Tokushima University / Educator and Researcher Directory --- Miyagi, Mayu

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https://researchmap.jp/mayu_miyagi (researchmap)

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Yoshitaka Suzuki, Kazuo Okura, Toyoko Tajima, Junhel Dalanon, Masamitsu Ohshima, Maki Hosoki, Miho Inoue, Mayu Miyagi, Daisuke Ikutame and Yoshizo Matsuka : Essence of diagnosis and management of sleep bruxism, Journal of Oral Health and Biosciences, Vol.36, No.2, 22-29, 2024. (Tokushima University Institutional Repository) ● Metadata: 119296 (Tokushima University Institutional Repository: 119296)
2.	Maki Hosoki, Yoshifumi Okamoto, Toyoko Tajima, Mayu Miyagi, Yoshiaki Kubo, Maiko Sogawa, R Raju, S Afroz and Yoshizo Matsuka : Risk of an immediate-type allergy to minocycline hydrochloride ointment, Operative Dentistry, Endodontology and Periodontology, Vol.3, No.1, 152-157, 2023. (Link to Publication Site) ● Publication site (DOI): 10.11471/odep.2023-018 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11471/odep.2023-018 (DOI: 10.11471/odep.2023-018)
3.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Toyoko Tajima, Mayu Miyagi, S Raman, R Raju and Yoshizo Matsuka : Identification of microRNA signatures in peripheral blood of young women as potential biomarkers for metal allergy, Biomedicines, Vol.11, No.2, 277, 2023. (Summary) MicroRNA (miRNA) is a short (19-24 nucleotide) endogenous non-protein RNA that exists in the body and controls the translation process from genes to proteins. It has become useful as a diagnostic tool and a potential treatment target in cancer research. To explore the function of miRNA in contact dermatitis, female participants with a positive metal allergy diagnosis ( = 3) were enrolled along with additional female participants with no medical history of metal allergy ( = 3). A patch test was performed on each participant. Peripheral blood was collected from all the participants before the patch test and at days 3 and 7 after starting the patch test. After total RNA was obtained from peripheral blood leukocytes and cDNA was generated, microarray analysis was performed to analyze the large-scale circulating miRNA profile. Real-time polymerase chain reaction (RT-PCR) was then used to clarify the overall target miRNA expression. Downregulation of hsa-let-7d-5p, hsa-miR-24-3p, hsa-miR-23b-3p, hsa-miR-26b-5p, and hsa-miR-150-5p was found on day 7. Certain miRNAs were confirmed using RT-PCR. These peripheral blood miRNAs could be diagnostic biomarkers for metal allergies. (Tokushima University Institutional Repository) ● Metadata: 117923 (Link to Publication Site) ● Publication site (DOI): 10.3390/biomedicines11020277 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36830814 ● Search Scopus @ Elsevier (PMID): 36830814 ● Search Scopus @ Elsevier (DOI): 10.3390/biomedicines11020277 (Tokushima University Institutional Repository: 117923, DOI: 10.3390/biomedicines11020277, PubMed: 36830814)
4.	Huijiao Yan, Masamitsu Ohshima, Raju Raju, S Raman, Kazumitsu Sekine, Arief Waskitho, Miho Inoue, Masahisa Inoue, Otto Baba, Tsuyoshi Morita, Mayu Miyagi and Yoshizo Matsuka : Dentin-pulp complex tissue regeneration via three-dimensional cell sheet layering, Tissue Engineering. Part C, Methods, Vol.27, No.10, 559-570, 2021. (Summary) The dentin-pulp complex is a unique structure in teeth that contains both hard and soft tissues. Generally, deep caries and trauma cause damage to the dentin-pulp complex, and if left untreated, this damage will progress to irreversible pulpitis. The aim of this study was to fabricate a layered cell sheet composed of rat dental pulp (DP) cells and odontogenic differentiation of pulp (OD) cells and to investigate the ability to regenerate the dentin-pulp complex in a scaffold tooth. We fabricated two single cell sheets composed of DP cells (DP cell sheet) or OD cells (OD cell sheet) and a layered cell sheet made by layering both cells. The characteristics of the fabricated cell sheets were analyzed using light microscopy, scanning electron microscope (SEM), hematoxylin-eosin (HE) staining, and immunohistochemistry (IHC). Furthermore, the cell sheets were transplanted into the subrenal capsule of immunocompromised mice for 8 weeks. After this, the regenerative capacity to form dentin-like tissue was evaluated using micro-computed tomography (micro-CT), HE staining, and IHC. The findings of SEM and IHC confirmed that layered cell sheets fabricated by stacking OD cells and DP cells maintained their cytological characteristics. Micro-CT of layered cell sheet transplants revealed a mineralized capping of the access cavity in the crown area, similar to that of natural dentin. In contrast, the OD cell sheet group demonstrated the formation of irregular fragments of mineralized tissue in the pulp cavity, and the DP cell sheet did not develop any hard tissue. Moreover, bone volume/tissue volume (BV/TV) showed a significant increase in hard tissue formation in the layered cell sheet group compared with that in the single cell sheet group ( < 0.05). HE staining also showed a combination of soft and hard tissue formation in the layered cell sheet group. Furthermore, IHC confirmed that the dentin-like tissue generated from the layered cell sheet expressed characteristic markers of dentin but not bone equivalent to that of a natural tooth. In conclusion, this study demonstrates the feasibility of regenerating dentin-pulp complex using a bioengineered tissue designed to simulate the anatomical structure. Impact statement The dentin-pulp complex can be destroyed by deep caries and trauma, which may cause pulpitis and progress to irreversible pulpitis, apical periodontitis, and even tooth loss. Current treatments cannot maintain pulp health, and teeth can become brittle. We developed a three-dimensional (3D) layered cell sheet using dental pulp cells and odontogenic differentiation of pulp cells for dentin-pulp complex regeneration. Our layered cell sheet enables the regeneration of an organized 3D dentin-pulp-like structure comparable with that of natural teeth. This layered cell sheet technology may contribute to dentin-pulp complex regeneration and provide a novel method for complex tissue engineering. (Tokushima University Institutional Repository) ● Metadata: 117029 (Link to Publication Site) ● Publication site (DOI): 10.1089/ten.TEC.2021.0171 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34583551 ● Search Scopus @ Elsevier (PMID): 34583551 ● Search Scopus @ Elsevier (DOI): 10.1089/ten.TEC.2021.0171 (Tokushima University Institutional Repository: 117029, DOI: 10.1089/ten.TEC.2021.0171, PubMed: 34583551)
