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Tokushima UniversityGraduate School of Biomedical Sciences保健学域Health ScienceBiomedical Laboratory SciencesDepartment of Cells and Immunity Analytics
Tokushima UniversityGraduate School of Health SciencesHealth SciencesMedical Laboratory Sciences
Tokushima UniversityFaculty of MedicineSchool of Health SciencesMajor in Laboratory ScienceFunctional Laboratory Science
Tokushima UniversityResearch ClustersResearch Clusters2202003 1q増幅がもたらす腫瘍の進展・難治性病態の解明とその克服のための新規治療薬の創出
Tokushima UniversityResearch ClustersResearch Clusters (Registered)2203006 宿主の炎症型マクロファージを標的とした抗炎症療法の開発
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Research

Field of Study

Health Studies
Nephrology

Subject of Study

Book / Paper

Book:

1. Tatsuya Tominaga, Hideharu Abe, Akira Mima, Kojiro Nagai, Matsubara Takeshi and Toshio Doi :
Role of Smad 1 Signaling in Pathogenesis of Diabetic Nephropathy,
Nova Science Publishers, Sep. 2012.
2. Tatsuya Tominaga and Toshio Doi :
糖尿病性腎症のバイオマーカー開発と臨床への展望,
Aug. 2011.
3. Tatsuya Tominaga and Toshio Doi :
糖尿病関連遺伝子改変マウス,
Aug. 2010.

Academic Paper (Judged Full Paper):

