Tokushima University / Educator and Researcher Directory --- Matsumoto, Takeshi

Personal Web Page

https://researchmap.jp/physiol_engineering (researchmap)

https://orcid.org/0000-0003-4799-7963 (ORCID)

Field of Study

○	Biomedical Engineering

Subject of Study

○	Biomedical engineering approach to understanding bone/microcirculation-related disorders

Book / Paper

Book:

1.	Ji-Yean Kwon, Hisashi Naito, Takeshi Matsumoto and Masao Tanaka : Apoptosis and medicine (Ntuli TM ed), --- Osteocyte Apoptosis-Induced Bone Resorption in Mechanical Remodeling Simulation - Computational Model for Trabecular Bone Structure ---, InTech, 2012.
2.	Masao Tanaka, Takeshi Matsumoto and Masahiro Todoh : Biomechanics at Micro- and Nanoscale IV (Wada H ed), --- Microscopic Analysis of Bone ---, World Scientific, 2007.
3.	Takeshi Matsumoto, Masayuki Yoshino and Masao Tanaka : Biomechanics at Micro- and Nanoscale Levels II (Wada H ed), --- Assessment of Cortical Bone Microstructure Using Monochromatic Synchrotron Radiation Micro-CT ---, World Scientific, 2006.
4.	Masao Tanaka, Takeshi Matsumoto, Masumi Ihara and Masahiro Todoh : Biomechanics at Micro- and Nanoscale Levels I (Wada H ed), --- Note on Anisotropic Properties of Cancellous Bone and Trabeculae: Elasticity and Hardness ---, World Scientific, 2005.
5.	Takeshi Matsumoto and 望月精一 : 化学工学 (酒井清孝編), --- 第2章流れ ---, 朝倉書店, Sep. 2005.
6.	Takeshi Matsumoto : 冠循環のバイオメカニクス (梶谷文彦編), --- 第4章3節冠血流分布の不均一性 ---, コロナ社, 2001.

Academic Paper (Judged Full Paper):

