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Research Activity

Field of Study

歯周病学
Endodontology

Subject of Study

歯周病における歯周組織細胞の作用
根尖性歯周炎の治癒メカニズム

Book / Paper

Book:

1. Koji Naruishi and Toshihiko Nagata :
ザ・ペリオドントロジー「歯周病と慢性腎臓病(CKD)」,
永末書店, Feb. 2019.
2. Timothy C Thompson, Saladihan A Tahir, Likun Li, Masami Watanabe, Koji Naruishi, Guang Yang and Ken-ichi Tabata :
Local and distant effects of caveolin-1 on prostate cancer tumor progression,
Springer Science + Business Media, Mar. 2011.
3. Timme L Terry, Fujita Tetsuo, Wang Hongyu, Koji Naruishi, Kadmon Dov and Thompson C Timothy :
Cytokine Gene Therapy for Genitourinary Cancer,
The Humana Press, 2007.

Academic Paper (Judged Full Paper):

1. Koji Naruishi :
Carotenoids and Periodontal Infection.,
Nutrients, Vol.12, No.1, E269, 2020.
(DOI: 10.3390/nu12010269,   PubMed: 31968635)
2. Kohei Nonaka, Mika Bandou, Eijiro Sakamoto, Yuji Inagaki, Koji Naruishi, Hiromichi Yumoto and Jun-ichi Kido :
6-Shogaol inhibits advanced glycation end-products-induced IL-6 and ICAM-1 expression by regulating oxidative responses in human gingival fibroblasts,
Molecules, Vol.24, No.20, e3705, 2019.
(DOI: 10.3390/molecules24203705,   PubMed: 31619000,   Elsevier: Scopus)
3. Masami Ninomiya, Mari Hashimoto, Kouji Yamanouchi, Yoshiaki Fukumura, Toshihiko Nagata and Koji Naruishi :
Relationship of oral conditions to the incidence of infective endocarditis in periodontitis patients with valvular heart disease: a cross-sectional study.,
Clinical Oral Investigations, 2019.
(Tokushima University Institutional Repository: 113773,   DOI: 10.1007/s00784-019-02973-2,   PubMed: 31197658,   Elsevier: Scopus)
4. Eijiro Sakamoto, Jun-ichi Kido, Ryosuke Takagi, Yuji Inagaki, Koji Naruishi, Toshihiko Nagata and Hiromichi Yumoto :
Advanced glycation end-product 2 and Porphyromonas gingivalis lipopolysaccharide increase sclerostin expression in mouse osteocyte-like cells,
Bone, Vol.122, 22-30, 2019.
(DOI: 10.1016/j.bone.2019.02.001,   PubMed: 30735798)
5. Jung-Hwan Lew, Koji Naruishi, Yukari Kajiura, Yasufumi Nishikawa, Takahisa Ikuta, Jun-ichi Kido and Toshihiko Nagata :
High Glucose-Mediated Cytokine Regulation in Gingival Fibroblasts and THP-1 Macrophage: a Possible Mechanism of Severe Periodontitis with Diabetes.,
Cellular Physiology and Biochemistry, Vol.50, No.3, 973-986, 2018.
(Tokushima University Institutional Repository: 113370,   DOI: 10.1159/000494481,   PubMed: 30355945)
6. Koji Naruishi :
Association between oral frailty and geriatric conditions,
OBM Geriatrics, Vol.2, No.4, 2018.
(DOI: 10.21926/obm.geriatr.1804016)
7. Kohei Nonaka, Yukari Kajiura, Mika Bandou, Eijiro Sakamoto, Yuji Inagaki, JH Lew, Koji Naruishi, Takahisa Ikuta, Kaya Yoshida, Tesuo Kobayashi, Hiromasa Yoshie, Toshihiko Nagata and Jun-ichi Kido :
Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-kB pathways in human gingival fibroblasts,
Journal of Periodontal Research, Vol.53, No.3, 334-344, 2018.
(DOI: 10.1111/jre.12518,   PubMed: 29193068,   Elsevier: Scopus)
8. Koji Naruishi, Hiromichi Yumoto and Jun-ichi Kido :
Clinical effects of low body mass index on geriatric status in elderly patients.,
Experimental Gerontology, Vol.110, 86-91, 2018.
(DOI: 10.1016/j.exger.2018.05.017,   PubMed: 29842897)
9. Koji Naruishi, Yasufumi Nishikawa, Jun-ichi Kido, Akihiro Fukunaga and Toshihiko Nagata :
Relationship of aspiration pneumonia to cognitive impairment and oral condition: a cross-sectional study.,
Clinical Oral Investigations, Vol.22, No.7, 2575-2580, 2018.
(DOI: 10.1007/s00784-018-2356-7,   PubMed: 29388021)
10. Yukari Kajiura, Yasufumi Nishikawa, Hwan Jung Lew, Jun-ichi Kido, Toshihiko Nagata and Koji Naruishi :
b-carotene suppresses Porphyromonas gingivalis lipopolysaccharide-mediated cytokine production in THP-1 monocytes cultured with high glucose condition.,
Cell Biology International, Vol.42, No.1, 105-111, 2018.
(Tokushima University Institutional Repository: 112503,   DOI: 10.1002/cbin.10873,   PubMed: 28906038)
11. Koji Naruishi and Yasufumi Nishikawa :
Swallowing impairment is a significant factor for predicting life prognosis of elderly at the end of life.,
Aging Clinical and Experimental Research, Vol.30, No.1, 77-80, 2018.
(DOI: 10.1007/s40520-017-0756-1,   PubMed: 28391586)
12. Chie Mihara-Wada, Hiroyuki Seto, Hirofumi Ohba, Kaku Tokunaga, Jun-ichi Kido, Toshihiko Nagata and Koji Naruishi :
Local administration of calcitonin inhibits alveolar bone loss in an experimental periodontitis in rats.,
Biomedicine & Pharmacotherapy, Vol.97, No.1, 765-770, 2018.
(DOI: 10.1016/j.biopha.2017.10.165,   PubMed: 29107933)
13. Yuka Hiroshima, Eijiro Sakamoto, Kaya Yoshida, Kaori Abe, Koji Naruishi, Takenori Yamamoto, Yasuo Shinohara, Jun-ichi Kido and Carolyn L Geczy :
Advanced glycation end-products and Porphyromonas gingivalis lipopolysaccharide increase calprotectin expression in human gingival epithelial cells.,
Journal of Cellular Biochemistry, Vol.119, No.2, 1591-1603, 2018.
(DOI: 10.1002/jcb.26319,   PubMed: 28771806)
14. Jun-ichi Kido, Shinya Murakami, Masahiro Kitamura, Manabu Yanagita, Koichi Tabeta, Kazuhisa Yamazaki, Hiromasa Yoshie, Hisashi Watanabe, Yuichi Izumi, Reiko Suda, Matsuo Yamamoto, Hideki Shiba, Tsuyoshi Fujita, Hidemi Kurihara, Mitsuharu Mizuno, Akihiro Mishima, Nobumasa Kawahara, Kazuhiro Hashimoto, Koji Naruishi and Toshihiko Nagata :
Useful Immunochromatographic Assay of Calprotectin in Gingival Crevicular Fluid for Diagnosis of Diseased Sites in Patients with Periodontal Diseases.,
Journal of Periodontology, 1-19, 2017.
(DOI: 10.1902/jop.2017.170206,   PubMed: 28875823)
15. Koji Naruishi :
Association between Oral Conditions and Returning Home after Discharge in Elderly Patients,
Geriatrics, Vol.2, No.3, 28, 2017.
(DOI: 10.3390/geriatrics2030028)
16. Yukari Kajiura, Hwan Jung Lew, Takahisa Ikuta, Yasufumi Nishikawa, Jun-ichi Kido, Toshihiko Nagata and Koji Naruishi :
Clinical Significance of GCF sIL-6R and Calprotectin to Evaluate the Periodontal Inflammation.,
Annals of Clinical Biochemistry, Vol.54, No.6, 664-670, 2017.
(DOI: 10.1177/0004563216680232,   PubMed: 27810997)
17. Chie Mihara-Wada, Koji Naruishi, Mika Bandou, Nishikawa Yasufumi, Jung-Hwan Lew, Eijiro Sakamoto, Ikuta Takahisa, Kono Kaoru, Yukari Kajiura, Hashimoto Mari, Yukiko Nakajima, Yuji Inagaki, Masami Ninomiya, Jun-ichi Kido and Toshihiko Nagata :
Post clinical clerkship-OSCEを見据えた歯周病科での模擬OSCEの概要,
Journal of Oral Health and Biosciences, Vol.29, No.2, 49-53, 2017.
(Tokushima University Institutional Repository: 111059)
18. Yasufumi Nishikawa, Yukari Kajiura, Hwan Jung Lew, Jun-ichi Kido, Toshihiko Nagata and Koji Naruishi :
Calprotectin Induces IL-6 and MCP-1 Production via Toll-Like Receptor 4 Signaling in Human Gingival Fibroblasts.,
Journal of Cellular Physiology, Vol.232, No.7, 1862-1871, 2017.
(DOI: 10.1002/jcp.25724,   PubMed: 27925202,   Elsevier: Scopus)
19. Koji Naruishi, Keiji Oishi, Yuuji Inagaki, Masumi Horibe, Mika Bandou, Masami Ninomiya, K Kawahara, J Minakuchi, S Kawashima, K Shima, Jun-ichi Kido and Toshihiko Nagata :
Association between Periodontal Condition and Kidney Dysfunction in Japanese Adults: A Cross-Sectional Study,
Clinical and Experimental Dental Research, Vol.2, No.2, 1-8, 2016.
(DOI: 10.1002/cre2.39)
20. K Takeuchi-Hatanaka, T Yasuda, Koji Naruishi, K Katsuragi-Fuke, J Inubushi, H Ootsuki, H Maeda and S Takashiba :
Effects of new over-the-counter periodontal ointment-containing applicator with single-tuft brush on cytokine levels in gingival crevicular fluid during supportive periodontal therapy phase: a randomized double-blind clinical trial.,
Journal of Periodontal Research, Vol.51, No.3, 321-331, 2016.
(DOI: 10.1111/jre.12311,   PubMed: 26251312,   Elsevier: Scopus)
21. Koji Naruishi, Yukari Kajiura, 西川 泰史, Mika Bandou, Jun-ichi Kido and Toshihiko Nagata :
Inhibitory Effects of Cryptotanshinone on Inflammation-related Molecules in Human Gingival Fibroblasts,
The Japanese Journal of Conservative Dentistry, Vol.58, No.3, 212-218, 2015.
