Tokushima University / Educator and Researcher Directory --- Miki, Kaname

Personal Web Page

https://researchmap.jp/read0017456 (researchmap)

Field of Study

○	Preventive Dentistry

Subject of Study

○	天然ハーブを用いた口腔内環境改善に関する研究 (ヒト歯肉線維芽細胞, 天然ハーブ, 歯周病, 慢性炎症, 組織修復)

Book / Paper

Academic Paper (Judged Full Paper):

1.	Shu Chen, Naofumi Tamaki, Yasusei Kudo, Takaaki Tsunematsu, Kaname Miki, Naozumi Ishimaru and Hiro-O Ito : Protective effects of resveratrol against 5-fluorouracil-induced oxidative stress and inflammatory responses in human keratinocytes., Journal of Clinical Biochemistry and Nutrition, Vol.69, No.3, 238-246, 2021. (Summary) -acetylcysteine reduced ROS levels without affecting the expression of pro-inflammatory cytokines. Resveratrol might be useful for preventing 5-FU-induced adverse effects by activating anti-oxidant and anti-inflammatory responses. (Tokushima University Institutional Repository) ● Metadata: 116380 (Link to Publication Site) ● Publication site (DOI): 10.3164/jcbn.21-23 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34857985 ● Search Scopus @ Elsevier (PMID): 34857985 ● Search Scopus @ Elsevier (DOI): 10.3164/jcbn.21-23 (Tokushima University Institutional Repository: 116380, DOI: 10.3164/jcbn.21-23, PubMed: 34857985)
2.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Rie Mukai, Makoto Fukui, Kaname Miki, Junji Terao and Hiro-O Ito : Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts., Journal of Clinical Biochemistry and Nutrition, Vol.56, No.3, 220-227, 2015. (Summary) In periodontitis, production of reactive oxygen species (ROS) by neutrophils induces oxidative stress and deteriorates surrounding tissues. Antioxidants reduce damage caused by ROS and are used to treat diseases involving oxidative stress. This study summarizes the different effects of resveratrol, quercetin, and N-acetylcysteine (NAC) on human gingival fibroblasts (HGFs) under oxidative stress induced by hydrogen peroxide. Real-time cytotoxicity analyses reveals that resveratrol and quercetin enhanced cell proliferation even under oxidative stress. Of the antioxidants tested, resveratrol is the most effective at inhibiting ROS production. HGFs incubated with resveratrol and quercetin up-regulate the transcription of type I collagen gene after 3 h, but only resveratrol sustained this up-regulation for 24 h. A measurement of the oxygen consumption rate (OCR, mitochondrial respiration) shows that resveratrol generates the highest maximal respiratory capacity, followed by quercetin and NAC. Simultaneous measurement of OCR and the extracellular acidification rate (non-mitochondrial respiration) reveals that resveratrol and quercetin induce an increase in mitochondrial respiration when compared with untreated cells. NAC treatment consumes less oxygen and enhances more non-mitochondrial respiration. In conclusion, resveratrol is the most effective antioxidant in terms of real-time cytotoxicity analysis, reduction of ROS production, and enhancement of type I collagen synthesis and mitochondrial respiration in HGFs. (Tokushima University Institutional Repository) ● Metadata: 109399 (Link to Publication Site) ● Publication site (DOI): 10.3164/jcbn.14-129 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26060353 ● Summary page in Scopus @ Elsevier: 2-s2.0-84929618900 (Tokushima University Institutional Repository: 109399, DOI: 10.3164/jcbn.14-129, PubMed: 26060353, Elsevier: Scopus)
3.	Masaaki Yokoyama, Makoto Fukui, Kaname Masuda, Natsuko Takamatsu, Jurou Okada, 裕光武部, Kosuke Kataoka and Hiro-O Ito : リアルタイム定量PCR(qPCR)法による唾液中の総細菌数の測定口腔清潔度の指標としての試み, Journal of Dental Health, Vol.59, No.3, 183-189, 2009. (Summary) The state of oral hygiene has been evaluated by employing various indices, such as the Oral Hygiene Index, Plaque Index, Patient Hygiene Performance, and Plaque Control Record (O'Leary's PCR). Measuring the scores of these indices is time- and labor-consuming, requiring manual reading and recording by professionals, standardization of examination methods. In contrast, measuring the total number of bacteria in saliva using quantitative real-time PCR (qPCR) allows the straightforward collection and storage of samples, making it possible to measure many samples at the same time. This technique facilitates the quantification of the number of bacteria within a shorter time than the culture method. In the present study, the total number of bacteria measured by qPCR was found to be significantly decreased (p<0.05) in stimulated whole saliva collected from 5 volunteers by chewing paraffin after tooth cleaning. These findings were in agreement with the decreases shown by Greene's Debris Index and O'Leary's PCR values. There was a significant correlation (r=0.55, p<0.01) between the salivary bacterial counts measured by qPCR from 81 subjects before and after a 4-month interval. These findings suggest that it is possible to measure the total number of bacteria in saliva using qPCR. This technique is convenient and is suggested to be applicable for assessing the oral hygiene status in the future. (Keyword) *Polymerase Chain Reaction (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679981008896 (CiNii: 1390282679981008896)
