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Research

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Field of Study

Life sciences [Cell biology]
Life sciences [Developmental biology]
Life sciences [Biophysics]

Subject of Study

Book / Paper

Book:

1. Kazuki Horikawa :
蛍光タンパク質ⅳ.cAMPプローブ, 生きてるものは全部観る! イメージングの選び方・使い方100+実験医学増刊 36 No.20 pp.158-159,,
YODOSHA CO., LTD., Apr. 2018.
2. Kazuki Horikawa :
How Low Can You Go? The Numbers of Cells That Make Up Bodies: Large Numbers and Small Numbers, Minorities and Small Numbers from Molecules to Organisms in Biology-Toward a New Understanding of Biological Phenomena, pp.127-133,,
Springer, Apr. 2018.
3. Kazuki Horikawa, Yusaku Ohta and Asuka Mukai :
細胞集団シグナル伝達の少数制御,
Dec. 2017.
4. Kazuki Horikawa :
少数性生物学,
Nippon-Hyoron-Sha Co.,Ltd., Tokyo, Mar. 2017.

Academic Paper (Judged Full Paper):

1. Kazuki Horikawa and Takeharu Nagai :
Live Imaging of cAMP Signaling in D. discoideum Based on a Bioluminescent Indicator, Nano-lantern (cAMP).,
Methods in Molecular Biology, Vol.2483, 231-240, 2022.
(DOI: 10.1007/978-1-0716-2245-2_14,   PubMed: 35286679)
2. Keisho Hirota, Tsuyoshi Hirashima, Kazuki Horikawa, Akihiro Yasoda and Michiyuki Matsuda :
C-type Natriuretic Peptide-induced PKA Activation Promotes Endochondral Bone Formation in Hypertrophic Chondrocytes.,
Endocrinology, Vol.163, No.3, 2022.
(Tokushima University Institutional Repository: 117443,   DOI: 10.1210/endocr/bqac005,   PubMed: 35041746)
3. Kana Beppu, Rie Tsutsumi, Satoshi Ansai, Nana Ochiai, Mai Terakawa, Marie Mori, Masashi Kuroda, Kazuki Horikawa, Takumi Tomoi, Joe Sakamoto, Yasuhiro Kamei, Kiyoshi Naruse and Hiroshi Sakaue :
Development of a screening system for agents that modulate taste receptor expression with the CRISPR-Cas9 system in medaka.,
Biochemical and Biophysical Research Communications, Vol.601, 65-72, 2022.
(Tokushima University Institutional Repository: 116998,   DOI: 10.1016/j.bbrc.2022.02.082,   PubMed: 35228123)
4. Atsushi Mitsuhashi, Kensuke Kondoh, Kazuki Horikawa, Kazuya Koyama, Thi Na Nguyen, Tania Afroj, Hiroto Yoneda, Kenji Otsuka, Hirokazu Ogino, Hiroshi Nokihara, Tsutomu Shinohara and Yasuhiko Nishioka :
Programmed death (PD)-1/PD-ligand 1 blockade mediates antiangiogenic effects by tumor-derived CXCL10/11 as a potential predictive biomarker.,
Cancer Science, Vol.112, No.12, 4853-4866, 2021.
(Tokushima University Institutional Repository: 117305,   DOI: 10.1111/cas.15161,   PubMed: 34628702)
5. T Ichimura, T Kakizuka, Kazuki Horikawa, K Seiriki, A Kasai, H Hashimoto, K Fujita, M T Watanabe and T Nagai :
Exploring rare cellular activity in more than one million cells by a transscale scope.,
Scientific Reports, Vol.11, No.1, 2021.
(Tokushima University Institutional Repository: 117716,   DOI: 10.1038/s41598-021-95930-7,   PubMed: 34400683)
6. Akinobu Z. Suzuki, Taichi Sakano, Hirona Sasaki, Rei Watahiki, Masaki Sone, Kazuki Horikawa and Toshiaki Furuta :
Design and synthesis of gene-directed caged cyclic nucleotides exhibiting cell type selectivity,
Chemical Communications, Vol.57, No.46, 5630-5633, 2021.
(Tokushima University Institutional Repository: 116515,   DOI: 10.1039/d1cc01405f,   PubMed: 34018507)
