徳島大学 / 教育研究者総覧 --- 髙成広起

個人のホームページ

https://researchmap.jp/hiroki_takanari (researchmap)

https://orcid.org/0000-0001-9348-9877 (ORCID)

専門分野

○	ライフサイエンス (Life sciences) [生体医工学 (Biomedical engineering)]
○	ライフサイエンス (Life sciences) [医療薬学 (Clinical pharmacy)]
○	ライフサイエンス (Life sciences) [生理学 (Physiology)]
○	ライフサイエンス (Life sciences) [循環器内科学 (Cardiology)]
○	ライフサイエンス (Life sciences) [医療薬学 (Clinical pharmacy)]
○	ライフサイエンス (Life sciences) [生理学 (Physiology)]

研究テーマ

著書・論文

学術論文(審査論文):

1.	Shin-ichiro Yanagiya, Takeshi Honda, Hiroki Takanari, Kimiko Sogabe, Shingen Nakamura, Yoshimi Bando, Masahiro Abe and Hirokazu Miki : Raman Microspectroscopy for Label-Free Diagnosis of Amyloid Light-chain Amyloidosis in Various Organs, Journal of Raman Spectroscopy, 2024. (キーワード) ラマン顕微分光法 / 全身性アミロイドーシス / タンパク質 (protein) / 光学顕微鏡法 (徳島大学機関リポジトリ) ● Metadata: 119087 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jrs.6665 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1002/jrs.6665 (徳島大学機関リポジトリ: 119087, DOI: 10.1002/jrs.6665)
2.	Saya Matsuzaki, Eiji Hase, Hiroki Takanari, Yuri Hayashi, Yusaku Hayashi, Haruto Oshikata, Takeo Minamikawa, Satoko Kimura, Mayuko Shimizu, Takeshi Yasui, Masafumi Harada and Koichi Tsuneyama : Quantification of collagen fiber properties in alcoholic liver fibrosis using polarization-resolved second harmonic generation microscopy., Scientific Reports, Vol.13, No.1, 22100, 2023. (要約) Liver fibrosis is assessed mainly by conventional staining or second harmonic generation (SHG) microscopy, which can only provide collagen content in fibrotic area. We propose to use polarization-resolved SHG (PR-SHG) microscopy to quantify liver fibrosis in terms of collagen fiber orientation and crystallization. Liver samples obtained from autopsy cases with fibrosis stage of F0-F4 were evaluated with an SHG microscope, and 12 consecutive PR-SHG images were acquired while changing the polarization azimuth angle of the irradiated laser from 0° to 165° in 15° increments using polarizer. The fiber orientation angle (φ) and degree (ρ) of collagen were estimated from the images. The SHG-positive area increased as the fibrosis stage progressed, which was well consistent with Sirius Red staining. The value of φ was random regardless of fibrosis stage. The mean value of ρ (ρ-mean), which represents collagen fiber crystallinity, varied more as fibrosis progressed to stage F3, and converged to a significantly higher value in F4 than in other stages. Spatial dispersion of ρ (ρ-entropy) also showed increased variation in the stage F3 and decreased variation in the stage F4. It was shown that PR-SHG could provide new information on the properties of collagen fibers in human liver fibrosis. (キーワード) Humans / Second Harmonic Generation Microscopy / Collagen / Liver Cirrhosis / Refraction, Ocular / Coloring Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-023-48887-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 38092851 ● Search Scopus @ Elsevier (PMID): 38092851 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-48887-8 (DOI: 10.1038/s41598-023-48887-8, PubMed: 38092851)
3.	Masatoshi Yamazaki, Naoki Tomii, Koichi Tsuneyama, Hiroki Takanari, Ryoko Niwa, Haruo Honjo, Itsuo Kodama, Tatsuhiko Arafune, Naomasa Makita, Ichiro Sakuma, Dobromir Dobrev, Stanley Nattel and Yukiomi Tsuji : Rotors anchored by refractory islands drive torsades de pointes in an experimental model of electrical storm., Heart Rhythm, Vol.19, No.2, 318-329, 2021. (要約) Optical mapping revealed island-like regions with action potential duration (APD) prolongation in the left ventricle, leading to increased spatial APD dispersion, in rabbits with ES (defined as ≥3 VF episodes/24 h). The maximum APD and its dispersion correlated with the total number of VF episodes in vivo. TdP was initiated by an ectopic beat that failed to enter the island and formed a reentrant wave and perpetuated by rotors whose centers swirled in the periphery of the island. Epinephrine exacerbated the island by prolonging APD and enhancing APD dispersion, which was less evident after late Na (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.hrthm.2021.10.012 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34678525 ● Search Scopus @ Elsevier (PMID): 34678525 ● Search Scopus @ Elsevier (DOI): 10.1016/j.hrthm.2021.10.012 (DOI: 10.1016/j.hrthm.2021.10.012, PubMed: 34678525)