1.	Takeshi Matsumoto, Keishi Hashimoto and Hyuga Okada : Discretizing Low-Intensity Whole-Body Vibration Into Bouts With Short Rest Intervals Promotes Bone Defect Repair in Osteoporotic Mice, Journal of Orthopaedic Research, Vol.2024, 1-9, 2024. (Summary) Continuous administration of low-intensity whole-body vibration (WBV) gradually diminishes bone mechanosensitivity over time, leading to a weakening of its osteogenic effect. We investigated whether discretizing WBV into bouts with short rest intervals was effective in enhancing osteoporotic bone repair. Ten-week-old female mice were ovariectomized and underwent drill-hole defect surgery (Day 0) on the right tibial diaphysis at 11 weeks of age. The mice underwent one of three regimens starting from Day 1 for 5 days/week: continuous WBV at 45 Hz and 0.3 g for 7.5 min/day (cWBV); 3-s bouts of WBV at 45 Hz, 0.3 g followed by 9-s rest intervals, repeated for 30 min/day (repeated bouts of whole-body vibration with short rest intervals [rWBV]); or a sham treatment. Both the cWBV and rWBV groups received a total of 20,250 vibration cycles per day. On either Day 7 or 14 posteuthanasia (n = 6/group/timepoint), the bone and angiogenic vasculature in the defect were computed tomography imaged using synchrotron light. By Day 14, the bone repair was most advanced in the rWBV group, showing a higher bone volume fraction and a more uniform mineral distribution compared with the sham group. The cWBV group exhibited an intermediate level of bone repair between the sham and rWBV groups. The rWBV group had a decrease in large-sized angiogenic vessels, while the cWBV group showed an increase in such vessels. In conclusion, osteoporotic bone repair was enhanced by WBV bouts with short rest intervals, which may potentially be attributed to the improved mechanosensitivity of osteogenic cells and alterations in angiogenic vasculature. (Tokushima University Institutional Repository) ● Metadata: 118967 (Link to Publication Site) ● Publication site (DOI): 10.1002/jor.25781 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/jor.25781 (Tokushima University Institutional Repository: 118967, DOI: 10.1002/jor.25781)
2.	Shusaku Kawano, Takako Yagi, Masato Hoshino and Takeshi Matsumoto : In-Situ Deformation Imaging of Articular Cartilage Using Grating-Based Phase-Contrast X-ray CT at a Synchrotron Light Source, Journal of Biorheology, Vol.36, No.2, 51-57, 2022. (Summary) Quantification of deformation behavior of articular cartilage (AC) is crucial for understanding its mechanical function and response to mechanical stimuli. Here, we explored whether grating-based phase-contrast X-ray CT using monochromatic synchrotron light (grating-based msPXCT) enables in-situ quantification of local deformation in AC. Grating-based msPXCT of a porcine AC sample during axial compression test was conducted using a Talbotgrating interferometer. Local displacements and strains were computed using a digital volume correlation method. The magnitude of axial strain decreased from the upper to middle sample zones and reached almost constant over the middle-lower zone, consistent with the depth-dependent density increase with compression. Thus, grating-based msPXCT may be suitable for quantitative analysis of AC deformation. (Keyword) articular cartilage / high density resolution / compression / digital volume correlation / strain (Link to Publication Site) ● Publication site (DOI): 10.17106/jbr.36.51 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390856815742391296 ● Search Scopus @ Elsevier (DOI): 10.17106/jbr.36.51 (DOI: 10.17106/jbr.36.51, CiNii: 1390856815742391296)
3.	Takeshi Matsumoto and Akihiro Mukohara : Effects of Whole-Body Vibration on Breast Cancer Bone Metastasis and Vascularization in Mice, Calcified Tissue International, Vol.111, No.5, 535-545, 2022. (Summary) We evaluated whether whole-body vibration (WBV) prevented bone loss induced by breast cancer (BC) metastasis and the involvement of bone marrow vasculature. One day after orthotopic transplantation of mammary 4T1 tumor cells, 8-week-old BALB/c mice were subjected to 0.3 g/90 Hz vertical vibration for 20 min/day for 5 days/week (BC-WBV) or sham-handled (BC-Sham) over 3 weeks. Age-matched intact mice (Intact) were also sham-handled. Both tibiae were harvested from BC-WBV (n=7), BC-Sham (n=9), and Intact (n=5) mice for bone structure imaging by synchrotron radiation-based computed tomography (SRCT) and hematoxylin and eosin staining, whereas right tibiae were harvested from other BC-WBV and BC-Sham (n=6 each) mice for vascular imaging by SRCT. Tumor cells were similarly widespread in the marrow in BC-WBV and BC-Sham mice. In BC-Sham mice, cortical bone volume, trabecular volume fraction, trabecular thickness, trabecular number density, and bone mineral density were smaller, and marrow volume and trabecular separation were larger than in Intact mice. However, although trabecular thickness was smaller in BC-WBV than Intact mice, the others did not differ between the two groups. Serum osteocalcin tended to be higher in BC-WBV than BC-Sham mice. Compared with BC-Sham mice, BC-WBV mice had a smaller vessel diameter, a trend of a larger vessel number density, and smaller vessel diameter heterogeneity. In conclusion, WBV mitigates bone loss in BC bone metastasis, which may be partly due to increased bone anabolism. The alteration of marrow vasculature appears to be favorable for anti-tumor drug delivery. Further studies are needed to clarify the multiple actions of WBV on bone, tumor, and marrow vasculature and how they contribute to bone protection in BC metastasis. (Tokushima University Institutional Repository) ● Metadata: 118033 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00223-022-01009-4 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1007/s00223-022-01009-4 (Tokushima University Institutional Repository: 118033, DOI: 10.1007/s00223-022-01009-4)
4.	Takeshi Matsumoto, Ryota Shimizu and Kentaro Uesugi : In Vivo Monitoring of Bone Microstructure by Propagation-Based Phase-Contrast Computed Tomography Using Monochromatic Synchrotron Light, Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.100, No.1, 72-83, 2020. (Summary) Hard X-ray phase-contrast imaging is sensitive to density variation in objects and shows a dose advantage for in vivo observation over absorption-contrast imaging. We examined the capability of propagation-based phase-contrast tomography (PB-PCT) with single-distance phase retrieval for tracking of bone structure and mineral changes using monochromatic synchrotron light. Female mice underwent ovariectomy and drill-hole surgery in the right tibial diaphysis and were divided into two groups: OVX and OVX-E (n = 6 each); the latter group was treated with intraperitoneal administration of 14,15-epoxyeicosatrienoic acid (14,15-EET) for promoting bone repair. Age-matched mice subjected to sham ovariectomy and drill-hole surgery (Sham) were also prepared (n = 6). In vivo CT scans of the drilled defect were acquired 3, 7, and 11 days after surgery, and tomographic images were matched by three-dimensional registration between successive time points for monitoring the process of defect filling. In addition, using absorption-contrast CT as the reference method, the validity of PB-PCT was evaluated in one mouse by comparing images of tibial metaphyseal bone between the two methods in terms of bone geometry as well as the measure of mineralization. Although phase retrieval is strictly valid only for single-material objects, PB-PCT, with its lower radiation dose, could provide a depiction of bone structure similar to that from absorption-contrast CT. There was a significant correlation of linear absorption coefficients between the two methods, indicating the possibility of a rough estimate of the measure of mineralization by PB-PCT. Indeed, delayed bone regeneration (OVX vs. Sham) and the efficacy of 14,15-EET for improving osteoporotic bone repair (OVX-E vs. OVX) could be detected in both bone volume and mineralization by PB-PCT. Thus, in combination with single-distance phase retrieval, PB-PCT would have great potential for providing a valuable tool to track changes in bone structure and mineralization, and for evaluating the effects of therapeutic interventions as well. (Tokushima University Institutional Repository) ● Metadata: 113991 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41374-019-0337-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31641229 ● Search Scopus @ Elsevier (PMID): 31641229 ● Search Scopus @ Elsevier (DOI): 10.1038/s41374-019-0337-3 (Tokushima University Institutional Repository: 113991, DOI: 10.1038/s41374-019-0337-3, PubMed: 31641229)