7. Ayuko Sakane, Taka-aki Yano, Takayuki Uchihashi, Kazuki Horikawa, Yusuke Hara, Issei Imoto, Shusaku Kurisu, Hiroshi Yamada, Kohji Takei and Takuya Sasaki :
JRAB/MICAL-L2 undergoes liquid-liquid phase separation to form tubular recycling endosomes.,
Communications Biology, Vol.4, No.1, 551, 2021.
(Tokushima University Institutional Repository: 117215,   DOI: 10.1038/s42003-021-02080-7,   PubMed: 33976349)
8. Basak S. Udoy, Sattari Sulimon, Hossain Motaleb, Kazuki Horikawa and Komatsuzaki Tamiki :
Transfer entropy dependent on distance among agents in quantifying leader-follower relationships,
Biophysics and Physicobiology, Vol.18, 131-144, 2021.
(DOI: 10.2142/biophysico.bppb-v18.015,   PubMed: 34178564)
9. Anamaria D. Sarca, Luca Sardo, Hirofumi Fukuda, Hiroyuki Matsui, Kotaro Shirakawa, Kazuki Horikawa, Akifumi Takaori-Kondo and Taisuke Izumi :
FRET-Based Detection and Quantification of HIV-1 Virion Maturation,
Frontiers in Microbiology, Vol.12, 647452, 2021.
(Tokushima University Institutional Repository: 116524,   DOI: 10.3389/fmicb.2021.647452,   PubMed: 33767685)
10. Basak S. Udoy, Sattari Sulimon, Hossain Motaleb Md., Kazuki Horikawa and Komatsuzaki Tamiki :
An information-theoretic approach to infer the underlying interaction domain among elements from finite length trajectories in a noisy environment,
The Journal of Chemical Physics, Vol.154, No.3, 034901, 2021.
(DOI: 10.1063/5.0034467,   PubMed: 33499629)
11. Udoy S. Basak, Sulimon Sattari, Kazuki Horikawa and Tamiki Komatsuzaki :
Inferring domain of interactions among particles from ensemble of trajectories,
Physical Review E, Vol.102, No.1-1, 012404, 2020.
(DOI: 10.1103/PhysRevE.102.012404,   PubMed: 32795064)
12. Yusaku Ohta, Toshiaki Furuta, Takeharu Nagai and Kazuki Horikawa :
Red fluorescent cAMP indicator with increased affinity and expanded dynamic range.,
Scientific Reports, Vol.8, No.1, 1866, 2018.
(Tokushima University Institutional Repository: 112438,   DOI: 10.1038/s41598-018-20251-1,   PubMed: 29382930)
13. Ayuko Sakane, Shin Yoshizawa, Masaomi Nishimura, Yuko Tsuchiya, Natsuki Matsushita, Kazuhisa Miyake, Kazuki Horikawa, Issei Imoto, Chiharu Mizuguchi, Hiroyuki Saito, Takato Ueno, Sachi Matsushita, Hisashi Haga, Shinji Deguchi, Kenji Mizuguchi, Hideo Yokota and Takuya Sasaki :
Conformational plasticity of JRAB/MICAL-L2 provides "law and order" in collective cell migration.,
Molecular Biology of the Cell, Vol.27, No.20, 3095-3108, 2016.
(Tokushima University Institutional Repository: 114562,   DOI: 10.1091/mbc.E16-05-0332,   PubMed: 27582384)
14. Yusaku Ohta, Takanori Kamagata, Asuka Mukai, Shinji Takada, Takeharu Nagai and Kazuki Horikawa :
Nontrivial Effect of the Color-Exchange of a Donor/Acceptor Pair in the Engineering of Förster Resonance Energy Transfer (FRET)-Based Indicators.,
ACS Chemical Biology, Vol.11, No.7, 1816-1822, 2016.
(DOI: 10.1021/acschembio.6b00221,   PubMed: 27232891,   Elsevier: Scopus)
15. Asuka Mukai, Aya Ichiraku and Kazuki Horikawa :
Reliable handling of highly A/T-rich genomic DNA for efficient generation of knockin strains of Dictyostelium discoideum.,
BMC Biotechnology, Vol.16, 37, 2016.
(Tokushima University Institutional Repository: 114375,   DOI: 10.1186/s12896-016-0267-8,   PubMed: 27075750)