4.	Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Nozomi Yokoyama, Kaname Masuda, Daisuke Hinode and Ryo Nakamura : The Effects of Supervised Fluoride Mouth Rinsing on Dental Caries Development : Analyses of Caries Development by Tooth Type and of the Relationship between Deciduous Tooth Caries and Permanent Tooth Caries, Journal of Dental Health, Vol.55, No.5, 552-558, 2005. (Summary) In 1993, a daily fluoride mouth rinsing program and biannual oral examination were started at the nursery school, elementary school and junior high school of the K District, Tokushima Prefecture. In this study, the longitudinal change of caries development in elementary school students was evaluated. Caries development by tooth type in schoolchildren of the 6th grade was evaluated, and furthermore, the relationship between deciduous tooth caries in 1st grade students and caries development in permanent teeth in 6th grade students was also elucidated. After starting the daily fluoride mouth rinsing program, caries development in the permanent teeth of the low grade children of the elementary school began to decrease first, followed by that of the high grade children, and then, the junior high school students. It was revealed that the strong suppression of caries development in the 1st molar was reflected in a decrease in total caries development in the 6th grade schoolchildren. In addition, a significant relationship between DMFT in the 6th grade schoolchildren and the number of deciduous tooth caries or the number of deciduous teeth in the 1st grade schoolchildren was detected. These results suggest that a fluoride mouth rinsing program before school age is effective for caries prevention in the 1st molar, but, in order to effectively prevent permanent tooth caries, a high risk strategy is needed for children with deciduous tooth caries. (Keyword) Supervised fluoride mouth rinsing / Caries prevention / Analysis by tooth type / The relationship of the deciduous teeth caries to the permanent teeth caries (Link to Publication Site) ● Publication site (DOI): 10.5834/jdh.55.5_552 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205003730816 ● Search Scopus @ Elsevier (DOI): 10.5834/jdh.55.5_552 (DOI: 10.5834/jdh.55.5_552, CiNii: 1390001205003730816)
5.	Masaaki Yokoyama, Daisuke Hinode, Kaname Masuda, Masami Yoshioka and Daniel Grenier : Effect of female sex hormones on Campylobacter rectus and human gingival fibroblasts, Oral Microbiology and Immunology, Vol.20, No.4, 239-243, 2005. (Summary) Recent studies have suggested a relationship between maternal Campylobacter rectus infections and preterm low birth weight. The purpose of this study was to investigate the effect of female sex hormones, estradiol and progesterone, on C. rectus and human gingival fibroblasts (HGF). The growth of C. rectus was significantly enhanced by incorporating either estradiol or progesterone in the culture medium. The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women. In addition, a significantly higher secretion of VEGF by HGF treated with the combination of C. rectus and estradiol was observed in comparison with a treatment with C. rectus alone. Stimulation of HGF with VEGF resulted in production of IL-6 and IL-8 in a dose-dependent manner. The capacity of female sex hormones to enhance both C. rectus growth and VEGF, IL-6, and IL-8 production by HGF has the potential to contribute to periodontal disease progression during pregnancy. (Keyword) Campylobacter rectus / female sex hormones / human gingival fibroblasts / vascular endothelial growth factor (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1399-302X.2005.00222.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15943769 ● Search Scopus @ Elsevier (PMID): 15943769 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1399-302X.2005.00222.x (DOI: 10.1111/j.1399-302X.2005.00222.x, PubMed: 15943769)
6.	Masami Yoshioka, Nozomi Yokoyama, Kaname Masuda, Honna Tomoaki, Daisuke Hinode, Ryo Nakamura, Rouabhia Mahmoud, Mayrand Denis and Grenier Daniel : Effect of hydroxamic acid-based MMP inhibitors on human gingival cells and Porphyromonas gingivalis, Journal of Periodontology, Vol.74, No.8, 1219-1224, 2003. (Summary) Matrix metalloproteinases (MMPs) are considered to play key roles in tissue destruction during periodontitis. In this study, we evaluated the cytotoxicity of hydroxamic acid-based MMP inhibitors (ONO-4817, ONO-MI1-514, and ONO-MI1-570), and their inhibitory effects on MMP-2 and -9 activities and growth of Porphyromonas gingivalis. Human gingival fibroblasts (HGF) and human gingival epithelial cells (HGE) were incubated with test inhibitors prior to investigating cell viability, cell proliferation, and mRNA expression for MMP-2 and -9. Gelatin zymography and a colorimetric MMP assay were performed to study the inhibitory effects on MMP-2 and -9 activities derived from HGF and HGE, respectively. The effect of MMP inhibitors on keratinocyte migration and P. gingivalis growth was also tested. Cell viability was not affected by any of the inhibitors at a final concentration of 50 microM, nor was cell proliferation at 20 microM. All inhibitors clearly inhibited MMP-2 produced by HGF and MMP-9 produced by HGE in a dose-dependent manner. No change was found in mRNA expression of MMPs by gingival cells treated with the inhibitors. ONO-4817 and ONO-MI1-514 inhibited keratinocyte migration. ONO-4817 showed a slightly inhibitory effect on the growth of P. gingivalis. Data obtained in this study support the potential use of the three MMP inhibitors for the prevention and treatment of periodontal disease. (Keyword) cells / gingival epithelial / cytotoxicity / fibroblasts / gingival / hydroxamic acids / metalloproteinase tissue inhibitors / matrix / metalloproteinases / Porphyromonas gingivalis (Link to Publication Site) ● Publication site (DOI): 10.1902/jop.2003.74.8.1219 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14514237 ● Search Scopus @ Elsevier (PMID): 14514237 ● Search Scopus @ Elsevier (DOI): 10.1902/jop.2003.74.8.1219 (DOI: 10.1902/jop.2003.74.8.1219, PubMed: 14514237)
