Tokushima University / Educator and Researcher Directory --- Mure, Hideo

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Book:

1.	Hideo Mure : ナーシング・グラフィカ健康の回復と看護4 脳・神経機能障害/感覚機能障害 1章5節脊髄, Medicus SHUPPAN, Osaka, Jan. 2016.

Academic Paper (Judged Full Paper):

1.	Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi : Cranial geometry in patients with dystonia and Parkinson's disease., Scientific Reports, Vol.13, No.1, 2023. (Summary) Abnormal skull shape has been reported in brain disorders. However, no studies have investigated cranial geometry in neurodegenerative disorders. This study aimed to evaluate the cranial geometry of patients with dystonia or Parkinson's disease (PD). Cranial computed tomography images of 36 patients each with idiopathic dystonia (IDYS), PD, and chronic subdural hematoma (CSDH) were analyzed. Those with IDYS had a significantly higher occipital index (OI) than those with CSDH (p = 0.014). When cephalic index (CI) was divided into the normal and abnormal groups, there was a significant difference between those with IDYS and CSDH (p = 0.000, α = 0.017) and between PD and CSDH (p = 0.031, α = 0.033). The age of onset was significantly correlated with the CI of IDYS (τ = - 0.282, p = 0.016). The Burke-Fahn-Marsden Dystonia Rating Scale motor score (BFMDRS-M) showed a significant correlation with OI in IDYS (τ = 0.372, p = 0.002). The cranial geometry of patients with IDYS was significantly different from that of patients with CSDH. There was a significant correlation between age of onset and CI, as well as between BFMDRS-M and OI, suggesting that short heads in the growth phase and skull balance might be related to the genesis of dystonia and its effect on motor symptoms. (Keyword) Humans / Dystonia / Parkinson Disease / Treatment Outcome / Deep Brain Stimulation / Dystonic Disorders / Skull / Hematoma, Subdural, Chronic / Globus Pallidus (Tokushima University Institutional Repository) ● Metadata: 118394 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-023-37833-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37420081 ● Search Scopus @ Elsevier (PMID): 37420081 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-37833-3 (Tokushima University Institutional Repository: 118394, DOI: 10.1038/s41598-023-37833-3, PubMed: 37420081)
2.	Hiroshi Koyama, Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Satoshi Goto and Yasushi Takagi : Long-Term Follow-Up of 12 Patients Treated with Bilateral Pallidal Stimulation for Tardive Dystonia, Life, Vol.11, No.6, 477, 2021. (Summary) Tardive dystonia (TD) is a side effect of prolonged dopamine receptor antagonist intake. TD can be a chronic disabling movement disorder despite medical treatment. We previously demonstrated successful outcomes in six patients with TD using deep brain stimulation (DBS); however, more patients are needed to better understand the efficacy of DBS for treating TD. We assessed the outcomes of 12 patients with TD who underwent globus pallidus internus (GPi) DBS by extending the follow-up period of previously reported patients and enrolling six additional patients. All patients were refractory to pharmacotherapy and were referred for surgical intervention by movement disorder neurologists. In all patients, DBS electrodes were implanted bilaterally within the GPi under general anesthesia. The mean ages at TD onset and surgery were 39.2 ± 12.3 years and 44.6 ± 12.3 years, respectively. The Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) performed the preoperative and postoperative evaluations. The average BFMDRS improvement rate at 1 month postoperatively was 75.6 ± 27.6% ( < 0.001). Ten patients were assessed in the long term (78.0 ± 50.4 months after surgery), and the long-term BFMDRS improvement was 78.0 ± 20.4%. Two patients responded poorly to DBS. Both had a longer duration from TD onset to surgery and older age at surgery. A cognitive and psychiatric decline was observed in the oldest patients, while no such decline ware observed in the younger patients. In most patients with TD, GPi-DBS could be a beneficial therapeutic option for long-term relief of TD. (Tokushima University Institutional Repository) ● Metadata: 116561 (Link to Publication Site) ● Publication site (DOI): 10.3390/life11060477 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34074009 ● Summary page in Scopus @ Elsevier: 2-s2.0-85107554331 (Tokushima University Institutional Repository: 116561, DOI: 10.3390/life11060477, PubMed: 34074009, Elsevier: Scopus)
3.	Daisy Ma Tabuena, Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Nobuaki Yamamoto, Kazuhisa Miyake, Taku Matsuda, Yuishin Izumi, Yasushi Takagi, P Rollin Tabuena and Toshitaka Kawarai : Ataxia with vitamin E deficiency in the Philippines: A case report of two siblings., The Journal of Medical Investigation : JMI, Vol.68, No.3.4, 400-403, 2021. (Summary) Here we report two siblings with ataxia and peripheral neuropathy. One patient showed head tremors. Genetic analysis revealed a mutation in the hepatic α-tocopherol transfer protein (α-TTP) gene (TTPA) on chromosome 8q13. They were diagnosed with ataxia with vitamin E deficiency which is firstly reported in the Philippines. As the symptoms of ataxia with vitamin E deficiency can be alleviated with lifelong vitamin E administration, differential diagnosis from similar syndromes is important. In addition, ataxia with vitamin E deficiency causes movement disorders. Therefore, a common hereditary disease in the Philippines, X-linked dystonia-parkinsonism, could be another differential diagnosis. The Philippines is an archipelago comprising 7,107 islands, and the prevalence of rare hereditary diseases among the populations of small islands is still unclear. For neurologists, establishing a system of genetic diagnosis and counseling in rural areas remains challenging. These unresolved problems should be addressed in the near future. J. Med. Invest. 68 : 400-403, August, 2021. (Keyword) Ataxia / Humans / Philippines / Siblings / Vitamin E Deficiency (Tokushima University Institutional Repository) ● Metadata: 116574 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.68.400 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34759169 ● Search Scopus @ Elsevier (PMID): 34759169 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.68.400 (Tokushima University Institutional Repository: 116574, DOI: 10.2152/jmi.68.400, PubMed: 34759169)
4.	Hiroki Yamazaki, 高松直子, Hiroyuki Nodera, Taku Matsuda, Hideo Mure, 安田宗義 and Yuishin Izumi : 神経超音波を用いた症状誘発肢位での動的評価が診断の一助となった真の神経原性胸部出口症候群の1例, Japanese Journal of Clinical Neurophysiology, Vol.49, No.6, 85-88, 2021.
5.	Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Koji Fujita, Taku Matsuda, Yoko Yamamoto, Masahito Nakataki, Tetsuya Okahisa, Yuki Matsumoto, Kazuhisa Miyake, Nobuaki Yamamoto, Ryuji Kaji, Yasushi Takagi and Satoshi Goto : Can Pallidal Deep Brain Stimulation Rescue Borderline Dystonia? Possible Coexistence of Functional (Psychogenic) and Organic Components., Brain Sciences, Vol.10, No.9, 636, 2020. (Summary) The diagnosis and treatment of functional movement disorders are challenging for clinicians who manage patients with movement disorders. The borderline between functional and organic dystonia is often ambiguous. Patients with functional dystonia are poor responders to pallidal deep brain stimulation (DBS) and are not good candidates for DBS surgery. Thus, if patients with medically refractory dystonia have functional features, they are usually left untreated with DBS surgery. In order to investigate the outcome of functional dystonia in response to pallidal DBS surgery, we retrospectively included five patients with this condition. Their dystonia was diagnosed as organic by dystonia specialists and also as functional according to the Fahn and Williams criteria or the Gupta and Lang Proposed Revisions. Microelectrode recordings in the globus pallidus internus of all patients showed a cell-firing pattern of bursting with interburst intervals, which is considered typical of organic dystonia. Although their clinical course after DBS surgery was incongruent to organic dystonia, the outcome was good. Our results question the possibility to clearly differentiate functional dystonia from organic dystonia. We hypothesized that functional dystonia can coexist with organic dystonia, and that medically intractable dystonia with combined functional and organic features can be successfully treated by DBS surgery. (Tokushima University Institutional Repository) ● Metadata: 116502 (Link to Publication Site) ● Publication site (DOI): 10.3390/brainsci10090636 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32942724 ● Search Scopus @ Elsevier (PMID): 32942724 ● Search Scopus @ Elsevier (DOI): 10.3390/brainsci10090636 (Tokushima University Institutional Repository: 116502, DOI: 10.3390/brainsci10090636, PubMed: 32942724)
6.	Hideo Mure, Naoto Toyoda, Ryoma Morigaki, Koji Fujita and Yasushi Takagi : Clinical Outcome and Intraoperative Neurophysiology of the Lance-Adams Syndrome Treated with Bilateral Deep Brain Stimulation of the Globus Pallidus Internus: A Case Report and Review of the Literature., Stereotactic and Functional Neurosurgery, Vol.98, No.6, 399-403, 2020. (Summary) Our results show that impairment in the basal ganglion circuitry might be involved in the pathogenesis of myoclonus in patients with LAS. (Keyword) Aged / Deep Brain Stimulation / Female / Globus Pallidus / Humans / Hypoxia-Ischemia, Brain / Intraoperative Neurophysiological Monitoring / Microelectrodes / Myoclonus / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1159/000509318 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32894852 ● Search Scopus @ Elsevier (PMID): 32894852 ● Search Scopus @ Elsevier (DOI): 10.1159/000509318 (DOI: 10.1159/000509318, PubMed: 32894852)
7.	Yamamoto Yuki, Nobuaki Yamamoto, Koji Fujita, Fukumoto Tatsuya, Murakami Nagahisa, Hideo Mure, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi : Cerebral Venous Thrombosis: An Unexpected Complication with Cerebrospinal Fluid Leaks after a Fall in a Patient with Spinocerebellar Ataxia Type 6., Internal Medicine, Vol.59, No.14, 1749-1753, 2020. (Tokushima University Institutional Repository) ● Metadata: 115918 (Link to Publication Site) ● Publication site (DOI): 10.2169/internalmedicine.4388-20 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32238726 ● Search Scopus @ Elsevier (PMID): 32238726 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.4388-20 (Tokushima University Institutional Repository: 115918, DOI: 10.2169/internalmedicine.4388-20, PubMed: 32238726)
8.	Koji Bando, Toshiyuki Okazaki, Hideo Mure, Masaaki Korai and Hiroshi Kagusa : A Juvenile Case of Bow Hunter's Syndrome Caused by Atlantoaxial Dislocation with Vertebral Artery Dissecting Aneurysm., World Neurosurgery, Vol.137, 393-397, 2020. (Summary) Bow hunter's syndrome (BHS) is caused by posterior circulation insufficiency that results from the occlusion or compression of the vertebral artery (VA) during neck rotation. Owing to its rarity, there is no guideline to support the decision of selecting a conservative or a surgical approach. Management of BHS is dependent on each patient. A 13-year-old girl presented with transient visual disturbance, hypoesthesia, and paralysis of the left side of the body. Magnetic resonance imaging revealed an acute cerebral infarction in the right thalamus, and magnetic resonance angiography demonstrated occlusion of the right posterior cerebral artery and dilation of V3 of the left VA. Digital subtraction angiography revealed a left VA dissecting aneurysm at V3 and left VA occlusion at the level of C1-C2 during neck rotation to the right. A dynamic x-ray suggested atlantoaxial joint instability, and three-dimensional computed tomography revealed aplasia of C1 lamina and atlantoaxial rotatory dislocation. BHS with left VA dissecting aneurysm caused by atlantoaxial rotatory dislocation was diagnosed. We performed C1-C2 posterior fusion by the Goel-Harms technique. Stroke did not recur, and computed tomography angiography obtained 8 months postoperatively demonstrated a decrease in the dissecting aneurysm. To our knowledge, this is the first case of BHS with VA dissecting aneurysm and aplasia of C1 lamina. Based on this case, we suggest that C1-C2 posterior fusion is effective for BHS with VA dissecting aneurysm. (Keyword) Adolescent / Aneurysm, Dissecting / Atlanto-Axial Joint / Cervical Atlas / Computed Tomography Angiography / female / Humans / Imaging, Three-Dimensional / Infarction, Posterior Cerebral Artery / Joint Dislocations / Magnetic Resonance Angiography / Rotation / Spinal Fusion / Vertebral Artery Dissection / Vertebrobasilar Insufficiency (Link to Publication Site) ● Publication site (DOI): 10.1016/j.wneu.2020.02.041 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32068175 ● Search Scopus @ Elsevier (PMID): 32068175 ● Search Scopus @ Elsevier (DOI): 10.1016/j.wneu.2020.02.041 (DOI: 10.1016/j.wneu.2020.02.041, PubMed: 32068175)
