukuda and Hiromu Watanabe : The effect of mass screening for breast cancer: results of a multivariate analysis, Japanese Journal of Cancer Research, Vol.82, No.1, 27-32, 1991. (Keyword) breast cancer screening / matched paer analysis / multivariate analysis / prognosis / Life-prolonging effect
95.	Koichi Yoshida, Rikiya Abe, Sueyoshi Itoh, Tetsuo Taguchi, Jun Ota, Tadaoki Morimoto, Tsunehiro Ishida, Hideya Tashiro, Masami Ogita, Choichiro Kido, Yoshitomo Kashiki, Tetsuo Kuroishi and Suketami Tominaga : Comparisons of interval breast cancers with other breast cancers detected through mass screening and in outpatient clinics in Japan, Japanese Journal of Clinical Oncology, Vol.20, No.4, 374-379, 1990. (Summary) In a nation-wide collaborative study on mass screening for breast cancer, we collected 152 cases of interval breast cancer diagnosed at 35 hospitals or clinics distributed throughout Japan. The definition of interval breast cancer used in the present study is "breast cancer cases which were diagnosed as having 'no malignant findings' in a previous screening for breast cancer but subsequently diagnosed as 'breast cancer' at a hospital or medical clinic within two years of the previous screening." The clinical stages and prognoses of these interval cancer were analyzed and compared with those of other breast cancers detected through mass screening and in outpatient clinics. In the clinical staging of interval breast cancer, Tis (non infiltrating cancer) accounted for only 2.1%, compared to 8.0% in cases detected through mass screening. At stage I 43.4% were interval breast cancers compared to 32.9% breast cancers detected through mass screening and 25.4% diagnosed in outpatient clinics. The stage differences between interval breast cancers and breast cancers detected through mass screening were not statistically significant. Five-year survival rates were 85.6% for interval breast cancers, 91.7% for breast cancers detected through mass screening and 84.7% for breast cancers diagnosed in outpatient clinics. Ten-year survival rates were 75.9, 80.5 and 78.1%, respectively, suggesting the interval breast cancer cases to show a similar prognosis to that of breast cancer cases diagnosed in outpatient clinics. The differences in five- and 10-year survival rates among the three groups were not statistically significant. From the present study we were not able to confirm the general belief of interval cancer being more aggressive in nature and showing a poorer prognosis than cancer detected through periodic screening. The reasons for this are discussed. (Keyword) breast cancer / mass screening / interval breast cancer / clinical stage / prognosis (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 2283721 ● Search Scopus @ Elsevier (PMID): 2283721 (PubMed: 2283721)
96.	Tadaoki Morimoto, Hiroyuki Yamamoto, Kansei Komaki, Yasunori Konishi, Takashi Tanaka, Takashi Yamakawa, Toshiaki Mori, Mitsunori Sasa and Monden Yasumasa : Chemoendocrine therapy in DMBA-induced rat mammary carcinoma, The Tokushima Journal of Experimental Medicine, Vol.37, No.3-4, 59-68, 1990. (Keyword) DMBA-induced rat mammary carcinoma / 5-fluorouracil / tamoxifen / Rat
97.	Hitoshi Miki, Kazushi Oshimo, Hiroyuki Inoue, Tadaoki Morimoto and Yasumasa Monden : Sex hormone receptors in human thyroid tissues, Cancer, Vol.66, No.8, 1759-1762, 1990.
98.	Tadaoki Morimoto, Kansei Komaki, Takashi Yanakawa, Takashi Tanaka, Yuken Oomine, Yasunori Konishi, Toshiaki Mori and Yasumasa Monden : Cancer of the male breast, Journal of Surgical Oncology, Vol.44, No.3, 180-184, 1990. (Keyword) histological malignancy / hormone receptor
99.	Tetsuo Kuroishi, Suketami Tominaga, Tadaoki Morimoto, Hideya Tashiro, Sueyoshi Itoh, Hiromu Watanabe, Mamoru Fukuda, Jun Ota, Tosio Horino, Tsunehiro Ishida, Takao Yokoe, Koji Enomoto, Yoshitomo Kashiki and Masami Ogita : Tumor growth rate and prognosis of breast cancer mainly detected by mass screening, Japanese Journal of Cancer Research, Vol.81, No.5, 454-462, 1990. (Keyword) breast cancer / Natural history / Tumor growth rate / Prognosis / Doubling time
100.	Tadaoki Morimoto, Yosuke Kinouchi, Tadamitsu Iritani, Suguru Kimura, Yasunori Konishi, Nanretsu Mitsuyama, Kansei Komaki and Yasumasa Monden : Measurement of the electrical bio-impedance of breast tumors, European surgical research, Vol.22, No.2, 86-92, 1990. (Keyword) Electrical bio-impedance / Breast tumor / Diagnostic modality / Measurement in vivo
101.	Jun Ohta, Toshio Horino, Tetsuo Taguchi, Tsunehiro Ishida, Masaru lzuo, Masami Ogita, Rikiya Abe, Hiromu Watanahe, Tadaoki Morimoto, Sueyoshi Itoh, Hideya Tashiro, Koichi Yoshida, Kazuyoshi Honda, Michizou Sasakawa, Koji Enomoto, Yoshitomo Kashiki, Choichiro Kido, Tefsu Kuroishi and Suketani Tominaga : Mass screening for breast cancer: comparison of the clinical stages and prognosis of breast cancer detected by mass screening and in out-patient clinics, Japanese Journal of Cancer Research, Vol.80, No.11, 1028-1034, 1989. (Keyword) breast cancer / Mass screening / early detection / matched pair analysis / breast self-examination
