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Academic Paper (Judged Full Paper):

1. Suehiro Sakaguchi and Hideyuki Hara :
The first non-prion pathogen identified: neurotropic influenza virus.,
Prion, Vol.16, No.1, 1-6, 2022.
(Tokushima University Institutional Repository: 117592,   DOI: 10.1080/19336896.2021.2015224,   PubMed: 34978525)
2. Dini Agriani Pasiana, Hironori Miyata, Junji Chida, Hideyuki Hara, Morikazu Imamura, Ryuichiro Atarashi and Suehiro Sakaguchi :
Central residues in prion protein PrPC are crucial for its conversion into the pathogenic isoform,
The Journal of Biological Chemistry, Vol.298, No.9, 102381, 2022.
(DOI: 10.1016/j.jbc.2022.102381,   PubMed: 35973512)
3. Hideyuki Hara and Suehiro Sakaguchi :
Virus Infection, Genetic Mutations, and Prion Infection in Prion Protein Conversion.,
International Journal of Molecular Sciences, Vol.22, No.22, 12439, 2021.
(Tokushima University Institutional Repository: 117550,   DOI: 10.3390/ijms222212439,   PubMed: 34830321)
4. Keiji Uchiyama, Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Morikazu Imamura, Tsuyoshi Mori, Hanae Takatsuki, Ryuichiro Atarashi and Suehiro Sakaguchi :
Ethanolamine Is a New Anti-Prion Compound,
International Journal of Molecular Sciences, Vol.22, No.21, 11742, 2021.
(Tokushima University Institutional Repository: 117551,   DOI: 10.3390/ijms222111742,   PubMed: 34769172,   Elsevier: Scopus)
5. Hideyuki Hara, Junji Chida, Keiji Uchiyama, Dini Agriani Pasiana, Etsuhisa Takahashi, Hiroshi Kido and Suehiro Sakaguchi :
Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells.,
Scientific Reports, Vol.11, No.1, 10109, 2021.
(Tokushima University Institutional Repository: 117718,   DOI: 10.1038/s41598-021-89586-6,   PubMed: 33980968)
6. Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Keiji Uchiyama, Yutaka Kikuchi, Tomoko Naito, Yuichi Takahashi, Junji Yamamura, Hisashi Kuromatsu and Suehiro Sakaguchi :
Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire.,
International Journal of Molecular Sciences, Vol.22, No.6, 3268, 2021.
(Tokushima University Institutional Repository: 116339,   DOI: 10.3390/ijms22063268,   PubMed: 33806892,   Elsevier: Scopus)
7. Keiji Uchiyama, Miyata Hironori, Yamaguchi Yoshitaka, Imamura Morikazu, Okazaki Mariya, Pasiana Dini Agriani, Junji Chida, Hideyuki Hara, Atarashi Ryuichiro, Watanabe Hitomi, Kondoh Gen and Suehiro Sakaguchi :
Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106.,
International Journal of Molecular Sciences, Vol.21, No.19, 7260, 2020.
(Tokushima University Institutional Repository: 115634,   DOI: 10.3390/ijms21197260,   PubMed: 33019549,   Elsevier: Scopus)
8. Hideyuki Hara and Suehiro Sakaguchi :
N-terminal Regions of Prion Protein: Functions and Roles in Prion Diseases.,
International Journal of Molecular Sciences, Vol.21, No.17, E6233, 2020.
(Tokushima University Institutional Repository: 115633,   DOI: 10.3390/ijms21176233,   PubMed: 32872280,   Elsevier: Scopus)
9. Junji Chida, Hideyuki Hara, Keiji Uchiyama, Etsuhisa Takahashi, Hironori Miyata, Hidetaka Kosako, Yukiko Tomioka, Toshihiro Ito, Hiroyuki Horiuchi, Haruo Matsuda, Hiroshi Kido and Suehiro Sakaguchi :
Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.,
PLoS Pathogens, Vol.16, No.8, e1008823, 2020.
(Tokushima University Institutional Repository: 115613,   DOI: 10.1371/journal.ppat.1008823,   PubMed: 32845931)
10. Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Junji Chida, Keiji Uchiyama, Kentaro Masujin, Hitomi Watanabe, Gen Kondoh and Suehiro Sakaguchi :
The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region,
