Tokushima University / Educator and Researcher Directory --- Fujiwara, Natsumi

Personal Web Page

https://researchmap.jp/natsumi-fujiwara (researchmap)

https://orcid.org/0000-0002-9020-9478 (ORCID)

Field of Study

○	Periodontology, Oral Microbiology

Subject of Study

○	新規化合物の口腔細菌に与える影響, 口腔細菌と緑膿菌がもたらす誤嚥性肺炎の重篤化機構の解明, 口腔保健学科生における歯科衛生士臨床実習効果

Book / Paper

Book:

1.	Atsue Matsumoto, Akiko Iwamoto, Yuko Omae, Atsushi Shimazu, Hideaki Amano, Natsumi Fujiwara, Toshihiko Tsuka, Nana Ashikaga, Saori Kawano, Yukina Moriyama, Kanako Matsuzoe, Ayumi Ouchi, Shiori Miyasako, Saki Okita, Nao muroi, Mao Muroi, Erusu Nin, Toshinori Ando, Tetsuya Yoshimoto, Satoko Otani, Yuko Iwamoto, Noriko Kodama, Noriko Kadomoto, Katsuyuki Kozai, Hidenori Nishimura and Takashi Takata : Dental Service Activity Report in Cambodia Elementary School, 広島大学歯学会, Hiroshima, Jun. 2011.

Academic Paper (Judged Full Paper):