102.	Yasumasa Monden, Tadaoki Morimoto, Toshikatsu Taniki, Tadashi Uyana and Suguru Kimura : Flexible bronchoscopy for foreign body in airway, The Tokushima Journal of Experimental Medicine, Vol.36, No.1-2, 35-39, 1989. (Keyword) foreign body / airway / flexible bronchoscopy / children / Fogarty catheter / ventilation
103.	Tadaoki Morimoto, Kansei Komaki, Hiroyuki Yamamoto, Takashi Yamakawa, Takashi Tanaka, Hiroshi Sonoo and Yasumasa Monden : Prognostic value of hormone receptors in breast cancer, Journal of Surgical Oncology, Vol.39, No.2, 101-107, 1988. (Keyword) breast cancer / estrogen receptor / prognostic factor
104.	Tadashi Uyama, Yasumasa Monden, Kunihiko Harada, Suguru Kiuura, Tadaoki Morimoto, Kazuna Miura, Toshikatu Taniki and Nobuyuki Tanida : Rapidly growing mature teratoma of the mediastinum: do sex hormones affect growth of the tumor?, Journal of Surgical Oncology, Vol.38, No.4, 285-289, 1988. (Keyword) mediastinal teratoma / rapid growth / estrogen receptor / progesterone receptor
105.	Kozo Inui, Tadaoki Morimoto, Kansei Komaki, Hiroshi Sonoo and Yasumasa Monden : Changes in the hormone dependency of DMBA-induced rat mammary tumors with reference to the effect of tamoxifen, The Japanese Journal of Surgery, Vol.18, No.3, 284-290, 1988. (Summary) Tamoxifen was administered over a period of 4 weeks to 19 female Sprague-Dawley rats bearing 20 DMBA-induced mammary tumors. Consequently, 13 tumors (65.0 per cent) regressed and showed a reduction in their estradiol receptor (ER) and progesterone receptor (PgR) concentrations. In spite of subsequent treatment given to the rats bearing the regressed tumors, 6 new tumors occurred. The ER and PgR concentrations of these tumors were lower than those of the tumors before tamoxifen therapy, and histochemical study showed these tumors to be composed mostly of ER-negative cells. These results suggest that: (a) the hormone dependency of breast cancer is reduced by tamoxifen therapy; (b) breast cancers recurring during tamoxifen therapy show reduced hormone dependency. (Keyword) DMBA-induced rat mammary tumors / fluorescent estradiol conjugate / hormone receptor / tamoxifen (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 3136267 ● Search Scopus @ Elsevier (PMID): 3136267 (PubMed: 3136267)
106.	Kansei Komaki, Goi Sakanoto, Haruo Sugano, Tadaoki Morimoto and Yasumasa Monden : Mucinous carcinoma of the breast in Japan. A prognostic analysis based on morphologic features, Cancer, Vol.61, No.5, 989-996, 1988.
107.	Tadaoki Morimoto, Kansei Komaki, Kazushi Oshiro, Takashi Yamakawa, Nanretsu Mitsnyana, Takashi Tanaka and Yasumasa Monden : Breast cancer detected by mass screening using physical examination alone, The Japanese Journal of Surgery, Vol.17, No.5, 377-381, 1987. (Keyword) breast cancer / mass screening / physical examination / interval cancer / breast self-examination
108.	Tadaoki Morimoto, Kansei Komaki, Kozo Inui, Atsushi Unemoto, Hiroyuki Yamamoto, Kunihiko Harada and Kenji Inoue : Involvement of nipple and areola in early breast cancer, Cancer, Vol.55, No.10, 2459-2463, 1985.
109.	Tadaoki Morimoto, Kansei Komaki, Kozo Inui, Kenichi Nishimoto, Hiroshi Sonoo, Kunihiko Harada and Kenji Inoue : Minor surgery for early cancer of the breast--from the clinicopathological study--, The Tokushima Journal of Experimental Medicine, Vol.30, No.1-2, 1-7, 1983. (Keyword) breast cancer / Early stage / Multi sliced specimen / Cancerous extension / Minor surgery
110.	Kenji Inoue, Tadaoki Morimoto, Hiroshi Sonoo, Yasushi Koshiba, Muneo Kitamura, Etsuo Kakuta and Haruo Fujiwara : An evaluation of mass screening for breast cancer, The Japanese journal of surgery, Vol.11, No.1, 22-26, 1981. (Keyword) breast cancer / physical examination / interval cancer / detection rate
111.	Takao Hattori, Minoru Niimoto, Akira Nakano, Eiji Itagaki, Kenji Inoue and Tadaoki Morimoto : Biopsy of the breast, The Japanese journal of surgery, Vol.10, No.4, 270-276, 1980. (Keyword) questionnaire / surgical biopsy / breast cancer / excisional / incisional
112.	Kunio Ii, Kazuo Hizawa, Kuniyasu Okazaki, Tadaoki Morimoto and Yukihisa Uyama : Liposarcoma of the breast--fine structural and histochemical study of a case and review of 42 cases in the literature, The Tokushima Journal of Experimental Medicine, Vol.27, No.3-4, 45-56, 1980.
113.	Kenji Inoue, Kuniyasu Okazaki, Tadaoki Morimoto, Masami Hayashi, Yukihisa Uyama, Hiroshi Sonoo, Yasushi Koshiba, Tetsuichi Takihara, Yasuo Nomura, Jun Yamagata, Hideaki Kondo, Kazuhiro Kanda and Kenji Takenaka : Therapeutic value of mepitiostane in the treatment of advanced breast cancer, Cancer treatment reports, Vol.62, No.5, 743-745, 1978.

