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Tokushima University > Research Clusters > Research Clusters (Registered) > 1704091 細胞内代謝に焦点をあてたシェーグレン症候群の新規治療薬の開発 >
Tokushima University > Research Clusters > Research Clusters (Selected) > 1903001 次世代型「脳関門創薬」拠点形成:ヒト血液脳関門物流システム解明に基づく脳関門突破型抗体・核酸医薬の開発(立川正憲) >
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Research Activity

Field of Study

Cell Biology, Biochemistry

Subject of Study

Phosphoproteome analysis of signal transduction pathways, 核膜孔複合体の翻訳後修飾による核—細胞質間物質輸送などの細胞機能の制御

Book / Paper

Book:

1. Wendell Lim(著), Bruce Mayer(著), Tony Pawson(著), 西田 栄介(監訳) and Hidetaka Kosako :
細胞のシグナル伝達, 第9章,
メディカル・サイエンス・インターナショナル, Tokyo, May 2016.
2. Hidetaka Kosako and 後藤 由季子 :
タンパク質のリン酸化,
朝倉書店, Jul. 2008.
3. Kaori Matsuzawa, Hidetaka Kosako, Ichiro Azuma, Naoyuki Inagaki and Masaki Inagaki :
Possible regulation of intermediate filament proteins by Rho-binding kinases.,
Plenum Press, 1998.

Academic Paper (Judged Full Paper):