9.	Akemi Hioka, Yoshiteru Tada, Keiko Kitazato, Yasuhisa Kanematsu, Yoshifumi Mizobuchi, Hideo Mure, Kenji Shimada, Toshiyuki Okazaki, Masaaki Korai, Noki Akazawa, Yuki Matsumoto, Yuki Matsumoto, Yasushi Takagi and Shinji Nagahiro : Activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons., Journal of Clinical Neuroscience, Vol.60, 79-83, 2019. (Summary) The observation of walking improves gait ability in chronic stroke survivors. It has also been suggested that activation of the mirror neuron system contributes to this effect. However, activation of the mirror neuron system during gait observation has not yet been assessed in sub-acute stroke patients. The objective of this study was to clarify the activation of mirror neuron system during gait observation in sub-acute stroke patients and healthy persons. In this study, we sequentially enrolled five sub-acute stroke patients who had undergone gait training and nine healthy persons. We used fMRI to detect neuronal activation during gait observation. During the observation period in the stroke group, neural activity in the left inferior parietal lobule, right and left inferior frontal gyrus was significantly higher than during the rest period. In the healthy group, neural activity in the left inferior parietal lobule, left inferior frontal gyrus, left middle frontal gyrus, left superior temporal lobule and right and left middle temporal gyrus was significantly higher than during the rest period. The results indicate that the mirror neuron system was activated during gait observation in sub-acute stroke patients who had undergone gait training and also in healthy persons. Our findings suggest that gait observation treatment may provide a promising therapeutic strategy in sub-acute stroke patients who have experienced gait training. (Keyword) Adult / Brain / Exercise Therapy / Female / Gait / Humans / Magnetic Resonance Imaging / Male / Middle Aged / Mirror Neurons / Stroke / Stroke Rehabilitation (Tokushima University Institutional Repository) ● Metadata: 113267 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jocn.2018.09.035 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30318398 ● Search Scopus @ Elsevier (PMID): 30318398 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jocn.2018.09.035 (Tokushima University Institutional Repository: 113267, DOI: 10.1016/j.jocn.2018.09.035, PubMed: 30318398)
10.	Yoshifumi Mizobuchi, Kohhei Nakajima, Toshitaka Fujihara, Kazuhito Matsuzaki, Hideo Mure, Shinji Nagahiro and Yasushi Takagi : The risk of hemorrhage in stereotactic biopsy for brain tumors., The Journal of Medical Investigation : JMI, Vol.66, No.3,4, 314-318, 2019. (Summary) Objective : One major complication associated with STB is intratumoral hematoma, which is also the most common cause of morbidity related to permanent paralysis and mortality in STB. The risk of perioperative hemorrhage is generally between 1% and 10%, but this could be an underestimation since it is not common for many neurosurgeons to perform CT scans after uncomplicated STBs. In this study, we describe the incidence of cerebral hemorrhage, including asymptomatic cerebral hemorrhage. Methods : We recently reviewed data on the diagnosis rate and occurrence of complications, including symptomatic and asymptomatic cerebral hemorrhage, in 80 patients who underwent STB at our facility between 2005 and 2014. Results : Histological diagnosis was established for 75 cases (93.8%), glioma was the most frequently encountered tumor. Symptomatic hemorrhage was observed in two cases (2.6%), with the symptoms subsiding within two days. The morbidity and mortality rate was 0%. However, asymptomatic hemorrhages were observed in 23 cases (28.8%). Conclusion : Stereotactic biopsy is a less invasive procedure for obtaining samples of brain tumors for diagnosis. The bleeding of the tissue-resection cavity that includes asymptomatic hemorrhage occurs at a constant rate. It is important to reduce the symptomatic bleeding associated with stereotactic biopsy. J. Med. Invest. 66 : 314-318, August, 2019. (Keyword) Adolescent / Adult / Aged / Aged, 80 and over / Biopsy / Brain / Brain Neoplasms / Cerebral Hemorrhage / Female / Humans / Male / Middle Aged / Stereotaxic Techniques / Young Adult (Tokushima University Institutional Repository) ● Metadata: 114088 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.66.314 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31656296 ● Search Scopus @ Elsevier (PMID): 31656296 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.66.314 (Tokushima University Institutional Repository: 114088, DOI: 10.2152/jmi.66.314, PubMed: 31656296)
11.	Toshiyuki Okazaki, H Nakagawa, Hideo Mure, Kenji Yagi, H Hayase, Yasushi Takagi and K Saito : Microdiscectomy and Foraminotomy in Cervical Spondylotic Myelopathy and Radiculopathy, Neurologia Medico-Chirurgica, Vol.58, No.11, 468-476, 2018. (Summary) This study was to assess the efficacy of microdiscectomy, cage fixation, and right tranuncal foramintomy for the patients suffering from right radiulo-myelopathy. Anterior cervical foraminotomy was reported to be an effective option for the treatment of cervical degenerative radiculopathy but with the problem of recurrence. Since Hakuba reported the method of trans-unco-discal approach in 1976, it was designed as keyhole foraminotomy which was called transuncal approach, transpedicular approach or transvertebral approach. In the anterior approach, we usually use the right-sided approach because most of us are right-handed surgeons. We retrospectively investigated our patients who had the right foraminal stenosis causing radiculopathy and were treated with microdiscectomy, cage fixation, and right keyhole transuncal foraminotomy. Since 2011, 23 patients were treated with the manner. All of the 23 patients who had central canal stenosis and among the 23 patients, 8 patients showed only right radiculopathy and 15 patients showed radiculo-myelopathy. In all patients, the radiculopathy disappeared or significantly improved without any complications postoperatively. The average of VAS scores was 7.6 ± 2.2 in preoperative state, 2.8 ± 2.2 at discharge, and 1.1 ± 1.6 in 1 month after surgery. The average of follow-up time was 38.3 months and they had no recurrence of radiculopathy. We showed that this manner is effective and one option for the combined disease of right foraminal and canal stenosis and we believe that this manner is not complex and safe if we can understand the anatomy. (Keyword) Adult / Aged / Diskectomy / Female / Foraminotomy / Humans / Male / Middle Aged / Radiculopathy / Retrospective Studies / Spinal Cord Diseases / Spinal Stenosis / Spondylosis / Treatment Outcome (Tokushima University Institutional Repository) ● Metadata: 119193 (Link to Publication Site) ● Publication site (DOI): 10.2176/nmc.oa.2018-0077 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30298831 ● Search Scopus @ Elsevier (PMID): 30298831 ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.oa.2018-0077 (Tokushima University Institutional Repository: 119193, DOI: 10.2176/nmc.oa.2018-0077, PubMed: 30298831)
12.	Shinji Nagahiro, Yoshiteru Tada, Junichiro Satomi, Tomoya Kinouchi, Kazuyuki Kuwayama, Kenji Yagi, Kohhei Nakajima, Nobuhisa Matsushita, Takeshi Miyamoto, Tadashi Yamaguchi, Kenji Shimada, Masaaki Korai, Hideo Mure, Y Okayama, Takashi Abe, Masafumi Harada, Keiko T. Kitazato and Yasuhisa Kanematsu : Treatment of Unruptured Cerebral Aneurysms with the Mineralocorticoid Receptor Blocker Eplerenone-Pilot Study., Journal of Stroke & Cerebrovascular Diseases, Vol.27, No.8, 2134-2140, 2018. (Summary) Currently there are no pharmacological therapies for patients with unruptured cerebral aneurysms. Elsewhere we showed that the mineralocorticoid receptor antagonist eplerenone prevented the formation of cerebral aneurysms in our ovariectomized hypertensive aneurysm rat model. The current pilot study evaluated whether it can be used to prevent the growth and rupture of cerebral aneurysms in hypertensive patients. Between August 2011 and May 2014, we enrolled 82 patients with 90 aneurysms in an open-label uncontrolled clinical trial. All provided prior informed consent for inclusion in this study, and all were treated with eplerenone (25-100 mg/d). The primary end points of our study were the rupture and enlargement of the cerebral aneurysms. Of the 82 patients, 80 (88 unruptured aneurysms) were followed for a mean of 21.3 months (153.4 aneurysm-years); 12 patients (15.0%) permanently discontinued taking the drug. One month after the start of eplerenone administration and throughout the follow-up period, eplerenone kept the blood pressure within the normal range. Most notably, no aneurysms smaller than 9 mm ruptured or enlarged. However, of 2 large thrombosed aneurysms, 1 enlarged and the other ruptured. The overall annual rupture rate was .65%; it was 13.16% for aneurysms larger than 10 mm; the overall annual rate for reaching the primary end points was 1.30%. Our observations suggest that eplerenone may help to prevent the growth and rupture of unruptured cerebral aneurysms smaller than 9 mm. To assess its potential long-term clinical benefits, large clinical trials are needed. (Keyword) Aged / Aneurysm, Ruptured / brain / Disease Progression / female / Follow-Up Studies / Humans / Intracranial Aneurysm / male / Mineralocorticoid Receptor Antagonists / Neuroprotective Agents / Pilot Projects / Spironolactone / Treatment Outcome (Tokushima University Institutional Repository) ● Metadata: 115570 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2018.03.008 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29622372 ● Summary page in Scopus @ Elsevier: 2-s2.0-85049537109 (Tokushima University Institutional Repository: 115570, DOI: 10.1016/j.jstrokecerebrovasdis.2018.03.008, PubMed: 29622372, Elsevier: Scopus)
13.	N Enomoto, Hideo Mure, Toshiyuki Okazaki, M Azumi, S Okita, Shinji Nagahiro and Yasushi Takagi : Posttraumatic Cerebrospinal Fluid Leak Associated with an Upper Cervical Meningeal Diverticulum, World Neurosurgery, Vol.116, 50-55, 2018. (Summary) Spontaneous intracranial hypotension (SIH) has been increasingly recognized as a phenomenon caused by cerebrospinal fluid (CSF) leaks; however, its pathogenesis remains unclear. We report 2 cases of SIH resulting from CSF leak from a meningeal diverticulum at the C2 nerve root sleeve. The first case is that of a 46-year-old man who experienced orthostatic headache after a bicycle accident at age 45. Computed tomography (CT) myelography revealed CSF leaks at the C1-2 level. He underwent epidural blood patch therapy, but it was unsuccessful. Next, we performed direct surgery and found a meningeal diverticulum originating from the left C2 nerve root; therefore, we ligated the diverticulum. His symptoms and image findings strikingly improved after surgery. The second case is that of a 45-year-old man who experienced orthostatic headache 1 month after jumping into a river. Magnetic resonance imaging of the head showed bilateral subdural hematoma. CT myelography revealed CSF leaks at the C1-2 level and multiple cyst formations at the cervical and thoracic nerve root sleeves. epidural blood patch was performed, and his symptoms immediately improved. Recent studies have reported that meningeal diverticulum is involved in various cases of CSF leaks. The 2 cases indicate that traumatic accidents, such as back-and-forth neck movement or falls, presumably induce an increase in CSF pressure, followed by the rupture of an existing meningeal diverticulum, leading to CSF leak. (Keyword) Blood Patch, Epidural / Brain Injuries, Traumatic / Cerebrospinal Fluid Leak / Cervical Vertebrae / Diverticulum / Humans / Male / Meninges / Middle Aged (Link to Publication Site) ● Publication site (DOI): 10.1016/j.wneu.2018.05.061 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29777885 ● Summary page in Scopus @ Elsevier: 2-s2.0-85047768412 (DOI: 10.1016/j.wneu.2018.05.061, PubMed: 29777885, Elsevier: Scopus)
14.	Toshitaka Fujihara, Yoshifumi Mizobuchi, Kohhei Nakajima, Teruyoshi Kageji, Kazuhito Matsuzaki, KT Kitazato, Ryotaro Otsuka, Keijiro Hara, Hideo Mure, Toshiyuki Okazaki, Kazuyuki Kuwayama, Shinji Nagahiro and Yasushi Takagi : Down-regulation of MDR1 by Ad-DKK3 via Akt/NFB pathways augments the anti-tumor effect of temozolomide in glioblastoma cells and a murine xenograft model, Journal of Neuro-Oncology, Vol.139, No.2, 323-332, 2018. (Summary) Glioblastoma multiforme (GBM) is the most malignant of brain tumors. Acquired drug resistance is a major obstacle for successful treatment. Earlier studies reported that expression of the multiple drug resistance gene (MDR1) is regulated by YB-1 or NFκB via the JNK/c-Jun or Akt pathway. Over-expression of the Dickkopf (DKK) family member DKK3 by an adenovirus vector carrying DKK3 (Ad-DKK3) exerted anti-tumor effects and led to the activation of the JNK/c-Jun pathway. We investigated whether Ad-DKK3 augments the anti-tumor effect of temozolomide (TMZ) via the regulation of MDR1. GBM cells (U87MG and U251MG), primary TGB105 cells, and mice xenografted with U87MG cells were treated with Ad-DKK3 or TMZ alone or in combination. Ad-DKK3 augmentation of the anti-tumor effects of TMZ was associated with reduced MDR1 expression in both in vivo and in vitro studies. The survival of Ad-DKK3-treated U87MG cells was inhibited and the expression of MDR1 was reduced. This was associated with the inhibition of Akt/NFκB but not of YB-1 via the JNK/c-Jun- or Akt pathway. Our results suggest that Ad-DKK3 regulates the expression of MDR1 via Akt/NFκB pathways and that it augments the anti-tumor effects of TMZ in GBM cells. (Tokushima University Institutional Repository) ● Metadata: 112895 (Link to Publication Site) ● Publication site (DOI): 10.1007/s11060-018-2894-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29779087 ● Summary page in Scopus @ Elsevier: 2-s2.0-85047143200 (Tokushima University Institutional Repository: 112895, DOI: 10.1007/s11060-018-2894-5, PubMed: 29779087, Elsevier: Scopus)
15.	Toshitaka Kawarai, Ryosuke Miyamoto, Eiji Nakagawa, Reiko Koichihara, Takashi Sakamoto, Hideo Mure, Ryoma Morigaki, Hidetaka Koizumi, Ryosuke Oki, Celeste Montecchiani, Carlo Caltagirone, Antonio Orlacchio, Ayako Hattori, Hideaki Mashimo, Yuishin Izumi, Takahiro Mezaki, Satoko Kumada, Makoto Taniguchi, Fusako Yokochi, Shinji Saitoh, Satoshi Goto and Ryuji Kaji : Phenotype variability and allelic heterogeneity in KMT2B-Associated disease., Parkinsonism & Related Disorders, 2018. (Summary) We further demonstrate the allelic heterogeneity and phenotypic variations of KMT2B-associated disease. Haploinsufficiency is one of molecular pathomechanisms underlying the disease. Cardinal clinical features include combined dystonia accompanying mild psychomotor disability. Cerebellum would be affected in KMT2B-associated disease. (Keyword) Dystonia (Link to Publication Site) ● Publication site (DOI): 10.1016/j.parkreldis.2018.03.022 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29653907 ● Search Scopus @ Elsevier (PMID): 29653907 ● Search Scopus @ Elsevier (DOI): 10.1016/j.parkreldis.2018.03.022 (DOI: 10.1016/j.parkreldis.2018.03.022, PubMed: 29653907)