Academic Paper (Unrefereed Paper):

1.	Toshiko Tada, Tadaoki Morimoto, 山本澄子 and Yumi Kuwamura : 生活習慣と肥満尺度の関連性の検討, Quality Nursing, Vol.4, No.1, 37-42, 1998.
2.	山本澄子, Tadaoki Morimoto, Toshiko Tada, Yumi Kuwamura and Takako Ichihara : 生体インピーダンス法(BIA法)，近赤外分光法および皮脂厚計による肥満測定, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.6, 137-143, 1996.

Academic Letter:

1.	Yasuhiro Kaneda, Tadaoki Morimoto and Akira Fujii : Gynecomastia induced by treatment with tandospirone, a 5-HT1A agonist, Journal of Psychiatry & Neuroscience, Vol.26, No.2, 152-153, 2001. (Keyword) Adult / Gynecomastia / Humans / Isoindoles / Male / Piperazines / Pyrimidines / Serotonin Receptor Agonists (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11291533 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035037281 (PubMed: 11291533, Elsevier: Scopus)

Review, Commentary:

1.	Tadaoki Morimoto : 画像診断器機・システムの展望「最新マンモグラフィがもたらす有用性」, 新医療, Vol.33, Apr. 2006.
2.	岡崎正敏, 遠藤登喜子, 東野英利子, 大貫幸二, 福田護, 木村千明, 堀田勝平, 今村恵子, 土橋一慶, 梶谷典子, 寺田央, 王丸明子 and Tadaoki Morimoto : マンモグラフィ検診精度管理中央委員会の現状と課題, Journal of Japan Association of Breast Cancer Screening, Vol.15, No.1, 19-26, 2006.
3.	遠藤登喜子, 岩瀬拓士, 宇津野栄, 大貫幸二, 大村峯, 木村千明, 古妻嘉一, 角田博子, 寺田央, 東野英利子, 堀田勝平, 梶谷典子 and Tadaoki Morimoto : マンモグラフィ検診精度管理中央委員会の現状と課題, Journal of Japan Association of Breast Cancer Screening, Vol.15, No.1, 12-18, 2006.
4.	Tadaoki Morimoto, 福田護, 岡崎正敏, 遠藤登喜子, 大内憲明, 光山昌珠, 佐野宗明, 東野英利子, 永井宏, 土橋一慶, 堀田勝平, 逸見典子, 今村恵子, 木村千明, 横江隆夫, 岩瀬拓士, 寺田央, 富永祐民, 飯沼武 and 坂元吾偉 : マンモグラフィ検診精度管理中央委員会の現状と課題, Journal of Japan Association of Breast Cancer Screening, Vol.15, No.1, 4-11, 2006.
5.	Tadaoki Morimoto and Mari Haku : Effectiveness of Mammographic Screening and Tasks of Screening for Breast Cancer in Japan, Japanese Journal of Radiological Technology, Vol.61, No.6, 749-758, Jun. 2005. (Keyword) General Medicine (Link to Publication Site) ● Publication site (DOI): 10.6009/jjrt.kj00003326832 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282681365636480 ● Summary page in Scopus @ Elsevier: 2-s2.0-23844548376 (DOI: 10.6009/jjrt.kj00003326832, CiNii: 1390282681365636480, Elsevier: Scopus)
6.	Tadaoki Morimoto : 乳房内石灰化像の診断, Japan Medical Journal, No.4192, 90-91, Aug. 2004.
7.	寺田央, 堀田勝平, 岡崎正敏, 遠藤登喜子, 今村惠子, 大貫幸二, 東野英利子, 逸見典子, 木村千明, 王丸明子, 土橋一慶, 福田護 and Tadaoki Morimoto : 施設画像評価委員会の現状, Journal of Japan Association of Breast Cancer Screening, Vol.13, No.2, 205-209, Jun. 2004. (Keyword) マンモグラフィ / 画像評価 / 品質管理
8.	Tadaoki Morimoto, Kansei Komaki, Junji Ueno and Minoru Irahara : 都道府県の乳がん部会と精中委とのあり方, 日本乳癌検診学会誌, Vol.13, No.2, 195-204, Jun. 2004.
9.	今村恵子, 寺田央, 岡崎正敏, 堀田勝平, 遠藤登喜子, 東野恵利子, 大貫幸二, 逸見典子, 石栗一男, 福田護, Tadaoki Morimoto and 大内憲明 : マンモグラフィ実施機関についての施設認定, 新医療, No.4, 2-5, Apr. 2004.
10.	Tadaoki Morimoto, Masatoshi Okazaki and Tokiko Endo : Current Status and Goals of Mammographic Screening for Breast Cancer in Japan, Breast Cancer, Vol.11, No.1, 73-81, Jan. 2004. (Summary) In Europe and the United States, the proportion of women receiving mammographic screening for breast cancer has increased to 60-80%, resulting in an increase in the detection of early-stage cancer and a reduction in the mortality rate. The objectives of breast cancer screening have thus already been achieved there. In Japan, both the incidence and mortality of breast cancer have increased recently. Breast cancer screening has long been performed by clinical breast examination (CBE) alone. A reduction in the mortality of breast cancer cannot be expected from CBE. Mammographic screening for breast cancer was recommended in a notification issued by Ministry of Health, Labour and Welfare in 1999. An important aspect of mammographic screening is quality control. The Central Committee on Quality Control of Mammographic Screening(Central Committee)was organized by six screening-related societies, and attempts have since been made to establish a quality control system. Both the social