1. Izumi Ohigashi, Yu Tanaka, Kenta Kondou, Sayumi Fujimori, Hiroyuki Kondo, Amy Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako and Yousuke Takahama :
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.,
Cell Reports, Vol.29, No.9, 2901-2916.e6, 2019.
(DOI: 10.1016/j.celrep.2019.10.079,   PubMed: 31775054)
2. Takuya Yokoyama, Masaki Yukuhiro, Yuka Iwasaki, Chika Tanaka, Kazunari Sankoda, Risa Fujiwara, Atsushi Shibuta, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Kazumasa Yoshida, Nozomi Sugimoto, Hiroyuki Morimoto, Hidetaka Kosako, Takashi Ohshima and Masatoshi Fujita :
Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10,
Scientific Reports, Vol.9, No.1, 16825, 2019.
(DOI: 10.1038/s41598-019-53259-2,   PubMed: 31727981)
3. Hiroya Yamazaki, Hidetaka Kosako and Shige H Yoshimura :
Quantitative proteomics indicate a strong correlation of mitotic phospho-/dephosphorylation with non-structured regions of substrates,
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2019.
(DOI: 10.1016/j.bbapap.2019.140295,   PubMed: 31676455)
4. Takumi Koshiba and Hidetaka Kosako :
Mass spectrometry-based methods for analyzing the mitochondrial interactome in mammalian cells.,
The Journal of Biochemistry, 2019.
(DOI: 10.1093/jb/mvz090,   PubMed: 31647556)
5. Fumika Koyano, Koji Yamano, Hidetaka Kosako, Yoko Kimura, Mayumi Kimura, Yukiko Fujiki, Keiji Tanaka and Noriyuki Matsuda :
Parkin-mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes.,
EMBO Reports, 2019.
(DOI: 10.15252/embr.201947728,   PubMed: 31602805)
6. Takahiro Yoshinaka, Hidetaka Kosako, Takuma Yoshizumi, Ryo Furukawa, Yu Hirano, Osamu Kuge, Taro Tamada and Takumi Koshiba :
Structural Basis of Mitochondrial Scaffolds by Prohibitin Complexes: Insight into a Role of the Coiled-Coil Region,
iScience, Vol.27, No.19, 1065-1078, 2019.
(DOI: 10.1016/j.isci.2019.08.056,   PubMed: 31522117)
7. Fumika Koyano, Koji Yamano, Hidetaka Kosako, Keiji Tanaka and Noriyuki Matsuda :
Parkin recruitment to impaired mitochondria for nonselective ubiquitylation is facilitated by MITOL,
The Journal of Biological Chemistry, Vol.294, No.26, 10300-10314, 2019.
(DOI: 10.1074/jbc.RA118.006302,   PubMed: 31110043)
8. Yuichi Takashi, Hidetaka Kosako, Shun Sawatsubashi, Yuka Kinoshita, Nobuaki Ito, Maria K. Tsoumpra, Masaomi Nangaku, Masahiro Abe, Munehide Matsuhisa, Shigeaki Kato, Toshio Matsumoto and Seiji Fukumoto :
Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation,
Proceedings of the National Academy of Sciences of the United States of America, Vol.116, No.23, 11418-11427, 2019.
(Tokushima University Institutional Repository: 113621,   DOI: 10.1073/pnas.1815166116,   PubMed: 31097591)
9. Takaharu Sakuragi, Hidetaka Kosako and Shigekazu Nagata :
Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure,
Proceedings of the National Academy of Sciences of the United States of America, Vol.116, No.8, 2907-2912, 2019.
(DOI: 10.1073/pnas.1820499116,   PubMed: 30718401,   Elsevier: Scopus)
10. Kou Motani and Hidetaka Kosako :
Phosphoproteomic identification and functional characterization of protein kinase substrates by 2D-DIGE and Phos-tag PAGE,
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol.1867, 57-61, 2019.
(DOI: 10.1016/j.bbapap.2018.06.002,   PubMed: 29883688)
11. Takeshi Terabayashi, Katsuhiro Hanada, Kou Motani, Hidetaka Kosako, Mami Yamaoka, Toshihide Kimura and Toshimasa Ishizaki :
Baicalein disturbs the morphological plasticity and motility of breast adenocarcinoma cells depending on the tumor microenvironment,
Genes to Cells, Vol.23, No.6, 466-479, 2018.
(DOI: 10.1111/gtc.12584,   PubMed: 29667279,   Elsevier: Scopus)
12. Kou Motani and Hidetaka Kosako :
Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.,
The Journal of Biological Chemistry, Vol.293, No.20, 7717-7726, 2018.
(DOI: 10.1074/jbc.RA118.002175,   PubMed: 29618514,   Elsevier: Scopus)
13. Miyuki Sato, Katsuya Sato, Kotone Tomura, Hidetaka Kosako and Ken Sato :
The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans,
Nature Cell Biology, Vol.20, No.1, 81-91, 2018.
(DOI: 10.1038/s41556-017-0008-9,   PubMed: 29255173,   Elsevier: Scopus)
14. Hidetaka Kosako and Kou Motani :
Global Identification of ERK Substrates by Phosphoproteomics Based on IMAC and 2D-DIGE,
Methods in Molecular Biology, Vol.1487, 137-149, 2017.
(DOI: 10.1007/978-1-4939-6424-6_10,   Elsevier: Scopus)
15. Eri Ishikawa, Hidetaka Kosako, Tomoharu Yasuda, Masaki Ohmuraya, Kimi Araki, Tomohiro Kurosaki, Takashi Saito and Sho Yamasaki :
Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1.,
Nature Communications, Vol.7, 12756, 2016.
(Tokushima University Institutional Repository: 112446,   DOI: 10.1038/ncomms12756,   PubMed: 27670070)
16. Shiori Akabane, Midori Uno, Naoki Tani, Shunta Shimazaki, Natsumi Ebara, Hiroki Kato, Hidetaka Kosako and Toshihiko Oka :
PKA regulates PINK1 stability and Parkin recruitment to damaged mitochondria through phosphorylation of MIC60.,
Molecular Cell, Vol.62, No.3, 371-384, 2016.
(DOI: 10.1016/j.molcel.2016.03.037,   PubMed: 27153535,   Elsevier: Scopus)
17. Yuki Shindo, Kazunari Iwamoto, Kazunari Mouri, Kayo Hibino, Masaru Tomita, Hidetaka Kosako, Yasushi Sako and Koichi Takahashi :
Conversion of graded phosphorylation into switch-like nuclear translocation via autoregulatory mechanisms in ERK signalling,
Nature Communications, Vol.7, 10485, 2016.
(Tokushima University Institutional Repository: 112432,   DOI: 10.1038/ncomms10485,   PubMed: 26786866,   Elsevier: Scopus)
18. Kei Okatsu, Fumika Koyano, Mayumi Kimura, Hidetaka Kosako, Yasushi Saeki, Keiji Tanaka and Noriyuki Matsuda :
Phosphorylated ubiquitin chain is the genuine Parkin receptor,
The Journal of Cell Biology, Vol.209, No.1, 111-128, 2015.
(DOI: 10.1083/jcb.201410050,   PubMed: 25847540,   Elsevier: Scopus)
19. Fumika Koyano, Kei Okatsu, Hidetaka Kosako, Yasushi Tamura, Etsu Go, Mayumi Kimura, Yoko Kimura, Hikaru Tsuchiya, Hidehito Yoshihara, Takatsugu Hirokawa, Toshiya Endo, Fon A. Edward, Trempe Jean-Francois, Saeki Yasushi, Keiji Tanaka and Noriyuki Matsuda :