5.	Rika Hayama, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Takuma Iwasa, Junhel Dalanon, Raju Resmi, Omar Maningo Rodis and Yoshizo Matsuka : Longitudinal comparison between flipped classroom and team-based learning in a prosthodontic class, Journal of Oral Health and Biosciences, Vol.34, No.1, 1-10, 2021. (Summary) Active learning is a concept that allows students to study and learn actively by themselves to get knowledge. There are several methods of active learning, including flipped classroom (FC) and team-based learning (TBL). In FC, students are required to study before classes. In TBL, students also study before class, take individual readiness assurance test (iRAT) and team readiness assurance test (tRAT), then discuss group assignment projects (GAPs) during class. The purpose of this study was to compare the effectiveness between FC and TBL.<br> The effectiveness of FC and TBL was assessed from the results of the term-end examinations, questionnaires and practice examinations. To check the difficulty of the term-end examinations, control dentists took the same examinations and we calculated the equating score with item response theory.<br> Statistical analysis showed that the correct answer rate in term-end examinations was significantly different in comparison with the time of the trial, and for the participants (students and dentists). The term-end examination score of FC and TBL did not show a statistical difference. The student questionnaire showed that TBL had higher scores than FC on various factors such as student positive attitude, preparation, ingenuity of teacher and achieving the class goals. The crown & bridge score from the practice examination of 6<sup>th</sup>-year students who had FC + TBL were constantly higher than the Japanese national average score. The identification index of FC and TBL did not show the statistical difference and there was no statistical difference on item response theory between FC and TBL. (Keyword) Flipped classroom / Team-based learning / Prosthodontics (Tokushima University Institutional Repository) ● Metadata: 116284 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.34.1_1 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390852259674142080 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.34.1_1 (Tokushima University Institutional Repository: 116284, DOI: 10.20738/johb.34.1_1, CiNii: 1390852259674142080)
6.	Yoshizo Matsuka, Masamitsu Ohshima, Kazuo Okura, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi and Miho Inoue : インドネシアの歯学部における学部教育, The Journal of Japan Association of Oral Rehabilitation, Vol.33, No.1, 53-57, 2020. (Keyword) Undergraduate student education / dental school / Indonesia (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572359516377600 (CiNii: 1520572359516377600)
7.	Haruna Miki, Hajime Minakuchi, Mayu Miyagi, Satoshi Emilio Hara, Shuji Shigemoto, Yoshitaka Suzuki, Kenji Maekawa, Yoshizo Matsuka, GT Clark and Takuo Kuboki : Association of masticatory muscle activity with sleep arousal and other concomitant movements during sleep, Journal of Oral Rehabilitation, Vol.47, No.3, 281-288, 2020. (Summary) This study aims to verify the associations among sleep bruxism (SB), sleep arousal (SA) and concurrent body movements. Subjects underwent a standard overnight polysomnography test and audio-video recordings. Sleep quality was evaluated according to the Rechtschaffen and Kales criteria, while SA was determined as per the American Sleep Disorders Association criteria. Analyses were performed by an external institution after masking of the subjects' information. SB was assessed based on the presence/absence of rhythmic masticatory muscle activity (RMMA) episodes, which were identified by using electromyography of the masseter muscle. The observed simultaneous movements included lower leg movement (LLM), swallowing, face scratching, head movement, body movement, eye blinking, coughing, licking, sighing, body scratching, lip sucking, somniloquy and yawning. The LLM was determined visually, as well as through an increase in the tibialis electromyogram signal. Other movements were visually assessed using audio-video recordings. The incidences of all the simultaneous movements were compared between RMMA with intercurrent SA (SAwRMMA; RMMA episode derived from a masseter electromyogram showing more than 10% of maximum voluntary contraction) and SA without RMMA (SAw/oRMMA). Fourteen subjects were included in this study (females/males: 4/10, mean age: 31.5 ± 5.7 years). Among these, LLM, swallowing, body movement, licking, body scratching and lip sucking were frequently observed in SAwRMMA episodes than in SAw/oRMMA episodes, significantly. However, the non-specific simultaneous movements were higher observed in SAw/oRMMA episodes than that in SAwRMMA. Our results suggest that SB is concurrently activated with LLM in relation to arousal. (Keyword) Adult / Arousal / Electromyography / Female / Humans / Male / Masseter Muscle / Masticatory Muscles / Polysomnography / Sleep / Sleep Bruxism (Link to Publication Site) ● Publication site (DOI): 10.1111/joor.12913 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31746005 ● Search Scopus @ Elsevier (PMID): 31746005 ● Search Scopus @ Elsevier (DOI): 10.1111/joor.12913 (DOI: 10.1111/joor.12913, PubMed: 31746005)
