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Tokushima University > Faculty of Dentistry > Course in Dentistry > Basic Oral Sciences > Preventive Dentistry >
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Research Activity

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Field of Study

Preventive Dentistry

Subject of Study

天然ハーブを用いた口腔内環境改善に関する研究 (ヒト歯肉線維芽細胞, 天然ハーブ, 歯周病, 慢性炎症, 組織修復)

Book / Paper

Academic Paper (Judged Full Paper):

1. Rita Cristina Orihuela Campos, Naofumi Tamaki, Rie Mukai, Makoto Fukui, Kaname Miki, Junji Terao and Hiro-O Ito :
Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts.,
Journal of Clinical Biochemistry and Nutrition, Vol.56, No.3, 220-227, 2015.
(Tokushima University Institutional Repository: 109399,   DOI: 10.3164/jcbn.14-129,   PubMed: 26060353,   Elsevier: Scopus)
2. Masaaki Yokoyama, Makoto Fukui, Kaname Masuda, Natsuko Takamatsu, Jurou Okada, 裕光 武部, Kosuke Kataoka and Hiro-O Ito :
リアルタイム定量PCR(qPCR)法による唾液中の総細菌数の測定 口腔清潔度の指標としての試み,
Journal of Dental Health, Vol.59, No.3, 183-189, 2009.
(CiNii: 110008460531)
3. Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Nozomi Yokoyama, Kaname Masuda, Daisuke Hinode and Ryo Nakamura :
フッ化物洗口実施校におけるう蝕予防効果,
Journal of Dental Health, Vol.55, No.5, 552-558, 2005.
(CiNii: 10016760398)
4. Masaaki Yokoyama, Daisuke Hinode, Kaname Masuda, Masami Yoshioka and Daniel Grenier :
Effect of female sex hormones on Campylobacter rectus and human gingival fibroblasts,
Oral Microbiology and Immunology, Vol.20, No.4, 239-243, 2005.
(DOI: 10.1111/j.1399-302X.2005.00222.x,   PubMed: 15943769)
5. Masami Yoshioka, Nozomi Yokoyama, Kaname Masuda, Honna Tomoaki, Daisuke Hinode, Ryo Nakamura, Rouabhia Mahmoud, Mayrand Denis and Grenier Daniel :
Effect of hydroxamic acid-based MMP inhibitors on human gingival cells and Porphyromonas gingivalis,
Journal of Periodontology, Vol.74, No.8, 1219-1224, 2003.
(DOI: 10.1902/jop.2003.74.8.1219,   PubMed: 14514237)
6. Kaname Masuda, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura :
Purification and characterization of arginine carboxypeptidase produced by Porphyromonas gingivalis,
Infection and Immunity, Vol.70, No.4, 1807-1815, 2002.
(DOI: 10.1128/IAI.70.4.1807-1815.2002,   PubMed: 11895942)
7. Kaname Masuda, Tomita Koji, Hayashi Hiroyuki, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura :
Consumption of Peptide-derived Arginine by a Periodontopathogenic Bacterium, Porphyromonas gingivalis,
Anaerobe, Vol.7, No.4, 209-217, 2001.
(DOI: 10.1006/anae.2001.0383,   Elsevier: Scopus)
8. Masami Yoshioka, Kaname Masuda, Daisuke Hinode, 林 裕行 and Ryo Nakamura :
歯周病原性細菌のプロテアーゼに対するモノクローナル抗体を利用した歯周病診断の試み,
Journal of Dental Health, Vol.49, No.1, 71-78, 1999.
9. Daisuke Hinode, Masami Yoshioka, Shin-ichi Tanabe, Osamu Miki, Kaname Masuda and Ryo Nakamura :
The GroEL-like protein from Campylobacter rectus: immunological characterization and interleukin-6 and -8 induction in human gingival fibroblast,
FEMS Microbiology Letters, Vol.167, No.1, 1-6, 1998.
10. Masami Yoshioka, 大塚 千亜紀, Kanako Tamatani, Kaname Masuda, 三木 修, 林 祐行 and Ryo Nakamura :
Porphyromonas gingivalisの産生するアルギニン代謝関連酵素と細胞凝集活性との関連について,
Journal of Dental Health, Vol.47, 83-88, 1997.
11. Daisuke Hinode, Kaname Masuda, Masami Yoshioka, H Hayashi, R Nakamura, D Grenier and D Mayrand :
Biological and antigenic characterization of three BApNA-hydrolyzing proteases from the culture supernatant of Porphyromonas gingivalis,
Oral Microbiology and Immunology, Vol.11, No.1, 8-14, 1996.
12. Daisuke Hinode, Kaname Masuda, Masami Yoshioka, Kiyoko Watanabe, Toshio Umemoto, Daniel Grenier, Denis Mayrand and Ryo Nakamura :
Immunological characterization and localization of a Porphyromonas gingivalis BApNA-hydrolyzing protease possessing hemagglutinating activity,
FEMS microbiology letters, Vol.131, No.2, 211-217, 1995.
13. Daisuke Hinode, Kaname Masuda, Masami Yoshioka, Hiroyuki Hayashi and Ryo Nakamura :
Purification of an Extracellular Soluble Protease Possessing BApNA Hydrolytic Activity from Culture Supernatants of Porphyromonas gingivalis,
Journal of Dental Health, Vol.44, No.3, 308-314, 1994.