1. Kenji Nishimura, Taichi Murakami, Toshihiro Sakurai, Masashi Miyoshi, Kiyoe Kurahashi, Seiji Kishi, Masanori Tamaki, Tatsuya Tominaga, Sumiko Yoshida, Kojiro Nagai, Hideharu Abe, Shu-Ping Hui, Kazuhiko Kotani and Toshio Doi :
Circulating Apolipoprotein L1 is associated with insulin resistance-induced abnormal lipid metabolism.,
Scientific Reports, Vol.9, No.1, 14869, 2019.
(Tokushima University Institutional Repository: 114663,   DOI: 10.1038/s41598-019-51367-7,   PubMed: 31619724)
2. Akiko Sakurai, Hiroyuki Ono, Arisa Ochi, Motokazu Matsuura, Sakiya Yoshimoto, Seiji Kishi, Taichi Murakami, Tatsuya Tominaga, Kojiro Nagai, Hideharu Abe and Toshio Doi :
Involvement of Elf3 on Smad3 activation-dependent injuries in podocytes and excretion of urinary exosome in diabetic nephropathy.,
PLoS ONE, Vol.14, No.5, 2019.
(Tokushima University Institutional Repository: 114344,   DOI: 10.1371/journal.pone.0216788,   PubMed: 31150422)
3. 藤田 結衣, Tatsuya Tominaga, 寒川 裕未, Kojiro Nagai, Hideharu Abe and Toshio Doi :
BMP4 regulates both podocyte injury and mesangial expansion in the diabetic nephropathy,
Shikoku Acta Medica, Vol.75, No.1-2, 55-62, 2019.
(Tokushima University Institutional Repository: 113757,   CiNii: 1050865122806331136)
4. Masanori Tamaki, Tatsuya Tominaga, Yui Fujita, Yasuhiko Koezuka, Go Ichien, Taichi Murakami, Seiji Kishi, Keiichi Yamamoto, Hideharu Abe, Kojiro Nagai and Toshio Doi :
All-trans retinoic acid suppresses bone morphogenetic protein 4 in mouse diabetic nephropathy through a unique retinoic acid response element.,
American Journal of Physiology, Endocrinology and Metabolism, Vol.316, No.3, E418-E431, 2019.
(DOI: 10.1152/ajpendo.00218.2018,   PubMed: 30601699)
5. Tatsuya Tominaga, Isha Sharma, Yui Fujita, Toshio Doi, K Aryana Wallner and S Yashpal Kanwar :
Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress.,
American Journal of Physiology, Renal Physiology, Vol.316, No.2, F301-F315, 2018.
(DOI: 10.1152/ajprenal.00534.2018,   PubMed: 30539651,   Elsevier: Scopus)
6. Yui Fujita, Tatsuya Tominaga, Hideharu Abe, Yumi Kangawa, Naoshi Fukushima, Otoya Ueda, Kou-Ichi Jishage, Seiji Kishi, Taichi Murakami, Yumiko Saga, S Yashpal Kanwar, Kojiro Nagai and Toshio Doi :
An adjustment in BMP4 function represents a treatment for diabetic nephropathy and podocyte injury.,
Scientific Reports, Vol.8, No.1, 2018.
(Tokushima University Institutional Repository: 112896,   DOI: 10.1038/s41598-018-31464-9,   PubMed: 30158674)
7. Hiroyuki Ono, Hideharu Abe, Akiko Sakurai, Arisa Ochi, Tatsuya Tominaga, Masanori Tamaki, Seiji Kishi, Taichi Murakami, Kojiro Nagai, Masayuki Kohashi and Toshio Doi :
Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy.,
Scientific Reports, Vol.8, No.1, 2018.
(Tokushima University Institutional Repository: 112878,   DOI: 10.1038/s41598-018-28439-1,   PubMed: 30002389)
8. Fumi Kishi, Kojiro Nagai, Norimichi Takamatsu, Tatsuya Tominaga, Masanori Tamaki, E. Shibata, Taichi Murakami, Seiji Kishi, Hideharu Abe, Y Koezuka, N Minagawa, G Ichien and Toshio Doi :
Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study.,
PLoS ONE, Vol.13, No.4, e0195523, 2018.
(Tokushima University Institutional Repository: 112361,   DOI: 10.1371/journal.pone.0195523,   PubMed: 29624611)
9. Toshio Doi, Hideharu Abe, Seiji Kishi, Taichi Murakami, Kojiro Nagai and Tatsuya Tominaga :
Urinary IgG4 and Smad1 are Specific Biomarkers for Renal Structural and Functional Changes in Early Stages of Diabetic Nephropathy.,
Diabetes, Vol.67, No.5, 986-993, 2018.
(DOI: 10.2337/db17-1043,   PubMed: 29490904)
10. Hideharu Abe and Tatsuya Tominaga :
New insights into the molecular pathology and the development of predictive biomarkers in diabetic mephropathy.,
Trends in Cell & Molecular Biology, Vol.13, No.4, 19-26, 2018.
11. Kojiro Nagai, Tatsuya Tominaga, Sayo Ueda, Eriko Shibata, Masanori Tamaki, Motokazu Matsuura, Seiji Kishi, Taichi Murakami, Tatsumi Moriya, Hideharu Abe and Toshio Doi :
Mesangial Cell Mammalian Target of Rapamycin Complex 1 Activation Results in Mesangial Expansion.,
Journal of the American Society of Nephrology, Vol.28, No.10, 2879-2885, 2017.
(DOI: 10.1681/ASN.2016111196,   PubMed: 28701517,   Elsevier: Scopus)
12. Motokazu Matsuura, Hideharu Abe, Tatsuya Tominaga, Akiko Sakurai, Taichi Murakami, Seiji Kishi, Yoshimi Bando, Jun Minakuchi, Kojiro Nagai and Toshio Doi :
A Novel Method of DAPI Staining for Differential Diagnosis of Renal Amyloidosis.,
The Journal of Medical Investigation : JMI, Vol.64, No.3.4, 217-221, 2017.
(Tokushima University Institutional Repository: 111119,   DOI: 10.2152/jmi.64.217,   PubMed: 28954985)
13. Tatsuya Tominaga, K Rajesh Dutta, Darukeshwara Joladarashi, Toshio Doi, K Janardan Reddy and S Yashpal Kanwar :
Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.,
The Journal of Biological Chemistry, Vol.291, No.3, 1348-1367, 2015.
(Tokushima University Institutional Repository: 119320,   DOI: 10.1074/jbc.M115.698191,   PubMed: 26578517,   Elsevier: Scopus)
14. Takahiro Hirano, Taichi Murakami, Hiroyuki Ono, Akiko Sakurai, Tatsuya Tominaga, Toshikazu Takahashi, Kojiro Nagai, Toshio Doi and Hideharu Abe :
