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Tokushima UniversityInstitute of Advanced Medical Sciences重点研究部門
Tokushima UniversityGraduate School of Medical SciencesMedical ScienceCourse of Preventive Medicine
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Research Activity

Her Web Page

Field of Study

Medicine

Subject of Study

Book / Paper

Book:

1. Izumi Ohigashi, Kenta Kondou and Yousuke Takahama :
免疫生物学(原書第9版) 監訳 笹月健彦,吉開泰信,
Nankodo, 東京都, Mar. 2019.
2. Izumi Ohigashi and Yousuke Takahama :
Thymocyte-mTEC cross talk for self-tolerance in T cells.,
Elsevier, Apr. 2016.

Academic Paper (Judged Full Paper):

1. KD James, DF Legler, V Purvanov, Izumi Ohigashi, Yousuke Takahama, SM Parnell, AJ White, WE Jenkinson and G Anderson :
Medullary stromal cells synergize their production and capture of CCL21 for T-cell emigration from neonatal mouse thymus,
Blood Advances, Vol.5, No.1, 99-112, 2021.
(DOI: 10.1182/bloodadvances.2020003192.)
2. M Lachén-Montes, N Mendizuri, K Ausín, A Pérez-Mediavilla, M Azkargorta, I Iloro, F Elortza, Hiroyuki Kondo, Izumi Ohigashi, I Ferrer, R la Torre de, P Robledo, J Fernández-Irigoyen and E Santamaría :
Smelling the Dark Proteome: Functional Characterization of PITH Domain-Containing Protein 1 (C1orf128) in Olfactory Metabolism,
Journal of Proteome Research, Vol.19, No.12, 4826-4843, 2020.
(DOI: 10.1021/acs.jproteome.0c00452,   PubMed: 33185454,   Elsevier: Scopus)
3. JE Cowan, Yousuke Takahama, A Bhandoola and Izumi Ohigashi :
Postnatal involution and counter-involution of the thymus. Frontiers in Immunology,
Frontiers in Immunology, Vol.11, No.897, 2020.
(Tokushima University Institutional Repository: 115261,   DOI: 10.3389/fimmu.2020.00897,   PubMed: 32477366)
4. B Lucas, AJ White, EJ Cosway, SM Parnell, KD James, ND Jones, Izumi Ohigashi, Yousuke Takahama, WE Jenkinson and G Anderson :
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells,
Nature Communications, Vol.11, No.1, 2020.
(DOI: 10.1038/s41467-020-16041-x,   PubMed: 32366944,   Elsevier: Scopus)
5. Hiroyuki Kondo, Takafumi Matsumura, Mari Kaneko, Kenichi Inoue, Hidetaka Kosako, Masahito Ikawa, Yousuke Takahama and Izumi Ohigashi :
PITHD1 is a proteasome-interacting protein essential for male fertilization,
The Journal of Biological Chemistry, Vol.295, No.6, 1658-1672, 2020.
(Tokushima University Institutional Repository: 114611,   DOI: 10.1074/jbc.RA119.011144,   PubMed: 31915251)
6. Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam and Avinash Bhandoola :
Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth,
Nature Communications, Vol.10, No.1, 5498, 2019.
(Tokushima University Institutional Repository: 115228,   DOI: 10.1038/s41467-019-13465-y,   PubMed: 31792212,   Elsevier: Scopus)
7. Izumi Ohigashi, Yu Tanaka, Kenta Kondou, Sayumi Fujimori, Hiroyuki Kondo, Amy Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako and Yousuke Takahama :
Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells.,
Cell Reports, Vol.29, No.9, 2901-2916.e6, 2019.
(Tokushima University Institutional Repository: 115049,   DOI: 10.1016/j.celrep.2019.10.079,   PubMed: 31775054)
8. Shahina Umme Khanom, Izumi Ohigashi, Sayumi Fujimori, Kenta Kondou, Kensuke Takada and Yousuke Takahama :
TCR affinity for in vivo peptide-induced thymic positive selection fine-tunes TCR responsiveness of peripheral CD8+ T cells,
The Journal of Immunology, Vol.203, No.4, 881-887, 2019.
(Tokushima University Institutional Repository: 113696,   DOI: 10.4049/jimmunol.1900097,   PubMed: 31235550,   Elsevier: Scopus)
9. Kenta Kondou, Izumi Ohigashi and Y Takahama :
Thymus machinery for T-cell selection,
International Immunology, Vol.31, No.3, 119-125, 2019.
(DOI: 10.1093/intimm/dxy081,   PubMed: 30476234,   Elsevier: Scopus)
10. Yousuke Takahama, Izumi Ohigashi, Shigeo Murata and Keiji Tanaka :
Thymoproteasome and peptidic self,
Immunogenetics, Vol.71, No.3, 217-221, 2019.
(DOI: 10.1007/s00251-018-1081-3,   PubMed: 30324237,   Elsevier: Scopus)
11. A Takeuchi, M Ozawa, Y Kanda, M Kozai, Izumi Ohigashi, Y Kurosawa, MA Rahman, T Kawamura, Y Shichida, E Umemoto, M Miyasaka, B Ludewig, Y Takahama, T Nagasawa and T Katakai :
A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node,
Frontiers in Immunology, Vol.9, 2196, 2018.
(Tokushima University Institutional Repository: 114469,   DOI: 10.3389/fimmu.2018.02196,   PubMed: 30333825,   Elsevier: Scopus)
12. Emilie J. Cosway, Izumi Ohigashi, Karin Schauble, Sonia M. Parnell, William E. Jenkinson, Sanjiv Luther, Yousuke Takahama and Graham Anderson :
Formation of the intrathymic dendritic cell pool requires CCL21-mediated recruitment of CCR7+ progenitors to the thymus,
The Journal of Immunology, Vol.201, No.2, 516-523, 2018.
(Tokushima University Institutional Repository: 114497,   DOI: 10.4049/jimmunol.1800348,   PubMed: 29784760,   Elsevier: Scopus)
13. Mie Sakata, Izumi Ohigashi and Yousuke Takahama :