1.	Yamashita Syohei, Okamoto Motoki, Mendonca Melanie, Natsumi Fujiwara, Kitamura Eiko, Chang Sam Chang-Sheng, Brueckner Susanne, Shindo Satoru, Kuriki Nanako, Cooley A Marion, Dhillon Gill Navi, Kawai Toshihisa, Bartlett D. John, Everett T. Eric and Suzuki Maiko : Fluoride Alters Gene Expression via Histone H3K27 Acetylation in Ameloblast-like LS8 Cells, International Journal of Molecular Sciences, Vol.25, No.17, 2024.
2.	Shengjian Jin, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Hiroko Hagita, Motoharu Sarubo, Natsumi Fujiwara, Qi Guangying, Naozumi Ishimaru and Yasusei Kudo : Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma., Cancer Medicine, Vol.12, No.24, 22156-22169, 2023. (Summary) This study highlights the critical role of OTUB1 in HNSCC progression via modulating YAP1. Targeting the OTUB1-YAP1 axis holds promise as a potential therapeutic strategy for HNSCC treatment. (Keyword) deubiquitinating enzyme (DUB) / head and neck squamous cell carcinoma / invasion / OTUB1 / YAP (Tokushima University Institutional Repository) ● Metadata: 118778 (Link to Publication Site) ● Publication site (DOI): 10.1002/cam4.6735 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37986681 ● CiNii @ National Institute of Informatics (CRID): 1940583859514191616 ● Summary page in Scopus @ Elsevier: 2-s2.0-85177448617 (Tokushima University Institutional Repository: 118778, DOI: 10.1002/cam4.6735, PubMed: 37986681, CiNii: 1940583859514191616, Elsevier: Scopus)
3.	Kayo Yoshida, Kaya Yoshida, Mariko Seyama, Yuka Hiroshima, Mana Mekata, Natsumi Fujiwara, Yasusei Kudo and Kazumi Ozaki : Porphyromonas gingivalis outer membrane vesicles in cerebral ventricles activate microglia in mice, Oral Diseases, Vol.29, No.8, 3688-3697, 2023. (Summary) Objective: Porphyromonas gingivalis (Pg) is thought to be involved in the progression of Alzheimer's disease (AD). Whether Pg or its contents can reach the brain and directly affect neuropathology is, however, unknown. Here, we investigated whether outer membrane vesicles (OMVs) of Pg translocate to the brain and induce the pathogenic features of AD. Material and Methods: Pg OMVs were injected into the abdominal cavity of mice for 12 weeks. Pg OMV translocation to the brain was detected by immunohistochemistry using an anti-gingipain antibody. Tau protein and microglial activation in the mouse brain were examined by western blotting and immunohistochemistry. The effect of gingipains on inflammation was assessed by real-time polymerase chain reaction using human microglial HMC3 cells. Results: Gingipains were detected in the region around cerebral ventricles, choroid plexus, and ventricular ependymal cells in Pg OMV-administered mice. Tau and phosphorylated Tau protein increased and microglia were activated. Pg OMVs also increased the gene expression of proinflammatory cytokines in HMC3 cells in a gingipain-dependent manner. Conclusion: Pg OMVs, including gingipains, can reach the cerebral ventricle and induce neuroinflammation by activating microglia. Pg OMVs may provide a better understanding of the implications of periodontal diseases in neurodegenerative conditions such as AD. (Keyword) cerebral ventricle / gingipain / microglia / neuroinflammation / outer membrane vesicle / Porphyromonas gingivalis (Tokushima University Institutional Repository) ● Metadata: 118518 (Link to Publication Site) ● Publication site (DOI): 10.1111/odi.14413 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36266256 ● CiNii @ National Institute of Informatics (CRID): 1360580229799895936 ● Summary page in Scopus @ Elsevier: 2-s2.0-85141542224 (Tokushima University Institutional Repository: 118518, DOI: 10.1111/odi.14413, PubMed: 36266256, CiNii: 1360580229799895936, Elsevier: Scopus)
4.	Natsumi Fujiwara, Shohei Yamashita, Motoki Okamoto, A Marion Cooley, Kazumi Ozaki, T Eric Everett and Maiko Suzuki : Perfluorooctanoic acid-induced cell death via the dual roles of ROS-MAPK/ERK signaling in ameloblast-lineage cells., Ecotoxicology and Environmental Safety, Vol.260, 2023. (Summary) Perfluorooctanoic acid (PFOA) is an artificial fluorinated organic compound that has generated increased public attention due to its potential health hazards. Unsafe levels of PFOA exposure can affect reproduction, growth and development. During tooth enamel development (amelogenesis), environmental factors including fluoride can cause enamel hypoplasia. However, the effects of PFOA on ameloblasts and tooth enamel formation remain largely unknown. In the present study we demonstrate several PFOA-mediated cell death pathways (necrosis/necroptosis, and apoptosis) and assess the roles of ROS-MAPK/ERK signaling in PFOA-mediated cell death in mouse ameloblast-lineage cells (ALC). ALC cells were treated with PFOA. Cell proliferation and viability were analyzed by MTT assays and colony formation assays, respectively. PFOA suppressed cell proliferation and viability in a dose dependent manner. PFOA induced both necrosis (PI-positive cells) and apoptosis (cleaved-caspase-3, γH2AX and TUNEL-positive cells). PFOA significantly increased ROS production and up-regulated phosphor-(p)-ERK. Addition of ROS inhibitor N-acetyl cysteine (NAC) suppressed p-ERK and decreased necrosis, and increased cell viability compared to PFOA alone, whereas NAC did not change apoptosis. This suggests that PFOA-mediated necrosis was induced by ROS-MAPK/ERK signaling, but apoptosis was not associated with ROS. Addition of MAPK/ERK inhibitor PD98059 suppressed necrosis and increased cell viability compared to PFOA alone. Intriguingly, PD98059 augmented PFOA-mediated apoptosis. This suggests that p-ERK promoted necrosis but suppressed apoptosis. Addition of the necroptosis inhibitor Necrostatin-1 restored cell viability compared to PFOA alone, while pan-caspase inhibitor Z-VAD did not mitigate PFOA-mediated cell death. These results suggest that 1) PFOA-mediated cell death was mainly caused by necrosis/necroptosis by ROS-MAPK/ERK signaling rather than apoptosis, 2) MAPK/ERK signaling plays the dual roles (promoting necrosis and suppressing apoptosis) under PFOA treatment. This is the initial report to indicate that PFOA could be considered as a possible causative factor for cryptogenic enamel malformation. Further studies are required to elucidate the mechanisms of PFOA-mediated adverse effects on amelogenesis. (Keyword) Mice / Animals / Reactive Oxygen Species / Ameloblasts / Cell Death / Necrosis (Tokushima University Institutional Repository) ● Metadata: 118930 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ecoenv.2023.115089 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37271104 ● Search Scopus @ Elsevier (PMID): 37271104 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ecoenv.2023.115089 (Tokushima University Institutional Repository: 118930, DOI: 10.1016/j.ecoenv.2023.115089, PubMed: 37271104)
5.	Natsumi Fujiwara, Mariko Seyama, Kayo Yoshida and Kazumi Ozaki : Oral exercise program to influence oral functions, health and oral literacy in the independent elderly., The Journal of Japan Society for Dental Hygiene, Vol.17, No.2, 49-59, 2023. (Keyword) 口腔体操 / 口腔機能 / 質問紙調査 / 行動変容 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520013962702282112 (CiNii: 1520013962702282112)
6.	Wenhua Shao, Takaaki Tsunematsu, Masaaki Umeda, Hiroaki Tawara, Natsumi Fujiwara, Yasuhiro Mouri, Rieko Arakaki, Naozumi Ishimaru and Yasusei Kudo : Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma., Cancer Medicine, Vol.12, No.7, 8510-8525, 2023. (Summary) It recently has been reported that partial-epithelial-mesenchymal transition (p-EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). We previously have identified POSTN (which encodes periostin) as an invasion-promoting molecule in HNSCC. Interestingly, POSTN expression is frequently observed in cancer cells with higher p-EMT score by using a previous single-cell transcriptomic data of HNSCC cases. Although it is known that POSTN has 11 splicing variants, the role of them has not been determined in HNSCC. Here, we found that HNSCC cells with EMT features expressed POSTN isoforms, Iso3 (lacking exon 17 and 21) and Iso5 (lacking exon 17), whereas fibroblast expressed Iso3 and Iso4 (lacking exon 17, 18, and 21). The expression of POSTN Iso3 and Iso4 are known to be widely observed in various cell types including stromal cells. Therefore, we focused on the role of novel cancer cell-derived POSTN isoform, Iso5, in HNSCC. Single overexpression of POSTN Iso5 as well as Iso3 promoted invasion. Surprisingly, Iso5 synergistically promoted invasion together with Iso3. Notably, Iso5 as well as Iso3 upregulated p-EMT-related genes. We suggest that a novel cancer-specific POSTN isoform lacking exon 17 (Iso5) can be a useful marker for detecting cancer cells undergoing p-EMT. Moreover, a POSTN Iso5 can be a novel target for diagnosis and therapy in HNSCC. (Tokushima University Institutional Repository) ● Metadata: 118312 (Link to Publication Site) ● Publication site (DOI): 10.1002/cam4.5601 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36691359 ● Search Scopus @ Elsevier (PMID): 36691359 ● Search Scopus @ Elsevier (DOI): 10.1002/cam4.5601 (Tokushima University Institutional Repository: 118312, DOI: 10.1002/cam4.5601, PubMed: 36691359)
7.	Yoshida Kayo, Kaya Yoshida, Natsumi Fujiwara, Mariko Seyama, Ono Kisho, Kawai Hotaka, Guo Jiajie, Wang Ziyi, Weng Yao, Yu Yaqiong, Uchida-Fukuhara Yoko, Ikegame Mika, Sasaki Akira, Nagatsuka Hitoshi, Kamioka Hiroshi, Hirohiko Okamura and Kazumi Ozaki : Extracellular vesicles of P. gingivalis-infected macrophages induce lung injury, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1867, No.11, 166236, 2021. (Summary) Periodontal diseases are common inflammatory diseases that are induced by infection with periodontal bacteria such as Porphyromonas gingivalis (Pg). The association between periodontal diseases and many types of systemic diseases has been demonstrated; the term "periodontal medicine" is used to describe how periodontal infection/inflammation may impact extraoral health. However, the molecular mechanisms by which the factors produced in the oral cavity reach multiple distant organs and impact general health have not been elucidated. Extracellular vesicles (EVs) are nano-sized spherical structures secreted by various types of cells into the tissue microenvironment, and influence pathophysiological conditions by delivering their cargo. However, a detailed understanding of the effect of EVs on periodontal medicine is lacking. In this study, we investigated whether EVs derived from Pg-infected macrophages reach distant organs in mice and influence the pathophysiological status. EVs were isolated from human macrophages, THP-1 cells, infected with Pg. We observed that EVs from Pg-infected THP-1 cells (Pg-inf EVs) contained abundant core histone proteins such as histone H3 and translocated to the lungs, liver, and kidneys of mice. Pg-inf EVs also induced pulmonary injury, including edema, vascular congestion, inflammation, and collagen deposition causing alveoli destruction. The Pg-inf EVs or the recombinant histone H3 activated the NF-κB pathway, leading to increase in the levels of pro-inflammatory cytokines in human lung epithelial A549 cells. Our results suggest a possible mechanism by which EVs produced in periodontal diseases contribute to the progression of periodontal medicine. (Tokushima University Institutional Repository) ● Metadata: 116182 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbadis.2021.166236 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34389473 ● Search Scopus @ Elsevier (PMID): 34389473 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbadis.2021.166236 (Tokushima University Institutional Repository: 116182, DOI: 10.1016/j.bbadis.2021.166236, PubMed: 34389473)
8.	Wenhua Shao, Natsumi Fujiwara, Yasuhiro Mouri, Satoru Kisoda, Kayo Yoshida, Kaya Yoshida, Hiromichi Yumoto, Kazumi Ozaki, Naozumi Ishimaru and Yasusei Kudo : Conversion from epithelial to partial-EMT phenotype by Fusobacterium nucleatum infection promotes invasion of oral cancer cells., Scientific Reports, Vol.11, No.1, 14943, 2021. (Summary) The ability of cancer cells to undergo partial-epithelial mesenchymal transition (p-EMT), rather than complete EMT, poses a higher metastatic risk. Although Fusobacterium nucleatum mainly inhabits in oral cavity, attention has been focused on the F. nucleatum involvement in colorectal cancer development. Here we examined the p-EMT regulation by F. nucleatum in oral squamous cell carcinoma (OSCC) cells. We cultured OSCC cells with epithelial, p-EMT or EMT phenotype with live or heat-inactivated F. nucleatum. Expression of the genes involved in epithelial differentiation, p-EMT and EMT were examined in OSCC cells after co-culture with F. nucleatum by qPCR. Cell growth and invasion of OSCC cells were also examined. Both live and heat-inactivated F. nucleatum upregulated the expression of p-EMT-related genes in OSCC cells with epithelial phenotype, but not with p-EMT or EMT phenotype. Moreover, F. nucleatum promoted invasion of OSCC cells with epithelial phenotype. Co-culture with other strains of bacteria other than Porphyromonas gingivalis did not alter p-EMT-related genes in OSCC cells with epithelial phenotype. F. nucleatum infection may convert epithelial to p-EMT phenotype via altering gene expression in OSCC. Oral hygiene managements against F. nucleatum infection may contribute to reduce the risk for an increase in metastatic ability of OSCC. (Tokushima University Institutional Repository) ● Metadata: 116445 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-021-94384-1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34294795 ● Summary page in Scopus @ Elsevier: 2-s2.0-85111135598 (Tokushima University Institutional Repository: 116445, DOI: 10.1038/s41598-021-94384-1, PubMed: 34294795, Elsevier: Scopus)
9.	Natsumi Fujiwara, 久野恵, 田村真里奈, 篠永晴美, 迎美榛, Harumi Sakamoto, Mariko Seyama, Kazumi Ozaki and Daisuke Hinode : 歯科衛生士学生における摂食嚥下リハビリテーション臨床実習の有効性, The Journal of Japan Society for Dental Hygiene, Vol.15, No.2, 29-37, 2021. (Keyword) 歯科衛生士学生 / 臨床実習 / 摂食嚥下リハビリテーション / 多職種連携 / 専門性 / シカエイセイシガクセイ / リンショウジッシュウ / セッショクエンカリハビリテーション / タショクシュレンケイ / センモンセイ (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520854806140649088 (CiNii: 1520854806140649088)