4.	Takeo Minamikawa, Mayuko Shimizu, Hiroki Takanari, Yuki Morimoto, Ryosuke Shiomi, Tanioka Hiroki, Eiji Hase, Takeshi Yasui and Koichi Tsuneyama : Molecular imaging analysis of microvesicular and macrovesicular lipid droplets in non-alcoholic fatty liver disease by Raman microscopy., Scientific Reports, Vol.10, No.1, 18548, 2020. (要約) Predominant evidence of non-alcoholic fatty liver disease (NAFLD) is the accumulation of excess lipids in the liver. A small group with NAFLD may have a more serious condition named non-alcoholic steatohepatitis (NASH). However, there is a lack of investigation of the accumulated lipids with spatial and molecular information. Raman microscopy has the potential to characterise molecular species and structures of lipids based on molecular vibration and can achieve high spatial resolution at the organelle level. In this study, we aim to demonstrate the feasibility of Raman microscopy for the investigation of NAFLD based on the molecular features of accumulated lipids. By applying the Raman microscopy to the liver of the NASH model mice, we succeeded in visualising the distribution of lipid droplets (LDs) in hepatocytes. The detailed analysis of Raman spectra revealed the difference of molecular structural features of the LDs, such as the degree of saturation of lipids in the LDs. We also found that the inhomogeneous distribution of cholesterol in the LDs depending on the histology of lipid accumulation. We visualised and characterised the lipids of NASH model mice by Raman microscopy at organelle level. Our findings demonstrated that the Raman imaging analysis was feasible to characterise the NAFLD in terms of the molecular species and structures of lipids. (徳島大学機関リポジトリ) ● Metadata: 115619 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-020-75604-6 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33122711 ● Search Scopus @ Elsevier (PMID): 33122711 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-020-75604-6 (徳島大学機関リポジトリ: 115619, DOI: 10.1038/s41598-020-75604-6, PubMed: 33122711)
5.	Eiji Hase, Hiroki Takanari, Keita Hoshi, Masaki Okamoto, Atsushi Tabata, Hideaki Nagamune, Takeo Minamikawa, Takeshi Yasui, Yasushi Yoshida, Keiji Minagawa, Yasuhiko Kawamura, Yasushi Imada and Fumitoshi Yagishita : Two- and three-photon excitable quaternized imidazo[1,2-a]pyridines for mitochondrial imaging and potent cancer therapy agent, Organic & Biomolecular Chemistry, Vol.18, No.38, 7571-7576, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.1039/D0OB01585G (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32940324 ● Search Scopus @ Elsevier (PMID): 32940324 ● Search Scopus @ Elsevier (DOI): 10.1039/D0OB01585G (DOI: 10.1039/D0OB01585G, PubMed: 32940324)
6.	Satoru Hashimoto, Hiroki Takanari, Emmanuel Compe and Jean-Marc Egly : Dysregulation of LXR responsive genes contribute to ichthyosis in Trichonthiodystrophy, Journal of Dermatological Science, Vol.97, No.3, 201-207, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jdermsci.2020.01.012 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.jdermsci.2020.01.012 (DOI: 10.1016/j.jdermsci.2020.01.012)
7.	Fumitoshi Yagishita, Jun-ichi Tanigawa, Chiho Nii, Atsushi Tabata, Hideaki Nagamune, Hiroki Takanari, Yasushi Imada and Yasuhiko Kawamura : Fluorescent Imidazo[1,5-a]pyridinium Salt for a Potential Cancer Therapy Agent, ACS Medicinal Chemistry Letters, Vol.10, No.8, 1110-1114, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.1021/acsmedchemlett.9b00034 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1021/acsmedchemlett.9b00034 (DOI: 10.1021/acsmedchemlett.9b00034)