Ubiquitin is phosphorylated by PINK1 to activate Parkin.,
Nature, Vol.510, No.7503, 162-166, 2014.
(DOI: 10.1038/nature13392,   PubMed: 24784582,   Elsevier: Scopus)
20. Haruko Tsurumi, Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Kenji Hayashi, Atsuko Matsunaga, Yuko Kajiho, Shoichiro Kanda, Kenichiro Miura, Takashi Sekine, Akira Oka, Kiyonobu Ishizuka, Shigeru Horita, Motoshi Hattori, Seisuke Hattori and Takashi Igarashi :
Epithelial protein lost in neoplasm modulates platelet-derived growth factor-mediated adhesion and motility of mesangial cells.,
Kidney International, Vol.86, No.3, 548-557, 2014.
(DOI: 10.1038/ki.2014.85,   PubMed: 24694988,   Elsevier: Scopus)
21. Masahiro Iguchi, Yuki Kujuro, Kei Okatsu, Fumika Koyano, Hidetaka Kosako, Mayumi Kimura, Norihiro Suzuki, Shinichiro Uchiyama, Keiji Tanaka and Noriyuki Matsuda :
Parkin-catalyzed ubiquitin-ester transfer is triggered by PINK1-dependent phosphorylation.,
The Journal of Biological Chemistry, Vol.288, No.30, 22019-22032, 2013.
(DOI: 10.1074/jbc.M113.467530,   PubMed: 23754282,   Elsevier: Scopus)
22. Michio Nakaya, Mitsuru Tajima, Hidetaka Kosako, Takeo Nakaya, Akiko Hashimoto, Kenji Watari, Hiroaki Nishihara, Mina Ohba, Shiori Komiya, Naoki Tani, Motohiro Nishida, Hisaaki Taniguchi, Yoji Sato, Mitsuru Matsumoto, Makoto Tsuda, Masahiko Kuroda, Kazuhide Inoue and Hitoshi Kurose :
GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance.,
Nature Communications, Vol.4, No.1532, 2013.
(DOI: 10.1038/ncomms2540,   PubMed: 23443560,   Elsevier: Scopus)
23. Kei Okatsu, Toshihiko Oka, Masahiro Iguchi, Kenji Imamura, Hidetaka Kosako, Naoki Tani, Mayumi Kimura, Etsu Go, Fumika Koyano, Manabu Funayama, Kahori Shiba-Fukushima, Shigeto Sato, Hideaki Shimizu, Yuko Fukunaga, Hisaaki Taniguchi, Masaaki Komatsu, Nobutaka Hattori, Katsuyoshi Mihara, Keiji Tanaka and Noriyuki Matsuda :
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria.,
Nature Communications, Vol.3, No.1016, 2012.
(DOI: 10.1038/ncomms2016,   PubMed: 22910362,   Elsevier: Scopus)
24. Hidetaka Kosako and Kohji Nagano :
Quantitative phosphoproteomics strategies for understanding protein kinase-mediated signal transduction pathways,
Expert Review of Proteomics, Vol.8, No.1, 81-94, 2011.
(DOI: 10.1586/epr.10.104,   PubMed: 21329429)
25. Hidetaka Kosako and Naoko Imamoto :
Phosphorylation of nucleoporins: signal transduction-mediated regulation of their interaction with nuclear transport receptors,
Nucleus, Vol.1, No.4, 309-313, 2010.
(DOI: 10.4161/nucl.1.4.11744,   PubMed: 21327077)
26. Hidetaka Kosako, Nozomi Yamaguchi, Chizuru Aranami, Masato Ushiyama, Shingo Kose, Naoko Imamoto, Hisaaki Taniguchi, Eisuke Nishida and Seisuke Hattori :
Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport,
Nature Structural & Molecular Biology, Vol.16, No.10, 1026-1035, 2009.
(DOI: 10.1038/nsmb.1656,   PubMed: 19767751)
27. Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Tohru Tezuka, Takashi Sekine, Takashi Igarashi, Ikuroh Ohsawa, Shigeo Ohta and Seisuke Hattori :
Phosphorylation of Nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-γ1,
The Journal of Biological Chemistry, Vol.284, No.13, 8951-8962, 2009.
(DOI: 10.1074/jbc.M806851200,   PubMed: 19179337)
28. Seisuke Hattori, Naoyuki Iida and Hidetaka Kosako :
Identification of protein kinase substrates by proteomic approaches.,
Expert Review of Proteomics, Vol.5, No.3, 497-505, 2008.
(DOI: 10.1586/14789450.5.3.497,   PubMed: 18532915)
29. Yutaka Harita, Hidetake Kurihara, Hidetaka Kosako, Tohru Tezuka, Takashi Sekine, Takashi Igarashi and Seisuke Hattori :
Neph1, a component of the kidney slit diaphragm, is tyrosine phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.,
The Journal of Biological Chemistry, Vol.283, No.14, 9177-9186, 2008.
(DOI: 10.1074/jbc.M707247200,   PubMed: 18258597)
30. Mei-Ying Han, Hidetaka Kosako, Toshiki Watanabe and Seisuke Hattori :
Extracellular signal-regulated kinase/mitogen-activated protein kinase regulates actin organization and cell motility by phosphorylating the actin cross-linking protein EPLIN.,
Molecular and Cellular Biology, Vol.27, No.23, 8190-8204, 2007.
(DOI: 10.1128/MCB.00661-07,   PubMed: 17875928)
31. Michimoto Kobayashi, Takuya Katagiri, Hidetaka Kosako, Naoyuki Iida and Seisuke Hattori :
Global analysis of dynamic changes in lipid raft proteins during T-cell activation.,
Electrophoresis, Vol.28, No.12, 2035-2043, 2007.
(DOI: 10.1002/elps.200600675,   PubMed: 17486660,   Elsevier: Scopus)
32. Mitsuyo Machida, Hidetaka Kosako, Kyoko Shirakabe, Michimoto Kobayashi, Masato Ushiyama, Junichi Inagawa, Joe Hirano, Tomoyo Nakano, Yasuhiko Bando, Eisuke Nishida and Seisuke Hattori :
Purification of phosphoproteins by immobilized metal affinity chromatography and its application to phosphoproteome analysis.,
The FEBS Journal, Vol.274, No.6, 1576-1587, 2007.
(DOI: 10.1111/j.1742-4658.2007.05705.x,   PubMed: 17480206)
33. Koji Ueda, Hidetaka Kosako, Yasuhisa Fukui and Seisuke Hattori :
Proteomic identification of Bcl2-associated athanogene 2 as a novel MAPK-activated protein kinase 2 substrate.,
The Journal of Biological Chemistry, Vol.279, No.40, 41815-41821, 2004.
(DOI: 10.1074/jbc.M406049200,   PubMed: 15271996)
34. Shin-ichi Yamamoto, Motoshi Nagao, Michiya Sugimori, Hidetaka Kosako, Hirofumi Nakatomi, Naoya Yamamoto, Hirohide Takebayashi, Yo-ichi Nabeshima, Toshio Kitamura, Gerry Weinmaster, Kozo Nakamura and Masato Nakafuku :
Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord.,
The Journal of Neuroscience, Vol.21, No.24, 9814-9823, 2001.
(PubMed: 11739589,   Elsevier: Scopus)
35. Rumiko Mizuguchi, Michiya Sugimori, Hirohide Takebayashi, Hidetaka Kosako, Motoshi Nagao, Shosei Yoshida, Yo-ichi Nabeshima, Kenji Shimamura and Masato Nakafuku :
Combinatorial roles of Olig2 and Neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons.,