10.	Natsumi Fujiwara, Naoya Kitamura, Kaya Yoshida, Tetsuya Yamamoto, Kazumi Ozaki and Yasusei Kudo : Involvement of Fusobacterium Species in Oral Cancer Progression: A Literature Review Including Other Types of Cancer, International Journal of Molecular Sciences, Vol.21, No.17, 6207, 2020. (Summary) Chronic inflammation caused by infections has been suggested to be one of the most important cause of cancers. It has recently been shown that there is correlation between intestinal bacteria and cancer development including metastasis. As over 700 bacterial species exist in an oral cavity, it has been concerning that bacterial infection may cause oral cancer. However, the role of bacteria regarding tumorigenesis of oral cancer remains unclear. Several papers have shown that species deriving the oral cavities, especially, play a crucial role for the development of colorectal and esophageal cancer. is a well-known oral bacterium involved in formation of typical dental plaque on human teeth and causing periodontal diseases. The greatest characteristic of is its ability to adhere to various bacteria and host cells. Interestingly, is frequently detected in oral cancer tissues. Moreover, detection of is correlated with the clinical stage of oral cancer. Although the detailed mechanism is still unclear, species have been suggested to be associated with cell adhesion, tumorigenesis, epithelial-to-mesenchymal transition, inflammasomes, cell cycle, etc. in oral cancer. In this review, we introduce the reports focused on the association of species with cancer development and progression including oral, esophageal, and colon cancers. (Keyword) Cell Adhesion / Colonic Neoplasms / Disease Progression / Epithelial-Mesenchymal Transition / Esophageal Neoplasms / Fusobacterium / Fusobacterium Infections / Humans / Inflammasomes / Mouth / Mouth Neoplasms (Tokushima University Institutional Repository) ● Metadata: 115246 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijms21176207 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32867334 ● Summary page in Scopus @ Elsevier: 2-s2.0-85090108629 (Tokushima University Institutional Repository: 115246, DOI: 10.3390/ijms21176207, PubMed: 32867334, Elsevier: Scopus)
11.	Natsumi Fujiwara, Keiji Murakami, Kaya Yoshida, Shunsuke Sakurai, Yasusei Kudo, Kazumi Ozaki, Katsuhiko Hirota, Hideki Fujii, Maiko Suzuki, Yoichiro Miyake and Hiromichi Yumoto : Suppresive effects of 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymer on the adherence of Candida species and MRSA to acrylic denture resin., Heliyon, Vol.6, e04211, 2020. (Tokushima University Institutional Repository) ● Metadata: 115916 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.heliyon.2020.e04211 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32577575 ● Summary page in Scopus @ Elsevier: 2-s2.0-85086425832 (Tokushima University Institutional Repository: 115916, DOI: 10.1016/j.heliyon.2020.e04211, PubMed: 32577575, Elsevier: Scopus)
12.	Satoru Kisoda, Wenhua Shao, Natsumi Fujiwara, Yasuhiro Mouri, Takaaki Tsunematsu, Shengjian Jin, Rieko Arakaki, Naozumi Ishimaru and Yasusei Kudo : Prognostic value of partial EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis., Oral Diseases, Vol.26, No.6, 1149-1156, 2020. (Summary) Our findings suggest that p-EMT program may be involved in poor prognosis of HNSCC. SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 can be used for a prognostic marker. Moreover, HNSCC cells with p-EMT phenotype can be a useful model for investigating a nature of p-EMT. (Tokushima University Institutional Repository) ● Metadata: 114969 (Link to Publication Site) ● Publication site (DOI): 10.1111/odi.13351 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32277532 ● Summary page in Scopus @ Elsevier: 2-s2.0-85083974773 (Tokushima University Institutional Repository: 114969, DOI: 10.1111/odi.13351, PubMed: 32277532, Elsevier: Scopus)
13.	Mariko Seyama, Kaya Yoshida, Kayo Yoshida, Natsumi Fujiwara, Kisho Ono, Takanori Eguchi, Hotaka Kawai, Jiajie Guo, Yao Weng, Yuan Haoze, Kenta Uchibe, Mika Ikegame, Akira Sasaki, Hitoshi Nagatsuka, Kuniaki Okamoto, Hirohiko Okamura and Kazumi Ozaki : Outer membrane vesicles of Porphyromonas gingivalis attenuate insulin sensitivity by delivering gingipains to the liver, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1866, No.6, 165731, 2020. (Summary) Outer membrane vesicles (OMVs) are nanosized particles derived from the outer membrane of gram-negative bacteria. Oral bacterium Porphyromonas gingivalis (Pg) is known to be a major pathogen of periodontitis that contributes to the progression of periodontal disease by releasing OMVs. The effect of Pg OMVs on systemic diseases is still unknown. To verify whether Pg OMVs affect the progress of diabetes mellitus, we analyzed the cargo proteins of vesicles and evaluated their effect on hepatic glucose metabolism. Here, we show that Pg OMVs were equipped with Pg-derived proteases gingipains and translocated to the liver in mice. In these mice, the hepatic glycogen synthesis in response to insulin was decreased, and thus high blood glucose levels were maintained. Pg OMVs also attenuated the insulin-induced Akt/ glycogen synthase kinase-3 (GSK-3 signaling in a gingipain-dependent fashion in hepatic HepG2 cells. These results suggest that the delivery of gingipains mediated by Pg OMV elicits changes in glucose metabolisms in the liver and contributes to the progression of diabetes mellitus. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbadis.2020.165731 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32088316 ● Search Scopus @ Elsevier (PMID): 32088316 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbadis.2020.165731 (DOI: 10.1016/j.bbadis.2020.165731, PubMed: 32088316)
14.	Natsumi Fujiwara, Hiromichi Yumoto, Koji Miyamoto, Katsuhiko Hirota, Hiromi Nakae, Saya Tanaka, Keiji Murakami, Yasusei Kudo, Kazumi Ozaki and Yoichiro Miyake : 2-Methacryloyloxyethyl phosphorylcholine (MPC)-polymer suppresses an increase of oral bacteria: a single-blind, crossover clinical trial, Clinical Oral Investigations, Vol.23, 739-746, 2019. (Summary) The biocompatible 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymers, which mimic a biomembrane, reduce protein adsorption and bacterial adhesion and inhibit cell attachment. The aim of this study is to clarify whether MPC-polymer can suppress the bacterial adherence in oral cavity by a crossover design. We also investigated the number of Fusobacterium nucleatum, which is the key bacterium forming dental plaque, in clinical samples. This study was a randomized, placebo-controlled, single-blind, crossover study, with two treatment periods separated by a 2-week washout period. We conducted clinical trial with 20 healthy subjects to evaluate the effect of 5% MPC-polymer mouthwash after 5 h on oral microflora. PBS was used as a control. The bacterial number in the gargling sample before and after intervention was counted by an electronic bacterial counter and a culture method. DNA amounts of total bacteria and F. nucleatum were examined by q-PCR. The numbers of total bacteria and oral streptcocci after 5 h of 5% MPC-polymer treatment significantly decreased, compared to the control group. Moreover, the DNA amounts of total bacteria and F. nucleatum significantly decreased by 5% MPC-polymer mouthwash. We suggest that MPC-polymer coating in the oral cavity may suppress the oral bacterial adherence. MPC-polymer can be a potent compound for the control of oral microflora to prevent oral infection. (Keyword) 2-Methacryloyloxyethylphosphorylcholine / Clinical study / Oral infection / Oral bacteria / Fusobacterium nucleatum (Tokushima University Institutional Repository) ● Metadata: 113011 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00784-018-2490-2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29766378 ● Summary page in Scopus @ Elsevier: 2-s2.0-85046904798 (Tokushima University Institutional Repository: 113011, DOI: 10.1007/s00784-018-2490-2, PubMed: 29766378, Elsevier: Scopus)
15.	Hidesuke Tada, Natsumi Fujiwara, Takaaki Tsunematsu, Yoshiko Tada, Rieko Arakaki, Naofumi Tamaki, Naozumi Ishimaru and Yasusei Kudo : Preventive effects of mouthguard use while sleeping on recurrent aphthous stomatitis: Preliminary interventional study., Clinical and Experimental Dental Research, Vol.3, No.5, 198-203, 2017. (Summary) Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulceration in the oral mucosa of otherwise healthy individuals and is often accompanied by severe pain. However, the etiology of RAS is not completely understood, and currently, no therapy can completely prevent RAS recurrence. In our clinical experience, we noticed that patients using a night guard, which is often used for bruxism treatment, did not develop RAS. Therefore, the aim of this study was to determine whether mouthguard use can suppress RAS development. The cohort of this interventional, prospective, single-center, and self-controlled study included 20 subjects who developed RAS at least once a month. The oral health of all the subjects was recorded for 60 days before and after intervention with a mouthguard. The average number of RAS incidences decreased from 5.5 to 1.0, the average days until healing decreased from 7.3 to 5.6, and the period with RAS decreased from 31.5 to 5.0 with mouthguard use. Mouthguard use may be beneficial for preventing RAS development. (Tokushima University Institutional Repository) ● Metadata: 111727 (Link to Publication Site) ● Publication site (DOI): 10.1002/cre2.88 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29744201 ● Search Scopus @ Elsevier (PMID): 29744201 ● Search Scopus @ Elsevier (DOI): 10.1002/cre2.88 (Tokushima University Institutional Repository: 111727, DOI: 10.1002/cre2.88, PubMed: 29744201)
16.	Sekita Yasuko, Keiji Murakami, Hiromichi Yumoto, Kouji Hirao, Takashi Amoh, Natsumi Fujiwara, Katsuhiko Hirota, Hideki Fujii, Takashi Matsuo, Yoichiro Miyake and Yoshiki Kashiwada : Antibiofilm and Anti-Inflammatory Activities of+ Houttuynia cordata Decoction for Oral Care, Evidence-Based Complementary and Alternative Medicine : eCAM, Vol.2017, 2850947, 2017. (Summary) Dental biofilms that form in the oral cavity play a critical role in the pathogenesis of several infectious oral diseases, including dental caries, periodontal disease, and oral candidiasis. (HC, Saururaceae) is a widely used traditional medicine, for both internal and external application. A decoction of dried HC leaves (dHC) has long been consumed as a health-promoting herbal tea in Japan. We have recently reported that a water solution of HC poultice ethanol extract (wHCP) exerts antimicrobial and antibiofilm effects against several important oral pathogens. It also exhibits anti-inflammatory effects on human keratinocytes. In our current study, we examined the effects of dHC on infectious oral pathogens and inflammation. Our results demonstrated that dHC exerts moderate antimicrobial effects against methicillin-resistant (MRSA) and other oral microorganisms. dHC also exhibited antibiofilm effects against MRSA, (involved in dental plaque formation), and and inhibitory effects on interleukin-8, CCL20, IP-10, and GRO productions by human oral keratinocytes stimulated by lipopolysaccharide (a cause of periodontal disease), without cytotoxic effects. This suggests that dHC exhibits multiple activities in microorganisms and host cells. dHC can be easily prepared and may be effective in preventing infectious oral diseases. (Tokushima University Institutional Repository) ● Metadata: 112956 (Link to Publication Site) ● Publication site (DOI): 10.1155/2017/2850947 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29234378 ● Summary page in Scopus @ Elsevier: 2-s2.0-85042323475 (Tokushima University Institutional Repository: 112956, DOI: 10.1155/2017/2850947, PubMed: 29234378, Elsevier: Scopus)
17.	Natsumi Fujiwara, Keiji Murakami, Michiyasu Nakao, Munehisa Toguchi, Hiromichi Yumoto, Katsuhiko Hirota, Takashi Matsuo, Shigeki Sano, Kazumi Ozaki and Yoichiro Miyake : Antibacterial and antibiofilm effects of Reuterin-Related Compounds to periodontopathic bacteria, Journal of Oral Health and Biosciences, Vol.30, No.1, 8-17, 2017. (Tokushima University Institutional Repository) ● Metadata: 111063 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.30.1_8 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.20738/johb.30.1_8 (Tokushima University Institutional Repository: 111063, DOI: 10.20738/johb.30.1_8)
18.	Natsumi Fujiwara, Keiji Murakami, Michiyasu Nakao, Munehisa Toguchi, Hiromichi Yumoto, Takashi Amoh, Katsuhiko Hirota, Takashi Matsuo, Shigeki Sano, Kazumi Ozaki and Yoichiro Miyake : Novel reuterin-related compounds suppress odour by periodontopathic bacteria, Oral Diseases, Vol.23, No.4, 492-497, 2017. (Summary) Halitosis is caused by volatile sulphur compounds including methyl mercaptan (CH3 SH) in the oral cavity and is a serious problem that limits interpersonal social communication. The aim of study was to evaluate the effects of reuterin-related compounds (RRCs) on halitosis-related periodontopathic bacteria in vitro. RRC-01, RRC-02 and RRC-03 (32 and 64 g ml(-1) ) in culture media containing Fusobacterium nucleatum JCM8523 and Porphyromonas gingivalis ATCC33277 were used. The effects of RRCs on CH3 SH production and detectable odour by F. nucleatum and P. gingivalis were examined by CH3 SH production assay and organoleptic test, respectively. The number of bacterial cells was also measured using an ATP assay. In P. gingivalis treated with RRCs, the expression of mgl gene, which is responsible for CH3 SH production, was examined by qRT-PCR. CH3 SH production and the score of detectable odour from F. nucleatum and P. gingivalis culture media containing RRCs were significantly lower than that without RRCs (P < 0.05). The expression of mgl gene in P. gingivalis was significantly downregulated by RRC-01 (P < 0.01), but not by RRC-02 or RRC-03. RRCs are potent oral care products for preventing halitosis via reducing CH3 SH production. (Link to Publication Site) ● Publication site (DOI): 10.1111/odi.12638 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28083982 ● Summary page in Scopus @ Elsevier: 2-s2.0-85015084211 (DOI: 10.1111/odi.12638, PubMed: 28083982, Elsevier: Scopus)