8.	FangFang Ma, Hiroki Takanari, Kimiko Masuda, Masaki Morishima and Katsushige Ono : Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil., Heart and Vessels, Vol.31, No.7, 1176-1184, 2016. (要約) Bepridil is an effective antiarrhythmic drug on supraventricular and ventricular arrhythmias, and inhibitor of calmodulin. Recent investigations have been elucidating that bepridil exerts antiarrhythmic effects through its acute and chronic application for patients. The aim of this study was to identify the efficacy and the potential mechanism of bepridil on the inward-rectifier potassium channel in neonatal rat cardiomyocytes in acute- and long-term conditions. Bepridil inhibited inward-rectifier potassium current (I K1) as a short-term effect with IC50 of 17 μM. Bepridil also reduced I K1 of neonatal cardiomyocytes when applied for 24 h in the culture medium with IC50 of 2.7 μM. Both a calmodulin inhibitor (W-7) and an inhibitor of calmodulin-kinase II (KN93) reduced I K1 when applied for 24 h as a long-term effect in the same fashion, suggesting that the long-term application of bepridil inhibits I K1 more potently than that of the short-term application through the inhibition of calmodulin kinase II pathway in cardiomyocytes. (キーワード) Animals / Animals, Newborn / Anti-Arrhythmia Agents / Benzylamines / Bepridil / Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Calmodulin / Cells, Cultured / Membrane Potentials / Myocytes, Cardiac / Potassium Channel Blockers / Potassium Channels, Inwardly Rectifying / Protein Kinase Inhibitors / Rats, Wistar / Sulfonamides / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00380-015-0762-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26498939 ● Search Scopus @ Elsevier (PMID): 26498939 ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-015-0762-1 (DOI: 10.1007/s00380-015-0762-1, PubMed: 26498939)
9.	Masaki Morishima, Eriko Iwata, Chisato Nakada, Yoshiyuki Tsukamoto, Hiroki Takanari, Shinji Miyamoto, Masatsugu Moriyama and Katsushige Ono : Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K(+) Channel, IK.ACh., Circulation Journal, Vol.80, No.6, 1346-1355, 2016. (要約) Atrial fibrillation (AF) begets AF in part due to atrial remodeling, the molecular mechanisms of which have not been completely elucidated. This study was conducted to identify microRNA(s) responsible for electrical remodeling in AF. The expression profiles of 1205 microRNAs, in cardiomyocytes from patients with persistent AF and from age-, gender-, and cardiac function-matched control patients with normal sinus rhythm, were examined by use of a microRNA microarray platform. Thirty-nine microRNAs differentially expressed in AF patients' atria were identified, including miR-30d, as a candidate responsible for ion channel remodeling by in silico analysis. MiR-30d was significantly upregulated in cardiomyocytes from AF patients, whereas the mRNA and protein levels ofCACNA1C/Cav1.2 andKCNJ3/Kir3.1, postulated targets of miR-30d, were markedly reduced.KCNJ3/Kir3.1 expression was downregulated by transfection of the miR-30 precursor, concomitant with a reduction of the acetylcholine-sensitive inward-rectifier K(+)current (IK.ACh).KCNJ3/Kir3.1 (but notCACNA1C/Cav1.2) expression was enhanced by the knockdown of miR-30d. The Ca(2+)ionophore, A23187, induced a dose-dependent upregulation of miR-30d, followed by the suppression ofKCNJ3mRNA expression. Blockade of protein kinase C signaling blunted the [Ca(2+)]i-dependent downregulation of Kir3.1 via miR-30d. The downward remodeling ofIK.AChis attributed, at least in part, to deranged Ca(2+)handling, leading to the upregulation of miR-30d in human AF, revealing a novel post-transcriptional regulation ofIK.ACh. (Circ J 2016; 80: 1346-1355). (キーワード) Aged / Atrial Fibrillation / Case-Control Studies / Cells, Cultured / Down-Regulation / 女性 (female) / GTP-Binding Proteins / Humans / 男性 (male) / MicroRNAs / Middle Aged / Myocytes, Cardiac / Potassium Channels, Inwardly Rectifying / Potassium Channels, Voltage-Gated / Up-Regulation (徳島大学機関リポジトリ) ● Metadata: 118215 (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-15-1276 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27180889 ● Summary page in Scopus @ Elsevier: 2-s2.0-84969731123 (徳島大学機関リポジトリ: 118215, DOI: 10.1253/circj.CJ-15-1276, PubMed: 27180889, Elsevier: Scopus)