Neuron, Vol.31, No.5, 757-771, 2001.
(DOI: 10.1016/S0896-6273(01)00413-5,   PubMed: 11567615,   Elsevier: Scopus)
36. Hidetaka Kosako, Toshimichi Yoshida, Fumio Matsumura, Toshimasa Ishizaki, Shuh Narumiya and Masaki Inagaki :
Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.,
Oncogene, Vol.19, No.52, 6059-6064, 2000.
(DOI: 10.1038/sj.onc.1203987,   PubMed: 11146558,   Elsevier: Scopus)
37. Hirohide Takebayashi, Shosei Yoshida, Michiya Sugimori, Hidetaka Kosako, Ryo Kominami, Masato Nakafuku and Yo-ichi Nabeshima :
Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3.,
Mechanisms of Development, Vol.99, No.1-2, 143-148, 2000.
(DOI: 10.1016/S0925-4773(00)00466-4,   PubMed: 11091082,   CiNii: 30005454077,   Elsevier: Scopus)
38. Hidemasa Goto, Hidetaka Kosako and Masaki Inagaki :
Regulation of intermediate filament organization during cytokinesis: possible roles of Rho-associated kinase.,
Microscopy Research and Technique, Vol.49, No.2, 173-182, 2000.
(DOI: 10.1002/(SICI)1097-0029(20000415)49:2<173::AID-JEMT10>3.0.CO;2-A,   PubMed: 10816257,   Elsevier: Scopus)
39. Hidemasa Goto, Yasuko Tomono, Kozo Ajiro, Hidetaka Kosako, Masatosi Fujita, Minoru Sakurai, Katsuya Okawa, Akihiro Iwamatsu, Tohru Okigaki, Toshitada Takahashi and Masaki Inagaki :
Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation.,
The Journal of Biological Chemistry, Vol.274, No.36, 25543-25549, 1999.
(DOI: 10.1074/jbc.274.36.25543,   PubMed: 10464286,   CiNii: 80011300961,   Elsevier: Scopus)
40. Ryota Hashimoto, Yu Nakamura, Hidetaka Kosako, Mutsuki Amano, Kozo Kaibuchi, Masaki Inagaki and Masatoshi Takeda :
Distribution of Rho-kinase in the bovine brain.,
Biochemical and Biophysical Research Communications, Vol.263, No.2, 575-579, 1999.
41. Hidetaka Kosako, Hidemasa Goto, Maki Yanagida, Kaori Matsuzawa, Masatoshi Fujita, Yasuko Tomono, Tohru Okigaki, Hideharu Odai, Kozo Kaibuchi and Masaki Inagaki :
Specific accumulation of Rho-associated kinase at the cleavage furrow during cytokinesis: cleavage furrow-specific phosphorylation of intermediate filaments.,
Oncogene, Vol.18, No.17, 2783-2788, 1999.
42. Hidemasa Goto, Hidetaka Kosako, Kazushi Tanabe, Maki Yanagida, Minoru Sakurai, Mutsuki Amano, Kozo Kaibuchi and Masaki Inagaki :
Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis.,
The Journal of Biological Chemistry, Vol.273, No.19, 11728-11736, 1998.
43. Hidetaka Kosako, Mutsuki Amano, Maki Yanagida, Kazushi Tanabe, Yoshimi Nishi, Kozo Kaibuchi and Masaki Inagaki :
Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.,
The Journal of Biological Chemistry, Vol.272, No.16, 10333-10336, 1997.
44. Kaori Matsuzawa, Hidetaka Kosako, Naoyuki Inagaki, Hideki Shibata, Hideyuki Mukai, Yoshitaka Ono, Mutsuki Amano, Kozo Kaibuchi, Yoshiharu Matsuura, Ichiro Azuma and Masaki Inagaki :
Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN.,
Biochemical and Biophysical Research Communications, Vol.234, No.3, 621-625, 1997.
45. Hidetaka Kosako, Yukiko Gotoh and Eisuke Nishida :
Multiple roles of the mitogen-activated protein kinase kinase/mitogen-activated protein kinase cascade in Xenopus laevis.,
Development Growth & Differentiation, Vol.38, 577-582, 1996.
46. Hidetaka Kosako, Yoshiko Akamatsu, Naoya Tsurushita, Lee Kyung-Kwon, Yukiko Gotoh and Eisuke Nishida :
Isolation and characterization of neutralizing single-chain antibodies against Xenopus mitogen-activated protein kinase kinase from phage display libraries.,
Biochemistry, Vol.35, No.40, 13212-13221, 1996.
47. Makoto Fukuda, Yukiko Gotoh, Hidetaka Kosako, Seisuke Hattori and Eisuke Nishida :
Analysis of the Ras p21/mitogen-activated protein kinase signaling in vitro and in Xenopus oocytes.,
The Journal of Biological Chemistry, Vol.269, No.52, 33097-33101, 1994.
48. Hidetaka Kosako, Yukiko Gotoh and Eisuke Nishida :
Mitogen-activated protein kinase kinase is required for the Mos-induced metaphase arrest.,
The Journal of Biological Chemistry, Vol.269, No.45, 28354-28358, 1994.
49. Yukiko Gotoh, Satoshi Matsuda, Katsuya Takenaka, Seisuke Hattori, Akihiro Iwamatsu, Masaharu Ishikawa, Hidetaka Kosako and Eisuke Nishida :
Characterization of recombinant Xenopus MAP kinase kinases mutated at potential phosphorylation sites.,
Oncogene, Vol.9, No.7, 1891-1898, 1994.
50. Hidetaka Kosako, Yukiko Gotoh and Eisuke Nishida :
Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.,
The EMBO Journal, Vol.13, No.9, 2131-2138, 1994.
51. Hidetaka Kosako, Yukiko Gotoh and Eisuke Nishida :
Regulation and function of the MAP kinase cascade in Xenopus oocytes.,
Journal of Cell Science, Vol.18, 115-119, 1994.
52. Hidetaka Kosako, Eisuke Nishida and Yukiko Gotoh :
cDNA cloning of MAP kinase kinase reveals kinase cascade pathways in yeasts to vertebrates.,
The EMBO Journal, Vol.12, No.2, 787-794, 1993.
53. Kazuyuki Tobe, Takashi Kadowaki, Kenta Hara, Yukiko Gotoh, Hidetaka Kosako, Satoshi Matsuda, Hiroyuki Tamemoto, Kohjiro Ueki, Yasuo Akanuma, Eisuke Nishida and Yoshio Yazaki :
Sequential activation of MAP kinase activator, MAP kinases, and S6 peptide kinase in intact rat liver following insulin injection.,
The Journal of Biological Chemistry, Vol.267, No.29, 21089-21097, 1992.
54. Hidetaka Kosako, Yukiko Gotoh, Satoshi Matsuda, Satoshi Matsuda and Eisuke Nishida :
Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.,
The EMBO Journal, Vol.11, No.8, 2903-2908, 1992.
55. Satoshi Matsuda, Hidetaka Kosako, Katsuya Takenaka, Kenji Moriyama, Hikoichi Sakai, Tetsu Akiyama, Yukiko Gotoh and Eisuke Nishida :
Xenopus MAP kinase activator: identification and function as a key intermediate in the phosphorylation cascade.,
The EMBO Journal, Vol.11, No.3, 973-982, 1992.
56. Yukiko Gotoh, Eisuke Nishida, Satoshi Matsuda, Nobuyuki Shiina, Hidetaka Kosako, Koichiro Shiokawa, Tetsu Akiyama, Kunihiro Ohta and Hikoichi Sakai :
In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase.,
Nature, Vol.349, No.6306, 251-254, 1991.
(DOI: 10.1038/349251a0,   PubMed: 1702878)