8.	Mio Naritani, Miho Inoue, Resmi Raju, Mayu Miyagi, Masamitsu Ohshima and Yoshizo Matsuka : Analysis of Bone Marrow-derived Mesenchymal Stem Cell Kinetics after Short-term Stimulation with Tumor Necrosis Factor-α (TNF-α), Journal of Hard Tissue Biology, Vol.28, No.2, 99-108, 2019. (Tokushima University Institutional Repository) ● Metadata: 113372 (Link to Publication Site) ● Publication site (DOI): 10.2485/jhtb.28.99 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85065527448 (Tokushima University Institutional Repository: 113372, DOI: 10.2485/jhtb.28.99, Elsevier: Scopus)
9.	Maki Hosoki, Keisuke Nishigawa, Toyoko Tajima, Mayu Miyagi and Yoshizo Matsuka : Cross-sectional observational study exploring clinical risk of titanium allergy caused by dental implants, Journal of Prosthodontic Research, Vol.62, No.4, 426-431, 2018. (Summary) Studies have reported cases of metal allergy caused by titanium-containing materials. We wished to clarify the relationship between titanium allergy and dental implants by describing patients who suffered allergic symptoms after they had received such implants. A total of 270 patients who visited a Dental Metal Allergy Clinic at Tokushima University Hospital from April 2010 to March 2014 were the study cohort. Patch testing with 28 types of metal allergens (including four titanium allergens) was undertaken for patients. A total of 217 patients (80.4 %) exhibited allergy-positive reactions to at least one type of metal allergen. Mercury, palladium, chromium and nickel exhibited a higher prevalence of allergy-positive reactions than other metals. Sixteen patients visited our clinic suffering allergic symptoms after receiving dental implants. Eleven of those patients exhibited allergy-positive reactions for any of the metal allergens, and 4 of these patients had allergy-positive reactions against titanium allergens. The total number of allergy-positive reactions for titanium allergens among all 270 patients was 17 (6.3 %). No patient exhibited a positive reaction only for the titanium allergen. The prevalence of allergy-positive reactions for titanium allergens was lower than for other metal allergens. We suggest examination of pre-implant patients who have a history of hypersensitivity reactions to metals. (Tokushima University Institutional Repository) ● Metadata: 112948 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jpor.2018.03.003 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29673741 ● Summary page in Scopus @ Elsevier: 2-s2.0-85045460070 (Tokushima University Institutional Repository: 112948, DOI: 10.1016/j.jpor.2018.03.003, PubMed: 29673741, Elsevier: Scopus)
10.	Rika Hayama, Yoshitaka Suzuki, Keisuke Nishigawa, Kazuo Okura, Mayu Miyagi, Susumu Abe and Yoshizo Matsuka : Investigation of behavioural factors which vary occlusal contact in Japanese dental students, The Journal of Japanese Society of Stomatognathic Function, Vol.25, No.1, 1-9, 2018.
11.	Miho Inoue, Mio Naritani, R Raju, Mayu Miyagi, Masamitsu Ohshima, Inoue Masahisa and Yoshizo Matsuka : Effect of short-term Tumour Necrosis Factor-alpha (TNF-α) -stimulation on the growth and differentiation of MC3T3-E1 osteoblast-like cells, Journal of Hard Tissue Biology, Vol.27, No.3, 213-218, 2018. (Tokushima University Institutional Repository) ● Metadata: 113362 (Link to Publication Site) ● Publication site (DOI): 10.2485/jhtb.27.213 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85049948297 (Tokushima University Institutional Repository: 113362, DOI: 10.2485/jhtb.27.213, Elsevier: Scopus)
12.	Junhel Dalanon, LM Diano, MP Belarmino, Rika Hayama, Mayu Miyagi and Yoshizo Matsuka : A Philippine rural schools organizational climate, teachers performance, and management competencies, International Journal of Research -GRANTHAALAYAH, Vol.6, No.1, 248-265, 2018. (Link to Publication Site) ● Publication site (DOI): 10.5281/zenodo.1164303 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.5281/zenodo.1164303 (DOI: 10.5281/zenodo.1164303)
13.	Keisuke Nishigawa, Rika Hayama, Ktsushi Omoto, Kazuo Okura, Toyoko Tajima, Yoshitaka Suzuki, Maki Hosoki, Mayu Miyagi, Miho Inoue, Omar Maningo Rodis and Yoshizo Matsuka : Validity of peer evaluation for team-based learning in a dental school in Japan, Journal of Dental Education, Vol.81, No.12, 1451-1456, 2017. (Summary) The aim of this study was to determine the validity of peer evaluation for team-based learning (TBL) classes in dental education in comparison with the term-end examination records and TBL class scores. Examination and TBL class records of 256 third- and fourth-year dental students in six fixed prosthodontics courses from 2013 to 2015 in one dental school in Japan were investigated. Results of the term-end examination during those courses, individual readiness assurance test (IRAT), group readiness assurance test (GRAT), group assignment projects (GAP), and peer evaluation of group members in TBL classes were collected. Significant positive correlations were found between all combinations of peer evaluation, IRAT, and term-end examination. Individual scores also showed a positive correlation with group score (total of GRAT and GAP). From the investigation of the correlations in the six courses, significant positive correlations between peer evaluation and individual score were found in four of the six courses. In this study, peer evaluation seemed to be a valid index for learning performance in TBL classes. To verify the effectiveness of peer evaluation, all students have to realize the significance of scoring the team member's performance. Clear criteria and detailed instruction for appropriate evaluation are also required. (Keyword) Education, Dental / Educational Measurement / Group Processes / Humans / Japan / Learning / Peer Group / Reproducibility of Results / Schools, Dental / Teaching (Tokushima University Institutional Repository) ● Metadata: 112932 (Link to Publication Site) ● Publication site (DOI): 10.21815/JDE.017.106 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29196333 ● Summary page in Scopus @ Elsevier: 2-s2.0-85038129509 (Tokushima University Institutional Repository: 112932, DOI: 10.21815/JDE.017.106, PubMed: 29196333, Elsevier: Scopus)
