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Tokushima UniversityInstitute of Advanced Medical Sciences重点研究部門
Tokushima UniversityResearch ClustersResearch Clusters (Selected)2003004 アトピー性疾患の新規治療ターゲットの解明
Tokushima UniversityGraduate School of Medical SciencesMedical ScienceMolecular Medicine
Tokushima UniversityResearch ClustersResearch Clusters (Specified)2001005 免疫難病の治療開発研究
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Research Activity

His Web Page

Field of Study

Life sciences [Immunology]

Subject of Study

Book / Paper

Book:

1. Yoshiyuki Minegishi :
高IgE症候群,
Nakayama-Shoten Co., Ltd., 東京, Apr. 2017.
2. Yoshiyuki Minegishi :
原発性免疫不全症,
朝倉書店, Jun. 2013.

Academic Paper (Judged Full Paper):

1. Aki Ichihara, Akihiro Yasue, Silvia Naomi Mitsui Akagi, Daishi Arai, Yoshiyuki Minegishi, Seiichi Oyadomari, Issei Imoto and Eiji Tanaka :
The C-terminal region including the MH6 domain of Msx1 regulates skeletal development.,
Biochemical and Biophysical Research Communications, Vol.526, No.1, 62-69, 2020.
(Tokushima University Institutional Repository: 115012,   DOI: 10.1016/j.bbrc.2020.03.068,   PubMed: 32192766,   Elsevier: Scopus)
2. Silvia Naomi Mitsui Akagi, Akihiro Yasue, Kiyoshi Masuda, Takuya Naruto, Yoshiyuki Minegishi, Seiichi Oyadomari, Sumihare Noji, Issei Imoto and Eiji Tanaka :
Novel human mutation and CRISPR/Cas genome-edited mice reveal the importance of C-terminal domain of MSX1 in tooth and palate development.,
Scientific Reports, Vol.6, 2016.
(Tokushima University Institutional Repository: 110156,   DOI: 10.1038/srep38398,   PubMed: 27917906,   Elsevier: Scopus)
3. AY Kreins, MJ Ciancanelli, XF Kong, Yoshiyuki Minegishi and S Boisson-Dupuis :
Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome,
The Journal of Experimental Medicine, 2015.
(DOI: 10.1084/jem.20140280,   PubMed: 26304966,   Elsevier: Scopus)
4. CS Ma, N Wong, Yoshiyuki Minegishi, G Uzel and SG Tangye :
Monogeneic mutatons differentially affect the quality of T follicular helper cells in pateints with human primary immunodeficiencies.,
The Journal of Allergy and Clinical Immunology, 993-1006.e1, 2015.
(DOI: 10.1016/j.jaci.2015.05.036,   PubMed: 26162572,   Elsevier: Scopus)
5. Kazushige Obata-Ninomiya, Kenji Ishiwata, Hidemitsu Tsutsui, Yuichiro Nei, Soichiro Yoshikawa, Yohei Kawano, Yoshiyuki Minegishi, Nobuo Ohta, Naohiro Watanabe, Hirotaka Kanuka and Hajime Karasuyama :
The skin is an important bulwark of acquired immunity against intestinal helminths.,
The Journal of Experimental Medicine, Vol.210, No.12, 2583-2595, 2013.
(DOI: 10.1084/jem.20130761,   PubMed: 24166714)
6. Mayumi Egawa, Kaori Mukai, Soichiro Yoshikawa, Misako Iki, Naofumi Mukaida, Yohei Kawano, Yoshiyuki Minegishi and Hajime Karasuyama :
Inflammatory monocytes recruited to allergic skin acquire an anti-inflammatory M2 phenotype via basophil-derived interleukin-4.,
Immunity, Vol.38, No.3, 570-580, 2013.
(DOI: 10.1016/j.immuni.2012.11.014,   PubMed: 23434060)
7. Yoshiyuki Minegishi and Masako Saito :
Cutaneous Manifestations of Hyper IgE Syndrome.,
Allergology International, Vol.61, No.2, 191-196, 2012.
(DOI: 10.2332/allergolint.12-RAI-0423,   PubMed: 22441639)
8. Cindy S. Ma, Danielle T. Avery, Anna Chan, Marcel Batten, Jacinta Bustamante, Stephanie Boisson-Dupuis, Peter D. Arkwright, Alexandra Y. Kreins, Diana Averbuch, Dan Engelhard, Klaus Magdorf, Sara S. Kilic, Yoshiyuki Minegishi, Shigeaki Nonoyama, Martyn A. French, Sharon Choo, Joanne M. Smart, Jane Peake, Melanie Wong, Paul Gray, Matthew C. Cook, David A. Fulcher, Jean-Laurent Casanova, Elissa K. Deenick and Stuart G. Tangye :
Functional STAT3 deficiency compromises the generation of human T follicular helper cells,
Blood, Vol.119, No.17, 3997-4008, 2012.
(DOI: 10.1182/blood-2011-11-392985,   PubMed: 22403255,   Elsevier: Scopus)
9. H Ogawa, K Mukai, Y Kawano, Yoshiyuki Minegishi and H Karasuyama :
Th2-inducing cytokines IL-4 and IL-33 synergistically elicit the expression of transmembrane TNF- on macrophages through the autocrine action of IL-6.,
Biochemical and Biophysical Research Communications, Vol.420, No.1, 114-118, 2012.
(DOI: 10.1016/j.bbrc.2012.02.124,   PubMed: 22405769)
10. Yoshiyuki Minegishi and Masako Saito :
Molecular mechanisms of the immunological abnormalities in hyper-IgE syndrome.,
Annals of the New York Academy of Sciences, Vol.1246, 34-40, 2011.
(DOI: 10.1111/j.1749-6632.2011.06280.x,   PubMed: 22236428)
11. Masako Saito, Masayuki Nagasawa, Hidetoshi Takada, Toshiro Hara, Shigeru Tsuchiya, Kazunaga Agematsu, Masafumi Yamada, Nobuaki Kawamura, Tadashi Ariga, Ikuya Tsuge, Shigeaki Nonoyama, Hajime Karasuyama and Yoshiyuki Minegishi :
Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.,
The Journal of Experimental Medicine, Vol.208, No.2, 235-249, 2011.
(DOI: 10.1084/jem.20100799,   PubMed: 21300911)