7.	Kaname Masuda, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Purification and characterization of arginine carboxypeptidase produced by Porphyromonas gingivalis, Infection and Immunity, Vol.70, No.4, 1807-1815, 2002. (Summary) Arginine carboxypeptidase was isolated from the cytoplasm of Porphyromonas gingivalis 381 and purified by DEAE-Sephacel column chromatography, followed by high-performance liquid chromatography on DEAE-5PW and TSK G2000SW(XL). Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified enzyme revealed the presence of three major bands at 42, 33, and 32 kDa with identical N-terminal sequences. By Western blotting analysis and immunoelectron microscopy, the arginine carboxypeptidase was found to be widely distributed in the cytoplasm and on the surface of the outer membrane. The open reading frame corresponding to the N-terminal amino acids of the arginine carboxypeptidase was detected by a search of the sequence of the P. gingivalis W83 genome. This sequence showed homology with mammalian carboxypeptidases (M, N, and E/H) and included a zinc-binding region signature, suggesting that the enzyme is a member of the zinc carboxypeptidase family. The purified enzyme was inhibited by EGTA, o-phenanthroline, DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, and some metal ions, such as Cu(2+), Zn(2+), and Cd(2+). On the other hand, Co(2+) activated the enzyme. The enzyme released arginine and/or lysine from biologically active peptides containing these amino acids at the C terminus but did not cleave substrates when proline was present at the penultimate position. These results indicate that the arginine carboxypeptidase produced by P. gingivalis is an exo type of metallocarboxypeptidase. This enzyme may function to release arginine in collaboration with an arginine aminopeptidase, e.g., Arg-gingipain, to obtain specific amino acids from host tissues during the growth of P. gingivalis. (Keyword) 3-Mercaptopropionic Acid / Amino Acid Sequence / Base Sequence / Carboxypeptidase B2 / Hydrogen-Ion Concentration / Molecular Sequence Data / Molecular Weight / Porphyromonas gingivalis / Substrate Specificity (Link to Publication Site) ● Publication site (DOI): 10.1128/IAI.70.4.1807-1815.2002 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11895942 ● Search Scopus @ Elsevier (PMID): 11895942 ● Search Scopus @ Elsevier (DOI): 10.1128/IAI.70.4.1807-1815.2002 (DOI: 10.1128/IAI.70.4.1807-1815.2002, PubMed: 11895942)
8.	Kaname Masuda, Tomita Koji, Hayashi Hiroyuki, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Consumption of Peptide-derived Arginine by a Periodontopathogenic Bacterium, Porphyromonas gingivalis, Anaerobe, Vol.7, No.4, 209-217, 2001. (Link to Publication Site) ● Publication site (DOI): 10.1006/anae.2001.0383 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0035177880 (DOI: 10.1006/anae.2001.0383, Elsevier: Scopus)
9.	Masami Yoshioka, Kaname Masuda, Daisuke Hinode, 林裕行 and Ryo Nakamura : 歯周病原性細菌のプロテアーゼに対するモノクローナル抗体を利用した歯周病診断の試み, Journal of Dental Health, Vol.49, No.1, 71-78, 1999.
10.	Daisuke Hinode, Masami Yoshioka, Shin-ichi Tanabe, Osamu Miki, Kaname Masuda and Ryo Nakamura : The GroEL-like protein from Campylobacter rectus: immunological characterization and interleukin-6 and -8 induction in human gingival fibroblast, FEMS Microbiology Letters, Vol.167, No.1, 1-6, 1998.
11.	Masami Yoshioka, 大塚千亜紀, Kanako Tamatani, Kaname Masuda, 三木修, 林祐行 and Ryo Nakamura : Porphyromonas gingivalisの産生するアルギニン代謝関連酵素と細胞凝集活性との関連について, Journal of Dental Health, Vol.47, 83-88, 1997.
12.	Daisuke Hinode, Kaname Masuda, Masami Yoshioka, H Hayashi, R Nakamura, D Grenier and D Mayrand : Biological and antigenic characterization of three BApNA-hydrolyzing proteases from the culture supernatant of Porphyromonas gingivalis, Oral Microbiology and Immunology, Vol.11, No.1, 8-14, 1996. (Keyword) Porphyromonas gingiivalis / BApNA-hydrolyzing protease / periodontal disease / pathogenicity
13.	Daisuke Hinode, Kaname Masuda, Masami Yoshioka, Kiyoko Watanabe, Toshio Umemoto, Daniel Grenier, Denis Mayrand and Ryo Nakamura : Immunological characterization and localization of a Porphyromonas gingivalis BApNA-hydrolyzing protease possessing hemagglutinating activity, FEMS microbiology letters, Vol.131, No.2, 211-217, 1995. (Keyword) BA pNA-hydrolyzing protease / Porphyromonas gingivalis / Monoclonal antibody / Hemagglutinating activity / Periodonatal disease
14.	Daisuke Hinode, Kaname Masuda, Masami Yoshioka, Hiroyuki Hayashi and Ryo Nakamura : Purification of an Extracellular Soluble Protease Possessing BApNA Hydrolytic Activity from Culture Supernatants of Porphyromonas gingivalis, Journal of Dental Health, Vol.44, No.3, 308-314, 1994. (Keyword) Porphyromonas gingiivalis / Soluble trypsin-like protease / Periodontal disease