(DOI: 10.11471/shikahozon.58.212,   CiNii: 130005086794)
22. Jun-ichi Kido, Yukiko Bandou, Mika Bandou, Yukari Kajiura, Yuka Hiroshima, Yuji Inagaki, Hiromi Murata, Takahisa Ikuta, Reiko Kido, Koji Naruishi, Makoto Funaki and Toshihiko Nagata :
YKL-40 level in gingival crevicular fluid from patients with periodontitis and type 2 diabetes,
Oral Diseases, Vol.21, No.5, 667-673, 2015.
(DOI: 10.1111/odi.12334,   PubMed: 25740558,   Elsevier: Scopus)
23. Yuji Inagaki, Yukiko Nakajima, Masumi Horibe, 生田 貴久, Yukari Kajiura, Koji Naruishi, Jun-ichi Kido and Toshihiko Nagata :
肥満糖尿病ラット歯周炎の歯肉組織におけるオステオポンチンの局在,
Journal of the Japanese Association of Periodontology, Vol.67, No.4, 149-158, 2015.
24. Koji Naruishi, Akiko Kunita, Katsuyuki Kubo, Toshihiko Nagata, Shogo Takashiba and Seiji Adachi :
Predictors of improved functional outcome in elderly inpatients after rehabilitation: a retrospective study.,
Clinical Interventions in Aging, Vol.9, 2133-2141, 2014.
(DOI: 10.2147/CIA.S73388,   PubMed: 25584025)
25. Kazuhiro Omori, Yoshihisa Hanayama, Koji Naruishi, Kentaro Akiyama, Hiroshi Maeda, Fumio Otsuka and Shogo Takashiba :
Gingival overgrowth caused by vitamin C deficiency associated with metabolic syndrome and severe periodontal infection: a case report.,
Clinical Case Reports, Vol.2, No.6, 286-295, 2014.
(DOI: 10.1002/ccr3.114,   PubMed: 25548632)
26. 久保 克行, 目黒 道夫, 竹内 いずみ, 中山 良子, 加藤 真由美, Koji Naruishi, 澤田 弘一, 足立 誠司 and 山下 裕 :
ADL,認知機能の低下及び低栄養を併発した老年症候群患者は摂食嚥下機能が低下する,
全国自治体病院協議会雑誌, Vol.53, No.6, 943-948, 2014.
27. Tetsuo Fujita, Takefumi Satoh, L Terry Timme, Takahiro Hirayama, X Julie Zhu, Nobuyuki Kusaka, Koji Naruishi, Guang Yang, Alexei Goltsov, Jianxiang Wang, T Maria Vlachaki, S Bin Teh, E Butler Brian and C Timothy Thompson :
Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models.,
Urologic Oncology: Seminars and Original Investigations, Vol.32, No.2, 92-100, 2014.
(DOI: 10.1016/j.urolonc.2012.10.007,   PubMed: 23433894)
28. Naoki Takizawa, Shunsuke Sawada, Naoyuki Chosa, Akira Ishisaki and Koji Naruishi :
Secreted caveolin-1 enhances periodontal inflammation by targeting gingival fibroblasts.,
Biomedical Research, Vol.34, No.1, 1-11, 2013.
(DOI: 10.2220/biomedres.34.1,   PubMed: 23428975,   Elsevier: Scopus)
29. Shunsuke Sawada, Naoyuki Chosa, Akira Ishisaki and Koji Naruishi :
Enhancement of gingival inflammation induced by synergism of IL-1 and IL-6.,
Biomedical Research, Vol.34, No.1, 31-40, 2013.
(DOI: 10.2220/biomedres.34.31,   PubMed: 23428978,   Elsevier: Scopus)
30. C Kudo, Koji Naruishi, H Maeda, Y Abiko, T Hino, M Iwata, C Mitsuhashi, S Murakami, T Nagasawa, Toshihiko Nagata, Satoshi Yoneda, Y Nomura, T Noguchi, Y Numabe, Y Ogata, T Sato, H Shimauchi, K Yamazaki, A Yoshimura and S Takashiba :
Assessment of the plasma/serum IgG test to screen for periodontitis.,
Journal of Dental Research, Vol.91, No.12, 1190-1195, 2012.
(DOI: 10.1177/0022034512461796,   PubMed: 23018816)
31. Tamaki Takahashi, Shigeo Muro, Naoya Tanabe, Kunihiko Terada, Hirofumi Kiyokawa, Susumu Sato, Yuma Hoshino, Emiko Ogawa, Kazuko Uno, Koji Naruishi, Shogo Takashiba and Michiaki Mishima :
Relationship between periodontitis-related antibody and frequent exacerbations in chronic obstructive pulmonary disease.,
PLoS ONE, Vol.7, No.7, e40570, 2012.
(DOI: 10.1371/journal.pone.0040570,   PubMed: 22792372)
32. Shinya Tsuge, Yasuyoshi Mizutani, Kazuhiro Matsuoka, Tatsuya Sawasaki, Yaeta Endo, Koji Naruishi, Hiroshi Maeda, Shogo Takashiba, Kazuya Shiogama, Ken-Ichi Inada and Yutaka Tsutsumi :
Specific in situ visualization of plasma cells producing antibodies against Porphyromonas gingivalis in gingival radicular cyst: application of the enzyme-labeled antigen method.,
The Journal of Histochemistry and Cytochemistry, Vol.59, No.7, 673-689, 2011.
(DOI: 10.1369/0022155411408906,   PubMed: 21525188)
33. Koji Naruishi, K Omori, H Maeda, N Sonoi, K Funakoshi, K Hirai, M Ishii, K Kubo, H Kobayashi, T Tomiyama, D Yamamoto, I Tanimoto, K Kunimatsu and S Takashiba :
Immune responses to porphyromonas gingivalis infection suppress systemic inflammatory response in experimental murine model.,
Journal of Biological Regulators and Homeostatic Agents, Vol.25, No.2, 195-202, 2011.
(PubMed: 21880208,   Elsevier: Scopus)
34. 村井 治, Koji Naruishi, 佐々木 大輔, 大川 義人, 八重柏 隆 and 國松 和司 :
臨床研究 医科歯科連携医療における歯周病原細菌に対する血清IgG抗体価検査の導入,
Journal of Japanese Society for Evidence and the Dental Professional, Vol.3, No.1, 36-41, 2011.
(CiNii: 40018833866)
35. Noriko Sugi, Koji Naruishi, Chieko Kudo, Aya Hisaeda-Kako, Takayuki Kono, Hiroshi Maeda and Shogo Takashiba :
Prognosis of periodontitis recurrence after intensive periodontal treatment using examination of serum IgG antibody titer against periodontal bacteria.,
Journal of Clinical Laboratory Analysis, Vol.25, No.1, 25-32, 2011.
(DOI: 10.1002/jcla.20381,   PubMed: 21254239)
36. Osamu Murai, Koji Naruishi, Satoshi Ogihara, Nagisa Suwa, Satomi Kanazawa, Takashi Yaegashi, Yasunori Takeda and Kazushi Kunimatsu :
Cathepsin B, D, and L regulation in cyclosporin A-mediated gingival hyperplasia of a patient with sarcoidosis.,
Clinical Laboratory, Vol.57, No.7-8, 535-541, 2011.
(PubMed: 21888018)
37. Junya INUBUSHI, Kazu HATANAKA, Takako YASUDA, Koji Naruishi, Hidehiko OOTSUKI and Shogo TAKASHIBA :
Clinical and microbiological effect of newly developed OTC periodontal ointment-containing applicator with brush on the SPT phase,
Journal of the Japanese Association of Periodontology, Vol.52, No.3, 225-238, 2010.
(DOI: 10.2329/perio.52.225,   CiNii: 10027096396)
38. K Yamabe, H Maeda, S Kokeguchi, Y Soga, M Meguro, Koji Naruishi, S Asakawa and S Takashiba :
Antigenic group II chaperonin in Methanobrevibacter oralis may cross-react with human chaperonin CCT.,
Molecular Oral Microbiology, Vol.25, No.2, 112-122, 2010.
(DOI: 10.1111/j.2041-1014.2009.00548.x,   PubMed: 20331799,   Elsevier: Scopus)
39. Y Koide, H Maeda, K Yamabe, Koji Naruishi, T Yamamoto, S Kokeguchi and S Takashiba :
Rapid detection of mecA and spa by the loop-mediated isothermal amplification (LAMP) method.,
Letters in Applied Microbiology, Vol.50, No.4, 386-392, 2010.
(DOI: 10.1111/j.1472-765X.2010.02806.x,   PubMed: 20149082)
40. 小出 康史, 杉 典子, 向井 麻理子, 児玉 由佳, 竹本 奈奈, 大隅 満奈, 藤井 友利江, Koji Naruishi and 高柴 正悟 :
臨床研究 周術期患者に対する口腔管理システムの樹立と評価,
Journal of Japanese Society for Evidence and the Dental Professional, Vol.2, No.1, 45-49, 2010.
(CiNii: 120002519738)
41. Takemasa Maeda, Hiroshi Maeda, Kokoro Yamabe, Junji Mineshiba, Ichiro Tanimoto, Tadashi Yamamoto, Koji Naruishi, Susumu Kokeguchi and Shogo Takashiba :
Highly expressed genes in a rough-colony-forming phenotype of Aggregatibacter actinomycetemcomitans: implication of a mip-like gene for the invasion of host tissue.,
FEMS Immunology and Medical Microbiology, Vol.58, No.2, 226-236, 2009.
(DOI: 10.1111/j.1574-695X.2009.00624.x,   PubMed: 19903198)
42. Masami Watanabe, Guang Yang, Guangwen Cao, A Salahaldin Tahir, Koji Naruishi, Ken-Ichi Tabata, Abdel Elmoataz Fattah, Kartik Rajagopalan, L Terry Timme, Sanghee Park, Shinji Kurosaka, Kohei Edamura, Ryuta Tanimoto, J Francesco Demayo, A Alexei Goltsov and C Timothy Thompson :
Functional analysis of secreted caveolin-1 in mouse models of prostate cancer progression.,
Molecular Cancer Research : MCR, Vol.7, No.9, 1446-1455, 2009.
(DOI: 10.1158/1541-7786.MCR-09-0071,   PubMed: 19737975)
43. Y-S Ho, M-T Lai, S-J Liu, C-T Lin, Koji Naruishi, S Takashiba and H-H Chou :
Porphyromonas gingivalis fimbriae-dependent interleukin-6 autocrine regulation by increase of gp130 in endothelial cells.,
Journal of Periodontal Research, Vol.44, No.4, 550-556, 2009.
(DOI: 10.1111/j.1600-0765.2008.01150.x,   PubMed: 19438975)
44. 工藤 値英子, Koji Naruishi, 久松 綾, 新井 英雄, 前田 博史 and 高柴 正悟 :
歯周病スクリーニング検査としての歯周病原細菌に対する指尖血漿IgG抗体価の有用性,
Journal of Japanese Society for Evidence and the Dental Professional, Vol.1, No.1, 13-19, 2009.
(CiNii: 120002443344)
45. K Tabata, M Watanabe, Koji Naruishi, K Edamura, T Satoh, G Yang, E Fattah Abdel, J Wang, A Goltsov, D Floryk, D S Soni, D Kadmon and C T Thompson :