Review, Commentary:

1. Hidetaka Kosako and Kou Motani :
Phos-tagなどのリン酸化プロテオミクス技術による疾患原因キナーゼの機能解析,
電気泳動, Vol.61, No.2, 53-57, Nov. 2017.
2. 新土 優樹, Hidetaka Kosako, 佐甲 靖志 and 高橋 恒一 :
Analog-to-digital Conversion in the Cellular Signaling System,
Seibutsu Butsuri, Vol.56, No.6, 334-336, Sep. 2016.
(DOI: 10.2142/biophys.56.334,   CiNii: 130005170660)
3. Hidetaka Kosako :
タンパク質キナーゼとユビキチンリガーゼの連携によるミトコンドリアの品質管理機構とパーキンソン病,
日本応用酵素協会誌, No.50, 11-19, Mar. 2016.
4. Hidetaka Kosako :
Proteomic analyses reveal regulation of the nuclear pore complex by post-translational modifications,
Seikagaku, Vol.87, No.1, 49-55, Feb. 2015.
(PubMed: 26571555,   CiNii: 40020383555)
5. Hidetaka Kosako :
Global analysis of protein kinase substrates using phosphoproteomic techniques,
Seikagaku, Vol.83, No.12, 1122-1127, Dec. 2011.
(PubMed: 22352043,   CiNii: 10030345967)
6. Hidetaka Kosako :
リン酸化プロテオミクスで明らかとなったERKによる核膜孔複合体の機能制御,
Experimental Medicine, Vol.28, No.1, 69-73, 2010.
7. Hidetaka Kosako, 牛山 正人 and 服部 成介 :
2D DIGE技術を用いたリン酸化プロテオーム解析によるシグナル伝達経路構成因子の網羅的同定法,
Experimental Medicine, Vol.22, No.9, 1299-1304, 2004.
8. Hidetaka Kosako :
GST融合タンパク質からGSTを除去する方法,
Experimental Medicine, Vol.18, No.16, 2270-2271, 2000.
9. Hidetaka Kosako :
特異性の高いポリクローナル抗体の作製上のポイント,
Experimental Medicine, Vol.18, No.17, 2379-2380, 2000.
10. Hidetaka Kosako, 後藤 英仁 and 稲垣 昌樹 :
抗リン酸化ペプチド抗体の簡易作製法,
Experimental Medicine, Vol.16, No.6, 823-827, 1998.
11. Hidetaka Kosako and 稲垣 昌樹 :
CFキナーゼ(分裂溝キナーゼ)と細胞質分裂,
Experimental Medicine, Vol.15, No.10, 1185-1190, 1997.