学術論文(紀要・その他):

1.	鈴木昭浩, 大塚邦紘, 髙成広起, 永松謙太郎, 白井昭博 : 次世代光による細胞光応答の解明, LED総合フォーラム 2020 in 徳島論文集, Vol.P-17, 105-106, 2020年.

総説・解説:

1.	納谷友希, 髙成広起 : 画像処理・画像解析による医療支援 ∼内視鏡と画像強調解析における画像センサの役割∼(1)(2), センサイトWEBジャーナル 2022年6月号, 2022年6月. (徳島大学機関リポジトリ) ● Metadata: 118293 (徳島大学機関リポジトリ: 118293)
2.	髙成広起, 加治佐平 : 医光融合研究の最先端, 月刊オプトロニクス, Vol.39, No.465, 111-116, 2020年9月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520854805366131456 (CiNii: 1520854805366131456)

国際会議:

1.	MIKU Matsumoto, Hiroki Takanari, Yasuo Minami and Shin-ichiro Yanagiya : In-situ observation of photo-induced phenomena of AuNP-deposited HeLa cells with femto second laser, Program of pLED International Symposium 2023: Exploring Invisible Light Technology, P-26, Mar. 2023.
2.	Y Kanemura, Hiroki Takanari and T Mizuno : Assessment of actin fibers in the cell using fluorescent polarization microscopy., Focus on Microscopy 2020 (poster presentation), Osaka, Apr. 2020.
3.	Hiroki Takanari, Y Hayashi, Eiji Hase, Takeo Minamikawa and Takeshi Yasui : Quantification of liver fibrosis by SHG microscopy., Focus on Microscopy 2020, Osaka, Apr. 2020.
4.	Eiji Hase, Hiroki Takanari, Mayuko Shimizu, Hayashi Yuri, Takeo Minamikawa, Takeshi Yasui and Koichi Tsuneyama : Characterization of fibrosis in non-alcoholic steatohepatitis by use of second-harmonic-generation microscopy, Asian Pacific Association for the Study of the Liver 2020 (APASL 2020), Bali, Indonesia, Mar. 2020.
5.	Takeo Minamikawa, Mayuko Shimizu, Hiroki Takanari, Shiomi Ryosuke, Kusaka Hiroki, Tanioka Hiroki, Eiji Hase, Takeshi Yasui and Koichi Tsuneyama : Molecular imaging analysis of accumulated fats in non-alcoholic steatohepatitis by Raman microscopy, Asian Pacific Association for the Study of the Liver 2020 (APASL 2020), Bali, Indonesia, Mar. 2020.