Therapeutic effects of gelatin matrix-embedded IL-12 gene-modified macrophages in a mouse model of residual prostate cancer.,
Prostate Cancer and Prostatic Diseases, Vol.12, No.3, 301-309, 2008.
(DOI: 10.1038/pcan.2008.57,   PubMed: 19104507)
46. Tomoko Yamaguchi, Koji Naruishi, Hideo Arai, Fusanori Nishimura and Shogo Takashiba :
IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts.,
Journal of Cellular Physiology, Vol.217, No.2, 423-432, 2008.
(DOI: 10.1002/jcp.21517,   PubMed: 18543249)
47. 福家 教子, 苅田 典子, 熊崎 洋平, Koji Naruishi, 大西 典子, 明貝 文夫, 岩本 義博, 新井 英雄 and 高柴 正悟 :
サポーティブペリオドンタルセラピーによる歯周炎の再発防止と進行抑制の効果に関する統計学的検討,
The Journal of Okayama Dental Society, Vol.27, No.2, 105-113, 2008.
48. Guang Yang, L Terry Timme, Koji Naruishi, Tetsuo Fujita, Abdel El Moataz Fattah, Guangwen Cao, Kartik Rajagopalan, Kartik Rajocopolan, D Luan Troung and C Timothy Thompson :
Mice with cav-1 gene disruption have benign stromal lesions and compromised epithelial differentiation.,
Experimental and Molecular Pathology, Vol.84, No.2, 131-140, 2007.
(DOI: 10.1016/j.yexmp.2007.08.004,   PubMed: 18358473)
49. Kazuhiro Omori, Koji Naruishi, Tomoko Yamaguchi, Shun-Ai Li, Mayumi Yamaguchi-Morimoto, Kaori Matsuura, Hideo Arai, Kohji Takei and Shogo Takashiba :
cAMP-response element binding protein (CREB) regulates cyclosporine-A-mediated down-regulation of cathepsin B and L synthesis.,
Cell and Tissue Research, Vol.330, No.1, 75-82, 2007.
(DOI: 10.1007/s00441-007-0457-8,   PubMed: 17724614)
50. H Wang, G Yang, L T Timme, T Fujita, Koji Naruishi, A Frolov, K M Brenner, D Kadmon and C T Thompson :
IL-12 gene-modified bone marrow cell therapy suppresses the development of experimental metastatic prostate cancer.,
Cancer Gene Therapy, Vol.14, No.10, 819-827, 2007.
(DOI: 10.1038/sj.cgt.7701069,   PubMed: 17627292)
51. Arias Zulema Rosalia Martinez, Koji Naruishi, Keisuke Yamashiro, Fumio Myokai, Teruo Yamada, Kaori Matsuura, Naoko Namba, Hideo Arai, Junzo Sasaki, Yoshimitsu Abiko and Shogo Takashiba :
Gene profiles during root canal treatment in experimental rat periapical lesions.,
Journal of Endodontics, Vol.33, No.8, 936-943, 2007.
(DOI: 10.1016/j.joen.2007.04.016,   PubMed: 17878078)
52. T Fujita, L T Timme, K Tabata, Koji Naruishi, N Kusaka, M Watanabe, E Abdelfattah, X J Zhu, C Ren, C Ren, G Yang, A Goltsov, H Wang, T M Vlachaki, S B Teh, B E Butler and C T Thompson :
Cooperative effects of adenoviral vector-mediated interleukin 12 gene therapy with radiotherapy in a preclinical model of metastatic prostate cancer.,
Gene Therapy, Vol.14, No.3, 227-236, 2006.
(DOI: 10.1038/sj.gt.3302788,   PubMed: 17024109)
53. Nobuyuki Shiomi, Fumio Myokai, Koji Naruishi, Kosuke Oyaizu, Kyoko Senoo, Tomoko Yamaguchi, Salomon Amar and Shogo Takashiba :
Cloning and characterization of lipopolysaccharide-induced tumor necrosis factor alpha factor promoter.,
FEMS Immunology and Medical Microbiology, Vol.47, No.3, 360-368, 2006.
(DOI: 10.1111/j.1574-695X.2006.00094.x,   PubMed: 16872372)
54. Koji Naruishi, L T Timme, N Kusaka, T Fujita, G Yang, A Goltsov, T Satoh, X Ji, W Tian, E Abdelfattah, T Men, M Watanabe, K Tabata and C T Thompson :
Adenoviral vector-mediated RTVP-1 gene-modified tumor cell-based vaccine suppresses the development of experimental prostate cancer.,
Cancer Gene Therapy, Vol.13, No.7, 658-663, 2006.
(DOI: 10.1038/sj.cgt.7700919,   PubMed: 16485011)
55. Tetsuo Fujita, S Bin Teh, L Terry Timme, Wei-Yuan Mai, Takefumi Satoh, Nobuyuki Kusaka, Koji Naruishi, Abdel Elmoataz Fattah, Estuardo Aguilar-Cordova, Brian E Butler and C Timothy Thompson :
Sustained long-term immune responses after in situ gene therapy combined with radiotherapy and hormonal therapy in prostate cancer patients.,
International Journal of Radiation Oncology*Biology*Physics, Vol.65, No.1, 84-90, 2006.
(DOI: 10.1016/j.ijrobp.2005.11.009,   PubMed: 16472937)
56. Mayumi Yamaguchi, Koji Naruishi, Hisa Yamada-Naruishi, Kazuhiro Omori, Fusanori Nishimura and Shogo Takashiba :
Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts.,
Journal of Periodontal Research, Vol.39, No.5, 320-326, 2004.
(DOI: 10.1111/j.1600-0765.2004.00746.x,   PubMed: 15324353)
57. Milan Petelin, Koji Naruishi, Nobuyuki Shiomi, Junji Mineshiba, Hideo Arai, Fusanori Nishimura, Shogo Takashiba and Yoji Murayama :
Systemic up-regulation of sTNFR2 and IL-6 in Porphyromonas gingivalis pneumonia in mice.,
Experimental and Molecular Pathology, Vol.76, No.1, 76-81, 2004.
(PubMed: 14738872)
58. Kazuhiro Omori, Koji Naruishi, Fusanori Nishimura, Hisa Yamada-Naruishi and Shogo Takashiba :
High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblasts.,
The Journal of Biological Chemistry, Vol.279, No.8, 6643-6649, 2003.
(DOI: 10.1074/jbc.M311688200,   PubMed: 14676217)
59. Koji Naruishi, Fusanori Nishimura, Hisa Yamada-Naruishi, Kazuhiro Omori, Mayumi Yamaguchi and Shogo Takashiba :
C-jun N-terminal kinase (JNK) inhibitor, SP600125, blocks interleukin (IL)-6-induced vascular endothelial growth factor (VEGF) production: cyclosporine A partially mimics this inhibitory effect.,
Transplantation, Vol.76, No.9, 1380-1382, 2003.
(DOI: 10.1097/01.TP.0000085661.52980.95,   PubMed: 14627919)
60. Fusanori Nishimura, Hisa Naruishi, Koji Naruishi, Teruo Yamada, Junzo Sasaki, Christoph Peters, Yasuo Uchiyama and Yoji Murayama :
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.,
The American Journal of Pathology, Vol.161, No.6, 2047-2052, 2002.
(DOI: 10.1016/S0002-9440(10)64483-5,   PubMed: 12466121)
61. Koji Naruishi, S Takashiba, F Nishimura, H H Chou, H Arai, H Yamada and Y Murayama :
Impairment of gingival fibroblast adherence by IL-6/sIL-6R.,
Journal of Dental Research, Vol.80, No.5, 1421-1424, 2001.
(PubMed: 11437212)
62. H Yamada, F Nishimura, K Furuno, Koji Naruishi, Y Kobayashi, S Takashiba and Y Murayama :
Serum phenytoin concentration and IgG antibody titre to periodontal bacteria in patients with phenytoin-induced gingival overgrowth.,
Journal of the International Academy of Periodontology, Vol.3, No.2, 42-47, 2001.
(PubMed: 12666977)
63. H Ohe, S Takashiba, Koji Naruishi, H H Chou, H Yamada, F Nishimura, H Arai and Y Murayama :
Tumor necrosis factor-alpha (TNF-alpha)-induced and interleukin-1 beta (IL-1 beta)-induced shedding of TNF receptors from gingival fibroblasts.,
Journal of Interferon and Cytokine Research, Vol.20, No.12, 1077-1082, 2000.
(DOI: 10.1089/107999000750053744,   PubMed: 11152574)
64. H H Chou, S Takashiba, H Maeda, Koji Naruishi, F Nishimura, H Arai, H Lu and Y Murayama :
Induction of intracellular interleukin-1 beta signals via type II interleukin-1 receptor in human gingival fibroblasts.,
Journal of Dental Research, Vol.79, No.9, 1683-1688, 2000.
(PubMed: 11023264)
65. F Nishimura, Koji Naruishi, H Yamada, T Kono, S Takashiba and Y Murayama :
High glucose suppresses cathepsin activity in periodontal-ligament-derived fibroblastic cells.,
Journal of Dental Research, Vol.79, No.8, 1614-1617, 2000.
(PubMed: 11023284)
66. Yoji Asahara, Fusanori Nishimura, Hisa Yamada, Koji Naruishi, Masatoshi Kataoka, Jun-ichi Kido, Toshihiko Nagata and Yoji Murayama :
Mast cells are not involved in the development of cyclosporin A-induced gingival hyperplasia: a study with mast cell-deficient mice,
Journal of Periodontology, Vol.71, No.7, 1117-1120, 2000.
(DOI: 10.1902/jop.2000.71.7.1117,   PubMed: 10960018)
67. H Yamada, F Nishimura, Koji Naruishi, H H Chou, S Takashiba, M G Albright, S Nares, M A Iacopino and Y Murayama :
Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts.,
Journal of Periodontology, Vol.71, No.6, 955-960, 2000.
(DOI: 10.1902/jop.2000.71.6.955,   PubMed: 10914799)
68. Koji Naruishi, S Takashiba, H H Chou, H Arai, F Nishimura and Y Murayama :
Role of soluble interleukin-6 receptor in inflamed gingiva for binding of interleukin-6 to gingival fibroblasts.,
Journal of Periodontal Research, Vol.34, No.6, 296-300, 1999.
(PubMed: 10633884)
69. Koji Naruishi :
線維芽細胞におけるIL-6の刺激伝達,
The Journal of Okayama Dental Society, Vol.17, No.4, 33-43, 1998.
(CiNii: 80010371785)