recognition of the Central Committee and its cooperation with the "Quality Control Committee " of each community will become important. The cover rate of nationwide breast cancer screening by CBE alone is 12-13%, while the implementation rate of mammographic screening is presently very low and its cover rate is considered to be about 2%. With such a low cover rate, it is absolutely impossible to reduce the mortality of breast cancer. To achieve this, the administration and clinicians will be required to cooperate with each other to increase the spread and cover rate of high-quality mammographic screening. (Keyword) breast cancer / Mortality reduction / Mammographic screening / Quality control system / Central committee (Link to Publication Site) ● Publication site (DOI): 10.1007/BF02968007 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14718797 ● Search Scopus @ Elsevier (PMID): 14718797 ● Search Scopus @ Elsevier (DOI): 10.1007/BF02968007 (DOI: 10.1007/BF02968007, PubMed: 14718797)
11.	Tadaoki Morimoto : 健診で異常を指摘された人へのベストガイドがん検診での異常-乳癌, JIM, Vol.13, No.4, 339-342, Apr. 2003.
12.	Tadaoki Morimoto and 田中隆 : 産婦人科医のための目で見るマンモグラフィ入門(6回) 症例提示によるマンモグラフィ読影の実際その他の所見乳腺実質の所見·皮膚所見·リンパ節所見, Obstetrical and Gynecological Therapy, Vol.85, No.6, 701-709, Dec. 2002. (Keyword) マンモグラフィ / 読影 / カテゴリー分類 / その他の所見
13.	Tadaoki Morimoto and 田中隆 : 産婦人科医のための目で見るマンモグラフィ入門(5回) 症例提示によるマンモグラフィ読影の実際(石灰化), Obstetrical and Gynecological Therapy, Vol.85, No.5, 577-584, Nov. 2002. (Keyword) マンモグラフィ / 読影 / カテゴリー分類 / 石灰化
14.	岡崎邦泰 and Tadaoki Morimoto : 癌診療に役立つ最新データⅣ．乳癌乳癌の疫学に関する最新のデータ, 臨床外科, Vol.57, No.11, 74-79, Oct. 2002.
15.	Tadaoki Morimoto and 田中隆 : 産婦人科医のための目で見るマンモグラフィ入門(4回) 症例提示によるマンモグラフィ読影の実際(腫瘍), Obstetrical and Gynecological Therapy, Vol.85, No.4, 453-461, Oct. 2002. (Keyword) マンモグラフィ / 読影 / カテゴリー分類 / 腫瘤
16.	Tadaoki Morimoto and 田中隆 : 産婦人科医のための目で見るマンモグラフィ入門(3回) 症例提示による読影のポイント, Obstetrical and Gynecological Therapy, Vol.85, No.3, 348-357, Sep. 2002. (Keyword) 読影の基本 / 所見用語 / カテゴリー分類 / 総論
17.	Tadaoki Morimoto and 田中隆 : 産婦人科医のための目で見るマンモグラフィ入門(2回) マンモグラフィ診断技術の進歩, Obstetrical and Gynecological Therapy, Vol.85, No.2, 234-239, Aug. 2002. (Keyword) マンモグラフィ診断 / 乳房用X線装置 / 受光系 / 現象 / 精度管理
18.	Tadaoki Morimoto and 田中隆 : 産婦人科医のための目で見るマンモグラフィ入門(1回) 乳癌検診におけるマンモグラフィによる診断の今日的意義, Obstetrical and Gynecological Therapy, Vol.85, No.1, 95-101, Jul. 2002. (Keyword) マンモグラフィ診断 / 乳癌検診 / 早期発見 / 死亡率減少
19.	Tadaoki Morimoto, 笹三徳, 相良安信 and 山口哲央 : 徳島県におけるマンモグラフィ検診の経緯と実情, Journal of Japan Association of Breast Cancer Screening, Vol.11, No.2, 219-221, Jun. 2002.
20.	浅石和昭, 弥生恵司, 森谷卓也, 市原周, 井内康輝, Tadaoki Morimoto and 大内憲明 : Atypical Ductal Hyperplasia;ADH, Journal of Japan Association of Breast Cancer Screening, Vol.11, No.2, 193-198, Jun. 2002.
21.	Tadaoki Morimoto : マンモグラフィ検診による乳癌死亡率減少効果と本邦の乳癌検診の課題, Shikoku Acta Medica, Vol.58, No.1-2, 1-10, Apr. 2002. (Tokushima University Institutional Repository) ● Metadata: 110520 (Tokushima University Institutional Repository: 110520)
22.	Tadaoki Morimoto : 質疑応答，乳癌術後の予防接種および感染症予防, Japan Medical Journal, No.4048, 105-106, Nov. 2001.
23.	Tadaoki Morimoto : 【乳癌検診の実際】フォローアップ症例に対する説明と取り扱い, 臨床婦人科産科増刊号「婦人科医のための乳癌検診」, Vol.55, No.4, 508-513, Apr. 2001.
24.	Tadaoki Morimoto, 遠藤登喜子, 岡崎正敏, 福田護, 大内憲明, 小田切邦雄, 永井宏, 土橋一慶, 堀田勝平, 石栗一男, 前越久, 今村惠子, 岩瀬拓士, 横江隆夫, 富永祐民, 飯沼武 and 坂本吾偉 : マンモグラフィ検診精度管理中央委員会の役割について, Journal of Japan Association of Breast Cancer Screening, Vol.10, No.1, 71-87, Mar. 2001. (Keyword) マンモグラフィ / 乳癌検診 / 精度管理中央委員会
25.	Tadaoki Morimoto, 遠藤登喜子 and 岡崎正敏 : 乳癌検診におけるマンモグラフィ検診精度管理中央委員会の役割, Japan Medical Journal, No.4005, 37-42, Jan. 2001.
26.	Tadaoki Morimoto, Yumi Kuwamura, 島田洋子, Fumiko Hashimoto and Toshiko Tada : 乳癌検診の今, Ope Nursing, No.1999, 240-247, Sep. 1999.
27.	Tadaoki Morimoto and Mitsunori Sasa : Current Status of Screening for Breast Cancer and Tasks for Introduction of Mammographic Screening in Japan, Breast Cancer, Vol.5, No.3, 227-234, 1998.