Proceeding of International Conference:

1. Izumi Ohigashi, Yu Tanaka, Kenta Kondou, Sayumi Fujimori, Amy C. Palin, Hiroyuki Kondo, Hidetaka Kosako and Yousuke Takahama :
Trans-omics impact of thymoproteasome in cortical thymic epithelial cells,
Cell Reports, Vol.29, No.9, May 2019.
(DOI: 10.1016/j.celrep.2019.10.079,   PubMed: 31775054,   Elsevier: Scopus)
2. Kou Motani and Hidetaka Kosako :
BioID-Based Screening of Biotinylation Sites Globally Identifies STING Interactors,
Keystone Symposia "Proteomics and its Application to Translational and Precision Medicine, Stockholm, Sweden,, Apr. 2019.
3. Yuichi Takashi, Yuka Kinoshita, Nobuaki Ito, Shun Sawatsubashi, Hidetaka Kosako, Masahiro Abe, Munehide Matsuhisa, Toshio Matsumoto and Seiji Fukumoto :
FGF receptor 1c works as a phosphate-sensor to regulate FGF23 production,
ASBMR 2018 Annual Meeting Registration Confirmation, Sep. 2018.
4. Kou Motani, Mayumi Kajimoto and Hidetaka Kosako :
Identification of the ATG8 family member GABARAPL2 as a novel TBK1 substrate,
12th International Symposium of the Institute Network, Nov. 2017.
5. Hidetaka Kosako, Megumi Kawano, Keiji Tanaka and Noriyuki Matsuda :
Quantitative interactome and phosphoproteome analysis identifies novel signaling components of Parkinson's disease-associated kinase PINK1.,
HUPO2017, Dublin, Ireland,, Sep. 2017.
6. Hidetaka Kosako, Eri Ishikawa and Sho Yamasaki :
Dissection of protein kinase D signaling during thymocyte development using various phosphoproteomic strategies.,
HUPO 2016, Taipei, Taiwan,, Sep. 2016.
7. Hidetaka Kosako :
Identification and Functional Analysis of Protein Kinase Substrates using Various Proteomic Technologies,
Keystone Symposia "The Biological Code of Cell Signaling: A Tribute to Tony Pawson", Colorado, USA, Jan. 2015.
8. Hidetaka Kosako, Naoki Tani, Shigehiro Yoshimura, Shingo Kose, Hisaaki Taniguchi and Naoko Imamoto :
Multisite phosphorylation of FG nucleoporins by MAP kinases is involved in the regulation of nucleocytoplasmic transport,
Cold Spring Harbor Laboratory Meeting "Dynamic Organization of Nuclear Function", Cold Spring Harbor, USA, Sep. 2012.
9. Hidetaka Kosako, Naoki Tani, Shigehiro Yoshimura, Shingo Kose, Megumi Kawano, Hisaaki Taniguchi and Naoko Imamoto :
Multisite phosphorylation of nucleoporins by ERK and p38 MAP kinases is implicated in the regulation of nuclear transport,
Gordon Research Conference "Phosphorylation & G-Protein Mediated Signaling Networks", Biddeford, USA, Jun. 2012.
10. Hidetaka Kosako, Naoki Tani, Shigehiro Yoshimura, Shingo Kose, Megumi Kawano, Hisaaki Taniguchi and Naoko Imamoto :
Phosphorylation of FG-repeat nucleoporins by MAP kinases is implicated in the control of nuclear transport,
EMBO Conference "Cellular Signaling & Molecular Medicine", Dubrovnik, Croatia, May 2012.
11. Hidetaka Kosako, Naoki Tani, Shigehiro Yoshimura, Shingo Kose, Megumi Kawano, Hisaaki Taniguchi and Naoko Imamoto :
Phosphorylation of FG nucleoporins by ERK and p38 MAP kinases is involved in the regulation of nucleocytoplasmic transport,
2011 American Society for Cell Biology Annual Meeting, Denver, USA, Dec. 2011.
12. Hidetaka Kosako, Shigehiro Yoshimura, Megumi Kawano, Shingo Kose and Naoko Imamoto :
Phosphorylation of multiple FG nucleoporins by MAP kinases is involved in the regulation of nucleocytoplasmic transport,
Keystone Symposia "Omics Meets Cell Biology", Alpbach, Austria, May 2011.
13. Hidetaka Kosako :
Phosphoproteomics reveals ERK MAP kinase-mediated regulation of nuclear pore complex proteins,
BIT's 3rd World Cancer Congress, Singapore, Jun. 2010.
14. Hidetaka Kosako, Chizuru Aranami, Nozomi Yamaguchi, Hitomi Suzuki, Shingo Kose, Naoko Imamoto, Hisaaki Taniguchi, Eisuke Nishida and Seisuke Hattori :
Phosphorylation of nuclear pore complex proteins by ERK MAP kinase regulates interaction with transport receptors,
49th Annual Meeting of American Society for Cell Biology, San Diego, USA, Dec. 2009.

Proceeding of Domestic Conference:

1. Izumi Ohigashi, Hidetaka Kosako and Yousuke Takahama :
Trans-omics impact of thymoproteasome in cortical thymic epithelial cells,
第42回日本分子生物学会年会, Dec. 2019.
2. 近藤 博之, 松村 貴史, Hidetaka Kosako, 伊川 正人, Yousuke Takahama and Izumi Ohigashi :
新規プロテアソーム会合因子PITHD1は精子形成を制御する,
第42回日本分子生物学学会年会, Dec. 2019.
3. Hidetaka Kosako :
ERK/MAPキナーゼシグナルの応答特性の制御,
第69回日本電気泳動学会シンポジウム, Oct. 2019.
4. Hidetaka Kosako :
シグナル伝達研究における高分解能質量分析計の活用,
第92回日本生化学会大会, Sep. 2019.
5. Hidetaka Kosako :
先端プロテオーム解析法を用いた細胞内シグナル伝達機構の解明,
第8回生命科学阿波おどりシンポジウム, Aug. 2019.
6. Hidetaka Kosako :
Elucidation of Phospho-Signaling Mechanisms using Phos-tag and Mass Spectrometry,
日本プロテオーム学会2019年大会, Jul. 2019.
7. 佐藤 美由紀, 佐藤 健 and Hidetaka Kosako :
線虫遺伝学×プロテオミクスのコラボ:父性オルガネラオートファジー制御機構の解明を目指して,
第19回日本蛋白質科学会年会・第71回日本細胞生物学会大会 合同年次大会, Jun. 2019.
8. Yuichi Takashi, Hidetaka Kosako, Shun Sawatsubashi, Yuka Kinoshita, 伊東 伸朗, Masahiro Abe, Munehide Matsuhisa, Shigeaki Kato, Toshio Matsumoto and Seiji Fukumoto :
FGFR1はFGF23濃度調節を媒介するリン感知受容体である,
日本内分泌学会雑誌, Vol.95, No.1, 333, May 2019.
9. Kou Motani, 梶本 真弓美 and Hidetaka Kosako :
BioID法によるビオチン化部位の大規模スクリーニングで明らかとなったSTINGタンパク質の相互作用因子,
第41回日本分子生物学会, Nov. 2018.
10. 近藤 博之, 松村 貴史, Hidetaka Kosako, 伊川 正人, Yousuke Takahama and Izumi Ohigashi :
プロテアソームに会合する新規分子PITHD1の機能解析,
第41回日本分子生物学会年会, Nov. 2018.
11. 谷内 秀輔, Hidetaka Kosako, Masato Miyake, Miho Oyadomari and Seiichi Oyadomari :
HMGB1とHMGB2はPERKの新規リン酸化基質である,
第13回小胞体ストレス研究会, Nov. 2018.
12. 北風 圭介, 谷内 秀輔, 河野 恵理, 濱田 良真, Masato Miyake, Miho Oyadomari, 小島 宏達, Hidetaka Kosako, 栗原 ともこ, 吉田 優, 細谷 孝充 and Seiichi Oyadomari :
細胞ベースのハイスループットスクリーニングによる新規化学シャペロンの同定,
第13回小胞体ストレス研究会, Nov. 2018.
13. Hidetaka Kosako :
シグナル伝達研究における蛍光ウェスタンの活用,
第91回日本生化学会, Sep. 2018.
14. Hidetaka Kosako :
先端プロテオミクス技術によるSTING/TBK1シグナル経路の解析,
第2回質量分析インフォマティクス・ハッカソン・シンポジウム, Jul. 2018.
15. Hidetaka Kosako :
様々なリン酸化プロテオミクス技術を用いたタンパク質キナーゼの標的基質の大規模同定と機能解析,
日本質量分析学会・日本プロテオーム学会2018年合同大会, May 2018.
16. Hidetaka Kosako :
疾患に関与する細胞内情報伝達機構を解明するためのリン酸化プロテオミクス技術,
日本質量分析学会・日本プロテオーム学会2018年合同大会, May 2018.
17. Hidetaka Kosako :
質量分析装置を用いた細胞内情報伝達機構の解析,
株式会社 東レリサーチセンター 特別講座【今から学んでも遅くない プロテオミクスと質量分析の基礎】, Jan. 2018.
18. Kou Motani, 梶本 真弓美 and Hidetaka Kosako :
TBK1による ATG8ファミリー分子 GABARAPL2のリン酸化の機能解析,
2017年度 生命科学系学会合同年次大会, Dec. 2017.
19. Hidetaka Kosako :
Phos-tag などのリン酸化プロテオミクス技術による疾患原因キナーゼの機能解析,
第68回日本電気泳動学会総会, Nov. 2017.
20. Hidetaka Kosako :
リン酸化プロテオミクスによる疾患原因キナーゼの機能解析,
第286回 発生研セミナー, Nov. 2016.
21. Hidetaka Kosako :
リン酸化プロテオミクス技術による疾患関連キナーゼの機能解析,
神戸大学医学研究科 シグナル伝達医学講演会, Aug. 2016.
22. Kou Motani, Tatsuya Takemoto, 梶本 真弓美 and Hidetaka Kosako :
細胞内自己DNAによるcGAMP/STING経路依存的・非依存的なサイトカイン誘導,
BMB2015, Dec. 2015.
23. Hidetaka Kosako :
Phos-tagなどのリン酸化プロテオミクス技術の結集によるキナーゼ基質の同定と機能解析,
BMB2015, Dec. 2015.
24. Hidetaka Kosako :
先端プロテオミクス技術によるタンパク質キナーゼ基質の同定と機能解析,
第15回日本蛋白質科学会年会, Jun. 2015.
25. Hidetaka Kosako :
リン酸化プロテオミクスを用いた疾患原因キナーゼの作用機構の解明,
第6回 脳科学クラスター・ミニリトリート, Jan. 2015.
26. Hidetaka Kosako :
リン酸化プロテオミクスによる核-細胞質間分子輸送およびPINK1/Parkin経路の解析,
第244回 発生研セミナー, Jan. 2015.
27. Hidetaka Kosako :
リン酸化プロテオミクスを用いたキナーゼ基質の機能解析,
第681回 生医研セミナー, Sep. 2014.
28. Hidetaka Kosako :
リン酸化プロテオミクスを用いた細胞内情報伝達の解明 : 統合的医科学研究に向けて,
第57回プロテオーム医療創薬研究会, Aug. 2014.
29. Hidetaka Kosako :
リン酸化プロテオミクスによるキナーゼ基質の同定と機能解析,
日本プロテオーム学会2014年会, Jul. 2014.
30. Hidetaka Kosako :
MAPキナーゼによるFGヌクレオポリンの多重リン酸化は核─細胞質間輸送を制御する,
第36回日本分子生物学会年会, Dec. 2013.
31. Hidetaka Kosako :
リン酸化プロテオミクスを用いたキナーゼターゲットの同定と機能解析,
第2回JHUPOサテライトシンポジウム, Jun. 2013.
32. Hidetaka Kosako :
蛍光標識二次元ディファレンスゲル電気泳動2D-DIGEから得られた知見と展望,
第63回日本電気泳動学会総会, Aug. 2012.
33. Hidetaka Kosako :
Phosphorylation of FG nucleoporins by MAP kinases is involved in the regulation of nuclear transport,
第34回日本分子生物学会年会, Dec. 2011.
34. Hidetaka Kosako :
プロテオミクスで明らかになったMAPキナーゼによる核膜孔タンパク質群のリン酸化制御,
平成23年度生化学会関東支部例会, Jun. 2011.
35. Hidetaka Kosako :
新たなリン酸化プロテオミクスによる細胞内キナーゼ基質の大規模同定とその機能制御機構の解明,
臨床研セミナー, Nov. 2010.
36. Hidetaka Kosako :
siRNAを用いたリン酸化シグナル伝達研究,
サーモサイエンティフィック ライフサイエンスセミナー, Jul. 2010.
37. Hidetaka Kosako :
リン酸化プロテオミクスで明らかとなったERK MAPキナーゼによる核膜孔複合体の機能制御,
理研セミナー, Mar. 2010.
38. Hidetaka Kosako :
リン酸化プロテオミクスで明らかとなった MAPキナーゼによる核膜孔複合体の機能制御,
九州大学薬学研 究院招待セミナー, Feb. 2010.
39. Hidetaka Kosako :
リン酸化プロテオミクスで明らかとなった ERK/MAPキナーゼによる核膜孔複合体の機能制御,
京都大学大 学院医学研究科学術講演会, Jan. 2010.
40. Hidetaka Kosako :
リン酸化プロテオミクスによって明ら かとなったERK/MAPキナーゼによる核膜孔複合体の機能制御,
熊本大学大学院自然科学研究科プロジェクトゼミナール, Dec. 2009.
41. Hidetaka Kosako :
リン酸化プロテオミクスで明らかとなったERK/MAPキナーゼによる核膜孔複合体の制御,
富山大学大学院医学薬学研究部特別セミナー, Nov. 2009.
42. Hidetaka Kosako, 荒波 千鶴, 山口 希実, Hitomi Suzuki, 小瀬 真吾, 今本 尚子, Hisaaki Taniguchi, 西田 栄介 and 服部 成介 :
リン酸化プロテオミクスによって明らかとなったERK/MAPキナーゼによる核膜孔複合体の機能制御,
第82回日本生化学会大会, Oct. 2009.
43. Hidetaka Kosako :
ERK/MAPキナーゼによる核膜孔複合体のリン酸化制御,
大阪大学蛋白質研究所セミナー, Jul. 2008.
44. Hidetaka Kosako :
新たなリン酸化プロテオミクスによるMAPキナーゼ基質の網羅的同定と機能解析,
基生研研究会, Apr. 2008.
45. Hidetaka Kosako, 韓 美英, 山口 希実, 牛山 正人, 西田 栄介 and 服部 成介 :
新たなリン酸化プロテオミクスによる細胞内キナーゼ基質の網羅的同定:ERK/MAPキナーゼによるアクチン架橋タンパク質EPLINのリン酸化を介した細胞運動制御,
BMB2007, Oct. 2007.
46. Hidetaka Kosako, 山口 希実, 牛山 正人, 田中 政道, 平野 穣, 西田 栄介 and 服部 成介 :
2D-DIGE技術を用いた新たなリン酸化プロテオミクスによるERK MAPキナーゼ経路の標的因子の網羅的解析,
第28回日本分子生物学会年会, Dec. 2005.
47. Hidetaka Kosako :
2D DIGE技術を利用した新たなリン酸化プロテオミクスによるMAPキナーゼ経路の標的因子の網羅的解析,
名古屋大学生命理学専攻セミナー, Jul. 2005.