Academic Paper (Unrefereed Paper):

1. Jun-ichi Kido, Mika Bandou, Yuji Inagaki, 生田 貴久, Yukari Kajiura, Yukiko Nakajima, Eijiro Sakamoto, Chie Mihara-Wada, Masami Ninomiya, 西川 泰史, Jung-Hwan Lew, Koji Naruishi and Toshihiko Nagata :
Diagnosis of Periodontal Diseases using Biomarkers in Gingival Crevicular Fluid,
Journal of Oral Health and Biosciences, Vol.29, No.1, 13-20, 2016.
(Tokushima University Institutional Repository: 109875,   CiNii: 120005823530)
2. 内藤 仁美, 工藤 値英子, 目黒 道生, Koji Naruishi, 伊東 孝, 前田 博史 and 高柴 正悟 :
ある侵襲性歯周炎患者の26年間における歯周病治療の経過 -血清IgG抗体価による歯周病原細菌感染度もモニタリング-,
日本歯周病学会誌, Vol.56, No.2, 217-226, 2014.
3. Osamu Murai, Daisuke Sasaki, Yoshinori Ando, Akira Fujimura, Hiromi Oikawa, Nagisa Suwa, Daisuke Watabe, Fumihiko Maeda, Kohki Endo, Takashi Yaegashi, Toshihide Akasaka and Koji Naruishi :
Improvement of pustulosis palmaris et plantaris by periodontal infection control in a patient with chronic periodontitis.,
Clinical Laboratory, Vol.58, No.3-4, 323-327, 2012.
(PubMed: 22582507,   Elsevier: Scopus)
4. Koji Naruishi, Shunsuke SAWADA, Osamu MURAI, Yasunori TAKEDA, Takashi KAWAMURA, Kae WAKABAYASHI, Yukinori KUWASHIMA, Hiroyuki MIURA and Kazushi KUNIMATSU :
A Case of Root of Apexification in Extruded-Immature Permanent Incisor,
Dental journal of Iwate Medical University, Vol.36, No.1, 53-58, 2011.
(CiNii: 110008752160)
5. Koji Naruishi and Kazushi KUNIMATSU :
A Case Report of Severe Chronic Periodontitis Evaluated by Serum IgG Antibody Titer Test against Periodontal Pathogens,
Dental journal of Iwate Medical University, Vol.35, No.3, 146-152, 2010.
(CiNii: 110008440539)
6. Chieko KUDO, Takayuki KONO, Hidenori Nishimura, Hideki OHYAMA, Fumio MYOKAI, Koji Naruishi, Yoshihiro IWAMOTO, Naoki TAKAHASHI, Yoshihiko SOGA, Hideo ARAI, Yoji MURAYAMA and Shogo TAKASHIBA :
A Case Report of Rheumatoid Arthritis Patient with Severe Periodontitis Whose Inflammatory Marker Improved by Periodontal Treatment,
The Japanese Journal of Conservative Dentistry, Vol.46, No.1, 110-117, 2003.
(CiNii: 80015840375)

Academic Letter:

1. Koji Naruishi, Akiko Kunita, Toshihiko Nagata, Shogo Takashiba and Seiji Adachi :
Cut-off values of Functional Independence Measure scores for discharge destination.,
Geriatrics & Gerontology International, Vol.15, No.5, 670-671, 2015.
(DOI: 10.1111/ggi.12430,   PubMed: 25899761,   Elsevier: Scopus)

Review, Commentary:

1. Koji Naruishi and Hiromichi Yumoto :
糖尿病と慢性腎疾患(CKD),
月刊糖尿病, Vol.11, No.4, 80-85, Oct. 2019.
2. Koji Naruishi and Toshihiko Nagata :
Biological effects of interleukin-6 on Gingival Fibroblasts: Cytokine regulation in periodontitis.,
Journal of Cellular Physiology, Vol.233, No.9, 6393-6400, Mar. 2018.
(DOI: 10.1002/jcp.26521,   PubMed: 29574949)
3. Koji Naruishi and Yasufumi Nishikawa :
Crosstalk of Gingival Fibroblasts and Macrophages in Inflammatory Cytokine Cascade: Potential Mechanisms of Periodontitis,
Journal of Cell Signaling, Vol.2, No.2, e149, Jun. 2017.
(DOI: 10.4172/2576-1471.1000149)
4. Koji Naruishi and Toshihiko Nagata :
最新の知見から攻める!①歯周病と腎疾患はどう関係するの?,
The Journal of Dental Hygiene, Vol.36, No.3, 304-305, Mar. 2016.
5. Koji Naruishi and Toshihiko Nagata :
歯周病が生活習慣病に及ぼす影響,
The Japanese Journal of Clinical Nutrition, Vol.126, No.3, 262-267, Mar. 2015.
6. Kazuhiro Omori, Chieko Kudo, Koji Naruishi, Hiroshi Maeda and Shogo Takashiba :
Basic Research to Clinical Dentistry:Potentiality of plasma IgG antibody titer test against to periodontal pathogens,
Journal of the Japanese Association of Periodontology, Vol.55, No.1, 9-14, 2013.
(DOI: 10.2329/perio.55.9,   CiNii: 130003393031)
7. C T Thompson, A S Tahir, L Li, M Watanabe, Koji Naruishi, G Yang, D Kadmon, J C Logothetis, P Troncoso, C Ren, A Goltsov and S Park :
The role of caveolin-1 in prostate cancer: clinical implications.,
Prostate Cancer and Prostatic Diseases, Vol.13, No.1, 6-11, Jul. 2009.
(DOI: 10.1038/pcan.2009.29,   PubMed: 19581923)
8. Koji Naruishi :
Gingival Fibroblasts-mediated Pathophysiology of Periodontal Diseases, Periodontitis and Drug-induced Gingival Overgrowth,
Journal of the Japanese Association of Periodontology, Vol.51, No.1, 7-18, Mar. 2009.
(DOI: 10.2329/perio.51.007,   CiNii: 10027095287)
9. Shogo Takashiba and Koji Naruishi :
Gene polymorphisms in periodontal health and disease.,
Periodontology 2000, Vol.40, 94-106, 2006.
(DOI: 10.1111/j.1600-0757.2005.00142.x,   PubMed: 16398687)
10. Shogo Takashiba, Koji Naruishi and Yoji Murayama :
Perspective of cytokine regulation for periodontal treatment: fibroblast biology.,
Journal of Periodontology, Vol.74, No.1, 103-110, Jan. 2003.
(DOI: 10.1902/jop.2003.74.1.103,   PubMed: 12593604)

Proceeding of International Conference:

1. Yasufumi Nishikawa, Koji Naruishi, Jun-ichi Kido and Hiromichi Yumoto :
Diabetic high-glucose condition enhances calprotectin-induced inflammatory responses in gingival fibroblasts,
97th General Session & Exhibition of the International Association for Dental Research (Vancouver, Canada), Jun. 2019.
2. Yuji Inagaki, Kohei Nonaka, Ryosuke Takagi, Yasufumi Nishikawa, Rie Kido, Eijiro Sakamoto, Koji Naruishi, Jun-ichi Kido and Hiromichi Yumoto :
Kanroin Extracts Prevent Alveolar Bone Resorption in Experimental Rat Periodontitis,
96th General Session & Exhibition of the International Association of Dental Research, Jul. 2018.
3. Yuka Hiroshima, Eijiro Sakamoto, Kaori Abe, Kaya Yoshida, Koji Naruishi, Toshihiko Nagata, Yasuo Shinohara, Geczy Carolyn and Jun-ichi Kido :
Advanced Glycation End-Products Increase Calprotectin in Human Gingival Epithelial Cells,
The 95th General Session & Exhibition of the International Association for Dental Research (IADR), San Francisco, Mar. 2017.
4. Eijiro Sakamoto, Yuji Inagaki, Jun-ichi Kido, Takagi Ryosuke, Koji Naruishi and Toshihiko Nagata :
AGE and Porphyromonas gingival is-LPS Increase Sclerostin Expression in Osteocytes,
International Association for Dental Research, Mar. 2017.
5. Jung-Hwan Lew, Koji Naruishi, Yukari Kajiura, Yasufumi Nishikawa, Jun-ichi Kido and Toshihiko Nagata :
High glucose enhances IL-6-induced protease production in gingival fibroblasts,
94th General Session & Exhibition, International Association for Dental Research, Seoul, Jun. 2016.
6. Yasufumi Nishikawa, Koji Naruishi, Yukari Kajiura, Jung-Hwan Lew, Jun-ichi Kido and Toshihiko Nagata :
Calprotectin induced the expression of inflammation-related molecules in gingival fibroblasts,
94th General Session & Exhibition, International Association for Dental Research, Seoul, Jun. 2016.
7. Yukari Kajiura, Koji Naruishi, Yukiko Nakajima, Yasufumi Nishikawa, Jung-Hwan Lew, Jun-ichi Kido and Toshihiko Nagata :
High glucose enhaces P. gingivalis-induced cytokine production in THP-1 monocytes,
94th General Session & Exhibition, International Association for Dental Research, Seoul, Jun. 2016.
8. Syotaro Yoshioka, Yoshiteru Tada, Junichiro Satomi, Kenji Yagi, Koji Naruishi, Kazuyuki Kuwayama, Keiko Kitazato, Takeshi Miyamoto, Yasuhisa Kanematsu, Masafumi Harada, Toshihiko Nagata and Shinji Nagahiro :
Impact of Periodontal Disease and Bacteria on Intracranial Aneurysms,
International Stroke Conference 2016, Los Angeles, Feb. 2016.
9. Masami Ninomiya, Keiji Oishi, Hashimoto Mari, Koji Naruishi, Yamanouchi Kouji, Fukumura Yoshiaki and Toshihiko Nagata :
A Cross-Sectional Study on the Severity of Periodontitis in Infective Endocarditis Patients,
11th Asian Pacific Society of Periodontology Meeting, Oct. 2015.
10. T Ikuta, Yukari Kajiura, Mika Bandou, Yuji Inagaki, Koji Naruishi, Jun-ichi Kido and Toshihiko Nagata :
YKL-40 in gingival crevicular fluid from patients with periodontitis and diabetes.,
Euro Perio 2015, Jun. 2015.
11. Koji Naruishi and Toshihiko Nagata :
HGFs-macrophage crosstalk: sIL-6R secretion in THP-1 macrophages,
62th Annual Meeting of Japanese Association for Dental Reserch Abstract, Dec. 2014.

Proceeding of Domestic Conference:

1. Masami Ninomiya, Takahisa Ikuta, Koji Naruishi and Hiromichi Yumoto :
重度慢性歯周炎を有する血液透析患者に対して包括的歯周治療を行った一症例,
日本歯科保存学会 2019年度秋季学術大会(第151回), Nov. 2019.
2. Kohei Nonaka, Mika Bandou, Jun-ichi Kido, Yuji Inagaki, Eijiro Sakamoto, Koji Naruishi and Hiromichi Yumoto :
ショウガオールはヒト歯肉線維芽細胞においてAGEs誘導性の酸化ストレスを抑制する,
第62回秋季日本歯周病学会学術大会 (北九州), Oct. 2019.
3. Yuka Hiroshima, Jun-ichi Kido, 木戸 理恵, Kaya Yoshida, Yuji Inagaki, Koji Naruishi and Hiromichi Yumoto :
オーラルケアへの応用を目指した抗菌ペプチド合成とリポソーム封入,
第62回秋季日本歯周病学会学術大会, Oct. 2019.
4. Ryosuke Takagi, Eijiro Sakamoto, Yuji Inagaki, Koji Naruishi, Jun-ichi Kido and Hiromichi Yumoto :
S100A9はMAPKおよびSTAT3経路を介して骨細胞におけるIL-6とRANKLの発現を調節する,
日本歯科保存学会 2019年度春季学術大会(第150回) (金沢), Jun. 2019.
5. Masami Ninomiya, Eijiro Sakamoto, Koji Naruishi, Takahisa Ikuta, Ryosuke Takagi, Hatanaka Kazu, Okamoto Kentaro, Ono Shintaro, Takashiba Shogo and Hiromichi Yumoto :
A Familial Case of Severe Periodontitis associated with Cyclic Neutropenia,
Journal of the Japanese Association of Periodontology, Vol.61, 164, May 2019.
6. Rie Kido, Yuka Hiroshima, Takahisa Ikuta, Kaya Yoshida, Yuji Inagaki, Koji Naruishi, Kazumi Ozaki, Jun-ichi Kido and Hiromichi Yumoto :
最終糖化産物はヒト口腔上皮細胞のリポカリン2発現を増加する,
第62回春季日本歯周病学会学術大会, May 2019.
7. Yuji Inagaki, 高木 亮輔, Yasufumi Nishikawa, 木戸 理恵, Eijiro Sakamoto, Koji Naruishi, Jun-ichi Kido and Hiromichi Yumoto :
甘露飲エキスは破骨細胞と骨芽細胞の分化制御を介してラット実験的歯周炎の歯槽骨吸収を抑制する,
日本歯科保存学会2018年度秋季学術大会(第149回), Nov. 2018.
8. Masami Ninomiya, Ikuta Takahisa, Koji Naruishi and Hiromichi Yumoto :
A case report of comprehensive periodontal treatment for a patient with infective endocarditis caused by oral bacteria,
日本歯科保存学会2018年度秋季学術大会(第149回), 163, Nov. 2018.
9. Nonaka Kohei, Mika Bandou, Jun-ichi Kido, Yuji Inagaki, Eijiro Sakamoto, Koji Naruishi and Hiromichi Yumoto :
ショーガオールはヒト歯肉線維芽細胞におけるAGEs誘導性のIL-6およびICAM-1産生を抑制する,
第62回秋季日本歯周病学会学術大会, Oct. 2018.
10. Junichiro Satomi, Shotaroh Yoshioka, Takeshi Miyamoto, Koji Naruishi, 北里 慶子, Yoshiteru Tada, Masafumi Harada, Yasushi Takagi and Shinji Nagahiro :
脳動脈瘤と歯周病との関連,
日本脳神経外科学会第77回学術総会, Oct. 2018.
11. Yasufumi Nishikawa, Koji Naruishi, Jun-ichi Kido and Hiromichi Yumoto :
歯肉線維芽細胞におけるカルプロテクチン誘導性炎症関連因子の産生に及ぼす高グルコースの影響,
第148回日本歯科保存学会秋季学術大会, Jun. 2018.
12. Yuji Inagaki, Nonaka Kohei, Takagi Ryosuke, Yasufumi Nishikawa, Kido Rie, Eijiro Sakamoto, Koji Naruishi, Jun-ichi Kido and Hiromichi Yumoto :
甘露飲エキス配合製剤はラット実験的歯周炎において歯槽骨吸収を抑制する,
第61回春季日本歯周病学会学術大会, Jun. 2018.
13. Kido Rie, Eijiro Sakamoto, Mika Bandou, Yuji Inagaki, Masami Ninomiya, Chie Mihara-Wada, Takahisa Ikuta, Koji Naruishi, Toshihiko Nagata, Jun-ichi Kido and Hiromichi Yumoto :
インプラント周囲溝滲出液中のカルプロテクチンとNTxを用いたインプラント疾患の診断,
第61回春季日本歯周病学会学術大会, Jun. 2018.
14. 高木 亮輔, Eijiro Sakamoto, Yuji Inagaki, Yuka Hiroshima, Koji Naruishi, Jun-ichi Kido and Hiromichi Yumoto :
カルプロテクチンはマウス骨細胞の炎症および骨代謝関連因子の発現を制御する,
第61回春季日本歯周病学会学術大会, Jun. 2018.
15. 野中 康平, Mika Bandou, Jun-ichi Kido, Yuji Inagaki, Eijiro Sakamoto, Koji Naruishi and Hiromichi Yumoto :
最終糖化産物はヒト歯肉線維芽細胞におけるIL-6とICAM-1の発現増加を介して単球との接着を誘導する,
第61回春季日本歯周病学会学術大会, Jun. 2018.
16. 木戸 理恵, Eijiro Sakamoto, Mika Bandou, Yuji Inagaki, Masami Ninomiya, Chie Mihara-Wada, Takahisa Ikuta, Koji Naruishi, Toshihiko Nagata, Jun-ichi Kido and Hiromichi Yumoto :
インプラント周囲溝滲出液中のカルプロテクチンとNTxを用いたインプラント疾患の診断,
第61回春季日本歯周病学会学術大会, Jun. 2018.
17. Ryosuke Takagi, Eijiro Sakamoto, Yuji Inagaki, Yuka Hiroshima, Koji Naruishi, Jun-ichi Kido and Hiromichi Yumoto :
カルプロテクチンはマウス骨細胞の炎症および骨代謝関連因子の発現を制御する,
第61回春季日本歯周病学会学術大会, Jun. 2018.
18. Masami Ninomiya, Yuji Inagaki, Chie Mihara-Wada, Mika Bandou, Yukiko Nakajima, Eijiro Sakamoto, Ikuta Takahisa, Nishikawa Yasufumi, Jung-Hwan Lew, Kido Rie, Takagi Ryousuke, Nonaka Kouhei, Koji Naruishi, Jun-ichi Kido and Toshihiko Nagata :
新規歯周組織再生剤「リグロス歯科用液キット」の有効性,
四国歯学会 第51回例会, Jun. 2017.
19. Chie Mihara-Wada, Koji Naruishi, Mika Bandou, 西川 泰史, Hwan Jung Lew, Eijiro Sakamoto, 生田 貴久, 河野 薫, Yukari Kajiura, 橋本 万里, Yukiko Nakajima, Yuji Inagaki, Masami Ninomiya, Jun-ichi Kido and Toshihiko Nagata :
アドバンスドOSCEを見据えた当科の模擬OSCEの概要,
Shikoku Dental Research, Vol.29, No.2, 49-53, Jun. 2017.
20. Eijiro Sakamoto, Yuji Inagaki, Jun-ichi Kido, Takagi Ryosuke, Koji Naruishi and Toshihiko Nagata :
最終糖化産物とLPSはMAPKおよびNF-kBを介してマウス骨細胞のスクレロスチンの発現を調節する,
第60回春季日本歯周病学会学術大会, May 2017.
21. Eijiro Sakamoto, Yuji Inagaki, Jun-ichi Kido, 高木 亮輔, 生田 貴久, Koji Naruishi and Toshihiko Nagata :
マウス骨細胞株MLO-Y4-A2のスクレロスチン発現における最終糖化産物およびLPSの影響,
第145回日本歯科保存学会秋季学術大会, Oct. 2016.
22. Mika Bandou, Yukari Kajiura, 野中 康平, Eijiro Sakamoto, Koji Naruishi, Jun-ichi Kido and Toshihiko Nagata :
最終糖化産物はヒト歯肉線維芽細胞におけるIL-6およびICAM-1の発現を増加する,
第59回秋季日本歯周病学会学術大会, Oct. 2016.
23. 美原 智恵, Koji Naruishi, Mika Bandou, 西川 泰史, Jung-Hwan Lew, Eijiro Sakamoto, 生田 貴久, 河野 薫, Yukari Kajiura, 橋本 万里, Yukiko Nakajima, Yuji Inagaki, Masami Ninomiya, Jun-ichi Kido and Toshihiko Nagata :
アドバンスOSCEを見据えた当科の模擬OSCEの概要,
第49回四国歯学会例会, Jun. 2016.
24. 西川 泰史, Koji Naruishi, Yukari Kajiura, Jung-Hwan Lew, Jun-ichi Kido and Toshihiko Nagata :
カルプロテクチンはヒト歯肉線維芽細胞のTLR4を介して炎症性関連因子の発現を亢進する,
第144回日本歯科保存学会春季学術大会, Jun. 2016.
25. Jung-Hwan Lew, Koji Naruishi, Yukari Kajiura, 西川 泰史, Jun-ichi Kido and Toshihiko Nagata :
カロテノイドは高グルコース下で培養したヒト歯肉線維芽細胞のIL-6誘導性タンパク分解酵素産生を抑制する,
第59回春季日本歯周病学会学術大会, May 2016.
26. Jun-ichi Kido, Mika Bandou, Yukiko Nakajima, Yukari Kajiura, Yuji Inagaki, 生田 貴久, Eijiro Sakamoto, Koji Naruishi and Toshihiko Nagata :
ヒト口腔上皮細胞と歯肉線維芽細胞において低酸素環境が誘導する遺伝子発現の比較,
第143回日本歯科保存学会秋季学術大会, Nov. 2015.
27. 吉岡 正太郎, Yoshiteru Tada, Kazuyuki Kuwayama, Kenji Yagi, Junichiro Satomi, 宮本 健志, 北里 慶子, Koji Naruishi, Toshihiko Nagata, Masafumi Harada and Shinji Nagahiro :
歯周病の重症度および原因菌は脳動脈瘤の発生と破裂に関与する,
一般社団法人 日本脳神経外科学会第74回学術総会, Oct. 2015.
28. Yukari Kajiura, Jun-ichi Kido, Yukiko Nakajima, Mika Bandou, Yuji Inagaki, Koji Naruishi, Eijiro Sakamoto, Kaori Abe, Yuka Hiroshima and Toshihiko Nagata :
低酸素環境が誘導するヒト口腔上皮細胞における遺伝子発現の解析,
第58回秋季日本歯周病学会学術大会, Sep. 2015.
29. Eijiro Sakamoto, Jun-ichi Kido, Yukari Kajiura, Mika Bandou, Yuji Inagaki, Koji Naruishi, 生田 貴久 and Toshihiko Nagata :
最終糖化産物はヒト口腔上皮細胞の遺伝子発現を調節する,
第58回秋季日本歯周病学会学術大会, Sep. 2015.
30. Koji Naruishi, Yukari Kajiura, 西川 泰史, Mika Bandou, Jun-ichi Kido and Toshihiko Nagata :
培養歯肉線維芽細胞におけるクリプトタンシノンによる炎症関連分子の生産抑制効果,
第142回日本歯科保存学会春季学術大会, Jun. 2015.
31. 西川 泰史, Koji Naruishi, Yukari Kajiura, Mika Bandou, Jun-ichi Kido and Toshihiko Nagata :
カルプロテクチンがヒト歯肉線維芽細胞の炎症関連因子の発現に及ぼす影響,
第58回春季日本歯周病学会学術大会, May 2015.
32. Jun-ichi Kido, Toshihiko Nagata, Koji Naruishi, 多部田 康一, 山崎 和久, 吉江 弘正, 渡邊 久, 和泉 雄一, 須田 玲子, 山本 松男, 柴 秀樹, 栗原 英見, 柳田 学, 北村 正博, 三島 昭宏, 水野 光春 and 村上 伸也 :
イムノクロマト法を用いた歯肉溝滲出液中のカルプロテクチン測定による歯周病診断ー第2報ー,
第58回春季日本歯周病学会学術大会, May 2015.
33. Masami Ninomiya, Keiji Oishi, Hashimoto Mari, Koji Naruishi and Toshihiko Nagata :
A Cross-Sectional Study on the Progression of Periodontitis in Infective Endocarditis Patients,
日本歯科保存学会 2014年度秋季学術大会(第141回), Oct. 2014.
34. Yukari Kajiura, Yukiko Bandou, Jun-ichi Kido, Mika Bandou, Yuji Inagaki, Yukiko Nakajima, 生田 貴久, Hiromi Murata, Yuka Hiroshima, Koji Naruishi and Toshihiko Nagata :
歯周病および糖尿病患者の歯肉溝滲出液中のYKL-40レベルの検討,
第57回秋季日本歯周病学会学術大会, Oct. 2014.
35. Koji Naruishi :
夜間ブラキシズムによる咬合性外傷によって進行した慢性歯周炎症例,
Journal of the Japanese Association of Periodontology, May 2014.
36. Yukari Kajiura, Yukiko Bandou, Jun-ichi Kido, Mika Bandou, Yuji Inagaki, Yukiko Nakajima, 生田 貴久, Hiromi Murata, Yuka Hiroshima, Koji Naruishi and Toshihiko Nagata :
歯周病および糖尿病患者の歯肉溝滲出液中のYKL-40レベルの検討,
第57回日本歯周病学会秋期学術大会抄録集, May 2014.
37. Koji Naruishi :
歯周病の検査を考える(受賞講演II,岩手医科大学歯学会第73回例会抄録),
Dental journal of Iwate Medical University, Vol.37, No.1, 56, May 2012.
(CiNii: 110009445055)
38. 澤田 俊輔 and Koji Naruishi :
高血糖状態で培養したヒト歯肉線維芽細胞の網羅的な遺伝子解析(一般演題,岩手医科大学歯学会第71回例会抄録),
Dental journal of Iwate Medical University, Vol.36, No.1, 80-81, May 2011.
(CiNii: 110008752167)
39. Koji Naruishi :
歯周疾患を標的とした臨床研究と細胞生物学的アプローチ(特別講演,岩手医科大学歯学会第70回例会抄録),
岩手医科大学歯学雑誌 = Dental journal of Iwate Medical University, Vol.35, No.2, 89, Oct. 2010.
(CiNii: 110007880448)
40. Norihiro SONOI, Hiroshi MAEDA, Koji Naruishi, Susumu KOKEGUCHI, Amgad Wael HASSAN, Koichi SAWADA, Yasushi KOIDE, Kokoro YAMABE, Ichiro TANIMOTO, Hideo ARAI and Shogo TAKASHIBA :
A role of the nrdD-like gene related to abscess-forming ability of Porphyromonas gingivalis,
The Japanese Journal of Conservative Dentistry, Vol.51, 25, May 2008.