5.	Toshihiro Sera, Hiroaki Kobayashi, Masato Hoshino, Kentaro Uesugi, Takeshi Matsumoto and Masao Tanaka : The Disuse Effect on Canal Network Structure and Oxygen Supply in the Cortical Bones of Rats, Biomechanics and Modeling in Mechanobiology, Vol.18, No.2, 375-385, 2018. (Summary) In this study, based on the measurements of intracortical vascular canal structure, we investigated the disuse effect on local O supply in the cortical bones of growing rats. Hindlimb disuse was produced by unilateral sciatic neurectomy (SN) at 4 weeks age. The canal network structures within tibial cortical bone were evaluated in 8- and 12-week-old rats undergoing SN or no treatment (control) by synchrotron radiation micro-CT. Additionally, we developed an intracortical network model by combining the imaged-based canal network with a bone matrix containing theoretical lacunar-canalicular network, and determined the distribution of O concentration in bone tissue numerically. In the control bone, canal network was reduced with growth, resulting in decreased blood flow and averaged O concentration and increased spatial heterogeneity in tissue O concentration. Disuse reduced the canal network, leading to a lower flow rate, lower average O concentration and higher heterogeneity of O concentrations. However, the rarefaction of the canal network with growth was smaller under the disuse condition, and accordingly, the flow rate, the average O concentration and the heterogeneity of O concentrations remained stable. In particular, although the fraction of the canal volume was smaller, the densities of canal segments and bifurcation points under disuse condition tended to be higher than those of the control bone. The heterogeneity of O concentration was lower. Our results indicated that the disuse may lead to more uniformity in the canal network structure and thereby uniform O, possibly contributing to O supply efficiency. (Link to Publication Site) ● Publication site (DOI): 10.1007/s10237-018-1088-6 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30386958 ● Summary page in Scopus @ Elsevier: 2-s2.0-85055991479 (DOI: 10.1007/s10237-018-1088-6, PubMed: 30386958, Elsevier: Scopus)
6.	Toshihiro Sera, Yuya Iwai, Takaharu Yamazaki, Tetsuya Tomita, Hideki Yoshikawa, Hisashi Naito, Takeshi Matsumoto and Masao Tanaka : Strain Measurements of the Tibial Insert of a Knee Prosthesis Using a Knee Motion Simulator, Journal of Orthopaedics, Vol.14, No.4, 495-500, 2017. (Summary) The longevity of a knee prosthesis is influenced by the wear of the tibial insert due to its posture and movement. In this study, we assumed that the strain on the tibial insert is one of the main reasons for its wear and investigated the influence of the knee varus-valgus angles on the mechanical stress of the tibial insert. Knee prosthesis motion was simulated using a knee motion simulator based on a parallel-link six degrees-of-freedom actuator and the principal strain and pressure distribution of the tibial insert were measured. In particular, the early stance phase obtained from in vivo X-ray images was examined because the knee is applied to the largest load during extension/flexion movement. The knee varus-valgus angles were 0° (neutral alignment), 3°, and 5° malalignment. Under a neutral orientation, the pressure was higher at the middle and posterior condyles. The first and second principal strains were larger at the high and low pressure areas, respectively. Even for a 3° malalignment, the load was concentrated at one condyle and the positive first principal strain increased dramatically at the high pressure area. The negative second principal strain was large at the low pressure area on the other condyle. The maximum equivalent strain was 1.3-2.1 times larger at the high pressure area. For a 5° malalignment, the maximum equivalent strain increased slightly. These strain and pressure measurements can provide the mechanical stress of the tibial insert in detail for determining the longevity of an artificial knee joint. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jor.2017.08.003 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28839353 ● Search Scopus @ Elsevier (PMID): 28839353 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jor.2017.08.003 (DOI: 10.1016/j.jor.2017.08.003, PubMed: 28839353)
7.	Takeshi Matsumoto and Daichi Goto : Effect of Low-Intensity Whole-Body Vibration on Bone Defect Repair and Associated Vascularization in Mice, Medical and Biological Engineering and Computing, Vol.55, 2257-2266, 2017. (Tokushima University Institutional Repository) ● Metadata: 113989 (Link to Publication Site) ● Publication site (DOI): 10.1007/s11517-017-1664-4 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1007/s11517-017-1664-4 (Tokushima University Institutional Repository: 113989, DOI: 10.1007/s11517-017-1664-4)
8.	Ryosuke Higashi, Toshihiro Sera, Hisashi Naito, Takeshi Matsumoto and Masao Tanaka : Pulmonary Kinematic Analysis With Non-Rigid Deformable Registration for Detecting Localised Emphysema, Computer Methods in Biomechanics and Biomedical Engineering. Imaging & Visualization, Vol.5, No.2, 100-109, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1080/21681163.2015.1008649 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1080/21681163.2015.1008649 (DOI: 10.1080/21681163.2015.1008649)
9.	Toshihiro Sera, Ryosuke Higashi, Hisashi Naito, Takeshi Matsumoto and Masao Tanaka : Distribution of Nanoparticle Depositions after a Single Breathing in a Murine Pulmonary Acinus Model, International Journal of Heat and Mass Transfer, Vol.108, No.Part A, 730-739, 2017. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ijheatmasstransfer.2016.12.057 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijheatmasstransfer.2016.12.057 (DOI: 10.1016/j.ijheatmasstransfer.2016.12.057)
10.	Takeshi Matsumoto, Shinya Itamochi and Yoshihiro Hashimoto : Effect of Concurrent Use of Whole-Body Vibration and Parathyroid Hormone on Bone Structure and Material Properties of Ovariectomized Mice, Calcified Tissue International, Vol.98, No.5, 520-529, 2016. (Summary) This study was designed to determine the effectiveness of whole-body vibration (WBV) and intermittent parathyroid hormone (iPTH) in combination against estrogen deficiency-induced osteoporosis. Female C57BL/6J mice were bilaterally ovariectomized (OVX, n = 40) or sham-operated (sham-OVX, n = 8) at 9 weeks of age. Two weeks later, the OVX mice were randomly divided into four groups (n = 10 each): the control group (c-OVX) and groups treated with iPTH (p-OVX), WBV (w-OVX) and both (pw-OVX). The p-OVX and pw-OVX groups were given human PTH (1-34) at a dose of 30 µg/kg/day. The w-OVX and pw-OVX groups were exposed to WBV at an acceleration of 0.3 g and 45 Hz for 20 min/day. All mice were euthanized after the 18-day treatment, and the left tibiae were harvested. The proximal metaphyseal region was µCT-scanned, and its cortical bone cross-section was analyzed by Fourier transform infrared microspectroscopy and nanoindentation testing. A single application of iPTH or WBV to OVX mice had no effect on bone structure or material properties of cortical bone, which were compromised in comparison to those in sham-OVX mice. The combination of iPTH and WBV improved trabecular bone volume, thickness, and connectivity in OVX mice. Although the combined treatment failed to improve cortical bone structure, its mineral maturity and hardness were restored to the levels observed in sham-OVX mice. There was no evidence of interaction between the two treatments, and the combined effects seemed to be additive. These results suggest combining WBV with iPTH has great potential for treating postmenopausal osteoporosis. (Tokushima University Institutional Repository) ● Metadata: 113990 (Link to Publication Site) ● Publication site (DOI): 10.1007/s00223-015-0104-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26746476 ● Search Scopus @ Elsevier (PMID): 26746476 ● Search Scopus @ Elsevier (DOI): 10.1007/s00223-015-0104-4 (Tokushima University Institutional Repository: 113990, DOI: 10.1007/s00223-015-0104-4, PubMed: 26746476)