14.	Miho Inoue, KAWAHARA Hiroo, Kazuo Okura, Mayu Miyagi, NARITANI Mio, Takuma Iwasa, OMOTO Katsuhiro, Omar Maningo Rodis and Yoshizo Matsuka : Frequency of congenitally missing permanent teeth at a primary dental care clinic in Tokushima, Japan, The Journal of Japan Association of Oral Rehabilitation, Vol.30, No.1, 67-70, 2017. (Keyword) Congenitally missing permanent teeth / hypodontia / primary dental care (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520290884130282880 (CiNii: 1520290884130282880)
15.	Keisuke Nishigawa, K Omoto, Rika Hayama, Gantumur Chimeddulam, Kazuo Okura, Toyoko Tajima, Yoshitaka Suzuki, Maki Hosoki, Shuji Shigemoto, Mayu Miyagi, OMM Rodis and Yoshizo Matsuka : Comparison between flipped classroom and team-based learning in fixed prosthodontic education Journal of Prosthodontic Research, Journal of Prosthodontic Research, Vol.61, No.2, 217-222, 2017. (Tokushima University Institutional Repository) ● Metadata: 111995 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jpor.2016.04.003 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jpor.2016.04.003 (Tokushima University Institutional Repository: 111995, DOI: 10.1016/j.jpor.2016.04.003)
16.	Katsuhiro Omoto, Takuma Iwasa, Shaista Afroz, Mayu Miyagi, Kazuo Okura and Yoshizo Matsuka : Preliminary study of neural excitation with positron emission tomography after tooth mechanical stimulation, The Journal of Japan Association of Oral Rehabilitation, Vol.29, No.1, 28-34, 2016. (Summary) Dentists often cannot objectively find abnormalities in patients who complain of discomfort or abnormal sensation in their dental occlusion. We hypothesized that abnormal neural transmission from the tooth is related to this occlusal discomfort sensation. Chronic tooth contact habits may induce neural excitation from the tooth to the central nervous system, and may aggravate the sensation of discomfort in the central nervous system. However, the details of neural transmission from the tooth to the central nervous system are still unclear. In this study, we stimulated a rat premolar mechanically and observed activated bran sites using positron emission tomography (PET) and 18F-2-fluoro-2-deoxy-D-glucose (FDG). We anesthetized 5-7-week-old male rats using isoflurane inhalation anesthesia and stimulated the upper right premolar mechanically with an electric von Frey system (Model 1601C, IITC Instruments) by measuring mechanical pressure. Before the tooth mechanical stimulation, we injected FDG through the rat's caudal vein and then used a stimulation intensity of 100, 200 or 300 g. We recorded FDG accumulation with PET. The PET brain images were separated into four parts (right higher, left higher, right lower and left lower) for analysis and the peak value of striatal uptake (SUV) in each part was analyzed. The PET images showed that the accumulated FDG in the right lower part of the brain was higher with 300 g tooth stimulation than with 100 or 200 g. The data showed that the tooth stimulation site in the lower part of the brain was activated with tooth stimulation by comparing it with the other parts. We also measured SUV in the right and left sensory areas, motor area, hippocampus, trigeminal ganglia (TG) and spinal cord. The TG and sensory area showed more FDG accumulation compared with mouth opening. (Keyword) Tooth stimulation / neural excitation / positron emission tomography (Tokushima University Institutional Repository) ● Metadata: 113901 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564288893446528 (Tokushima University Institutional Repository: 113901, CiNii: 1050564288893446528)
17.	Kazuo Okura, Yoshitaka Suzuki, Shuji Shigemoto, 大本勝弘, 葉山莉香, 岩浅匠真, 福本美緒, 井上美穂, Mayu Miyagi, Susumu Abe and Yoshizo Matsuka : The effect of splints on sleep bruxism : a preliminary study, The Journal of Japan Association of Oral Rehabilitation, Vol.29, No.1, 21-27, 2016. (Keyword) sleep bruxism / splint / polysomnography (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520572359226098048 (CiNii: 1520572359226098048)
18.	Hisahiro Takeuchi, K Omoto, Kazuo Okura, Toyoko Tajima, Yoshitaka Suzuki, Maki Hosoki, Motoharu Kori, Shuji Shigemoto, Mayu Miyagi, Keisuke Nishigawa, Omar Maningo Rodis and Yoshizo Matsuka : Effects of team-based learning on fixed prosthodontic education in Japan, Journal of Dental Education, Vol.79, No.4, 417-423, 2015. (Summary) The aims of this study were to evaluate the quality of team-based learning (TBL) in prosthodontics education for fourth-year dental students at Tokushima University School of Dentistry and to compare this teaching method with traditional lecture-based delivery. Participants in the study were 36 students (22 males and 14 females) who attended the TBL-style fixed prosthodontics course. Ten 60-minute classes were held. The first three were traditional lecture-style classes and were followed by one class introducing the TBL style. The remaining six classes constituted the TBL-format fixed prosthodontics course. The effectiveness of