Academic Paper (Unrefereed Paper):

1. Kaname Miki, Naofumi Tamaki and Hiro-O Ito :
Utility of Natural Herbs -Focusing on Dental Field Use,
Journal of Oral Health and Biosciences, Vol.32, No.1, 16-25, 2019.
(Tokushima University Institutional Repository: 113665,   DOI: 10.20738/johb.32.1_16,   CiNii: 130007672857)

Proceeding of International Conference:

1. Makoto Fukui, Kaname Miki, Kitamura Masayasu, Hayashida Hideaki, Kawasaki Koji, Rita Cristina Orihuela Campos, Naofumi Tamaki, Maeda Takahiro, Saito Toshiyuki and Hiro-O Ito :
Porphyromonas gingivalis infection may affect anti-atheroschlerotic antibody to phosphorylcholine.,
The 12th International Conference of Asia Academy of Preventive Dentistry, May 2016.
2. Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito :
Balance is the key: resveratrol revert oxidative stress conditions in gingival fibroblasts,
第93回IADR, Mar. 2015.
3. Makoto Fukui, Kaname Miki, Naofumi Tamaki and Hiro-O Ito :
Relationship between atherosclerosis and anti-phosphorylcholine antibodies in saliva and plasma,
ICAAPD, ウランバートル, Sep. 2012.
4. Masami Yoshioka, Kaname Masuda, Nozomi Yokoyama, Masaaki Yokoyama, Shin-ichi Tanabe, Daisuke Hinode and Daniel Grenier :
Contribution of Peptostreptococcus Micros proteases in cytokine response by human gingival fibroblasts,
4th General Annual Meeting of the International Conference on Protease Inhibitors, Quebec City, Oct. 2005.
5. Nozomi Yokoyama, Kaname Masuda, Masami Yoshioka, Masaaki Yokoyama, Daisuke Hinode and Ryo Nakamura :
Effect of Hydroxamic Acid-Based MMP Inhibitors on Human Gingival Cells,
80th General session of the International Association for Dental Research, San Diego, Mar. 2002.
6. Kaname Masuda, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura :
Characterization of Arginine Carboxypeptidase from Porphryomonas gingivalis,
Journal of Dental Research, Vol.78, Vancouver, Mar. 1999.
7. Daisuke Hinode, Shin-ichi Tanabe, Osamu Miki, Kaname Masuda, Masami Yoshioka and Ryo Nakamura :
Interleukin Secretion by the GroEL-like Protein from Campylobacter rectus.,
Journal of Dental Research, Vol.78, No.Special Issue, 418, Vancouver, Canada, Mar. 1999.
8. Daisuke Hinode, Kaname Masuda, Masami Yoshioka, H Hayashi, R Nakamura, D Grenier and D Mayrand :
Characterization of three BApNA hydrolyzing proteases from Porphyromonas gingivalis,
24th Annual meeting of the American Association for Dental Research, San Antonio, U.S.A, Mar. 1995.