19.	Hiromi Nakae, Masami Yoshioka, 薮内さつき, Tokiko Doi, Natsumi Fujiwara, Hiroki Iga and Daisuke Hinode : 徳島県内の回復期病院における看護師の口腔ケアに対する認識ーアンケート調査結果からー, Journal of Shikoku Public Health Society, Vol.62, No.1, 95-99, 2017. (Keyword) 回復期病院 / 口腔ケア / アンケート調査 / 看護師
20.	Takamura Haruna, Kaya Yoshida, Hirohiko Okamura, Natsumi Fujiwara and Kazumi Ozaki : Porphyromonas gingivalis attenuates the insulin-induced phosphorylation and translocation of forkhead box protein O1 in human hepatocytes, Archives of Oral Biology, Vol.69, 19-24, 2016. (Tokushima University Institutional Repository) ● Metadata: 111993 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.archoralbio.2016.05.010 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84969142160 (Tokushima University Institutional Repository: 111993, DOI: 10.1016/j.archoralbio.2016.05.010, Elsevier: Scopus)
21.	Takaaki Tsunematsu, Natsumi Fujiwara, Maki Yoshida, Yukihiro Takayama, Satoko Kujiraoka, Guangying Qi, Masae Kitagawa, Tomoyuki Kondo, Akiko Yamada, Rieko Arakaki, Mutsumi Miyauchi, Ikuko Ogawa, Yoshihiro Abiko, Hiroki Nikawa, Shinya Murakami, Takashi Takata, Naozumi Ishimaru and Yasusei Kudo : Human odontogenic epithelial cells derived from epithelial rests of Malassez possess stem cell properties., Laboratory Investigation; a Journal of Technical Methods and Pathology, 2016. (Summary) Epithelial cell rests of Malassez (ERM) are quiescent epithelial remnants of the Hertwig's epithelial root sheath (HERS) that are involved in the formation of tooth roots. ERM cells are unique epithelial cells that remain in periodontal tissues throughout adult life. They have a functional role in the repair/regeneration of cement or enamel. Here, we isolated odontogenic epithelial cells from ERM in the periodontal ligament, and the cells were spontaneously immortalized. Immortalized odontogenic epithelial (iOdE) cells had the ability to form spheroids and expressed stem cell-related genes. Interestingly, iOdE cells underwent osteogenic differentiation, as demonstrated by the mineralization activity in vitro in mineralization-inducing media and formation of calcification foci in iOdE cells transplanted into immunocompromised mice. These findings suggest that a cell population with features similar to stem cells exists in ERM and that this cell population has a differentiation capacity for producing calcifications in a particular microenvironment. In summary, iOdE cells will provide a convenient cell source for tissue engineering and experimental models to investigate tooth growth, differentiation, and tumorigenesis.Laboratory Investigation advance online publication, 1 August 2016; doi:10.1038/labinvest.2016.85. (Tokushima University Institutional Repository) ● Metadata: 113576 (Link to Publication Site) ● Publication site (DOI): 10.1038/labinvest.2016.85 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27479086 ● Search Scopus @ Elsevier (PMID): 27479086 ● Search Scopus @ Elsevier (DOI): 10.1038/labinvest.2016.85 (Tokushima University Institutional Repository: 113576, DOI: 10.1038/labinvest.2016.85, PubMed: 27479086)
22.	Yasuko Sekita, Keiji Murakami, Hiromichi Yumoto, Takashi Amoh, Natsumi Fujiwara, Shohei Ogata, Takashi Matsuo, Yoichiro Miyake and Yoshiki Kashiwada : Preventive Effects of Houttuynia cordata Extract for Oral Infectious Diseases., BioMed Research International, Vol.2016, 2581876, 2016. (Summary) Houttuynia cordata (HC) (Saururaceae) has been used internally and externally as a traditional medicine and as an herbal tea for healthcare in Japan. Our recent survey showed that HC poultice (HCP) prepared from smothering fresh leaves of HC had been frequently used for the treatment of purulent skin diseases with high effectiveness. Our experimental study also demonstrated that ethanol extract of HCP (eHCP) has antibacterial, antibiofilm, and anti-inflammatory effects against S. aureus which caused purulent skin diseases. In this study, we focused on novel effects of HCP against oral infectious diseases, such as periodontal disease and dental caries. We determined the antimicrobial and antibiofilm effects of water solution of HCP ethanol extract (wHCP) against important oral pathogens and investigated its cytotoxicity and anti-inflammatory effects on human oral epithelial cells. wHCP had moderate antimicrobial effects against some oral microorganisms and profound antibiofilm effects against Fusobacterium nucleatum, Streptococcus mutans, and Candida albicans. In addition, wHCP had no cytotoxic effects and could inhibit interleukin-8 and CCL20 productions by Porphyromonas gingivalis lipopolysaccharide-stimulated human oral keratinocytes. Our findings suggested that wHCP may be clinically useful for preventing oral infectious diseases as a mouthwash for oral care. (Keyword) Anti-Bacterial Agents / bacteria / Biofilms / Cell Line / Cell Survival / Dental Caries / Houttuynia / Humans / Periodontal Diseases / Plant Extracts (Tokushima University Institutional Repository) ● Metadata: 112384 (Link to Publication Site) ● Publication site (DOI): 10.1155/2016/2581876 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27413739 ● Summary page in Scopus @ Elsevier: 2-s2.0-84978765486 (Tokushima University Institutional Repository: 112384, DOI: 10.1155/2016/2581876, PubMed: 27413739, Elsevier: Scopus)
23.	Hiromi Nakae, Masami Yoshioka, 薮内さつき, Tokiko Doi, Natsumi Fujiwara, Hiroki Iga and Daisuke Hinode : Problems on oral healthcare in convalescent hospitals : Questionnaire survey for non-dental professionals, Oral Care, Vol.11, No.1, 30-34, 2016. (Keyword) 口腔ケア / 回復期病院 / 多職種連携 / oral healthcare / convalescent hospitals / collaboration among multi-professions (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522825130978137600 (CiNii: 1522825130978137600)
24.	Mayumi Noguchi, Akira Tagaya, Ayako Sakoda, Hitoshi Komatsuzawa, Natsumi Fujiwara and Motoyuki Sugai : Effectiveness of Oral Health Education Program on Prevention of Periodontal Disease in Japanese Pregnant Women, Open Journal of Nursing, Vol.6, No.4, 282-293, 2016. (Keyword) periodontal disease / maintaining a pregnancy / oral health behaviors / Educational Intervention / Toothpick Brushing Method (Link to Publication Site) ● Publication site (DOI): 10.4236/ojn.2016.64029 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.4236/ojn.2016.64029 (DOI: 10.4236/ojn.2016.64029)
25.	Natsumi Fujiwara, Keiko Tsuruda, Yuko Iwamoto, Fuminori Kato, Teruko Odaki, Nobuko Yamane, Yuriko Hori, Yuka Harashima, Ayako Sakoda, Akira Tagaya, Hitoshi Komatsuzawa, Motoyuki Sugai and Mayumi Noguchi : Significant increase of oral bacteria in the early pregnancy period in Japanese women, Journal of Investigative and Clinical Dentistry, 2015. (Summary) Oral microflora during pregnancy is critical to oral health care in the mother and her child. We examined the changes in the oral microbiota between pregnancy and nonpregnancy periods. The study was performed using 132 healthy pregnant women enrolled from Hiroshima City Asa Citizens Hospital and 51 healthy nonpregnant women as control. During pregnancy, 132 subjects were assessed for seven microbial species by the cultured method and polymerase chain reaction at the early (7-16 weeks gestation), the middle (17-28 weeks), and the late (29-39 weeks) pregnancy periods. Pregnant women completed a series of questionnaires regarding oral and systemic health and lifestyle habits. The total cultivable microbial counts in the early pregnancy were significantly higher than that of the nonpregnant women (P < 0.05). The incidences of Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans in gingival sulcus during the early and middle pregnancy were significantly higher than the nonpregnant group (P < 0.05), while Prevotella intermedia and Fusobacterium nucleatum did not change. Candida species were more frequently detected during the middle and late pregnancy. The data suggest that pregnancy, especially in the early periods, promotes the proliferation of microorganisms in the oral cavity and facilitates a colonization of periodontal pathogens. (Link to Publication Site) ● Publication site (DOI): 10.1111/jicd.12189 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26345599 ● Summary page in Scopus @ Elsevier: 2-s2.0-85041927405 (DOI: 10.1111/jicd.12189, PubMed: 26345599, Elsevier: Scopus)
26.	Akiho MINATO, Kazumi Ozaki, Natsumi Fujiwara, Hiromi Nakae, Satsuki YABUUCHI and Miwa Matsuyama : Construction of test design for practical evaluation using OSCE method in the dental hygienist education, The Journal of Japan Society of Dental Hygiene Education, Vol.6, No.1, 30-39, 2015. (Keyword) 歯科衛生士教育 / 客観的臨床能力試験(OSCE) / 評価信頼性 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522543656015655552 (CiNii: 1522543656015655552)
27.	Natsumi Fujiwara, Shizuko Yanagisawa, Hiromi Nakae, Satsuki Yabuuchi, Yasuhiko Shirayama and Kazumi Ozaki : Qualitative analysis focused on the process of learning in clinical training for dental hygiene students, The Journal of Japan Society of Dental Hygiene Education, Vol.5, No.1, 39-45, 2014. (Keyword) 学習プロセス (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521136281135889280 (CiNii: 1521136281135889280)
28.	Hiromichi Yumoto, Katsuhiko Hirota, Kouji Hirao, Tsuyoshi Miyazaki, Nobuyuki Yamamoto, Koji Miyamoto, Keiji Murakami, Natsumi Fujiwara, Takashi Matsuo and Yoichiro Miyake : Anti-inflammatory and protective effects of 2-methacryloyloxyethyl phosphorylcholine polymer on oral epithelial cells., Journal of Biomedical Materials Research. Part A, Vol.103, No.2, 555-563, 2014. (Summary) Periodontitis is a chronic inflammatory disease initiated by a microbial biofilm formed in the periodontal pocket. Gingival epithelium plays important roles as the first physical barrier to bacterial invasion and in orchestrating the innate immune reaction via toll-like receptors (TLRs), which recognize various bacterial products, and maintaining its function. Newly developed oral care products to inhibit bacterial adherence, subsequent inflammatory reaction and protect the gingival epithelium are expected. We previously reported that 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymer coating decreased bacterial adhesion to human oral keratinocytes, RT-7, and mouth-rinsing with MPC-polymer inhibited the increase of oral bacteria. In this study, regarding the possibility of MPC-polymer application for preventing the adherence of periodontal pathogen, subsequent inflammatory reaction and protection of gingival epithelium, we examined the effects of MPC-polymer on the adherence of Porphyromonas gingivalis, major periodontitis-related pathogen, and TLR2 ligand to RT-7 and subsequent interleukin (IL)-8 production. MPC-polymer treatment significantly reduced P. gingivalis adherence by 44% and TLR2-mediated IL-8 production by blocking the binding of its specific-ligand in a concentration-dependent manner. Furthermore, MPC-polymer pretreatment protected RT-7 from injury by chemical irritants, cetylpyridinium chloride. These findings suggest that MPC-polymer is potentially useful for oral care to prevent oral infection and to maintain oral epithelial function. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2014. (Keyword) Anti-Inflammatory Agents / Bacteroidaceae Infections / Cell Line, Transformed / Epithelial Cells / Humans / Mouth / periodontitis / Phosphorylcholine / Polymethacrylic Acids / Porphyromonas gingivalis (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm.a.35201 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24753309 ● Summary page in Scopus @ Elsevier: 2-s2.0-84924401882 (DOI: 10.1002/jbm.a.35201, PubMed: 24753309, Elsevier: Scopus)
29.	Ishikawa Makoto, Kaya Yoshida, Hirohiko Okamura, Kazuhiko Ochiai, Takamura Haruna, Natsumi Fujiwara and Kazumi Ozaki : Oral porphyromonas gingivalis translocates to the liver and regulates hepatic glycogen synthesis through the Akt/GSK-3b signaling pathway, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1832, No.12, 2035-2043, 2013. (Summary) Periodontal diseases are common chronic inflammatory disorders that result in the destruction of tissues around teeth. Many clinical studies suggest that periodontal diseases are risk factors for insulin resistance and diabetic mellitus development. However, the molecular mechanisms by which periodontal diseases regulate the progress of diabetes mellitus remain unknown. In this study, we investigated whether Porphyromonas gingivalis (P.g.), a major pathogen of periodontal diseases, present in the oral cavity, moves to the liver and affects hepatic glycogen synthesis. SNAP26b-tagged P.g. (SNAP-P.g.) was introduced into the oral cavity to induce periodontal disease in 4-week old female Balb/c mice. SNAP-P.g. was detected in the liver extracted from SNAP-P.g.-treated mice using nested PCR analysis. High blood glucose levels tended to promote SNAP-P.g. translocation from the oral cavity to the liver in mice. Periodic acid-Schiff staining suggested that hepatic glycogen synthesis decreased in SNAP-P.g.-treated mice. SNAP-P.g. was also internalized into the human hepatoma cell line HepG2, and this attenuated the phosphorylation of insulin receptor substrate (IRS)-1, Akt and glycogen synthase kinase-3β induced by insulin. Insulin-induced glycogen synthesis was suppressed by SNAP-P.g. in HepG2 cells. Our results suggest that P.g. translocation from the oral cavity to the liver may contribute to the progress of diabetes mellitus by influencing hepatic glycogenesis. (Keyword) periodontal disease / diabetes mellitus / Porphyromonas gingivalis / Hepatic glycogenesis / SNAP26b (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bbadis.2013.07.012 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23899607 ● Search Scopus @ Elsevier (PMID): 23899607 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbadis.2013.07.012 (DOI: 10.1016/j.bbadis.2013.07.012, PubMed: 23899607)