Cellularity of Thymic Epithelial Cells in the Postnatal Mouse.,
The Journal of Immunology, Vol.200, No.4, 1382-1388, 2018.
(DOI: 10.4049/jimmunol.1701235,   PubMed: 29298829,   Elsevier: Scopus)
14. Mina Kozai, Yuki Kubo, Tomoya Katakai, Hiroyuki Kondo, Hiroshi Kiyonari, Karin Schaeuble, Sanjiv A. Luther, Naozumi Ishimaru, Izumi Ohigashi and Yousuke Takahama :
Essential role of CCL21 in establishment of central self-tolerance in T cells,
The Journal of Experimental Medicine, Vol.214, No.7, 1925-1935, 2017.
(Tokushima University Institutional Repository: 110168,   DOI: 10.1084/jem.20161864,   PubMed: 28611158)
15. Izumi Ohigashi, Yuki Ohte, Kazuya Setoh, Hiroshi Nakase, Akiko Maekawa, Hiroshi Kiyonari, Yoko Hamazaki, Miho Sekai, Tetsuo Sudo, Yasuharu Tabara, Hiromi Sawai, Yosuke Omae, Rika Yuliwulandari, Yasuhito Tanaka, Masashi Mizokami, Hiroshi Inoue, Masanori Kasahara, Nagahiro Minato, Katsushi Tokunaga, Keiji Tanaka, Fumihiko Matsuda, Shigeo Murata and Yousuke Takahama :
A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production,
JCI Insight, Vol.2, No.10, 2017.
(Tokushima University Institutional Repository: 113736,   DOI: 10.1172/jci.insight.93664,   PubMed: 28515360)
16. Uddin Myn Muhammad, Izumi Ohigashi, Ryo Motosugi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki, Yasumasa Nishito, Immanuel Rode, Keiji Tanaka, Tatsuya Takemoto, Shigeo Murata and Yousuke Takahama :
Foxn1-5t transcriptional axis controls CD8+ T-cell production in the thymus.,
Nature Communications, Vol.8, 14419, 2017.
(Tokushima University Institutional Repository: 110920,   DOI: 10.1038/ncomms14419,   PubMed: 28176764,   Elsevier: Scopus)
17. Izumi Ohigashi, Mina Kozai and Yousuke Takahama :
Development and developmental potential of cortical thymic epithelial cells,
Immunological Reviews, Vol.271, No.1, 10-22, 2016.
(Tokushima University Institutional Repository: 113737,   DOI: 10.1111/imr.12404,   PubMed: 27088904,   Elsevier: Scopus)
18. CE Mayer, S Zuklys, S Zhanybekova, Izumi Ohigashi, HY Teh, SN Sansom, N Shikama-Dorn, K Hafen, IC Macaulay, ME Deadman, CP Ponting, Yousuke Takahama and GA Hollander :
Dynamic spatio-temporal contribution of single β5t+ cortical epithelial precursors to the thymus medulla,
European Journal of Immunology, Vol.46, No.4, 846-856, 2016.
(DOI: 10.1002/eji.201545995,   PubMed: 26694097)
19. Izumi Ohigashi and Yousuke Takahama :
Thymocyte-mTEC cross talk for self-tolerance in T cells,
Encyclopedia of Immunology, Vol.1, 263-267, 2016.
(Elsevier: Scopus)
20. Izumi Ohigashi and Yousuke Takahama :
Flow Cytometry Analysis of Thymic Epithelial Cells and Their Subpopulations,
Methods in Molecular Biology, Vol.1323, 65-73, 2016.
(DOI: 10.1007/978-1-4939-2809-5_5,   PubMed: 26294398)
21. Izumi Ohigashi, Saulius Zuklys, Mie Sakata, Carlos E. Mayer, Yoko Hamazaki, Nagahiro Minato, Georg A Hollander and Yousuke Takahama :
Adult thymic medullary epithelium is maintained and regenerated by lineage-restricted cells rather than bipotent progenitors,
Cell Reports, Vol.13, No.7, 1432-1443, 2015.
(Tokushima University Institutional Repository: 113738,   DOI: 10.1016/j.celrep.2015.10.012,   PubMed: 26549457,   Elsevier: Scopus)
22. L Nuno Alves, Yousuke Takahama, Izumi Ohigashi, R Ana Ribeiro, Song Baik, Graham Anderson and E William Jenkinson :
Serial progression of cortical and medullary thymic epithelial microenvironments.,
European Journal of Immunology, Vol.44, No.1, 16-22, 2014.
(DOI: 10.1002/eji.201344110,   PubMed: 24214487,   Elsevier: Scopus)
23. Kensuke Takada, Izumi Ohigashi, Michiyuki Kasai, Hiroshi Nakase and Yousuke Takahama :
Development and function of cortical thymic epithelial cells.,
Current Topics in Microbiology and Immunology, Vol.373, 1-17, 2014.
(DOI: 10.1007/82_2013_322,   PubMed: 23612989,   Elsevier: Scopus)
24. Izumi Ohigashi and Yousuke Takahama :
CCRL1 marks heterogeneity in cortical and medullary thymic epithelial cells.,
European Journal of Immunology, Vol.44, No.10, 2872-2875, 2014.
(DOI: 10.1002/eji.201445091,   PubMed: 25216053,   Elsevier: Scopus)
25. Naoko Matsui, Izumi Ohigashi, Keijirou Tanaka, Mie Sakata, Takahiro Furukawa, Yasushi Nakagawa, Kazuya Kondo, Tetsuya Kitagawa, Sumimasa Yamashita, Yoshiko Nomura, Yousuke Takahama and Ryuji Kaji :
Increased number of Hassall's corpuscles in myasthenia gravis patients with thymic hyperplasia.,
Journal of Neuroimmunology, Vol.269, No.1-2, 56-61, 2014.
(DOI: 10.1016/j.jneuroim.2014.01.011,   PubMed: 24556356,   Elsevier: Scopus)
26. A Joy Williams, Jingjing Zhang, Hyein Jeon, Takeshi Nitta, Izumi Ohigashi, David Klug, J Michael Kruhlak, Baishakhi Choudhury, O Susan Sharrow, Larry Granger, Anthony Adams, A Michael Eckhaus, Rhiannon S Jenkinson, R Ellen Richie, E Ronald Gress, Yousuke Takahama and J Richard Hodes :
Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathways.,
The Journal of Immunology, Vol.192, No.2, 630-640, 2014.