11.	Takeshi Matsumoto, Daisuke Sato and Yoshihiro Hashimoto : Individual and Combined Effects of Noise-Like Whole Body Vibration and Parathyroid Hormone Treatment on Bone Defect Repair in Ovariectomized Mice, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, Vol.230, No.1, 30-38, 2015. (Summary) The effectiveness of intermittent administration of parathyroid hormone and exposure to whole-body vibration on osteoporotic fracture healing has been previously investigated, but data on their concurrent use are lacking. Thus, we evaluated the effects of intermittent administration of parathyroid hormone, whole-body vibration, and their combination on bone repair in osteoporotic mice. Noise-like whole-body vibration with a broad frequency range was used instead of conventional sine-wave whole-body vibration at a specific frequency. Mice were ovariectomized at 9 weeks of age and subjected to drill-hole surgery in the right tibial diaphysis at 11 weeks. The animals were divided into four groups (n = 12 each): a control group, and groups treated with intermittent administration of parathyroid hormone, noise-like whole-body vibration, and both. From postoperative day 2, the groups treated with intermittent administration of parathyroid hormone and groups treated with both intermittent administration of parathyroid hormone and noise-like whole-body vibration were subcutaneously administered parathyroid hormone at a dose of 30 µg/kg/day. The groups treated with noise-like whole-body vibration and groups treated with both intermittent administration of parathyroid hormone and noise-like whole-body vibration were exposed to noise-like whole-body vibration at a root mean squared acceleration of 0.3g and frequency components of 45-100 Hz for 20 min/day. Following 18 days of interventions, the right tibiae were harvested, and the regenerated bone was analyzed by micro-computed tomography and nanoindentation testing. Compared with the control group, callus volume fraction was 40% higher in groups treated with intermittent administration of parathyroid hormone and 73% higher in groups treated with both intermittent administration of parathyroid hormone and noise-like whole-body vibration, and callus thickness was 35% wider in groups treated with both intermittent administration of parathyroid hormone and noise-like whole-body vibration. Indentation modulus was 46% higher in groups treated with noise-like whole-body vibration and 43% higher in groups treated with both intermittent administration of parathyroid hormone and noise-like whole-body vibration, and hardness was 31% higher in groups treated with both intermittent administration of parathyroid hormone and noise-like whole-body vibration compared with the control group. There was no interaction between the two treatments for both structure and mechanical indexes. The main effects of intermittent administration of parathyroid hormone and noise-like whole-body vibration on bone repair included increased bone formation and enhanced mechanical function of regenerated bone, respectively. The combined treatment resulted in further regeneration of bone with high indentation modulus and hardness, suggesting the therapeutic potential of the combined use of noise-like whole-body vibration and intermittent administration of parathyroid hormone for enhancing osteoporotic bone healing. (Tokushima University Institutional Repository) ● Metadata: 114013 (Link to Publication Site) ● Publication site (DOI): 10.1177/0954411915616987 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26586525 ● Summary page in Scopus @ Elsevier: 2-s2.0-84952932769 (Tokushima University Institutional Repository: 114013, DOI: 10.1177/0954411915616987, PubMed: 26586525, Elsevier: Scopus)
12.	橋本佳洋 and Takeshi Matsumoto : 再生骨の骨質および力学特性に対する全身性微振動および断続的副甲状腺ホルモン(1-34)投与の相乗的作用の解析, SPring-8/SACLA利用研究成果集, Vol.3, No.2, 380-384, 2015. (Link to Publication Site) ● Publication site (DOI): 10.18957/rr.3.2.380 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390849931329260032 ● Search Scopus @ Elsevier (DOI): 10.18957/rr.3.2.380 (DOI: 10.18957/rr.3.2.380, CiNii: 1390849931329260032)
13.	Takeshi Matsumoto and Shota Sato : Stimulating Angiogenesis Mitigates the Unloading-Induced Reduction in Osteogenesis in Early-Stage Bone Repair in Rats, Physiological Reports, Vol.3, No.3, e12335-1-e12335-12, 2015. (Summary) Accelerating fracture healing during bed rest allows early mobilization and avoids prolonged fracture healing times. We tested the hypothesis that stimulating angiogenesis with deferoxamine (DFO) mitigates the unloading-induced reduction in early-stage bone repair. Rats aged 12 weeks were subjected to cortical drilling on their tibial diaphysis under anesthesia and treated with hindlimb unloading (HU), HU and DFO administration (DFOHU), or weight bearing (WB) for 5 or 10 days (HU5/10, DFOHU5/10, WB5/10; n = 8 per groups) until sacrifice for vascular casting with a zirconium dioxide-based contrast agent. Taking advantage of its absorption discontinuity at the K-absorption edge, vascular and bone images in the drill-hole defects were acquired by synchrotron radiation subtraction CT. Bone repair was reduced in HU rats. The bone volume fraction (B.Vf) was 88% smaller in HU5 and 42% smaller in HU10 than in WB5/10. The bone segment densities (B.Seg) were 97% smaller in HU5 and 141% larger in HU10 than in WB5/10, and bone thickness (B.Th) was 38% smaller in HU10 than in WB10. The vascular volume fraction (V.Vf) was 35% and the mean vessel diameter (V.D) was 13% smaller in HU10 than in WB10. When compared according to categorized vessel sizes, V.Vf in the diameter ranges 20-30, 30-40, and >40 m were smaller in HU10 than in WB10, and V.Seg in the diameter range >40 m was smaller in HU10 than in WB10. In contrast, there was no difference in B.Vf between DFOHU5/10 and WB5/10 and in V.Vf between DFOHU10 and WB10, though B.Seg remained 86% smaller in DFOHU5 and 94% larger in DFOHU10 than in WB5/10, and B.Th and V.D were 23% and 14% lower in DFOHU10 than in WB10. Vessel size-specific V.Vf in the diameter ranges 10-20 and 20-30 m was larger in DFOHU5 than in HU5. In conclusion, the enhanced angiogenic ingrowth mitigates the reduction in bone repair during mechanical unloading. (Link to Publication Site) ● Publication site (DOI): 10.14814/phy2.12335 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25780087 ● Search Scopus @ Elsevier (PMID): 25780087 ● Search Scopus @ Elsevier (DOI): 10.14814/phy2.12335 (DOI: 10.14814/phy2.12335, PubMed: 25780087)
14.	Yoshihiro Hashimoto, Shuichiro Fukushima, Takeshi Matsumoto, Hisashi Naito and Masao Tanaka : Second Harmonic Generation Microscopy and Synchrotron Radiation CT for the Determination of Collagen and Mineral Deposition in Early-Stage Bone Repair: Effect of Whole Body Micro-Vibration, Advanced Biomedical Engineering, Vol.3, 101-105, 2014. (Link to Publication Site) ● Publication site (DOI): 10.14326/abe.3.101 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.14326/abe.3.101 (DOI: 10.14326/abe.3.101)
15.	Takeshi Matsumoto, Daichi Goto and Shota Sato : Subtraction Micro-Computed Tomography of Angiogenesis and Osteogenesis During Bone Repair Using Synchrotron Radiation With a Novel Contrast Agent, Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.93, No.9, 1054-1063, 2013. (Summary) Quantitative three-dimensional (3D) imaging of angiogenesis during bone repair remains an experimental challenge. We developed a novel contrast agent containing 0.07- to 0.1-μm particles of zirconium dioxide (ZrCA) and established subtraction μCT using synchrotron radiation (sSRCT) for quantitative imaging of angiogenesis and bone repair. This method was applied to a rat model of tibial bone repair 3 days (DAY3; n = 2), 5 days (DAY5; n = 8), or 10 days (DAY10; n = 8) after drill-hole injury. Using the same drill-hole defect model, its potential use was illustrated by comparison of bone repair between hindlimbs subjected to mechanical unloading (n = 6) and normal weight bearing (n = 6) for 10 days. Following vascular casting with ZrCA, the defect site was scanned with 17.9- and 18.1-keV X-rays. In the latter, image contrast between ZrCA-filled vasculature and bone was enhanced owing to the sharp absorption jump of zirconium dioxide at 18.0 keV (k-edge). The two scan data sets were reconstructed with 2.74-μm voxel resolution, registered by mutual information, and digitally subtracted to extract the contrast-enhanced vascular image. K2HPO4 phantom solutions were scanned at 17.9 keV for quantitative evaluation of bone mineral. Angiogenesis had already started, but new bone formation was not found on DAY3. New bone emerged near the defect boundary on DAY5 and took the form of trabecular-like structure invaded by microvessels on DAY10. Vascular and bone volume fractions, blood vessel and bone thicknesses, and mineralization were higher on DAY10 than on DAY5. All these parameters were found to be decreased after 10 days of hindlimb unloading, indicating the possible involvement of angiogenesis in bone repair impairment caused by reduced mechanical stimuli. In conclusion, the combined technique of sSRCT and ZrCA vascular casting is suitable for quantitative 3D imaging of angiogenesis and its surrounding bone regeneration. This method will be useful for better understanding the linkage between angiogenesis and bone repair. (Keyword) Animals / Contrast Media / Female / Fractures, Bone / Male / Microvessels / Neovascularization, Physiologic / Osteogenesis / Rats / Rats, Inbred F344 / Rats, Wistar / Statistics, Nonparametric / Stress, Mechanical / Synchrotrons / Tibia / Wound Healing / X-Ray Microtomography / Zirconium (Link to Publication Site) ● Publication site (DOI): 10.1038/labinvest.2013.87 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23835738 ● Summary page in Scopus @ Elsevier: 2-s2.0-84883312055 (DOI: 10.1038/labinvest.2013.87, PubMed: 23835738, Elsevier: Scopus)
