Tadaoki Morimoto, Akira Tangoku, Takashi Yamakawa, Masaki Tsuruno and Shigemitsu Takashima : Promotion of quality-controlled mammography alone as a screening modality in Japan., Breast Cancer, 21, 4, 435-441, 2012.
(要約)
BACKGROUND: The rate of breast cancer screening in Japan has not increased, and it is thought that one of the reasons is the principle that mammography (MMG) and clinical breast examination (CBE) be carried out in combination. Nationwide, there is a shortage of physicians qualified to perform CBE, and in some regions mass-screening is performed by MMG alone out of a mobile MMG bus. In Shikoku, MMG is performed alone as a screening examination in Kochi and Ehime Prefectures. METHODS: A comparative analysis of the data generated by MMG alone in breast cancer screening in the four prefectures of Shikoku during the 2005-2009 period was performed. RESULTS: The overall attendance rates, recall, cancer detection, early-stage cancer detection, and the positive predictive value (PPV) were 16.8-24.5, 6.0-12.8, 0.26-0.37, 63.1-79.7, and 2.8-4.3 %, respectively. Almost no differences were seen between the results for MMG alone and combined MMG/CBE screening. In addition, the cancer detection rates based on the Japan Cancer Society's nationwide data were 0.25 % with combined MMG/CBE screening and 0.21 % with MMG alone, showing almost no difference. CONCLUSIONS: No differences were seen between the results (i.e., recall rate, cancer detection rate, early-stage cancer detection rate, PPV) for MMG alone and MMG/CBE screening in the four prefectures of Shikoku compared with the Japan Cancer Society's nationwide data. In order to improve the mammographic screening rate in Japan, quality-controlled mammography as a stand-alone examination should be promoted, and performed biennially for women aged 50-74 years.
Kenji Okazaki, Akira Tangoku, Tadaoki Morimoto, Ryosuke Kotani, Keigo Hattori, Emiko Yasuno, Masatake Akutagawa and Yohsuke Kinouchi : Basic study of a diagnostic modality employing a new electrical impedance tomography (EIT) method for noninvasive measurement in localized tissue, The Journal of Medical Investigation : JMI, 57, 3,4, 205-218, 2010.
(要約)
The objective of this study is to develop a device for noninvasive local tissue electrical impedance tomography (EIT) using divided electrodes with guard electrodes and to validate its effectiveness using bioequivalent phantoms. For this purpose, we prepared a measurement device and bioequivalent phantoms, measured the electrical characteristics of the phantoms, and validated the method using the phantoms. Monolayer phantoms mimicking the brain and muscle and bilayer phantoms consisting of muscle and brain layers were prepared. The relative differences between the measured electrical conductivities of the monolayer brain and muscle phantoms and the true values determined by the 4-electrode method were both less than 10%. The relative differences between the measured and true values in the bilayer phantoms were less than 20% in both layers. The biological impedance measurement device that we developed was confirmed to be effective for impedance measurement in bilayer phantoms with different electrical impedances. To develop a device for the early diagnosis of breast diseases, the development of a multi-layer phantom and demonstration of the effectiveness of the device for its examination are necessary. If the device that we developed makes impedance measurement in breast tumors possible, it may be used as a new diagnostic modality for breast diseases.
Taeko Nagao, Yoshimi Bando, Mitsunori Sasa, Tadaoki Morimoto, Nobuya Sano, Toshiyuki Hirose and Akira Tangoku : False-positive in fine-needle aspiration cytology of breast disease can be reduced with p63 immunostaining- A preliminary report, Anticancer Research, 26, 6B, 4373-4378, 2006.
(要約)
Myoepithelial cells of the mammary gland are considered to be a key to distinguishing benign from malignant disease in fine-needle aspiration (FNA) cytology. However, identification of these cells with Papanicolaou staining is not easy. The identification of myoepithelial cells was investigated using p63 antibodies to carry out immunostaining of FNA specimens that had been used at the time of Papanicolaou staining for 37 patients who yielded false-positives in FNA. Positively-stained cells were observed in overlying cell clusters or the background in 67.6% of the patients. There is a possibility that over-diagnosis could have been avoided by performing p63 staining for these patients. The controls consisted of stamp samples of fresh specimens obtained from 23 patients at the time of surgery for invasive carcinoma and the results of p63 immunostaining did not reveal any positive staining of tumor cells. Accordingly, these results indicate that there is a strong likelihood that there is no invasive carcinoma when many p63-positive cells are observed in the tumor cell population or the background and that p63 immunostaining has the potential to aid in reducing false-positives at the time of FNA diagnosis of breast disease.
BACKGROUND: A clinical trial of Docetaxel was performed by tri-weekly administration in patients with advanced or recurrent breast cancer. However, careful observation is necessary for outpatients because serious neutropenia often occurs during the therapy. A bi-weekly schedule is recommended since weekly administration requires more visits to the hospital. Docetaxel is proved to express synergistic efficacy in combination with 5'-DFUR by induced dThdPase in vivo. But there are no clinical trials to evaluate efficacy of bi-weekly Docetaxel and 5'-DFUR combination therapy. PURPOSE: To evaluate safety, the recommended dose of Docetaxel and the efficacy of biweekly Docetaxel and 5'-DFUR combination therapy. PATIENTS AND METHODS: Patients with advanced or recurrent breast cancer within 1 regimen of prior chemotherapy and without prior use of both Docetaxel and 5'-DFUR were enrolled. 5'-DFUR was orally administered by 600 mg/day. Docetaxel was intravenously given for at least 2 cycles (8 weeks) by 30 mg/m(2) for level 1, 40 mg/m(2) for level 2 and 50 mg/m(2) for level 3. At each level with 3 cases enrolled,the maximum tolerated dose (MTD) level was defined as that in which 2 or 3 cases showed dose limiting toxicity (DLT). The recommended dose was defined as the dose before MTD level. Therapeutic safety was evaluated by analyses of adverse events with the recommended dose. RESULTS: MTD was in level 3 and the recommended dose of Docetaxel was 40 mg/m(2) of level 2. No DLT was observed in level 2, and this combination therapy seemed safe and feasible for outpatients. In addition, all 6 cases for whom therapeutic efficacy was evaluated expressed a clinical response.
(キーワード)
Administration, Oral / Aged / Ambulatory Care / Antineoplastic Combined Chemotherapy Protocols / Bone Neoplasms / Breast Neoplasms / Dose-Response Relationship, Drug / Drug Administration Schedule / Female / Floxuridine / Humans / Lung Neoplasms / Maximum Tolerated Dose / Middle Aged / Neoplasm Recurrence, Local / Taxoids
(文献検索サイトへのリンク)
● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16770094
In this paper, a new configuration of the electrodes, called divided electrode, is proposed for a short time measurement of bio-impedance in a cross section of a local tissue. Its capability is examined by computer simulations, where a distributed equivalent circuit is used as a model of the tissue. Estimation of impedance parameters is carried out by use of the Gauss-Newton Method. As a result of them, usefulness of the proposed method is confirmed by computer simulations using a typical layered tissue model.
Takako Ichihara, Ayako Tamura, Tuyosi Kataoka, Tadaoki Morimoto, Takako Minagawa and Yumi Kuwamura : Accuracy of tissue thickness of the rectus femoris region as measured by ultrasound, JNI : The Journal of Nursing Investigation, 4, 2, 79-86, 2006.
(要約)
In order to verify the accuracy of the thickness of the rectus femoris muscle and overlying subcutaneous fat as assessed by ultrasound, experiments were conducted on 10 healthy subjects aged over 30 years to assess the following: 1) concordance of measurements made by two different observers; 2) concordance of repeated measurements made by the same observer ; and 3) concordance of repeated measurements made by the same observer with and without an imaging aid(ultrasound gel block). Between two observers with varying experience in ultrasound, no significant difference in measured muscle thickness was observed ; however, there was a significant difference in subcutaneous fat thickness. When measurements were made by the same observer on two separate days, a significant positive correlation was evident for muscle and subcutaneous fat thickness between the first and second tests. While use of the imaging aid was associated with higher concordance of measurements between the first and second tests, the measurements themselves were affected. Although ultrasonic measurement of tissue thickness requires further investigation to minimize intra-observer error and examine correlations with other imaging techniques, the accuracy of the measurements in the present study suggests that clinical application may be possible.
(キーワード)
leg muscle thickness / leg subcutaneous fat thickness / ultrasonography
Takako Ichihara, Tsuyoshi Kataoka, Ayako Tamura, Yukiko Miyakoshi, Yumi Kuwamura, Takako Minagawa and Tadaoki Morimoto : Changes in the thickness of leg muscles before and after laparotomy, Journal of Health Sciences, Hiroshima University, 5, 1, 10-15, 2005.
(要約)
広島保健学学会 特別講演In order to establish an objective and convenient technique to assess postoperative recovery following laparotomy, in particular activities of daily living, we measured the thickness of muscle tissues by ultrasound sonography. In the present study, the following four muscular compartments were selected: rectus femoris, biceps femoris, extensor digitorum longus, and soleus. These account for a large portion of the systemic skeletal musculature and are important for locomotion. Subjects were 28 patients who underwent moderately invasive surgery for stomach or colon cancer. The results showed that muscle thickness decreased significantly in all four compartments. Rectus femoris exhibited the greatest reduction in thickness and was most affected by short-term or long-term recumbency. Furthermore, for soleus, the tendency was that the longer the recumbency, the greater the wasting. These findings suggest that, of the four areas of the lower limb, rectus femoris is most affected by short-term recumbency and is most suited for objectively assessing postoperative recovery. The results of the present study suggest that it would be effective to design a recovery program focused on maintaining the femoral extensor muscles, which are most affected by short-term recumbency following laparotomy.
(キーワード)
leg muscle thickness / ultrasonography / laparotomy
臨地実習での学びを効果的にするために，3年課程3年次学生を対象に臨地実習固有の学習内容を用いた学生自己評価を継続しているが，自己評価得点は，実習開始前から中期にかけて上昇しても，中期から終了時には上昇しない傾向が続いた．そのため，成人看護学臨地実習(急性期)では，2003年度後期に学生の興味・関心のあるテーマを課題学習として導入することを試みた．課題学習を導入した2003年度後期(36人)と導入しなかった2001年度後期(34人)の自己評価得点の差を統計的に検定することにより，課題学習の効果を検討した．その結果，以下の結果が得られた． ① 課題学習のテーマを決定する過程において，学生は，自己の学習状況を振り返り，整理することができた． ② 終了時の自己評価では，課題学習を導入しなかった2001年度では4．0点以上の高得点の項目が20項目であったのに対し，課題学習を導入した2003年度では40項目もあり，学生は学習内容に到達したと高く評価していた． これらのことより，興味・関心のあるテーマを課題学習として導入することは，学生の自発性を高め，学習内容に対する学生の到達度の認識を高める可能性があると考えられた．
Yuken Ohmine, Tadaoki Morimoto, Yohsuke Kinouchi, Tadamitsu Iritani, Mieko Takeuchi, Mari Haku and Hiromu Nishitani : Basic study of new diagnostic modality according to non-invasive measurement of the electrical conductivity of tissues, The Journal of Medical Investigation : JMI, 51, 3,4, 218-225, 2004.