(DOI: 10.4049/jimmunol.1302550,   PubMed: 24337745,   Elsevier: Scopus)
27. Rhiannon S Jenkinson, A Joy Williams, Hyein Jeon, Jingjing Zhang, Takeshi Nitta, Izumi Ohigashi, Michael Kruhlak, Saulius Zuklys, Susan Sharrow, Anthony Adams, Larry Granger, Yongwon Choi, Ulrich Siebenlist, A Gail Bishop, A Georg Hollander, Yousuke Takahama and J Richard Hodes :
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.110, No.52, 21107-21112, 2013.
(DOI: 10.1073/pnas.1314859111,   PubMed: 24324158)
28. Izumi Ohigashi, Saulius Zuklys, Mie Sakata, E Carlos Mayer, Saule Zhanybekova, Shigeo Murata, Keiji Tanaka, A Georg Holländer and Yousuke Takahama :
Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cells.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.110, No.24, 9885-9890, 2013.
(DOI: 10.1073/pnas.1301799110,   PubMed: 23720310)
29. Enkhsaikhan Lkhagvasuren, Mie Sakata, Izumi Ohigashi and Yousuke Takahama :
Lymphotoxin receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.,
The Journal of Immunology, Vol.190, No.10, 5110-5117, 2013.
(Tokushima University Institutional Repository: 105886,   DOI: 10.4049/jimmunol.1203203,   PubMed: 23585674)
30. Takeshi Nitta, Izumi Ohigashi and Yousuke Takahama :
The development of T lymphocytes in fetal thymus organ culture.,
Methods in Molecular Biology, Vol.946, 85-102, 2013.
(DOI: 10.1007/978-1-62703-128-8_6,   PubMed: 23179827)
31. NM Roberts, AJ White, WE Jenkinson, G Turchinovich, K Nakamura, DR Withers, FM McConnell, GE Desanti, C Benezech, SM Parnell, AF Cunningham, M Paolino, J Penninger, K Simon, T Nitta, Izumi Ohigashi, Yousuke Takahama, JH Caamano, AC Hayday, PJ Lane, EJ Jenkinson and G Anderson :
Rank signaling links the development of invariant γδ T cell progenitors and Aire+ medullary epithelium.,
Immunity, Vol.36, No.3, 427-437, 2012.
(DOI: 10.1016/j.immuni.2012.01.016,   PubMed: 22425250)
32. Izumi Ohigashi, Takeshi Nitta, E Lkhagvasuren, H Yasuda and Yousuke Takahama :
Effects of RANKL on the thymic medulla,
European Journal of Immunology, Vol.41, No.7, 1822-1827, 2011.
(DOI: 10.1002/eji.201141480,   PubMed: 21706487)
33. Yu Lei, Adiratna Mat Ripen, Naozumi Ishimaru, Izumi Ohigashi, Takashi Nagasawa, Lukas T. Jeker, Michael R. Bösl, Georg A. Holländer, Yoshio Hayashi, Rene Waal de Malefyt, Takeshi Nitta and Yousuke Takahama :
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development,
The Journal of Experimental Medicine, Vol.208, No.2, 383-394, 2011.
(DOI: 10.1084/jem.20102327,   PubMed: 21300913)
34. Takeshi Nitta, Izumi Ohigashi, Yasushi Nakagawa and Yousuke Takahama :
Cytokine crosstalk for thymic medulla formation,
Current Opinion in Immunology, Vol.23, No.2, 190-197, 2011.
(DOI: 10.1016/j.coi.2010.12.002,   PubMed: 21194915)
35. Izumi Ohigashi, Yuki Yamasaki, Tsukasa Hirashima and Yousuke Takahama :
Identification of the Transgenic Integration Site in Immunodeficient tgϵ26 Human CD3ϵ Transgenic Mice,
PLoS ONE, Vol.5, No.12, e14391, 2010.
(DOI: 10.1371/journal.pone.0014391,   PubMed: 21203507)
36. Naoko Matsui, Shunya Nakane, Fumi Saitou, Izumi Ohigashi, Yasushi Nakagawa, Hirotsugu Kurobe, Hiromitsu Takizawa, Takao Mitsui, Kazuya Kondo, Tetsuya Kitagawa, Yousuke Takahama and Ryuji Kaji :
Undiminished regulatory T cells in the thymus of myathenia gravis patients,
Neurology, Vol.74, No.10, 816-820, 2010.
(DOI: 10.1212/WNL.0b013e3181d31e47,   PubMed: 20211905)
37. DA Sultana, Shuhei Tomita, M Hamada, Y Iwanaga, Y Kitahama, NV Khang, S Hirai, Izumi Ohigashi, S Nitta, T Amagai, S Takahashi and Yousuke Takahama :
Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development,
Blood, Vol.113, No.13, 2976-2987, 2009.
(DOI: 10.1182/blood-2008-06-164921,   PubMed: 19164599)
38. Yu Hikosaka, Takeshi Nitta, Izumi Ohigashi, Kouta Yano, Naozumi Ishimaru, Yoshio Hayashi, Mitsuru Matsumoto, Koichi Matsuo, Josef M Penninger, Hiroshi Takayanagi, Yoshifumi Yokota, Hisakata Yamada, Yasunobu Yoshikai, Jun-ichiro Inoue, Taishin Akiyama and Yousuke Takahama :
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.,
Immunity, Vol.29, No.3, 438-450, 2008.
(DOI: 10.1016/j.immuni.2008.06.018,   PubMed: 18799150)
39. Takeshi Nitta, Mariam Nasreen, Takafumi Seike, Atsushi Goji, Izumi Ohigashi, Tadaaki Miyazaki, Tsutomu Ohta, Masamoto Kanno and Yousuke Takahama :
IAN family critically regulates survival and development of T lymphocytes,
PLoS Biology, Vol.4, No.4, e103-e115, 2006.
(DOI: 10.1371/journal.pbio.0040103,   PubMed: 16509771)
40. Noriko Mizusawa, Tomoko Hasegawa, Izumi Ohigashi, Chisato Kosugi, Nagakatsu Harada, Mitsuo Itakura and Katsuhiko Yoshimoto :
Differentiation Penotypes of Pancreatic Islet β- and α-cells are Closely Related with Homeotic Genes and a Group of Differentially Expressed Genes.,
Gene, Vol.331, No.28, 53-63, 2004.
(Tokushima University Institutional Repository: 112035,   DOI: 10.1016/j.gene.2004.01.016,   PubMed: 15094191)