Academic Paper (Unrefereed Paper):

1.	Kaname Miki, Naofumi Tamaki and Hiro-O Ito : Utility of Natural Herbs -Focusing on Dental Field Use, Journal of Oral Health and Biosciences, Vol.32, No.1, 16-25, 2019. (Keyword) Natural herbs / periodontitis / systemic disease / Cat's claw (Tokushima University Institutional Repository) ● Metadata: 113665 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.32.1_16 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390564238105416064 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.32.1_16 (Tokushima University Institutional Repository: 113665, DOI: 10.20738/johb.32.1_16, CiNii: 1390564238105416064)

Proceeding of International Conference:

1.	Makoto Fukui, Kaname Miki, Kitamura Masayasu, Hayashida Hideaki, Kawasaki Koji, Rita Cristina Orihuela Campos, Naofumi Tamaki, Maeda Takahiro, Saito Toshiyuki and Hiro-O Ito : Porphyromonas gingivalis infection may affect anti-atheroschlerotic antibody to phosphorylcholine., The 12th International Conference of Asia Academy of Preventive Dentistry, May 2016.
2.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Balance is the key: resveratrol revert oxidative stress conditions in gingival fibroblasts, 第93回IADR, Mar. 2015.
3.	Makoto Fukui, Kaname Miki, Naofumi Tamaki and Hiro-O Ito : Relationship between atherosclerosis and anti-phosphorylcholine antibodies in saliva and plasma, ICAAPD, ウランバートル, Sep. 2012.
4.	Masami Yoshioka, Kaname Masuda, Nozomi Yokoyama, Masaaki Yokoyama, Shin-ichi Tanabe, Daisuke Hinode and Daniel Grenier : Contribution of Peptostreptococcus Micros proteases in cytokine response by human gingival fibroblasts, 4th General Annual Meeting of the International Conference on Protease Inhibitors, Quebec City, Oct. 2005.
5.	Nozomi Yokoyama, Kaname Masuda, Masami Yoshioka, Masaaki Yokoyama, Daisuke Hinode and Ryo Nakamura : Effect of Hydroxamic Acid-Based MMP Inhibitors on Human Gingival Cells, 80th General session of the International Association for Dental Research, San Diego, Mar. 2002. (Keyword) MMP / gingiva
6.	Kaname Masuda, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Characterization of Arginine Carboxypeptidase from Porphryomonas gingivalis, Journal of Dental Research, Vol.78, Vancouver, Mar. 1999.
7.	Daisuke Hinode, Shin-ichi Tanabe, Osamu Miki, Kaname Masuda, Masami Yoshioka and Ryo Nakamura : Interleukin Secretion by the GroEL-like Protein from Campylobacter rectus., Journal of Dental Research, Vol.78, No.Special Issue, 418, Vancouver, Canada, Mar. 1999.
8.	Daisuke Hinode, Kaname Masuda, Masami Yoshioka, H Hayashi, R Nakamura, D Grenier and D Mayrand : Characterization of three BApNA hydrolyzing proteases from Porphyromonas gingivalis, 24th Annual meeting of the American Association for Dental Research, San Antonio, U.S.A, Mar. 1995.

Proceeding of Domestic Conference:

1.	Kaname Miki : 歯科に役立つメディカルアロマセラピー基礎編, 四国歯学会第63回例会, Mar. 2024.
2.	Kaname Miki, Naofumi Tamaki and Hiro-O Ito : ヒト歯肉線維芽細胞を用いた天然ハーブ・キャッツクロー抽出物の創傷治癒に及ぼす効果, 第72回口腔衛生学会総会, May 2023.
3.	長田卓也, 宮生竜生, Naofumi Tamaki, Kaname Miki and Hiro-O Ito : MA-Tを用いた洗口が口臭と口腔細菌に及ぼす効果, 四国歯学会第61回例会, Mar. 2023.
4.	Naofumi Tamaki, Kaname Miki and Hiro-O Ito : ヒト歯肉上皮細胞における抗癌剤による有害事象へのレスベラトロールの効果, 日本口腔衛生学会, May 2022.
5.	神田和弘, 福永隼也, Naofumi Tamaki, Kaname Miki and Hiro-O Ito : CHX洗口液の口臭に対する効果, Shikoku Dental Research, Mar. 2022.
6.	Kaname Miki, CHEN SHU, Naofumi Tamaki and Hiro-O Ito : ヒト歯肉線維芽細胞における天然ハーブ・キャッツクロー抽出物の抗炎症効果, 第32回近畿・中国・四国日本口腔衛生学会・総会, Oct. 2021.
7.	Kaname Miki, CHEN SHU, Naofumi Tamaki and Hiro-O Ito : 天然ハーブ・キャッツクローのP. gingivalis LPS 誘発性サイトカイン発現に対する抑制作用, 第24回日本歯科医学会学術大会, Sep. 2021.
8.	Naofumi Tamaki, CHEN SHU, Kaname Miki and Hiro-O Ito : 口腔粘膜炎のin vitro モデルにおけるレスベラトロールの抗酸化・抗炎症効果, 第70回日本口腔衛生学会総会, May 2021.
9.	Shibyoh Oh, Akari Watanabe, Miwa Matsuyama, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : ATP測定法による口腔内細菌数の評価, 第30回近畿・中国・四国口腔衛生学会総会, Sep. 2019. (Keyword) ATP測定 / 口腔内細菌
10.	大毛健一郎, 野上幸裕, Naofumi Tamaki, Kaname Miki and Hiro-O Ito : 口腔内清掃による口臭値と口腔内細菌数指標の変化, 第55回四国歯学会, Sep. 2019.
11.	Chen Shu, Naofumi Tamaki, Kaname Miki and Hiro-O Ito : Preventive effects of resveratrol against 5-fluorouracil induced cytotoxicity in HaCaT cells, 第68回日本口腔衛生学会・総会, May 2019.
12.	Kaname Miki, Makoto Fukui, CHEN SHU, Naofumi Tamaki and Hiro-O Ito : 天然ハーブ・キャッツクロー抽出物の歯周病原菌に対する抗菌効果, 第29回近畿中国四国口腔衛生学会, Sep. 2018.
13.	Kaname Miki : 天然ハーブの有用性ー歯科の領域を中心にー, 第53回例会四国歯学会, Jul. 2018.
14.	Makoto Fukui, CHEN SHU, Kaname Miki, Naofumi Tamaki, 福田功 and Hiro-O Ito : 歯肉炎症の評価における3種の唾液潜血検査の有用性の検討第28回近畿・中国・四国口腔衛生学会総会 2017年10月1日広島大学歯学部(広島市), 第28回近畿・中国・四国口腔衛生学会総会, Oct. 2017.
15.	Makoto Fukui, CHEN SHU, Kaname Miki, Naofumi Tamaki, 福田功 and Naofumi Tamaki : 歯肉炎症の評価における3種の唾液潜血検査の有用性の検討, 第28回近畿・中国・四国口腔衛生学会・総会, Oct. 2017.
16.	Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : 唾液潜血検査の判定を妨害する因子の検索, 第27回近畿・中国・四国口腔衛生学会・総会, Oct. 2016.
17.	Makoto Fukui, Kaname Miki, K Kitamura, H Hayashida, K Kawasaki, Rita Cristina Orihuela Campos, Naofumi Tamaki, T Maeda, T Saito and Hiro-O Ito : Atherosclerosis-preventive activity of anti-phosphorylcholine antibody may be interfered by infection with Porphyromonas gingivalis : The Nagasaki Islands study, 63rd Annual Meeting of the Japanese Association of Dental Research, Oct. 2015.
18.	水野昭彦, 松尾亮, 鈴木雅博, Naofumi Tamaki, Makoto Fukui, Kaname Miki, 松瀬亮一 and Hiro-O Ito : 市民検診と糖尿病患者データにおける歯肉溝浸出液バイオマーカーの比較検討, 第64回口腔衛生学会総会, May 2015.
19.	Naofumi Tamaki, Rita Cristina Orihuela Campos, Makoto Fukui, Kaname Miki and Hiro-O Ito : 水素水の抗酸化・抗炎症作用の検討, 第64回口腔衛生学会総会, May 2015.
20.	Makoto Fukui, 岡田寿郎, Kaname Miki, Naofumi Tamaki and Hiro-O Ito : ``標準的な成人歯科健診プログラム・保健指導マニュアル''に基づいた歯科保健事業の効果について, 第64回口腔衛生学会総会, May 2015.