(要約)
The purposes of this study were to estimate the electrical conductivity of tissues by non-invasively measuring the electrical bio-impedance, to develop a new method for tissue diagnosis, i.e., electrical impedance tomography (EIT). Tissue models were first designed taking into consideration the distribution of the fat tissue, muscle and bone in the human forearm, and then the intra-tissue distributions of electrical potential and field, and the electrical impedance in the models was theoretically analyzed by the three-dimensional finite element method. The electrical impedance of both forearms was measured in healthy human subjects, and estimated the electrical conductivity of individual local tissues. The results of the analysis showed that the distributions of electrical potential and field were affected by the presence of fat tissue but not by the presence or absence of bone. In addition, as a result of calculation of the electrical resistance of the extracellular fluid (Re) in each model, it was found that the value of bio-impedance was influenced by the presence of fat tissue, and the value of bio-impedance was increased by the intervention of a fat layer. The electrical conductivity estimated by fitting the observed values to the values obtained by finite element analysis was 0.40 S/m and 0.15 S/m for male muscle and fat tissue, and 0.35 S/m and 0.11 S/m for female muscle and fat tissue, respectively. The sex difference in the slope of linear approximation in the estimation of electrical conductivity of the males and females was thought to be due to sex differences in the properties and structure of fat tissue. These results suggest that local tissues can be diagnosed differentially and electrically by percutaneous measurement of local bio-impedance and subsequent estimation of the electrical conductivity of each tissue.
臨地実習指導における教育的な介入への示唆を得ることを目的に，3年課程短期大学3年次学生を対象に，臨地実習開始前·中期·終了後に，国立大学医療技術短期大学部看護学科協議会臨地実習委員会Aグループが作成した「臨地実習固有の学習内容」を用いて，学生の臨地実習固有の学習内容に対する到達度の認識について，調査を行った．その結果，以下の結果が得られた． ① 自己評価得点は，実習開始前と比べて終了時に自己評価が有意に上昇したもの(以下上昇群)と，上昇しなかったもの(非上昇群)の2群に大きく分類できた． ② 上昇群のうち，段階的に評価が上昇した項目は7項目であった． ③ 学生は，認知領域は高く自己評価し，学習内容に到達したと認識していた． ④ 学生は14項目は終了時に至っても，到達レベルに達していないと自己評価しており，それらの項目は，コミュニケーションや看護過程，理論との照合など看護を深める取り組みに関する内容であった． 以上のことから，教育的な介入として，学生がコミュニケーション技術を有効に用いながら，看護過程を展開し，看護実践を深めることができるように，カンファレンスを有効に活用し，場面を捉えて，学生の学習状況にあわせて，丁寧に指導を行うことが必要であると考えられた．学年進行に伴う到達レベルの詳細な明示など，学生の成長を長期的な視点に立って支援することの必要性が示唆された．
Mari Haku, Mieko Takeuchi, Tadaoki Morimoto, Shuji Yamano and Keiko Takebayashi : Relationship between mammary gland structures during pregnancy and breast-feeding, JNI : The Journal of Nursing Investigation, 2, 1, 16-20, 2004.
(要約)
Study Purpose Diagnostic indices for prediction of breast milk production and assessment of care necessary for mammary gland structure during the pregnancy period were investigated. Methods Development of mammary gland during the pregnancy period was examined via ultrasound methodology. Each subject underwent three measurements once per trimester. Quantity of post-partum breast milk production was also measured ; furthermore, the relationship between mammary gland image and production quantity was evaluated. Results and conclusion As previously reported, mammary gland reaches a certain level of development during the course of pregnancy. Four distinct types of developmental pattern were observed. Mammary gland exhibited remarkable development up to the 15th week of pregnancy in comparison with non-pregnant adult females in type 1. In type 2, mammary gland displayed significant development from the 16th to the 35th week of pregnancy. In types 3 and 4, mammary gland tissue development, which was apparent from 35 weeks, was characterized by gland thickness of > 20 mm and < 20 mm, respectively. Among these four types, type 1 mammary gland demonstrated the largest level of breast milk production. Therefore, we suggest that understanding with respect to mammary gland structure during pregnancy contributes toward individual support in breast-feeding following childbirth.
Xueli Zhao, Yohsuke Kinouchi, Emiko Yasuno, Dayong Gao, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : A New Method for Noninvasive Measurement of Multilayer Tissue Conductivity and Structure Using Divided Electrodes, IEEE Transactions on Biomedical Engineering, 51, 2, 362-370, 2004.
(要約)
This paper outlines a new method for measuring multilayer tissue conductivity and structure by using divided electrodes, in which current electrodes are divided into several parts. Our purpose is to estimate the multilayer tissue structure and the conductivity distribution in a cross section of the local tissue by using bioresistance data measured noninvasively. The effect of the new method is assessed by computer simulations using a typical two-dimensional (2-D) model. In this paper, the conductivity distribution in the model is analyzed based on a finite difference method (FDM) and a steepest descent method (SDM). Simulation results show that the conductivity values of skin, fat, and muscle layers can be estimated with an error of less than 0.1%. When random noise at various levels is added to the measured resistance values, estimates of the conductivity values for skin, fat, and muscle layers are still reasonably precise: their root mean square errors are about 1.06%, 1.39%, and 1.61% for 10% noise. In a 2-D model, increasing the number of divided electrodes permits simultaneous estimates of tissue structure and conductivity distribution. Optimal configuration for divided electrodes is examined in terms of dividing pattern.
Masako Minato, Chieko Hirose, Mitsunori Sasa, Hiroshi Nishitan, Yukiko Hirose and Tadaoki Morimoto : 3-Dimensional Computed Tomography Lymphography-Guided Identification of Sentinel lymph Nodes in Breast Cancer Patients Using Subcutaneous Injection of Nonionic Contrast Medium :A clinical Trial, Journal of Computer Assisted Tomography, 28, 1, 46-51, 2004.
(要約)
Simple and reliable identification methods for sentinel lymph nodes (SLNs) which do not use radioisotope are essential for early breast cancer patients in community hospitals in Japan. The purpose of this paper is to demonstrate the feasibility and efficacy of computed tomography (CT) lymphography for SLN detection. The study included 15 cases with T1 or T2 breast cancer. After subcutaneous injection of 1 mL of iopamidol in 1 subareolar area of the affected breast, CT scanning was carried out and 3-dimensional (3D) CT images were created. SLNs predicted from images and CT values were assessed as to whether they were identical to those identified by the dye method. An enhanced lymph vessel draining into SLN was demonstrated in 11 cases (73%) and an enhanced SLN in 10 cases (67%). 3D images clearly revealed the anatomic relationship between lymph vessels, SLN, and the surrounding structures. In addition, SLN could be predicted by the change of CT value in the time-course in another case. In total, SLN in 13 cases (87%) could be predicted. All SLNs suggested from CT lymphography were identified by the dye method. No significant adverse effect was noted in any case. The present clinical trial indicated that subcutaneous injection of nonionic contrast medium with CT scanning seems to be a promising method for the demonstration of a draining lymph vessel and SLN. The CT value time-course may also provide some important information. Further trials will be needed for the successful establishment of this CT lymphography-guided method for SLN identification.
Tadaoki Morimoto, Ayako Tamura, Takako Ichihara, Takako Minagawa, Yumi Kuwamura, Yoshimi Miki and Mitsunori Sasa : Evaluation of a new rehabilitation program for postoperative patients with breast cancer, Nursing & Health Sciences, 5, 4, 275-282, 2003.
(要約)
The purpose of the present study was to evaluate the efficacy of a newly designed rehabilitation program for postoperative patients with breast cancer. This was achieved through examinations to clarify the range of motion (ROM) of the shoulder joint, postoperative pain and recovery of activities of daily living (ADL). The ROM of the shoulder joint was evaluated with respect to five items and determinations were carried out five times. Patients were orally questioned four times regarding their pain after surgery, movement-associated chest pain, pain at night and operative wound pain. Evaluation of the ADL after discharge was conducted using a three-level rating method at postoperative week 4 and week 12. A total of 72 patients were studied, comprising 39 who underwent pectoral muscle-conserving mastectomy and 33 who underwent breast-conserving surgery. The arm movement of forward raising showed the greatest decline, followed by lateral raising of the arm. Postoperative time-course changes in internal/external arm rotation, as well as backward arm raising were slight. Comparison of the operative procedures revealed differences only for lateral arm raising at postoperative week 4, while there were no differences in any of the shoulder joint movements. Lowering of the ROM of the shoulder joint was more marked at an earlier time (week 1 to week 2) after surgery, but it was not statistically significant. Pain at night and operative wound pain were prolonged over the period, and reported in postoperative week 1 to week 12 by 3-15% of patients. All ADL items became almost normal in approximately 90% of patients at postoperative week 4. The efficacy of the present rehabilitation program early after surgery was demonstrated in terms of recovery of ADL as well as the ROM of the arm on the affected side.
(キーワード)
Activities of Daily Living / Adult / Aged / Breast Neoplasms / Chest Pain / Exercise / Female / Hand Strength / Humans / Mastectomy / Mastectomy, Segmental / Middle Aged / Pectoralis Muscles / Postoperative Period / Program Evaluation / Range of Motion, Articular / Shoulder Joint / Time Factors
Takeshi Tominaga, Hiroki Koyama, Tetsuya Toge, Shigeto Miura, Keizo Sugimachi, Susumu Yamaguchi, Koichi Hirata, Yasumasa Monden, Yasuo Nomura, Masakazu Toi, Izo Kimijima, Shinzaburo Noguchi, Hiroshi Sonoo, Kazuaki Asaishi, Tadashi Ikeda, Tadaoki Morimoto, Jun Ota, Yasuo Ohashi and Osahiko Abe : Randomized Controlled Trial Comparing Oral Doxifluridine Plus Oral Cyclophosphamide With Doxifluridine Alone in Women With Node-Positive Breast Cancer After Primary Surgery, Journal of Clinical Oncology, 21, 6, 991-998, 2003.
(要約)
We compared the therapeutic usefulness of doxifluridine (5'-DFUR) alone and a combination of 5'-DFUR plus cyclophosphamide (CPM), both of which are considered effective against advanced and recurrent breast cancer, to determine which treatment is more beneficial as postoperative adjuvant chemotherapy. A total of 1,131 women with node-positive primary breast cancer were randomly assigned after primary surgery to receive 5'-DFUR alone or 5'-DFUR plus CPM. All patients initially received 5'-DFUR in an oral dose of 1,200 mg/d for 4 weeks, starting 4 weeks after surgery. Chemotherapy was then not given for 2 weeks. Patients in the 5'-DFUR group subsequently received five 4-week cycles of treatment consisting of oral 5'-DFUR (1,200 mg/d) for the first 2 weeks and no chemotherapy for the next 2 weeks. Those assigned to the 5'-DFUR plus CPM group also received oral CPM 100 mg/d for the first 2 weeks and no chemotherapy for the next 2 weeks. Women 50 years or older concurrently received 20 mg/d of tamoxifen for 2 years in both groups. Of the 1,088 eligible women, 546 were assigned to receive 5'-DFUR alone and 542 were assigned to receive 5'-DFUR plus CPM. Overall disease-free survival was significantly better in women who received 5'-DFUR plus CPM than in those who received 5'-DFUR alone (log-rank test, P =.021). Toxic effects occurred in 20.0% of patients (109 of 546) in the 5'-DFUR group and 32.3% of patients (175 of 542) in the 5'-DFUR plus CPM group (chi(2) test, P <.001). Combination therapy with 5'-DFUR plus CPM is more effective in preventing recurrence than 5'-DFUR alone.