Review, Commentary:

1. Yoshiyuki Minegishi :
原発性免疫不全症のモデル動物,
Inflammation & Immunology, Vol.25, No.3, 62-65, 2017.
2. Yoshiyuki Minegishi :
【小児の症候群】 感染・免疫・アレルギー 高IgE症候群(Job症候群),
The Journal of Pediatric Practice, Vol.79, 352, Apr. 2016.
3. Yoshiyuki Minegishi :
【免疫症候群(第2版)-その他の免疫疾患を含めて-】 原発性免疫不全症候群 免疫不全を伴う特徴的な症候群 高IgE症候群(HIES) AD-HIES(Job's症候群),
Nihon Rinsho. Japanese Journal of Clinical Medicine, 235-237, Mar. 2016.
4. Yoshiyuki Minegishi :
【免疫症候群(第2版)-その他の免疫疾患を含めて-】 原発性免疫不全症候群 免疫不全を伴う特徴的な症候群 高IgE症候群(HIES) Comel-Netherton症候群,
Nihon Rinsho. Japanese Journal of Clinical Medicine, 238-239, Mar. 2016.
5. Yoshiyuki Minegishi :
【免疫症候群(第2版)-その他の免疫疾患を含めて-】 原発性免疫不全症候群 免疫不全を伴う特徴的な症候群 高IgE症候群(HIES) PGM3欠損症,
Nihon Rinsho. Japanese Journal of Clinical Medicine, 240-241, Mar. 2016.
6. Yoshiyuki Minegishi :
高IgE症候群,
臨床免疫アレルギー科, Vol.63, No.3, 251-253, 2015.
(CiNii: 40020393320)
7. Yoshiyuki Minegishi :
原発性免疫不全症の原因遺伝子探索の新展開,
Journal of Clinical and Experimental Medicine, Vol.252, 5-9, 2015.
(CiNii: 40020314940)
8. Yoshiyuki Minegishi :
高IgE症候群の病態形成メカニズム,
Inflammation & Immunology, Vol.22, No.1, 18-22, 2014.
9. Yoshiyuki Minegishi :
Jak-Statシグナルとアレルギー制御,
Experimental Medicine, Vol.31, No.17, 113-117, Oct. 2013.
10. Yoshiyuki Minegishi :
高IgE症候群,
Japanese Journal of Pediatric Medicine, Vol.45, No.6, 1146-1147, Jun. 2013.
11. Yoshiyuki Minegishi :
高IgE症候群の最近の話題,
Medical Science Digest, Vol.39, No.3, 7-8, Mar. 2013.
12. Yoshiyuki Minegishi :
抗体産生不全症―B細胞不全症,
小児科診療, Vol.76, No.3, 419-423, Feb. 2013.
13. Yoshiyuki Minegishi :
A molecular mechanism underlying atopic dermatitis in STAT3 dominant negative hyper-IgE syndrome,
臨床・免疫アレルギー科, Vol.59, No.2, 160-164, Feb. 2013.
(CiNii: 40019594094)
14. Yoshiyuki Minegishi :
Atopic dermatitis caused by hyper-IgE syndrome,
Clinical Immunology & Allergology, Vol.58, No.6, 667-670, Dec. 2012.
(CiNii: 40019542020)
15. Yoshiyuki Minegishi :
高IgE症候群の原因遺伝子解析の現況と臨床応用の可能性,
Japan Medical Journal, Vol.4610, 57-58, 2012.
16. Yoshiyuki Minegishi :
高IgM症候群,
Internal Medicine, Vol.109, No.6, 1497-1498, 2012.
17. Yoshiyuki Minegishi :
高IgE症候群,
Internal Medicine, Vol.109, No.6, 1495-1496, 2012.