16.	Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Masahito Nakataki, 岡久哲也, Shinsuke Katoh, Ryuji Kaji, Yasushi Takagi, Shinji Nagahiro and Satoshi Goto : Multi-disciplinary approach for dystonia patients by treatment with deep brain stimulation, Functional Neurosurgery, Vol.57, 35-39, 2018. (Keyword) ジストニア / 脳深部刺激療法 / 多職種連携 / Dystonia / DBS / Multidisciplinary / Collaboration (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572358412476800 (CiNii: 1520572358412476800)
17.	Hideo Mure, Motohiro Hirasawa and Shinji Nagahiro : パーキンソン病と腰痛脊髄刺激療法適応と課題, Clinical Orthopaedic Surgery, Vol.52, No.9, 861-867, 2017. (Link to Publication Site) ● Publication site (DOI): 10.11477/mf.1408200907 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1408200907 (DOI: 10.11477/mf.1408200907)
18.	Shu Sogabe, Junichiro Satomi, Yoshiteru Tada, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Kenji Yagi, Shotaroh Yoshioka, Yoshifumi Mizobuchi, Hideo Mure, Izumi Yamaguchi, Takashi Abe, Nobuaki Yamamoto, Keiko Kitazato, Ryuji Kaji, Masafumi Harada and Shinji Nagahiro : Intra-arterial high signals on arterial spin labeling perfusion images predict the occluded internal carotid artery segment, Neuroradiology, Vol.59, No.6, 587-595, 2017. (Summary) Arterial spin labeling (ASL) involves perfusion imaging using the inverted magnetization of arterial water. If the arterial arrival times are longer than the post-labeling delay, labeled spins are visible on ASL images as bright, high intra-arterial signals (IASs); such signals were found within occluded vessels of patients with acute ischemic stroke. The identification of the occluded segment in the internal carotid artery (ICA) is crucial for endovascular treatment. We tested our hypothesis that high IASs on ASL images can predict the occluded segment. Our study included 13 patients with acute ICA occlusion who had undergone angiographic and ASL studies within 48 h of onset. We retrospectively identified the high IAS on ASL images and angiograms and recorded the occluded segment and the number of high IAS-positive slices on ASL images. The ICA segments were classified as cervical (C1), petrous (C2), cavernous (C3), and supraclinoid (C4). Of seven patients with intracranial ICA occlusion, five demonstrated high IASs at C1-C2, suggesting that high IASs could identify stagnant flow proximal to the occluded segment. Among six patients with extracranial ICA occlusion, five presented with high IASs at C3-C4, suggesting that signals could identify the collateral flow via the ophthalmic artery. None had high IASs at C1-C2. The mean number of high IAS-positive slices was significantly higher in patients with intra- than extracranial ICA occlusion. High IASs on ASL images can identify slow stagnant and collateral flow through the ophthalmic artery in patients with acute ICA occlusion and help to predict the occlusion site. (Tokushima University Institutional Repository) ● Metadata: 111444 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00234-017-1828-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28397019 ● Search Scopus @ Elsevier (PMID): 28397019 ● Search Scopus @ Elsevier (DOI): 10.1007/s00234-017-1828-9 (Tokushima University Institutional Repository: 111444, DOI: 10.1007/s00234-017-1828-9, PubMed: 28397019)
19.	Aya Sato, Yoshifumi Mizobuchi, Kohhei Nakajima, Kenji Shono, Toshitaka Fujihara, Teruyoshi Kageji, Keiko Kitazato, Kazuhito Matsuzaki, Hideo Mure, Kazuyuki Kuwayama, Akiko Sumi, Hideyuki Saya, Oltea Sampetrean and Shinji Nagahiro : Blocking COX-2 induces apoptosis and inhibits cell proliferation via the Akt/survivin- and Akt/ID3 pathway in low-grade-glioma., Journal of Neuro-Oncology, Vol.132, No.2, 231-238, 2017. (Summary) Approximately half of surgically-treated patients with low-grade-glioma (LGG) suffer recurrence or metastasis. Currently there is no effective drug treatment. While the selective COX-2 inhibitor celecoxib showed anti-neoplastic activity against several malignant tumors, its effects against LGG remain to be elucidated. Ours is the first report that the expression level of COX-2 in brain tissue samples from patients with LGG and in LGG cell lines is higher than in the non-neoplastic region and in normal brain cells. We found that celecoxib attenuated LGG cell proliferation in a dose-dependent manner. It inhibited the generation of prostaglandin E2 and induced apoptosis and cell-cycle arrest. We also show that celecoxib hampered the activation of the Akt/survivin- and the Akt/ID3 pathway in LGGs. These findings suggest that celecoxib may have a promising therapeutic potential and that the early treatment of LGG patients with the drug may be beneficial. (Keyword) Animals / Apoptosis / Brain / Brain Neoplasms / Celecoxib / Cell Line, Tumor / Cell Proliferation / Cyclooxygenase 2 / Cyclooxygenase 2 Inhibitors / Enzyme Inhibitors / Female / Gene Expression Regulation, Neoplastic / Glioma / Humans / Inhibitor of Apoptosis Proteins / Inhibitor of Differentiation Proteins / Male / Mice / Mice, Inbred C57BL / Mice, Transgenic / Neoplasm Proteins / Proto-Oncogene Proteins c-akt / Signal Transduction (Tokushima University Institutional Repository) ● Metadata: 115523 (Link to Publication Site) ● Publication site (DOI): 10.1007/s11060-017-2380-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28283800 ● Search Scopus @ Elsevier (PMID): 28283800 ● Search Scopus @ Elsevier (DOI): 10.1007/s11060-017-2380-5 (Tokushima University Institutional Repository: 115523, DOI: 10.1007/s11060-017-2380-5, PubMed: 28283800)
20.	Kenji Yagi, Hiroshi Nakagawa, Hideo Mure, Shinya Ohkita and Shinji Nagahiro : Cryptic Recanalization of Chronic Vertebral Artery Occlusion by Head Rotation, Journal of Stroke & Cerebrovascular Diseases, Vol.26, No.4, e60--e61, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jstrokecerebrovasdis.2016.12.034 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85009742418 (DOI: 10.1016/j.jstrokecerebrovasdis.2016.12.034, Elsevier: Scopus)
21.	Hideo Mure, Ryoma Morigaki, Shinya Ohkita, Ryosuke Miyamoto, Ryuji Kaji, Shinji Nagahiro and Satoshi Goto : ジストニアに対する脳深部刺激療法:淡蒼球刺激と視床刺激の併用, Functional Neurosurgery, Vol.55, 80-86, 2016. (Keyword) ジストニア / 脳深部刺激療法 / 淡蒼球内接 / 視床吻腹側核 / Dystonia / DBS / GPi / Thalamic Vo nucleus (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520853833839457024 (CiNii: 1520853833839457024)
22.	Ryoma Morigaki, Hideo Mure, Ryuji Kaji, Shinji Nagahiro and Satoshi Goto : Therapeutic Perspective on Tardive Syndrome with Special Reference to Deep Brain Stimulation, Frontiers in Psychiatry, Vol.7, 207, 2016. (Summary) Tardive syndrome (TDS) is a potentially permanent and irreversible hyperkinetic movement disorder caused by exposure to dopamine receptor blocking agents. Guidelines published by the American Academy of Neurology recommend pharmacological first-line treatment for TDS with clonazepam (level B), ginkgo biloba (level B), amantadine (level C), and tetrabenazine (level C). Recently, a class II study provided level C evidence for use of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in patients with TDS. Although the precise pathogenesis of TDS remains to be elucidated, the beneficial effects of GPi-DBS in patients with TDS suggest that the disease may be a basal ganglia disorder. In addition to recent advances in understanding the pathophysiology of TDS, this article introduces the current use of DBS in the treatment of medically intractable TDS. (Tokushima University Institutional Repository) ● Metadata: 114470 (Link to Publication Site) ● Publication site (DOI): 10.3389/fpsyt.2016.00207 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28082923 ● Summary page in Scopus @ Elsevier: 2-s2.0-85009160109 (Tokushima University Institutional Repository: 114470, DOI: 10.3389/fpsyt.2016.00207, PubMed: 28082923, Elsevier: Scopus)
23.	Hideo Mure : パーキンソン病における脳代謝ネットワークパターン, Cerebral Blood Flow and Metabolism, Vol.27, No.2, 313-317, 2016. (Link to Publication Site) ● Publication site (DOI): 10.16977/cbfm.27.2_313 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205756310912 ● Search Scopus @ Elsevier (DOI): 10.16977/cbfm.27.2_313 (DOI: 10.16977/cbfm.27.2_313, CiNii: 1390001205756310912)
24.	Shinya Ohkita, Hideo Mure, Ryoma Morigaki, Shinji Nagahiro and Satoshi Goto : 小児の全身性ジストニアに対し脳深部刺激術を施行した1例, 小児の脳神経, Vol.41, No.1, 86, 2016.
25.	Hideo Mure, David Eidelberg and Satoshi Goto : Brain Network Metabolic Changes in Patients with Parkinsonian Tremors, Challenges in Parkinson's Disease, 2016. (Link to Publication Site) ● Publication site (DOI): 10.5772/63159 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.5772/63159 (DOI: 10.5772/63159)
26.	Ryoma Morigaki, Ryosuke Miyamoto, Shinya Ohkita, Yoshifumi Mizobuchi, Hideo Mure, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto : Nuclear factor kappa b is under the control of dopamine signaling in the mouse striatum, Neurologia Medico-Chirurgica, Vol.55, 305, 2016.
27.	Ryosuke Miyamoto, Hiroyuki Sumikura, Toshiaki Takeuchi, Mitsuru Sanada, Koji Fujita, Toshitaka Kawarai, Hideo Mure, Ryoma Morigaki, Satoshi Goto, Shigeo Murayama, Yuishin Izumi and Ryuji Kaji : Autopsy case of severe generalized dystonia and static ataxia with marked cerebellar atrophy., Neurology, Vol.85, No.17, 1522-1524, 2015. (Keyword) Asphyxia / Atrophy / Autopsy / brain / Cerebellar Ataxia / cerebellum / Dysphonia / Dystonic Disorders / Humans / male / Middle Aged / Prone Position (Link to Publication Site) ● Publication site (DOI): 10.1212/WNL.0000000000002061 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26408497 ● Search Scopus @ Elsevier (PMID): 26408497 ● Search Scopus @ Elsevier (DOI): 10.1212/WNL.0000000000002061 (DOI: 10.1212/WNL.0000000000002061, PubMed: 26408497)
28.	Keijiro Hara, Teruyoshi Kageji, Yoshifumi Mizobuchi, Keiko T. Kitazato, Toshiyuki Okazaki, Toshitaka Fujihara, Kohhei Nakajima, Hideo Mure, Kazuyuki Kuwayama, Tomoyo Hara and Shinji Nagahiro : Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma, Cancer Letters, Vol.356, 496-505, 2015. (Summary) The effect of the third member of the Dickkopf family (DKK3) in the Wnt pathway in glioblastoma remains unclear. We first demonstrated the non-specific interaction of Wnt3a and Wnt5a with the receptors LRP6 and ROR2 and the up-regulation of the Wnt pathway in glioblastoma cells. We used an adenovirus vector and found that an increase in DKK3 protein attenuated the expression of Wnt3a, Wnt5a and LRP6, but not of ROR2, and their interaction, thereby affecting both canonical- and non-canonical Wnt downstream cascades. This produced anti-tumor effects in GBM xenograft models. The suppression of Wnt pathways upstream by DKK3 may have promise for the treatment of glioblastoma. (Keyword) Adenoviridae / Animals / apoptosis / Blotting, Western / cell proliferation and differentiation / Flow Cytometry / Genetic Vectors / Glioblastoma / Humans / Immunoenzyme Techniques / Immunoprecipitation / Intercellular Signaling Peptides and Proteins / Low Density Lipoprotein Receptor-Related Protein-6 / male / Mice / Mice, Inbred BALB C / Mice, Nude / Proto-Oncogene Proteins / RNA, Messenger / Real-Time Polymerase Chain Reaction / Receptor Tyrosine Kinase-like Orphan Receptors / Reverse Transcriptase Polymerase Chain Reaction / Tumor Cells, Cultured / Wnt Proteins / Wnt3A Protein / Xenograft Model Antitumor Assays (Tokushima University Institutional Repository) ● Metadata: 106342 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.canlet.2014.09.045 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25301448 ● Summary page in Scopus @ Elsevier: 2-s2.0-84919491383 (Tokushima University Institutional Repository: 106342, DOI: 10.1016/j.canlet.2014.09.045, PubMed: 25301448, Elsevier: Scopus)
29.	Yoshiteru Tada, Motohiro Hirasawa, Hideo Mure, Junichiro Satomi, Nobuaki Yamamoto, Takashi Abe and Shinji Nagahiro : T2強調画像で脊髄内に高信号を呈する病変圧迫骨折を伴い，両下肢の筋力低下で発症した80歳女性, Practical Currently, Vol.24, No.11, 1208-1211, 2014.
30.	Hideo Mure, Ryoma Morigaki, Hidetaka Koizumi, Shinya Okita, Toshitaka Kawarai, Ryosuke Miyamoto, Ryuji Kaji, Shinji Nagahiro and Satoshi Goto : Deep brain stimulation of the thalamic ventral lateral anterior nucleus for DYT6 dystonia., Stereotactic and Functional Neurosurgery, Vol.92, No.6, 393-396, 2014. (Summary) The thalamic VLa nucleus could serve as an alternative target in DBS therapy for DYT6 dystonia. (Keyword) dystonia / deep brain stimulation / DYT6 / mutation / hereditary dystonia (Link to Publication Site) ● Publication site (DOI): 10.1159/000365577 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25359437 ● Summary page in Scopus @ Elsevier: 2-s2.0-84910089742 (DOI: 10.1159/000365577, PubMed: 25359437, Elsevier: Scopus)
31.	Motohiro Hirasawa, Hideo Mure, Hiroyuki Toi and Shinji Nagahiro : Surgical results of lumbor interbody fusion using calcium phosphote cement, Neurologia Medico-Chirurgica, Vol.54, No.9, 722-726, 2014. (Summary) Clinical and radiological outcomes of lumbar interbody fusion using artificial fusion cages filled with calcium phosphate cements (CPCs) were retrospectively reviewed. Between 2002 and 2011, 25 patients underwent lumbar interbody fusion at Tokushima University Hospital, and 22 patients were enrolled in this study. Of these, 5 patients received autologous local bone grafts and 17 received CPC. Japan Orthopedic Association (JOA) score was used for clinical outcome assessments. Lumbar radiography and computed tomography (CT) were performed at 12, 24 months and last follow-up period to assess bony fusion. The mean JOA score of all patients improved from 9.3 before surgery to 21.0 at 24 months after surgery. Fusion had occurred in 5 of 5 patients in the local bone graft group and in 16 of 17 patients in CPC group at 24 months postoperatively. No surgically related complication was occurred in both groups. CPC is a useful and safe graft material for lumbar interbody fusion. (Link to Publication Site) ● Publication site (DOI): 10.2176/nmc.st.2013-0393 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25169138 ● Search Scopus @ Elsevier (PMID): 25169138 ● Search Scopus @ Elsevier (DOI): 10.2176/nmc.st.2013-0393 (DOI: 10.2176/nmc.st.2013-0393, PubMed: 25169138)
32.	Motohiro Hirasawa, Hideo Mure, 庄野健児, 大崎祐亮 and Shinji Nagahiro : 変形性頸椎症に伴った徐々に増大する随内高輝度病変, Practical Currently, Vol.24, No.8, 864-867, 2014.