16. James Derek Hanson, Shingen Nakamura, Ryota Amachi, Masahiro Hiasa, Asuka Oda, Daisuke Tsuji, Kohji Itoh, Takeshi Harada, Kazuki Horikawa, Jumpei Teramachi, Hirokazu Miki, Toshio Matsumoto and Masahiro Abe :
Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.,
Oncotarget, Vol.6, No.32, 33568-33586, 2015.
(Tokushima University Institutional Repository: 109501,   DOI: 10.18632/oncotarget.5598,   PubMed: 26384349,   Elsevier: Scopus)
17. Michihiro Nakamura, Koichiro Hayashi, Nakano Mutsuki, Kanadani Takafumi, Miyamoto Kazue, Toshinari Kori and Kazuki Horikawa :
Identification of Polyethylene Glycol-Resistant Macrophages on Stealth Imaging In Vitro Using Fluorescent Organosilica Nanoparticles,
ACS Nano, Vol.9, No.2, 1058-1071, 2015.
(DOI: 10.1021/nn502319r,   PubMed: 25629765,   Elsevier: Scopus)
18. Kazuki Horikawa :
Recent progress in the development of genetically encoded Ca2+ indicators.,
The Journal of Medical Investigation : JMI, Vol.62, No.1-2, 24-28, 2015.
(Tokushima University Institutional Repository: 111241,   DOI: 10.2152/jmi.62.24,   PubMed: 25817279,   Elsevier: Scopus)
19. Takeharu Nagai, Kazuki Horikawa, Kenta Saito and Tomoki Matsuda :
Genetically encoded Ca(2+) indicators; expanded affinity range, color hue and compatibility with optogenetics.,
Frontiers in Molecular Neuroscience, Vol.7, 90, 2014.
(DOI: 10.3389/fnmol.2014.00090,   PubMed: 25505381)
20. Kazunori Kanemaru, Hiroshi Sekiya, Ming Xu, Kaname Satoh, Nami Kitajima, Keitaro Yoshida, Yohei Okubo, Takuya Sasaki, Satoru Moritoh, Hidetoshi Hasuwa, Masaru Mimura, Kazuki Horikawa, Ko Matsui, Takeharu Nagai, Masamitsu Iino and Kenji F. Tanaka :
In vivo visualization of subtle, transient, and local activity of astrocytes using an ultrasensitive Ca(2+) indicator.,
Cell Reports, Vol.8, No.1, 311-318, 2014.
(DOI: 10.1016/j.celrep.2014.05.056,   PubMed: 24981861)
21. Kazuki Horikawa and 永井 健治 :
Ca2+イメージングで解き明かすCa2+動態の時空間統御機構,
Clinical Calcium, Vol.23, No.4, 69-75, 2013.
(DOI: 10.20837/4201304069)
22. Kazuki Horikawa and Takeharu Nagai :
[Spatiotemporal regulation of Ca(2 +) dynamics in live cells revealed by Ca(2 +) imaging].,
Clinical Calcium, Vol.23, No.4, 527-533, 2013.
(PubMed: 23545742)
23. Tomoki Matsuda, Kazuki Horikawa, Kenta Saito and Takeharu Nagai :
Highlighted Ca2+ imaging with a genetically encoded 'caged' indicator.,
Scientific Reports, Vol.3, 1398, 2013.
(DOI: 10.1038/srep01398,   PubMed: 23474844)
24. Kohei Nishimura, Masamichi Ishiai, Kazuki Horikawa, Tatsuo Fukagawa, Minoru Takata, Haruhiko Takisawa and T Masato Kanemaki :
Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.,
Molecular Cell, Vol.47, No.4, 511-522, 2012.
(DOI: 10.1016/j.molcel.2012.05.047,   PubMed: 22771115)
25. Kenta Saito, Y-F Chang, Kazuki Horikawa, Noriyuki Hatsugai, Yuriko Higuchi, Mitsuru Hashida, Yu Yoshida, Tomoki Matsuda, Yoshiyuki Arai and Takeharu Nagai :
Luminescent proteins for high-speed single-cell and whole-body imaging.,
Nature Communications, Vol.3, 1262, 2012.
(DOI: 10.1038/ncomms2248,   PubMed: 23232392)
26. Yoshiyuki Yamada, Takayuki Michikawa, Mitsuhiro Hashimoto, Kazuki Horikawa, Takeharu Nagai, Atsushi Miyawaki, Michael Häusser and Katsuhiko Mikoshiba :