国内講演発表:

1.	松本実久, 柳谷伸一郎, 髙成広起, 南康夫 : フェムト秒レーザーによるHeLa細胞の細孔形成とナノ粒子の影響, 第43回レーザー学会年次大会, P01-20p-P-27-P01-20p-P-27], 2023年1月.
2.	谷口元基, 本田剛士, 柳谷伸一郎, 髙成広起, 南康夫, 中村信元, 三木浩和, 安倍正博, 坂東良美, 常山幸一 : ALアミロイドーシス無染色標本のラマン分光顕微観察, 2022年第83回応用物理学会秋季学術講演会, 20p-C301-12, 2022年9月. (キーワード) ラマン分光 / アミロイドーシス
3.	南川丈夫, 清水真祐子, 谷岡弘規, 長谷栄治, 森本友樹, 髙成広起, 安井武史, 常山幸一 : ラマン散乱分光法を用いた非アルコール性脂肪性肝疾患の脂質分子構造イメージング解析, レーザ顕微鏡研究会第46回講演会, 2021年11月.
4.	谷岡弘規, 南川丈夫, 清水真祐子, 森本友樹, 髙成広起, 大西湧太郎, 長谷栄治, 安井武史, 常山幸一 : 表面増強ラマン散乱分光法を用いた非アルコール性脂肪肝疾患モデルの高感度ラマンイメージング, 第82回応用物理学会秋季学術講演会予稿集, 13a-N202-9, 2021年9月.
5.	納谷友希, 髙成広起 : 血管強調画像観察に用いる光源の検証, 第98回日本生理学会・第126回日本解剖学会合同大会, 2021年3月.
6.	植田翠, 髙成広起, 常山幸一 : ラマン分光法による肺癌組織型の判別, 第98回日本生理学会・第126回日本解剖学会合同大会, 2021年3月.
7.	谷岡弘規, 南川丈夫, 清水真祐子, 森本友樹, 髙成広起, 塩見涼介, 長谷栄治, 安井武史, 常山幸一 : 非アルコール性脂肪性肝炎診断に対するラマン顕微鏡法の適用可能性の検証計, 第68回応用物理学会春季学術講演会予稿集, 19a-Z04-9, 2021年3月.
8.	楠本一真, 髙成広起, 田端厚之, 長宗秀明, 荒川幸弘, 南川慶二, 今田泰嗣, 八木下史敏 : D-π-A型ベンゾチアゾール誘導体の合成と光機能性, 2020年日本化学会中国四国支部大会島根大会, 2020年11月.
9.	納谷友希, 髙成広起 : Narrow Band Imaging (NBI) を用いた炎症部位の特定, 生体医工学シンポジウム2020, 2020年9月.
10.	楠本一真, 佐名川洋平, 長谷栄治, 髙成広起, 田端厚之, 長宗秀明, 荒川幸弘, 南川慶二, 今田泰嗣, 八木下史敏 : 多光子励起を目指したA-D-A型N-へテロアレーン類のデザインと応用, 2020年web光化学討論会, 2020年9月.
11.	梅林隆太, 岡本将輝, 長谷栄治, 髙成広起, 田端厚之, 長宗秀明, 荒川幸弘, 南川慶二, 今田泰嗣, 八木下史敏 : 多光子励起可能な水溶性イミダゾ[1,2-a]ピリジニウム塩の合成とミトコンドリアイメージング, 2020年web光化学討論会, 2020年9月.
12.	納谷友希, 髙成広起, 加治佐平 : 毛細血管の可視化を目指したNarrow Band Imaging(NBI)の光源特性の検証, 第81回日本応用物理学会秋季学術講演会, 2020年9月.
13.	Fumitoshi Yagishita, Junichi Tanigawa, Masaki Okamoto, Eiji Hase, Hiroki Takanari, Atsushi Tabata, Hideaki Nagamune, Takeo Minamikawa, Takeshi Yasui, Yasushi Imada and Yasuhiko Kawamura : Synthesis of Imidazopyridinium Salts Having Potential Application as Image-guided Photodynamic Therapy Agents, The 100th CSJ Annual Meeting, Mar. 2020.
14.	八木下史敏, 岡本将輝, 髙成広起, 長谷栄治, 田端厚之, 長宗秀明, 今田泰嗣, 安井武史, 河村保彦 : ミトコンドリアイメージングを可能とするイミダゾ[1,2-a]ピリジニウム塩の合成, 2019年日本化学会中国四国支部大会徳島大会, 2019年11月.
15.	八木下史敏, 谷川純一, 新居千穂, 田端厚之, 長宗秀明, 髙成広起, 今田泰嗣, 河村保彦 : 光線力学療法への応用を狙いとしたイミダゾ[1,5-a]ピリジニウム塩の合成, 2019年日本化学会中国四国支部大会徳島大会, 2019年11月.
16.	八木下史敏, 梅林隆太, 岡本将輝, 田端厚之, 長宗秀明, 髙成広起, 今田泰嗣, 河村保彦 : D-π-A 型イミダゾ [1,2-a] ピリジニウム塩の合成とミトコンドリアイメージングへの応用, 2019年光化学討論会, 2019年9月.
17.	山口堅三, 長谷栄治, 金村洋平, 髙成広起, 岡本敏弘, 原口雅宣, 安井武史 : 金ナノ粒子を用いたバイオイメージングにおけるコントラストの増強, 生体医工学シンポジウム2019, 2A-30, 2019年9月.