33.	Ryoma Morigaki, Toshitaka Kawarai, Shinya Ohkita, Hideo Mure, 小泉英貴, Yoshifumi Mizobuchi, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto : X-linked dystonia-parkinsonismのニューロペプチドYシステム, Functional Neurosurgery, Vol.53, 47-55, 2014. (Keyword) X-linked dystonia-parkinsonism / DYT3 / Neuropeptide Y / Striatum / Striosome (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520290884129170304 (CiNii: 1520290884129170304)
34.	Hideo Mure, Motohiro Hirasawa and Shinji Nagahiro : 当科で経験した難治性疼痛に対する脊髄刺激療法の検討ー特にパーキンソン病に伴う腰下肢痛に関してー, Spinal Surgery, Vol.28, 287-289, 2014. (Link to Publication Site) ● Publication site (DOI): 10.2531/spinalsurg.28.287 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205231368064 ● Search Scopus @ Elsevier (DOI): 10.2531/spinalsurg.28.287 (DOI: 10.2531/spinalsurg.28.287, CiNii: 1390001205231368064)
35.	JH Ko, Hideo Mure, CC Tang, Y Ma, V Dhwawan, P Spetsieris and D Eidelberg : Parkinsons disease: increased motor network activity in the absence of movement, The Journal of Neuroscience, Vol.33, No.10, 4540-4549, 2013. (Summary) We used a network approach to assess systems-level abnormalities in motor activation in humans with Parkinson's disease (PD). This was done by measuring the expression of the normal movement-related activation pattern (NMRP), a previously validated activation network deployed by healthy subjects during motor performance. In this study, NMRP expression was prospectively quantified in (15)O-water PET scans from a PD patient cohort comprised of a longitudinal early-stage group (n = 12) scanned at baseline and at two or three follow-up visits two years apart, and a moderately advanced group scanned on and off treatment with either subthalamic nucleus deep brain stimulation (n = 14) or intravenous levodopa infusion (n = 14). For each subject and condition, we measured NMRP expression during both movement and rest. Resting expression of the abnormal PD-related metabolic covariance pattern was likewise determined in the same subjects. NMRP expression was abnormally elevated (p < 0.001) in PD patients scanned in the nonmovement rest state. By contrast, network activity measured during movement did not differ from normal (p = 0.34). In the longitudinal cohort, abnormal increases in resting NMRP expression were evident at the earliest clinical stages (p < 0.05), which progressed significantly over time (p = 0.003). Analogous network changes were present at baseline in the treatment cohort (p = 0.001). These abnormalities improved with subthalamic nucleus stimulation (p < 0.005) but not levodopa (p = 0.25). In both cohorts, the changes in NMRP expression that were observed did not correlate with concurrent PD-related metabolic covariance pattern measurements (p > 0.22). Thus, the resting state in PD is characterized by changes in the activity of normal as well as pathological brain networks. (Keyword) Aged / Antiparkinson Agents / Brain / Brain Mapping / Cerebrovascular Circulation / Cohort Studies / Deep Brain Stimulation / Deuterium Oxide / Female / Humans / Levodopa / Male / Middle Aged / Motor Activity / Neural Pathways / Parkinson Disease / Positron-Emission Tomography / Subthalamic Nucleus (Link to Publication Site) ● Publication site (DOI): 10.1523/JNEUROSCI.5024-12.2013 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23467370 ● Search Scopus @ Elsevier (PMID): 23467370 ● Search Scopus @ Elsevier (DOI): 10.1523/JNEUROSCI.5024-12.2013 (DOI: 10.1523/JNEUROSCI.5024-12.2013, PubMed: 23467370)
36.	Koji Fujita, W Sakai, Masafumi Harada, Mika Sakaki, Hideo Mure, Shinji Nagahiro, Yuishin Izumi and Ryuji Kaji : Basal ganglia hyperintensity on T1-weighted imaging of a patient with central nervous system metastasis producing carcinoembryonic antigens, Internal Medicine, Vol.52, No.3, 381-383, 2013. (Summary) We herein report unusual basal ganglia hyperintense lesions on noncontrast T1-weighted magnetic resonance imaging in a patient with central nervous system metastasis from lung adenocarcinoma that was treated with gefitinib. T2*-weighted magnetic resonance imaging showed no hypointense lesions, thereby excluding the possibility of calcification or haemorrhage. A stereotactic brain biopsy of the left basal ganglia lesions revealed atypical cells, some of which formed a glandular lumen with a micropapillary pattern. These cells were immunopositive for markers of lung adenocarcinoma, thereby confirming the diagnosis of metastasis. We speculate that proteins, including carcinoembryonic antigens from the adenocarcinoma cells in the basal ganglia, may have contributed to the hyperintensity observed on noncontrast T1-weighted magnetic resonance imaging. (Keyword) Adenocarcinoma / Basal Ganglia / Brain Neoplasms / Carcinoembryonic Antigen / Female / Humans / Lung Neoplasms / Magnetic Resonance Imaging / Middle Aged (Link to Publication Site) ● Publication site (DOI): 10.2169/internalmedicine.52.8835 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23370750 ● Summary page in Scopus @ Elsevier: 2-s2.0-84873503009 (DOI: 10.2169/internalmedicine.52.8835, PubMed: 23370750, Elsevier: Scopus)
37.	Toshiyuki Okazaki, Teruyoshi Kageji, Kazuyuki Kuwamura, Keiko T. Kitazato, Hideo Mure, Keijiro Hara, Ryoma Morigaki, Yoshifumi Mizobuchi, Kazuhito Matsuzaki and Shinji Nagahiro : Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma, Cancer Letters, Vol.323, No.2, 199-207, 2012. (Summary) Interferon-beta (IFN-) is reported to augment anti-tumor effects by temozolomide in glioblastoma via down-regulation of MGMT. Promyelocytic leukemia (PML), a gene induced by IFN-, is a tumor suppressor. Here, we report for the first time that in combination therapy, an IFN--induced increase in endogenous PML contributes to anti-tumor effects in p53 wild- and mutant glioma cells in a xenograft mice model. The increased PML promoted the accumulation of p73, a structural and functional homolog of p53, to fuse the coactivator Yes-associated-protein in the PML nuclear bodies. The adjuvant therapy targeted at PML may be a promising therapeutic strategy for glioblastoma. (Keyword) Apoptosis / Base Sequence / Blotting, Western / Brain Neoplasms / Cell Line, Tumor / DNA Primers / DNA-Binding Proteins / Dacarbazine / Glioblastoma / Humans / Interferon-beta / Nuclear Proteins / Real-Time Polymerase Chain Reaction / Transcription Factors / Tumor Suppressor Proteins / Up-Regulation (Link to Publication Site) ● Publication site (DOI): 10.1016/j.canlet.2012.04.013 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22542810 ● Search Scopus @ Elsevier (PMID): 22542810 ● Search Scopus @ Elsevier (DOI): 10.1016/j.canlet.2012.04.013 (DOI: 10.1016/j.canlet.2012.04.013, PubMed: 22542810)
38.	Hideo Mure, Chris C. Tang, Miklos Argyelan, Maria-Felice Ghilardi, Michael G. Kaplitt, Vijay Dhawan and David Eidelberg : Improved sequence learning with subthalamic nucleus deep brain stimulation: evidence for treatment-specific network modulation., The Journal of Neuroscience, Vol.32, No.8, 2804-2813, 2012. (Summary) We used a network approach to study the effects of anti-parkinsonian treatment on motor sequence learning in humans. Eight Parkinson's disease (PD) patients with bilateral subthalamic nucleus (STN) deep brain stimulation underwent H(2)(15)O positron emission tomography (PET) imaging to measure regional cerebral blood flow (rCBF) while they performed kinematically matched sequence learning and movement tasks at baseline and during stimulation. Network analysis revealed a significant learning-related spatial covariance pattern characterized by consistent increases in subject expression during stimulation (p = 0.008, permutation test). The network was associated with increased activity in the lateral cerebellum, dorsal premotor cortex, and parahippocampal gyrus, with covarying reductions in the supplementary motor area (SMA) and orbitofrontal cortex. Stimulation-mediated increases in network activity correlated with concurrent improvement in learning performance (p < 0.02). To determine whether similar changes occurred during dopaminergic pharmacotherapy, we studied the subjects during an intravenous levodopa infusion titrated to achieve a motor response equivalent to stimulation. Despite consistent improvement in motor ratings during infusion, levodopa did not alter learning performance or network activity. Analysis of learning-related rCBF in network regions revealed improvement in baseline abnormalities with STN stimulation but not levodopa. These effects were most pronounced in the SMA. In this region, a consistent rCBF response to stimulation was observed across subjects and trials (p = 0.01), although the levodopa response was not significant. These findings link the cognitive treatment response in PD to changes in the activity of a specific cerebello-premotor cortical network. Selective modulation of overactive SMA-STN projection pathways may underlie the improvement in learning found with stimulation. (Keyword) Aged / Analysis of Variance / Brain Mapping / Cerebrovascular Circulation / Deep Brain Stimulation / Female / Humans / Learning Disorders / Male / Mental Recall / Middle Aged / Models, Biological / Neural Pathways / Neuropsychological Tests / Parkinson Disease / Positron-Emission Tomography / Reaction Time / Serial Learning / Severity of Illness Index / Subthalamic Nucleus (Link to Publication Site) ● Publication site (DOI): 10.1523/JNEUROSCI.4331-11.2012 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22357863 ● Search Scopus @ Elsevier (PMID): 22357863 ● Search Scopus @ Elsevier (DOI): 10.1523/JNEUROSCI.4331-11.2012 (DOI: 10.1523/JNEUROSCI.4331-11.2012, PubMed: 22357863)
39.	Hideo Mure, S Hirano, CC Tang, IU Isaias, A Antonini, Y Ma, V Dhawan and D Eidelberg : Parkinsons disease tremor-related metabolic network: Characterization, progression, and treatment effects, Neuroimage, Vol.54, No.2, 1244-1253, 2011. (Summary) The circuit changes that mediate parkinsonian tremor, while likely differing from those underlying akinesia and rigidity, are not precisely known. In this study, to identify a specific metabolic brain network associated with this disease manifestation, we used FDG PET to scan nine tremor dominant Parkinson's disease (PD) patients at baseline and during ventral intermediate (Vim) thalamic nucleus deep brain stimulation (DBS). Ordinal trends canonical variates analysis (OrT/CVA) was performed on the within-subject scan data to detect a significant spatial covariance pattern with consistent changes in subject expression during stimulation-mediated tremor suppression. The metabolic pattern was characterized by covarying increases in the activity of the cerebellum/dentate nucleus and primary motor cortex, and, to a less degree, the caudate/putamen. Vim stimulation resulted in consistent reductions in pattern expression (p<0.005, permutation test). In the absence of stimulation, pattern expression values (subject scores) correlated significantly (r=0.85, p<0.02) with concurrent accelerometric measurements of tremor amplitude. To validate this spatial covariance pattern as an objective network biomarker of PD tremor, we prospectively quantified its expression on an individual subject basis in independent PD populations. The resulting subject scores for this PD tremor-related pattern (PDTP) were found to exhibit: (1) excellent test-retest reproducibility (p<0.0001); (2) significant correlation with independent clinical ratings of tremor (r=0.54, p<0.001) but not akinesia-rigidity; and (3) significant elevations (p<0.02) in tremor dominant relative to atremulous PD patients. Following validation, we assessed the natural history of PDTP expression in early stage patients scanned longitudinally with FDG PET over a 4-year interval. Significant increases in PDTP expression (p<0.01) were evident in this cohort over time; rate of progression, however, was slower than for the PD-related akinesia/rigidity pattern (PDRP). We also determined whether PDTP expression is modulated by interventions specifically directed at parkinsonian tremor. While Vim DBS was associated with changes in PDTP (p<0.001) but not PDRP expression, subthalamic nucleus (STN) DBS reduced the activity of both networks (p<0.05). PDTP expression was suppressed more by Vim than by STN stimulation (p<0.05). These findings suggest that parkinsonian tremor is mediated by a distinct metabolic network involving primarily cerebello-thalamo-cortical pathways. Indeed, effective treatment of this symptom is associated with significant reduction in PDTP expression. Quantification of treatment-mediated changes in both PDTP and PDRP scores can provide an objective means of evaluating the differential effects of novel antiparkinsonian interventions on the different motor features of the disorder. (Keyword) Aged / Brain / Deep Brain Stimulation / Disease Progression / Female / Fluorodeoxyglucose F18 / Humans / Male / Middle Aged / Parkinson Disease / Positron-Emission Tomography / Radiopharmaceuticals / Tremor (Link to Publication Site) ● Publication site (DOI): 10.1016/j.neuroimage.2010.09.028 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20851193 ● Search Scopus @ Elsevier (PMID): 20851193 ● Search Scopus @ Elsevier (DOI): 10.1016/j.neuroimage.2010.09.028 (DOI: 10.1016/j.neuroimage.2010.09.028, PubMed: 20851193)