Review, Commentary:

1. Yousuke Takahama, Izumi Ohigashi, Song Baik and Graham Anderson :
Generation of diversity in thymic epithelial cells,
Nature Reviews. Immunology, Vol.17, No.5, 295-305, May 2017.
(DOI: 10.1038/nri.2017.12,   PubMed: 28317923)
2. Izumi Ohigashi and Yousuke Takahama :
T細胞の自己寛容を確立する胸腺髄質微小環境,
自己免疫疾患の発症機構と治療 実験医学増刊号, 30-36, 2015.
3. Izumi Ohigashi and Yousuke Takahama :
XCL1と胸腺におけるnTregの生成,
Infection, Inflammation & Immunity, Vol.41, 60-62, 2011.
4. Izumi Ohigashi and Yousuke Takahama :
Thymic cortical epithelial cells specific expression of thymoproteasome,
Clinical immunology & allergology, Vol.56, No.3, 232-237, Sep. 2011.
(CiNii: 40019017856)

Proceeding of International Conference:

1. Izumi Ohigashi :
Trnas-omics profiling of thymic epithelial cells,
The 4th Symposium of the inter-university research network for trans-omics medicine, Nov. 2019.
2. Sayumi Fujimori, Izumi Ohigashi, Takahama Yousuke and Takada Shinji :
Role of β-catenin in thymic epithelial progenies of β5t positive progenitors,
ThymE: T cell and thymus biology, May 2019.
3. Izumi Ohigashi, Yu Tanaka, Kenta Kondou, Sayumi Fujimori, Amy C. Palin, Hiroyuki Kondo, Hidetaka Kosako and Yousuke Takahama :
Trans-omics impact of thymoproteasome in cortical thymic epithelial cells,
ThymE: T cell and thymus biology, May 2019.
4. Izumi Ohigashi and Yousuke Takahama :
Human PSMB11 polymorphisms that affect thymoproteasome processing and CD8+ T cell generation,
8th THYMOZ, Mar. 2018.
5. Uddin Myn, Izumi Ohigashi and Yousuke Takahama :
Foxn1-b5t transcriptional axis controls CD8+ T-cell production in the thymus,
IMMUNOLOGY 2017, AAI Annual Meeting, May 2017.
6. Kondo Hiroyuki, Izumi Ohigashi, Kozai Mina, Kubo Yuki, Katakai Tomoya, Luther A. Sanjiv and Yousuke Takahama :
Essential role of CCL21 in establishment of central self-tolerance in T cells,
7th International Workshop of Kyoto T Cell Conference, Mar. 2017.
7. Izumi Ohigashi, Ohte Yuki, Setoh Kazuya, Matsuda Fumihiko, Murata Shigeo and Yousuke Takahama :
A human Psmb11 polymorphism affects molecular processing of thymoproteasome and thymic production of CD8+ T cells,
7th International Workshop of Kyoto T Cell Conference, Mar. 2017.
8. Sayumi Fujimori, Izumi Ohigashi, Tatsuya Takemoto, Yousuke Takahama and Takada Shinji :
Activation of Wnt/β-catenin signaling in thymic epithelial progenitors,
7th International Workshop of Kyoto T Cell Conference, Kyoto, Mar. 2017.
9. Kozai Mina, Izumi Ohigashi and Yousuke Takahama :
CCL21 regulates T-cell self-tolerance in thymic medulla,
11th International Symposium of The Institute Network Frontiers in Biomedical Sciences, Jan. 2017.
10. Izumi Ohigashi, Uddin Myn, Tatsuya Takemoto and Yousuke Takahama :
Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus,
11th International Symposium of The Institute Network Frontiers in Biomedical Sciences, Jan. 2017.
11. Izumi Ohigashi and Yousuke Takahama :
Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus,
The Fifth Bizan Immunology symposium, 徳島県徳島市, Mar. 2016.
12. Izumi Ohigashi and Yousuke Takahama :
Adult thymus medullary epithelium is maintained and regenerated by lineage restricted cells rather than bipotent progenitors,
The Fourth BIZAN Immunology Symposium at University of TokushimaImmune System Development, Deviation, and Regulation, Jan. 2015.
13. Izumi Ohigashi, Zuklys Saulius, Hollander Georg and Yousuke Takahama :
mTECs derived from embryonic and postnatal beta5t+ progenitors,
The 7th ThymOZ International Conference, Apr. 2014.
14. Izumi Ohigashi and Yousuke Takahama :
Development and developmental potential of 5t-expressing thymic epithelial cells,
The Third Bizan Immunology Symposium at The University of Tokushima (BISUT3) "Immune System Development, Deviation, and Regulation", Feb. 2014.
15. Yousuke Takahama and Izumi Ohigashi :
Serial development of cortical and medullary thymic epithelia,
Fourth Synthetic Immunology WorkshopEngineering in Immunity, Nov. 2013.
16. Naoko Matsui, Izumi Ohigashi, Yousuke Takahama and Ryuji Kaji :
Increased Hassalls corpuscles in myasthenia gravis patients carrying thymic hyperplasia,
Myasthenia 2013, Paris, Jul. 2013.
17. Yousuke Takahama and Izumi Ohigashi :
Development and developmental potential of 5t-expressing thymic epithelial cells,
KTCC 2013 International Workshop on T Lymphocytes, Jun. 2013.
18. Lkhagvasuren Enkhsaikhan, Sakata Mie, Izumi Ohigashi and Yousuke Takahama :
Lymphotoxin receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells,
KTCC 2013 International Workshop on T Lymphocytes, Jun. 2013.
19. Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, Nomura Yoshiko, Yousuke Takahama and Ryuji Kaji :
Increased Hassalls Corpuscles In Myasthenia Gravis Patients Carrying Thymic Hyperplasia,
11th International congress of neuroimmunology, Nov. 2012.
20. Izumi Ohigashi, Takeshi Nitta, ENOMOTO Tetsuro, TOMIMORI Toshiya, YASUDA Hisataka and Yousuke Takahama :
RANKL PROMOTES THYMIC MEDULLA FORMATION,
The 2nd Workshop of Synthetic Immunology, Kyoto, Dec. 2010.

Proceeding of Domestic Conference:

1. Yohhei Yamamoto, Naoko Matsui, 織田 史子, 小澤 由希子, 金井 哲也, 鵜沢 顕之, Izumi Ohigashi, Kazuya Kondo, 桑原 聡, 山村 隆 and Yuishin Izumi :
重症筋無力症患者の胸腺ではプラズマブラストが増加している,
第32回日本神経免疫学会学術集会, Oct. 2020.
2. Yohhei Yamamoto, Naoko Matsui, 織田 史子, 小澤 由紀子, 金井 哲也, 鵜澤 顕之, Izumi Ohigashi, Kazuya Kondo, 桑原 聡, 山村 隆 and Yuishin Izumi :
重症筋無力症患者の胸腺ではプラズマブラストが増加している,
第32回日本神経免疫学会学術集会, Oct. 2020.
3. Yohhei Yamamoto, Naoko Matsui, Izumi Ohigashi, Kazuya Kondo and Yuishin Izumi :
重症筋無力症患者の胸腺におけるB細胞分画と濾胞性ヘルパーT細胞の解析,
第39回日本胸腺研究会, Feb. 2020.
4. Izumi Ohigashi, Hidetaka Kosako and Yousuke Takahama :
Trans-omics impact of thymoproteasome in cortical thymic epithelial cells,
第42回日本分子生物学会年会, Dec. 2019.
5. Sayumi Fujimori, Izumi Ohigashi, Yousuke Takahama and 高田 慎治 :
Fine-tuning of the β-catenin-dependent signaling in mouse thymic epithelial cells is required for thymic development,
第42回日本分子生物学会年会, Dec. 2019.
6. 近藤 博之, 松村 貴史, Hidetaka Kosako, 伊川 正人, Yousuke Takahama and Izumi Ohigashi :
新規プロテアソーム会合因子PITHD1は精子形成を制御する,
第42回日本分子生物学学会年会, Dec. 2019.
7. Yohhei Yamamoto, Naoko Matsui, 織田 史子, 小澤 由希子, 金井 哲也, 鵜沢 顕之, Izumi Ohigashi, Hiroyuki Kondo, Kazuya Kondo, Tetsuya Kitagawa, 桑原 聡, 山村 隆, Yuishin Izumi and Ryuji Kaji :
重症筋無力症患者の胸腺におけるB細胞分画と濾胞性ヘルパーT細胞の解析,
第31回日本神経免疫学会学術集会, Vol.24, No.1, 140, Sep. 2019.
8. Yamamoto Yohei, Naoko Matsui, Oda Fumiko, Ozawa Yukiko, Kanai Tetsuya, Uzawa Akiyuki, Izumi Ohigashi, Kondo Hiroyuki, Kazuya Kondo, Tetsuya Kitagawa, Yamamura Takashi, Kuwabara Satoshi, Yuishin Izumi and Ryuji Kaji :
B cell subsets and T follicular helper cells in myasthenia gravis thymus,
第60回日本神経学会学術大会, May 2019.
9. 近藤 博之, 松村 貴史, Hidetaka Kosako, 伊川 正人, Yousuke Takahama and Izumi Ohigashi :
プロテアソームに会合する新規分子PITHD1の機能解析,
第41回日本分子生物学会年会, Nov. 2018.
10. Sayumi Fujimori, Izumi Ohigashi, Takada Shinji and Yousuke Takahama :
Enforced activation of β-catenin signaling in mouse thymic epithelial cells induces thymic dysplasia,
The 41st Annual Meeting of the Molecular Biology Society of Japan, Nov. 2018.
11. Yamamoto Yohhei, Naoko Matsui, Kazuya Kondo, Izumi Ohigashi, Yousuke Takahama, Nakagawa Hidewaki, Yuishin Izumi and Ryuji Kaji :
Analysis of human thymic epithelial cells,
第59回日本神経学会学術大会, May 2018.
12. Izumi Ohigashi, Naozumi Ishimaru, Katakai Tomoya and Yousuke Takahama :
Essential role of CCL21 in establishment of central tolerance in T cells,
第40回 日本分子生物学会年会, Dec. 2017.
13. Sayumi Fujimori, Izumi Ohigashi, Tatsuya Takemoto, 高田 慎治 and Yousuke Takahama :
マウス胸腺皮質上皮細胞亜集団におけるWnt/β-cateninシグナル経路の活性化,
第40回日本分子生物学会年会, Dec. 2017.
14. Naoko Matsui, Izumi Ohigashi, Myn Muhammad Uddin, Kaito Sasaka, Yohhei Yamamoto, Takahiro Furukawa, Kazuya Kondo, 中川 英刀, Ryuji Kaji and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第29回日本神経免疫学会学術集会, Oct. 2017.
15. Naoko Matsui, Izumi Ohigashi, Yamamoto Yohei, Kazuya Kondo, Yousuke Takahama and Ryuji Kaji :