Quantitative comparison of genetically encoded Ca indicators in cortical pyramidal cells and cerebellar Purkinje cells.,
Frontiers in Cellular Neuroscience, Vol.5, 2011.
(DOI: 10.3389/fncel.2011.00018,   PubMed: 21994490)
27. Kazuki Horikawa, Yoshiyuki Yamada, Tomoki Matsuda, Kentarou Kobayashi, Mitsuhiro Hashimoto, Toru Matsu-ura, Atsushi Miyawaki, Takayuki Michikawa, Katsuhiko Mikoshiba and Takeharu Nagai :
Spontaneous network activity visualized by ultrasensitive Ca(2+) indicators, yellow Cameleon-Nano.,
Nature Methods, Vol.7, No.9, 729-732, 2010.
(DOI: 10.1038/nmeth.1488,   PubMed: 20693999)
28. Kenta Saito, Noriyuki Hatsugai, Kazuki Horikawa, Kentaro Kobayashi, Toru Matsu-Ura, Katsuhiko Mikoshiba and Takeharu Nagai :
Auto-luminescent genetically-encoded ratiometric indicator for real-time Ca2+ imaging at the single cell level.,
PLoS ONE, Vol.5, No.4, e9935, 2010.
(DOI: 10.1371/journal.pone.0009935,   PubMed: 20376337)
29. Kazuki Horikawa and Takeharu Nagai :
[Ultra-sensitive and large-scale imaging of cellular coupled oscillator systems].,
Tanpakushitsu Kakusan Koso, Vol.54, No.15, 1945-1951, 2009.
(PubMed: 19999158)
30. Chie Satou, Yukiko Kimura, Tsunehiko Kohashi, Kazuki Horikawa, Hiroyuki Takeda, Yoichi Oda and Shin-ichi Higashijima :
Functional role of a specialized class of spinal commissural inhibitory neurons during fast escapes in zebrafish.,
The Journal of Neuroscience, Vol.29, No.21, 6780-6793, 2009.
(DOI: 10.1523/JNEUROSCI.0801-09.2009,   PubMed: 19474306)
31. Wataru Tomosugi, Tomoki Matsuda, Tomomi Tani, Tomomi Nemoto, Ippei Kotera, Kenta Saito, Kazuki Horikawa and Takeharu Nagai :
An ultramarine fluorescent protein with increased photostability and pH insensitivity.,
Nature Methods, Vol.6, No.5, 351-353, 2009.
(DOI: 10.1038/nmeth.1317,   PubMed: 19349978)
32. Masashi Tanimoto, Yukiko Ota, Kazuki Horikawa and Yoichi Oda :
Auditory input to CNS is acquired coincidentally with development of inner ear after formation of functional afferent pathway in zebrafish.,
The Journal of Neuroscience, Vol.29, No.9, 2762-2767, 2009.
(DOI: 10.1523/JNEUROSCI.5530-08.2009,   PubMed: 19261871)
33. Saori Nagayoshi, Eriko Hayashi, Gembu Abe, Naoki Osato, Kazuhide Asakawa, Akihiro Urasaki, Kazuki Horikawa, Kazuho Ikeo, Hiroyuki Takeda and Koichi Kawakami :
Insertional mutagenesis by the Tol2 transposon-mediated enhancer trap approach generated mutations in two developmental genes: tcf7 and synembryn-like.,
Development, Vol.135, No.1, 159-169, 2008.
(DOI: 10.1242/dev.009050,   PubMed: 18065431)
34. Kana Ishimatsu, Kazuki Horikawa and Hiroyuki Takeda :
Coupling cellular oscillators: a mechanism that maintains synchrony against developmental noise in the segmentation clock.,
Developmental Dynamics, Vol.236, No.6, 1416-1421, 2007.
(DOI: 10.1002/dvdy.21139,   PubMed: 17420984)
35. Hiroyuki Takeda and Kazuki Horikawa :
[Basic principle of the segmentation clock: synchronization and robustness to noise].,
Tanpakushitsu Kakusan Koso, Vol.52, No.3, 236-242, 2007.
(PubMed: 17352188)
36. Kazuki Horikawa, Kana Ishimatsu, Eiichi Yoshimoto, Shigeru Kondo and Hiroyuki Takeda :
Noise-resistant and synchronized oscillation of the segmentation clock.,
Nature, Vol.441, No.7094, 719-723, 2006.
(DOI: 10.1038/nature04861,   PubMed: 16760970)