Proceeding of International Conference:

1.	Emiko Yasuno, Xueli Zhao, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Okazaki Kenji, Ikeda Yuichi, Sato Yasuhiro and Ichida Teruhiro : A fundamental study on theory of space distribution estimation for EIT, Proceedings of the International Symposium on Biological and Physiological Engineering /The 22nd SICE Symposium on Biological and Physiological Engineering, 353-354, Harbin, Jan. 2008. (Keyword) bio-impedance / tissue equivalent circuit model / Gauss-Newton metohd
2.	Teruhiro Ichida, Yuichi Ikeda, Emiko Yasuno, Kenji Okazaki, Yasuhiro Sato, Akira Tangoku, Yohsuke Kinouchi and Tadaoki Morimoto : Improvement of bio-impedance measurement accuracy with guard electrodes approach, International journal of bioelectromagnetism, Vol.9, No.1, 126-127, Aizuwakamatsu, Oct. 2007.
3.	Ikeda Yuichi, Sato Yasuhiro, Yohsuke Kinouchi, Emiko Yasuno, Omine Yuken, Akira Tangoku and Tadaoki Morimoto : Nomivasive Estimation of Tissue Impedance Based on an Equivalent Circuit Model, Proceedings of the Intenational Conference on Biomedical and Pharmaceutical Engineering, 246-251, Singapore, Dec. 2006.
4.	Arisa Morimoto, Emiko Yasuno, Yohsuke Kinouchi, Y Omine, Akira Tangoku and Tadaoki Morimoto : Spatial Resolution in the Electrical Impedance Tomography for the Local Tissue, Proceedings of the 27th Annual Conference of the IEEE-EMBS, Vol.7, 6638-6641, Shanghai, Sep. 2005. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-33846900947 (Elsevier: Scopus)
5.	Emiko Yasuno, Kato Hiromi, Yohsuke Kinouchi and Tadaoki Morimoto : A Fundamental Study on Parameter Estimation of Layerd Local Tissue Impedance for EIT, Proceedings of the 27th Annual Conference of the IEEE-EMBS, Vol.7, 6650-6653, Shanghai, Sep. 2005. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-33846924838 (Elsevier: Scopus)
6.	Morimoto Arisa, Kato Hiromi, Emiko Yasuno, Yohsuke Kinouchi and Tadaoki Morimoto : Theoretical study on local tissue EIT and its spatial resolution, 6th Asian-Pacific Conference on Medical and Biological Engineering(APCMBE2005), Tsukuba, Apr. 2005.
7.	Hiromi Kato, Emiko Yasuno, Yohsuke Kinouchi and Tadaoki Morimoto : Electrical Impedance Tomography for Local Biological Tissue, Proceedings of 8th International Conference on Control, Automation, Robotics and Vision, 942-946, Kunming, Dec. 2004. (Summary) Electrical impedance tomography (EIT) is 2-D or 3-D image of electrical impedance distribution in a living tissue. It has become expected as a different method to obtain a tissue characteristic for various medical diagnoses. To realize a practical EIT measurement system, it is an important subject to choose a proper configuration of the electrodes, because the EIT is estimated from impedance data, which is measured non-invasively by surface electrodes. In this study, a new configuration of the electrodes, called divided electrode, is proposed for a short time measurement of bio-impedance in a cross section of a local tissue. Its capability is examined by computer simulations, where a distributed equivalent circuit is used as a model in the cross section of the tissue. Estimation of impedance parameters is carried out by use of the Newton Method. Usefulness of the proposed method is confirmed by computer simulations using a typical layered tissue model.
8.	Emiko Yasuno, Xueli Zhao, Yohsuke Kinouchi, Tadaoki Morimoto, Mieko Takeuchi and Yuuken Oomine : Parameter Estimation of the Local Tissue Impedance by Using Divided Electrode for EIT, 2004 RISP International Workshop on Nonlinear Circuits and Signal Processing, 379-382, Honolulu, Mar. 2004.
9.	Hiroyuki Bando, Emiko Yasuno, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : A New Method for Estimating Bioimpedance Distribution in a Local Tissue Using Divided Electrodes - Towards Local EIT, Proceedings of World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia, August 24-29, 2003, MO.TR1-38, Sydney, Aug. 2003.
10.	Kenji Izukura, Xueli Zhao, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : A New Method of Electrical Impedance Tomography for Conductivity Distribution in Multi-layer Local Tissue from Non-invasively Measured Bioresistances, international Congress on Biological and Medical Engineering Programme&Handbook, 132, Singapore, Dec. 2002.
11.	Yumi Komai, Emiko Yasuno, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : Theoretical Studies on Electrical Impedance Tomography Based on Equivalent Circuits for the Local Tissue by Use of a Divided Ilectrode, international Congress on Biological and Medical Engineering Programme&Handbook, 50, Singapore, Dec. 2002.
12.	Xueli Zhao, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : Estimation of Conductivity Distribution in the Local Tissue Using a Divided Electrode, Proceedings of The International Technical Conference on Circuits/Systems, Computers and Communications, Vol.2, 1262-1267, Tokushima, Jul. 2001.
13.	Yasuhiro Kaneda, Tadaoki Morimoto and Akira Fujii : Effects of tandospirone on the hypothalamo-pituitary-gonadal axis of male patients, Scientific Meeting of the Pacific Rim College of Psychiatrists, Seoul, Oct. 1999.
14.	Risuke Kojima, Xueli Zhao, Yohsuke Kinouchi, Tadamitsu Iritani and Tadaoki Morimoto : Parameter Estimation of Distributed Equivalent Circuits for the Tissue, Proceedings of The 4th Asia-Pacific Conference on Medical and Biological Engineering, 451, Seoul, Sep. 1999.
15.	Norihide Momose, Yohsuke Kinouchi, Tadamitsu Iritani, Y Konishi, Tadaoki Morimoto and I Kato : Three dimensional analysis of local tissue impedance by finite element method, Medical & Biological Engineering & Computing, Vol.35, No.Suppl. Part 1, 347, Nice, France, Sep. 1997.
16.	Yohsuke Kinouchi, Emiko Fujimoto and Tadaoki Morimoto : Equivalent distributed circuits for bioimpedance of nonuniform tissue, Medical and Biological Engineering and Computing, Vol.35, No.Suppl. Part 1, 347, Nice, France, Sep. 1997.