16.	Ji-Yean Kwon, Hisashi Naito, Takeshi Matsumoto and Masao Tanaka : Estimation of Change of Bone Structures After Total Hip Replacement Using Bone Remodeling Simulation, Clinical Biomechanics, Vol.28, No.5, 514-518, 2013. (Summary) The principal cause of femoral stem failure is the loosening of the total hip replacement due to bone resorption in the vicinity of the prosthesis (stress shielding). Bone rebuilds its structure continuously according to the daily mechanical stimuli. Therefore, surgical intervention alters the mechanical condition of bone severely. In this study, we propose a method to predict the change of bone structure after total hip replacement using bone remodeling simulation. The bone-stem complex structure model after total hip replacement was reconstructed based on CT-images used for preoperative planning by orthopedic experts. The bone remodeling simulation was conducted under the daily loading condition using our previous remodeling model, and the average equivalent stresses in the Gruen zone were evaluated. The predicted bone loss relevant to stress shielding was consistent to follow-up clinical data. Moreover, the remodeling simulation when using the stems of different size for the same patient could detect the size-dependent change of stress in the Gruen zone. In particular, the zone under the neck of the stem showed significant changes of stress and large bone loss, accompanying the risk of loosening or fracture. Prediction of bone structure changes after total hip replacement gives us significant information for longevity of prosthesis. Simulation results showed that the present computational framework could be considered to have potential in preoperative planning of total hip replacement. (Keyword) Bone Remodeling / Bone Resorption / Equipment Failure Analysis / Femur / Hip Prosthesis / Humans / Models, Biological / Prosthesis Design / Prosthesis Failure / Stress, Mechanical / Tomography, X-Ray Computed (Link to Publication Site) ● Publication site (DOI): 10.1016/j.clinbiomech.2013.04.003 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23647807 ● Summary page in Scopus @ Elsevier: 2-s2.0-84885632859 (DOI: 10.1016/j.clinbiomech.2013.04.003, PubMed: 23647807, Elsevier: Scopus)
17.	權志妍, 内藤尚, 音丸格, 高尾正樹, 佐藤嘉伸, 菅野伸彦, 富山憲幸, Takeshi Matsumoto and 田中正夫 : 人工股関節手術計画における力学的評価指標 -メカノスタット理論/リモデリングシミュレーションからの検討-, 日本臨床バイオメカニクス会誌, Vol.33, 265-269, 2012. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520009410024024704 (CiNii: 1520009410024024704)
18.	Takeshi Matsumoto, Shuichiro Fukushima, Takeshi Kanasaki and Shingo Hagino : Relationship Between Aortic Mineral Elements and Osteodystrophy in Mice With Chronic Kidney Disease, Biological Trace Element Research, Vol.150, No.1-3, 278-284, 2012. (Summary) In chronic kidney disease (CKD), osteodystrophy and arterial calcification often coexist. However, arterial alterations have not been addressed in CKD unaccompanied by evidence of calcification. We investigated the association of phosphate (P) and calcium (Ca) accumulation in calcification-free aortas with CKD-induced osteodystrophy. Aortic accumulation of magnesium (Mg), an inhibitor of calcification, was also examined. Male mice aged 26 weeks with CKD characterized by hyperparathyroidism and hyperphosphatemia (Nx, n = 8) and age-matched healthy male mice (shams, n = 8) were sampled for blood, and thoracic vertebrae and aortas were harvested. Bone structure and chemicals were analyzed by microcomputed tomography and infrared microspectroscopy, respectively, and aortic accumulation of P, Ca, and Mg was evaluated by plasma-atomic emission spectrometry. Volume fractions of cortical and trabecular bones were smaller in Nx than in sham animals (P < 0.05), attributed to cortical thinning and reduction in trabecular number, respectively. Bone chemicals were not different between the groups. No calcification was found in either group, but P, Ca, and Mg contents were higher in Nx than in shams (P < 0.05). The mass ratio of Ca/P was lower in Nx than in shams (P < 0.05), but that of Mg/Ca and Mg/P was not different between the groups. Aortic P and Ca contents were inversely correlated with the volume fraction of cortical bone (P < 0.05). In conclusion, the relationship of osteodystrophy with aortic P and Ca accumulation suggests the existence of a bone-vascular axis, even in calcification-free arteries in CKD. The preservation of ratios of Mg/Ca and Mg/P despite CKD development might contribute to calcification resistance. (Keyword) Animals / Aorta, Thoracic / Calcium / Chronic Kidney Disease-Mineral and Bone Disorder / Disease Resistance / Early Diagnosis / Hyperparathyroidism, Secondary / Hyperphosphatemia / Magnesium / Male / Mice / Mice, Inbred ICR / Phosphorus / Renal Insufficiency, Chronic / Severity of Illness Index / Spectrophotometry, Atomic / Spectrophotometry, Infrared / Thoracic Vertebrae / Tomography, X-Ray Computed / Vascular Calcification (Link to Publication Site) ● Publication site (DOI): 10.1007/s12011-012-9466-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22700181 ● Search Scopus @ Elsevier (PMID): 22700181 ● Search Scopus @ Elsevier (DOI): 10.1007/s12011-012-9466-x (DOI: 10.1007/s12011-012-9466-x, PubMed: 22700181)
19.	Hisashi Naito, Yasushi Akazawa, Ayu Miura, Takeshi Matsumoto and Masao Tanaka : Identification of Individual Muscle Length Parameters From Measurements of Passive Joint Moment Around the Ankle Joint, Journal of Biomechanical Science and Engineering, Vol.7, 168-176, 2012. (Link to Publication Site) ● Publication site (DOI): 10.1299/jbse.7.168 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84866506265 (DOI: 10.1299/jbse.7.168, Elsevier: Scopus)
20.	Takako Osawa, Takeshi Matsumoto, Hisashi Naito and Masao Tanaka : Evaluation of Viscoelastic Property of Articular Cartilage Based on Mechanical Model Considering Tissue Microstructure, Journal of Biomechanical Science and Engineering, Vol.7, No.1, 31-42, 2012. (Link to Publication Site) ● Publication site (DOI): 10.1299/jbse.7.31 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-84860824919 (DOI: 10.1299/jbse.7.31, Elsevier: Scopus)
21.	Takeshi Matsumoto, Takushi Miyakawa and Daiki Yamamoto : Effects of Vitamin K on the Morphometrical and Material Properties of Bone in The Tibiae of Growing Rats, Metabolism: Clinical and Experimental, Vol.61, No.3, 407-414, 2011. (Summary) Suboptimal vitamin K nutriture is evident during rapid growth. We aimed to determine whether vitamin K(2) (menaquinone-4 [MK-4]) supplementation is beneficial to bone structure and intrinsic bone tissue properties in growing rats. Male Wistar rats (5 weeks old) were assigned to either a control diet (n = 8) or an MK-4-supplemented diet (22 mg d(-1) kg(-1) body weight, n = 8). After a 9-week feeding period, we determined the serum concentration ratio of undercarboxylated osteocalcin to -carboxylated osteocalcin and the urinary deoxypyridinoline level. All rats were then euthanized, and their tibiae were analyzed by micro-computed tomography for trabecular architecture and synchrotron radiation micro-computed tomography for cortical pore structure and mineralization. Fourier transform infrared microspectroscopy and a nanoindentation test were performed on the cortical midlayers of the anterior and posterior cortices to assess bone tissue properties. Neither body weight nor tibia length differed significantly between the 2 groups. Dietary MK-4 supplementation decreased the ratio of undercarboxylated osteocalcin to -carboxylated osteocalcin but did not affect deoxypyridinoline, indicating a positive effect on bone formation but not bone resorption. Trabecular volume fraction and thickness were increased by MK-4 (P < .05). Neither the cortical pore structure nor mineralization was affected by MK-4. On the other hand, MK-4 increased mineral crystallinity, collagen maturity, and hardness in both the anterior and posterior cortices (P < .05). These data indicate the potential benefit of MK-4 supplementation during growth in terms of enhancing bone quality. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.metabol.2011.07.018 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21944271 ● Search Scopus @ Elsevier (PMID): 21944271 ● Search Scopus @ Elsevier (DOI): 10.1016/j.metabol.2011.07.018 (DOI: 10.1016/j.metabol.2011.07.018, PubMed: 21944271)