40.	Hideo Mure, Kazuhito Matsuzaki, KT Kitazato, Yoshifumi Mizobuchi, Kazuyuki Kuwayama, Teruyoshi Kageji and Shinji Nagahiro : Akt2 and Akt3 play a pivotal role in malignant gliomas, Neuro-Oncology, Vol.12, No.3, 221-232, 2010. (Summary) Akt, one of the major downstream effectors of phosphatidylinositol 3-kinase, is hyper-expressed and activated in a variety of cancers including glioblastoma. However, the expression profiles of the Akt isoforms Akt1/PKBalpha, Akt2/PKBbeta, and Akt3/PKBgamma and their functional roles in malignant glioma are not well understood. Therefore, we examined the protein and mRNA expression patterns of Akt isoforms in tissues from human astrocytomas, glioblastomas, and non-neoplastic regions. We also explored the biological role of each Akt isoform in malignant glioma cells using RNA interference-mediated knock-down and the over-expression of plasmid DNA of each isoform. The expression of Akt1 protein and mRNA was similar in glioma and normal control tissues. Although the protein and mRNA level of Akt2 increased with the pathological grade of malignancy, the expression of Akt3 mRNA and protein decreased as the malignancy grade increased. In U87MG, T98G, and TGB cells, the down-regulation of Akt2 or Akt3 by RNA interference reduced the expression of the phosphorylated form of Bad, resulting in the induction of caspase-dependent apoptosis. Akt1 knock-down did not affect cell growth or survival. We first demonstrate that the over-expression of Akt2 or Akt3 down-regulated the expression of the other protein and that endogenous Akt3 protein showed high kinase activity in U87MG cells. Our data suggest that Akt2 and Akt3 play an important role in the viability of human malignant glioma cells. Targeting Akt2 and Akt3 may hold promise for the treatment of patients with gliomas. (Keyword) apoptosis / Blotting, Western / Brain Neoplasms / cell separation / Flow Cytometry / gene expression / Gene Expression Profiling / Glioma / Humans / immunohistochemistry / Immunoprecipitation / In Situ Nick-End Labeling / Isoenzymes / Proto-Oncogene Proteins c-akt / RNA Interference / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction (Link to Publication Site) ● Publication site (DOI): 10.1093/neuonc/nop026 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20167810 ● Search Scopus @ Elsevier (PMID): 20167810 ● Search Scopus @ Elsevier (DOI): 10.1093/neuonc/nop026 (DOI: 10.1093/neuonc/nop026, PubMed: 20167810)
41.	Wataru Sako, Masanori Nishioka, Tomoyuki Maruo, Hideki Shimazu, Kazuhito Matsuzaki, Tetsuya Tamura, Hideo Mure, Yukitaka Ushio, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto : Subthalamic nucleus deep brain stimulation for camptocormia associated with Parkinson's disease, Movement Disorders, Vol.24, No.7, 1076-1079, 2009. (Summary) Camptocormia becomes increasingly recognized as a disabling symptom associated with Parkinson's disease (PD). We here report six patients with advanced PD in whom continuous bilateral stimulation of the subthalamic nucleus produced substantial (mean 78% +/- 9.1% of the thoracolumbar angle) improvement of camptocormia along with other motor symptoms. (Keyword) Adult / Deep Brain Stimulation / Female / Humans / Male / Middle Aged / Parkinson's disease / Postural Balance / Spinal Diseases / Subthalamic Nucleus (Link to Publication Site) ● Publication site (DOI): 10.1002/mds.22529 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19353719 ● Summary page in Scopus @ Elsevier: 2-s2.0-67651156100 (DOI: 10.1002/mds.22529, PubMed: 19353719, Elsevier: Scopus)
42.	Kazuyuki Kuwayama, Kazuhito Matsuzaki, Yoshifumi Mizobuchi, Hideo Mure, Keiko T. Kitazato, Teruyoshi Kageji, Michiyasu Nakao and Shinji Nagahiro : Promyelocytic leukemia protein induces apoptosis due to caspase-8 activation via the repression of NFkB activation in glioblastoma, Neuro-Oncology, Vol.11, No.2, 132-141, 2009. (Summary) Promyelocytic leukemia (PML) protein plays an essential role in the induction of apoptosis; its expression is reduced in various cancers. As the functional roles of PML in glioblastoma multiforme (GBM) have not been clarified, we assessed the expression of PML protein in GBM tissues and explored the mechanisms of PML-regulated cell death in GBM cells. We examined the PML mRNA level and the expression of PML protein in surgical GBM specimens. PML-regulated apoptotic mechanisms in GBM cells transfected with plasmids expressing the PML gene were examined. The protein expression of PML was significantly lower in GBM than in non-neoplastic tissues; approximately 10% of GBM tissues were PML-null. The PML mRNA levels were similar in both tissue types. The overexpression of PML activated caspase-8 and induced apoptosis in GBM cells. In these cells, PML decreased the expression of transactivated forms of NFkappaB/p65, and c-FLIP gene expression was suppressed. Therefore, PML-induced apoptosis resulted from the suppression of the transcriptional activity of NFkappaB/p65. PML overexpression decreased phosphorylated IkappaBalpha and nuclear NFkappaB/p65 and increased the expression of the suppressor of cytokine signaling (SOCS-1). A proteasome inhibitor blocked the reduction of activated p65 by PML. The reduction of PML is associated with the pathogenesis of GBM. PML induces caspase-8-dependent apoptosis via the repression of NFkappaB activation by which PML facilitates the proteasomal degradation of activated p65 and the sequestration of p65 with IkappaBalpha in the cytoplasm. This novel mechanism of PML-regulated apoptosis may represent a therapeutic target for GBM. (Keyword) apoptosis caspase, glioblastoma, NFkB/p65, promyelocytic leukemia (Link to Publication Site) ● Publication site (DOI): 10.1215/15228517-2008-083 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18812519 ● Search Scopus @ Elsevier (PMID): 18812519 ● Search Scopus @ Elsevier (DOI): 10.1215/15228517-2008-083 (DOI: 10.1215/15228517-2008-083, PubMed: 18812519)
43.	Wataru Sako, Satoshi Goto, Hideki Shimazu, Nagako Murase, Kazuhito Matsuzaki, Tetsuya Tamura, Hideo Mure, Yusuke Tomogane, Noriko Arita, Hiroo Yoshikawa, Shinji Nagahiro and Ryuji Kaji : Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia, Movement Disorders, Vol.23, No.13, 1929-1931, 2008. (Summary) Tardive dystonia is a disabling movement disorder as a consequence of exposure to neuroleptic drugs. We followed 6 patients with medically refractory tardive dystonia treated by bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for 21 +/- 18 months. At last follow-up, the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) motor score improved by 86% +/- 14%, and the BFMDRS disability score improved by 80% +/- 12%. Bilateral GPi-DBS is a beneficial therapeutic option for the long-term relief of tardive dystonia. (Keyword) Adult / Biophysics / Deep Brain Stimulation / Dystonia / Female / Globus Pallidus / Humans / Male / Middle Aged / Treatment Outcome (Link to Publication Site) ● Publication site (DOI): 10.1002/mds.22100 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18785227 ● Search Scopus @ Elsevier (PMID): 18785227 ● Search Scopus @ Elsevier (DOI): 10.1002/mds.22100 (DOI: 10.1002/mds.22100, PubMed: 18785227)
44.	Yoshifumi Mizobuchi, Kazuhito Matsuzaki, Kazuyuki Kuwayama, K Kitazato, Hideo Mure, Teruyoshi Kageji and Shinji Nagahiro : REIC/Dkk-3 induces cell death in human malignant glioma, Neuro-Oncology, Vol.10, No.3, 244-253, 2008. (Summary) The progression of glioma to more malignant phenotypes results from the stepwise accumulation of genetic alterations and the consequent disruption of the apoptotic pathway and augmentation of survival signaling. REIC/Dkk-3, a member of the human Dickkopf (Dkk) family, plays a role as a suppressor of the growth of several human cancers; however, to date it has not been identified in brain tumors. We compared the gene and protein expression of REIC/Dkk-3 in human malignant glioma and normal brain tissues using quantitative real-time PCR, Western blotting, and immunohistochemistry. We also performed small interfering REIC/Dkk-3 (siREIC/Dkk-3) knockdown and REIC/Dkk-3 overexpression experiments to examine the role of REIC/Dkk-3 in human malignant glioma cells in vitro. In brain tissue from patients with malignant glioma, the gene and protein expression of REIC/Dkk-3 was lower than in normal brain tissue and was related to the malignancy grade. In the primary glioblastoma cell line, REIC/Dkk-3 transfection led to apoptosis owing to the activation of phosphorylated JUN, caspase-9, and caspase-3 and the reduction of beta-catenin; in REIC/Dkk-3 knockdown experiments, cell growth was augmented. Our results suggest that REIC/Dkk-3 regulates the growth and survival of these cells in a caspase-dependent and -independent way via modification of the Wnt signaling pathway. Our work is the first documentation that the gene and protein expression of REIC/Dkk-3 is down-regulated in human malignant glioma. Our demonstration of the mechanisms underlying REIC/Dkk-3-induced cell death indicates that REIC/Dkk-3 plays a pivotal role in the biology of human malignant glioma and suggests that REIC/Dkk-3 is a promising candidate for molecular target therapy. (Keyword) Apoptosis / Blotting, Western / Brain Neoplasms / Cell Line, Tumor / Flow Cytometry / Fluorescent Antibody Technique / Gene Expression / Glioma / Humans / Immunohistochemistry / In Situ Nick-End Labeling / Intercellular Signaling Peptides and Proteins / Oligonucleotide Array Sequence Analysis / Protein Array Analysis / RNA, Small Interfering / Reverse Transcriptase Polymerase Chain Reaction / Signal Transduction / Transfection / beta Catenin (Link to Publication Site) ● Publication site (DOI): 10.1215/15228517-2008-016 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18443132 ● Search Scopus @ Elsevier (PMID): 18443132 ● Search Scopus @ Elsevier (DOI): 10.1215/15228517-2008-016 (DOI: 10.1215/15228517-2008-016, PubMed: 18443132)
45.	Hideo Mure, Kazuyuki Kuwayama, Junichiro Satomi, Koichi Satoh and Shinji Nagahiro : 痴呆症状で発症し治療に難渋したテント部硬膜動静脈瘻の2例, Surgery for Cerebral Stroke, Vol.33, No.4, 273-278, 2005. (Link to Publication Site) ● Publication site (DOI): 10.2335/scs.33.273 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.2335/scs.33.273 (DOI: 10.2335/scs.33.273)
46.	阿川昌仁, Hideo Mure, Kenji Yagi and 津田敏雄 : 閉塞性脳血管障害患者に対する血行再建術前後の頸動脈超音波，SPECT，高次脳機能所見, Neurosonology, Vol.14, 95-99, 2001.

Academic Paper (Unrefereed Paper):

1.	小山広士, Shinya Ohkita, Hideo Mure, Ryoma Morigaki, Ryuji Kaji, Satoshi Goto and Shinji Nagahiro : 症例報告第17回若手奨励賞受賞論文遅発性ジストニア(tardive dystonia)に対して脳深部刺激術を施行した5例, Shikoku Acta Medica, Vol.73, No.3 4, 193-196, 2017. (Summary) We assessed the efficiency of pallidal deep brain stimulation for tardive dystonia. This search was carried out in Electronic chart of Tokushima University Hospital. 5 patients with tardive dystonia were enrolled. GPi(internal segment of globus pallidus)was the target in all patients. The motor part of Burke-Fahn-Marsden Dystonia Rating Scale(BFMDRS)was improved by 78．4% on average when compared to preoperative BFMDRS scores. The performed analysis indicates that GPi-DBS is an effective and safe treatment for tardive dystonia. (Keyword) deep brain stimulation / globus pallidus internus / tardive dyskinesia / tardive syndrome / Burke-Fahn-Marsden dystonia rating scale(BFMDRS) (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050865122807275264 (CiNii: 1050865122807275264)
2.	Yoshiteru Tada, Motohiro Hirasawa, Hideo Mure, Junichiro Satomi, 山本信昭 and Takashi Abe : T2強調画像で脊髄内に高信号を呈する病変, Practical Currently, Vol.24, No.11, 1194-1197, 2014.
3.	Hideo Mure, 稲垣徹, 入江伸介, 酒井淳, 近藤史郎, 大坂美鈴 and 齋藤孝次 : IMP 定量方による追跡調査について-脳主幹動脈閉塞・狭窄症の非手術症例-, 第14回北海道脳PET・SPECT 研究会記録集, No.14, 2006.

Academic Letter:

1.	Ryoma Morigaki, Masahito Nakataki, Toshitaka Kawarai, Lillian V. Lee, Rosalia A. Teleg, Ma Daisy P. Tabuena, Hideo Mure, Wataru Sako, Paul Matthew D. Pasco, Shinji Nagahiro, Junichi Iga, Tetsuro Ohmori, Satoshi Goto and Ryuji Kaji : Depression in X-linked dystonia-parkinsonism:A case-control study, Parkinsonism & Related Disorders, Vol.19, No.9, 844-846, 2013. (Keyword) Case-Control Studies / Depression / Dystonic Disorders / Genetic Diseases, X-Linked / Heredodegenerative Disorders, Nervous System / Humans / Male / Parkinson Disease (Link to Publication Site) ● Publication site (DOI): 10.1016/j.parkreldis.2013.04.027 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23706616 ● Summary page in Scopus @ Elsevier: 2-s2.0-84880785140 (DOI: 10.1016/j.parkreldis.2013.04.027, PubMed: 23706616, Elsevier: Scopus)

Proceeding of International Conference:

1.	Joji Fujikawa, Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama, Teruo Oda, Nobuaki Yamamoto, Yuishin Izumi, Hideo Mure, Satoshi Goto and Yasushi Takagi : Cranial geometry in patients with dystonia, The 13th Scientific meeting of Asian Australasian Society for Stereotactic and Functional Neurosurgery (AASSFN 2023), Osaka, Apr. 2023.
