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Tokushima University > Research Clusters > Research Clusters (Registered) > 2004005 治療法・予防法の開発を指向した老化を定量する技術の開発 >
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Research Activity

His Web Page

Field of Study

Molecular Biology

Subject of Study

脂溶性ビタミン・ステロイドホルモンによる核内受容体転写機構の研究

Book / Paper

Academic Paper (Judged Full Paper):

1. Maria Tsoumpra, Shun Sawatsubashi, Michihiro Imamura, Seiji Fukumoto, Shin'ichi Takeda, Toshio Matsumoto and Yoshitsugu Aoki :
Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle.,
Journal of Molecular Endocrinology, Vol.64, No.3, 195-208, 2020.
(DOI: 10.1530/JME-19-0229,   PubMed: 31940280)
2. Seiji Fukumoto, Yuichi Takashi, Maria Tsoumpra, Shun Sawatsubashi and Toshio Matsumoto :
How do we sense phosphate to regulate serum phosphate level?,
Journal of Bone and Mineral Metabolism, Vol.38, No.1, 1-6, 2020.
(DOI: 10.1007/s00774-019-01066-0,   PubMed: 31797064)
3. Yuichi Takashi, Hidetaka Kosako, Shun Sawatsubashi, Yuka Kinoshita, Nobuaki Ito, Maria K. Tsoumpra, Masaomi Nangaku, Masahiro Abe, Munehide Matsuhisa, Shigeaki Kato, Toshio Matsumoto and Seiji Fukumoto :
Activation of unliganded FGF receptor by extracellular phosphate potentiates proteolytic protection of FGF23 by its O-glycosylation,
Proceedings of the National Academy of Sciences of the United States of America, Vol.116, No.23, 11418-11427, 2019.
(Tokushima University Institutional Repository: 113621,   DOI: 10.1073/pnas.1815166116,   PubMed: 31097591)
4. Shun Sawatsubashi, Yudai Joko, Seiji Fukumoto, Toshio Matsumoto and Shigeo S. Sugano :
Development of versatile non-homologous end joining-based knock-in module for genome editing.,
Scientific Reports, Vol.8, No.1, 593, 2018.
(Tokushima University Institutional Repository: 112400,   DOI: 10.1038/s41598-017-18911-9,   PubMed: 29330493,   Elsevier: Scopus)
5. Saya Ito, Sally Fujiyama-Nakamura, Shuhei Kimura, Jinseon Lim, Yuki Kamoshida, Yumi Shiozaki-Sato, Shun Sawatsubashi, Eriko Suzuki, Masahiko Tanabe, Takashi Ueda, Takuya Murata, Hiromi Kato, Fumiaki Ohtake, Ryoji Fujiki, Tsuneharu Miki, Alexander Kouzmenko, Ken-Ichi Takeyama and Shigeaki Kato :
Epigenetic silencing of core histone genes by HERS in Drosophila.,
Molecular Cell, Vol.45, No.4, 494-504, 2012.
(DOI: 10.1016/j.molcel.2011.12.029,   PubMed: 22365829)
6. Shun Sawatsubashi, Takuya Murata, Jinseon Lim, Ryoji Fujiki, Saya Ito, Eriko Suzuki, Masahiko Tanabe, Yue Zhao, Shuhei Kimura, Sally Fujiyama, Takashi Ueda, Daiki Umetsu, Takashi Ito, Ken-ichi Takeyama and Shigeaki Kato :
A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor.,
Genes & Development, Vol.24, No.2, 159-170, 2009.
(DOI: 10.1101/gad.1857410,   PubMed: 20040570)
7. Sally Fujiyama-Nakamura, Saya Ito, Shun Sawatsubashi, Yoshio Yamauchi, Eriko Suzuki, Masahiko Tanabe, Shuhei Kimura, Takuya Murata, Toshiaki Isobe, Ken-ichi Takeyama and Shigeaki Kato :
BTB protein, dKLHL18/CG3571, serves as an adaptor subunit for a dCul3 ubiquitin ligase complex.,
Genes to Cells, Vol.14, No.8, 965-973, 2009.
(DOI: 10.1111/j.1365-2443.2009.01323.x,   PubMed: 19624754)
8. Eriko Suzuki, Yue Zhao, Saya Ito, Shun Sawatsubashi, Takuya Murata, Takashi Furutani, Yuko Shirode, Kaoru Yamagata, Masahiko Tanabe, Shuhei Kimura, Takashi Ueda, Sally Fujiyama, Jinseon Lim, Hiroyuki Matsukawa, P Alexander Kouzmenko, Toshiro Aigaki, Tetsuya Tabata, Ken-ichi Takeyama and Shigeaki Kato :
Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.10, 3818-3822, 2009.