Academic Paper (Unrefereed Paper):

1.	Natsumi Kakiuchi, Akiho Minato, Yui Okazawa, Akari Otsu, Natsumi Fujiwara, Daisuke Hinode and Hiroki Iga : A Report of Activity in a Short-term Study Abroad to Helsinki Metropolia University of Applied Sciences, Shikoku Dental Research, Vol.27, No.1, 49-53, 2014. (Tokushima University Institutional Repository) ● Metadata: 109854 (Tokushima University Institutional Repository: 109854)

Review, Commentary:

1.	Natsumi Fujiwara : 歯科衛生士の研究活動を推進しより高い専門性を持つーこれからの学術大会における専門領域別・研究集会開催のご案内ー, The Journal of Japan Society for Dental Hygiene, Vol.18, No.2, 67-69, Feb. 2024.
2.	Hiromichi Yumoto, Katsuhiko Hirota, Yoichiro Miyake, Keiji Murakami, Natsumi Fujiwara, 秋月皆人 and Hideki Fujii : ``撥菌''∼口腔バイオフィルム感染症予防への応用∼, The Journal of Educational Conference on All Japan Colleges of Dental Hygiene, Vol.10, No.25, 13-17, Mar. 2021. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521980706066501120 (CiNii: 1521980706066501120)
3.	Yasusei Kudo, Tada Hidesuke, Natsumi Fujiwara, Tada Yoshiko, Takaaki Tsunematsu, Yoichiro Miyake and Naozumi Ishimaru : Oral environment and cancer, Genes and Environment, Vol.38, No.13, Aug. 2016. (Summary) Cancer is now the leading cause of death in Japan. A rapid increase in cancer mortality is expected as Japan is facing a super-aged society. Many causes of cancer are known to be closely linked to life style factors, such as smoking, drinking, and diet. The oral environment is known to be involved in the pathogenesis and development of various diseases such as bronchitis, pneumonia, diabetes, heart disease, and dementia. Because the oral cavity acts as the bodily entrance for air and food, it is constantly exposed to foreign substances, including bacteria and viruses. A large number of bacteria are endemic to the oral cavity, and indigenous oral flora act to prevent the settlement of foreign bacteria. The oral environment is influenced by local factors, including dental plaque, tartar, teeth alignment, occlusion, an incompatible prosthesis, and bad lifestyle habits, and systemic factors, including smoking, consumption of alcohol, irregular lifestyle and eating habits, obesity, stress, hormones, and heredity. It has recently been revealed that the oral environment is associated with cancer. In particular, commensal bacteria in the oral cavity are involved in the development of cancer. Moreover, Candida, human papilloma virus and Epstein-Barr virus as well as commensal bacteria have been reported to be associated with the pathogenesis of cancer. In this review, we introduce recent findings of the correlation between the oral environment and cancer. (Keyword) cancer / Oral environment / bacteria / Candida / Human papilloma virus / Epstein-Barr virus (Tokushima University Institutional Repository) ● Metadata: 114519 (Link to Publication Site) ● Publication site (DOI): 10.1186/s41021-016-0042-z (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27482300 ● Search Scopus @ Elsevier (PMID): 27482300 ● Search Scopus @ Elsevier (DOI): 10.1186/s41021-016-0042-z (Tokushima University Institutional Repository: 114519, DOI: 10.1186/s41021-016-0042-z, PubMed: 27482300)

Proceeding of International Conference:

1.	Natsumi Fujiwara : Basic research towards achieving evidence-based oral hygiene practice, International Symposium of Dental Hygiene 2024, Jul. 2024.
2.	Hideyuki Takano, Makoto Fukui, Natsumi Fujiwara, Yukihiro Momota and Keiko Aota : The usefulness of non-face-to-face clinical practice using smart glasses in dental hygiene student education, The 3rd annual meeting of the International Society of Oral Care, Apr. 2023.
3.	Kaya Yoshida, Mariko Seyama, Natsumi Fujiwara, Hirohiko Okamura and Kazumi Ozaki : The effects of outer membrane vesicles delived from Porphyromonas gingivalis on hepatic glucose metabolisms., International Society for ExtracellularVesicles 2019 Annual Meeting, Kyoto, Apr. 2019.
4.	Natsumi Fujiwara, Hiromichi Yumoto, Keiji Murakami, Yasusei Kudo, Hiromi Nakae, Katsuhiko Hirota, Kazumi Ozaki and Yoichiro Miyake : 2-methacryloyloxyethyl-phosphorylcholine (MPC)-polymer suppresses the adherence of oral bacteria, 2018 IADR/PER General Session (ExCel London Convention Center, London, England) 25-28th July, 2018, Jul. 2018.
5.	Hiromichi Yumoto, Takashi Matsuo, Katsuhiko Hirota, Kouji Hirao, Miyazaki Tsuyoshi, Keiji Murakami, Natsumi Fujiwara and Yoichiro Miyake : Anti-inflammatory and protective effects of 2-methacryloyloxyethyl-phosphorylcholine-polymer on oral epithelial cells, 92th General Session & Exhibition of the International Association for Dental Research (Cape Town, South Africa), Jun. 2014.
6.	Kaya Yoshida, Haruna Takamura, Hirohiko Okamura, Natsumi Fujiwara and Kazumi Ozaki : Oral porphyromonas gingivalis translocates to liver and regulates hepatic glycogen metabolisms by attenuating insulin signaling, 10 th Asian Pacific Society of Periodontology Meeting, Nara, Japan, Sep. 2013.
7.	Daisuke Hinode and Natsumi Fujiwara : Tongue coating and oral malodor, Helsinki Metropolia University of Applied Sciences International Meeting, Helsinki, Finland, Mar. 2011.
8.	Yumi Hoshimo, Natsumi Fujiwara, Atsuko Nakamichi and Daisuke Hinode : Introduction of the clinical basic training using new teaching device and evaluation by OSCE for the dental hygienist education in The University of Tokushima, Helsinki Metropolia University of Applied Sciences International Meeting, Helsinki, Finland, Mar. 2011.

Proceeding of Domestic Conference:

1.	siqi chen, Natsumi Fujiwara, Yasuhiro Mouri and Yasusei Kudo : Oral cancer microenvironment for promoting the biofilm formation of Fusobacterium nucleatum, 第83回日本癌学会学術総会, Sep. 2024.
2.	関田泰子, Keiji Murakami, Takashi Amoh, Natsumi Fujiwara and Hiromichi Yumoto : 災害時におけるドクダミ茶の口腔ケアへの有効利用, 第20回日本医療マネジメント学会高知県支部学術集会, Aug. 2024.
3.	関田泰子, Keiji Murakami, Takashi Amoh, Natsumi Fujiwara and Hiromichi Yumoto : 南海トラフ地震直後の感染症予防のためのドクダミの有効利用の検討, 第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中四国支部学術大会, Oct. 2023.
4.	Jin Shengjian, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Noriko Mizusawa, Hagita Hiroko, Sarubo Motoharu, Yoshida Kayo, Kaya Yoshida, Natsumi Fujiwara, Kazumi Ozaki, Naozumi Ishimaru and Yasusei Kudo : The role of deubiquitinating enzyme, OTUB1 in head and neck squamous cell carcinoma (HNSCC) progression, 第82回日本癌学会学術集会, Sep. 2023.
5.	YOSHIDA Kayo, Kaya Yoshida, Mariko Seyama, MEKATA Mana, Natsumi Fujiwara, Noriko Mizusawa, Yasuhiro Mouri, Yasusei Kudo and Kazumi Ozaki : 歯周病原菌由来細胞外小胞を介した肺炎発症メカニズムの解明, 第66回春季日本歯周病学会学術大会, May 2023.
6.	Mariko Seyama, Natsumi Fujiwara, Ayu Takai, MEKATA Mana, YOSHIDA Kayo, Kaya Yoshida and Kazumi Ozaki : 認知・口腔機能管理のためのWebシステムの可用性に関する研究, 第66回春季日本歯周病学会学術大会, May 2023.
7.	Mariko Seyama, Natsumi Fujiwara, Ayu Takai, MEKATA Mana, YOSHIDA Kayo, Kaya Yoshida and Kazumi Ozaki : 認知機能評価Webシステムの有用性に関する研究, 第20回日本口腔ケア学会/第3回国際口腔ケア総会・学術大会, Apr. 2023.
8.	Jin Shengjian, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Noriko Mizusawa, Hiroko Hagita, YOSHIDA Kayo, Kaya Yoshida, Natsumi Fujiwara, Kazumi Ozaki, Naozumi Ishimaru and Yasusei Kudo : The role of Deubiquitinating enzyme, OTUB1 in head and neck squamous cell carcinoma (HNSCC) progression, 第61回四国歯学会, Mar. 2023.
9.	Wenhua Shao, Natsumi Fujiwara, Yasuhiro Mouri and Yasusei Kudo : フソバクテリウム・ヌクレアタム感染による上皮性からp-EMT表現型への変換は，口腔癌細胞の浸潤を促進する,, 第44回日本分子生物学会年会, Dec. 2021.
10.	Mariko Seyama, Kayo Yoshida, Natsumi Fujiwara and Kazumi Ozaki : ライブ配信による臨床系基礎実習に関する一考察, 四国歯学会第57回例会, Mar. 2021. (Keyword) オンライン授業 / 臨床系基礎実習
11.	Kayo Yoshida, Natsumi Fujiwara, Akari Watanabe, Miwa Matsuyama and Kazumi Ozaki : ヘッドマウントディスプレイのマイクロスコープへの応用に関する研究, 第10回日本歯科衛生教育学会総会・学術大会(福岡県福岡市), Dec. 2019.
12.	Kayo Yoshida, Kazumi Ozaki, 中野明加里, Natsumi Fujiwara, Yuko Takeuchi and Shizuko Yanagisawa : ミールラウンドの遠隔支援における一評価指標としての嚥下時産生音の可能性, 日本歯科衛生学会第14回学術大会(愛知県名古屋市), Sep. 2019.
13.	久野恵, Natsumi Fujiwara, 篠永晴美, 迎美榛, Harumi Sakamoto, 田村真里奈, Akari Watanabe, Miwa Matsuyama, Kazumi Ozaki and Daisuke Hinode : 摂食・嚥下リハビリテーション臨床実習における歯科衛生士学生の学びと教育的効果, 日本歯科衛生学会第14回学術大会(愛知県名古屋市), Sep. 2019.
14.	Natsumi Fujiwara, Kazumi Ozaki, Kayo Yoshida, Yuko Takeuchi and Shizuko Yanagisawa : 口腔体操プログラム実施が自立高齢者の口腔機能および口腔リテラシーに与える効果, 日本歯科衛生学会第14回学術大会(愛知県名古屋市), Sep. 2019.
15.	Kayo Yoshida, Natsumi Fujiwara, Yuko Takeuchi, Shizuko Yanagisawa and Kazumi Ozaki : 健口体操プログラムは自立高齢者の口腔セルフケア行動と口腔衛生に影響を与える, 第3回徳島県地域包括ケアシステム学会学術集会(徳島県徳島市), Aug. 2019.
16.	Natsumi Fujiwara, Kayo Yoshida, Yuko Takeuchi, Shizuko Yanagisawa and Kazumi Ozaki : 健口体操プログラムは自立高齢者の口腔機能向上に影響を与える, 第3回徳島県地域包括ケアシステム学会学術集会(徳島県徳島市), Aug. 2019.
17.	Kaya Yoshida, Kayo Yoshida, Natsumi Fujiwara, Kazumi Ozaki and Hirohiko Okamura : 感染マクロファージの膜小胞は歯周病関連疾患発症に関与するか?, 第38回分子病理学研究会淡路島シンポジウム, Jul. 2019.
18.	Natsumi Fujiwara : 撥菌効果を有するポリマーを用いた口腔疾患予防への応用について, 2018年度ダイバーシティ推進研究交流発表会及び情報交換会(グランドエクシブ鳴門ザ・ロッジ, 徳島県鳴門市), Feb. 2019.
19.	Kaya Yoshida, Mariko Seyama, Natsumi Fujiwara and Kazumi Ozaki : Porphyromonas gingivalis感染したマクロファージが由来の膜小胞が肝臓糖代謝に及ぼす影響, 第61回秋季日本歯周病学会学術大会 2018年10月26日(大阪市), Vol.60, 115, Oct. 2018.
20.	Kazumi Ozaki, 濵田邦美, 湯浅雅志 and Natsumi Fujiwara : 要援護者の個別課題を共有・管理するICTシステムの開発, Journal of the Japanese Association of Periodontology, Vol.60, 135, Oct. 2018. (Keyword) クラウド型Webアプリケーションシステム / 地域ケア会議 / タイムライン機能 / 医療・介護・福祉連携
21.	Kumiko Miura, Kazumi Ozaki, Shizuko Yanagisawa, Yasuhiko Shirayama and Natsumi Fujiwara : ICTを活用した歯科衛生士による要介護高齢者の口腔健康管理について, Journal of the Japanese Association of Periodontology, Vol.60, 135, Oct. 2018. (Keyword) 口腔健康管理 / クラウド型Webアプリケーションシステム / 医療・介護連携
22.	Kaya Yoshida, Natsumi Fujiwara, Kazumi Ozaki, 内部健太, 池亀美華 and Hirohiko Okamura : Porphyromonas gingivalis感染したマクロファージが産生する膜小胞が肝臓糖代謝に及ぼす影響, 第60回日本歯科基礎医学会学術大会 2018年9月5-7日(九州大学病院キャンパス百年講堂, 福岡市), Sep. 2018.
23.	Natsumi Fujiwara, Keiji Murakami, Kaya Yoshida, Yasusei Kudo, Katsuhiko Hirota, Kazumi Ozaki, Hideki Fujii and Hiromichi Yumoto : MPCポリマーコーティングによる義歯用レジンのカンジダ付着(撥菌)効果, 第60回日本歯科基礎医学会学術大会 2018年9月5-7日(九州大学病院キャンパス百年講堂, 福岡市), Sep. 2018.
24.	Kaya Yoshida, Natsumi Fujiwara, Kazumi Ozaki, 内部健太, 池亀美華 and Hirohiko Okamura : Extracellular vesicles from Porphyromonas gingivalis-infected macrophages include histone proteins and translocate to the liver, 第10回日本RNAi研究会・第5回日本細胞外小胞学会 (グランドプリンスホテル広島・広島市), Aug. 2018. (Keyword) osteoblast
25.	Mariko Seyama, Kaya Yoshida, Natsumi Fujiwara and Kazumi Ozaki : Porphyromonas gingivalisの分泌小胞は肝臓の糖代謝に影響を与える, 第61回日本歯周病学会学術大会, Vol.60, 128, Jun. 2018.
26.	Natsumi Fujiwara, Kazumi Ozaki, Shizuko Yanagisawa, Mariko Seyama, Yuki Matsumura, Rika Kawano and Yasuhiko Shirayama : 徳島県那賀町における口腔ケア実施の実態調査と支援職員への口腔ケア研修会の取り組み, 第67回日本口腔衛生学会・総会_平成30年5月18-20日_北海道札幌市, Vol.68, 165, May 2018.
27.	Natsumi Fujiwara, Hiromichi Yumoto, Katsuhiko Hirota, Keiji Murakami and Kazumi Ozaki : Suppression of oral bacteria by 2-methacryloyloxyethyl-phosphorylcholine-polymer, 第59回歯科基礎医学会学術大会プログラム・抄録集平成29年9月16-18日(松本歯科大学，長野県塩尻市), 341, Sep. 2017.
28.	Natsumi Fujiwara, Tokiko Doi, Hiromi Nakae, Yuka Sogawa, Masami Yoshioka, 高橋侑子, 幸江真杉, Kazumi Ozaki and Daisuke Hinode : 本学歯科衛生学生の病棟口腔ケア臨床実習の取り組みとその効果, 第14回日本口腔ケア学会総会・学術大会プログラム・抄録集, 208, Apr. 2017.
29.	Natsumi Fujiwara, Keiji Murakami, Hiromichi Yumoto, Katsuhiko Hirota and Yoichiro Miyake : 歯周病原菌に対する新規化合物の効果, 第69回日本細菌学会中国・四国支部総会平成28年10月15-16日香川県高松市かがわ国際会議場, 38, Oct. 2016.
30.	池田真己, 中上久美子, 三野聖子, 榎恵子, 一宮麗子, 井手口英章, Natsumi Fujiwara, Kazumi Ozaki and Takashi Iwata : スキルス・ラボを活用した歯科衛生士の教育効果, 日本歯科衛生教育学会, Vol.7, No.2, 197, Oct. 2016.
31.	Natsumi Fujiwara, Hiromi Nakae, Masami Yoshioka, Yuka Sogawa, 高橋侑子, 田口侑子, Akari Watanabe, Tokiko Doi, Kazumi Ozaki and Daisuke Hinode : 某大学における周術期口腔機能管理の臨床実習の取り組みとその効果, 日本歯科衛生学会第11回学術大会 2016年9/17日~19日広島県広島市広島国際会議場, Vol.11, No.1, 174, Sep. 2016.
32.	Natsumi Fujiwara, Keiji Murakami, Hiromichi Yumoto, Katsuhiko Hirota, Kazumi Ozaki and Yoichiro Miyake : Effects of novel compounds on periodontopathic bacteria, 第58回歯科基礎医学会学術大会北海道札幌市 2016年8月24-26日, Aug. 2016.
33.	Kaya Yoshida, Natsumi Fujiwara, Yuka Hiroshima, Kaori Abe, Jun-ichi Kido and Kazumi Ozaki : Porphyhepatic cellsromonas gingivalis inhibits insulin signaling by regulating SOCS3 and IRS-1 in, 第59回春季日本歯周病学会学術大会, May 2016.
34.	Hiromi Nakae, 薮内さつき, Natsumi Fujiwara, Shizuko Yanagisawa, Masami Yoshioka, Kaya Yoshida, Yuko Takeuchi, Akari Watanabe, Tokiko Doi, Miwa Matsuyama, Hiroki Iga, Kazumi Ozaki, Daisuke Hinode, Masanori Nakano and Yasuhiko Shirayama : 健口体操ポスターを活用した口腔機能向上の取り組み, 第13回日本口腔ケア学会総会・学術大会, Apr. 2016.
35.	Hiromi Nakae, Natsumi Fujiwara, Hiroki Iga, Masami Yoshioka and Daisuke Hinode : 全人的医療を支援する歯科衛生士教育としての病棟実習の取り組みとその効果, 第34回日本歯科医学教育学会総会および学術大会鹿児島市, Jul. 2015.
36.	薮内さつき, Hiromi Nakae, Daisuke Hinode, Hiroki Iga, Kazumi Ozaki, Yasuhiko Shirayama, Miwa Matsuyama, Masami Yoshioka, Shizuko Yanagisawa, Natsumi Fujiwara, Akari Watanabe, Tokiko Doi, Fumiaki Kawano and Katsuhiko Yoshimoto : 歯学部学生の情動知能に対する高齢者交流学習の効果, 第34回日本歯科医学教育学会総会および学術大会鹿児島市, Jul. 2015.
37.	Natsumi Fujiwara, Hiromi Nakae, 薮内さつき and Kazumi Ozaki : 歯科衛生士学生の自己教育力に関する実態について, The Journal of Japanese Dental Education Association, Jul. 2015.
38.	Hiromi Nakae, Masami Yoshioka, 薮内さつき, Tokiko Doi, Natsumi Fujiwara, Hiroki Iga and Daisuke Hinode : 回復期病院職員が抱える口腔ケアについての悩みー他職種へのアンケート調査よりー, 第12回日本口腔ケア学会総会・学術大会, Jun. 2015.
39.	薮内さつき, Hiromi Nakae, Daisuke Hinode, Yuko Takeuchi, Hiroki Iga, Kazumi Ozaki, Yasuhiko Shirayama, Miwa Matsuyama, Shizuko Yanagisawa, Masami Yoshioka, Kaya Yoshida, Natsumi Fujiwara, Akari Watanabe, Tokiko Doi, Masanori Nakano, Fumiaki Kawano and Katsuhiko Yoshimoto : 地域育成型歯学教育プログラムの評価(第2報)地域福祉体験学習における教育効果の変化, 平成26年度FD推進プログラム大学教育カンファレンスin徳島, 62-63, Dec. 2014.
40.	Yumi Hoshimo, 溝部潤子, 中道敦子, Akari Watanabe, Natsumi Fujiwara, Kazumi Ozaki, Daisuke Hinode, Hiroki Iga, 岩城重次 and 菅武雄 : 口腔ケアシミュレータを応用したリカレント教育の試み -学生実習との比較- ・北九州, 第33回日本歯科医学教育学会, Jul. 2014.
41.	薮内さつき, Hiromi Nakae, Daisuke Hinode, Hiroki Iga, Kazumi Ozaki, Yasuhiko Shirayama, Miwa Matsuyama, Shizuko Yanagisawa, Masami Yoshioka, Yumi Hoshimo, Natsumi Fujiwara, Akari Watanabe, Fumiaki Kawano and Katsuhiko Yoshimoto : 高齢者交流学習後の歯学部生の高齢者イメージの変化・北九州, The Journal of Japanese Dental Education Association, 105, Jul. 2014.
42.	Yumi Hoshimo, Atsuko Nakamichi, 管武雄, Akari Watanabe, Natsumi Fujiwara, Miwa Matsuyama, Kazumi Ozaki, 岩城重次, Daisuke Hinode and Hiroki Iga : 歯科衛生士学生を対象とした新しい口腔ケア教育の取り組み-口腔ケアシミュレータを応用したケア実習の効果-, 日本歯科衛生教育学会雑誌, Vol.14, No.2, 109, Dec. 2013. (Keyword) 歯科衛生士教育 / 口腔ケア / シミュレータ
43.	石川真琴, Kaya Yoshida, Natsumi Fujiwara, Yoshitaka Hosokawa, Ikuko Hosokawa and Kazumi Ozaki : 歯周病原性細菌Porphyromonas gingivalis感染が肝臓糖代謝に及ぼす影響, 日本歯科保存学雑誌, 155, Nov. 2012.
44.	Kazumi Ozaki, 那賀川明美, Masanori Nakano, Yasuhiko Shirayama, Miwa Matsuyama, Daisuke Hinode, Masaru Hada, Masami Yoshioka, Atsuko Nakamichi, Kaya Yoshida, Yuko Takeuchi, Yumi Hoshimo, Natsumi Fujiwara, Hiromi Nakae, 薮内さつき, Hiroki Iga, Fumiaki Kawano and Tetsuo Ichikawa : 社会福祉施設での訪問口腔ケアを支援する包括ケア型地域ICTシステムについて, 第22回日本歯科医学会総会プログラム・事前抄録集, 163, Nov. 2012.
45.	Natsumi Fujiwara, Yasuhiko Shirayama, Atsuko Nakamichi, Yumi Hoshimo and Kazumi Ozaki : The Qualitative Study on the Evaluation of Dental Hygiene Students' Growth by Clinical Training, The Journal of Japan Society of Dental Hygiene Education, Vol.3, No.1, 54, Nov. 2012. (Keyword) Dental Hygienist / Clinical Training / M-GTA
46.	薮内さつき, Hiromi Nakae, Daisuke Hinode, Yuko Takeuchi, Hiroki Iga, Kazumi Ozaki, Masaru Hada, Yasuhiko Shirayama, Miwa Matsuyama, Masami Yoshioka, Atsuko Nakamichi, Yumi Hoshimo, Natsumi Fujiwara, Masanori Nakano, Fumiaki Kawano and Katsuhiko Yoshimoto : 高齢社会を担う地域育成型歯学教育:専門教育終了時の授業アンケートから考察される教育効果, 第31回日本歯科医学教育学会総会および学術大会プログラム・抄録集, 124, Jul. 2012.
47.	Atsuko Nakamichi, Miwa Matsuyama, Masanori Nakano, Yumi Hoshimo and Natsumi Fujiwara : 一口量が咀嚼回数に及ぼす影響, 日本咀嚼学会雑誌第22回日本咀嚼学会抄録, Vol.21, No.2, 132-133, Oct. 2011. (Keyword) 咀嚼回数 / 単位重量あたり咀嚼回数 / ひとくち量 / 個別一口量
48.	Masami Yoshioka, Masaaki Yokoyama, 中江弘美, 一宮斉子, Harumi Sakamoto, 薫廣瀬, Yuka Sogawa, 幸江真杉, 武川香織, Natsumi Fujiwara, Atsuko Nakamichi and Daisuke Hinode : 急性期の脳卒中患者に対する専門的口腔ケアについてのアンケート, Journal of Dental Health, Vol.61, No.4, 460, Oct. 2011.
49.	Yumi Hoshimo, Atsuko Nakamichi, Natsumi Fujiwara, Masami Yoshioka and Daisuke Hinode : 歯科衛生士学生に対するプロービング用顎模型を応用した実習の教育効果について, The Journal of Japan Society for Dental Hygiene, Vol.6, No.1, 106, Sep. 2011.
50.	Kazumi Ozaki, Natsumi Fujiwara, 石川真琴, Ikuko Hosokawa, Yoshitaka Hosokawa and Hiromichi Yumoto : う蝕関連細菌の家族内伝播と生活習慣による影響に関する研究 ―兄弟姉妹間の差異について―, 134回日本歯科保存学会春季学術大会, Jun. 2011.
51.	Kazumi Ozaki, Natsumi Fujiwara, 石川真琴, 細川育子, Yoshitaka Hosokawa and Hiromichi Yumoto : う蝕関連細菌の家族内伝播と生活習慣による影響に関する研究 ―兄弟姉妹間の差異について―, 134回日本歯科保存学会春季学術大会, Jun. 2011.
52.	Kan Nagao, Natsumi Fujiwara, Tomoko Kimura, Akihiro Yasue, Masami Yoshioka, Yoichiro Miyake, Katsuhiko Yoshimoto and Tetsuo Ichikawa : 東京医科歯科大学の臨床実習視察報告, 四国歯学会第38回例会, Mar. 2011.
53.	薮内さつき, 中江弘美, Daisuke Hinode, Yuko Takeuchi, Hiroki Iga, Masanori Nakano, Hideo Yoshida, Masaru Hada, Kazumi Ozaki, Masami Yoshioka, Kaya Yoshida, Atsuko Nakamichi, Yumi Hoshimo, Natsumi Fujiwara, Fumiaki Kawano and Katsuhiko Yoshimoto : 徳島大学教育GP「高齢社会を担う地域育成型歯学教育」授業アンケートから考察される教育効果, 平成22年度全学FD大学教育カンファレンス in 徳島, Jan. 2011.