2.	Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Kazuhisa Miyake, Taku Matsuda, Hiroshi Koyama and Yasushi Takagi : Long-term follow-up of 12 patients treated with bilateral pallidal stimulation for tardive dystonia, 13th Scientific meeting of Asian Australasian Society for Streotactic and Functional Neurosurgery, Osaka, Apr. 2023.
3.	Ryoma Morigaki, S Okita, Hideo Mure, Yasushi Takagi and S Goto : Olfactory type g-protein alfa subunit related changes in the striatum underlie the genesis of L-DOPA induced dyskinesiaBrain and Brain PET2019, Brain and Brain PET2019, Jul. 2019.
4.	Ryoma Morigaki, Shinya Ohkita, Hideo Mure, Yasushi Takagi and Satoshi Goto : Olfactory type G-protein alfa subunit related changes in the striatum underlie the genesis of L-dopa-induced dyskinesia, Journal of Cerebral Blood Flow and Metabolism, Yokohama, Jun. 2019.
5.	Kenji Shono, Izumi Yamaguchi, Toshitaka Fujihara, Keiko Kitazato, Kohhei Nakajima, Yoshifumi Mizobuchi, Hideo Mure, Kohhei Nakajima, Junichiro Satomi, Shinji Nagahiro and Yasushi Takagi : Celecoxib inhibits proliferation and induces apoptosis in glioma stem cells and an animal model of glioblastoma., 22ND ANNUAL SCIENTIFIC MEETING AND EDUCATION DAY OF THE SOCIETY FOR NEURO-ONCOLOGY, San Francisco, Nov. 2017.
6.	Junichiro Satomi, Yasuhisa Kanematsu, Masaaki Korai, Yuki Yamamoto, Nobuaki Yamamoto, Yoshifumi Mizobuchi, Hideo Mure, Yoshiteru Tada, Kohhei Nakajima, Toshiyuki Okazaki and Toshitaka Fujihara : Acute stroke management using image sharing on smart phones and tablet devices, 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY, Budapest, Oct. 2017.
7.	Hideo Mure, Ryoma Morigaki, Shinya Ohkita, Ryosuke Miyamoto, Shinji Nagahiro and Satoshi Goto : Deep Brain Stimulation for Dystonia - Pallidal stimulation and thalamic stimulation, World Society for Stereotactic and Functional Neurosurgery, Berlin, Jun. 2017.
8.	Toshitaka Kawarai, Ryosuke Miyamoto, Hideo Mure, Ryoma Morigaki, Orlacchio Antonio, Koichihara Reiko, Nakagawa Eiji, Takashi Sakamoto, Yuishin Izumi, Satoshi Goto and Ryuji Kaji : Haploinsufficiency of KMT2B causes myoclonus-dystonia with impaired psychomotor ability, The MDS 21th International Congress of Parkinsons Disease and Movement Disorders, Jun. 2017. (Keyword) KMT2B / dystonia
9.	Junichiro Satomi, Yoshiteru Tada, Yasuhisa Kanematsu, Kazuyuki Kuwayama, Kenji Yagi, Tomoya Kinouchi, Kohhei Nakajima, Nobuhisa Matsushita, Takeshi Miyamoto, Tadashi Yamaguchi, Masaaki Korai, Hideo Mure, Keiko Kitazato and Shinji Nagahiro : A Pilot Study of the Mineralocorticoid Receptor Blocker Eplerenone in Hypertensive Patients with Unruptured Cerebral Aneurysms, International Stroke Conference 2016, Los Angeles, Feb. 2016.
10.	Kenji Shouno, Teruyoshi Kageji, Yoshifumi Mizobuchi, Toshitaka Fujihara, Keiko T Kitazato, Kohhei Nakajima, Hideo Mure, Kazuyuki Kuwayama and Shinji Nagahiro : Sonodynamic 5-ALA plus ultrasound therapy augments anti-tumor effects in the oncogene knock-in glioma stemcells, 20th Annual Socientific Meeting and Education Day of the Society for Neuro-Oncology, Nov. 2015.
11.	Toshitaka Fujihara, Teruyoshi Kageji, Yoshifumi Mizobuchi, Keijiro Hara, Kenji Shouno, Kohhei Nakajima, Hideo Mure, Kazuyuki Kuwayama and Shinji Nagahiro : Down-regulation of MDR1 by DKK3 attenuates chemoresistance to temozolomide, and potentiates its anti-tumor effects, 20th Annual Socientific Meeting and Education Day of the Society for Neuro-Oncology, Nov. 2015.
12.	Hideo Mure : Deep brain stimulation of the thalamic ventral lateral anterior nucleus for DYT6 dystonia, WSSFN INTERIM MEETING2015, Sep. 2015. (Link to Publication Site) ● Publication site (DOI): 10.1159/000365577 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25359437 ● Summary page in Scopus @ Elsevier: 2-s2.0-84910089742 (DOI: 10.1159/000365577, PubMed: 25359437, Elsevier: Scopus)
13.	Hideo Mure, C.C. Tang, S Hirano and Shinji Nagahiro : Identification and validation of a Parkinsons disease tremor-related metabolic network, 18th International Congress of Parkinsons Disease and Movement Disorders, Stockholm, Jun. 2014.
14.	Yoshifumi Mizobuchi, T Okazaki, Teruyoshi Kageji, Kazuyuki Kuwayama, KT Kitazato, Hideo Mure, Keijiro Hara, Ryoma Morigaki, Kazuhito Matsuzaki, Kohhei Nakajima, T Fujihara and Shinji Nagahiro : A combination of interferon-beta and temozolomide augments anti-tumor effects through p73/YAP-mediated apoptosis by PML in glioblastoma, The 4th Quadrennial Meeting of the World Federation of Neuro-Oncology held in conjunction with the 2013 SNO Scientific Meeting and Education Day, San Francisco, Nov. 2013.
15.	Keijiro Hara, Teruyoshi Kageji, Yoshifumi Mizobuchi, T Okazaki, T Fujihara, Kohhei Nakajima, Hideo Mure, Kazuyuki Kuwayama, T Hara and Shinji Nagahiro : REIC/Dkk-3, one of Dickkopf(Dkk)family members, contributes to the anti-tumor effects in glioblastoma through regulation of both Wnt signal pathways, The 4th Quadrennial Meeting of the World Federation of Neuro-Oncology held in conjunction with the 2013 SNO Scientific Meeting and Education Day, San Francisco, Nov. 2013.
16.	Hideo Mure, CC Tang, A Miklos, Shinji Nagahiro and D Eidelberg : Improved sequence learning with STN deep brain stimulation: Evidence for treatment-specific network modulation, 17th International Congress of Parkinsons Disease and Movement Disorders, Sydney, Jun. 2013.
17.	Yoshifumi Mizobuchi, Kazuhito Matsuzaki, Teruyoshi Kageji, Keiko T. Kitazato, Hideo Mure, Kazuyuki Kuwayama, Toshiyuki Okazaki, A. Manno, T. Matsuda and Shinji Nagahiro : REIC/Dkk-3 Gene and protein Regulate Medulloblastoma Cell Growth, 2012American Association of Neurological Surgeons Annual Scientific Meeting, Miami, Apr. 2012.
18.	Yoshifumi Mizobuchi, Kazuhito Matsuzaki, KT Kitazato, Hideo Mure, Teruyoshi Kageji and Shinji Nagahiro : Silencing LRP6 induces cell death in human malignant glioma, XIV World Congress of Neurological Surgery, Boston, Aug. 2009.
19.	Yoshifumi Mizobuchi, Kazuhito Matsuzaki, Kazuyuki Kuwayama, KT Kitazato, Hideo Mure, Teruyoshi Kageji and Shinji Nagahiro : REIC/Dkk-3 induces cell death in human malignant glioma, Society for Neuro-Oncology 13th Annual Scientific Meeting & Education Day, Las Vegas, Nov. 2008.
20.	Kazuhito Matsuzaki, Kazuyuki Kuwayama, Yoshifumi Mizobuchi, Hideo Mure, KT Kitazato, Teruyoshi Kageji and Shinji Nagahiro : Promyelocytic leukemia protein induces apoptosis by the repression of NFkB activation in glioblastoma cells, Society for Neuro-Oncology 13th Annual Scientific Meeting & Education Day, Las Vegas, Nov. 2008.
21.	Hideo Mure, Kazuhito Matsuzaki, KT Kitazato, Yoshifumi Mizobuchi, Kazuyuki Kuwayama, Teruyoshi Kageji and Shinji Nagahiro : Functional role of akt isoforms in human malignant gliomas, Society for Neuro-Oncology 13th Annual Scientific Meeting & Education Day, Las Vegas, Nov. 2008.
22.	Kazuhito Matsuzaki, S Uyama, KT Kitazato, Kazuyuki Kuwayama, Yoshifumi Mizobuchi, Hideo Mure, Teruyoshi Kageji and Shinji Nagahiro : Down-regulation of Akt1 and Akt2 by RNA interference enhances the anti-tumor effects of radiation on malignant glioma cells, 2007 Congress of Neurological Surgeons Annual Meeting, San Diego, Sep. 2007.
23.	Yoshifumi Mizobuchi, Kazuhito Matsuzaki, Kazuyuki Kuwayama, KT Kitazato, Hideo Mure, Teruyoshi Kageji and Shinji Nagahiro : REIC/Dkk-3 induces cell death in human malignant glioma, 2007 Congress of Neurological Surgeons Annual Meeting, San Diego, Sep. 2007.

Proceeding of Domestic Conference:

1.	Kazuhisa Miyake, Ryoma Morigaki, Hideo Mure, Taku Matsuda, Satoshi Goto and Yasushi Takagi : Vo-DBS施行後から9年経過したDYT6ジストニア患者の長期予後, 日本定位・機能神経外科学会機関紙, Jan. 2022.
2.	Taku Matsuda, Ryoma Morigaki, Yuki Matsumoto, Hideo Mure, Kazuhisa Miyake, Masahito Nakataki, Masafumi Harada and Yasushi Takagi : 全身性ジストニアと強迫性障害の重症度についての検討, 日本定位・機能神経外科学会機関紙, Jan. 2022.
3.	Ryoma Morigaki, Joji Fujikawa, Taku Matsuda, Kazuhisa Miyake, Hideo Mure, Teruo Oda, Ryosuke Miyamoto, Koji Fujita, Nobuaki Yamamoto, 和泉唯心 and Yasushi Takagi : 特発性ジストニア患者の頭蓋骨の歪み, 日本定位・機能神経外科学会機関紙, Jan. 2022.
4.	Taku Matsuda, Ryoma Morigaki, Yuki Matsumoto, Hideo Mure, Kazuhisa Miyake, Masahito Nakataki, Masafumi Harada and Yasushi Takagi : 全身性ジストニアと強迫性障害の重症度についての検討, 第61回日本定位・機能神経外科学会, Jan. 2022.
5.	Taku Matsuda, Ryoma Morigaki, Yuki Matsumoto, Hideo Mure, Kazuhisa Miyake, Masahito Nakataki and Yasushi Takagi : 全身性ジストニアの重症度と強迫観念の関係性についての検討, 日本脳神経外科学会学術総会, Oct. 2021.
6.	Kazuhisa Miyake, Ryoma Morigaki, Hideo Mure and Yasushi Takagi : DYT6ジストニア患者におけるDBS術後9年の長期予後, 日本脳神経外科学会学術総会, Oct. 2021.
7.	Mai Azumi, Hideo Mure and Yasushi Takagi : 広範な硬膜欠損に対して吸収性コラーゲン人工硬膜を用いて髄液漏を防ぎ得た脊髄髄膜瘤の1例, 第49回日本小児神経外科学会, Jun. 2021.
8.	Ryoma Morigaki, Hideo Mure, Taku Matsuda, Kazuhisa Miyake, Ryosuke Miyamoto, Koji Fujita, Masahito Nakataki, Ryuji Kaji, Yasushi Takagi and Satoshi Goto : 機能ー器質ボーダーラインジストニアに対する脳深部刺激療法, 第60回日本定位・機能神経外科学会, Jan. 2021.
9.	Hideo Mure, Ryoma Morigaki, 小山広士, Kazuhisa Miyake, Taku Matsuda, Ryosuke Miyamoto, Koji Fujita, Yuishin Izumi, Satoshi Goto and Yasushi Takagi : 遅発性ジストニアに対する淡蒼球内節刺激術12例の検討ー適応・長期成績・刺激条件についてー, 第60回日本定位・機能神経外科学会, Jan. 2021.
10.	Kazuhisa Miyake, Taku Matsuda, Ryoma Morigaki, Hideo Mure, Yasushi Takagi and Ryosuke Miyamoto : ジストニックストームを生じたGNAO1遺伝子変異に対し淡蒼球脳深部刺激療法を行った1例, 第60回日本定位・機能神経外科学会, Jan. 2021.
11.	Hideo Mure, Ryoma Morigaki, 小山広士, Shinya Ohkita, Taku Matsuda, Wataru Sako, Ryosuke Miyamoto, Koji Fujita, Yuishin Izumi, Ryuji Kaji, Satoshi Goto and Yasushi Takagi : 遅発性ジストニアに対する淡蒼球内節刺激術12例の検討:適応・長期成績・刺激条件について, 第79回日本脳神経外科学会総会, Oct. 2020.
12.	Ryosuke Miyamoto, 黒田一駿, Hideo Mure, Ryoma Morigaki, Masahito Nakataki, Yusuke Osaki, Yuishin Izumi, Satoshi Goto and Ryuji Kaji : 18p-症候群に伴う全身性ジストニアに対し，GPi-DBSが効果的であった一例, 第61回日本神経学会学術大会, Aug. 2020.
13.	Taku Matsuda, Ryoma Morigaki, Hideo Mure, Masahito Nakataki, 山本陽子, 豊田直人, Satoshi Goto and Yasushi Takagi : ジストニアと強迫性障害の関係についての検討, Functional Neurosurgery, 130, Jan. 2020.
14.	Hideo Mure, Koji Fujita, Ryoma Morigaki, Ryosuke Miyamoto, 松田拓, Satoshi Goto, Yasushi Takagi and Satoshi Goto : FDG PETを用いたジストニア患者の脳代謝ネットワークパターンの描出, Functional Neurosurgery, 132, Jan. 2020.