Proceeding of Domestic Conference:

1.	Junko Honda, 笹三徳, 高橋雅子, 廣瀬千恵子, 生島葉子, 井上光郎, 三木仁司, 鎌田正晴, 濱田信一, Yoshimi Bando, Akira Tangoku and Tadaoki Morimoto : マンモグラフィ所見の変化からみた乳癌の悪性度, 第26回日本乳癌検診学会学術総会, Nov. 2016.
2.	橋本公子, Mari Haku and Tadaoki Morimoto : 開業助産師による母乳育児支援 -乳腺外科医との連携を通して-, 徳島母性衛生学会抄録集, Sep. 2014. (Keyword) 母乳育児支援 / 開業助産師 / 乳腺外科 / 乳腺炎
3.	Tomoya Takahashi, Masatake Akutagawa, Takahiro Emoto, Shinsuke Konaka, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki and Emiko Yasuno : Study of a measurement device for bioelectrical impedance using multi-electrode and lock-in amplifier, 2013 Shikoku-section Joint Convention Record of the Institutes of Electrical and Related Engineers, 239, Sep. 2013. (Summary) 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．一方，生体インピーダンスを皮膚表面から測定する場合には，測定信号のSNRが小さいことが多く，測定が困難である．そこで耐雑音性に優れるロックインアンプを製作し，測定の安定化を図った．
4.	Iwami Seiji, Masatake Akutagawa, Takahiro Emoto, Shinsuke Konaka, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki, Emiko Yasuno and Tomoya Takahashi : Study for the electrode arrangement of the impedance measureing device in consideration of the variation of the biological tissue impedance, 2013 Shikoku-section Joint Convention Record of the Institutes of Electrical and Related Engineers, 238, Sep. 2013. (Summary) 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．一方，生体インピーダンスを皮膚表面から測定する場合，電流が拡散するため局所的な腫瘍組織のインピーダンスを測定することが困難である．そこで複数の電極対を切り替えることにより標的とする領域のインピーダンスを測定することを試みている．
5.	Takuto Inoko, Masatake Akutagawa, Takahiro Emoto, Shinsuke Konaka, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki, Emiko Yasuno, Tomoya Takahashi and Seiji Iwami : 生体インピーダンスを用いた腫瘍の質的診断のための電極配置の検討, 第35回日本生体医工学会中国四国支部大会講演抄録, 17, Oct. 2012. (Summary) 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．一方，生体インピーダンスを皮膚表面から測定する場合，電流が拡散するため局所的な腫瘍組織のインピーダンスを測定することが困難である．そこで複数の電極対を切り替えることにより標的とする領域のインピーダンスを測定することを試み，計算機シミュレーションにより電極の切り替え法について検討した．
6.	Takuto Inoko, Masatake Akutagawa, Takahiro Emoto, Shinsuke Konaka, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki, Emiko Yasuno, Tomoya Takahashi and Seiji Iwami : Examination of qualitative diagnosis of tumors by measurement of the bioelectrical impedance, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 261, Sep. 2012. (Summary) 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．皮膚表面の電極ついに一定電圧を印加し，腫瘍部分のインピーダンスの推定が可能かについて有限要素法により検討した．その結果，皮膚表面に現れる電圧分布の差異は非常に小さく，インピーダンス推定が非常に困難であることが示された．
7.	Tomoya Takahashi, Masatake Akutagawa, Takahiro Emoto, Shinsuke Konaka, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki and Emiko Yasuno : Development of a bioelectrical impedance device with multiple electrodes, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 260, Sep. 2012. (Summary) 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．多電極の生体インピーダンス測定装置を試作し，大腿部のインピーダンスの測定を行い，有用性を検証した．
8.	Seiji Iwami, Masatake Akutagawa, Takahiro Emoto, Shinsuke Konaka, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki, Emiko Yasuno, Takuto Inoko and Tomoya Takahashi : Study of multi-electrode impedance measureng device of using a biological tissue equivalent circuit simulation, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 259, Sep. 2012. (Summary) 生体の電気インピーダンスは組織の状態により異なる値を示すことが知られている．乳がんの診断支援に応用した場合，非侵襲で対象組織の悪性，良性の区別をすることができる可能性がある．3パラメータの2次元生体組織回路網モデルを構築し，組織内の電流分布を解析した．電流電極を切り替える事で，電流の流れる層が変化する事や，電圧変化があることを示した．
9.	Takuto Inoko, Masatake Akutagawa, Takahiro Emoto, Shinsuke Konaka, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki, Mikio Miyakogawa and Emiko Yasuno : Biological impedance parameter presumption with lattice circuit, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 237, Sep. 2011. (Summary) 生体組織インピーダンス測定値に最小誤差で適合する二次元等価回路のパラメータ決定を行うために，皮下組織の層状構成を考慮し，かつ周波数依存性のないパラメータを要素とする回路構成を検討した．また生体組織を実測し，抵抗値および導電率の推定を行った．
10.	Masakazu Goto, 三浦連人, 木下貴史, 松山和男, Tadaoki Morimoto, Masanori Nishioka, Mitsuo Shimada and Seiki Tashiro : 下部直腸癌に対する術前化学放射線療法の効果 (第66回日本消化器外科学会総会), 日本消化器外科学会総会, 841, Jul. 2011. (Keyword) 直腸腫瘍 / 治療成績 / ネオアジュバント療法 / 放射線化学療法 / Homo sapiens