術後の健康回復の促進に向けた看護ケアの基礎的資料を得るため,超音波診断装置(周波数は7.5MHz)を用いて,開腹による胃あるいは大腸手術を受けた患者を対象に,手術経過に伴う下肢の筋組織厚および皮下脂肪厚の変化を明らかにした.術前,術後離床日,術後10日目,術後20日目の合計4回,下肢の大腿直筋上,大腿二頭筋上,長指伸筋上,ヒラメ筋上にプローブを当て,組織厚を測定した.開腹による胃または大腸手術を行なった患者のうち,合計4回の測定結果が得られた16名を分析対象とした.4箇所の測定部位の筋組織厚および皮下脂肪厚をそれぞれ合計し,筋組織厚総和および皮下脂肪厚総和を算出し,術前値との比較を行なった.その結果,下肢の筋組織厚総和は,術後離床日,術後10日目,術後20日目に有意な減少を認めた.一方,下肢の皮下脂肪厚総和は,術後には有意な減少を認めず,ほとんど変化しないことが明らかになった.胃手術群と大腸手術群の比較においては,胃手術群は,術後10日目から術後20日目にさらに減少し,回復の傾向を示さなかったが,大腸手術群は,術後10日目から術後20日目に下肢の筋組織厚が回復の傾向を示した.よって,開腹術後患者,特に胃手術患者に対して,より細やかな看護観察と栄養評価,および食事摂取量を増やす看護介入の必要性が示唆された.In order to obtain basic data for use in postoperative nursing care intended to promote the recovery of patients after surgery, the authors examined postoperative changes in lower limb muscular tissue thickness and subcutaneous fat thickness by ultrasonography (7.5 MHz) in patients who underwent open surgery of the stomach or large intestine. The ultrasound probe was placed on the skin above the following muscles: quadriceps femoris, biceps femoris muscle, extensor digitorum longus, and soleus. Measurements were taken on 4 occasions: before surgery, and on the 1st, 10th and 20th day after postoperative mobilization. Of all patients who underwent open surgery of the stomach or large intestine, 16 patients were selected for analysis and ultrasonic measurements. Muscular tissue and subcutaneous fat thicknesses at each of the four sites of measurement were totaled to yield measures of total muscular tissue and total subcutaneous fat. Postoperative and preoperative parameters were then compared. The total lower limb muscular tissue thickness at each of the 4 postoperative measurement points was significantly less than the preoperative thickness, whereas the total lower limb subcutaneous fat thickness showed no significant decrease after surgery and remained almost unchanged from the preoperative value. Comparing patients undergoing different types of surgery, leg muscular tissue thickness showed a tendency to recover on the 10th and 20th day after surgery in the colorectal surgery group, while the gastric surgery group showed further decreases in this parameter on the 10th and 20th day, with no trend towards recovery evident over the timeframe investigated. These results suggest the necessity of active nursing intervention for patients after open gastric surgery.G2
Masako Minato, Chieko Hirose, Mitsunori Sasa, Hiroshi Nishitan, A. HORI and Tadaoki Morimoto : Axillary 3D CT Imaging with Lymphoscintigraphy Is Useful for Sentinel Node Biopsy in Breast Cancer, Anticancer Research, 23, 3C, 2935-2940, 2003.
(要約)
This study examined whether 3D CT imaging with lymphoscintigraphy (LSG) is useful when performing sentinel node biopsy (SNB) in a community hospital where radioisotope with gamma-probe (RI method) is unavailable. From June to November 2002, 35 T1/T2 clinically node-negative breast cancer patients underwent LSG in a university nuclear medicine department. Skin areas above LSG hot spots were marked, helical CT scanning was performed and axillary 3D images were created in our hospital. The SLN predicted from the 3D images were examined for agreement with the dye method. SLNs were detected with dye in 32 out of 35 patients (91.4%). In 31 of those 32 (96.9%), the SLN predicted from 3D CT images was the same. Even in the 3 dye-negative patients, CT imaging predicted the SLN. SNB including sampling was successful in 34 patients (97.1%). 3D CT imaging with LSG enables SNB even if the RI method is impossible.
Xueli Zhao, Yohsuke Kinouchi, Emiko Yasuno, Dayong Gao, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : A New Method for Non-Invasive Measurement of Multi-layer Tissue Conductivity and Structure Using Divided Electrodes, IEEE Transactions on Biomedical Engineering, 1, 11, 1-10, 2002.
Xueli Zhao, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : Estimation of Multi-Layer Tissue Conductivities from Non-invasively Measured Bioresistances Using Divided Electrodes, IEICE Transactions on Information and Systems, E85-D, 6, 1031-1038, 2002.
(要約)
To estimate inner multi-layer tissue conductivity distribution in a cross section of the local tissue by using bioresistance data measured noninvasively on the surface of the tissue, a measurement method using divided electrodes is proposed, where a current electrode is divided into several parts. The method is evaluated by computer simulations using a three-dimension (3D) model and two two-dimension (2D) models. In this paper, conductivity distributions of the simplified (2D) model are analyzed based on a combination of a finite difference method (FDM) and a steepest descent method (SDM). Simulation results show that conductivity values for skin, fat and muscle layers can be estimated with an error less than 0.1%. Even though different strength random noise is added to measured resistance values, the conductivities are estimated with reasonable precise, e.g., the average error is about 4.25% for 10% noise. The configuration of the divided electrodes are examined in terms of dividing pattern and the size of surrounding guard electrodes to confine and control the input currents from the divided electrodes within a cross sectional area in the tissue.
Haiying Zhao, Tadaoki Morimoto, Mitsunori Sasa and Keisuke Izumi : An immunohistochemical evaluation of biomarkers and apoptotic cells in ductal carcinoma in situ of breast, Breast Cancer, 9, 2, 118-126, 2002.
Takeshi Tominaga, Masakazu Toi, Osahiko Abe, Yasuo Ohashi, Junichi Uchino, Hiroshi Hayasaka, Rikiya Abe, Masaru Izuo, Kohji Enomoto, Hiromu Watanabe, Minoru Yoshida, Tetsuo Taguchi, Hiroki Koyama, Tsuneaki Senoo, Tetsuya Toge, Yasumasa Monden, Takao Hattori, Yasuo Nomura, Keizo Sugimachi, Koichi Hirata, Hiroaki Nakazato, Shigeto Miura, Tadaoki Morimoto, Kazuaki Asaishi, Izo Kimijima, Jun Ota, Hiroshi Sonoo and Susumu Yamaguchi : The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: Results from a multicenter randomized controlled trial, International Journal of Oncology, 20, 3, 517-525, 2002.
(要約)
To assess the efficacy of 5'-DFUR, an intermediate of capecitabine, for adjuvant treatment of early breast cancer, we conducted an open-labeled multi-center randomized controlled trial to compare postoperative 5'-DFUR treatment with surgery alone. We enrolled 1217 primary breast cancer patients and randomly assigned them into two treatment groups; one received six-month postoperative 5'-DFUR treatment by consecutive or intermittent administration, and the other surgery alone. Follow-up surveys were conducted once a year for all subjects simultaneously and examined their outcome/presence or absence of the cancer recurrence. The central study committee reviewed all follow-up data and judged the recurrence data to be used for the analysis. Eight-year follow-up data showed no significant differences in relapse-free and overall survival between the two groups, and 5'-DFUR treatment regimen showed an extremely high tolerance. Possible explanations are discussed for the finding of no significant survival difference between adjuvant 6-month 5'-DFUR monotherapy and surgery alone in early breast cancer.
Haiying Zhao, Tadaoki Morimoto, Mitsunori Sasa, Yutaka Asato and Keisuke Izumi : Cases Report of Malignant Mucocele-like Lesions, Breast Cancer, 9, 1, 86-90, 2002.
(要約)
Mucocele-like lesions (MLL) of the breast have been reported as extremely rare as well as benign, but now it is believed they can be both malignant and benign. This paper describes two cases of malignant MLL, both subjected to immunohistochemical staining. Case 1: A 42-year-old woman with multiple malignant MLLs without evidence of a mass at presentation to our hospital after biopsy, but whose ultrasonogram showed small multiple hypoechoic lesions. Case 2: A 70-year-old woman, whose left breast cancer was found on routine mammography after modified radical mastectomy for right breast cancer. Pathologically, MLL with intraductal carcinoma was diagnosed. Case 1 underwent two lumpectomies in 3 years, but even now new lesions have developed. However, the patient refused to have another operation. C-erbB2 was negative in both cases. When malignant MLL is histologically of low grade, excisional biopsy is sufficient for a single MLL with intraductal carcinoma, while it may be necessary to perform a subcutaneous mastectomy for multiple lesions.
T tominaga, H koyama, Y Nomura, S Miura and Tadaoki Morimoto : Primary breast cancer patients treated with breast-conserving therapy and tamoxifen, --- - Do they always require radiotherapy? - ---, Clin Dru Invest, 21, 11, 775-782, 2001.
Tadaoki Morimoto, Mitsunori Sasa, Tetsuo Yamaguchi, Hiroyuki Kondo and Yasunobu Sagara : Breast cancer screening with mammography in women aged under 50 years in Japan, Anticancer Research, 20, 5C, 3689-3694, 2000.