15.	Ryoma Morigaki, Hideo Mure, Taku Matsuda, Ryosuke Miyamoto, 山本陽子, 豊田直人, Yasushi Takagi and Satoshi Goto : GPi-DBSを施行したDYT-GNAL(DYT25)の一例, Functional Neurosurgery, 134, Jan. 2020.
16.	Ryosuke Miyamoto, Koji Fujita, Hideo Mure, Ryoma Morigaki, Masahito Nakataki, Yuishin Izumi, Satoshi Goto and Ryuji Kaji : ヒステリー性麻痺の臨床診断と電気生理心因性運動障害の診断心因性ジストニアを中心に, 第49回日本臨床神経生理学会学術大会, Nov. 2019.
17.	Yuki Yamamoto, Nobuaki Yamamoto, Yasuhisa Kanematsu, Manabu Ishihara, Takeshi Miyamoto, Masaaki Korai, Kenji Shimada, Hideo Mure, Yasushi Takagi and Yuishin Izumi : 転倒後の脳脊髄液減少症に上矢状静脈洞血栓症を合併し, 血管内治療をおこなった一例, 第35回日本脳神経血管内治療学会学術総会, Nov. 2019.
18.	Yuki Yamamoto, Nobuaki Yamamoto, 福本竜也, 村上永久, Ryosuke Miyamoto, Koji Fujita, Hideo Mure, Yasuhisa Kanematsu, Yasushi Takagi and Yuishin Izumi : 転倒を契機に脳脊髄液減少症と静脈洞血栓症を合併し，ブラッドパッチにて治療した脊髄小脳変性症6型の1例, 第37回日本神経治療学会学術集会, Nov. 2019.
19.	Ryoma Morigaki, Hideo Mure, Ryosuke Miyamoto, Taku Matsuda, 山本陽子, Yasushi Takagi and Satoshi Goto : 機能性ジストニアは器質性ジストニアスペクトラム障害か?, Neurologia Medico-Chirurgica, 349, Oct. 2019.
20.	Hideo Mure, Koji Fujita, Ryoma Morigaki, Ryosuke Miyamoto, Satoshi Goto and Yasushi Takagi : FDG PETを用いたジストニア患者の脳代謝ネットワークパターンの描出, 日本脳神経外科学会第78回学術集会, Oct. 2019.
21.	Masaaki Korai, Junichiro Satomi, Yasuhisa Kanematsu, Hideo Mure, Kenji Shimada, Toshiyuki Okazaki and Yasushi Takagi : 硬膜動静脈瘻に対する直達術, 日本脳神経外科学会第77回学術総会, Oct. 2018.
22.	Hideo Mure, Ryosuke Miyamoto, Shinya Ohkita, Ryuji Kaji, Satoshi Goto, Shinji Nagahiro and Yasushi Takagi : 小児期ジストニアに対する脳深部刺激療法の適応と予後について, 日本脳神経外科学会第77回学術総会, Oct. 2018.
23.	Toshitaka Fujihara, Yoshifumi Mizobuchi, Kohhei Nakajima, Toshiyuki Okazaki, Hideo Mure and Yasushi Takagi : 膠芽腫におけるDKK3遺伝子導入による薬剤排泄ポンプの発現抑制の意義, 日本脳神経外科学会第77回学術総会, Oct. 2018.
24.	Hideo Mure, Toshiyuki Okazaki and Yasushi Takagi : パーキンソン病患者の腰痛に対する脊髄刺激療法の長期成績, 第33回日本脊髄外科学会, Jun. 2018.
25.	Tatsuya Haboshi, Masaaki Korai, Hideo Mure, Yasuhisa Kanematsu, Junichiro Satomi and Yasushi Takagi : 頭蓋内出血で発症した蝶形骨小翼部硬膜動静脈瘻の1例, 第85回日本脳神経外科学会中国四国支部学術集会, Apr. 2018.
26.	Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Masahito Nakataki, Yasushi Takagi, Ryuji Kaji, Shinji Nagahiro and Satoshi Goto : ジストニアDBS治療における多職種連携．, 第57回日本定位・機能神経外科学会, Jan. 2018.
27.	Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Masahito Nakataki, 岡久哲也, Yasushi Takagi, Ryuji Kaji, Shinji Nagahiro and Satoshi Goto : ジストニアDBS治療における多職種連携, 第57回日本定位・機能神経外科学会, Jan. 2018.
28.	Toshitaka Fujihara, Yoshiteru Tada, Kohhei Nakajima, Hideo Mure, Masafumi Harada, Junichiro Satomi and Shinji Nagahiro : 非痙攣性てんかん重積診断におけるArterial Spin Labeling法の有用性, 第51回日本てんかん学会年次学術集会, Nov. 2017.
29.	Toshitaka Fujihara, Yoshiteru Tada, Kohhei Nakajima, Hideo Mure, Masafumi Harada, Junichiro Satomi and Shinji Nagahiro : 当院で経験した非痙攣性てんかん重積症例の検討, 日本脳神経外科学会第76回学術総会, Oct. 2017.
30.	Hideo Mure, Ryoma Morigaki, Ryosuke Miyamoto, Masahito Nakataki, Junichiro Satomi, Ryuji Kaji, Satoshi Goto and Shinji Nagahiro : ジストニアDBS治療におけるチーム医療の重要性 -徳島大学での取り組み-, 日本脳神経外科学会第76回学術総会, Oct. 2017.
31.	Ryoma Morigaki, Shinya Ohkita, Hideo Mure, Shinji Nagahiro and Satoshi Goto : L-ドーパ誘発性ジスキネジア発症におけるGαolf発現の変化, 日本脳神経外科学会第76回学術総会, Oct. 2017.
32.	Hideo Mure, 榎本紀哉, Shinya Ohkita and Shinji Nagahiro : C2神経根起始部に髄膜憩室を認めた脳脊髄液漏出症の一例, 第32回日本脊髄外科学会, Jun. 2017.
33.	亘雄也, Hideo Mure, Ryoma Morigaki, Shinya Ohkita, 西山徹 and Shinji Nagahiro : Lance-Adams症候群に対する両側淡蒼球内節刺激術の一施行例, 第83回日本脳神経外科学会中国四国支部学術集会, Apr. 2017.
34.	Toshitaka Fujihara, Yoshiteru Tada, Kohhei Nakajima, Hideo Mure, 飯田幸治 and Shinji Nagahiro : 同側の未破裂中大脳動脈瘤を合併した左海馬硬化症による難治性内側側頭葉てんかんの一例, 第11回てんかん学会中国・四国地方会, Feb. 2017.
35.	藤原敏孝, Kohhei Nakajima, Hideo Mure, 飯田幸治 and Shinji Nagahiro : 同側の未破裂中大脳動脈瘤を合併した左海馬硬化症による難治性内側側頭葉てんかんの一例, 第40回日本てんかん外科学会, Jan. 2017.
36.	榎本紀哉, Hideo Mure, Shinya Ohkita, Junichiro Satomi and Shinji Nagahiro : C2神経根起始部にmeningeal diverticulium を認めた脳脊髄駅漏出症の1例, 第82回日本脳神経外科学会中四国支部学術集会, Dec. 2016.
37.	藤原敏孝, Yoshiteru Tada, Kohhei Nakajima, Hideo Mure, Junichiro Satomi, Masafumi Harada and Shinji Nagahiro : Stroke Care Unitでのてんかん診断-Arterial Spin Labeling法の有用性, 第32回NPO法人日本脳神経血管内治療学会学術総会, Nov. 2016.
38.	藤原敏孝, Yoshiteru Tada, Kohhei Nakajima, Hideo Mure, Junichiro Satomi, Masafumi Harada and Shinji Nagahiro : Stroke Care Unitでのてんかん診断-Arterial Spin Labeling法の有用性, 第50回日本てんかん学会学術集会, Oct. 2016.
39.	藤原敏孝, Yoshiteru Tada, Kohhei Nakajima, Hideo Mure, Junichiro Satomi, Masafumi Harada and Shinji Nagahiro : Stroke Care Unitでのてんかん診断-Arterial Spin Labeling法の有用性, 日本脳神経外科学会第75回学術総会, Sep. 2016.
40.	Yoshiteru Tada, Yasuhisa Kanematsu, Junichiro Satomi, Kazuyuki Kuwayama, Kenji Yagi, Tomoya Kinouchi, Kohhei Nakajima, Masaaki Korai, Hideo Mure, Takeshi Miyamoto, 山口真司, 北里慶子 and Shinji Nagahiro : 高血圧症合併未破裂脳動脈瘤に対するミネラルコンチコイド受容体阻害薬の有効性に関するパイロット試験, 日本脳神経外科学会第75回学術総会, Sep. 2016.
41.	日岡明美, Yoshifumi Mizobuchi, 中村和己, Yoshiteru Tada, Hideo Mure, Kyoko Nishi, 北里慶子, Junichiro Satomi and Shinji Nagahiro : 年代別健常者の高次脳機能障害スクリーニングテストの特性, 第17回日本早期認知症学会学術集会, Sep. 2016.
42.	Hideo Mure, Shinya Ohkita, Ryoma Morigaki, Satoshi Goto and Shinji Nagahiro : 小児ジストニアに対する脳深部刺激療法の経験, 第21回四国脳神経外科カンファレンス, Aug. 2016.
43.	Kenji Yagi, 中川洋, Hideo Mure and Shinji Nagahiro : 下位腰椎の椎間孔内外側に進展した黄色靭帯骨化症の1例, 第31回日本脊髄外科学会, Jun. 2016.
44.	Hideo Mure, 羽星辰哉 and Shinji Nagahiro : 原因不明の胸髄脊髄空洞症に対する一治療の経験, 第31回日本脊髄外科学会, Jun. 2016.
45.	Hideo Mure, Shinya Ohkita and Nobuaki Yamamoto : 変形性脊椎症と特発性正常圧水頭症の合併例の検討, 第17回日本正常圧水頭症学会, Mar. 2016.
46.	Shinya Ohkita, Ryoma Morigaki, Hideo Mure, Yasuhisa Kanematsu, 宮本亮介, Shinji Nagahiro, Ryuji Kaji, Satoshi Goto, 亘雄也, 谷口秀和, 夫敬憲 and 中川義信 : 脳性麻痺に合併した全身性ジストニアに対し脳深部刺激術を施行した1例, 第55回日本定位・機能神経外科学会, Jan. 2016.
47.	Hideo Mure, Ryoma Morigaki, Shinya Ohkita, 小泉英期, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto : ジストニアに対するDBS-淡蒼球刺激と視床刺激の併用-, 第55回日本定位・機能神経外科学会, Jan. 2016.
48.	Ryoma Morigaki, 宮本亮介, Shinya Ohkita, Yoshifumi Mizobuchi, Hideo Mure, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto : Distribution patterns and functional roles of nuclear factor kappa b in the mouse striatum, 第55回日本定位・機能神経外科学会, Jan. 2016.
49.	Ryoma Morigaki, Shinya Ohkita, Hideo Mure, Yoshifumi Mizobuchi, Satoshi Goto, Ryuji Kaji and Shinji Nagahiro : Nuclear factor kappa bはマウス脳線条体においてドパミンシグナル支配下に機能する, 一般社団法人日本脳神経外科学会第74回学術総会, Oct. 2015.
50.	Hideo Mure, Ryoma Morigaki, Shinya Ohkita, Ryuji Kaji, Wataru Sako, Satoshi Goto and Shinji Nagahiro : Meige症候群に対する両側淡蒼球内節刺激術, 一般社団法人日本脳神経外科学会第74回学術総会, Oct. 2015.
51.	Ryoma Morigaki, Shinya Ohkita, Yoshifumi Mizobuchi, Hideo Mure, Shinji Nagahiro, Ryuji Kaji and Satoshi Goto : マウス脳線条体におけるNuclear factor kappa bの機能的分子としての可能性, 第16回日本分子脳神経外科学会, Aug. 2015.
52.	Hideo Mure, Kenji Yagi, Shinji Nagahiro, Kenji Shimada and Kousaku Higashino : 引き抜き損傷後17年後に発症した脊髄くも膜嚢胞の一例, 第30回日本脊髄外科学会, Jun. 2015.
53.	Toshitaka Kawarai, Ryosuke Miyamoto, Tamura Asako, Takashi Abe, Funakoshi Yasuhiro, Orlacchio Antonio, Oki Ryosuke, Hideo Mure, Ryoma Morigaki, Satoshi Goto, Yuishin Izumi, Naito Hiroshi, Tomimoto Hidekazu and Ryuji Kaji : Germline mosaicism of TUBB4A mutation causes dystonia in two siblings., 56th Annual Meeting of the Japanese Society of Neurology, May 2015.
54.	Shinya Ohkita, Ryoma Morigaki, Hideo Mure, 松田拓, Shinji Nagahiro, Satoshi Goto and Ryuji Kaji : Hypomyelination with atrophy of the basal ganglia and cerebellumに対し脳深部刺激術を施行した1例, 第54回日本定位・機能神経外科学会, Jan. 2015.
55.	Hideo Mure, Shinya Ohkita, Shinji Nagahiro, Ryoma Morigaki, Satoshi Goto, Wataru Sako and Ryuji Kaji : Meige症候群に対するGPi-DBS, 第54回日本定位・機能神経外科学会, Jan. 2015.
56.	Hideo Mure, Ryoma Morigaki, Shinya Ohkita, Shinji Nagahiro, Kazuhito Matsuzaki and Satoshi Goto : ジストニアに対するDBS-淡蒼球刺激と視床刺激の併用-, 第73回日本脳神経外科学会学術総会, Oct. 2014.
57.	Hideo Mure, 山口真司, Shinji Nagahiro and Motohiro Hirasawa : 神経膠芽腫脊髄播種による難治性疼痛に対してSCSを施行した1例, 第29回日本脊髄外科学会, Jun. 2014.
58.	Motohiro Hirasawa and Hideo Mure : 膠芽腫脊髄播種による難治性下肢痛に対しSCSが有効であった1例, 第10回Neuro Spinalセミナー, Feb. 2014.
59.	Motohiro Hirasawa, Hideo Mure and Shinji Nagahiro : 成人発症tethered cord syndromeの3症例, Authentic Spinal Surgeon Summit 2014, Feb. 2014.