Proceeding of Domestic Conference:

1. Shibyoh Oh, Akari Watanabe, Miwa Matsuyama, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito :
ATP測定法による口腔内細菌数の評価,
第30回近畿・中国・四国口腔衛生学会総会, Sep. 2019.
2. 大毛 健一郎, 野上 幸裕, Naofumi Tamaki, Kaname Miki and Hiro-O Ito :
口腔内清掃による口臭値と口腔内細菌数指標の変化,
第55回 四国歯学会, Sep. 2019.
3. Chen Shu, Naofumi Tamaki, Kaname Miki and Hiro-O Ito :
Preventive effects of resveratrol against 5-fluorouracil induced cytotoxicity in HaCaT cells,
第68回日本口腔衛生学会・総会, May 2019.
4. Kaname Miki, Makoto Fukui, CHEN SHU, Naofumi Tamaki and Hiro-O Ito :
天然ハーブ・キャッツクロー抽出物の歯周病原菌に対する抗菌効果,
第29回近畿中国四国口腔衛生学会, Sep. 2018.
5. Kaname Miki :
天然ハーブの有用性ー歯科の領域を中心にー,
第53回例会四国歯学会, Jul. 2018.
6. Makoto Fukui, CHEN SHU, Kaname Miki, Naofumi Tamaki, 福田 功 and Hiro-O Ito :
歯肉炎症の評価における3種の唾液潜血検査の有用性の検討 第28回近畿・中国・四国口腔衛生学会総会 2017年10月1日 広島大学歯学部(広島市),
第28回近畿・中国・四国口腔衛生学会総会, Oct. 2017.
7. Makoto Fukui, CHEN SHU, Kaname Miki, Naofumi Tamaki, 福田 功 and Naofumi Tamaki :
歯肉炎症の評価における3種の唾液潜血検査の有用性の検討,
第28回近畿・中国・四国口腔衛生学会・総会, Oct. 2017.
8. Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito :
唾液潜血検査の判定を妨害する因子の検索,
第27回近畿・中国・四国口腔衛生学会・総会, Oct. 2016.
9. Makoto Fukui, Kaname Miki, K Kitamura, H Hayashida, K Kawasaki, Rita Cristina Orihuela Campos, Naofumi Tamaki, T Maeda, T Saito and Hiro-O Ito :
Atherosclerosis-preventive activity of anti-phosphorylcholine antibody may be interfered by infection with Porphyromonas gingivalis : The Nagasaki Islands study,
63rd Annual Meeting of the Japanese Association of Dental Research, Oct. 2015.
10. 水野 昭彦, 松尾 亮, 鈴木 雅博, Naofumi Tamaki, Makoto Fukui, Kaname Miki, 松瀬 亮一 and Hiro-O Ito :
市民検診と糖尿病患者データにおける歯肉溝浸出液バイオマーカーの比較検討,
第64回 口腔衛生学会総会, May 2015.
11. Naofumi Tamaki, Rita Cristina Orihuela Campos, Makoto Fukui, Kaname Miki and Hiro-O Ito :
水素水の抗酸化・抗炎症作用の検討,
第64回 口腔衛生学会総会, May 2015.
12. Makoto Fukui, 岡田 寿郎, Kaname Miki, Naofumi Tamaki and Hiro-O Ito :
``標準的な成人歯科健診プログラム・保健指導マニュアル''に基づいた歯科保健事業の効果について,
第64回 口腔衛生学会総会, May 2015.
13. 松尾 亮, 水野 昭彦, 鈴木 雅博, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito :
歯肉溝浸出液バイオマーカーと血液データの比較検討,
第49回日本成人病(生活習慣病)学会, Jan. 2015.
14. Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito :
Levels of various cytokines in human saliva from generally healthy individuals.,
62nd Annual Meeting of the Japanese Association for Dental Research, Dec. 2014.
15. Kenjiroh Takao, Mamiko Nii, Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito :
歯肉炎症の客観的・定量的診断を目指した市販免疫クロマトグラフィー唾液潜血テストの改良,
第25回 近畿・中国・四国 口腔衛生学会総会, Oct. 2014.
16. 水野 昭彦, 松尾 亮, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito :
歯肉溝浸出液バイオマーカーと血液データの比較,
第25回 近畿・中国・四国 口腔衛生学会総会, Oct. 2014.
17. Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito :
Effects of three different antioxidants on human gingival fibroblasts exposed to oxidative stress,
2014 Tokushima Bioscience retreat, Sep. 2014.
18. Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito :
健常者における唾液中サイトカインプロファイルの解析,
第63回 口腔衛生学会総会, May 2014.
19. Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito :
Effects of three antioxidant compounds on human gingival fibroblasts under oxidative stress,
第63回 口腔衛生学会総会, May 2014.
20. Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito :
Effects of different antioxidants on human gingival fibroblasts under oxidative stress,
第5回心・血管クラスターミニリトリート, Jan. 2014.
21. Makoto Fukui, Kaname Miki, Naofumi Tamaki and Hiro-O Ito :
唾液中サイトカインと口腔健康状態の関連性,
第24回近畿・中国・四国口腔衛生学会総会, Oct. 2013.
22. Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito :
Effects of different antioxidants on the biological properties of human gingival fibroblasts response toward ROS,
Tokushima Bioscience retreat, Sep. 2013.
23. Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito :
Real time xCELLigence analysis of antioxidant agents on human gingival fibroblast cells viability,
第62回日本口腔衛生学会総会, May 2013.
24. Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito :
健常者における唾液中サイトカイン分析,
第62回日本口腔衛生学会・総会, May 2013.
25. Makoto Fukui, Naofumi Tamaki, Kaname Miki and Hiro-O Ito :
動脈硬化リスク評価のための唾液・血液中の抗ホスホリルコリン抗体の測定,
心血管クラスターリトリート, Jan. 2013.
26. Makoto Fukui, Kaname Miki, Naofumi Tamaki and Hiro-O Ito :
動脈硬化リスク評価のための唾液・血液中の抗ホスホリルコリン抗体の測定,
第5回日本口腔検査学会総会・学術大会, Aug. 2012.
27. SA Mulyatno, Kosuke Kataoka, Makoto Fukui, Kaname Miki, RC Orihuela-Campos and Hiro-O Ito :
Modulation of Mucosal Immune Response by Bacterial Lipopolysaccharide in Nasal Vaccination Model,
第61回日本口腔衛生学会・総会, May 2012.
28. Makoto Fukui, SA Mulyatno, Masaki GOTO, Kaname Miki, RC Orihuela-Campos, Kosuke Kataoka, 林田 秀明, 北村 雅保, 川崎 浩二, 関田 孝晴, 中里 未央, 前田 隆浩, 齋藤 俊行 and Hiro-O Ito :
ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性-第二報-,
第61回日本口腔衛生学会・総会, May 2012.
29. Masaaki Yokoyama, Makoto Fukui, Tomoaki Honna, Natsuko Takamatsu, Kaname Masuda and Hiro-O Ito :
口腔清潔度の指標としての唾液中総細菌数,
Journal of Dental Health, Vol.57, No.5, 692, Oct. 2007.
30. Natsuko Takamatsu, Kaname Masuda, Makoto Fukui, Masaaki Yokoyama, Masami Yoshioka and Hiro-O Ito :
歯根面う蝕のリスクファクター調査,
Journal of Dental Health, Vol.57, No.4, 423, Aug. 2007.
31. Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kaname Masuda, Daisuke Hinode and Hiro-O Ito :
学校歯科健診における歯肉炎の評価についての考察,
Journal of Dental Health, Vol.56, No.5, 723, Oct. 2006.
32. Makoto Fukui, Masami Yoshioka, Tomoaki Honna, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Nozomi Yokoyama, Kaname Masuda, Daisuke Hinode and Ryo Nakamura :
フッ化物洗口実施校におけるう蝕予防効果─歯群別分析および乳歯う蝕と永久歯う蝕の関連性についての分析─,
Journal of Dental Health, Vol.55, No.4, 423, Aug. 2005.
33. Masami Yoshioka, Kaname Masuda, Nozomi Yokoyama, Masaaki Yokoyama, Shin-ichi Tanabe and Daisuke Hinode :
Peptostreptococcus microsのサイトカイン産生誘導能に対する酵素の関与,
Journal of Dental Health, Vol.55, No.4, 371, Aug. 2005.
34. Makoto Fukui, Kaname Masuda, Kanako Tamatani, Tomoaki Honna and Daisuke Hinode :
Relationship between periodontal conditions and sIgA directed to microbial GroEL.,
Journal of Dental Research, Nov. 2004.
35. Daisuke Hinode, Makoto Fukui, Shin-ichi Tanabe, Tomoaki Honna, Kaname Masuda and Masami Yoshioka :
歯周病原性細菌 Actinobacillus actinomycetemcomitans 由来 GroELとヒトファイブロネクチンの分子相同性,
Journal of Dental Health, Vol.54, No.4, 451, Sep. 2004.
36. Masaaki Yokoyama, Kaname Masuda, Nozomi Yokoyama, Kanako Tamatani, Masami Yoshioka and Daisuke Hinode :
女性ホルモンが歯周病原細菌Campylobacter rectus及びヒト歯肉線維芽細胞に及ぼす影響,
Journal of Dental Health, Vol.54, No.4, 452, Aug. 2004.
37. Kaname Masuda, Nozomi Yokoyama, Masami Yoshioka, Shin-ichi Tanabe, Tomoaki Honna, Daisuke Hinode and Ryo Nakamura :
Expression of Bradykiin B1 receptor mRNA in Human Gingival Fibroblast,
Journal of Dental Research, Vol.82, No.Special Issue C, C-436, Dec. 2003.
38. Kanako Tamatani, Kaname Masuda, Masaaki Yokoyama, 嶋田 順子, Tomoaki Honna, Daisuke Hinode and Ryo Nakamura :
Bacteroides forsythusの産生するトリプシン様酵素の性質,
Journal of Dental Health, Vol.51, No.4, 548-549, Sep. 2001.
39. Kaname Masuda, Masami Yoshioka, Makoto Fukui, 赤木 毅 and Kanako Tamatani :
Localization of Arginine Carboxypeptidase in Porphyromonas gingivalis,
Journal of Dental Research, Dec. 2000.
40. Tsuyoshi Akagi, Daisuke Hinode, Kaname Masuda, Shin-ichi Tanabe, Makoto Fukui, Masami Yoshioka and Ryo Nakamura :
Campylobacter rectus とHelicobacter pylori の共通抗原,
Journal of Dental Health, Vol.50, No.4, 592-593, Sep. 2000.
41. Kaname Masuda, Tsuyoshi Akagi, Junko Shimada, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura :
Porphyromonas gingivalis の産生するアルギニンカルボキシペプチダーゼの遺伝子解析,
Journal of Dental Health, Nov. 1999.