21.	松尾亮, 水野昭彦, 鈴木雅博, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : 歯肉溝浸出液バイオマーカーと血液データの比較検討, 第49回日本成人病(生活習慣病)学会, Jan. 2015.
22.	Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : Levels of various cytokines in human saliva from generally healthy individuals., 62nd Annual Meeting of the Japanese Association for Dental Research, Dec. 2014.
23.	Kenjiroh Takao, Mamiko Nii, Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : 歯肉炎症の客観的・定量的診断を目指した市販免疫クロマトグラフィー唾液潜血テストの改良, 第25回近畿・中国・四国口腔衛生学会総会, Oct. 2014.
24.	水野昭彦, 松尾亮, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : 歯肉溝浸出液バイオマーカーと血液データの比較, 第25回近畿・中国・四国口腔衛生学会総会, Oct. 2014.
25.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Effects of three different antioxidants on human gingival fibroblasts exposed to oxidative stress, 2014 Tokushima Bioscience retreat, Sep. 2014.
26.	Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : 健常者における唾液中サイトカインプロファイルの解析, 第63回口腔衛生学会総会, May 2014.
27.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Effects of three antioxidant compounds on human gingival fibroblasts under oxidative stress, 第63回口腔衛生学会総会, May 2014.
28.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Effects of different antioxidants on human gingival fibroblasts under oxidative stress, 第5回心・血管クラスターミニリトリート, Jan. 2014.
29.	Makoto Fukui, Kaname Miki, Naofumi Tamaki and Hiro-O Ito : 唾液中サイトカインと口腔健康状態の関連性, 第24回近畿・中国・四国口腔衛生学会総会, Oct. 2013.
30.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Effects of different antioxidants on the biological properties of human gingival fibroblasts response toward ROS, Tokushima Bioscience retreat, Sep. 2013.
31.	Rita Cristina Orihuela Campos, Naofumi Tamaki, Makoto Fukui, Kaname Miki and Hiro-O Ito : Real time xCELLigence analysis of antioxidant agents on human gingival fibroblast cells viability, 第62回日本口腔衛生学会総会, May 2013.
32.	Makoto Fukui, Kaname Miki, Rita Cristina Orihuela Campos, Naofumi Tamaki and Hiro-O Ito : 健常者における唾液中サイトカイン分析, 第62回日本口腔衛生学会・総会, May 2013.
33.	Makoto Fukui, Naofumi Tamaki, Kaname Miki and Hiro-O Ito : 動脈硬化リスク評価のための唾液・血液中の抗ホスホリルコリン抗体の測定, 心血管クラスターリトリート, Jan. 2013.
34.	Makoto Fukui, Kaname Miki, Naofumi Tamaki and Hiro-O Ito : 動脈硬化リスク評価のための唾液・血液中の抗ホスホリルコリン抗体の測定, 第5回日本口腔検査学会総会・学術大会, Aug. 2012.
35.	SA Mulyatno, Kosuke Kataoka, Makoto Fukui, Kaname Miki, RC Orihuela-Campos and Hiro-O Ito : Modulation of Mucosal Immune Response by Bacterial Lipopolysaccharide in Nasal Vaccination Model, 第61回日本口腔衛生学会・総会, May 2012.
36.	Makoto Fukui, SA Mulyatno, Masaki GOTO, Kaname Miki, RC Orihuela-Campos, Kosuke Kataoka, 林田秀明, 北村雅保, 川崎浩二, 関田孝晴, 中里未央, 前田隆浩, 齋藤俊行 and Hiro-O Ito : ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性-第二報-, 第61回日本口腔衛生学会・総会, May 2012.