Academic Paper (Unrefereed Paper):

1. Taishi Kakizuka, Yusuke Hara, Yusaku Ohta, Asuka mukai, Aya Ichiraku, Yoshiyuki Arai, Taro Ichimura, Takeharu Nagai and Kazuki Horikawa :
Cellular logics bringing the symmetry breaking in spiral nucleation revealed by trans-scale imaging,
bioRxiv, 2020.
(DOI: 10.1101/2020.06.29.176891)

Academic Letter:

1. Kazuki Horikawa :
Fluorescent probes for bio-imaging of bone,
THE BONE, Vol.28, No.2, 67-72, 2014.
(CiNii: 1010000782141477770)

Proceeding of International Conference:

1. Kazuki Horikawa :
PacifiChem2021,
Honolulu, USA, Dec. 2021.
2. Masaki Morishima, Kazuki Horikawa and Makoto Funaki :
Mechanically Physiological Microenvironment Sensitizes Primary Cardiomyocytes to Glucotoxicity; New In Vitro Diabetic Heart Research Model,
Diabetes, San Diego, Jun. 2017.
3. Naoki Muguruma, Yoshihiko Miyamoto, Shota Fujimoto, Tadahiko Nakagawa, Shinji Kitamura, Tetsuo Kimura, Koichi Okamoto, Hiroshi Miyamoto, Kazuki Horikawa and Tetsuji Takayama :
Endoscopic molecular imaging of colorectal cancer targeting epidermal growth factor receptor.,
APDW2015, Taipei, Dec. 2015.
4. Takashi Uebanso, Takaaki Shimohata, Iba Hitomi, Nishimura Kazuya, Taniguchi Yuichi, Kazuki Horikawa, Mutsumi Nakahashi, Kazuaki Mawatari and Akira Takahashi :
COMBINATION BETWEEN A FEW T3SS INJECTISOME AND A LOT EFFECTOR FOR KILLING HOST CELLS ON VIBRIO PARAHAEMOLYTICUS,
6th FEMS Microbiology Congress, Jun. 2015.
5. Kazuki Horikawa :
Japan Taiwan Joiunt symposium for Paradigm Innovation in Biology: novel strategy and thinking,
Academia Sinica, Taipei, Taiwan, Jul. 2012.

Proceeding of Domestic Conference:

1. Kazuki Horikawa :
第60回日本生体医工学会・第36回日本生体磁気学会 合同大会,
Jun. 2021.
2. Kazuki Horikawa :
第42回日本分子生物学会,
Dec. 2019.
3. Kazuki Horikawa :
ICSB2019,
Oct. 2019.
4. Kazuki Horikawa :
第57回日本生物物理学会,
Sep. 2019.
5. Kazuki Horikawa :
日本細胞生物学会,
Jun. 2019.
6. Kazuki Horikawa :
シンギュラリティ生物学キックオフシンポジウム,
Sep. 2018.
7. Kazuki Horikawa :
第56回日本生物物理学会年会での講演,
Sep. 2018.
8. Kazuki Horikawa :
第29回細胞生物学ワークショップ・「FRETの基礎」「多点走査顕微鏡」講義および実習,
Aug. 2018.
9. Kazuki Horikawa :
第29回細胞生物学ワークショップ・「蛍光タンパク質の性質」講義,
Aug. 2018.
10. Kazuki Horikawa :
脳構築における発生時間と場の連携・第3回領域班会議への出席と発表,
Jul. 2018.
11. Kazuki Horikawa :
Red fluorescent cAMP indicator with increased affinity and expanded dynamic range,
The 18th Annual Meeting of the Protein Science Society of Japan, Niigata, Japan,, Jun. 2018.
12. Kazuki Horikawa :
1分子から個体レベルまでの多階層バイオイメージング,
公開シンポジウム 次世代バイオイメージングの研究の展望, Aug. 2017.
13. Kazuki Horikawa :
バイオイメージング拠点四国研究会,
Nov. 2016.
14. Kazuki Horikawa :
京都大学生命科学リトリート,
Oct. 2016.
15. Kazuki Horikawa :
in vivo イメージング 研究会,
Jul. 2016.

Et cetera, Workshop:

1. Taishi Kakizuka, Yusuke Hara, Taro Ichimura, Takeharu Nagai and Kazuki Horikawa :
社会性アメーバにおける時空間自己組織化過程の多段階シンギュラリティ AMATERAS ver.1 を用いた定量トランススケール解析,
新学術領域研究「シンギュラリティ生物学」第5回領域会議, May 2021.
2. Yusuke Hara, Kazuki Horikawa and Taishi Kakizuka :
リエントリーからラセンへ:自発形成されるラセン波の起源,
新学術領域研究「シンギュラリティ生物学」第5回領域会議, May 2021.
3. Kazuki Horikawa, Yusuke Hara and Taishi Kakizuka :
AMATERAS観察で明らかになったラセン波の自発形成メカニズム,
新学術領域研究「シンギュラリティ生物学」第5回領域会議, May 2021.
4. Kazuki Horikawa :
シンギュラリティ生物学デザイン思考研究会,
Feb. 2019.
5. Kazuki Horikawa :
第7回さきがけ終了領域研究会,
Oct. 2018.
6. Kazuki Horikawa :
イメージングプラットフォームに関する会議,
Aug. 2018.
7. Kazuki Horikawa :
新学術領域「シンギュラリティ生物学」・第1回領域班会議,
Aug. 2018.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Novel mechanism of chronic inflammation in progression and destabilization of atherosclerotic plaque (Project/Area Number: 19H03654 )
  • Analysis of the singularity cells controlling the pattern formation of multicellular system (Project/Area Number: 18H05415 )
  • Molecular mechanisms translating the pulse information into developmental time (Project/Area Number: 17H05770 )
  • Single molecule analysis in the generation of oscillatory circuit for cAMP signaling (Project/Area Number: 15K14491 )
  • マクロファージの異常な活性化に起因する慢性炎症発症機序の解明 (Project/Area Number: 25113716 )
  • in vivo imaging analysis of cGMP dynamics in the smooth muscle of circulatory system (Project/Area Number: 25840050 )
  • Visualization of chronic inflammation in arterial wall and perivascular adipose tissue (Project/Area Number: 25293184 )
  • 多細胞社会の秩序形成を司る細胞個性のマルチスケール定量と操作 (Project/Area Number: 23127512 )
  • Development of molecular probes and photo manipulation tools - Technologies for visualization and control of small number of biomolecules (Project/Area Number: 23115003 )
  • Spying minority in biological phenomena -Toward bridging dynamics between individual and ensemble processes- (Project/Area Number: 23115001 )
  • Development of multi-scale and functional imaging technique to quantify the fluctuation in intercellular signaling (Project/Area Number: 22770182 )
  • エンハンサートラップ法とライブイメージングを軸とした聴覚システム発生機構の研究 (Project/Area Number: 18870004 )
  • Elucidation of self-organization process in living organism by small number of molecules using functional imaging (Project/Area Number: 18687014 )
  • Search by Researcher Number (70420247)