TBL was evaluated through student questionnaires at the end of each class and the results of the term-end examination. The questionnaire revealed high student approval for TBL-style learning, and active group discussion among students during TBL was a key factor in these ratings. In the results of the term-end examination, there were significantly higher scores on the questions that covered TBL-taught material than those covering traditional lecture-taught topics. The results of this study suggest that TBL-style lecture was more effective than traditional-style lecture for teaching fixed prosthodontics and that TBL was a more efficient mode of delivering dental education than traditional lecture-based teaching. (Keyword) Attitude of Health Personnel / Cooperative Behavior / Education, Dental / Educational Measurement / Feedback / Female / Group Processes / Humans / Japan / Learning / Male / Problem-Based Learning / Prosthodontics / Questionnaires / Students, Dental / Teaching (Tokushima University Institutional Repository) ● Metadata: 111968 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25838013 ● Search Scopus @ Elsevier (PMID): 25838013 (Tokushima University Institutional Repository: 111968, PubMed: 25838013)
19.	大本勝弘, Kazuo Okura, Toyoko Tajima, Yoshitaka Suzuki, Maki Hosoki, Motoharu Kori, Shuji Shigemoto, Mayu Miyagi, Keisuke Nishigawa and Yoshizo Matsuka : Introduction and Effects of Team-Based Learning on Prosthodontic Education, Journal of Oral Health and Biosciences, Vol.27, No.2, 81-87, 2015. (Summary) Team-Based Learning (TBL) was introduced into our prosthodontic education for thirdyear dental school students. Forty students (26 males and 14 females) of Tokushima University School of Dentistry attended the TBL-style fixed prosthodontic course. A total of fifteen classes (60 minutes each), which started with six conventional lecture-style classes followed by 8 TBL-style classes, were held. The effectiveness of TBL was evaluated with student questionnaires at the end of each class and with the results of the term-end examination. The results of the questionnaire on some questions and term-end examination exhibited higher score for the TBL. The results of this study showed that TBL-style classes were more effective than that of the conventional lecture-style classes for the fixed prosthodontic course. (Keyword) チーム基盤型学習 / 固定性義歯学 / 教育効果 (Tokushima University Institutional Repository) ● Metadata: 109857 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050564287418442752 (Tokushima University Institutional Repository: 109857, CiNii: 1050564287418442752)

Review, Commentary:

1.	Mayu Miyagi : Reprogramming of Human Dental Pulp Cells mediated by Inflammatory Signals. Effects of TNF- on Human Dental Pulp Cell Differentiation, Journal of Oral Health and Biosciences, Vol.28, No.1, 1-7, Jun. 2015. (Summary) During normal pulp tissue healing, inflammatory cytokines, such as tumor necrosis factoralpha (TNF-α) or interleukins, act in the initial 48 hours (inflammatory phase) and play important roles not only as chemo-attractants of inflammatory cells and stem/progenitor cells but also in inducing a cascade of reactions toward tissue regeneration or reparative dentin formation or both. Previous reports have shown that inflammatory cytokines regulate the differentiation capacity of dental pulp stem/progenitor cells (DPCs), but none has interrogated the impact of these cytokines on the stem cell phenotype of stem/progenitor cells.In this review, I would like to summarize about the effects of a short-term treatment with TNF-α on the stem cell phenotype and differentiation ability of human DPCs. (Keyword) TNF-α / 幹細胞化 (Tokushima University Institutional Repository) ● Metadata: 109862 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050282812441733248 (Tokushima University Institutional Repository: 109862, CiNii: 1050282812441733248)

Proceeding of International Conference:

1.	H. Miki, H Minakuchi, Mayu Miyagi, Shuji Shigemoto, Yoshitaka Suzuki, K Maekawa, Yoshizo Matsuka and T Kuboki : Validation study of a modified miniature bruxism detection/analyzing device, International Association for Dental Research, Boston, Mar. 2015.
2.	Maki Hosoki, Toyoko Tajima, Keisuke Nishigawa, Mayu Miyagi and Yoshizo Matsuka : Clinical investigation of titanium allergy prevalence, Indonesia Japan Prosthodontic Society Joint Meeting, Bali, Oct. 2014.

Proceeding of Domestic Conference:

1.	Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Masamitsu Ohshima, Mariko Niki, Yoshiaki Kubo and Yoshizo Matsuka : ピアスの金属成分分析と金属アレルギー発症リスクについて, 日本アレルギー学会, Oct. 2024.
2.	横井美有希, 安部倉仁, 森田晃司, 土井一矢, Maki Hosoki, Mayu Miyagi, Miho Inoue, Daisuke Ikutame, 中川晋輔, 秋山謙太郎, 縄稚久美子, 黒崎陽子, Yoshizo Matsuka, 窪木拓男 and 津賀一弘 : 最後方大臼歯へのPEEKクラウンの臨床応用についての6ヶ月間の評価, The Journal of the Japan Prosthodontic Society, Jul. 2024.
3.	Miho Inoue, Masamitsu Ohshima, Mayu Miyagi, Daisuke Ikutame and Yoshizo Matsuka : 口腔顔面痛はアロマテラピーで軽減する∼口腔顔面痛モデル動物での評価∼, The Journal of the Japan Prosthodontic Society, May 2023.
4.	Maki Hosoki, Daisuke Ikutame, Mayu Miyagi, Kazuo Okura, Miho Inoue, OZAWA Aya, SHIBAGAKI Akari, TANIWAKI Tatsuya, Kouhei Kamoi, 伸幸板東, Yasutomo Yoshihara, Masamitsu Ohshima, Yoshitaka Suzuki, SHINKAI Mizuki and Yoshizo Matsuka : デジタル化に対応したクラウンブリッジ補綴学実習の検討, The Journal of the Japan Prosthodontic Society, May 2023.
5.	蓮池真由子, Miho Inoue, RAMAN SWARNA LAKSHMI, Jaime M.Fabillar, Lutfi P.Perdana, Mayu Miyagi, Daisuke Ikutame, Masamitsu Ohshima and Yoshizo Matsuka : 口腔顔面痛モデル動物を用いた精油嗅覚刺激の疼痛抑制効果∼ベルガモット，ラベンダーの検討∼, Shikoku Dental Research, Mar. 2023.
6.	Miho Inoue, RAMAN SWARNA LAKSHMI, FABILLAR JR. JAIME MORENO, 蓮池真由子, PERDANA LUTFI PUTRA, 井上正久, Daisuke Ikutame, Mayu Miyagi, Masamitsu Ohshima and Yoshizo Matsuka : 精油成分による口腔顔面痛モデル動物の痛み軽減とメカニズム, 徳島大学脳科学クラスター・ミニリトリート, Feb. 2023.