(要約)
BACKGROUND: The effectiveness of mammographic screening in women aged over 50 years has been confirmed in the United States and Europe, but its effectiveness in women aged from 40 to 49 years remains controversial. The optimum age for effective screening of subjects for breast cancer by mammography in Japan was studied based on the results of mammographic screening. METHOD: The benefit of breast cancer screening in women was examined by stratifying the results of mammographic screening in a Tokushima trial on the basis of age: under 50 years and 50 years or older. The results of conventional screening by physical examination alone, which we performed in a Zentsuji trial, were used as the control. RESULTS: The examinees numbered 13,982 and 18,619 in mammographic screening and screening by physical examination, respectively. Breast cancer was detected in 43 and 22 patients, respectively. The detection rate of breast cancer was 0.31% by mammographic screening, which is about 3 times higher than that (0.12%) by screening using physical examination. Mammographic screening thus showed significantly higher sensitivity (93.5% vs 73.3%, p = 0.015). The proportion of stage I cancer and the absence of nodal involvement were 67.4% and 79.1% by mammographic screening, compared with 31.8% and 59% by physical examination. Our results obtained with mammographic screening were equal to or higher than the results obtained in the United States and Europe. The clinical stage of the breast cancers detected by mammographic screening in the subjects aged under 50 years was stage 0 (DCIS) in one case and stage I in 10 cases, while the group aged 50 years or older showed stage 0 in 11 cases and stage I in 19 cases. There were three cases of false-negative; two false-negative cases were aged under 50 year, while one case was aged 50 years or older. The detection rates of cancer in the group under 50 years and that of 50 years or more were 0.19% and 0.39% by mammograpic screening and 0.09% and 0.15% by the physical examination. The sensitivities in the group under 50 years and that of 50 years or more were 84.6% and 97.0% by mammographic screening and 72.7% and 73.7% by physical examination, showing no significant difference. In the results of mammograms by Wolfe's classification with respect to the age groups, the proportion of DY (dense breast) pattern decreased significantly from 3.5% to 0.2% in women of 50 years or more and from 16.6% to 2.4% in those under 50 years when the values were compared between the period from 1992 to 1995 and the period from 1998 to 1999, respectively (p < 0.0001). CONCLUSION: The above findings suggested the possible effectiveness of mammographic screening not only in women aged 50 years or more but also in those aged under 50 years, in Japan. Therefore, introduction of mammography should be considered at an early date, even for women aged from 40 to 49 years.
(キーワード)
乳癌 (breast cancer) / mammograohic screening / under 50 years / early detection / screening sensitivity
(文献検索サイトへのリンク)
● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11268440
Yumi Kuwamura, Tadaoki Morimoto, Ayako Tamura, Takako Ichihara, Takako Minagawa, Kanako Katai, Mari Haku, Mieko Takeuchi and Toshiko Tada : Temperature effect of a disinfectant in operative field during surgery under local anesthesia, Nursing & Health Sciences, 2, 4, 205-210, 2000.
Yasuhiro Kaneda, Akira Fujii, Takashi Yamaoka, Tadaoki Morimoto and Isao Nagamine : Neither gynecomastia nor galactorrhea is a common side effect of neuroleptics in male patients, Neuroendocrinology Letters, 21, 6, 447-451, 2000.
(要約)
OBJECTIVE: Gynecomastia is known to be a side effect of neuroleptics. The authors investigated the prevalence of gynecomastia and galactorrhea in a group of regularly neuroleptic-treated male patients. METHODS: Gynecomastia was defined as a palpable, discrete button of firm subareolar tissue measuring at least 2 cm in diameter. The subjects were 100 male patients who were taking neuroleptic treatment regularly. Each patient gave informed consent for the research involved in this study. RESULTS: (1) Palpable gynecomastia was present in 2% of the patient group, but not at all in the normal group. (2) Galactorrhea was not present in either patient or normal group. (3) The mean level of the serum prolactin in the group of patients without gynecomastia (n = 53) was significantly higher than that in the normal group (n = 35), but there was no significant difference in blood luteinizing hormone, follicle-stimulating hormone, testosterone (T), estradiol (E(2)) or T/E(2) ratio between the groups. (4) The mean level of the T/E(2) ratio in the patients with gynecomastia tended to be higher than that in the group of patients without gynecomastia. CONCLUSIONS: Overall, these results seem to indicate that (i) gynecomastia is not common in the Japanese population, and (ii) in male patients neither palpable gynecomastia nor galactorrhea is a common side effect of neuroleptics. To clarify the relation between gynecomastia and neuroleptic treatment, large prospective studies are required.
Yuuken Oomine, Tadaoki Morimoto, Yohsuke Kinouchi, Tadamitsu Iritani, Mieko Takeuchi and Yasumasa Monden : Noninvasive Measurement of the Electrical Bioimpedance of Breast Tumors, Anticancer Research, 20, 3B, 1941-1946, 2000.
(要約)
The purpose of this study was to evaluate the possibility of differential diagnosis of tumors, such as breast cancer, by measuring the mammary electrical bioimpedance via the skin surface noninvasively and by examining the relationship between the tissue structure of the breast and electrical bioimpedance. The mammary electrical bioimpedance was measured in 24 patients with breast cancer. Taking into account the measurement results and the distribution of the mammary glands and fatty tissue, a breast model with tumors was proposed. Based on this model, the distributions of the electric potential and electric field in the tissue were theoretically analyzed by the three-dimensional finite element method. In clinical cases, the Re values of the diseased breast were significantly larger than those of the contralateral healthy breast. In theoretical analysis based on the breast model, the Re value of mammary electrical bioimpedance varied due to the structure of the breast, that is, the ratio of fatty tissue to mammary gland and the presence of mammary tumors. The results of the measurement agreed with the theoretical analyses. These results suggest that differential diagnosis of breast tumors is possible by measuring the mammary electrical bioimpedance using noninvasive electrodes on the skin.
(キーワード)
Adipose Tissue / Breast / Breast Diseases / Breast Neoplasms / Computer Simulation / Diagnosis, Differential / Electric Impedance / Electrodiagnosis / Female / Galvanic Skin Response / Humans / Models, Theoretical
(文献検索サイトへのリンク)
● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10928131
Yingyan Yu, Tadaoki Morimoto, Mitsunori Sasa, Kuniyasu Okazaki, Yosuke Harada and Tsutomu Fujiwara : Human papillomavirus type 33 DNA in breast cancer in Chinese, Breast Cancer, 7, 1, 33-36, 2000.
(要約)
The association between human papillomavirus (HPV) and anogenital tumors, especially cervical cancer, is well documented. However, it remains unclear whether there is also a correlation between HPV infection and human breast cancer. We used PCR and Southern blot hybridization to analyze HPV-related DNA specimens from 32 cases of invasive ductal carcinoma operated upon in the Shanghai region of China. DNA derived from HPV33 was detected in 14 cases (43.8%). No HPV16 or HPV18 DNA was detected in any of the cases in this study. This is the first report demonstrating a correlation between HPV33 infection and breast cancer. Our results suggest that HPV33 infection may be involved in the pathogenesis of breast cancer in Chinese.
Yingyan Yu1, Tadaoki Morimoto, Mitsunori Sasa, Kuniyasu Okazaki, Yosuke Harada, Tsutomu Fujiwara, Yasuo Irie, Ei-ichi Takahashi, Akira Tanigami and Keisuke Izumi : HPV33 DNA in premalignant and malignant breast lesions in Chinese and Japanese populations., Anticancer Research, 19, 6B, 5057-5061, 1999.
(要約)
The relationship between human papillomavirus (HPV) infection and breast cancer is controversial. In this study, paraffin-embedded tissue blocks prepared from 72 patients with benign, premalignant or malignant mammary lesions were randomly collected from the Shanghai region of China and Tokushima in Japan. DNA specimens extracted from all tissues were amplified by the polymerase chain reaction (PCR) using HPV16, 18 and 33 primers. Southern blot hybridization showed 19 cases to be positive for HPV33 DNA: The positive rate for HPV33 DNA in Chinese (41.7%) was significantly higher than in Japanese (11.1%) (P < 0.01): The positive rate for HPV33 DNA in invasive ductal carcinoma (34.1%) was higher than in benign or borderline mammary lesions (5%) (P < 0.02). There were no statistically significant difference among the relationship of the nuclear grade of breast cancers with HPV33 DNA-positivity. This is the first report of a positive correlation between HPV33 DNA and breast lesions in Chinese and Japanese populations. These results suggest that the infection by HPV33, but not HPV 16 or HPV 18, may be involved in breast hyperplastic lesions, especially breast cancer, in humans.
(キーワード)
Adult / Aged / Aged, 80 and over / Base Sequence / Breast Neoplasms / China / DNA Primers / DNA, Viral / Female / Humans / Japan / Middle Aged / Papillomaviridae / Polymerase Chain Reaction / Precancerous Conditions
(文献検索サイトへのリンク)
● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10697510
Toshiko Tada, Tadaoki Morimoto and Yamamoto Sumiko : Characteristics of the Daily Lives of Elderly Women at Various facilities for the Aged: Analysis of their ADL and Degree of Satisfaction, Nursing & Health Sciences, 1, 1, 13-18, 1999.
(要約)
A number of studies have been conducted about support for the daily lives of elderly individuals that will elevate their quality of life (QOL). Services provided to support these individuals have also become more diverse. This study will attempt to add to the understanding of QOL for the elderly by comparing levels of dependence and QOL of elderly women in four different types of institution. Individuals who were over 65 years of age and who were able to participate in a 1 h interview were chosen for this study. The subjects were selected from the elderly population of a hospital for aged patients, health service facilities for the elderly, a nursing home and a general hospital. Levels of dependency of activities of daily living (ADL) were measured using the Kahoku Aging Longitudinal Study Scale. The scale qualitatively evaluates the cognition and activities of the elderly. Each measure is rated on a four point scale. Quality of life was measured using the visual analogue scale. Elderly women living at the nursing home differed from those living in the other facilities in regard to their degree of independence in ADL and QOL. These findings indicate that there were differences in the characteristics of the daily lives of elderly women at different types of facilities.
Hitoshi Miki, Hiroyuki Inoue, Kansei Komaki, Tadashi Uyama, Tadaoki Morimoto and Yasumasa Monden : Value of mass screening for thyroid cancer, World Journal of Surgery, 22, 1, 99-102, 1998.
(要約)
This study aims to clarify the presently uncertain value of mass screening for thyroid cancer, which has been performed by physical examination along with mass screening for breast cancer in Zentsuji, Japan since 1983. Among 18,619 subjects, 36 individuals with thyroid cancer (0.19%) were found. The detection rate was 0.40% at the initial screening and 0.10% during subsequent periodic screening. All thyroid cancers were confirmed histologically as well differentiated carcinoma. The tumor size in the mass-screening group (14 +/- 6 mm) was significantly smaller than in patients presenting at an outpatient clinic during the same period (19 +/- 13 mm) (p < 0.05). The incidence of nodal metastases in the mass-screening group (38%) was significantly lower than in the outpatient group (68%) (p < 0.05). Thus mass screening seemed to find thyroid cancers in a relatively early stage. Mass screening for thyroid cancer was economic in this instance because it was performed together with screening for other cancers, such as breast cancer. Thyroid cancer screening required less than one additional minute per subject. The ultimate aim of mass screening is to reduce mortality. No improvement in prognosis from enforced mass screening for thyroid cancer was detected in this study. It cannot be demonstrated that there is sufficient value of mass screening for thyroid cancer to perform it independently despite early cancer detection.
(キーワード)
Adult / Female / Humans / Male / Mass Screening / Middle Aged / Thyroid Neoplasms
(文献検索サイトへのリンク)
● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9465769
Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Shigeru Ohyama : Fast in vivo measurements of local tissue impedances using needle electrodes, Medical and Biological Engineering and Computing, 35, 5, 486-492, 1997.
(要約)
The objective of the research is to show an in vivo, fast method of measurement of local tissue bio-impedance in the beta dispersion region (0-200 kHz). A needle electrode is used for the purpose. The performances with respect to circuits, electrodes, measurement area and electrical representations are evaluated. A measurement example is shown, and the electrical representations are discussed and compared using it. The method discussed, although invasive, is considered to be useful for local tissue diagnoses concerning structures and physiological functions.