A Novel Interaction between FLICE-Associated Huge Protein (FLASH) and E2A Regulates Cell Proliferation and Cellular Senescence via Tumor Necrosis Factor (TNF)-Alpha-p21WAF1/CIP1 Axis.,
PLoS ONE, Vol.10, No.7, e0133205, 2015.
(Tokushima University Institutional Repository: 114923,   DOI: 10.1371/journal.pone.0133205,   PubMed: 26208142,   Elsevier: Scopus)
15. Takeshi Matsubara, Makoto Araki, Hideharu Abe, Otoya Ueda, Kou-Ichi Jishage, Akira Mima, Chisato Goto, Tatsuya Tominaga, Masahiko Kinosaki, Seiji Kishi, Kojiro Nagai, Noriyuki Iehara, Naoshi Fukushima, Toru Kita, Hidenori Arai and Toshio Doi :
Bone Morphogenetic Protein 4 and Smad1 Mediate Extracellular Matrix Production in the Development of Diabetic Nephropathy.,
Diabetes, Vol.64, No.8, 2978-2990, 2015.
(DOI: 10.2337/db14-0893,   PubMed: 25995358,   Elsevier: Scopus)
16. Kazuhiro Yoshikawa, Hideharu Abe, Tatsuya Tominaga, Masayuki Nakamura, Seiji Kishi, Motokazu Matsuura, Kojiro Nagai, Kenji Tsuchida, Jun Minakuchi and Toshio Doi :
Polymorphism in the human matrix Gla protein gene is associated with the progression of vascular calcification in maintenance hemodialysis patients,
Clinical and Experimental Nephrology, Vol.17, No.6, 882-889, 2013.
(Tokushima University Institutional Repository: 105885,   DOI: 10.1007/s10157-013-0785-9,   PubMed: 23504408,   Elsevier: Scopus)
17. Kojiro Nagai, Masashi Miyoshi, Takei Kake, Naoshi Fukushima, Motokazu Matsuura, Eriko Shibata, Satoshi Yamada, Kazuhiro Yoshikawa, Hiro-omi Kanayama, Tomoya Fukawa, Kunihisa Yamaguchi, Hirofumi Izaki, Akira Mima, Naoko Abe, Toshikazu Araoka, Taichi Murakami, Fumi Kishi, Seiji Kishi, Tatsuya Tominaga, Tatsumi Moriya, Hideharu Abe and Toshio Doi :
Dual Involvement of Growth Arrest-specific Gene 6 in the Early Phase of Human IgA Nephropathy,
PLoS ONE, Vol.8, No.6, e66759, 2013.
(DOI: 10.1371/journal.pone.0066759,   PubMed: 23826128,   Elsevier: Scopus)
18. Hideharu Abe, Tatsuya Tominaga, Takeshi Matsubara, Naoko Abe, Seiji Kishi, Kojiro Nagai, Taichi Murakami, Toshikazu Araoka and Toshio Doi :
Scleraxis modulates bone morphogenetic protein 4 (BMP4)-Smad1 protein-smooth muscle -actin (SMA) signal transduction in diabetic nephropathy.,
The Journal of Biological Chemistry, Vol.287, No.24, 20430-20442, 2012.
(DOI: 10.1074/jbc.M111.275610,   PubMed: 22474292)
19. Seiji Kishi, Hideharu Abe, Haruhiko Akiyama, Tatsuya Tominaga, Taichi Murakami, Akira Mima, Kojiro Nagai, Fumi Kishi, Motokazu Matsuura, Takeshi Matsubara, Noriyuki Iehara, Otoya Ueda, Naoshi Fukushima, Kou-Ichi Jishage and Toshio Doi :
SOX9 protein induces a chondrogenic phenotype of mesangial cells and contributes to advanced diabetic nephropathy.,
The Journal of Biological Chemistry, Vol.286, No.37, 32162-32169, 2011.
(DOI: 10.1074/jbc.M111.244541,   PubMed: 21795715)
20. Tatsuya Tominaga, Hideharu Abe, Otoya Ueda, Chisato Goto, Kunihiko Nakahara, Taichi Murakami, Takeshi Matsubara, Akira Mima, Kojiro Nagai, Toshikazu Araoka, Seiji Kishi, Naoshi Fukushima, Kou-ichi Jishage and Toshio Doi :
Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy.,
The Journal of Biological Chemistry, Vol.286, No.22, 20109-20116, 2011.
(DOI: 10.1074/jbc.M110.179382,   PubMed: 21471216)
21. Akira Mima, Hideharu Abe, Kojiro Nagai, Hidenori Arai, Takeshi Matsubara, Makoto Araki, Kazuo Torikoshi, Tatsuya Tominaga, Noriyuki Iehara, Atsushi Fukatsu, Toru Kita and Toshio Doi :
Activation of Src mediates PDGF-induced Smad1 phosphorylation and contributes to the progression of glomerulosclerosis in glomerulonephritis.,
PLoS ONE, Vol.6, No.3, e17929, 2011.
(DOI: 10.1371/journal.pone.0017929,   PubMed: 21445358)
22. Taichi Murakami, Hideharu Abe, Kojiro Nagai, Tatsuya Tominaga, Norimichi Takamatsu, Toshikazu Araoka, Seiji Kishi, Toshikazu Takahashi, Akira Mima, Yoshimi Takai, Jeffrey B. Kopp and Toshio Doi :
Trophoblast glycoprotein: possible candidate mediating podocyte injuries in glomerulonephritis.,
American Journal of Nephrology, Vol.32, No.6, 505-521, 2010.
(DOI: 10.1159/000321366,   PubMed: 20980737,   Elsevier: Scopus)
23. Norimichi Takamatsu, Hideharu Abe, Tatsuya Tominaga, Kunihiko Nakahara, Yumi Ito, Yoko Okumoto, Jiyoong Kim, Masafumi Kitakaze and Toshio Doi :
Risk factors for chronic kidney disease in Japan: a community-based study.,
BMC Nephrology, Vol.10, 34, 2009.
(DOI: 10.1186/1471-2369-10-34,   PubMed: 19860890)
24. Toshio Doi, Akira Mima, Takeshi Matsubara, Tatsuya Tominaga, Hidenori Arai and Hideharu Abe :
The current clinical problems for early phase of diabetic nephropathy and approach for pathogenesis of diabetic nephropathy.,
Diabetes Research and Clinical Practice, Vol.82, No.Suppl 1, S21-4, 2008.
(DOI: 10.1016/j.diabres.2008.09.013,   PubMed: 18842318)
25. Akira Mima, Hidenori Arai, Takeshi Matsubara, Hideharu Abe, Kojiro Nagai, Yukinori Tamura, Kazuo Torikoshi, Makoto Araki, Hiroshi Kanamori, Toshikazu Takahashi, Tatsuya Tominaga, Motokazu Matsuura, Noriyuki Iehara, Atsushi Fukatsu, Toru Kita and Toshio Doi :
Urinary Smad1 is a novel marker to predict later onset of mesangial matrix expansion in diabetic nephropathy.,
Diabetes, Vol.57, No.6, 1712-1722, 2008.
(DOI: 10.2337/db07-1726,   PubMed: 18285555)