(DOI: 10.1073/pnas.0809819106,   PubMed: 19237573)
9. Yue Zhao, Ken-ichi Takeyama, Shun Sawatsubashi, Saya Ito, Eriko Suzuki, Kaoru Yamagata, Masahiko Tanabe, Shuhei Kimura, Sally Fujiyama, Takashi Ueda, Takuya Murata, Hiroyuki Matsukawa, Yuko Shirode, P Alexander Kouzmenko, Feng Li, Testuya Tabata and Shigeaki Kato :
Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system.,
Molecular and Cellular Biology, Vol.29, No.4, 1017-1034, 2008.
(DOI: 10.1128/MCB.02123-07,   PubMed: 19075001)
10. Takuya Murata, Eriko Suzuki, Saya Ito, Shun Sawatsubashi, Yue Zhao, Kaoru Yamagata, Masahiko Tanabe, Sally Fujiyama, Shuhei Kimura, Takashi Ueda, Hiroyuki Matsukawa, Alexander Kouzmenko, Takashi Furutani, Erina Kuranaga, Masayuki Miura, Ken-ichi Takeyama and Shigeaki Kato :
RNA-binding protein hoip accelerates polyQ-induced neurodegeneration in Drosophila.,
Bioscience, Biotechnology, and Biochemistry, Vol.72, No.9, 2255-2261, 2008.
(DOI: 10.1271/bbb.70829,   PubMed: 18776683)
11. Shuhei Kimura, Shun Sawatsubashi, Saya Ito, Alexander Kouzmenko, Eriko Suzuki, Yue Zhao, Kaoru Yamagata, Masahiko Tanabe, Takashi Ueda, Sari Fujiyama, Takuya Murata, Hiroyuki Matsukawa, Ken-Ichi Takeyama, Nobuo Yaegashi and Shigeaki Kato :
Drosophila arginine methyltransferase 1 (DART1) is an ecdysone receptor co-repressor.,
Biochemical and Biophysical Research Communications, Vol.371, No.4, 889-893, 2008.
(DOI: 10.1016/j.bbrc.2008.05.003,   PubMed: 18468516)
12. Yue Zhao, Guillaume Lang, Saya Ito, Jacques Bonnet, Eric Metzger, Shun Sawatsubashi, Eriko Suzuki, Xavier Guezennec Le, G Hendrik Stunnenberg, Aleksey Krasnov, G Sofia Georgieva, Roland Schüle, Ken-Ichi Takeyama, Shigeaki Kato, László Tora and Didier Devys :
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing.,
Molecular Cell, Vol.29, No.1, 92-101, 2008.
(DOI: 10.1016/j.molcel.2007.12.011,   PubMed: 18206972)
13. P Alexander Kouzmenko, Ken-Ichi Takeyama, Saya Ito, Takashi Furutani, Shun Sawatsubashi, Akio Maki, Eriko Suzuki, Yoshihiro Kawasaki, Tetsu Akiyama, Testuya Tabata and Shigeaki Kato :
Wnt/beta-catenin and estrogen signaling converge in vivo.,
The Journal of Biological Chemistry, Vol.279, No.39, 40255-40258, 2004.
(DOI: 10.1074/jbc.C400331200,   PubMed: 15304487)
14. Akio Maki, Shun Sawatsubashi, Saya Ito, Yuko Shirode, Eriko Suzuki, Yue Zhao, Kaoru Yamagata, Alexander Kouzmenko, Ken-Ichi Takeyama and Shigeaki Kato :
Juvenile hormones antagonize ecdysone actions through co-repressor recruitment to EcR/USP heterodimers.,
Biochemical and Biophysical Research Communications, Vol.320, No.1, 262-267, 2004.
(DOI: 10.1016/j.bbrc.2004.05.156,   PubMed: 15207730)
15. Shun Sawatsubashi, Akio Maki, Saya Ito, Yuko Shirode, Eriko Suzuki, Yue Zhao, Kaoru Yamagata, Alexander Kouzmenko, Ken-Ichi Takeyama and Shigeaki Kato :
Ecdysone receptor-dependent gene regulation mediates histone poly(ADP-ribosyl)ation.,
Biochemical and Biophysical Research Communications, Vol.320, No.1, 268-272, 2004.
(DOI: 10.1016/j.bbrc.2004.05.157,   PubMed: 15207731)
16. Akinori Ishihara, Shun Sawatsubashi and Kiyoshi Yamauchi :
Endocrine disrupting chemicals: interference of thyroid hormone binding to transthyretins and to thyroid hormone receptors.,
Molecular and Cellular Endocrinology, Vol.199, No.1-2, 105-117, 2003.
(DOI: 10.1016/S0303-7207(02)00302-7,   PubMed: 12581883)
17. N Nishiyama, Shun Sawatsubashi, M Ishida and K Yamauchi :
Organization and expression of the Paramecium caudatum gene encoding nucleosome assembly protein 1.,
Gene, Vol.280, No.1-2, 107-114, 2001.
(PubMed: 11738823)