Approach for analysis of human thymic epithelial cells,
XX World Congress of Neurology, Sep. 2017.
16. Uddin Myn, Izumi Ohigashi and Yousuke Takahama :
Foxn1-binding cis-regulatory element required for optimal CD8+ T cell production in the thymus,
第46回日本免疫学会学術集会, Dec. 2016.
17. Izumi Ohigashi, Tatsuya Takemoto and Yousuke Takahama :
胸腺におけるCD8+ T細胞生成を制御するFoxn1結合シス制御領域の同定,
第39回日本分子生物学会年会, Dec. 2016.
18. Sayumi Fujimori, Izumi Ohigashi, Tatsuya Takemoto, Yousuke Takahama and 高田 慎治 :
マウス胸腺上皮細胞におけるWnt/β-cateninシグナル経路の時空間的活性化,
第39回日本分子生物学会年会, Dec. 2016.
19. 金 喜栄, Naoko Matsui, Izumi Ohigashi, 古川 貴大, Yousuke Takahama and Ryuji Kaji :
ヒト胸腺を用いた胸腺上皮細胞解析への試み,
第57日本神経学会学術大会, 367, May 2016.
20. Myn Uddin, Izumi Ohigashi and Yousuke Takahama :
Foxn1-binding cis-regulatory element for optimal CD8+ T cell production in the thymus,
第26回 Kyoto T cell Conference, May 2016.
21. Naoko Matsui, Izumi Ohigashi, Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第35回日本胸腺研究会, Feb. 2016.
22. Mina Kozai, Izumi Ohigashi and Yousuke Takahama :
Defective self-tolerance in CCL21-deficient mice,
第44回日本免疫学会総会学術集会, Nov. 2015.
23. Izumi Ohigashi and Yousuke Takahama :
Differentiation potential of b5t+ thymic epithelial progenitors,
第44回日本免疫学会総会学術集会, Nov. 2015.
24. Izumi Ohigashi and Yousuke Takahama :
成体の胸腺髄質上皮は髄質系列細胞によって維持・再生される,
第25回 Kyoto T Cell Conference, May 2015.
25. Bongju Kim, Izumi Ohigashi and Yousuke Takahama :
胸腺上皮細胞におけるミトコンドリアの役割,
第92回日本生理学会大会, Mar. 2015.
26. Bongju Kim, Izumi Ohigashi and Yousuke Takahama :
Role of mitochondria in thymic epithelial cells,
第43回日本免疫学会学術集会, Dec. 2014.
27. Bongju Kim, Izumi Ohigashi and Yousuke Takahama :
Role of mitochondria in thymic epithelial cells,
第43回日本免疫学会学術集会, Dec. 2014.
28. Izumi Ohigashi and Yousuke Takahama :
5t+ progenitors contribute to the maintenance and regeneration of medullary thymic epithelial cells,
第43回日本免疫学会学術集会, Dec. 2014.
29. 香西 美奈, Izumi Ohigashi and Yousuke Takahama :
Defective T cell tolerance in CCL21 knockout mice,
第43回日本免疫学会学術集会, Dec. 2014.
30. 香西 美奈, Izumi Ohigashi and Yousuke Takahama :
CCL21Ser欠損マウスにおける免疫異常,
第13回四国免疫フォーラム, Jun. 2014.
31. Izumi Ohigashi and Yousuke Takahama :
髄質上皮細胞の維持と再生におけるβ5t陽性前駆細胞の寄与,
第24回 Kyoto T Cell Conference, May 2014.
32. Izumi Ohigashi and Yousuke Takahama :
Development and developmental potential of5t-expressing thymic epithelial cells,
第42回日本免疫学会学術集会, Dec. 2013.
33. Izumi Ohigashi and Yousuke Takahama :
胸腺皮質上皮細胞特異的β5tおよび髄質上皮細胞に発現するCCL21aの発現トレーサー実験による胸腺上皮細胞分化機構の解析,
第37回日本リンパ学会総会, Jun. 2013.
34. Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, Yousuke Takahama and Ryuji Kaji :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第32回日本胸腺研究会, Feb. 2013.
35. Naoko Matsui, Izumi Ohigashi and Yousuke Takahama :
Increased Hassalls corpuscles in myasthenia gravis patients carrying thymic hyperplasia,
