Tokushima University / Educator and Researcher Directory --- Kanai, Mai

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Tokushima University > Graduate School of Biomedical Sciences > 保健科学域 > Health Science > Biomedical Laboratory Sciences > Department of Pathological Science and Technology >
Tokushima University > Faculty of Medicine > School of Health Sciences > Major in Laboratory Science > Morphological Laboratory Science >

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Academic Paper (Judged Full Paper):

1.	Dong Bingzi, Itsuro Endo, Ohnishi Yukoyo, Mitsui Yukari, Kiyoe Kurahashi, Mai Kanai, Masahiro Hiasa, Jumpei Teramachi, Hirofumi Tenshin, Seiji Fukumoto, Masahiro Abe and Toshio Matsumoto : Persistent Activation of Calcium-Sensing Receptor Suppresses Bone Turnover, Increases Microcracks, and Decreases Bone Strength., JBMR Plus, Vol.3, No.7, e10182, 2019. (Summary) Activating mutations of calcium-sensing receptor (CaSR) cause autosomal dominant hypocalcemia type 1 (ADH1). Patients with ADH1 exhibit similar features to patients with hypoparathyroidism, including reduced serum parathyroid hormone (PTH) and Ca with low bone turnover. Although persistent suppression of bone turnover may increase bone fragility, bone strength in ADH1 patients has been unclear. We created knock-in mice harboring the A843E activating mutation of CaSR, mimicking severe features of ADH1 patients. The severe form of ADH1 model mice showed smaller body and bone size with lower bone mineral density (BMD) and cortical area of the femur compared with age-matched wild-type (WT) mice. Bone strength in the femur was lower in ADH1 mice even after correction by bone geometry and/or BMD. Microcracks were markedly increased in ADH1 mice, but were rarely detected in WT mice. There was a negative correlation between bone strength corrected by bone geometry and/or BMD and microcrack number or density in ADH1 and WT mice. Among ADH1 mice, negative correlation was still observed between bone strength and microcrack number or density. Microcracks increased with age in ADH1 mice, and were negatively correlated with bone strength. Treatment with PTH(1-34) or a calcilytic, JTT-305, increased bone turnover, reduced microcracks, and increased bone strength to similar levels to those in WT mice. The increase in microcracks was associated with a reduction in bone strength in ADH1 mice, and aging aggravates these changes. These results demonstrate that activating mutation of CaSR causes reduction in PTH secretion with suppressed bone turnover, that reduced bone turnover is associated with an age-dependent increase in microcracks with a reduction in bone strength, and that both PTH(1-34) and calcilytic ameliorate all these changes in bone turnover and strength. It is suggested that fracture susceptibility may be increased in severe types of ADH1 patients especially in the elderly. © 2019 The Authors. published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research. (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm4.10182 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31372589 ● Search Scopus @ Elsevier (PMID): 31372589 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm4.10182 (DOI: 10.1002/jbm4.10182, PubMed: 31372589)

Proceeding of International Conference:

1.	Mai Kanai, Itsuro Endo, Yasuko Takahashi, Jumpei Teramachi, Hirofumi Tenshin, Masahiro Hiasa, Seiji Fukumoto, Masahiro Abe and Toshio Matsumoto : Establishment of model mice of FGF23-related hypophosphatemia induced by iron solution administration, ASBMR 2019, Orlando, Sep. 2019.

Proceeding of Domestic Conference:

1.	Mai Kanai, 松岡飛翔, Itsuro Endo, 大西幸代, Yuichi Takashi, Kiyoe Kurahashi, Sumiko Yoshida, Ken-ichi Aihara, Masahiro Abe, Seiji Fukumoto and Toshio Matsumoto : 鉄製剤投与によるFGF23関連低リン血症モデル作成の試み, 日本内分泌学会雑誌, Vol.95, No.1, 422, May 2019.
2.	木村優里, 高橋寛典, 松島滉海, Akiko Sakurai, Mai Kanai and Itsuro Endo : TAK1阻害による炎症性サイトカイン誘導性サルコペ二ア改善の可能性, 第42回徳島県医学検査学会, Dec. 2018.
3.	松島滉海, 木村優里, 高橋寛典, Akiko Sakurai, Mai Kanai, Takeshi Kondo, 桝田志保, Tomoteru Kishimoto and Itsuro Endo : hCG, FSH製剤の併用によりパートナーの妊娠，健常児正常出産が確認された低ゴナドトロピン性男背性性腺機能低下症の2例, 第42回徳島県医学検査学会, Dec. 2018.
4.	挂江阿子, 西川真由, Jin Furuike, Mai Kanai and Noriko Kagawa : 腎盂に発生した肉腫様がんの一例, 第41回徳島県臨床検査技師会, Dec. 2017.
5.	古池仁, 挂江阿子, 西川真由, Mai Kanai and Noriko Kagawa : 拡張型心筋症の病理学的検討-2 ー全周性切り出しによるー, 第41回徳島県臨床検査技師会, Dec. 2017.
6.	西川真由, 掛江阿子, 古池仁, Mai Kanai and Noriko Kagawa : 拡張型心筋症の病理学的検討-1 ー介在板間の測定ー, 第41回徳島県臨床検査技師会, Dec. 2017.
7.	岡諭紀, Mai Kanai, Akiko Sakurai and Itsuro Endo : 免疫チェックポイント阻害薬で中枢性副腎不全を来した2例, 第41回徳島県医学検査学会, Dec. 2017.
8.	野原圭一郎, 岡諭紀, 藤田幸那, Mai Kanai, Akiko Sakurai and Itsuro Endo : デノスマブによる対糖能改善, 第41回徳島県医学検査学会, Dec. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

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