Proceeding of International Conference:

1. Takeshi Wada, Yumiko Nishikawa and Yoshiyuki Minegishi :
Analysis of a molecular mechanism underlying the susceptibility to Staphylococcus aureus infection in Hyper-IgE syndrome,
International Congress of Immunology 2016, Aug. 2016.
2. S Minegishi, K Urabe, F Inoue and Yoshiyuki Minegishi :
Specific DSB induction to STAT3 mutations by CRISPR/Cas9,
Keystone symposium Precision Genome Engineering and Synthetic Biology, Jan. 2015.
3. Masako Saito, Karasuyama Hajime and Yoshiyuki Minegishi :
A molecular mechanism underlying atopic dermatitis in hyper-IgE syndrome,
American Academy of Allergy Asthma Immunology, Mar. 2014.
4. Yoshiyuki Minegishi :
A Molecular Mechanism of Hyper IgE Syndrome,
The 4th Japanese Society of Hematology, May 2013.
5. Yoshiyuki Minegishi :
A Molecular Mechanism of Hyper IgE Syndrome,
The 2nd Bizan Symposium of Immunology in the Tokushima University, Jan. 2013.
6. Yoshiyuki Minegishi :
Hyper-IgE syndrome, --- 15th biennial meeting of European Society for Immunodeficiency ---,
Florence, Oct. 2012.
7. Yoshiyuki Minegishi :
Molecular Mechanisms of Hyper IgE Syndrome, --- Brain Korea 21 Project for Functional Foods and Nutrigenomics at Yonsei university ---,
Seoul, Apr. 2012.
8. Yoshiyuki Minegishi :
Molecular Mechanisms of Hyper IgE Syndrome,
Seoul, Apr. 2012.
9. Yoshiyuki Minegishi :
Molecular Mechanisms of Hyper IgE Syndrome, --- New Horizons in the Immune System ---,
Tokushima, Feb. 2012.
10. Yoshiyuki Minegishi :
Molecular Pathogenesis of Hyper IgE Syndrome,
Kyoto, Jan. 2012.
11. Masako Saito, Hajime Karasuyama and Yoshiyuki Minegishi :
A molecular mechanism underlying atopic dermatitis in hyper IgE syndrome,
15th Biennial meeting of the European Society for Immunodeficiencies, Firenze, 2012.

Proceeding of Domestic Conference:

1. Takeshi Wada, Yumiko Nishikawa and Yoshiyuki Minegishi :
Exacerbation of oxazolone-induced atopic dermatitis in a mouse model of hyper-IgE syndrome,
Proceedings of the Japanese Society for Immunology, Vol.46,, Dec. 2017.
2. Takeshi Wada, Yumiko Nishikawa and Yoshiyuki Minegishi :
Basophils promote oxazolone-induced atopic dermatitis in mouse model of hyper-IgE syndrome,
The 45th Annual Meeting of The Japanese Society for Immunology, Dec. 2016.
3. Yumiko Nishikawa, Takeshi Wada and Yoshiyuki Minegishi :
Dysregulated IgE response in a mouse model of hyper-IgE syndrome attributed to B cell-intrincdic abnormality caused by Stat3 mutation,
Proceedings of the Japanese Society for Immunology, Vol.45, Dec. 2016.
4. Yumiko Nishikawa, Takeshi Wada and Yoshiyuki Minegishi :
Dysregulation of T cell-dependent antibody response in a murine model of hyper IgE syndrome,
Proceedings of the Japanese Society for Immunology, Vol.44, 184, Nov. 2015.
5. Takeshi Wada, Yumiko Nishikawa and Yoshiyuki Minegishi :
Hyper-IgE syndrome model mice exhibit the susceptibility to Staphylococcus aureus infection,
The 44th Annual Meeting of the Japanese Society for Immunology, Nov. 2015.
6. Takeshi Wada, Masako Saito, Yumiko Nishikawa and Yoshiyuki Minegishi :
Analysis of the mechanisms of the susceptibility to staphylococcal infection in a mouse model of Hyper-IgE syndrome,
The 43rd Annual Meeting of The Japanease Society for Immunology, Dec. 2014.
7. Yoshiyuki Minegishi :
ヒト遺伝性アレルギー疾患高IgE症候群の発症機構の解明とその制御,
第3回CREST免疫機構領域シンポジウム, Oct. 2014.
8. Yoshiyuki Minegishi :
高IgE症候群の病因と病態の解明,
第21回日本免疫毒性学会学術年会, Sep. 2014.
9. Yoshiyuki Minegishi :
高IgE症候群の病因と病態の解明,
第10回京都臨床アレルギー研究会, Feb. 2014.
10. Yoshiyuki Minegishi :
アトピー性皮膚炎を合併する免疫難病の病態解明,
第43回日本皮膚アレルギー・接触皮膚炎学会, Dec. 2013.
11. Yoshiyuki Minegishi :
アレルギーを合併する免疫不全症 高IgE症候群の病因と病態,
第116回日本小児科学会学術集会, Apr. 2013.
12. Yoshiyuki Minegishi :
高IgE症候群の診断と治療に関する最近の進歩,
第3回東北小児感染症免疫研究会, Feb. 2013.
13. Yoshiyuki Minegishi :
ゲノムとアレルギーの不思議な関係,
Oct. 2012.
14. Yoshiyuki Minegishi :
IgEと免疫異常,
Sep. 2012.
15. Yoshiyuki Minegishi :
高IgE症候群の病因・病態解明へ向けての最近の進歩,
Jul. 2012.
16. Yoshiyuki Minegishi :
高IgE症候群の病因と病態の解明,
第11回小児免疫・アレルギー研究会, Feb. 2012.

Et cetera, Workshop:

1. Takeshi Wada, Masako Saito, Yumiko Nishikawa and Yoshiyuki Minegishi :
高IgE症候群モデルマウスのマスト細胞の機能解析,
感染・免疫クラスターリトリート, Oct. 2014.
2. Takeshi Wada, Masako Saito, Yumiko Nishikawa and Yoshiyuki Minegishi :
高IgE症候群モデルマウスでの黄色ブドウ球菌に対する易感染性の病態,
第13回四国免疫フォーラム, Jun. 2014.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Elucidation of pathophysiology of novel hyper-IgE syndrome (Project/Area Number: 16K15529 )
  • Exome analysis identifed a molecular origin of primary immunodeficiency (Project/Area Number: 16H05356 )
  • Development of a therapeutic genome editing for hyper-IgE syndrome (Project/Area Number: 15K15392 )
  • Comprehensive Analysis of the Regulation of Basophil Development (Project/Area Number: 26670502 )
  • Comprehensive analysis of a molecular mechanism of hyper IgE-emia (Project/Area Number: 25670478 )
  • A molecular mechanism of atopic manifestations of hyper-IgE syndrome (Project/Area Number: 25293232 )
  • Elucidation of a molecular mechanism of osteoporosis caused by a mutation in the STAT3 gene (Project/Area Number: 22390205 )
  • Elucidation of Molecular Mechanisms of Hyper-IgE Syndrome (Project/Area Number: 22021015 )
  • 高IgE症候群モデルマウスの作製とその検討 (Project/Area Number: 21659253 )
  • アトピー性皮膚炎を発症する免疫難病の病態解析 (Project/Area Number: 20060009 )
  • Establishment of genetic diagnosis system and identification of molecular origin for primary immunodeficiencies (Project/Area Number: 19390282 )
  • 先天性免疫不全症の原因遺伝子チロシンキナーゼ2の検討 (Project/Area Number: 18659299 )
  • Analysis of Immunodeficiencies with defective DNA damage response (Project/Area Number: 18591184 )
  • B細胞分化における免疫グロブリンの品質管理とその破綻 (Project/Area Number: 17047013 )
  • Study on a novel mechanism by which IgE/FcεRI mediates chronic allergic inflammation (Project/Area Number: 16616004 )
  • B細胞分化における免疫グロブリンの品質管理とその破綻 (Project/Area Number: 16043218 )
  • Research on Ku70/80 that regulates immune functions and tumorigenesis (Project/Area Number: 15591092 )
  • MOLECULAR FUNCTION OF DNA REPAIR FOR THE DEVELOPMENT (Project/Area Number: 15390323 )
  • ヒストンデアセチラーゼ結合蛋白HDARTの発見と転写制御における役割の解明 (Project/Area Number: 14657242 )
  • Analysis of the new molecules associated with Wiskott-Aldrich syndrome protein. (Project/Area Number: 14370243 )
  • Search by Researcher Number (10343154)