Review, Commentary:

1.	Takeshi Matsumoto : Exploring the impact of whole-body vibration on bone metastasis and vascularization in a murine model of breast cancer, SPring-8/SACLA Research Frontiers 2023, 38-39, 2024.
2.	Takeshi Matsumoto : 放射光CTによる皮質骨ポア構造解析, 日本臨牀増刊号: 最新の骨粗鬆症学, 63-67, Apr. 2013.

Proceeding of International Conference:

1.	Takeshi Matsumoto, Hiroyuki Tachibana and Masato Hoshino : Phase Contrast X-ray CT for Imaging of the Entire Circumferential Structure of Arteries Under Pulsatile Pressure Condition, Physiology 2021: The Abstract Book, 346-349, Online, Jul. 2021.
2.	Takeshi Matsumoto, Hiroyuki Tachibana and Masato Hoshino : Time-series Snapshots of the Entire Circumferential Wall of Arteries Under Pulsatile Pressure Condition Captured by Grating-based Phase-contrast CT, Proc. ESCHM-ISCH-ISB 2021, P1-06, Online, Jul. 2021.
3.	Takako Osawa, Tatsuhiro Aoki, Tomoya Konishi, Shinji Tatsumi, Masato Hoshino and Takeshi Matsumoto : Dynamic 3D Imaging of Articular Cartilage Under Repetitive Compression Measured by Phase-Contrast X-ray CT, Proc. 17th Int. Conf. Biomed. Eng., 1376, Singapore, Dec. 2019.
4.	Takeshi Matsumoto and Kawahito Yuya : Bone-Anabolic Action of Low-Intensity Whole-Body Vibration and the Involvement of Bone Vascularization in Juvenile Mic, IUPESM 2018 Book of Abstracts, 569-570, Praha, Jun. 2018.
5.	Shinya Itamochi and Takeshi Matsumoto : Combined Effect of Whole-body Vibration and Parathyroid Hormone on Bone Structure and Material Properties of Ovariectomized Mice, Physiology 2016 Abstracts, 356-357, Dublin, Jul. 2016.
6.	Takeshi Matsumoto and Shinya Itamochi : Effects of Whole Body Vibration on Breast Cancer Bone Metastasis and Vascularization in Mice, Physiology 2016 Abstracts, 166, Dublin, Jul. 2016.
7.	Takeshi Matsumoto, Shinya Itamochi and Shota Sato : Bone and Microvascular Imaging by K-edge Subtraction µCT Using Synchrotron Lights With Zirconia Contrast Medium, Proc.10th World Cong. Microcirc., 76, Kyoto, Sep. 2015.
8.	Takako Osawa, Takeshi Matsumoto, Hisashi Naito and Masao Tanaka : Tissue/Material Properties of Enzymatically-Degenerated Articular Cartilage Evaluated by Using Viscoelastic Model Considering Depth-Dependent Microstructure, Pro. 11th World Cong. Comput. Mech., a3543-1-a3543-2, Barcelona, Jul. 2015.
9.	Hiroshi Kobayashi, Toshihiro Sera, Takeshi Matsumoto and Masao Tanaka : Computational Analysis of Physiological Substance Concentration in Cortical Bone Considering Lacunar-Canalicular Network, Pro. 1st Global Conf. Biomed. Eng., OB32-1-OB32-2, Tainan, Oct. 2014.
10.	Yoshihiro Hashimoto, Takeshi Matsumoto and Masao Tanaka : Synergetic Effect of Whole-Body Vibration and Parathyroid Hormone (1-34) on Regenerated Bone Quality During Defect Healing, Pro. 1st Global Conf. Biomed. Eng., OA22-1-OA22-3, Tainan, Oct. 2014.
11.	Takeshi Matsumoto, Shota Sato and Daichi Goto : Whole-body Vibration With Extremely Low-Aamplitude Accelerates Early-Stage Bone Defect Healing With Reducing Angiogenesis, Proc. European Calcified Tissue Society Congress 2014, 49, Praha, May 2014.
12.	Shota Sato, Takeshi Matsumoto, Hisashi Naito and Masao Tanaka : Involvement of Angiogenesis in Early-Stage Bone Repair, Proc. 35th Ann. Int. Conf. IEEE Eng. Med. Biol., a3238-1, Osaka, Jul. 2013.
13.	Takeshi Matsumoto, Shota Sato and Daichi Goto : Deferoxamine Alleviates Unloading-Induced Delay of Bone Defect Repair, Proc. 2nd Joint Meeting of IBMS and JSBMR (IBMS BoneKEy 10), S43, Kobe, Jun. 2013.
14.	Takeshi Matsumoto : Quantitative Bone CT Using Synchrotron Source, Proc. 2013 Spring Meeting of KSME Bioeng. Div., 1, Yeosu, May 2013.
15.	Takaki Nakayama, Hisashi Naito, Takeshi Matsumoto and Masao Tanaka : Optimal Cornea Shape Design Problem for Corneal Refractive Surgery, Proc. 10th World Cong. Struct. Multidiscip. Optim., 1-7, Orlando, May 2013.
16.	Takeshi Matsumoto, Sato Shota and Goto Daichi : Hypoxia-Inducible Factor-Mediated Enhancement of Angiogenesis Reduces the delay of bone defect healing caused by mechanical unloading, Physiology 2012, 234, Edinburgh, Jul. 2012.
17.	Kwon Jiyean, Naito Hisashi, Takeshi Matsumoto, Otomal Itaru, Takao Masaki, Sato Yoshinobu, Sugano Nobuhiko and Tanaka Masao : Simulation Study of Bone Loss After Total Hip Replacement, Journal of Biomechanics, Vol.45, No.S1, S110, Lisbon, Jul. 2012.

Proceeding of Domestic Conference:

1.	Shota Kohno and Takeshi Matsumoto : 全身性微振動刺激による骨粗鬆症改善作用の多角的検討, 日本機械学会中国四国支部第62期総会・講演会講演論文集, 01c1, Mar. 2024.
2.	Takumi Aoki and Takeshi Matsumoto : 乳がん骨転移における全身性微振動刺激の骨質に対する作用評価, 日本機械学会中国四国支部第62期総会・講演会講演論文集, 01d1, Mar. 2024.
3.	Takeshi Matsumoto, Keishi Hashimoto and Hyuga Okada : 全身性微振動刺激による骨修復促進および血管構築の関与, 第43回日本骨形態計測学会・抄録号, Vol.33, No.1, 159, Jun. 2023.
4.	Koki Kunimori and Takeshi Matsumoto : 全身性微振動刺激の断続性が骨量・骨質改善および骨代謝に及ぼす効果について, 第33回バイオフロンティア講演会・講演論文集, 2F04, Dec. 2022.
5.	Takeshi Matsumoto and Koki Kunimori : 微振動刺激の断続化が骨構築・組織に及ぼす影響, 第42回日本骨形態計測学会・抄録号, Vol.32, No.1, S193, Jul. 2022.
6.	國森皓貴 and Takeshi Matsumoto : 全身性の断続的微振動刺激による骨質向上作用の放射光CT/ ラマン分光解析, 第61回日本生体医工学会大会・抄録集, 157, Jun. 2022.
7.	Koki Kunimori, Fumiaki Yamagishi and Takeshi Matsumoto : 全身性微振動刺激による骨質改善作用および刺激の断続性の効果について, 第32回バイオフロンティア講演会・講演論文集, 2B13, Jan. 2022.
8.	Fumiaki Yamagishi, Koki Kunimori and Takeshi Matsumoto : 全身性微振動刺激の断続性が骨粗鬆症の予防効果に及ぼす影響の検討, 第44回日本生体医工学会中国四国支部大会・講演抄録, III-01, Nov. 2021.
9.	Takeshi Matsumoto and Akihiro Mukohara : 乳がん骨転移における全身性微振動刺激作用の放射光CT, 第41回日本骨形態計測学会・抄録号, Vol.31, No.2, S118, Jul. 2021.
10.	Takeshi Matsumoto and Akihiro Mukohara : 乳がん骨転移マウスモデルに対する全身性微振動刺激の有効性の検証, 第33回バイオエンジニアリング講演会・論文集, 2B5-01, Jun. 2021.
11.	OKADA Hiyuga, Keishi Hashimoto and Takeshi Matsumoto : 全身性微振動刺激の断続不規則性が骨修復促進に及ぼす効果について, 生体医工学シンポジウム2020・抄録集, 1A-24, Sep. 2020.
12.	Takeshi Matsumoto and 上杉健太朗 : 位相コントラストX線CTによる骨修復モニタリング, 第40回日本骨形態計測学会・抄録号, Vol.30, No.1, S108, Jun. 2020.
13.	Yuto Tanaka, Yuya Kawahito and Takeshi Matsumoto : 骨粗鬆症抑制に対する全身微振動刺激の持続的効果について, 第59回日本生体医工学会大会・抄録集, 330, May 2020.
14.	Shusaku Kawano, 大澤恭子, 星野真人 and Takeshi Matsumoto : 関節軟骨局所変形解析のためのX線位相差ダイナミックCTの開発, 第59回日本生体医工学会大会・抄録集, 329, May 2020.
15.	Shusaku Kawano, 大澤恭子, 星野真人 and Takeshi Matsumoto : X線位相差ダイナミック CT による関節軟骨変形解析, 第32回バイオエンジニアリング講演会・論文集, 1B-22, Dec. 2019.
16.	Yuto Tanaka, Yuya Kawahito and Takeshi Matsumoto : 全身微振動刺激による骨粗鬆症抑制効果の継続性について, 生体医工学シンポジウム2019・抄録集, 1A-15, Sep. 2019.
17.	Shusaku Kawano, Tomoaki Takeda, Takako Osawa and Takeshi Matsumoto : 関節軟骨の機能解析を目的としたX線位相差CTによるダイナミック3Dイメージング, 生体医工学シンポジウム2019・抄録集, 1A-18, Sep. 2019.
18.	Shusaku Kawano, Tomoaki Takeda and Takeshi Matsumoto : X線位相差CTによる関節軟骨のダイナミック3Dイメージング, IEICE Technical Report, Vol.119, No.137, 39-41, Jul. 2019.
19.	Yuta Kameyama, Yosuke Iki, Takeshi Matsumoto, Takeo Minamikawa, Takeshi Yasui and Katsuya SATO : Influence of intermittent vibration stimuli on osteoblasts matrix production, 第30回バイオフロンティア講演会講演論文集, 2A31, Jul. 2019.
20.	Keishi Hashimoto and Takeshi Matsumoto : 骨粗鬆症マウスの骨欠損修復における断続性微振動刺激の効果, 日本機械学会中国四国支部第57期総会・講演会講演論文集, 108, Mar. 2019.
21.	Yuya Kawahito and Takeshi Matsumoto : 微振動刺激による骨粗鬆症抑制効果と骨微小循環構築の関与:休止期挿入による影響について, 日本機械学会中国四国支部第57期総会・講演会講演論文集, 107, Mar. 2019.
22.	Takako Osawa, Masato Hoshino and Takeshi Matsumoto : Dynamic phase contrast X-ray CT of articular cartilage under repetitive compression, 第31回バイオエンジニアリング講演会・講演論文集, 1E24, Dec. 2018.
23.	Keishi Hashimoto and Takeshi Matsumoto : Whole-body vibration with irregular rest interval promotes bone defect healing in ovariectomized mice, 第31回バイオエンジニアリング講演会・講演論文集, 1B15, Dec. 2018.
24.	Katsuya SATO, Shota Okazawa, Yuta Kameyama, Takeshi Matsumoto, Takeo Minamikawa and Takeshi Yasui : Enhancement of osteoblastic matrix synthesis by using mechanical vibration stimuli, 第31回バイオエンジニアリング講演会論文集, 1F31, Dec. 2018.
25.	Yuta Kameyama, Takeshi Matsumoto, Takeo Minamikawa, Takeshi Yasui and Katsuya SATO : Investigation of vibration condition to enhance osteoblasts proliferation and matrix mineralization, 第29回バイオフロンティア講演会論文集, 1A21, Oct. 2018.
26.	Keishi Hashimoto and Takeshi Matsumoto : Effects of Rest Insertion Combined with Whole-Body Vibration on Bone Healing in Ovariectomized Mice, 第57回日本生体医工学会大会抄録集, 489, Jun. 2018.
27.	Yuya Kawahito and Takeshi Matsumoto : Bone-anabolic action of low-intensity vibratory stimulation and the involvement of bone microvascularity, 第30回バイオエンジニアリング講演会・講演論文集, 264, Dec. 2017.
28.	Takeshi Matsumoto : 骨リモデリング・再生における微振動刺激作用の検証, 第44回日本臨床バイオメカニクス学会・抄録集, 87, Nov. 2017.
29.	宇治田俊樹 and Takeshi Matsumoto : がん骨転移における微振動刺激の作用関す実験的検証, 第28回バイオフロンティア講演会・講演論文集 USB, C15, Oct. 2017.
30.	川人侑弥 and Takeshi Matsumoto : Bone anabolic effect of low-intensity vibratory stimulation and the involvement of bone micro-vasculature, 第28回バイオフロンティア講演会・講演論文集 USB, C14, Oct. 2017.
31.	Yuya Kawahito and Takeshi Matsumoto : 全身性微振動刺激が骨および骨微小血管分布に及ぼす影響 : 放射光CT による検討, JBMES2017 Proceedings, 114, Sep. 2017.
32.	Okazawa Shota, Takeshi Matsumoto, Takeshi Yasui, Takeo Minamikawa and Katsuya SATO : 骨芽細胞のコラーゲン産生における振動・ストレッチ複合刺激の影響, 日本機械学会2017年年次大会, S0210201, Sep. 2017.
33.	清水亮汰 and Takeshi Matsumoto : Monitoring of Bone Repair Process by In-Line Phase-Contrast CT: Evaluation of Osteoporotic Bone Repair in Mice, 第56回日本生体医工学会大会抄録集, 324, May 2017.
34.	Ryota Shimizu and Takeshi Matsumoto : 放射光位相CTに基づく⾻構造ダイナミクスのインビボイメージング:マウス骨欠損モデルへの応用, 日本機械学会中国四国支部第55期総会・講演会講演論文集, Mar. 2017.
35.	Yuya Kawahito and Takeshi Matsumoto : 全身性微振動刺激による骨構造への影響と骨微小血管形成の関与, 日本機械学会中国四国支部第55期総会・講演会講演論文集, Mar. 2017.
36.	Shota Okazawa, Takeshi Matsumoto, Takeshi Yasui, Takeo Minamikawa and Katsuya SATO : Enhancement of osteoblastic collagen synthesis under combined vibration and stretching stimulation, 日本機械学会中国四国支部第55期総会・講演会講演論文集, Feb. 2017.
37.	清水亮太 and Takeshi Matsumoto : 骨粗鬆症における骨修復遅延およびepoxyeeicosatrienoic acid による骨修復改善効果の解析:放射光位相CTによる検討, 第39回日本生体医工学会中国四国支部大会・講演抄録, 14, Oct. 2016.
38.	宇治田俊樹 and Takeshi Matsumoto : がん骨破壊に対する全身性微振動刺激の作用について:インビボ位相 CT に基づく検討, JBMES2016 Proceedings, 57, Sep. 2016.
39.	板持伸弥, Takeshi Matsumoto and 田中正夫 : がん骨破壊に対する全身性高周波微振動負荷の抑制作用の検討, 日本機械学会関西支部第91期総会・講演会講演論文集, 355, Mar. 2016.
40.	板持伸弥, Takeshi Matsumoto and 田中正夫 : 骨粗鬆症マウスモデルに対する全身性微振動負荷および副甲状腺ホルモン投与の併用効果の検証, 第54回日本生体医工学会大会抄録集, 255, May 2015.