7.	Maki Hosoki, Daisuke Ikutame, Mayu Miyagi, Kazuo Okura, Miho Inoue, OZAWA Aya, SHIBAGAKI Akari, TANIWAKI Tatsuya, Kouhei Kamoi, 伸幸板東, C. Riquelme, Yasutomo Yoshihara, Masamitsu Ohshima, Yoshitaka Suzuki, 新開みずき and Yoshizo Matsuka : デジタル化が進む歯科診療の現状紹介と歯科補綴学実習における学習内容の検討, 大学教育カンファレンスin徳島, Dec. 2022.
8.	Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Miho Inoue, Yoshiaki Kubo and Yoshizo Matsuka : 装飾品に対するニッケル表示の標準化をめざした取り組みについて, 日本皮膚免疫アレルギー学会, Dec. 2022.
9.	SHINKAI Mizuki, Yoshitaka Suzuki, Kazuo Okura, 加藤隆史, Mayu Miyagi, SHIBAGAKI Akari, Masamitsu Ohshima and Yoshizo Matsuka : 睡眠時ブラキシズムと睡眠嚥下の関連:系統的レビュー, 日本補綴歯科学会中四国支部学術大会, Aug. 2022.
10.	Toyoko Tajima, Maki Hosoki, Miho Inoue, Aya Ozawa, Mizuki Shinkai, Mayu Miyagi, Mio Naritani, Masamitsu Ohshima, 杉尾隆夫, 山本伊一郎 and Yoshizo Matsuka : 徳島大学病院における歯科用金属アレルギー患者の臨床統計学的検討, The Journal of the Japan Prosthodontic Society, Jul. 2022.
11.	Kazuo Okura, Rika Hayama, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Daisuke Ikutame, Toyoko Tajima, Yasutomo Yoshihara, Aya OZAWA, SHINKAI Mizuki and Yoshizo Matsuka : 歯科補綴学におけるアクティブラーニングの学修効果反転授業とTBL，通常授業の比較, The Journal of the Japan Prosthodontic Society, Jul. 2022.
12.	Maki Hosoki, Yuehui Zhang, Toyoko Tajima, Miho Inoue, 井上正久, Masamitsu Ohshima, Mayu Miyagi and Yoshizo Matsuka : モデルマウスによるチタンアレルギーの検討, Journal of the Japanese Association for Dental Science, Sep. 2021.
13.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Mayu Miyagi, 成谷美緒, Miho Inoue and Yoshizo Matsuka : 金属アレルギー患者群と健常者群における特異的マイクロRNAの同定, The Journal of the Japan Prosthodontic Society, Jun. 2021.
14.	Rika Hayama, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Omar Maningo Rodis, Junhel Dalanon, Raju Resmi and Yoshizo Matsuka : 補綴学授業における反転授業とTBLの学修効果に関する比較, Shikoku Dental Research, Feb. 2021.
15.	Masamitsu Ohshima, Raju Resmi, Miho Inoue, Mayu Miyagi and Yoshizo Matsuka : 骨‐歯根膜線維の複合組織形成による三次元組織再生技術の開発, 公益社団法人日本補綴歯科学会第129回学術大会, Jun. 2020.
16.	Maki Hosoki, Zhang Yuehui, Masamitsu Ohshima, Miho Inoue, Mio Naritani, Mayu Miyagi and Yoshizo Matsuka : 血中マイクロRNAを介した金属アレルギーの感作・発症機序の解明, Journal of the Japanese Association for Dental Science, Vol.39, 58, Mar. 2020.
17.	Rika Hayama, Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Omar Marianito, Takuma Iwasa and Yoshizo Matsuka : 補綴学授業におけるアクティブラーニングによる学修効果-反転授業とTBLの長期比較-, 徳島県歯科医学大会, Feb. 2020.
18.	Maki Hosoki, Miho Inoue, Takuma Iwasa, Yasufumi Nishikawa, 秋月皆人, 吉原靖智, Kazuo Okura, Yuehui Zhang, Huijiao Yan, Waskitho Arief, Ofuchi R.S., Masamitsu Ohshima, Yoshitaka Suzuki, 成谷美緒, Mayu Miyagi, Raju Resmi and Yoshizo Matsuka : 歯科補綴学(Ⅱ)実習における実習書改定後の検討, 大学教育カンファレンスin徳島, Dec. 2019.
19.	Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, Takuma Iwasa and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果―反転授業とTBL，通常授業の比較―, 大学教育カンファレンスin徳島, Dec. 2019.
20.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Mayu Miyagi, 成谷美緒, Miho Inoue and Yoshizo Matsuka : 金属アレルギー患者群と健常者群における特異的マイクロRNAの同定, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2019.
21.	成谷美緒, Maki Hosoki, Mayu Miyagi, Masamitsu Ohshima, Miho Inoue, 岩浅匠真 and Yoshizo Matsuka : 金属アレルギー患者に対する血管内治療の術前評価, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2019.
22.	Maki Hosoki, Yuehui Zhang, Masamitsu Ohshima, Miho Inoue, 成谷美緒, Mayu Miyagi and Yoshizo Matsuka : 血中マイクロRNAを介した金属アレルギーの感作・発症機序の解明, 歯科医学を中心とした総合的な研究を推進する集い, Aug. 2019.
23.	成谷美緒, Maki Hosoki, 池山鎭夫, Mayu Miyagi and Yoshizo Matsuka : コイル塞栓術予定の金属アレルギー患者にコイル成分分析とパッチテストを行った一例, 徳島医学会, Aug. 2019.
24.	Maki Hosoki, Mayu Miyagi, 成谷美緒, Toyoko Tajima, Kazuo Okura, Yoshitaka Suzuki, 後藤奈美, Yasutomo Yoshihara and Yoshizo Matsuka : 10年以上が経過した金属アレルギー患者の口腔内からみえてくるもの, The Journal of the Japan Prosthodontic Society, May 2019.