11.	Keigo Hattori, Takuto Inoko, Shinsuke Konaka, Yohsuke Kinouchi, Masatake Akutagawa, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki, Mikio Miyakogawa and Emiko Yasuno : Research on living body impedance parameter presumption, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 197, Sep. 2010.
12.	Keigo Hattori, Ryousuke Kotani, Yohsuke Kinouchi, Masatake Akutagawa, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki and Emiko Yasuno : Research on living body impedance parameter presumption, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 240, Sep. 2009.
13.	Ryousuke Kotani, Keigo Hattori, Yohsuke Kinouchi, Masatake Akutagawa, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki and Emiko Yasuno : Verification of the guard electrode effect with bioimpedance measurement, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 239, Sep. 2009.
14.	小谷亮介, 櫟田英広, Yohsuke Kinouchi, Masatake Akutagawa, Tadaoki Morimoto, Akira Tangoku, 岡崎憲二 and Emiko Yasuno : Verification of the guard electrode effect using a salt solution phantom, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 239, Sep. 2008.
15.	櫟田英広, 小谷亮介, Yohsuke Kinouchi, Masatake Akutagawa, 岡崎憲二, Akira Tangoku, Tadaoki Morimoto and Emiko Yasuno : Verification of Bio-Impedance Measurement Device, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 240, Sep. 2008.
16.	Ikeda Yuichi, Sato Yasuhiro, Ichida Teruhiro, Emiko Yasuno, Yohsuke Kinouchi, Okazaki Kenji, Akira Tangoku and Tadaoki Morimoto : Development of Noninvasive Bio-impedance Measuring Method for Breast Cancer Diagnosis, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 398, Sep. 2007.
17.	櫟田英広, 池田祐一, 佐藤康弘, Yohsuke Kinouchi, 岡崎憲二, Akira Tangoku, Tadaoki Morimoto and Emiko Yasuno : Verification of Bio-Impedance Measurement Device with Saltwater Phantom, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 221, Sep. 2007.
18.	佐藤康弘, 池田祐一, 櫟田英広, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, 岡崎憲二 and Emiko Yasuno : Analysis of electrical current distribution in tissue inn Bio-impedance measurement, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 220, Sep. 2007.
19.	Morimoto Arisa, Emiko Yasuno, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku and Omine Y. : Theoretical study of spatial resolution in the local tissu EIT, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 223, Sep. 2005.
20.	Takako Ichihara, Ayako Tamura, 片岡健, 宮腰由紀子, Tadaoki Morimoto, Takako Minagawa and Yumi Kuwamura : 下肢伸筋·屈筋の筋組織厚と術後臥床日数の関係, 第3回日本リハビリテーション看護学会学術大会集録, 96-98, Oct. 2004.
21.	Morimoto Arisa, Emiko Yasuno, Yohsuke Kinouchi and Tadaoki Morimoto : 局所組織EITの空間分解能の検討, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, Sep. 2004.
22.	Kato Hiromi, Emiko Yasuno, Yohsuke Kinouchi and Tadaoki Morimoto : 生体組織インピーダンスの層組織構造の推定, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, Sep. 2004.
23.	Hajime Miura, Kouichi Murakami, Tadaoki Morimoto, 田上周路 and Yoshio Hayasaki : 近赤外分光装置による乳房部の代謝測定, 第10回医用近赤外線分光法研究会, Nov. 2003. (Summary) 近赤外分光(NIRS)装置は非侵襲的方法のために，骨格筋，脳，肝臓などの様々な生体組織の代謝が測定可能である．近年，このNIRSの特徴を利用して，乳がんを診断する装置の開発が行われている．本研究では，近年の乳がんの罹患率の増加を踏まえ，自己検診を目指した小型NIRS装置を開発し，in vivoでの測定により評価検討した．測定プローブは7×10cmの扇型であり，光源を中心に2組の受光部(距離:1.5cm，3.0cm)が45度の角度で構成されている．第1実験として，本装置を用いて，6名の成人女性に排卵前後の乳房の上部外側の酸素動態の変化を測定した．その結果，排卵前に比べて排卵後では血液量の有意な増加が認められ，NIRSを用いて乳腺の変化を可視化することが可能であることが示された．第2実験として，乳がん患者を対象に乳頭部を中心に扇型のプローブを45度ずつ円形に移動させながら，乳房部全体の代謝を測定した．その結果，がん組織が存在する部分では他の部分と異なり，脱酸素化Hbおよび血液量の顕著な増加が認められ，本測定装置での乳がん検出の可能性が示唆された．一方，測定方法，特にプローブと乳房部の接触により生じる圧の影響で，データに大きな誤差が生じることが明らかになったため，今後，再現性の高い測定方法を見出す必要性が示された．
24.	Takako Ichihara, Ayako Tamura, 西亀正之, 宮腰由紀子, Takako Minagawa, Yumi Kuwamura, Tadaoki Morimoto and 片岡健 : ベッド上安静に伴う下肢の筋組織厚の変化, 第2回日本リハビリテーション看護学会学術大会集録, Vol.5-17, 49-51, Oct. 2003.
25.	芝篤志, Hiroaki Yasuda, 中川崇, Hiromu Nishitani, Hitoshi Ikushima, Yoshihiro Takegawa, Tadaoki Morimoto and 笹三徳 : 乳房温存療法の長期予後, 第98回日本医学放射線学会中国·四国地方会(岡山) 2002.6. 日本医学放射線学会雑誌, Vol.62, No.14, 54, Dec. 2002.
26.	児島理介, 安野恵美子, Yohsuke Kinouchi and Tadaoki Morimoto : 生体組織インピーダンスの空間分布推定, 第22回日本エム・イー学会中国四国支部大会抄録集, 34, Nov. 1999.
27.	笹三徳, Tadaoki Morimoto, 柏原賢一, Yoshihiro Takegawa, Keisuke Izumi and Nobuya Sano : 乳房温存療法における乳房照射の有効性について, 第4回日本乳癌学会総会(東京), Jun. 1996.
28.	笹三徳, Tadaoki Morimoto, 柏原賢一, Yoshihiro Takegawa and Yasumasa Monden : 乳房温存療法の短期成績, 第3回日本乳癌学会総会(大阪), Jun. 1995.