Review, Commentary:

1. 荒岡 利和, Hideharu Abe, Kojiro Nagai, Akira Mima, Tatsuya Tominaga, 松浦 元一, 村上 太一, 岸 誠司, 繁田 令子, 岸 史, 吉川 和寛 and 土井 俊夫 :
2型糖尿病原因遺伝子TCF7L2を介した糖尿病性腎症感受性遺伝子ALK1の分子調節機構の解析,
Diabetes Frontier, Vol.21, No.5, 614, Oct. 2010.

Proceeding of International Conference:

1. Masanori Tamaki, Tatsuya Tominaga, Yui Fujita, Taichi Murakami, Seiji Kishi, Hideharu Abe, Kojiro Nagai and Toshio Doi :
A Novel All-Trans Retinoic Acid Therapy Directly Suppresses Bone Morphogenetic Protein 4 in Mouse Diabetic Nephropathy,
KIDNEY WEEK 2019 American Society of Nephrology, Nov. 2019.
2. Masanori Tamaki, Tatsuya Tominaga, Yui Fujita, Seiji Kishi, Taichi Murakami, Kojiro Nagai, Hideharu Abe and Toshio Doi :
Mesangial Matrix Expansion Attenuated by All-Trans Retinoic Acid Through Direct Suppression of Bone Morphogenetic Protein 4 in Mouse Diabetic Nephropathy,
KIDNEY WEEK 2018 American Society of Nephrology, Oct. 2018.
3. Yui Fujita, Tatsuya Tominaga, Masanori Tamaki, Taichi Murakami, Seiji Kishi, Kojiro Nagai, Hideharu Abe and Toshio Doi :
Palovarotene, Selective Retinoic Receptor- Agonist, Inhibited Both BMP4 and TGF- Signaling Pathways in Diabetic Nephropathy,
KIDNEY WEEK 2017 American Society of Nephrology, Nov. 2017.
4. Masanori Tamaki, Tatsuya Tominaga, Yui Fujita, Seiji Kishi, Taichi Murakami, Kojiro Nagai, Hideharu Abe and Toshio Doi :
Glomerulosclerosis Attenuated by Retinoic Acid through Bone Morphogenetic Protein 4 Suppression in Mice with Streptozotocin-Induced Diabetes,
KIDNEY WEEK 2017 American Society of Nephrology, Nov. 2017.
5. Kojiro Nagai, Tatsuya Tominaga, Taichi Murakami, Eriko Shibata, Seiji Kishi, Motokazu Matsuura, Hideharu Abe and Toshio Doi :
In vivo evidence of mTORC1-S6 kinase pathway involvement in the development of glomerulosclerosis in human IgA nephropathy,
KIDNEY WEEK 2016 American Society of Nephrology, Nov. 2016.
6. Yui Fujita, Tatsuya Tominaga, Taichi Murakami, Seiji Kishi, Kojiro Nagai, Hideharu Abe and Toshio Doi :
The Role of BMP4 Signal Pathway on the Podocyte Injury in Diabetic Early Stage,
ASN Kidney week 2016, Nov. 2016.
7. Tatsuya Tominaga, Toshio Doi and Kanwar S Yashpal :
Myo-inositol oxygenase (MIOX) contributes to renal tubular injury through ER stress and a hyaluronic acid (HA) production,
American Society of Nephrology Kidney Week 2015, Nov. 2015.
8. Tupe Santosh Rashmi, Tatsuya Tominaga and Kanwar S. Yashpal :
Advanced Glycation End Products Induces Myo-Inositol Oxygenase via Activation of PI3K Pathwayin Proximal Tubular Epithelial Cells,
American Society of Nephrology Kidney Week 2014, Nov. 2014.
9. Zhan Ming, Tatsuya Tominaga, Sun Lin and Kanwar S Yashpal :
Myo-Inositol Oxygenase (MIOX) Modulates Mitochondrial Dynamics and Autophagy in Diabetic Tubulopathy,
American Society of Nephrology Kidney Week 2013, Nov. 2013.
10. Tatsuya Tominaga, Zhan Ming and Kanwar S Yashpal :
Relevance of Myo-Inositol Oxigenase (MIOX) in Renal Tubular Injury in Obesity/Metabolic Syndrome,
American Society of Nephrology Kidney Week 2013, Nov. 2013.
11. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Akira Mima, Seiji Kishi, K Jishage, N Fukushima and Toshio Doi :
Role of BMP4 for regulating podocyte injury in the diabetic nephropathy.,
American Society for Cell biology, San Francisco, Dec. 2012.
12. Masashi Miyoshi, Kojiro Nagai, Takei Kake, Naoshi Fukushima, Motokazu Matsuura, Eriko Shibata, Satoshi Yamada, Kazuhiro Yoshikawa, Akira Mima, Fumi Kishi, Seiji Kishi, Tatsuya Tominaga, Hideharu Abe and Toshio Doi :
Expression of Gas6 and Axl in Human IgA Nephropathy. ~A Possible Involvement of Gas6 in Podocyte Injury~,
American Society of Nephrology Kidney Week 2012, San Diego, Nov. 2012.
13. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Seiji Kishi, Akira Mima and Toshio Doi :
BMP4 regulates podocyte injury in the diabetic nephropathy,
Diabetes, Philadelphia, May 2012.
14. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Seiji Kishi and Toshio Doi :
BMP4 regulates podocyte injury in the diabetic nephropathy,
The 1st Asia-Pacific Vascular Biology Meeting, Dec. 2011.
15. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Seiji Kishi, Taichi Murakami and Toshio Doi :
BMP4 regulates podocyte injury in the diabetic nephropathy,
Journal of the American Society of Nephrology, Nov. 2011.
16. Akira Mima, H Arai, T Matsubara, Hideharu Abe, H Kanamori, E Sumi, Tatsuya Tominaga, T Takahashi, Motokazu Matsuura, N Iehara, A Fukatsu, T Kita and Toshio Doi :
Angiotensin II type I receptor blocker decreases urinary Smad1, a marker for mesangial matrix expansion in diabetic nephropathy,
2007 World Congress of Nephrology, リオデジャネイロ, Apr. 2007.

Proceeding of Domestic Conference:

1. YONEMOTO Haruka, Tatsuya Tominaga, Akiko Sakurai and Keiko Kataoka :
細菌由来細胞外小胞(エクソソーム)放出量の検討,
第47回 徳島県医学検査学会, Dec. 2023.
2. YOSHINO Takumi, MATSUMOTO Kotomi, WAKABAYASHI Ryuya, Akiko Sakurai and Tatsuya Tominaga :
高脂肪食負荷が腎臓に及ぼすERストレスへの影響について②,
第47回 徳島県医学検査学会, Dec. 2023.
3. MATSUMOTO Kotomi, YOSHINO Takumi, WAKABAYASHI Ryuya, Akiko Sakurai and Tatsuya Tominaga :
高脂肪食負荷が腎臓に及ぼすERストレスへの影響について①,
第47回徳島県医学検査学会, Dec. 2023.
4. Masanori Tamaki, 越智 ありさ, Tatsuya Tominaga, Eriko Shibata and Shu Wakino :
Parkinは糖尿病やBMP4が惹起するミトコンドリアターンオーバー障害の治療標的である,
Japanese Journal of Nephrology, Vol.65, No.3, 251, May 2023.
5. Masanobu Miyashiro, RYUYA Wakabayashi, Akiko Sakurai and Tatsuya Tominaga :
腎脂質代謝異常とERストレスの作用機序について 「ApoE欠損動脈硬化症モデルマウスでの検討」,
第46回徳島県医学検査学会, Dec. 2022.
6. 越智 ありさ, Akiko Sakurai, 太田 浩二, 飛永 恭兵, RYUYA Wakabayashi, Shu Wakino, Koichi Ute and Tatsuya Tominaga :
A new purification method for exosome, using highly water-absorbing polymer.,
第45回日本分子生物学会年会, Dec. 2022.
7. RYUYA Wakabayashi, Akiko Sakurai, 越智 ありさ and Tatsuya Tominaga :
腎硬化症における小胞体ストレス分子メカニズムの解析,
第45回日本分子生物学会年会, Dec. 2022.
8. RYUYA Wakabayashi, Akiko Sakurai, 越智 ありさ and Tatsuya Tominaga :
小胞体ストレス誘導下における腎線維化とBMP4/CHOPの機能解析,
第95回日本生化学会大会, Nov. 2022.
9. TAKAHASHI Sakura, Rena Takizawa, Daisuke Tsuji, Kouji Itou, Tatsuya Tominaga, Yoshiki Kashiwada and Naonobu Tanaka :
神田茶「茶汁」に含まれるカテキン代謝物の構造と生物活性,
第9回食品薬学シンポジウム, 118-120, Oct. 2022.
10. Ryuya Wakabayashi, Kanako Tamura, Akiko Sakurai and Tatsuya Tominaga :
腎線維化病変発症機序の解析,
第45回徳島県医学検査学会, Dec. 2021.
11. Kanako Tamura, Ryuya Wakabayashi, Akiko Sakurai and Tatsuya Tominaga :
血管内皮特異的BMP4発現マウスへの高脂肪食負荷による影響について,
第45回徳島県医学検査学会, Dec. 2021.
12. Masanori Tamaki, Hiroyuki Ono, Kenji Nishimura, Eriko Shibata, Sayo Ueda, 越智 ありさ, Tatsuya Tominaga, Kojiro Nagai and Hideharu Abe :
骨形成因子4(BMP4)はメサンギウム細胞のミトコンドリア障害を惹起する,
Japanese Journal of Nephrology, Vol.62, No.4, 282, Jul. 2020.
13. Maki Takemura, Tatsuya Tominaga, Aya Mitsuhashi, Kojiro Nagai and Hideharu Abe :
糖尿病における高タンパク食が腎臓に与える影響について②,
徳島県臨床検査技師会誌 第43回徳島県医学検査学会抄録集, Dec. 2019.
14. Aya Mitsuhashi, Tatsuya Tominaga, Maki Takemura, Kojiro Nagai and Hideharu Abe :
糖尿病における高タンパク食が腎臓に与える影響について①,
徳島県臨床検査技師会誌 第43回徳島県医学検査学会抄録集, Dec. 2019.
15. Hiroyuki Ono, Hideharu Abe, Masanori Tamaki, Tatsuya Tominaga, Fumi Kishi, Seiji Kishi, Taichi Murakami, Kojiro Nagai and Toshio Doi :
Smad1とSmad3の新規相互リン酸化制御機構による糖尿病性腎症の病態解析,
第62回日本腎臓学会学術総会, Jun. 2019.
16. Fumi Kishi, Kojiro Nagai, Tatsuya Tominaga, Masanori Tamaki, 柴田 恵理子, Taichi Murakami, Seiji Kishi, 肥塚 靖彦, 皆川 直人, 一圓 剛, Norimichi Takamatsu and Toshio Doi :
尿中IV型コラーゲンは非糖尿病一般住民における糸球体濾過率低下に関与する,
第61回日本腎臓学会学術総会, Jun. 2018.
17. Masanori Tamaki, Tatsuya Tominaga, 藤田 結衣, Fumi Kishi, Seiji Kishi, Taichi Murakami, Kojiro Nagai, Hideharu Abe and Toshio Doi :
レチノイン酸はBmp4遺伝子発現を直接制御して糖尿病マウスの糸球体硬化を改善する,
第61回日本腎臓学会学術総会, Jun. 2018.
18. 藤田 結衣, Tatsuya Tominaga, Akiko Sakurai, Kojiro Nagai, Hideharu Abe and Toshio Doi :
BMP4シグナルが作用するポドサイト障害発生機序の解析,
第255回徳島医学会学術集会, Aug. 2017.
19. 田蒔 昌憲, Tatsuya Tominaga, 藤田 結衣, Motokazu Matsuura, Seiji Kishi, Taichi Murakami, Kojiro Nagai, Hideharu Abe and Toshio Doi :
レチノイン酸による糖尿病性糸球体硬化分子BMP4制御機構の検討,
第60回日本腎臓学会学術総会, May 2017.
20. Hiromi Nakagawa, Tatsuya Tominaga, Akiko Sakurai, Yui Fujita, Hideharu Abe, Kojiro Nagai and Toshio Doi :
ポドサイトへのBMP4過剰発現による腎組織への影響,
徳島県臨床検査技師会誌 第40回徳島県医学検査学会抄録集, 28, Dec. 2016.
21. Akiko Sakurai, Hideharu Abe, Tatsuya Tominaga, 三好 雅士 and Toshio Doi :
糖尿病のポドサイト障害におけるCXCR7シグナル異常,
中四国支部医学検査学会(第48回), Nov. 2015.
22. Akiko Sakurai, 林 早苗, Tatsuya Tominaga, 藤田 結衣, Naoko Abe, Toshio Doi and Hideharu Abe :