Tadaoki Morimoto, Sasa Mitsunori, Tetsuo Yamaguchi, Hiroyuki Kondo, Yasunobu Sagara, Yumi Kuwamura, Sumiko Yamamoto and Toshiko Tada : Effectiveness of mammographic screening for brest cancer in women aged over 50 years in Japan, Japanese Journal of Cancer Research, 88, 8, 778-784, 1997.
(要約)
The optimal age for effective screening of subjects for breast cancer by mammography in Japan was studied based on the results of two mammographic screening systems (systems I and II) in Tokushima Prefecture. System I consisted of visit screening using a bus equipped with a mammographic apparatus. System II consisted of central screening performed at Tokushima Health Screening Center. The examinees numbered 2,500 and 3,707 in systems I and II, respectively. There was a significant difference between the two screening systems in the age distribution of the examinees. The detection rates of breast cancer were 0.6% and 0.24% in systems I and II, respectively, which are 2-5 times higher than that (0.12%) obtained by conventional screening using physical examination alone. The detection rate increased especially in the sixth and seventh decades of life. The sensitivity of mammography screening was 93.3% in system I and 81.1% in system II. Higher sensitivity (100%) than that (73%) of screening by physical examination was obtained in women aged over 50. The proportion of stage I was 60% in system I and 66.7% in system II, compared with 32-65% in the United States and Europe. The rates of no nodal involvement were high, being 77.8% and 83.3% in systems I and II, respectively, compared with 57-71% in other countries. Breast-conserving therapy was applied to 18 of the 24 patients with breast cancer detected by the two screening systems. In addition, in Wolfe's classification of mammograms, the proportion of DY (mammary dysplasia) pattern was remarkably low, being 3.2% in the sixth decade and 0.8% in the seventh decade, compared with 16.6% in women aged 49 years. These results indicate that mammographic screening is effective in women aged over 50 years in Japan, as has been found in other countries.
H Blaszyk, A Hartmann, Y Tamura, S Saitoh, JM Cunningham, RM McGovern, JJ Schroeder, DJ Schaid, K Ii, Y Monden, Tadaoki Morimoto, Kansei Komaki, M Sasa, K Hirata, M Okazaki, JS Kovach and SS Sommer : Molecular epidemiology of breast cancers in northern and southern Japan: the frequency, clustering, and patterns of p53 gene mutations differ among these two low-risk populations, Oncogene, 13, 10, 2159-2166, 1996.
(要約)
Comparison of acquired mutations in the p53 tumor suppressor gene can illuminate factors contributing to carcinogenesis among cancer cohorts. Japan has an ethnically homogeneous population with a low incidence of breast cancer. Previously we reported an unusual frequency, allelic status, and clustering of mutations in breast cancers from the northern part of the main Japanese island. To extend these findings, exons 2-11 and adjacent intronic sequences were analysed in tumors of women from northern (Hokkaido) and southern (Tokushima) Japan. The frequency of breast cancers with p53 gene mutations in the Hokkaido group is the highest reported (81%) while that in Tokushima (28%) is similar to most other populations. Thirteen of the 19 mutations (68.4%) in the Hokkaido cohort were heterozygous, an unusually high frequency for p53 mutations in any tumor type. There were three missense mutations at codon 175, a known hotspot for alterations in the p53 gene, and three missense mutations at codon 179, a rare site for p53 changes. In addition, the patterns of p53 gene mutation differed between the two Japanese cohorts (P=0.04). The multiple differences in acquired p53 mutations suggest unsuspected biological differences among breast cancers in northern and southern Japan. In addition, the high frequency of p53 mutations in breast cancers from Hokkaido predicted a poorer prognosis for this population which was confirmed on examination of mortality data.
(キーワード)
Japan / molecular epidemiology / p53 / 乳癌 (breast cancer)
(文献検索サイトへのリンク)
● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8950983
Takashi Yamakawa, Mitsuaki Shinotoh, Toshikatsu Taniki, Osamu Yasuda, Masaki Hamagaki, Kan Kondoh, Akiyosi Yamamoto, Satoshi Mumoto, Sueyoshi Itoh, Mitsunori Sasa and Tadaoki Morimoto : Ductal Carcinoma In Situ of the Breast: Is Breast Conserving Treatment Feasible?, Breast Cancer, 3, 2, 119-123, 1996.
(キーワード)
乳癌 (breast cancer) / Ductal carcinoma in siru / Extention of cancer / Mammography / Breast conserving treatment
59.
Tadaoki Morimoto, Michio Ogawa, Kunzo Orita, Keizo Sugimachi, Tetsuya Toge, Kiyohiko Dohi, Yasuo Nomura, Yasumasa Monden and Nobuya Ogawa : Postoperative adjuvant randomized trial comparing chemoendocrine therapy, chemotherapy and immunotherapy for patients with stageII breast cancer, --- 5-year results from The Nishinihon cooperative study group of Adjuvant Chemoendocrine Therapy for Breast Cancer (ACETBC) of Japan ---, European Journal of Cancer, 32A, 2, 235-242, 1996.
(要約)
Between 1985 and 1988, the effect of using ftorafur (FT) or PSK (an immunotherapy agent) in combination with the conventional postoperative adjuvant therapy using mitomycin (MMC) plus tamoxifen (TAM) was assessed in stage II, oestrogen receptor-positive (ER+) breast cancer patients. Furthermore, in ER- breast cancer stage II patients, the effects of postoperative adjuvant therapy using MMC plus FT were compared with the effects of postoperative adjuvant therapy using MMC plus PSK. Patients had primary stage II breast cancer and had undergone total mastectomy plus axillary dissection or more radical surgery. On the day of surgery, MMC (13 mg/m2) was administered intravenously. Then, ER+ patients received one of three regimens of drug therapy, starting 2 weeks after surgery: regimen A (daily oral treatment with 30 mg of TAM), regimen B (daily oral treatment with 30 mg of TAM and 600 mg of FT) or regimen C (daily oral treatment with 30 mg of TAM and 3 g of PSK) [corrected]. ER- patients received either regimen D (daily oral treatment with 600 mg of FT) or regimen E (daily oral treatment with 3 g of PSK), starting 2 weeks after surgery. Of the 540 ER+ patients registered, 525 were evaluated. The 5-year overall survival rate for ER+ patients was higher for patients who received regimen B (94.2%) than for those who received regimen A (86.9%) or regimen C (89.9%) (P = 0.063). The 5-year relapse-free survival rate was higher for regimen B (88.9%) than for regimen A (78.6%) and regimen C (77.2%) (P = 0.010). Stratified analysis revealed better results with the FT-combined therapy in patients positive for lymph node metastasis and premenopausal patients. These results indicate the effectiveness of using FT in combination with TAM. Of the 376 ER- patients registered, 364 were evaluated. The 5-year overall and relapse-free survival rate for ER- patients did not differ significantly between patients who received regimen D and those who received regimen E.
Takashi Yamakawa, Mitsuaki Shinotoh, Toshikatsu Taniki, Osamu Yasuda, Masaki Hamagaki, Kan Kondoh, Akiyosi Yamamoto, Satoshi Mumoto, Sueyoshi Itoh, Mitsunori Sasa and Tadaoki Morimoto : carcinoma in situ of the breast, --- Is breast conserving treatmart feasible ? ---, Breast Cancer, 3, 2, 119-123, 1996.
61.
Takashi Tanaka, Tadaoki Morimoto, Yohsuke Kinouchi, Tadamitsu Iritani and Yasumasa Monden : An experimental study of conductive heating using a concentric double-electrode applicator, Research in Experimental Medicine, 195, 5, 255-264, 1995.
62.
Yasunori Konishi, Tadaoki Morimoto, Yohsuke Kinouchi, Tadamitsu Iritani and Yasumasa Monden : Electrical properties of extracted rat liver tissue, Research in Experimental Medicine, 195, 4, 183-192, 1995.
63.
Takashi Yamakawa, Tadaoki Morimoto, Mitsunori Sasa, Satoshi Numoto and Yasumasa Monden : High positive rate of pS2 expression in forefront intraductal cancerous area in breast cancer, Japanese Journal of Cancer Research, 86, 11, 1035-1040, 1995.
Kansei Komaki, Yoshitaka Kamamura, Yuken Ohmime, Mitsunori Sasa, Hiroyuki Inoue, Katsuhiro Tanaka, Tadashi Uyama, Tadaoki Morimoto and Yasumasa Monden : Difference in thymidylate synthetase activity in involved nodes compared with primary tumor in breast cancer patients, Breast Cancer, 35, 2, 157-162, 1995.
(キーワード)
human breast tissue / 乳癌 (breast cancer) / thymidylate synthetase / nodal metastasis / mitosis
65.
Tadaoki Morimoto, Mitsunori Sasa, Kunio Ii, Hideo Tsuzuki, Yoshitaka Kamamura, Kansei Komaki, Tadashi Uyama and Yasumasa Monden : A Malignant Phyllodes Tumor of the Breast in a 6-Year Old Girl, Breast Cancer, 2, 1, 71-75, 1995.
(キーワード)
breast / estrogen receptor / phyllodes tumor / PCNA
66.
Tadaoki Morimoto, Mitsunori Sasa, Tetsuo Yamaguchi, Kunihiko Harada and Yasunobu Sagara : A Comparison of Mass Screening for Breast Cancer Using Mammography and Physical Examination Alone in Japan, Breast Cancer, 2, 1, 19-25, 1995.
(キーワード)
mass screening / 乳癌 (breast cancer) / early detection / mammography
67.
Tadaoki Morimoto, Mitsunori Sasa, Tetsuo Yamaguchi, Kunihiko Harada and Yasunobu Sagara : High detection rate of breast cancer by mass screening using mammography in Japan, Japanese Journal of Cancer Research, 85, 12, 1193-1195, 1994.
(キーワード)
mass screening / 乳癌 (breast cancer) / mammmography / early detection / detection rate
68.
Suguru Kimura, Tadaoki Morimoto, Tadashi Uyama, Yasumasa Monden, Yohsuke Kinouchi and Tadamitsu Iritani : Application of electrical impedance analysis for diagnosis of a pulmonary mass, Chest, 105, 6, 1679-1682, 1994.
69.
Mitsunori Sasa, Kazuya Kondo, Kansei Komaki, Tadaoki Morimoto and Yasumasa Monden : p53 alteration correlates with negative ER, negative PgR, and high histologic grade in breast cancer., Journal of Surgical Oncology, 56, 1, 46-50, 1994.
(要約)
Seventy tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the RT-PCR-SSCP method. Sixty-five samples (92.9%) were investigated in the regions of codons 101-200 and 201-300. In total, 16 samples (24.6%) showed p53 gene alteration. We found that p53 gene alteration showed a correlation with (1) a negative ER status, (2) a negative PgR status, and (3) a high histologic grade (especially numerous mitotic figures) of the tumor. However, we found no correlation between p53 gene alteration and the lymph node status or clinical stage. Thus, p53 gene alteration in breast cancer may occur in highly malignant breast cancer other than advanced clinical stage cancer or node-positive cancer.