25.	Maki Hosoki, Miho Inoue, Takuma Iwasa, Yasufumi Nishikawa, 秋月皆人, Yasutomo Yoshihara, Kazuo Okura, Yuehui Zhang, Huijiao Yan, Arief Waskitho, Rodrigo Shigeru Ofuchi, Masamitsu Ohshima, Yoshitaka Suzuki, 成谷美緒, Mayu Miyagi, Raju Resmi and Yoshizo Matsuka : 歯科補綴学(Ⅱ)実習における実習書改定後の検討in徳島, 大学教育カンファレンス, Dec. 2018.
26.	Kazuo Okura, Masamitsu Ohshima, Maki Hosoki, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, 岩浅匠真, Junhel Dalanon and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの学修効果-反転授業とTBLの比較-, 大学教育カンファレンスin徳島, Dec. 2018.
27.	Maki Hosoki, Mayu Miyagi, Miho Inoue, Kazuo Okura, Masamitsu Ohshima, Raju Resmi, 岩浅匠真, 成谷美緒, Zhang Yuehui, Yan Huijiao, Arief Waskitho, Junhel Dalanon, Yoshitaka Suzuki, 吉原靖智 and Yoshizo Matsuka : 歯科補綴学実習における実習書の改訂とその効果の検討, 大学教育カンファレンスin徳島, Dec. 2018.
28.	Yuehui Zhang, Maki Hosoki, Masamitsu Ohshima, Mayu Miyagi, Mio Naritani and Yoshizo Matsuka : 金属アレルギーに関する特異的遺伝子の検討, 日本補綴歯科学会関西支部学術大会, Dec. 2018.
29.	Miho Inoue, Mio Naritani, R. Raju, Mayu Miyagi and Yoshizo Matsuka : 腫瘍壊死因子TNF-αによる歯髄細胞，骨髄細胞の幹細胞化, 徳島大学大学院医歯薬学研究部発生・再生・遺伝クラスター・ミニリトリート, Mar. 2017.
30.	Yoshizo Matsuka, Takuma Iwasa, S. Afroz, Katsuhiro Ohmoto, Miho Inoue, Mio Naritani, Mayu Miyagi and Kazuo Okura : 末梢知覚神経節における神経伝達物質による痛み情報伝達, 徳島大学医歯薬学研究部脳科学クラスター・ミニリトリート, Mar. 2017.
31.	Kazuo Okura, Keisuke Nishigawa, Maki Hosoki, Toyoko Tajima, Yoshitaka Suzuki, Mayu Miyagi, Miho Inoue, 大本勝弘, 葉山莉香 and Yoshizo Matsuka : 歯科補綴学授業におけるアクティブラーニングの効果 ―反転授業とTBLの比較―, 大学教育再生加速プログラムシンポジウム, Dec. 2016.
32.	Maki Hosoki, Toyoko Tajima, Mayu Miyagi, Keisuke Nishigawa, 成谷美緒 and Yoshizo Matsuka : 歯科用金属アレルギー患者の動向, Journal of the Japanese Association for Dental Science, Oct. 2016.
33.	友竹偉側, Toyoko Tajima, Yoshihito Naitou, Yuichi Ishida, Mayu Miyagi, Susumu Abe, Yoshizo Matsuka and Tetsuo Ichikawa : インプラント治療前後の口腔関連QOLの評価:形態的困難度の影響, Journal of Japanese Society of Oral Implantology, Sep. 2016.
34.	Kazuo Okura, 岩浅匠真, Shuji Shigemoto, Kouhei Kamoi, Mayu Miyagi, 藤本隆広, 山本伊一郎 and Yoshizo Matsuka : ARCTICA固定用アダプター使用によるCAD/CAMスキャンニングの検討, 日本補綴歯科学会九州,中国・四国支部学術大会, Sep. 2016.
35.	Susumu Abe, 堀川恵理子, Eiji Tanaka, Fumihiro Matsumoto, 大本勝弘, 葉山莉香, Mayu Miyagi, Kazuo Okura and Yoshizo Matsuka : 徳島大学病院顎関節症外来に来院した顎関節症患者の臨床統計学的調査, Journal of the Japanese Society for the Temporomandibular Joint, Jul. 2016.
36.	葉山莉香, Mayu Miyagi, 菊谷武 and Yoshizo Matsuka : 経口摂取が可能となり，胃瘻から脱却した一症例, 日本老年歯科医学会, Jun. 2016.
37.	Mayu Miyagi, Miho Inoue, 福本美緒 and Yoshizo Matsuka : 炎症環境による歯髄細胞の幹細胞化―歯髄細胞分化に与える TNF-αの影響―, The Journal of Japanese Society of Stomatognathic Function, Apr. 2016.
38.	Yoshizo Matsuka, 大本勝弘, 岩浅匠真, Miho Inoue, 福本美緒, Mayu Miyagi and Kazuo Okura : 知覚神経節における神経伝達物質による痛み情報伝達の可能性, The Journal of Japanese Society of Stomatognathic Function, Apr. 2016.
39.	Keisuke Nishigawa, Kazuo Okura, Maki Hosoki, Shuji Shigemoto, Mayu Miyagi, Toyoko Tajima, Takaho Shigemoto, Yoshitaka Suzuki, 大本勝弘, 葉山莉香 and Yoshizo Matsuka : 冠橋義歯学授業において行った反転授業とTBL授業の比較, 大学教育カンファレンスin徳島, Jan. 2016.
40.	Miki Haruna, Minakuchi Hajime, Mayu Miyagi, Shuji Shigemoto, Maekawa Kenji, Yoshizo Matsuka and Kuboki Takuo : Sleep arousal-related comorbid motor activities recorded concomitantly with sleep bruxism, Japanese Association for Dental Research, Oct. 2015.