糖尿病性腎症におけるmiR-21のポドサイトに対するPDCD4制御を介した抗アポトーシス効果,
第36回 日本分子生物学会年会, Dec. 2013.
23. Fujita Yui, Akiko Sakurai, Tatsuya Tominaga, Hayashi Sanae, Naoko Abe, Toshio Doi and Hideharu Abe :
Multiple regulatory pathways of BMP-Smad axis through a sclerosis-specific basic HLH transcription factor in diabetic nephropathy.,
第86回日本生化学会大会, Sep. 2013.
24. Masashi Miyoshi, Kojiro Nagai, Takei Kake, Naoshi Fukushima, Motokazu Matsuura, Eriko Shibata, Kazuhiro Yoshikawa, Kunihisa Yamaguchi, Hirofumi Izaki, Akira Mima, Tatsuya Tominaga, Hideharu Abe and Toshio Doi :
Involvement of Gas6 and its receptor, Dtk in human IgA nephropathy,
第56回日本腎臓学会学術総会, May 2013.
25. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Seiji Kishi, Akira Mima and Toshio Doi :
BMP4シグナル活性化はポドサイト障害およびメサンギウム基質増生を進展させる,
第3回 分子腎臓フォーラム, Sep. 2012.
26. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Seiji Kishi, Akira Mima and Toshio Doi :
糖尿病性腎症におけるポドサイト障害に作用するBMP4の分子機構,
第4回腎疾患と高血圧研究会, Jul. 2012.
27. Eiji Takeda, Hironori Yamamoto, 大谷 彩子, 香西 美奈, 池田 翔子, 中橋 乙起, Yutaka Taketani, Tatsuya Tominaga and Toshio Doi :
1.局所的CYP27B1発現亢進による異所性石灰化(第334回会議研究発表要旨,脂溶性ビタミン総合研究委員会),
Vitamins, Vol.86, No.5, 358-359, Jun. 2012.
(CiNii: 1390282680677126528)
28. Masashi Miyoshi, Kojiro Nagai, Takei Kake, Naoshi Fukushima, Motokazu Matsuura, Eriko Shibata, Satoshi Yamada, Kenji Watase, Kazuhiro Yoshikawa, Fumi Kishi, Seiji Kishi, Kunihisa Yamaguchi, Hirofumi Izaki, Tatsuya Tominaga, Hideharu Abe and Toshio Doi :
Expression of Gas6/Axl in human IgA nephropathy,
第55回日本腎臓学会学術総会, Jun. 2012.
29. Eiji Takeda, Hironori Yamamoto, 大谷 彩子, 香西 美奈, 池田 翔子, 中橋 乙起, Yutaka Taketani, Tatsuya Tominaga and Toshio Doi :
局所的CYP27B1発現亢進による異所性石灰化,
Vitamins, Vol.86, No.5-6, 358-359, Jun. 2012.
30. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Seiji Kishi and Toshio Doi :
ポドサイト障害におけるアポトーシス誘導メカニズムに関する新しい知見,
第4回四国ネフロロジー研究会, Mar. 2012.
31. 大谷 彩子, Hironori Yamamoto, 香西 美奈, 池田 翔子, 中橋 乙起, Yutaka Taketani, Tatsuya Tominaga, Toshio Doi and Eiji Takeda :
リン·ビタミンD代謝異常による異所性石灰化発症の分子機構の解明,
第244回徳島医学会学術集会, Feb. 2012.
32. Tatsuya Tominaga and Hideharu Abe :
BMP4における糖尿病性腎症の発症とアルブミン尿排泄に関する新たな機序,
第54回 日本糖尿病学会年次学術集会, May 2011.
33. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Seiji Kishi and Toshio Doi :
糖尿病性腎症発症とアルブミン尿排泄に関与するBMP4の分子機構,
第52回日本生化学会中国・四国支部例会, May 2011.
34. Tatsuya Tominaga, Hideharu Abe, Taichi Murakami, Seiji Kishi, Kojiro Nagai and 土井 俊夫 :
BMP4における糖尿病性腎症の発症とアルブミン尿排泄機序に関する新たな機序,
Journal of the The Japan Diabetes Society, Vol.54, No.Suppl.1, S-326, Apr. 2011.
35. Tatsuya Tominaga and Hideharu Abe :
腎発生に必須なBMP4が関与する糖尿病性腎症発症の分子機構,
第83回日本生化学会大会, Dec. 2010.
36. Tatsuya Tominaga and Hideharu Abe :
腎発生に必須なBMP4が関与する糖尿病性腎症発症の分子機構,
第33回 日本分子生物学会年会, Dec. 2010.
37. 松原 雄, 安部 秀斉, 上田 乙也, 寺社下 浩一, Tatsuya Tominaga, 後藤 千里, Akira Mima, Kojiro Nagai, 荒木 真, 鳥越 和雄, 松浦 元一, 家原 典之, 木野崎 雅彦, 福島 直, 深津 敦司, 荒井 秀典 and 土井 俊夫 :
IV型コラーゲンの転写制御因子Smad1は骨形成因子BMP4を介して糖尿病性腎症進展に中心的役割を果たす,
糖尿病合併症, Vol.24, No.Suppl.1, 107, Oct. 2010.
38. 吉川 和寛, Hideharu Abe and Tatsuya Tominaga :
CKD患者の血中MGPおよび関連分子と,病態に関する検討,
第55回 日本透析医学会学術集会・総会, Jun. 2010.
39. Norimichi Takamatsu, Hideharu Abe, Tatsuya Tominaga, Kojiro Nagai and Toshio Doi :
地域住民健診におけるアルブミン尿検出の有用性,
第53回 日本腎臓学会学術総会, Jun. 2010.
40. Seiji Kishi, Hideharu Abe, 岸 史, 吉川 和寛, 荒岡 利和, 村上 太一, Tatsuya Tominaga, Kojiro Nagai, Akira Mima, 家原 典之, 秋山 治彦 and 土井 俊夫 :
メサンギウム細胞(MCs)の軟骨細胞形質獲得と低酸素下での不可逆的な腎機能低下の関連,
Japanese Journal of Nephrology, Vol.52, No.3, 322, May 2010.
41. 松原 雄, Hideharu Abe, 上田 乙也, 寺社下 浩一, Akira Mima, 後藤 千里, Tatsuya Tominaga, 荒木 真, 鳥越 和雄, Kojiro Nagai, 家原 典之, 福島 直, 木野崎 雅彦, 深津 敦司, 荒井 秀典 and Toshio Doi :