(CiNii: 10024178651)
41. Takashi TOMIYAMA, Koji Naruishi, Rosalia MARTINEZ Zulema ARIAS, Keisuke YAMASHIRO, Hiroshi MAEDA, Hideo ARAI and Shogo TAKASHIBA :
Pathophysiology of Periapical Lesions during Root Canal Treatment based on Microarray Analysis in Experimental Rat Periapical Lesions,
The Japanese Journal of Conservative Dentistry, Vol.51, 141, May 2008.
(CiNii: 10024178781)
42. Arias Zulema Rosalia MARTINEZ, Koji Naruishi, Keisuke YAMASHIRO, Kaori MATSUURA, Naoko NAMBA, Hiroshi MAEDA, Hideo ARAI and Shogo TAKASHIBA :
Gene Profiles during Root Canal Treatment in Experimental Periapical Lesions,
The Japanese Journal of Conservative Dentistry, Vol.50, 155, May 2007.
(CiNii: 10020162679)
43. Hideo ARAI, Ichiro TANIMOTO, Yoshihiro IWAMOTO, Yasushi KOIDE, Kazuya TOMIKAWA, Takashi TOMIYAMA, Masayuki SHIMOE, Norihiro SONOI, Koji Naruishi and Shogo TAKASHIBA :
Evaluation of E-learning System for Clinical Education of Periodontology & Endodontology,
The Japanese Journal of Conservative Dentistry, Vol.49, 175, Oct. 2006.
(CiNii: 10020294985)
44. Tomoko YAMAGUCHI, Koji Naruishi, Hideo ARAI, Hidenori Nishimura and Shogo TAKASHIBA :
Caveolin-1 Mediates IL-6/sIL-6R-induced Cathepsin-B, -L Activation in Human Gingival Fibroblasts,
Journal of the Japanese Association of Periodontology, Vol.48, 149, Mar. 2006.
(CiNii: 10018119633)
45. Keisuke YAMASHIRO, Koji Naruishi, Akiko YAMASHITA, Kyoko SENOO, Tomoko YAMAGUCHI, Fumio MYOKAI, Hideo ARAI, Hidenori Nishimura and Shogo TAKASHIBA :
Microarray Analysis of Gene Expression Profiles Induced by High Glucose in Human Gingival Fibroblasts,
Journal of the Japanese Association of Periodontology, Vol.48, 197, Mar. 2006.
(CiNii: 10018119680)
46. Kazuhiro OMORI, Koji Naruishi, Hidenori Nishimura, Hisa NARUISHI YAMADA, Mayumi YAMAGUCHI, Hideo ARAI and Shogo TAKASHIBA :
High glucose enhances IL-6 induced VEGF expression via activation of gp130 mediated p44/42 MAPK-C/EBP signaling in human gingival fibroblasts,
Journal of the Japanese Association of Periodontology, Vol.45, 139, Sep. 2003.
(CiNii: 10013972663)
47. Mayumi YAMAGUCHI, Hidenori Nishimura, Koji Naruishi, Kazuhiro OMORI, Hisa NARUISHI and Shogo TAKASHIBA :
Anti-angiogenic Effect of Cyclosporine-A is Mediated by the Suppression of VEGF Production via Decreased JNK Activity,
Journal of the Japanese Association of Periodontology, Vol.45, 140, Sep. 2003.
(CiNii: 10013972664)
48. Mayumi YAMAGUSHI, Hidenori Nishimura, Hisa NARUISHI, Yoshihiko SOGA, Susumu KOKEGUCHI, Koji Naruishi and Shogo TAKASHIBA :
Lipopolysaccharide from Periodontal Bacteria Enhances TNF- Production in 3T3-L1 Adipocytes,
Journal of the Japanese Association of Periodontology, Vol.45, 96, Apr. 2003.
(CiNii: 10010759954)
49. Kazuhiro OMORI, Koji Naruishi, Hidenori Nishimura, Hisa YAMADA-NARUISHI, Mayumi YAMAGUCHI, Hideo ARAI and Shogo TAKASHIBA :
High glucose enhances IL-6/sIL-6R induced VEGF production in human gingival fibroblast,
The Japanese Journal of Conservative Dentistry, Vol.45, 60, Oct. 2002.
(CiNii: 50000660537)
50. Hidenori Nishimura, Hisa Naruishi, Koji Naruishi, Shogo Takashiba and Yoji Murayama :
Cathepsin-L deficient mice develop gingival overgrowth,
Journal of the Japanese Association of Periodontology, Vol.44, No.0, 91, Sep. 2002.
(CiNii: 110003992489)
51. Hisa YAMADA, Hidenori Nishimura, Koji Naruishi, Shogo TAKASHIBA and Yoji MURAYAMA :
Ca^<2+> Blocker Nifedipine Suppress Cathepsin L Activity in Gingival Fibroblasts in vitro,
The Japanese Journal of Conservative Dentistry, Vol.44, 96, Apr. 2001.
(CiNii: 10012356964)
52. Koji Naruishi, S. TAKASHIBA, Hidenori Nishimura, H. YAMADA, H. ARAI and Y. MURAYAMA :
Regulation of Cathepsin B and L Activation via IL-6/sIL-6R-Induced p44/42 MAPK in Gingival Fibroblasts,
Journal of the Japanese Association of Periodontology, Vol.43, No.0, 159, Mar. 2001.
(CiNii: 110003992417)
53. Hisa YAMADA, Hidenori Nishimura, Koji Naruishi and Yoji MURAYAMA :
Phenytoin Suppresses Matrix-degrading Enzyme Cathepsin-L Activity in Gingival Fibroblasts,
Tissue culture research communications : the journal of experimental & applied cell culture research = 組織培養研究, Vol.19, No.2, 91, Jun. 2000.
(CiNii: 10013208375)
54. Yoshihiko SOGA, Hidenori Nishimura, Kyoko KATSURAGI, Koji Naruishi, Hisa YAMADA, Hideaki SATO, Shogo TAKASHIBA and Yoji MURAYAMA :
An Early-Onset Periodontitis Patient with Aberrant Expression of 2-integrin,
The Japanese Journal of Conservative Dentistry, Vol.42, 77, Oct. 1999.
(CiNii: 10005979348)
55. Hisa YAMADA, Hidenori Nishimura, Koji Naruishi, Yoshitomo KOBAYASHI, Shogo TAKASHIBA and Yoji MURAYAMA :
Oral Disease Status of the Patients Receiving Phenytoin Therapy,
The Japanese Journal of Conservative Dentistry, Vol.42, 203, Oct. 1999.
(CiNii: 10005979492)
56. Shogo TAKASHIBA, Taisuke OHIRA, Fumio MYOKAI, Masataka OYAMA, Koji Naruishi and Yoji MURAYAMA :
Genes Expressed Uniquely during Wound Healing in Dental Pulp Tissue,
The Japanese Journal of Conservative Dentistry, Vol.42, 17, Apr. 1999.
(CiNii: 10005686475)
57. Masataka OYAMA, Koji Naruishi, Taisuke OHIRA, Fumio MYOKAI, Shogo TAKASHIBA and Yoji MURAYAMA :
Experimental Studies on Gene Transfer to Dental Pulp Cells,
The Japanese Journal of Conservative Dentistry, Vol.42, 18, Apr. 1999.
(CiNii: 10005686477)
58. Akemi SHIMIZU, Hidenori Nishimura, Koji Naruishi, Satoko SAWADA, Chiyo FUJIMOTO, Junji MINESHIBA, Shogo TAKASHIBA and Yoji MURAYAMA :
A Case Study of Compromized Host Who Died After Periodontal Treatment,
Journal of the Japanese Association of Periodontology, Vol.41, No.1, 180, Mar. 1999.
(CiNii: 10005979810)
59. H. Ohyama, Hidenori Nishimura, Koji Naruishi, S. Takashiba and Y. Murayama :
The roles of HLA class II molecules expressed on periodontal ligament cells,
Journal of the Japanese Association of Periodontology, Vol.41, No.0, 89, Mar. 1999.
(CiNii: 110003991928)
60. Hyogo Ohe, Koji Naruishi, Norifumi Washio, Hideo Arai, Hidenori Nishimura, Shogo Takashiba and Yoji Murayama :
Production of Soluble TNF Receptor form Human Gingival Fibroblasts Stimulated by Inflammatory Cytokines,
Journal of the Japanese Association of Periodontology, Vol.41, No.0, 107, Mar. 1999.
(CiNii: 110003991946)
61. Fumio MYOKAI, Taisuke OHIRA, Tadashi YAMAMOTO, Junji MINESHIBA, Norifumi WASHIO, Koji Naruishi, Hideo ARAI, Hidenori Nishimura, Shogo TAKASHIBA and Yoji MURAYAMA :
Study of Unique Genes Expressed by Mechanical Stress in Human Periodontal Ligament Fibroblasts,
Journal of the Japanese Association of Periodontology, Vol.40, No.0, 108, Sep. 1998.
(CiNii: 110003991487)
62. Hisa Yamada, Hidenori Nishimura, Koji Naruishi, Shogo Takashiba and Yoji Murayama :
Cyclosporin A and phenytoin suppress matrix-degrading enzyme activity in gingival fibroblasts in vitro,
Journal of the Japanese Association of Periodontology, Vol.40, No.0, 112, Sep. 1998.
(CiNii: 110003991491)
63. Taisuke OHIRA, Fumio MYOKAI, Koji Naruishi, Tadashi YAMAMOTO, Hideo ARAI, Hidenori Nishimura, Shogo TAKASHIBA and Yoji MURAYAMA :
Expression Pattern of Serum and Glucocorticoid-Inducible Kinase (sgk) during Rat Dental Hard Tissue Formation,
The Japanese Journal of Conservative Dentistry, Vol.41, 32, May 1998.
(CiNii: 10005976337)
64. Koji Naruishi, Shogo TAKASHIBA, Masayuki TAKIGAWA, Hidenori Nishimura, Hideo ARAI and Yoji MURAYAMA :
IL-6-induced signals via soluble IL-6 receptor in gingival fibroblasts,
The Japanese Journal of Conservative Dentistry, Vol.40, 62, May 1997.
(CiNii: 10005683081)
65. Hiromasa OMURO, Masayuki TAKIGAWA, Kazunori OKAMURA, Hidenori Nishimura, Koji Naruishi, Takamasa SAWA, Tadashi YAMAMOTO, Taisuke OHIRA, Keiso TAKAHASHI, Shun Guo JUAN, Shogo TAKASHIBA and Yoji MURAYAMA :
A Case Study of family Members Manifesting Early-Onset Periodontitis with Gingival Overgrowth ~Clinical, Microbiological, Immunological and Histological Observation~,
The Japanese Journal of Conservative Dentistry, Vol.40, 154, May 1997.
(CiNii: 10005683190)
66. Koji Naruishi, Hideo Arai, Shogo Takashiba, Masayuki Takigawa, Norifumi Washio, H.Hsin-Hua Chou, Hyogo Ohe, Yoji Asahara, Yutaka Higuchi, Hidemi Kuriahra and Yoji Murayama :
Role of Soluble IL-6 Receptor on IL-6 Signal Transduction in Human Gingival Fibroblast,
Journal of the Japanese Association of Periodontology, Vol.37, No.0, 96, Apr. 1995.
(CiNii: 110003990835)