Mitsunori Sasa, Kansei Komaki, Tadaoki Morimoto, Toshiaki Mori, Hitoshi Miki, Tadashi Uyama and Yasumasa Monden : Significant Correlation between the Presence of Type W Collagen in the Duct Wall and the Development of Wide Intraductal Cancerous Extension in Breast Cancer, Breast Cancer, 1, 1, 31-36, 1994.
M Sasa, Kazuya Kondo, K Komaki, T Uyama, Tadaoki Morimoto and Yasumasa Monden : Frequency of spontaneous p53 mutations (CpG site) in breast cancer in Japan., Breast Cancer Research and Treatment, 27, 3, 247-252, 1993.
(要約)
Sixty-five tumors of invasive ductal carcinoma of the breast were examined for p53 alteration by the reverse transcription-polymerase chain reaction-single strand conformation polymorphism (RT-PCR-SSCP) method and sequencing analysis. In total, 16 samples (24.6%) showed p53 gene alteration. Sixteen of these alterations were evaluated by sequencing analysis, and 15 showed missense point mutations while one showed a 9-base pair deletion. In the 15 point mutations, G:C to A:T transitions constituted the majority (53%), and five tumors (33%) had a transition at the CpG site, which are mutational patterns not commonly found in breast tumors from Europe and America. On the other hand, there were no G:C to T:A transversions in our cases, which were frequently observed transversions in Europe and America. These p53 mutation patterns in breast cancer in Japan are not similar to those in Europe and America reported by Hollstein et al. and Coles et al.. These findings suggest that there are some differences between mechanisms of breast cancer in Japan and in Europe and America.
(キーワード)
Adult / Aged / Base Sequence / Breast Neoplasms / Female / Genes, p53 / Humans / Middle Aged / Molecular Sequence Data / Mutation / Polymerase Chain Reaction
(文献検索サイトへのリンク)
● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8312582
Hiroyuki Inoue, Kazushi Oshimo, Hitoshi Miki, Muneo Kawano, Kansei Komaki, Yasumasa Monden, Tadaoki Morimoto and Masaru Tsuyuguchi : Immunohistochemical study of estrogen receptor and estradiol on papillary thyroid carcinoma in young patients, Journal of Surgical Oncology, 53, 4, 226-230, 1993.
(キーワード)
thyroid cancer / estrogen receptor / estradiol / young patient / childhood / ER-D5
75.
Hitoshi Miki, Kazushi Oshimo, Hiroyuki Inoue, Muneo Kawano, Katsuhiro Tanaka, Kansei Komaki, Tadashi Uyama, Yasumasa Monden and Tadaoki Morimoto : Incidence of ultrasonographically-detected thyroid nodules in healthy adults, The Tokushima Journal of Experimental Medicine, 40, 1-2, 43-46, 1993.
(キーワード)
thyroid disease / ultrasonography / goiter
76.
Takao Yokoe, Tsunehiro Ishida, Suketami Tominaga, Tetsuo Kuroishi, Tadaoki Morimoto, Hideya Tashiro, Sueyoshi Itoh, Rikiya Abe, Jun Ota, Toshio Horino, Tetsuo Taguchi, Kazuyoshi Honda, Michizou Sasakawa, Yoshitomo Kashiki, Satoru Yamamoto, Kohji Enomoto, Masami Ogita, Koichi Yoshida, Choichiro Kido, Mamoru Fukuda, Hiromu Watanabe and Masaru Izuo : Effect of mass screening for breast cancer from the aspect of psychosocial assessment of the quality of life, Japanese Journal of Cancer Research, 84, 4, 365-370, 1993.
(キーワード)
乳癌 (breast cancer) / mass screening / 生活の質 (quality of life) / psychosocial assessment
77.
Tadaoki Morimoto, Suguru Kimura, Yasunori Konishi, Kansei Komaki, Tadashi Uyama, Yasumasa Monden, Yohsuke Kinouchi and Tadamitsu Iritani : A study of the electrical bioimpedance of tumors, Journal of Investigative Surgery, 6, 1, 25-32, 1993.
(要約)
A new system of impedance measurement over a frequency range of 0 to 200 kHz was developed by a three-electrode method. In this study, the electrical impedances of various tumors were measured in vivo in 54 patients with breast disease (31 breast cancers, 13 fibroadenomas, and 10 fibrocystic diseases) and 57 patients with pulmonary disease (44 lung cancers, 5 metastatic pulmonary tumors, 4 pulmonary tuberculoses, and 4 organized pneumonias). On the basis of those impedance measurements and the equivalent circuits in vivo, we calculated the extracellular resistance (Re), intracellular fluid resistance (Ri), and cell membrane capacitance (Cm) in tissues, all of which were compared among the various diseases. It was found that Re and Ri were significantly higher in breast cancers than in benign tumors and normal breast tissues and that Cm was significantly lower in breast cancers than in other tissues. On the other hand, Re and Ri were significantly higher, and Cm was significantly lower, in normal lung tissues than in pulmonary masses. Re and Ri were significantly higher, and Cm was significantly lower, in malignant tumors than in organized pneumonias. The results showed that these parameters (Re, Ri, and Cm) exhibit significant differences among various tissues and tumors, suggesting possible applications in tumor diagnosis.
(キーワード)
breast tumor / diagnostic modality / 生体電気インピーダンス (electrical bioimpedance) / in vivo / lung tumor
(文献検索サイトへのリンク)
● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8452822
Tadaoki Morimoto, Takashi Tanaka, Kansei Komaki, Mitsunori Sasa, Yasumasa Monden, Hisajiro Kumagai and Hisashi Otsuka : The coexistence of lobular carcinoma in a fibroadenoma with a malignant phyllodes tumor in the opposite breast: report of a case, Surgery Today, 23, 7, 656-660, 1993.
(キーワード)
breast tumor / lobular carcinoma / fibroadenoma / phyllodes tumor
Tadaoki Morimoto, Kansei Komaki, Toshiaki Mori, Mitsunori Sasa, Kazushi Oshimo, Hitoshi Miki, Yasumasa Monden, Kozo Inui, Nobuo Saoyama and Hiiru Yoshida : The quality of mass screening for breast cancer by physical examination, Surgery Today, 23, 3, 200-204, 1993.
Tadaoki Morimoto, Kansei Komaki, Kazushi Oshimo, Hitoshi Miki, Mitsunori Sasa, Toshiaki Mori, Hideo Tsuzuki, Yoshitaka Kamamura and Yasumasa Monden : The characteristics of interval breast cancer in mass screening, The Tokushima Journal of Experimental Medicine, 39, 3-4, 109-116, 1992.
(キーワード)
乳癌 (breast cancer) / Mass screening / Interval cancer / Histological grading / Tumor doubling time
83.
Takesada Mori, Hideo Inaji, Hiroki Koyama, Rikiya Abe, Mitsuhiro Nihei, Masaru Izuo, Tetsuo Ogawa, Koji Enomoto, Hironobu Sato, Fujio Kasumi, Goi Sakamoto, Masujiro Makita, Shigeto Miura, Osamu Kojima, Keisuke Miyauchi, Akira Wada, Eiji Yayoi, Yuichi Takatsuka, Tadaoki Morimoto, Kansei Komaki, Yasuhiko Miyauchi, Michitsugu Sato and Takashi Kudo : Evaluation of an improved dot-immunobinding assay for carcinoembryonic antigen determination in nipple discharge in early breast cancer: results of a multicenter study, Japanese Journal of Clinical Oncology, 22, 6, 371-376, 1992.
(要約)
We have previously reported carcinoembryonic antigen (CEA) measurement in nipple discharge to be a useful adjunct in the diagnosis of non-palpable breast cancer. We have now developed a "microdot-immunobinding assay" using a specially constructed device to screen efficiently large numbers of patients with nipple discharge for non-palpable breast cancer. The method is as follows: a sample of nipple discharge is placed on a solid phase monoclonal anti-CEA antibody and, if CEA is present in the discharge, it will be detected by a second monoclonal anti-CEA antibody conjugated with alkaline phosphatase. The use of bromochloroindolyl phosphate as a chromogen results in a stable color reaction that can be semiquantitatively analyzed with the naked eye. CEA levels determined by this microdot assay correlated well with those determined using the earlier Elmotec assay. To determine the accuracy of the method, a collaborative study involving 11 institutes in Japan was organized. The CEA levels in nipple discharges from 77 patients undergoing surgery, 44 of whom were diagnosed as having breast cancer, were assayed. The results were that 17 of the 23 patients with palpable breast cancer, and 16 of the 21 patients with non-palpable breast cancer exhibited CEA values > 400 ng/ml, a cut-off value determined in a previous study. The overall accuracy (78%) of this test for diagnosing non-palpable breast cancer was higher than that obtained from ductography or cytology. The system may thus be of use in the screening of early breast cancer.
Masakazu Toi, Takao Hattori, Masanobu Akazi, Kiyoshi Inokuchi, Kunzo Orita, Keizo Sugimachi, Kiyohiko Dohi, Yasuo Nomura, Yasumasa Monden, Yuzo Hamada, Tadaoki Morimoto and Nobuya Ogawa : Randomized adjuvant trial to evaluate the addition of tamoxifen and PSK to chemotherapy in patients with primary breast cancer. 5-Year results from the Nishi-Nippon Group of the Adjuvant Chemoendocrine Therapy for Breast Cancer Organization, Cancer, 70, 10, 2475-2483, 1992.
Hitoshi Miki, Kazushi Oshimo, Hiroyuki Inoue, Muneo Kawano, Tadaoki Morimoto and Yasumasa Monden : Estimated weight of the residual parathyroid gland after parathyroidectomy Surgery using plasma levels of parathyroid hormone, Surgery Today, 22, 3, 196-200, 1992.
(キーワード)
secondary hyperparathyroidism / weight of the parathyroid / parathyroid hormone
86.
Tetsuo Kuroishi, Suketami Tominaga, Jun Ota, Toshio Horino, Tetsuo Taguchi, Tsunehiro Ishida, Takao Yokoe, Masaru Izuo, Masami Ogita, Sueyoshi Itoh, Rikiya Abe, Koichi Yoshida, Tadaoki Morimoto, Kohji Enomoto, Hideya Tashiro, Yoshitomo Kashiki, Satoru Yamamoto, Choichiro Kido, Kazuyoshi Honda, Michizou Sasakawa, Mamoru Fukuda and Hiromu Watanabe : The effect of breast self-examination on early detection and survival, Japanese Journal of Cancer Research, 83, 4, 344-350, 1992.
Hitoshi Miki, Kazushi Oshimo, Hiroyuki Inoue, Muneo Kawano, Tadaoki Morimoto, Yasumasa Monden, Yosuke Yamamoto and Seizo Kita : Thyroid carcinoma in patients with secondary hyperparathyroidism, Journal of Surgical Oncology, 49, 3, 168-171, 1992.