Et cetera, Workshop:

1.	Natsumi Fujiwara, Wenhua Shao, Kaya Yoshida, Rieko Arakaki, Kazumi Ozaki, Naozumi Ishimaru and Yasusei Kudo : Fusobacterium nucleatumが与える口腔癌細胞への影響, 第38回分子病理学研究会淡路島シンポジウム(兵庫県) 2019年7月19-20日, Jul. 2019.
2.	Natsumi Fujiwara, Kazumi Ozaki, Kayo Yoshida, Yuko Takeuchi and Shizuko Yanagisawa : 口腔ケア支援体制づくりを目指した研修会の取り組みと介護関係職員の口腔ケア実施状況, 第54回日本理学療法学術研修大会in徳島2019 総合事業実践報告会 2019年5月25日(徳島県徳島市), May 2019.
3.	Kaya Yoshida, Mariko Seyama, Natsumi Fujiwara, Kazumi Ozaki, 内部健太, 池亀美華 and Hirohiko Okamura : 歯周病が糖尿病を重症化する機序について, 2018 Bioscience retreat in Awaji, Nov. 2018.
4.	Natsumi Fujiwara, Miki Tsurukuma, Kaya Yoshida, Keiji Murakami, Kazumi Ozaki, Hideki Fujii and Hiromichi Yumoto : MPCポリマーコーティングによる義歯用レジンのカンジダ付着抑制効果, 2018 Bioscience retreat in Awaji, Nov. 2018.
5.	Mariko Seyama, Kaya Yoshida, Natsumi Fujiwara and Kazumi Ozaki : Porphyromonas gingivalisの分泌小胞が肝臓インスリンシグナルに及ぼす影響について, 2017 Bioscience Retreat in Tosa, Dec. 2017.
6.	Kaya Yoshida, Mariko Seyama, Natsumi Fujiwara, Kazumi Ozaki, 内部健太, 池亀美華 and Hirohiko Okamura : Porphyromonas gingivalis感染したマクロファージはインスリンシグナル抑制因子を含むエクソソームを産生する, 2017 Bioscience Retreat in Tosa, Dec. 2017.

Report:

1.	Kazumi Ozaki, Yasuhiko Shirayama, Shizuko Yanagisawa, Natsumi Fujiwara and Yuko Takeuchi : 「ICTシステムを用いた多職種による遠隔モニタリングがもたらす食支援業務の質向上および効率化に関する実証研究」報告書, 公益社団法人全国老人福祉施設協議会(令和元年度調査研究助成事業), Apr. 2020.
2.	Kazumi Ozaki, Yasuhiko Shirayama, Tetsuo Ichikawa, Miwa Matsuyama, Yasuhiro Hamada, Shinsuke Katoh, 濵田邦美, Teruyoshi Kageji, 藤原真治, Shizuko Yanagisawa, Natsumi Fujiwara and Yuko Takeuchi : 令和元年度老人保健事業推進費等補助金(老人保健健康増進等事業)中山間地域における地域住民との連携によるオーラルフレイル予防のためのICT利活用の強化・進展に関する調査研究事業「とくしま助INTプロジェクト」報告書, 1-94, Mar. 2020.
3.	Kazumi Ozaki, Yasuhiko Shirayama, Shinsuke Katoh, Tetsuo Ichikawa, Yasuhiro Hamada, Shizuko Yanagisawa, Natsumi Fujiwara and Yuko Takeuchi : 平成30年度老人保健事業推進費等補助金(老人保健健康増進等事業)中山間地域におけるICT利活用によるフレイル・オーラルフレイル予防のためのベストプラクティス確立・普及に関する調査研究事業「阿波なかつむぎプロジェクト」報告書, 1-92, Mar. 2019.
4.	Yasuhiko Shirayama, Kazumi Ozaki, Shinsuke Katoh, Tetsuo Ichikawa, Saori Iwamoto, Shinji Nagahiro, Shizuko Yanagisawa and Natsumi Fujiwara : 「那賀イ∼と，つながる・みまもるプロジェクト」報告書, 平成29年度老人保健事業推進費等補助金中山間地域の地域包括ケアシステム構築における食支援連携促進に資するICT利活用に関する調査研究事業「那賀イーと,つながる・みまもるプロジェクト」報告書, 1-86, Mar. 2018.
5.	Kazumi Ozaki, Natsumi Fujiwara, Shizuko Yanagisawa and Yasuhiko Shirayama : 口腔ケア関連ICTツールを併用した経口摂取支援業務運用ガイドラインの策定に関する研究, 公益財団法人全国老人福祉施設協議会平成29年度全国老人福祉施設研究会議高知会議要覧, 247-252, Oct. 2017. (Keyword) 口腔健康管理 / ICTシステム / CAPDo
6.	Natsumi Fujiwara, Yumi Hoshimo, Mami Sugimoto, Tokiko Doi and Daisuke Hinode : A Report of Participation and Activity in International Week Meeting Held by Helsinki Metropolia University of Applied Sciences, Shikoku Dental Research, Vol.24, No.2, 95-98, Jan. 2012. (Tokushima University Institutional Repository) ● Metadata: 109822 (Tokushima University Institutional Repository: 109822)
7.	松本厚枝, Natsumi Fujiwara, 島津篤, 天野秀昭, 森山幸奈, 松添香菜子, 川野沙織, 柄俊彦, 足利奈々, 岩本明子, 大前侑子, 香西克之, 西村英紀 and 高田隆 : カンボジアの小学校における国際歯科支援活動の報告口腔保健学科生のかかわりについて, The Journal of Japan Society for Dental Hygiene, Vol.5, No.1, 261, 2010. (Keyword) 歯科学生; 国際協力; 歯科医療; カンボジア; 小学生 / ヒト; 成人(19∼44); 歯学

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

エビデンスを備えた口腔ケアの新展開-フゾバクテリウムが及ぼす口腔癌病態への影響- (Project/Area Number: 19K19315 )
Elucidation of serious mechanisms for aspiration pneumonia caused by oral bacteria and Pseudomonas aeruginosa~aim for the prevention of pneumonia~ (Project/Area Number: 16K21198 )
Development of oral probiotics using multi-bacteria (Project/Area Number: 25670886 )
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Professor : Fujiwara, Natsumi

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)