Et cetera, Workshop:

1. Masami Ninomiya, Eijiro Sakamoto, Koji Naruishi and Hiromichi Yumoto :
周期性好中球減少症患者に発症した重度歯周炎の家族症例,
第1回侵襲性歯周炎センター クリニカルカンファレンス, Dec. 2018.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Pathophysiology of periodontitis progression by IL-1 and geriatric impaired testosterone in diabetic patients (Project/Area Number: 19K10131 )
  • 人工細胞を用いたオーラルケアシステムの基礎研究 (Project/Area Number: 17H04418 )
  • Crosstalk of Gingival Fibroblasts and Macrophages in Inflammatory Cytokine Cascade: Potential Mechanisms of Periodontitis with Diabetes. (Project/Area Number: 16K11832 )
  • Diagnosis of peri-implant diseases by cellular biomarkers and development of diagnostic device (Project/Area Number: 15K15767 )
  • Effect of advanced glycation end-products and inflammasome for pathogenesis of Diabetes mellitus-associated periodontitis (Project/Area Number: 15K11391 )
  • Pathophysiology of diebetes-associated periodontitis and establishment of novel diagnosis system of diabetes-associated periodontitis (Project/Area Number: 15H05054 )
  • AP-1によるカテプシン産生制御に着目した歯肉増殖症・歯周病診断の新機軸 (Project/Area Number: 24659926 )
  • How periodontitis can affect prostate cancer metastasis? (Project/Area Number: 22592312 )
  • Chronic infection and immune response in COPD patients (Project/Area Number: 21590964 )
  • Investigation of the mechanisms of osteogenic differentiation by RhoA in periodontal ligament cells for cell transplantation (Project/Area Number: 20592429 )
  • Possible Mechanisms of Progression of Periodontits by MMP-3 in Diabetic Patients (Project/Area Number: 20592428 )
  • Healing mechanism of rat experimental periapical lesions targeting laminin γ2 expression (Project/Area Number: 20592226 )
  • New bactericide delivery system for oral care (Project/Area Number: 19592201 )
  • 糖尿病患者の歯周病悪化を誘発する新規因子の網羅的な解析および同定 (Project/Area Number: 18791592 )
  • Mail Medicine using Fingertip Plasma for Screening and Monitoring Periodontitis (Project/Area Number: 18209061 )
  • The effect on dentin-pulp complex by FIP-2 isolated from rat wounded pulp (Project/Area Number: 17591991 )
  • Study for oral infectious control during peripheral blood stem cell transplantation (Project/Area Number: 13672186 )
  • Search by Researcher Number (00346446)