(キーワード)
thyroid cancer / hemodialysis / parathyroidectomy / parathyroid hormone
88.
Yasuo Nomura, Shigeto Miura, Hiroki Koyama, Kohji Enomoto, Fujio Kasumi, Hiroshi Yamamoto, Masahara Kimura, Takeshi Tominaga, Hirokazu Iino, Tadaoki Morimoto and Hideya Tashiro : Relative effect of steroid hormone receptors on the prognosis of patients with operable breast cancer. A univariate and multivariate analysis of 3089 Japanese patients with breast cancer from the Study Group for the Japanese Breast Cancer Society on Hormone Receptors and Prognosis in Breast Cancer, Cancer, 69, 1, 153-164, 1992.
adult T-cell lymphoma / breast / extranodal lymphoma
90.
Kansei Komaki, Tadaoki Morimoto, Toshiaki Mori, Mitsunori Sasa, Kazushi Oshimo, Yasumasa Monden, Takanori Hirose and Kazuo Hizawa : A rare case of fibroadenoma in a tubular adenoma of the breast, Surgery Today, 22, 2, 163-165, 1992.
(キーワード)
tubular adenoma / fibroadenoma / breast adenoma
91.
Toshiaki Mori, Tadaoki Morimoto, Kansei Komaki and Yasumasa Monden : Comparison of estrogen receptor and epidermal growth factor receptor content of primary and involved nodes in human breast cancer, Cancer, 68, 3, 532-537, 1991.
92.
Kansei Komaki, Toshiaki Mori, Tadaoki Morimoto, Mitsunori Sasa, Yasumasa Monden and Kunio Ii : Correlation between estrogen receptor status and histological malignancy in human breast cancer, Journal of Surgical Oncology, 46, 3, 185-189, 1991.
(キーワード)
immunocytochemical assay / histological differentiation / age / staining intensity index
93.
Kansei Komaki, Goi Sakamoto, Haruo Sugano, Fujio Kasumi, Susumu Watanabe, Itsumasa Nishi, Tadaoki Morimoto and Yasumasa Monden : The morphological feature of mucus leakage appearing in low papillary carcinoma of the breast, Human Pathology, 22, 3, 231-236, 1991.
(要約)
This report summarizes the clinicopathologic findings in 11 cases of low papillary carcinoma of the breast accompanied by the morphologic feature of mucus leakage into the mammary stroma. These cases were characterized by two morphologic findings. First, abundant mucus produced by the tumor cells filled the intraductal spaces where neoplastic epithelium formed very low papillary projections, ie, a feature of mucinous-producing low papillary carcinoma in situ. Second, there was expansive leakage of mucus into the mammary stroma occasionally accompanied by a few epithelial cells. All the cases showed a high level of mucus production and contained no elements of invasive ductal carcinoma or ordinary invasive mucinous carcinoma. These cases have no evidence of direct invasion of the mammary stroma by malignant cells. The average age of the 11 patients was 41 years. Foci of microcalcification were seen in some tumors (seven cases; 64%). There were no cases with lymph node metastases. All the patients underwent mastectomy with no adjuvant therapy, and they are currently alive and well.
Tetsuo Kuroishi, Suketami Tominaga, Jun Ota, Toshio Horino, Tetsuo Taguchi, Tsunehiro Ishida, Takao Yokoe, Masaru Izuo, Masami Ogita, Sueyoshi Itoh, Rikiya Abe, Koichi Yoshida, Tadaoki Morimoto, Kohji Enomoto, Hideya Tashiro, Yoshitomo Kashiki, Choichiro Kido, Kazuyosi Honda, Michizou Sasakawa, Mamoru Fukuda and Hiromu Watanabe : The effect of mass screening for breast cancer: results of a multivariate analysis, Japanese Journal of Cancer Research, 82, 1, 27-32, 1991.
(キーワード)
breast cancer screening / matched paer analysis / multivariate analysis / prognosis / Life-prolonging effect
95.
Koichi Yoshida, Rikiya Abe, Sueyoshi Itoh, Tetsuo Taguchi, Jun Ota, Tadaoki Morimoto, Tsunehiro Ishida, Hideya Tashiro, Masami Ogita, Choichiro Kido, Yoshitomo Kashiki, Tetsuo Kuroishi and Suketami Tominaga : Comparisons of interval breast cancers with other breast cancers detected through mass screening and in outpatient clinics in Japan, Japanese Journal of Clinical Oncology, 20, 4, 374-379, 1990.
(要約)
In a nation-wide collaborative study on mass screening for breast cancer, we collected 152 cases of interval breast cancer diagnosed at 35 hospitals or clinics distributed throughout Japan. The definition of interval breast cancer used in the present study is "breast cancer cases which were diagnosed as having 'no malignant findings' in a previous screening for breast cancer but subsequently diagnosed as 'breast cancer' at a hospital or medical clinic within two years of the previous screening." The clinical stages and prognoses of these interval cancer were analyzed and compared with those of other breast cancers detected through mass screening and in outpatient clinics. In the clinical staging of interval breast cancer, Tis (non infiltrating cancer) accounted for only 2.1%, compared to 8.0% in cases detected through mass screening. At stage I 43.4% were interval breast cancers compared to 32.9% breast cancers detected through mass screening and 25.4% diagnosed in outpatient clinics. The stage differences between interval breast cancers and breast cancers detected through mass screening were not statistically significant. Five-year survival rates were 85.6% for interval breast cancers, 91.7% for breast cancers detected through mass screening and 84.7% for breast cancers diagnosed in outpatient clinics. Ten-year survival rates were 75.9, 80.5 and 78.1%, respectively, suggesting the interval breast cancer cases to show a similar prognosis to that of breast cancer cases diagnosed in outpatient clinics. The differences in five- and 10-year survival rates among the three groups were not statistically significant. From the present study we were not able to confirm the general belief of interval cancer being more aggressive in nature and showing a poorer prognosis than cancer detected through periodic screening. The reasons for this are discussed.
(キーワード)
乳癌 (breast cancer) / mass screening / interval breast cancer / clinical stage / prognosis
(文献検索サイトへのリンク)
● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 2283721
Tadaoki Morimoto, Hiroyuki Yamamoto, Kansei Komaki, Yasunori Konishi, Takashi Tanaka, Takashi Yamakawa, Toshiaki Mori, Mitsunori Sasa and Monden Yasumasa : Chemoendocrine therapy in DMBA-induced rat mammary carcinoma, The Tokushima Journal of Experimental Medicine, 37, 3-4, 59-68, 1990.
(キーワード)
DMBA-induced rat mammary carcinoma / 5-fluorouracil / tamoxifen / Rat
97.
Hitoshi Miki, Kazushi Oshimo, Hiroyuki Inoue, Tadaoki Morimoto and Yasumasa Monden : Sex hormone receptors in human thyroid tissues, Cancer, 66, 8, 1759-1762, 1990.
98.
Tadaoki Morimoto, Kansei Komaki, Takashi Yanakawa, Takashi Tanaka, Yuken Oomine, Yasunori Konishi, Toshiaki Mori and Yasumasa Monden : Cancer of the male breast, Journal of Surgical Oncology, 44, 3, 180-184, 1990.
(キーワード)
histological malignancy / hormone receptor
99.
Tetsuo Kuroishi, Suketami Tominaga, Tadaoki Morimoto, Hideya Tashiro, Sueyoshi Itoh, Hiromu Watanabe, Mamoru Fukuda, Jun Ota, Tosio Horino, Tsunehiro Ishida, Takao Yokoe, Koji Enomoto, Yoshitomo Kashiki and Masami Ogita : Tumor growth rate and prognosis of breast cancer mainly detected by mass screening, Japanese Journal of Cancer Research, 81, 5, 454-462, 1990.
(キーワード)
乳癌 (breast cancer) / Natural history / Tumor growth rate / Prognosis / Doubling time
100.
Tadaoki Morimoto, Yosuke Kinouchi, Tadamitsu Iritani, Suguru Kimura, Yasunori Konishi, Nanretsu Mitsuyama, Kansei Komaki and Yasumasa Monden : Measurement of the electrical bio-impedance of breast tumors, European surgical research, 22, 2, 86-92, 1990.
(キーワード)
Electrical bio-impedance / Breast tumor / Diagnostic modality / Measurement in vivo
101.
Jun Ohta, Toshio Horino, Tetsuo Taguchi, Tsunehiro Ishida, Masaru lzuo, Masami Ogita, Rikiya Abe, Hiromu Watanahe, Tadaoki Morimoto, Sueyoshi Itoh, Hideya Tashiro, Koichi Yoshida, Kazuyoshi Honda, Michizou Sasakawa, Koji Enomoto, Yoshitomo Kashiki, Choichiro Kido, Tefsu Kuroishi and Suketani Tominaga : Mass screening for breast cancer: comparison of the clinical stages and prognosis of breast cancer detected by mass screening and in out-patient clinics, Japanese Journal of Cancer Research, 80, 11, 1028-1034, 1989.
(キーワード)
乳癌 (breast cancer) / Mass screening / early detection / matched pair analysis / breast self-examination
102.
Yasumasa Monden, Tadaoki Morimoto, Toshikatsu Taniki, Tadashi Uyana and Suguru Kimura : Flexible bronchoscopy for foreign body in airway, The Tokushima Journal of Experimental Medicine, 36, 1-2, 35-39, 1989.
(キーワード)
foreign body / airway / flexible bronchoscopy / children / Fogarty catheter / ventilation
103.
Tadaoki Morimoto, Kansei Komaki, Hiroyuki Yamamoto, Takashi Yamakawa, Takashi Tanaka, Hiroshi Sonoo and Yasumasa Monden : Prognostic value of hormone receptors in breast cancer, Journal of Surgical Oncology, 39, 2, 101-107, 1988.
Kozo Inui, Tadaoki Morimoto, Kansei Komaki, Hiroshi Sonoo and Yasumasa Monden : Changes in the hormone dependency of DMBA-induced rat mammary tumors with reference to the effect of tamoxifen, The Japanese Journal of Surgery, 18, 3, 284-290, 1988.
(要約)
Tamoxifen was administered over a period of 4 weeks to 19 female Sprague-Dawley rats bearing 20 DMBA-induced mammary tumors. Consequently, 13 tumors (65.0 per cent) regressed and showed a reduction in their estradiol receptor (ER) and progesterone receptor (PgR) concentrations. In spite of subsequent treatment given to the rats bearing the regressed tumors, 6 new tumors occurred. The ER and PgR concentrations of these tumors were lower than those of the tumors before tamoxifen therapy, and histochemical study showed these tumors to be composed mostly of ER-negative cells. These results suggest that: (a) the hormone dependency of breast cancer is reduced by tamoxifen therapy; (b) breast cancers recurring during tamoxifen therapy show reduced hormone dependency.
Kansei Komaki, Goi Sakanoto, Haruo Sugano, Tadaoki Morimoto and Yasumasa Monden : Mucinous carcinoma of the breast in Japan. A prognostic analysis based on morphologic features, Cancer, 61, 5, 989-996, 1988.