Et cetera, Workshop:

1.	Takeshi Matsumoto : 骨形態・機能のマイクロスコピック解析, 日本生体医工学会専門別研究会・第158回バイオメカニクス研究会, Jan. 2016.

Report:

1.	Takeshi Matsumoto : 拍動する血管壁の微細構造ダイナミクスを捉えるX線位相差CTシステムの開発, 中谷医工計測技術振興財団年報, Vol.35, 151-156, Apr. 2022.
2.	Takeshi Matsumoto : 血管壁内の動的な局所変形を捉える位相差ダイナミックCTによる血管マイクロダメージの評価手法の確立, 福田記念医療技術振興財団情報, Vol.32, 171-178, Dec. 2019.
3.	Takeshi Matsumoto : 骨粗鬆症患者の骨折治療を目的とした全身性ランダム様微振動の骨修復促進に関する実験的研究, 医科学応用研究財団研究報告, Vol.36, 134-138, Feb. 2019.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

全身性微振動刺激による乳がん骨転移予防：刺激の断続化による効果増大の実験的検証 (Project/Area Number: 24K02798 )
4D imaging of arterial-wall fiber structure under pulsatile conditions by using synchrotron radiation phase-contrast CT (Project/Area Number: 20K21899 )
4D imaging of bio-soft material deformation based on phase-contrast CT using synchrotron light (Project/Area Number: 18K19926 )
Epigenetic analysis of new bone remodeling mechanism in the dentofacial region. (Project/Area Number: 18H03011 )
Experimental study on preventive effect of whole body vibration on metastatic progression of breast cancer to bone (Project/Area Number: 15K12509 )
Effects of whole body vibration on cancer-induced bone destruction (Project/Area Number: 26282120 )
Effectiveness of noise-like vibration loading in preventing osteoporosis (Project/Area Number: 24650265 )
Experiment research on the therapeutic impact of low-magnitude vibrations on eraly-stage bone healing (Project/Area Number: 23300165 )
Inhibitory effect of vitamin K2 on vascular calcification and osteoporosis : experimental approach to understanding the bone-vascular axis (Project/Area Number: 21650112 )
Experimental research on the development of a new therapy for bone injury via sympathetic nerve system (Project/Area Number: 20300158 )
発育期の骨質強化に対する力学的負荷およびビタミンK摂取の有効性に関する実験的研究 (Project/Area Number: 19650116 )
単色放射光CTによる骨内局所潅流および骨微細構造の同時評価法の開発 (Project/Area Number: 17650138 )
Study on the angiogenesis-mediated promotion of bone fracture healing using repeated stimuli induced by microbubble destruction (Project/Area Number: 17300152 )
Development of the imaging system to evaluate of blood flow distribution and metabolic activity in myocardial microcirculation. (Project/Area Number: 15300174 )
Analysis and modeling of micro- or nano-scale structure and microcirculation of bone (Project/Area Number: 15086210 )
リアルタイムグラメトリシステムの開発と8GeV放射光心筋微小血管造影への応用 (Project/Area Number: 14658298 )
細胞表面および細胞内部への応力負荷に対する内皮細胞内情報伝達メカニズムの解析 (Project/Area Number: 14658297 )
Evaluation of dynamic changes of nitric oxide and oxidative stress in hemodialysis patients (Project/Area Number: 13680961 )
Analysis of cardiac lymphatic dynamics in beating canine hearts using a high-speed CCD microscope (Project/Area Number: 13670773 )
Analysis of cardiac lymphatic dynamics in beating canine hearts using a high-speed CCD microscope (Project/Area Number: 13670772 )
Functional Morphology of Coronary Arteriol.es in Relation to Coronary Microcirculatory Disturbance by Micro-imaging Techniques (Project/Area Number: 12670714 )
Development of Pencil-type CCD Microscope for evaluating of renal glomerular microcirculation with normal and hypertensive Rat (Project/Area Number: 12557065 )
SPring8放射光を用いた重元素ステレオ造影による心筋微小血管ダイナミクス解析 (Project/Area Number: 12480269 )
ダブル分子血流トレーサを利用した冠細動脈塞栓後の心筋微小循環異常の経時的計測 (Project/Area Number: 11770388 )
Analysis of abnormal coronary micro-circulation in a diabetic or hypertensive rat heart by simultaneous measurement of NADH fluorescence and blood flow distribution (Project/Area Number: 11680856 )
Endothelium-dependent and -independent responses of coronary arteriole to pulsatile mechanical stress in vivo (Project/Area Number: 10670694 )
Analysis on local blood flow, metabolic NADH distribution and micro-mechanical dysfunction during ischaemia of coronary micro-circulation (Project/Area Number: 10670686 )
Analysis on myocardial ischemia by observation of NADH fluorescence/oxygen partial pressure phosphorescence using an intra-vital needle microscope (Project/Area Number: 10558140 )
Evaluation of the interaction between myogenic response and endothelium-derived factor by a microvessel perfusion system (Project/Area Number: 10555292 )
血管内皮由来一酸化窒素を介する大動脈内バルーンパンピングの冠循環改善効果の評価 (Project/Area Number: 09770925 )
Analysis of vasodilated effect of nitroglycerin on microvessels us ing a high speed CCD microscope (Project/Area Number: 09670775 )
Analysis on intramyocardial microcirculation by a high-speed CCD intravitalmicroscope with a visual servo manipulator (Project/Area Number: 09558125 )
Three-dimensional imaging of myocardial blood flow with microcomputed (Project/Area Number: 09555133 )
虚血・再潅流後の心筋微小循環heterogeneityの病態生理学的意義について (Project/Area Number: 08770541 )
Evaluation of Subendocardial Microcirculatory Hemodynamics by High-Speed Needle-Probe CCD Microscope (Project/Area Number: 08558103 )
Development of 3-D Evaluation System of Microheterogeneity of Intramyocardial Flow Using Molecular Flow Tracers (Project/Area Number: 08557051 )
Development of Measuring System of Endothelium-Derived Relaxing Factor(NO)and Vascular Luminal Shear Stress (Project/Area Number: 08555207 )
分子血流トレーサを用いた冠微小循環調節系の時間的応答の解明 (Project/Area Number: 07780794 )
Analysis of vasodilated effect of nitroglycerin on microvessels (Project/Area Number: 07670828 )
Evaluation of Coronary Vasoregulation Through Controlling Regional Myocardial Flow (Project/Area Number: 07558134 )
Computational fluiddynamical analysis of correlations between blood flow and LDL at the vascular location where atherosclerosis occurs preferentially (Project/Area Number: 06680868 )
Developement of side-on typed needle-probe for CCD microscope (Project/Area Number: 06558130 )
Time-serial analysis of position of LDL and infiltration of monocyte in vascular wall by laser scanning confocal microscope (Project/Area Number: 06558129 )
Evaluation of myocardial blood flow heterogeneity by using molecular deposition technique and fractal analysis (Project/Area Number: 05680768 )
Development of Micro-Probe for Continuous Sampling of Interstitial Fluid in Myocardium for Evaluation of Physiological Circulation, Control, and Mass Transport. (Project/Area Number: 05558119 )
A High Resolution CCD Intravital Fluorescent Microscope for Observation of Coronary Smaller Microvessels in a Beating Heart (Project/Area Number: 05557043 )
Analysis of Coronary Slosh Phenomenon by Needle-probe CCD Microscope and Molecular Blood Flow Tracer (Project/Area Number: 05454278 )
血流の流体力学的構造と血管内皮細胞の立体的形状の相互関連性の解析 (Project/Area Number: 05221239 )
Study on the subendocardial ischemia using a high resolution needle-probe video-microscope with a CCD camera (Project/Area Number: 04670569 )
血管内皮配列と微細形態観察のための冠血管鋳型・レーザースキャン顕微鏡解析法の開発 (Project/Area Number: 04557043 )
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Professor : Matsumoto, Takeshi

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)