41st Annual Meeting of The Japanese Society for Immunology, Dec. 2012.
36. Naoko Matsui, Izumi Ohigashi and Yousuke Takahama :
Increased Hassalls Corpuscles In Myasthenia Gravis Patients Carrying Thymic Hyperplasia,
第41回日本免疫学会学術集会, Dec. 2012.
37. Izumi Ohigashi and Yousuke Takahama :
Analysis of cortical and medullary bifurcation mechanisms in thymic epithelial cells using cortical thymic epithelial cell-specific beta 5t-Cre knock-in mice,
第41回日本免疫学会学術集会, Dec. 2012.
38. Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, 野村 芳子, Yousuke Takahama and Ryuji Kaji :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第24回日本神経免疫学会学術集会, Sep. 2012.
39. Naoko Matsui, Izumi Ohigashi, Kazuya Kondo, 野村 芳子, Yousuke Takahama and Ryuji Kaji :
重症筋無力症の過形成胸腺ではハッサル小体が増加している,
第24回日本神経免疫学会, Sep. 2012.
40. Izumi Ohigashi and Yousuke Takahama :
胸腺皮質上皮細胞特異的b5t遺伝子座にCreをノックインしたマウスの作製,
第22回 Kyoto T Cell Conference, Jul. 2012.
41. Naoko Matsui, Izumi Ohigashi, 野村 芳子, Yousuke Takahama and Ryuji Kaji :
重症筋無力症患者胸腺における制御性T細胞ならびにハッサル小体の役割,
Clinical Neurology, Vol.51, No.12, 1300, Dec. 2011.
42. Takeshi Nitta, Izumi Ohigashi, Yasushi Nakagawa and Yousuke Takahama :
Lympho-epithelial complexes in the thymic cortex,
第40回日本免疫学会学術集会, Nov. 2011.
43. Izumi Ohigashi and Yousuke Takahama :
Identification of the transgenic integration site in immunodeficient tgε26 human CD3ε transgenic mice,
第40回日本免疫学会学術集会, Nov. 2011.
44. Noriko Mizusawa, 友成 章, Chisato Kosugi, 小倉 真琴, Nagakatsu Harada, Izumi Ohigashi, Mitsuo Itakura and Katsuhiko Yoshimoto :
ヒトインスリン遺伝子のグルコ-ス応答性転写調節に及ぼすGG配列の役割,
第45回日本糖尿病学会年次学術総会, May 2002.
45. 山崎 弘幸, Noriko Mizusawa, Chisato Kosugi, Nagakatsu Harada, Izumi Ohigashi, 本田 壮一, Shozo Yamada, Toshiaki Sano, Teruyoshi Kageji, Shinji Nagahiro and Katsuhiko Yoshimoto :
GH下垂体腺腫におけるPRKAR1A遺伝子異常の解析,
第12回日本間脳下垂体腫瘍学会, Feb. 2002.
46. 本田 壮一, Chisato Kosugi, Shozo Yamada, 木村 敏彦, Nagakatsu Harada, Izumi Ohigashi, Noriko Mizusawa, 山崎 弘幸, Toshiaki Sano and Katsuhiko Yoshimoto :
下垂体腺腫における網膜芽細胞腫 (RB)遺伝子異常の解析,
第12回日本間脳下垂体腫瘍学会, Feb. 2002.
47. Noriko Mizusawa, 友成 章, Chisato Tanaka, Nagakatsu Harada, Izumi Ohigashi, Mitsuo Itakura and Katsuhiko Yoshimoto :
インスリン遺伝子のグルコース応答性転写調節に及ぼすCG配列の役割,
第24回日本分子生物学会年会, Dec. 2001.
48. Izumi Ohigashi, 長谷川 朋子, Nagakatsu Harada, Chisato Tanaka and Katsuhiko Yoshimoto :
DNAマイクロアレイを用いた膵島α細胞およびβ細胞に特異的に発現する遺伝子の検索,
第44回日本糖尿病学会年次学術総会, Apr. 2001.
49. Nagakatsu Harada, Izumi Ohigashi, Chisato Tanaka, Mitsuo Itakura and Katsuhiko Yoshimoto :
膵β細胞における発現プロファイルの解析および新規遺伝子のクローニング,
第44回日本糖尿病学会年次学術総会, Apr. 2001.
50. Chisato Tanaka, Nagakatsu Harada, Izumi Ohigashi, Mitsuo Itakura and Katsuhiko Yoshimoto :
グルカゴン遺伝子の転写調節に関わる新規蛋白の同定とその解析,
第44回日本糖尿病学会年次学術総会, Apr. 2001.
51. Izumi Ohigashi, Nagakatsu Harada, Chisato Tanaka and Katsuhiko Yoshimoto :
cyclin D1の異常は副甲状腺細胞の増殖とホルモン分泌異常を引き起こす,
第222回徳島医学会学術集会 (平成12年度冬期), Jan. 2001.