Et cetera, Workshop:

1. Chen Shu, Naofumi Tamaki, Kaname Miki and Hiro-O Ito :
Resveratrol attenuates 5-FU-induced cytotoxic reaction by inhibiting NF-kB and promoting f Nrf2 translocation to the nucleus in the HaCaT cell model,
2019 Tokushima Bioscience Retreat, Sep. 2019.
2. Naofumi Tamaki, 陳 舒, Yasusei Kudo, Kaname Miki, Naozumi Ishimaru and Hiro-O Ito :
実験的口腔粘膜モデルにおけるレスベラトロールの抗酸化・抗炎症効果,
第38回分子病理研究会, Jul. 2019.
3. Kaname Masuda, Shin-ichi Tanabe, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura :
Purification of Characterization of Arginine Carboxypeptidase Produced by Porphyromonas gingivalis,
Jul. 2001.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Antioxidant Activity of Cat's claw Extract as Natural Herb and its Preventive Effects on Periodontal Disease (Project/Area Number: 16K11859 )
  • 天然ペプチドライブラリーからのカンジダ菌定着抑制物質の検索 (Project/Area Number: 19592406 )
  • Search for inhibitory structures against adhesions of bacteria : construction and application of designed peptide libraries intended for prevention of infective endoearditis (Project/Area Number: 18390569 )
  • The prediction of periodontal condition by the measurement of the antibody titers directed to heat shock proteins (Project/Area Number: 12557184 )
  • Arginine Catabolism and Its Role in Pathogenecity by Periodontopathogenic Bacteria (Project/Area Number: 12470461 )
  • ポルフィロモナス・ジンジバリスのアルギニンカルボキシペプチダーゼの病原性について (Project/Area Number: 10771186 )
  • Host responses against heat shock proteins from periodontopathogenic bacteria (Project/Area Number: 10470447 )
  • Self Defence Mechanism of Porphyromonas gingivalis and Its Periodontopathogenicity (Project/Area Number: 09470472 )
  • ポルフィロモナス・ジンジバリスの産生するアルギニンカルボキシペプチダーゼ (Project/Area Number: 08771958 )
  • Mechanisms of the Periodontal Tissue Destruction by Periodontopathogenic Bacteria (Project/Area Number: 07457510 )
  • Biological and antigenic characterization of trypsin-like proteases from periodontal pathogensis bacteria (Project/Area Number: 06671887 )
  • Development of a diagnostic tool for periodontal disease by utilizing the monoclonal antibody directed the specific protease from periodontopathogensis bacteria (Project/Area Number: 06557113 )
  • Search by Researcher Number (30243710)