107.
Tadaoki Morimoto, Kansei Komaki, Kazushi Oshiro, Takashi Yamakawa, Nanretsu Mitsnyana, Takashi Tanaka and Yasumasa Monden : Breast cancer detected by mass screening using physical examination alone, The Japanese Journal of Surgery, 17, 5, 377-381, 1987.
(キーワード)
乳癌 (breast cancer) / mass screening / physical examination / interval cancer / breast self-examination
108.
Tadaoki Morimoto, Kansei Komaki, Kozo Inui, Atsushi Unemoto, Hiroyuki Yamamoto, Kunihiko Harada and Kenji Inoue : Involvement of nipple and areola in early breast cancer, Cancer, 55, 10, 2459-2463, 1985.
109.
Tadaoki Morimoto, Kansei Komaki, Kozo Inui, Kenichi Nishimoto, Hiroshi Sonoo, Kunihiko Harada and Kenji Inoue : Minor surgery for early cancer of the breast--from the clinicopathological study--, The Tokushima Journal of Experimental Medicine, 30, 1-2, 1-7, 1983.
(キーワード)
乳癌 (breast cancer) / Early stage / Multi sliced specimen / Cancerous extension / Minor surgery
110.
Kenji Inoue, Tadaoki Morimoto, Hiroshi Sonoo, Yasushi Koshiba, Muneo Kitamura, Etsuo Kakuta and Haruo Fujiwara : An evaluation of mass screening for breast cancer, The Japanese journal of surgery, 11, 1, 22-26, 1981.
Takao Hattori, Minoru Niimoto, Akira Nakano, Eiji Itagaki, Kenji Inoue and Tadaoki Morimoto : Biopsy of the breast, The Japanese journal of surgery, 10, 4, 270-276, 1980.
Kunio Ii, Kazuo Hizawa, Kuniyasu Okazaki, Tadaoki Morimoto and Yukihisa Uyama : Liposarcoma of the breast--fine structural and histochemical study of a case and review of 42 cases in the literature, The Tokushima Journal of Experimental Medicine, 27, 3-4, 45-56, 1980.
113.
Kenji Inoue, Kuniyasu Okazaki, Tadaoki Morimoto, Masami Hayashi, Yukihisa Uyama, Hiroshi Sonoo, Yasushi Koshiba, Tetsuichi Takihara, Yasuo Nomura, Jun Yamagata, Hideaki Kondo, Kazuhiro Kanda and Kenji Takenaka : Therapeutic value of mepitiostane in the treatment of advanced breast cancer, Cancer treatment reports, 62, 5, 743-745, 1978.
Tadaoki Morimoto, Masatoshi Okazaki and Tokiko Endo : Current Status and Goals of Mammographic Screening for Breast Cancer in Japan, Breast Cancer, 11, 1, 73-81, Jan. 2004.
(要約)
In Europe and the United States, the proportion of women receiving mammographic screening for breast cancer has increased to 60-80%, resulting in an increase in the detection of early-stage cancer and a reduction in the mortality rate. The objectives of breast cancer screening have thus already been achieved there. In Japan, both the incidence and mortality of breast cancer have increased recently. Breast cancer screening has long been performed by clinical breast examination (CBE) alone. A reduction in the mortality of breast cancer cannot be expected from CBE. Mammographic screening for breast cancer was recommended in a notification issued by Ministry of Health, Labour and Welfare in 1999. An important aspect of mammographic screening is quality control. The Central Committee on Quality Control of Mammographic Screening(Central Committee)was organized by six screening-related societies, and attempts have since been made to establish a quality control system. Both the social recognition of the Central Committee and its cooperation with the "Quality Control Committee " of each community will become important. The cover rate of nationwide breast cancer screening by CBE alone is 12-13%, while the implementation rate of mammographic screening is presently very low and its cover rate is considered to be about 2%. With such a low cover rate, it is absolutely impossible to reduce the mortality of breast cancer. To achieve this, the administration and clinicians will be required to cooperate with each other to increase the spread and cover rate of high-quality mammographic screening.
(キーワード)
乳癌 (breast cancer) / Mortality reduction / Mammographic screening / Quality control system / Central committee
Tadaoki Morimoto and Mitsunori Sasa : Current Status of Screening for Breast Cancer and Tasks for Introduction of Mammographic Screening in Japan, Breast Cancer, 5, 3, 227-234, 1998.
国際会議:
1.
Emiko Yasuno, Xueli Zhao, Yohsuke Kinouchi, Tadaoki Morimoto, Akira Tangoku, Okazaki Kenji, Ikeda Yuichi, Sato Yasuhiro and Ichida Teruhiro : A fundamental study on theory of space distribution estimation for EIT, Proceedings of the International Symposium on Biological and Physiological Engineering /The 22nd SICE Symposium on Biological and Physiological Engineering, 353-354, Harbin, Jan. 2008.
(キーワード)
bio-impedance / tissue equivalent circuit model / Gauss-Newton metohd
2.
Teruhiro Ichida, Yuichi Ikeda, Emiko Yasuno, Kenji Okazaki, Yasuhiro Sato, Akira Tangoku, Yohsuke Kinouchi and Tadaoki Morimoto : Improvement of bio-impedance measurement accuracy with guard electrodes approach, International journal of bioelectromagnetism, 9, 1, 126-127, Aizuwakamatsu, Oct. 2007.
3.
Ikeda Yuichi, Sato Yasuhiro, Yohsuke Kinouchi, Emiko Yasuno, Omine Yuken, Akira Tangoku and Tadaoki Morimoto : Nomivasive Estimation of Tissue Impedance Based on an Equivalent Circuit Model, Proceedings of the Intenational Conference on Biomedical and Pharmaceutical Engineering, 246-251, Singapore, Dec. 2006.
4.
Arisa Morimoto, Emiko Yasuno, Yohsuke Kinouchi, Y Omine, Akira Tangoku and Tadaoki Morimoto : Spatial Resolution in the Electrical Impedance Tomography for the Local Tissue, Proceedings of the 27th Annual Conference of the IEEE-EMBS, 7, 6638-6641, Shanghai, Sep. 2005.
Emiko Yasuno, Kato Hiromi, Yohsuke Kinouchi and Tadaoki Morimoto : A Fundamental Study on Parameter Estimation of Layerd Local Tissue Impedance for EIT, Proceedings of the 27th Annual Conference of the IEEE-EMBS, 7, 6650-6653, Shanghai, Sep. 2005.
Morimoto Arisa, Kato Hiromi, Emiko Yasuno, Yohsuke Kinouchi and Tadaoki Morimoto : Theoretical study on local tissue EIT and its spatial resolution, 6th Asian-Pacific Conference on Medical and Biological Engineering(APCMBE2005), Tsukuba, Apr. 2005.
7.
Hiromi Kato, Emiko Yasuno, Yohsuke Kinouchi and Tadaoki Morimoto : Electrical Impedance Tomography for Local Biological Tissue, Proceedings of 8th International Conference on Control, Automation, Robotics and Vision, 942-946, Kunming, Dec. 2004.
(要約)
Electrical impedance tomography (EIT) is 2-D or 3-D image of electrical impedance distribution in a living tissue. It has become expected as a different method to obtain a tissue characteristic for various medical diagnoses. To realize a practical EIT measurement system, it is an important subject to choose a proper configuration of the electrodes, because the EIT is estimated from impedance data, which is measured non-invasively by surface electrodes. In this study, a new configuration of the electrodes, called divided electrode, is proposed for a short time measurement of bio-impedance in a cross section of a local tissue. Its capability is examined by computer simulations, where a distributed equivalent circuit is used as a model in the cross section of the tissue. Estimation of impedance parameters is carried out by use of the Newton Method. Usefulness of the proposed method is confirmed by computer simulations using a typical layered tissue model.
Emiko Yasuno, Xueli Zhao, Yohsuke Kinouchi, Tadaoki Morimoto, Mieko Takeuchi and Yuuken Oomine : Parameter Estimation of the Local Tissue Impedance by Using Divided Electrode for EIT, 2004 RISP International Workshop on Nonlinear Circuits and Signal Processing, 379-382, Honolulu, Mar. 2004.
9.
Hiroyuki Bando, Emiko Yasuno, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : A New Method for Estimating Bioimpedance Distribution in a Local Tissue Using Divided Electrodes - Towards Local EIT, Proceedings of World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia, August 24-29, 2003, MO.TR1-38, Sydney, Aug. 2003.
10.
Kenji Izukura, Xueli Zhao, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : A New Method of Electrical Impedance Tomography for Conductivity Distribution in Multi-layer Local Tissue from Non-invasively Measured Bioresistances, international Congress on Biological and Medical Engineering Programme&Handbook, 132, Singapore, Dec. 2002.
11.
Yumi Komai, Emiko Yasuno, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : Theoretical Studies on Electrical Impedance Tomography Based on Equivalent Circuits for the Local Tissue by Use of a Divided Ilectrode, international Congress on Biological and Medical Engineering Programme&Handbook, 50, Singapore, Dec. 2002.
12.
Xueli Zhao, Yohsuke Kinouchi, Tadamitsu Iritani, Tadaoki Morimoto and Mieko Takeuchi : Estimation of Conductivity Distribution in the Local Tissue Using a Divided Electrode, Proceedings of The International Technical Conference on Circuits/Systems, Computers and Communications, 2, 1262-1267, Tokushima, Jul. 2001.
13.
Yasuhiro Kaneda, Tadaoki Morimoto and Akira Fujii : Effects of tandospirone on the hypothalamo-pituitary-gonadal axis of male patients, Scientific Meeting of the Pacific Rim College of Psychiatrists, Seoul, Oct. 1999.
14.
Risuke Kojima, Xueli Zhao, Yohsuke Kinouchi, Tadamitsu Iritani and Tadaoki Morimoto : Parameter Estimation of Distributed Equivalent Circuits for the Tissue, Proceedings of The 4th Asia-Pacific Conference on Medical and Biological Engineering, 451, Seoul, Sep. 1999.
15.
Norihide Momose, Yohsuke Kinouchi, Tadamitsu Iritani, Y Konishi, Tadaoki Morimoto and I Kato : Three dimensional analysis of local tissue impedance by finite element method, Medical & Biological Engineering & Computing, 35, Suppl. Part 1, 347, Nice, France, Sep. 1997.
16.
Yohsuke Kinouchi, Emiko Fujimoto and Tadaoki Morimoto : Equivalent distributed circuits for bioimpedance of nonuniform tissue, Medical and Biological Engineering and Computing, 35, Suppl. Part 1, 347, Nice, France, Sep. 1997.
Ikeda Yuichi, Sato Yasuhiro, Ichida Teruhiro, Emiko Yasuno, Yohsuke Kinouchi, Okazaki Kenji, Akira Tangoku and Tadaoki Morimoto : Development of Noninvasive Bio-impedance Measuring Method for Breast Cancer Diagnosis, Journal of Shikoku-Section Joint Convention of the Institutes of Electrical and Related Engineers, 398, Sep. 2007.