Et cetera, Workshop:

1. Sayumi Fujimori, Izumi Ohigashi, 高田 慎治 and Yousuke Takahama :
胸腺上皮細胞特異的なWnt/β-cateninシグナル経路活性制御の影響,
第18回 四国免疫フォーラム, Jun. 2019.
2. 村松 直美, Izumi Ohigashi and Yousuke Takahama :
CD8T細胞の正の選択におけるペプチドスイッチ仮説の検証,
第29回 Kyoto T cell conference, Jun. 2019.
3. Izumi Ohigashi and Yousuke Takahama :
胸腺上皮細胞のオミクスプロファイリング,
第29回 Kyoto T cell conference, Jun. 2019.
4. Khanom Shahina Umme, Kenta Kondou, Kensuke Takada, Izumi Ohigashi and Yousuke Takahama :
Peptide-induced positive selection of CD8+ T cells in vivo,
第17回 四国免疫フォーラム, Jun. 2018.
5. 近藤 博之, Yousuke Takahama and Izumi Ohigashi :
胸腺皮質上皮細胞で高発現する新規分子の機能解析,
第28回 Kyoto T cell Conference, Jun. 2018.
6. Naoko Matsui, Izumi Ohigashi, 山本 遥平, 中川 英刀, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第37回日本胸腺研究会, Feb. 2018.
7. Izumi Ohigashi and Yousuke Takahama :
T細胞の自己寛容性確立におけるCCL21の役割,
第37回 日本胸腺研究会, Feb. 2018.
8. 藤原 翔, 森 空悟, Izumi Ohigashi, Yousuke Takahama and 早坂 晴子 :
メラノーマ組織に形成される高内皮細静脈様血管の検出,
第26回がん転移学会学術集会・総会, Jul. 2017.
9. 近藤 博之, Izumi Ohigashi and Yousuke Takahama :
CCL21Ser欠損マウスにおけるT細胞異常,
第16回四国免疫フォーラム, Jun. 2017.
10. Izumi Ohigashi and Yousuke Takahama :
胸腺髄質上皮細胞の再生におけるβ5t陽性上皮前駆細胞の寄与,
第36回胸腺研究会, Feb. 2017.
11. Naoko Matsui, Izumi Ohigashi, 中川 英刀, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第36回日本胸腺研究会, Feb. 2017.
12. 香西 美奈, Izumi Ohigashi and Yousuke Takahama :
CCL21,
第15回四国免疫フォーラム, Jun. 2016.
13. Izumi Ohigashi and Yousuke Takahama :
髄質上皮細胞の維持と再生におけるb5t陽性前駆細胞の寄与,
第35回胸腺研究会, Feb. 2016.
14. Naoko Matsui, Izumi Ohigashi, Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた胸腺上皮細胞の解析,
第35回日本胸腺研究会, 39, Feb. 2016.
15. 近藤 博之, Izumi Ohigashi and Yousuke Takahama :
胸腺皮質上皮細胞で高発現される機能未知新規遺伝子の研究,
2015感染免疫クラスター・ミニリトリート, Nov. 2015.
16. Myn Uddin, Izumi Ohigashi and Yousuke Takahama :
Seeking transcriptional mechanisms for regulation of b5t expression,
第14回 四国免疫フォーラム, Jun. 2015.
17. Naoko Matsui, Izumi Ohigashi, Yasushi Nakagawa, Kazuya Kondo and Yousuke Takahama :
ヒト胸腺を用いた単一細胞解析への試み,
第34回日本胸腺研究会, Feb. 2015.
18. Uddin Md.Myn, Izumi Ohigashi and Yousuke Takahama :
Seeking transcriptional mechanisms for regulation of 5t expression,
2014感染免疫クラスター・ミニリトリート, Oct. 2014.
19. 近藤 博之, Izumi Ohigashi and Yousuke Takahama :
胸腺皮質上皮細胞で高発現される機能未知新規遺伝子の研究:ノックアウトマウスと特異的抗体の作製によるアプローチ,
2014感染免疫クラスター・ミニリトリート, Oct. 2014.
20. 香西 美奈, Izumi Ohigashi and Yousuke Takahama :
CCL21Ser欠損マウスにおける免疫システムの解析,
2013感染免疫クラスター・ミニリトリート, Oct. 2013.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 胸腺上皮細胞分岐分子メカニズムの研究 (Project/Area Number: 17K08884 )
  • 胸腺における「正の選択」の本質を問う (Project/Area Number: 16H02630 )
  • Molecular mechanism of the development of thymic epithelial cells (Project/Area Number: 15K19130 )
  • Development and developmental potential of beta5t-expressing thymic epithelial cells (Project/Area Number: 25860361 )
  • The challenge for the development of therapy for autoimmune disorder by the establishment of artificial thymic medullary organ (Project/Area Number: 23659241 )
  • Molecular basis for the thymic microenvironments that characterize the immune system (Project/Area Number: 23249025 )
  • Search by Researcher Number (00596588)