37.	Masaaki Yokoyama, Makoto Fukui, Tomoaki Honna, Natsuko Takamatsu, Kaname Masuda and Hiro-O Ito : 口腔清潔度の指標としての唾液中総細菌数, Journal of Dental Health, Vol.57, No.5, 692, Oct. 2007.
38.	Natsuko Takamatsu, Kaname Masuda, Makoto Fukui, Masaaki Yokoyama, Masami Yoshioka and Hiro-O Ito : 歯根面う蝕のリスクファクター調査, Journal of Dental Health, Vol.57, No.4, 423, Aug. 2007.
39.	Masami Yoshioka, Tomoaki Honna, Makoto Fukui, Masaaki Yokoyama, Shin-ichi Tanabe, Kaname Masuda, Daisuke Hinode and Hiro-O Ito : 学校歯科健診における歯肉炎の評価についての考察, Journal of Dental Health, Vol.56, No.5, 723, Oct. 2006.
40.	Makoto Fukui, Masami Yoshioka, Tomoaki Honna, Masaaki Yokoyama, Shin-ichi Tanabe, Kanako Tamatani, Nozomi Yokoyama, Kaname Masuda, Daisuke Hinode and Ryo Nakamura : フッ化物洗口実施校におけるう蝕予防効果─歯群別分析および乳歯う蝕と永久歯う蝕の関連性についての分析─, Journal of Dental Health, Vol.55, No.4, 423, Aug. 2005.
41.	Masami Yoshioka, Kaname Masuda, Nozomi Yokoyama, Masaaki Yokoyama, Shin-ichi Tanabe and Daisuke Hinode : Peptostreptococcus microsのサイトカイン産生誘導能に対する酵素の関与, Journal of Dental Health, Vol.55, No.4, 371, Aug. 2005.
42.	Makoto Fukui, Kaname Masuda, Kanako Tamatani, Tomoaki Honna and Daisuke Hinode : Relationship between periodontal conditions and sIgA directed to microbial GroEL., Journal of Dental Research, Nov. 2004.
43.	Daisuke Hinode, Makoto Fukui, Shin-ichi Tanabe, Tomoaki Honna, Kaname Masuda and Masami Yoshioka : 歯周病原性細菌 Actinobacillus actinomycetemcomitans 由来 GroELとヒトファイブロネクチンの分子相同性, Journal of Dental Health, Vol.54, No.4, 451, Sep. 2004.
44.	Masaaki Yokoyama, Kaname Masuda, Nozomi Yokoyama, Kanako Tamatani, Masami Yoshioka and Daisuke Hinode : 女性ホルモンが歯周病原細菌Campylobacter rectus及びヒト歯肉線維芽細胞に及ぼす影響, Journal of Dental Health, Vol.54, No.4, 452, Aug. 2004. (Keyword) 女性ホルモン / Campylobacter rectus / ヒト歯肉線維芽細胞
45.	Kaname Masuda, Nozomi Yokoyama, Masami Yoshioka, Shin-ichi Tanabe, Tomoaki Honna, Daisuke Hinode and Ryo Nakamura : Expression of Bradykiin B1 receptor mRNA in Human Gingival Fibroblast, Journal of Dental Research, Vol.82, No.Special Issue C, C-436, Dec. 2003.
46.	Kanako Tamatani, Kaname Masuda, Masaaki Yokoyama, 嶋田順子, Tomoaki Honna, Daisuke Hinode and Ryo Nakamura : Bacteroides forsythusの産生するトリプシン様酵素の性質, Journal of Dental Health, Vol.51, No.4, 548-549, Sep. 2001.
47.	Kaname Masuda, Masami Yoshioka, Makoto Fukui, 赤木毅 and Kanako Tamatani : Localization of Arginine Carboxypeptidase in Porphyromonas gingivalis, Journal of Dental Research, Dec. 2000.
48.	Tsuyoshi Akagi, Daisuke Hinode, Kaname Masuda, Shin-ichi Tanabe, Makoto Fukui, Masami Yoshioka and Ryo Nakamura : Campylobacter rectus とHelicobacter pylori の共通抗原, Journal of Dental Health, Vol.50, No.4, 592-593, Sep. 2000.
49.	Kaname Masuda, Tsuyoshi Akagi, Junko Shimada, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Porphyromonas gingivalis の産生するアルギニンカルボキシペプチダーゼの遺伝子解析, Journal of Dental Health, Nov. 1999.