41.	福本美緒, Maki Hosoki, 井上美穂, Keisuke Nishigawa, Toyoko Tajima, Takaho Shigemoto, Mayu Miyagi, 清水さとみ, 福田政司, 安村博 and Yoshizo Matsuka : ニッケルアレルギーモデルマウスの感作特性の検討, 日本補綴歯科学会中国・四国支部学術大会, Sep. 2015.
42.	Susumu Abe, Fumihiro Matsumoto, Eiji Tanaka, 大本勝弘, 葉山莉香, Mayu Miyagi, Kazuo Okura and Yoshizo Matsuka : 顎関節症外来患者におけるアンケートを用いた睡眠の質の実態調査, 日本顎関節学会・日本口腔顔面痛学会, Jul. 2015.
43.	Maki Hosoki, Keisuke Nishigawa, 大本勝弘, Mayu Miyagi, Toyoko Tajima and Yoshizo Matsuka : ニッケルアレルギーモデルマウスの作製と炎症局所のサイトカイン活性について, The Journal of the Japan Prosthodontic Society, May 2015.
44.	三木春奈, 水口一, Mayu Miyagi, Shuji Shigemoto, Yoshitaka Suzuki, 前川賢治, Yoshizo Matsuka and 窪木拓男 : 健常者における睡眠時の覚醒反応と随伴運動との関連, The Journal of the Japan Prosthodontic Society, May 2015.
45.	Kazuo Okura, 大本勝弘, Toyoko Tajima, Yoshitaka Suzuki, Maki Hosoki, Motoharu Kori, Shuji Shigemoto, Mayu Miyagi, Keisuke Nishigawa, 葉山莉香, Chimeddulam G. and Yoshizo Matsuka : 歯科補綴授業におけるチーム基盤型学習の効果, Shikoku Dental Research, Mar. 2015.
46.	Toyoko Tajima, 大本勝弘, Kazuo Okura, Yoshitaka Suzuki, Maki Hosoki, Motoharu Kori, Shuji Shigemoto, Mayu Miyagi, Keisuke Nishigawa and Yoshizo Matsuka : 歯科補綴学授業へのチーム基盤型学習法(TBL)の導入とその効果, 大学教育カンファレンス in 徳島, Dec. 2014.
47.	Keisuke Nishigawa, Kazuo Okura, Maki Hosoki, Motoharu Kori, Toyoko Tajima, Yoshitaka Suzuki, Mayu Miyagi and Yoshizo Matsuka : 歯科臨床教育への反転授業の導入, 大学教育カンファレンス in 徳島, Dec. 2014.
48.	三木春奈, 水口一, Mayu Miyagi, Shuji Shigemoto, Yoshitaka Suzuki, 前川賢治, Yoshizo Matsuka and 窪木拓男 : 簡易貼付型睡眠時ブラキシズム測定装置の測定精度の検討, 日本補綴歯科学会中国・四国,関西支部合同学術大会, Sep. 2014.
49.	三浦茉里子, Keisuke Nishigawa, Yoshitaka Suzuki, 大本勝弘, 藤枝創, Mayu Miyagi, 葉山莉香, Maki Hosoki and Yoshizo Matsuka : 咬合接触面積に及ぼすブラキシズムの影響について, 日本補綴歯科学会中国・四国,関西支部合同学術大会, Sep. 2014.
50.	Mayu Miyagi, 藤澤拓生, 大野光昭, E.S. Hara, P.T. Hai, 園山亘, 窪木拓男 and Yoshizo Matsuka : 炎症環境による歯髄細胞の幹細胞化-歯髄細胞分化に与えるTNF-αの影響-, 日本再生歯科医学会, Aug. 2014.
51.	三木春奈, 水口一, Mayu Miyagi, Shuji Shigemoto, Yoshitaka Suzuki, 前川賢治, Yoshizo Matsuka and 窪木拓男 : 簡易貼付型睡眠時ブラキシズム測定装置の測定制度の検討, Journal of the Japanese Society for the Temporomandibular Joint, Jul. 2014.
52.	大本勝弘, Shuji Shigemoto, 後藤奈美, Yoshitaka Suzuki, Mayu Miyagi, 髙橋陽光 and Yoshizo Matsuka : 連続 24 時間筋電図記録による覚醒時と睡眠時の咬筋活動の比較, The Journal of the Japan Prosthodontic Society, May 2014.
53.	Toyoko Tajima, Hisahiro Takeuchi, Keisuke Nishigawa, Kazuo Okura, 大本勝弘, Yoshitaka Suzuki, Maki Hosoki, Motoharu Kori, Shuji Shigemoto, Mayu Miyagi and Yoshizo Matsuka : 冠橋義歯学授業へのチーム基盤型学習法の導入とその効果, The Journal of the Japan Prosthodontic Society, May 2014.

Et cetera, Workshop:

1.	Resmi Raju, Miho Inoue, M. Naritani, Mayu Miyagi, Yuehui Zhang, Masamitsu Oshima, Masahisa Inoue and Yoshizo Matsuka : Cellular kinetics of bone marrow derived mesenchymal cells by short-term TNF-alpha stimulation, Tokushima University Bioscience Retreat, Sep. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Investigation of mechanism for anti DKK-1 antibody possessing bone formation (Project/Area Number: 17K11753 )
Development of a novel therapy based on stem cell conversion of dental pulp cells (Project/Area Number: 16K11600 )
Metal allergy; What is the difference between sensitization and onset? -Identification of specific genes- (Project/Area Number: 16K11599 )
Development of new dental pulp capping material applied effect of reprograming of dental pulp cells by TNF-alpha (Project/Area Number: 26861640 )
Investigation of titanium allergy, elucidation and prevention methods (Project/Area Number: 25463003 )
Elucidation of the mechanism of dentin regeneration focused on reprogramming of human dental pulp cells mediated by TNF-alpha (Project/Area Number: 24792084 )
Search by Researcher Number (20625719)

Assistant Professor : Miyagi, Mayu

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)