糖尿病性腎症に関わる新たな治療標的分子の検討,
Japanese Journal of Nephrology, Vol.52, No.3, 288, May 2010.
42. 高松 典通, Hideharu Abe, Tatsuya Tominaga, Kojiro Nagai and 土井 俊夫 :
地域住民健診におけるアルブミン尿検出の有用性,
Japanese Journal of Nephrology, Vol.52, No.3, 299, May 2010.
43. 岸 誠司, Hideharu Abe, 岸 史, 吉川 和寛, 荒岡 利和, 村上 太一, Tatsuya Tominaga, Kojiro Nagai, Akira Mima, 家原 典之, 秋山 治彦 and 土井 俊夫 :
メサンギウム細胞(MCs)の軟骨細胞形質獲得と低酸素下での不可逆的な腎機能低下の関連,
Japanese Journal of Nephrology, Vol.52, No.3, 322, May 2010.
44. 吉川 和寛, Hideharu Abe, Tatsuya Tominaga, Seiji Kishi, 岸 史, 荒岡 利和, Taichi Murakami, 近藤 直樹, Motokazu Matsuura, Kojiro Nagai, Toshio Doi, Masayuki Nakamura, 土田 健司, 水口 潤 and 川島 周 :
CKD患者の血中MGPおよび関連分子と,病態に関する検討,
Journal of Japanese Society for Dialysis Therapy, Vol.43, No.Suppl.1, 682, May 2010.
45. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Akira Mima, 村上 太一, 荒岡 利和, Seiji Kishi, 繁田 令子 and 土井 俊夫 :
糖尿病性腎症の発症・進展にBMP4/Smad1経路が重要な作用をおよぼす,
日本臨床分子医学会学術総会プログラム・抄録集, 66, Apr. 2010.
46. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Akira Mima, 村上 太一, 荒岡 利和, 岸 誠司, 繁田 令子 and 土井 俊夫 :
糖尿病性腎症の発症・進展にBMP4/Smad1経路が重要な作用をおよぼす,
日本臨床分子医学会学術総会プログラム・抄録集, 66, Apr. 2010.
47. Norimichi Takamatsu, Hideharu Abe, Tatsuya Tominaga and 奥本 陽子 :
65歳以上の腎機能低下関連因子--横断的研究による検討,
第21回 日本老年医学会四国地方会総会, Feb. 2010.
48. 村上 太一, Hideharu Abe, Tatsuya Tominaga, 荒岡 利和, 岸 誠司, 高松 典通, Akira Mima, Kojiro Nagai, 高井 義美 and 土井 俊夫 :
糸球体上皮細胞のアクチン骨格制御におけるTrophoblast glycoproteinの機能,
日本生化学会大会プログラム・講演要旨集, 2P-697, Oct. 2009.
49. 荒岡 利和, Hideharu Abe, 松浦 元一, 村上 太一, 岸 誠司, 岸 史, 吉川 和寛, 繁田 令子, Kojiro Nagai, Tatsuya Tominaga and 土井 俊夫 :
2型糖尿病原因遺伝子TCF7L2を介した糖尿病性腎症感受性遺伝子ALK1の分子調節機構の解析,
日本生化学会大会プログラム・講演要旨集, 4T10a-18, Sep. 2009.
50. Tatsuya Tominaga, Hideharu Abe, Kojiro Nagai, Akira Mima, 村上 太一, 荒岡 利和, 岸 誠司, 繁田 令子, 上田 乙也, 後藤 千里, 寺社下 浩一, 木野崎 雅彦, 福島 直 and 土井 俊夫 :
糖尿病性腎症の発症・進展にBMP4/Smad1経路が重要な作用をおよぼす,
日本生化学会大会プログラム・講演要旨集, 4T10a-14, Sep. 2009.
51. 荒岡 利和, 安部 秀斉, Tatsuya Tominaga, 村上 太一, 繁田 令子, Seiji Kishi, 吉川 和寛, 岸 史, 近藤 直樹, 松浦 元一, 高橋 利和, 長井 幸二郎, Akira Mima, 平野 隆弘 and 土井 俊夫 :
糖尿病性腎症の疾患感受性分子ALK1/Smad1のTCF7L2による分子調整機構の解析,
Japanese Journal of Nephrology, Vol.51, No.3, 241, Apr. 2009.
52. 荒岡 利和, 安部 秀斉, 松浦 元一, 村上 太一, Seiji Kishi, Tatsuya Tominaga, 繁田 令子, 吉川 和寛, 岸 史, Akira Mima, 長井 幸二郎, 高橋 利和, 平野 隆弘 and 高松 典通 :
TCF7L2を介した糖尿病性腎症における疾患感受性因子ALK1の分子調整機構の解析,
Journal of the The Japan Diabetes Society, Vol.52, No.Suppl.1, S-220, 2009.
53. Tatsuya Tominaga, 安部 秀斉, 長井 幸二郎, 村上 太一, 荒岡 利和, 岸 誠司, 繁田 令子, 吉川 和寛, 岸 史, 近藤 直樹, 松浦 元一, 高橋 利和, 上田 乙也, 寺社下 浩一, 福島 直, Akira Mima and 土井 俊夫 :
糖尿病性腎症発症・進展に関わる分子機構の解析,
Japanese Journal of Nephrology, Vol.51, No.3, 276, 2009.
54. 村上 太一, 吉川 和寛, 繁田 令子, Seiji Kishi, 荒岡 利和, Tatsuya Tominaga, 安部 秀斉 and 土井 俊夫 :
メサンギウム増殖性腎炎モデルにおける腎糸球体上皮細胞でのアクチン関連分子Trophoblast glycoprotein(Tpbg)の検討,
Seikagaku, Vol.80, No.7, 687, Jul. 2008.
55. 荒岡 利和, 安部 秀斉, Tatsuya Tominaga, 村上 太一 and 土井 俊夫 :
糖尿病性腎症の進行決定因子ALK1の発現調節機構の解析,
Japanese Journal of Nephrology, Vol.50, No.3, 265, 2008.
56. 松浦 元一, 安部 秀斉, Tatsuya Tominaga, 安部 尚子, 高橋 利和, 福島 直 and 土井 俊夫 :
糖尿病性腎症の進行過程におけるElf3の役割,
Japanese Journal of Nephrology, Vol.48, No.3, 286, 2006.
57. Tatsuya Tominaga, 安部 秀斉 and 土井 俊夫 :
早期腎症診断における尿中Smad1の有用性,
Japanese Journal of Medical Technology, Vol.54, No.4, 642, 2005.
58. Tatsuya Tominaga, 安部 秀斉, 松浦 元一 and 土井 俊夫 :
糖尿病性腎症の進行過程におけるBMP4の役割,
Japanese Journal of Nephrology, Vol.47, No.3, 259, 2005.
59. 坂東 美和, 細井 英司, 竹中 真由美, Tatsuya Tominaga, 松本 真弓 and 廣瀬 政雄 :
血液細胞分化過程における血液型H抗原の発現解析,
Japanese Journal of Transfusion Medicine, Vol.50, No.6, 799-800, 2004.