Et cetera, Workshop:

1.	Chen Shu, Naofumi Tamaki, Kaname Miki and Hiro-O Ito : Protective effects of resveratrol against 5-FU-induced inflammatory responses in HaCaT cells., 13, Jan. 2021.
2.	Chen Shu, Naofumi Tamaki, Kaname Miki and Hiro-O Ito : Resveratrol attenuates 5-FU-induced cell damage via activation of Nrf2 antioxidant pathway, 2020 69, Apr. 2020.
3.	Chen Shu, Naofumi Tamaki, Kaname Miki and Hiro-O Ito : Resveratrol attenuates 5-FU-induced cytotoxic reaction by inhibiting NF-kB and promoting f Nrf2 translocation to the nucleus in the HaCaT cell model, 2019 Tokushima Bioscience Retreat, Sep. 2019.
4.	Naofumi Tamaki, 陳舒, Yasusei Kudo, Kaname Miki, Naozumi Ishimaru and Hiro-O Ito : 実験的口腔粘膜モデルにおけるレスベラトロールの抗酸化・抗炎症効果, 第38回分子病理研究会, Jul. 2019.
5.	Kaname Masuda, Shin-ichi Tanabe, Masami Yoshioka, Daisuke Hinode and Ryo Nakamura : Purification of Characterization of Arginine Carboxypeptidase Produced by Porphyromonas gingivalis, Jul. 2001.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Antioxidant Activity of Cat's claw Extract as Natural Herb and its Preventive Effects on Periodontal Disease (Project/Area Number: 16K11859 )
天然ペプチドライブラリーからのカンジダ菌定着抑制物質の検索 (Project/Area Number: 19592406 )
Search for inhibitory structures against adhesions of bacteria : construction and application of designed peptide libraries intended for prevention of infective endoearditis (Project/Area Number: 18390569 )
The prediction of periodontal condition by the measurement of the antibody titers directed to heat shock proteins (Project/Area Number: 12557184 )
Arginine Catabolism and Its Role in Pathogenecity by Periodontopathogenic Bacteria (Project/Area Number: 12470461 )
ポルフィロモナス・ジンジバリスのアルギニンカルボキシペプチダーゼの病原性について (Project/Area Number: 10771186 )
Host responses against heat shock proteins from periodontopathogenic bacteria (Project/Area Number: 10470447 )
Self Defence Mechanism of Porphyromonas gingivalis and Its Periodontopathogenicity (Project/Area Number: 09470472 )
ポルフィロモナス・ジンジバリスの産生するアルギニンカルボキシペプチダーゼ (Project/Area Number: 08771958 )
Mechanisms of the Periodontal Tissue Destruction by Periodontopathogenic Bacteria (Project/Area Number: 07457510 )
Biological and antigenic characterization of trypsin-like proteases from periodontal pathogensis bacteria (Project/Area Number: 06671887 )
Development of a diagnostic tool for periodontal disease by utilizing the monoclonal antibody directed the specific protease from periodontopathogensis bacteria (Project/Area Number: 06557113 )
Search by Researcher Number (30243710)

Assistant Professor : Miki, Kaname

Research

Personal Web Page

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

Academic Paper (Unrefereed Paper):

Proceeding of International Conference:

Proceeding of Domestic Conference:

Et cetera, Workshop:

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)