Molecular Neurobiology, Vol.57, 1203-1216, 2019.
(DOI: 10.1007/s12035-019-01804-5,   PubMed: 31707632,   Elsevier: Scopus)
11. Ken'ichi Hagiwara, Yuko Sato, Yoshio Yamakawa, Hideyuki Hara, Minoru Tobiume, Yuko Okemoto-Nakamura, Tetsutaro Sata, Motohiro Horiuchi, Hiroaki Shibata and Fumiko Ono :
Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys.,
PLoS ONE, Vol.14, No.5, e0216807, 2019.
(Tokushima University Institutional Repository: 114345,   DOI: 10.1371/journal.pone.0216807,   PubMed: 31095605,   Elsevier: Scopus)
12. Junji Chida, Hideyuki Hara, Masashi Yano, Keiji Uchiyama, Rani Nandita Das, Etsuhisa Takahashi, Hironori Miyata, Yukiko Tomioka, Toshihiro Ito, Hiroshi Kido and Suehiro Sakaguchi :
Prion protein protects mice from lethal infection with influenza A viruses.,
PLoS Pathogens, Vol.14, No.5, e1007049, 2018.
(Tokushima University Institutional Repository: 112206,   DOI: 10.1371/journal.ppat.1007049,   PubMed: 29723291)
13. Hideyuki Hara, Miyata Hironori, Das Rani Nandita, Junji Chida, Yoshimochi Tatenobu, Keiji Uchiyama, Watanabe Hitomi, Kondoh Gen, Yokoyama Takashi and Suehiro Sakaguchi :
Prion Protein Devoid of the Octapeptide Repeat Region Delays BSE Pathogenesis in Mice.,
Journal of Virology, Vol.92, No.1, pii:e01368-17, 2018.
(Tokushima University Institutional Repository: 111465,   DOI: 10.1128/JVI.01368-17,   PubMed: 29046443,   CiNii: 1050845762396495104)
14. Keiji Uchiyama, Mitsuru Tomita, Masashi Yano, Junji Chida, Hideyuki Hara, Nandita Rani Das, Anders Nykjaer and Suehiro Sakaguchi :
Prions amplify through degradation of the VPS10P sorting receptor sortilin.,
PLoS Pathogens, Vol.13, No.6, e1006470, 2017.
(Tokushima University Institutional Repository: 110433,   DOI: 10.1371/journal.ppat.1006470,   PubMed: 28665987)
15. Das Rani Nandita, Miyata Hironori, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Watanabe Hitomi, Kondoh Gen and Suehiro Sakaguchi :
Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice.,
Archives of Virology, Vol.162, No.7, 1867-1876, 2017.
(Tokushima University Institutional Repository: 110119,   DOI: 10.1007/s00705-017-3295-3,   PubMed: 28255815,   Elsevier: Scopus)
16. Taichi Hamanaka, Keiko Nishizawa, Yuji Sakasegawa, Ayumi Oguma, Kenta Teruya, Hiroshi Kurahashi, Hideyuki Hara, Suehiro Sakaguchi and Katsumi Doh-ura :
Melanin or melanin-like substance interacts with the N-terminal portion of prion protein and inhibits abnormal prion protein formation in prion-infected cells.,
Journal of Virology, Vol.91, No.6, e01862-16, 2017.
(DOI: 10.1128/JVI.01862-16,   PubMed: 28077650)
17. Keiji Uchiyama, Miyata Hironori, Masashi Yano, Yoshitaka Yamaguti, Imamura Morikazu, Muramatsu Naomi, Das Rani Nandita, Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Mouse-Hamster Chimeric Prion Protein (PrP) Devoid of N-terminal Residues 23-88 Restores Susceptibility to 22L Prions, But Not to RML Prions in PrP-Knockout Mice.,
PLoS ONE, Vol.9, No.10, e109737, 2014.
(DOI: 10.1371/journal.pone.0109737,   PubMed: 25330286)
18. Ken'ichi Hagiwara, Hideyuki Hara and Kentaro Hanada :
Species-barrier phenomenon in prion transmissibility from a viewpoint of protein science,
The Journal of Biochemistry, Vol.153, No.2, 139-145, 2013.
(DOI: 10.1093/jb/mvs148,   PubMed: 23284000)
19. Hideyuki Hara, Yuko Okemoto-Nakamura, Fumiko Shinkai-Ouchi, Kentaro Hanada, Yoshio Yamakawa and Ken'ichi Hagiwara :
Mouse Prion Protein (PrP) Segment 100 to 104 Regulates Conversion of PrPC to PrPSc in Prion-Infected Neuroblastoma Cells,
Journal of Virology, Vol.86, No.10, 5626-5636, 2012.
(DOI: 10.1128/JVI.06606-11,   PubMed: 22398286)