Et cetera, Workshop:

1.	Seiji Iwami, Masatake Akutagawa, Takahiro Emoto, Shinsuke Konaka, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki, Emiko Yasuno, Takuto Inoko and Tomoya Takahashi : Investigation of electrode arrangement for the bioimpedance measurement of tumor tissue, IEICE Technical Report, Vol.112, No.123, 25-29, Jul. 2012. (Summary) Electrical resistance of normal tissue is different to electrical resistance of malignant tissue that is known by past study. A fixed measuring electrode device has so far been developed. In this study, we investigated the effect of measurement of different in electrode placement using the biological equivalent circuit model. As results of simulation using the biological equivalent circuit, the pr esented electrode arrangement seems to be effective in bio impedance measurement of tumor tissue. (Keyword) simulation / electrode arrangement / biological equivalent circuit model
2.	岩見誠治, Masatake Akutagawa, Takahiro Emoto, Shinsuke Konaka, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Kenji Okazaki, 安野恵美子, 猪子拓人 and 高橋知也 : 浅部腫瘍生体組織インピーダンス測定のための電極配置について, IEICE Technical Report (MBE), Vol.112, No.123, 25-29, 2012. (Keyword) 異物(診断)
3.	Yoshie Imai, Chiemi Onishi, Chiemi Kawanishi, Tadaoki Morimoto, Tatuko Hujimura, Masami Satou and Natuko Takahashi : 乳がん患者に対する看護職による情報提供の実態, 徳島乳腺研究会, Apr. 2007.
4.	笹三徳, Tadaoki Morimoto, 山本弘幸, 乾浩三, 田中克浩, 杉本友則, 柏原賢一, Yoshihiro Takegawa and Yasumasa Monden : 乳房温存療法の短期成績, 第17回徳島乳腺疾患懇話会, Jan. 1995.
5.	Yoshihiro Takegawa, Tadaoki Morimoto, Junji Ueno and 柏原賢一 : 徳島大学放射線科における乳房温存療法の現状, 第15回徳島乳腺疾患懇話会, Jan. 1994.

Report:

1.	Mari Haku, Tadaoki Morimoto and Mieko Takeuchi : 産褥期の乳汁分泌に関与する乳腺構造分析と母乳哺育継続要因に関する研究, 平成15∼16年度科学研究費補助金(基盤研究(c)(2))研究成果報告書, 1-58, Mar. 2005.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Development of a breast-feeding prediction scale and inspection of the utility (Project/Area Number: 17592249 )
新しい分割電極によるインピーダンスCT開発に関する研究 (Project/Area Number: 16650111 )
Development of a self-care support program centering on providing information for breast cancer (Project/Area Number: 16390639 )
Analysis of the mammary gland structure involved in lactation and factors associated with breast-feeding continuation (Project/Area Number: 15592269 )
The research on mammary gland growth evaluation with the progress and impovement on the care technology of the pregnancy (Project/Area Number: 12672324 )
Researches on Biological Functions for New Technologies (Project/Area Number: 09045054 )
ハイパーサーミア用アプリケータの開発に関する研究 (Project/Area Number: 04670735 )
生体の電気インピ-ダンスに関する研究 (Project/Area Number: 03670589 )
A study of measurements of electrical bio-impedance in breast tumors (Project/Area Number: 60570592 )
Search by Researcher Number (10112244)

Professor Emeritus : Morimoto, Tadaoki

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)