Et cetera, Workshop:

1. Hidetaka Kosako :
改良型BioID法を用いた自然免疫分子STINGのインタラクトーム解析,
新学術領域研究「数理シグナル」第3回若手ワークショップ, Sep. 2019.
2. Hidetaka Kosako :
先端プロテオミクス技術による細胞内シグナル伝達機構の解明,
内分泌・代謝学共同利用・共同研究拠点セミナー, Aug. 2019.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 自然免疫分子STINGを介したシグナル伝達経路の重層的プロテオーム解析 (Project/Area Number: 19H04966 )
  • Understanding of innate immune system-mediated inflammatory response regulated by bioactive lipids (Project/Area Number: 18KK0229 )
  • パーキンソン病原因遺伝子産物PINK1が形成するシグナル系の最先端プロテオミクス (Project/Area Number: 17K08635 )
  • Identification and functional analysis of substrates of disease-associated protein kinases using multiple phosphoproteomic technologies (Project/Area Number: 26440101 )
  • Elucidation of molecular mechanisms of the selection and maturation of thymocytes (Project/Area Number: 26293108 )
  • プロテオミクスを用いたFGヌクレオポリンのリン酸化による核膜孔制御の解明 (Project/Area Number: 24113717 )
  • Proteomics and immunohistochemical analyses of phosphorylation signaling in the tumor microenvironments for breast cancer progression (Project/Area Number: 24390087 )
  • Analysis of regulatory mechanisms of newly identified ERK substrates (Project/Area Number: 23570231 )
  • シグナル伝達キナーゼによるリン酸化を介したFGヌクレオポリンの機能制御機構の解明 (Project/Area Number: 22113514 )
  • Global analysis of post-translational modifications in super-molecular protein complexes by targeted proteomics (Project/Area Number: 22370042 )
  • Global identification and functional analysis of protein kinase substrates by a phosphoproteomic approach (Project/Area Number: 20570177 )
  • イレッサ感受性診断プロテインチップの創製 (Project/Area Number: 19659080 )
  • Proteomic analysis of EGF receptor-mediated signaling (Project/Area Number: 19370041 )
  • 新たなリン酸化プロテオミクスによるMAPキナーゼ経路の標的因子の網羅的解析 (Project/Area Number: 18770166 )
  • リン酸化プロテオーム解析による腫瘍特異的転写制御機構の解明 (Project/Area Number: 18013013 )
  • リン酸化プロテオーム解析による腫瘍特異的転写制御機構の解明 (Project/Area Number: 17014022 )
  • リン酸化プロテオーム解析によるERK及びROCKの基質の網羅的同定と機能解析 (Project/Area Number: 16770141 )
  • リン酸化プロテオームによるインスリン/Akt経路の標的因子の網羅的解析法の開発 (Project/Area Number: 16012211 )
  • Molecular control mechanisms of multipotential neural stem cells (Project/Area Number: 13480254 )
  • Rho/Rho-キナーゼ経路による中間径フィラメント構築の制御機構の解明 (Project/Area Number: 11780526 )
  • 抗リン酸化抗体の利用による、細胞質分裂期に分裂溝近傍で活性化するキナーゼの同定 (Project/Area Number: 09780589 )
  • Search by Researcher Number (10291171)