60.	大北真哉, Hideo Mure, Yoshifumi Mizobuchi, Shinji Nagahiro, Ryoma Morigaki, Satoshi Goto, 宮本亮介, 山本伸昭 and Ryuji Kaji : 高インスリン血性高アンモニア血性症候群に合併した全身性ジストニアに対し，脳深部刺激術を施行した1例, 第53回日本定位・機能神経外科学会, Feb. 2014.
61.	Ryoma Morigaki, 小泉英貴, Hideo Mure, 大北真哉, Yoshifumi Mizobuchi, Shinji Nagahiro, Ryuji Kaji, Satoshi Goto and Toshitaka Kawarai : X-linked dystonia-parkinsonismのニューロペプタイドYシステム, 第53回日本定位・機能神経外科学会, Feb. 2014.
62.	Hideo Mure, Ryoma Morigaki, 大北真哉, Shinji Nagahiro, Satoshi Goto, 小泉英貴 and Ryuji Kaji : ジストニックストームにおける治療法の検討-4例の自験例と文献的考察-, 第53回日本定位・機能神経外科学会, Feb. 2014.
63.	Hideo Mure : 当科における顕微鏡下手根管開放術, 第9回NEURO spinalセミナー, Jul. 2013.
64.	Hideo Mure : 徳島大学におけるDBS治療の現状, 第62回徳島神経疾患症例研究会-西部地区-, Jul. 2013.
65.	庄野健児, Hideo Mure, Motohiro Hirasawa and Shinji Nagahiro : 術中蛍光造影が有効であった神経サルコイドーシスの1例, 第28回日本脊髄外科学会, Jun. 2013.
66.	Hideo Mure, Motohiro Hirasawa and Shinji Nagahiro : ケージを用いた頚椎前方固定術における骨癒合の検討, 第28回日本脊髄外科学会, Jun. 2013.
67.	Motohiro Hirasawa, Hideo Mure and Shinji Nagahiro : リン酸カルシウムペーストを用いた腰椎椎体間固定術の治療成績, 第28回日本脊髄外科学会, Jun. 2013.
68.	Hideo Mure, Motohiro Hirasawa and Shinji Nagahiro : 難治性疼痛に対する脊髄刺激療法の経験, 第28回日本脊髄外科学会, Jun. 2013.
69.	Motohiro Hirasawa, Hideo Mure and Shinji Nagahiro : 脊髄疾患由来の痙縮に対するバクロフェン髄注療法の経験, 第28回日本脊髄外科学会, Jun. 2013.
70.	Hideo Mure, Kohhei Nakajima, Motohiro Hirasawa, Shinji Nagahiro, 小泉英貴 and Ryuji Kaji : パーキンソン病に合併した腰痛に対する脊髄刺激療法の1例，, 第1回徳島脳神経疾患談話会, Mar. 2013.
71.	庄野健児, Motohiro Hirasawa, Hideo Mure and Shinji Nagahiro : 術中蛍光造影が生検に有用であった脊髄サルコイドーシスの1例, 第8回ニューロスパイナルセミナー, Jan. 2013.
72.	Ryoma Morigaki, Masahito Nakataki, Junichi Iga, Toshitaka Kawarai, Hideo Mure, Yoshifumi Mizobuchi, 大北真哉, Tetsuro Ohmori, Shinji Nagahiro, Satoshi Goto and Ryuji Kaji : X-linked dystonia-parkinsonismのうつ症状, 第52回日本定位・機能神経外科学会, Jan. 2013.
73.	Hideo Mure, Ryoma Morigaki, 大北真哉, Satoshi Goto, Shinji Nagahiro, 小泉英貴, Toshitaka Kawarai and Ryuji Kaji : 両側視床Vo核刺激が奏功したDYT6の一例, 第52回日本定位・機能神経外科学会, Jan. 2013.
74.	Motohiro Hirasawa, Hideo Mure and Shinji Nagahiro : 難治性疼痛に対する spinal cord stimulation(SCS)療法, 第38回徳島脳神経外科談話会, Dec. 2012.
75.	Hideo Mure, 北里慶子, Yoshifumi Mizobuchi, Teruyoshi Kageji, Shinji Nagahiro, Kazuhito Matsuzaki and Kazuyuki Kuwayama : 悪性神経膠腫におけるAkt2およびAkt3の機能解析, 第30回日本脳腫瘍学会学術集会, Nov. 2012.
76.	Yoshiteru Tada, Hideo Mure, 山本伸昭, Yasuhisa Kanematsu, Motohiro Hirasawa, Junichiro Satomi, Shinji Nagahiro and Koichi Satoh : 発症様式の異なる脊髄硬膜外動静脈瘻の2症例, 第28回NPO法人日本脳神経血管内治療学会学術総会, Nov. 2012.
77.	Hideo Mure : パーキンソン病患者における振戦関連代謝ネットワークパターンの同定と検証, 第24回日本脳循環代謝学会総会, Nov. 2012.
78.	Hideo Mure and Shinji Nagahiro : パーキンソン病患者における振戦関連代謝ネットワークパターンの同定と検証, 第24回日本脳循環代謝学会総会, Nov. 2012.
79.	Hideo Mure, Shinji Nagahiro and Eidelberg David : PETを用いたパーキンソン病におけるDBS-induced neuromodulationの可視化, 第71回日本脳神経外科学会学術総会, Oct. 2012.
80.	Hideo Mure : PETを用いたパーキンソン病におけるDBS-induced neuromodulationの可視化, 社団法人日本脳神経外科学会第71回学術総会, Oct. 2012.
81.	Motohiro Hirasawa, Hideo Mure, Shinji Nagahiro and 村上雅司 : 痙縮に対するバクロフェン髄注(ITB)療法の経験, 第7回NeuroSpinalセミナー, Sep. 2012.
82.	Motohiro Hirasawa, Hideo Mure, Shinji Nagahiro, 西田憲記 and 井上崇文 : 頭蓋頚椎移行部病変に対するinstrumentを用いた固定術, 第27回日本脊髄外科学会, Jun. 2012.
83.	Hideo Mure, Motohiro Hirasawa, Junichiro Satomi, Koichi Satoh and Shinji Nagahiro : 治療に難渋した脊髄硬膜外動静脈瘻の一例, 第27回日本脊髄外科学会, Jun. 2012.
84.	Motohiro Hirasawa, Junichiro Satomi, Hideo Mure, Shinji Nagahiro and Koichi Satoh : 治療に難渋したspinal epidural AVFの1例, 第65回近畿脊髄外科研究会, Mar. 2012.
85.	Motohiro Hirasawa, Junichiro Satomi, Hideo Mure, Shinji Nagahiro and Koichi Satoh : 治療に難渋したspinal epidural AVFの1例, 第13回日本正常圧水頭症学会, Feb. 2012.
86.	Hideo Mure, Motohiro Hirasawa and Shinji Nagahiro : 治療に難渋した脊髄硬膜外動静脈瘻の1例, 第6回ニューロスパイナルセミナー, Jan. 2012.
87.	Hideo Mure, Shinji Nagahiro, 平野成樹, タンクリス and アイデルバーグデビッド : パーキンソン病患者における振戦関連代謝ネットワークパターンの同定と検証, 第51回日本定位・機能神経外科学会, Jan. 2012.
88.	Masaaki Korai, Junichiro Satomi, 山本伸昭, Hideo Mure, Yasuhisa Kanematsu and Shinji Nagahiro : VRDの先端がPcomに迷入した1例, 第43回近畿脳神経血管内手術法ワークショップ, Jan. 2012.
89.	Kazuhito Matsuzaki, Kazuyuki Kuwayama, Yoshifumi Mizobuchi, Hideo Mure, 北里慶子, Teruyoshi Kageji and Shinji Nagahiro : PMLは神経膠芽腫細胞においてNFkBの転写活性を抑制しアポトーシスを誘導する, 第26回日本脳腫瘍学会, Nov. 2008.
90.	Yoshifumi Mizobuchi, Kazuhito Matsuzaki, Kazuyuki Kuwayama, 北里慶子, Hideo Mure, Teruyoshi Kageji and Shinji Nagahiro : グリオーマ細胞におけるREIC/Dkk-3タンパク質の作用, 第8回日本分子脳神経外科学会, Aug. 2007.
91.	Kazuhito Matsuzaki, 友金祐介, Kenji Shimada, Hideo Mure, Tetsuya Tamura, Hidehisa Horiguchi, Teruyoshi Kageji and Shinji Nagahiro : 定位脳組織生検の診断率と合併症, 第16回脳神経外科手術と機器学会, Apr. 2007.

Et cetera, Workshop:

1.	Taku Matsuda, Hiroshi Kagusa, 梅村公子, Nori Sato, Ryoma Morigaki, Hideo Mure, Yasuhisa Kanematsu, Yuki Matsumoto, Masafumi Harada, Shinsuke Katoh and Yasushi Takagi : ロボットスーツHALを用いた脳卒中急性期リハビリテーションの当院での取り組み, 第8回日本脳神経HAL研究会, Feb. 2020.
2.	Hideo Mure : パーキンソン病の外科治療, パーキンソン病の最近の進歩, Nov. 2018.
3.	Hideo Mure : 手足のふるえや痛み，筋緊張，歩行障害をもたらす脳の病気パーキンソン病，振戦，ジストニア，痙縮の最新治療, 脳神経治療最前線セミナー, Nov. 2018.
4.	Hideo Mure : 頚部ジストニアに頚部Burse-SCSを施術した一例, 第3回S8の会, Apr. 2018.
5.	Hideo Mure : 機能性ジストニアについて, 第8回パーキンソン病を勉強しよう IN 四国, Mar. 2018.
6.	Hideo Mure : 日常診療に役立つ機能的脳神経外科治療の症例, 第3回中四国機能神経外科懇話会, Mar. 2018.
7.	Masaaki Korai, Hideo Mure, Yuichi Satoh, Yasuhisa Kanematsu, Junichiro Satomi and Yasushi Takagi : 蝶形頭頂静脈洞近傍にシャントを有し頭蓋内出血で発症した硬膜動静脈瘻の1例, 第43回徳島脳神経外科談話会, Dec. 2017.
8.	Ryoma Morigaki, Hideo Mure, Shinya Ohkita, 小山広士, Ryosuke Miyamoto, Ryuji Kaji and Satoshi Goto : 心因性ジストニアは器質性ジストニアと同じスペクトラムの障害か?, 第2回中四国機能神経外科談話会, Apr. 2017.
9.	Hideo Mure : オフジストニアに対するITB過量投与の経験, 第2回中四国機能神経外科談話会, Apr. 2017.
10.	Shinya Ohkita, Hideo Mure, 小山広士, 中川洋 and Shinji Nagahiro : 歯突起後方儀腫瘍に対して後頭頸椎固定術を行った1例, 第4回徳島脳神経疾患談話会, Mar. 2017.
11.	Hideo Mure : 手の震えや足のむくみ，体が動きにくくなるパーキンソン病, 三好市地域住民のための市民公開講座, Jan. 2016.
12.	Hideo Mure : くび・腰・手足のしびれと痛み -脳神経外科で行うしびれ・痛みの治療-, 三好市地域住民のための市民公開講座, Jan. 2016.
13.	Hideo Mure : くび・腰・手足のしびれと痛み-脳神経外科で行うしびれ・痛みの治療-, 那賀町地域住民のための町民講座, Dec. 2015.
14.	Hideo Mure : 手の震えや足のすくみ，体が動きにくくなるパーキンソン病, 那賀町地域住民のための町民講座, Dec. 2015.
15.	Hideo Mure, 羽星辰哉 and Shinji Nagahiro : 難治性胸髄空洞症の治療経験, 第13回NEURO Spinalセミナー, Jul. 2015.
16.	Hideo Mure : くび・腰・手足のしびれと痛みー脳神経外科で行うしびれ・痛みの治療ー, 吉野川市地域住民のための市民公開講座, Jul. 2015.
17.	Hideo Mure : 手の震えや足のすくみ，体が動きにくくなるパーキンソン病, 吉野川市地域住民のための市民公開講座, Jul. 2015.
18.	Hideo Mure : ジストニアに対するDBS, 第5回パーキンソン病を勉強しよう IN 四国, May 2015.
19.	Hideo Mure : くび・肩・手のしびれと痛み，手の細かいことができなくなる頸椎症, 第1回阿南地域住民のための市民公開講座, Apr. 2015.
20.	Hideo Mure : 手の震えや足のすくみ，体が動きにくくなるパーキンソン病, 第1回阿南地域住民のための市民公開講座, Apr. 2015.
21.	Hideo Mure : 引き抜き損傷後17年後に発症した脊髄くも膜嚢胞の一例, 第12回ニューロスパイナルセミナー, Jan. 2015.
22.	Hideo Mure, Kenji Shimada, Shinji Nagahiro, Kousaku Higashino and Koichi Sairyo : 引き抜き損傷後17年後に発症した脊髄くも膜嚢胞の一例, 第70回近畿脊髄外科研究会, Oct. 2014.
23.	庄野健児, Yasuhito Sato, Kazuhito Matsuzaki, 高瀬憲作, 本藤秀樹 and Hideo Mure : 硬膜外ブラッドパッチが奏功した低髄液圧症候群の1例, 第19回四国脳神経外科カンファレンス, Aug. 2014.
24.	Hideo Mure : パーキンソン病・ジストニアに対する脳深部刺激療法, 第66回徳島神経疾患症例研究会 -西部地区-, Jul. 2014.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Disease- and Deep Brain Stimulation-Related Metabolic Networks using FDG-PET in Movement disorders (Project/Area Number: 16K10788 )
Anti-tumor effects and Regulation of Wnt signaling pathway of adenovirus-mediated DKK3 in glioblastoma (Project/Area Number: 25462264 )
A new therapeutic strategy using adenovirus vector REIC gene in a new glioblastoma (GBM) mice model (Project/Area Number: 23592128 )
Search by Researcher Number (00624355)