Et cetera, Workshop:

1. Tatsuya Tominaga, Toshio Doi and Kanwar S Yashpal :
メタボリックシンドロームにおける尿細管障害でのMyo-inositol oxygenase (MIOX)の発現メカニズム,
第7回 四国ネフロロジー研究会, Mar. 2015.
2. Eiji Takeda, Hironori Yamamoto, 大谷 彩子, 香西 美奈, 池田 翔子, 中橋 乙起, Yutaka Taketani, Tatsuya Tominaga and Toshio Doi :
局所的CYP27B1発現亢進による異所性石灰化,
第334回脂溶性ビタミン総合研究委員会, Mar. 2012.
3. Tatsuya Tominaga, Hideharu Abe, 長井 幸二郎, Akira Mima and 村上 太一 :
腎発生に必須なBMP4が関与する糖尿病性腎症発症の分子機構,
第3回 四国ネフロロジー研究会, Mar. 2011.
4. Hideharu Abe, Tatsuya Tominaga and Toshio Doi :
BMP4活性化によるアルブミン尿出現の新規メカニズムの解明,
第2回 腎疾患と高血圧研究会, Jul. 2010.
5. Akira Mima, 荒井 秀典, 松原 雄, 金森 弘志, 角 栄里子, 家原 典之, 深津 敦司, Hideharu Abe, 高橋 利和, Tatsuya Tominaga, 北 徹 and Toshio Doi :
アンギオテンシンII受容体拮抗薬は糖尿病性腎症においてSrc/Smad1系を抑制することにより糸球体硬化を抑制する,
シンポジウム糖尿病, Oct. 2005.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 骨形成環境による腫瘍排他的ニッチの分子機序の解明:新たながん治療戦略の可能性 (Project/Area Number: 24K02643 )
  • 多元的フェロトーシス治療に基づく慢性腎臓病治療戦略の開発 (Project/Area Number: 23K07674 )
  • ポドサイトの活性化シグナルの解析による各種腎障害の鑑別法の開発 (Project/Area Number: 21K07367 )
  • Elucidation of the molecular mechanisms responsible for the recent increase in DKD (Project/Area Number: 20K08593 )
  • The role of autophagy in mesangial cells in the development of chronic kidney disease (Project/Area Number: 19K08705 )
  • 糖尿病における進行性腎障害の病態特異的バイオマーカー樹立と修復機構解明 (Project/Area Number: 18K08245 )
  • Identification of specific podocyte-damaging molecules in diabetic nephropathy and establishment of urinary biomarkers (Project/Area Number: 18K07415 )
  • Development of new CKD therapeutic agent targeting cytokine processing enzyme (Project/Area Number: 17K09700 )
  • The role of mesangial cells in glomeruli formation and the development of diabetic kidney disease (Project/Area Number: 16K09619 )
  • 慢性腎臓病(CKD)における糖尿病血管合併症の成因解明 (Project/Area Number: 24790848 )
  • Role of cell signaling pathway in mesangial cells in the progression of chronic kidney disease (Project/Area Number: 24591202 )
  • Establishment of non-invasive diagnostic method for CKD by using urinary exosomes. (Project/Area Number: 23659445 )
  • Development of Specific Biomarker and Molecular Targeting Therapy for Diabetic Nephropathy by RAS-independent Pathway (Project/Area Number: 22390169 )
  • Analysis for novel role of Tpbg in podocyte in glomerulonephritis. (Project/Area Number: 21591032 )
  • Establishment and evaluation of the measurement of serum Smad1 in diabetic vascular complications. (Project/Area Number: 21590628 )
  • Search by Researcher Number (80425446)