Review, Commentary:

1. Hideyuki Hara :
ウイルス感染を用いたプリオン病発症モデルの構築,
ブレインサイエンス・レビュー2021, 195-212, Apr. 2021.
2. Hideyuki Hara :
Do not challenge the final proof of the "prion hypothesis "?,
Seibutsu-kogaku Kaishi, Vol.91, No.8, 471, Aug. 2013.
(CiNii: 1540854195288834944,   Elsevier: Scopus)

Proceeding of International Conference:

1. Hagiwara Ken'ichi, Sato Yuko, Yamakawa Yoshio, Hideyuki Hara, Shibata Hiroaki and Ono Fumiko :
Interspecies transmission of atypical L-BSE prion to non-human primates(cynomolgus macaques) alleviates PrPSc glycoform profile of cattle L-BSE trait, but preserves incompetent transmissibility to inbred mice,
PRION 2016, May 2016.
2. Hideyuki Hara, Yuko Okemoto-Nakamura, Fumiko Shinkai-Ouchi, Kentaro Hanada, Yoshio Yamakawa and Ken'ichi Hagiwara :
Mouse prion protein (PrP) segment 100 to 104 regulates conversion of PrPC to PrPSc in prion-infected neuroblastoma cells,
Asian Pacific Prion Symposium 2012, Jul. 2012.

Proceeding of Domestic Conference:

1. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
ネクロトーシスをトリガーとした異常型プリオン蛋白質産生の分子機構,
第45回日本分子生物学会年会, Nov. 2022.
2. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
インフルエンザウイルス感染は神経細胞において感染性プリオンの産生を引き起こす,
第44回日本分子生物学会年会, Dec. 2021.
3. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
プリオン蛋白質はインフルエンザ A ウイルス感染による重症化を軽減する,
第42回日本分子生物学会年会, Dec. 2019.
4. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
ウイルス感染を用いたプリオン病発症機構の解明,
第42回日本分子生物学会年会, Dec. 2019.
5. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
Influenza virus infection triggers de novo generation of prions in neuronal cells,
第41回日本分子生物学会年会, Nov. 2018.
6. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Prion protein provides a protection against influenza A virus infection,
第66回日本ウイルス学会学術集会, Oct. 2018.
7. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Prion protein protects mice from lethal infection with Influenza A virues,
2017年度生命科学系学会合同年次大会 (ConBio2017) 第 40回日本分子生物学会年会/第90回日本 生化学会大会, Dec. 2017.
8. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
Prion-infected neuroblastoma cells are resistant to influenza virus.,
2017年度生命科学系学会合同年次大会 (ConBio2017) 第 40回日本分子生物学会年会/第90回日本 生化学会大会, Dec. 2017.
9. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
蛋白質凝集体「プリオン」による抗インフルエンザウイルス活性機構の解明,
第39回日本分子生物学会年会, Dec. 2016.
10. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
蛋白質凝集体「プリオン」による抗インフルエンザ活性の発見,
第38回日本分子生物学会年会 第88回日本生化学会大会合同大会, Dec. 2015.
11. 清水 七海, 古賀 雄一, 作道 章一, Hideyuki Hara, Suehiro Sakaguchi and 金谷 茂則 :
超好熱菌由来プロテアーゼによるプリオンタンパク質分解の評価,
第87回日本生化学会, Oct. 2014.
12. 古賀 雄一, 清水 七海, 作道 章一, Hideyuki Hara, Suehiro Sakaguchi and 金谷 茂則 :
超好熱菌由来プロテアーゼによるプリオンタンパク質分解の評価,
第66回日本生物工学会大会, Sep. 2014.

Et cetera, Workshop:

1. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
肺で発現する正常プリオン蛋白質の機能解析,
第32回中国四国ウイルス研究会, Jun. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • ネクロトーシスに着目したプリオン病の病態解明と治療法創出 (Project/Area Number: 24K10661 )
  • Studies of prion pathogenesis and non-prion pathogens for preventative and therapeutic development against prion diseases (Project/Area Number: 23K27489 )
  • ネクロトーシスをトリガーとした異常型プリオン蛋白質産生メカニズムの解明 (Project/Area Number: 21K07462 )
  • Elucidation of the pathogenic mechanism and screening of therapeutic compounds in prion disease (Project/Area Number: 19H03548 )
  • Construction of prion disease model using neuroblastoma cells and elucidation of the production mechanism of abnormal prion protein (Project/Area Number: 18K07499 )
  • Prion protein is a target molecule for a novel anti-influenza therapeutic (Project/Area Number: 17K19661 )
  • Elucidation of the vesicular trafficking mechanism for prion propagation on the basis of our previous findings of the disturbed vesicular trafficking in prion disease (Project/Area Number: 26293212 )
  • Elucidation of the prion pathogenic decision mechanism through a copper ion binding site of a prion protein (Project/Area Number: 25870479 )
  • Identification of a host molecule inportant for prion infection (Project/Area Number: 25670422 )
  • Search by Researcher Number (40469953)