その他・研究会:

1.	谷岡弘規, 南川丈夫, 清水真祐子, 森本友樹, 髙成広起, 塩見涼介, 長谷栄治, 安井武史, 常山幸一 : 非アルコール性脂肪肝炎の蓄積した脂肪に着目したラマン分光イメージング, LED総合フォーラム2021 in 徳島, P-14, 2021年2月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

光誘起現象を制御した複合ナノ結晶材料の設計と医光応用 (研究課題/領域番号: 22K04713 )
デュアルコム分光法を応用した細胞膜電位の非接触・非標識測定技術の新規開発 (研究課題/領域番号: 21K19913 )
miRNA発現パターンと病理所見に基づく機械学習による冠動脈硬化症のクラスター化 (研究課題/領域番号: 21K10533 )
ラマン分光法を用いたALアミロイドーシスに対する迅速診断法の新規開発 (研究課題/領域番号: 20K08712 )
生体光センシング技術への応用を目指した磁気共鳴ラマン分光法の新規研究開発 (研究課題/領域番号: 19H04443 )
アルコール脱水素酵素の臓器障害発症への関与 (研究課題/領域番号: 19H04038 )
ダウン症候群の核型正常化による合併症の予防および治療法確立に向けた研究 (研究課題/領域番号: 16K09964 )
心肺蘇生時の胸部圧迫に伴う心嚢破裂発生機序の解明 (研究課題/領域番号: 16K09222 )
ラマン散乱光分析とインピーダンス測定を組み合わせた新しい組織診断技術の開発 (研究課題/領域番号: 16H05238 )
コケイン症候群における転写調節異常と神経細胞の分化・維持機構への影響 (研究課題/領域番号: 15K06758 )
不全心における胎生期遺伝子再発現が心筋ギャップ結合の発現・分布・機能に及ぼす影響 (研究課題/領域番号: 26860215 )
成熟心筋を細胞周期に再入させることによる心筋再生の基礎的研究 (研究課題/領域番号: 26670189 )
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髙成 広起

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髙成広起