Review, Commentary:

1. Shun Sawatsubashi :
[Update on recent progress in vitamin D research. Vitamin D in the treatment of psoriasis.],
Clinical Calcium, Vol.27, No.11, 1629-1635, Nov. 2017.
(PubMed: 29074837)
2. Shun Sawatsubashi :
[Hair follicle stem cells.],
Clinical Calcium, Vol.27, No.6, 803-808, Jun. 2017.
(PubMed: 28536317)
3. Shun Sawatsubashi :
[Bone and Nutrition. The vitamin D functions in osteoblasts and osteocytes].,
Clinical Calcium, Vol.25, No.7, 991-997, Jul. 2015.
(PubMed: 26119311)
4. Shun Sawatsubashi :
[Current Topics on Vitamin D. The vitamin D functions in keratinocytes and its therapeutic applications].,
Clinical Calcium, Vol.25, No.3, 367-371, Mar. 2015.
(PubMed: 25716809)

Proceeding of International Conference:

1. Yuichi Takashi, Yuka Kinoshita, Nobuaki Ito, Shun Sawatsubashi, Hidetaka Kosako, Masahiro Abe, Munehide Matsuhisa, Toshio Matsumoto and Seiji Fukumoto :
FGF receptor 1c works as a phosphate-sensor to regulate FGF23 production,
ASBMR 2018 Annual Meeting Registration Confirmation, Sep. 2018.

Proceeding of Domestic Conference:

1. Shun Sawatsubashi, Toshio Matsumoto and Seiji Fukumoto :
栄養情報が調節するグルココルチコイド受容体の転写制御機構の解析,
第93回日本内分泌学会学術総会, Vol.96, No.1, 238, Jul. 2020.
2. Yuichi Takashi, Shun Sawatsubashi, Itsuro Endo, Masahiro Abe, Munehide Matsuhisa, Toshio Matsumoto and Seiji Fukumoto :
FGFR1は血中FGF23濃度を制御するリン感知受容体である,
第38回日本骨代謝学会学術集会, Oct. 2019.
3. Yuichi Takashi, Hidetaka Kosako, Shun Sawatsubashi, Y Kinoshita, N Ito, Munehide Matsuhisa, M Matsumoto and Seiji Fukumoto :
FGF recepotor I works as a phosphate-sensor to regulate FGF23 production,
15th Bone Biology Forum, Aug. 2019.
4. Yuichi Takashi, Hidetaka Kosako, Shun Sawatsubashi, Yuka Kinoshita, 伊東 伸朗, Masahiro Abe, Munehide Matsuhisa, Shigeaki Kato, Toshio Matsumoto and Seiji Fukumoto :
FGFR1はFGF23濃度調節を媒介するリン感知受容体である,
第92回日本内分泌学会学術総会, Vol.95, No.1, 333, May 2019.

Patent:

1. Shun Sawatsubashi and Sigeo Sugano : ゲノム編集方法, 2017-027384 (Feb. 2017), .

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Study on the actions of phosphate as a first messenger (Project/Area Number: 19H03676 )
  • Non-coding領域に存在する疾患原因SNPの同定と機能解析 (Project/Area Number: 18KT0024 )
  • ビタミンD依存性くる病モデルマウスから切り拓く毛周期破綻による脱毛機序の解明 (Project/Area Number: 18K19518 )
  • Role of vitamin D receptor target genes in the epidermal function and hair follicle homeostasis. (Project/Area Number: 16K19556 )
  • Innovation of novel therapeutics against diabetic nephropathy targeting ChREBP (Project/Area Number: 16K15492 )
  • Role and mechanism of action of IL-11 on the regulation of bone and adipose tissue interaction (Project/Area Number: 16H05327 )
  • Glucose regulates the function of glucocorticoid receptor via O-GlcNAc modification. (Project/Area Number: 24591357 )
  • 慢性炎症病態を制御するシグナル依存性エピゲノム制御メカニズムの解析 (Project/Area Number: 23117505 )
  • A genetical screening of a protein trap library for active chromatin-binding factors on polytene chromosome in Drosophila (Project/Area Number: 22770166 )
  • Search by Researcher Number (70535103)