Tokushima University / Educator and Researcher Directory --- Fujii, Hideki

Field of Study

○	Immunology

Subject of Study

○

Book / Paper

Book:

1.	Hiromichi Yumoto, Katsuhiko Hirota, Kouji Hirao, Masami Ninomiya, Keiji Murakami, Hideki Fujii and Yoichiro Miyake : The Pathogenic Factors from Oral Streptococci for Systemic Diseases, Aug. 2020.

Academic Paper (Judged Full Paper):

1.	Adityakrisna Putra Yoshi Wigianto, Yuichi Ishida, Yuki Iwawaki, Takaharu Goto, Megumi Watanabe, Kazumitsu Sekine, Kenichi Hamada, Keiji Murakami, Hideki Fujii and Tetsuo Ichikawa : 2-methacryloyloxyethyl phosphorylcholine polymer treatment prevents Candida albicans biofilm formation on acrylic resin, Journal of Prosthodontic Research, Vol.67, No.3, 384-391, 2022. (Summary) We aimed to evaluate the effectiveness of photoreactive 2-methacryloyloxyethyl phosphorylcholine (MPC) in inhibiting Candida albicans biofilm formation on polymethyl methacrylate (PMMA) and assess its mechanism and need for re-application by evaluating its interaction with salivary mucin and durability during temperature changes. PMMA discs were used as specimens. The MPC coating was applied using the spray and cure technique for the treatment groups, whereas no coating was applied to the control. The MPC treatment (MT) groups were further differentiated based on the number of thermal cycles involved (0, 1000, 2500, and 5000). The optical density was measured to assess mucin adsorption (MA). Contact angle (CA) was calculated to evaluate surface hydrophilicity. The presence of MPC components on the PMMA surface was assessed using X-ray photoelectron spectroscopy (XPS). C. albicans biofilms were evaluated qualitatively (scanning electron microscope images) and quantitatively (colony-forming units (CFUs)). Statistical analysis was conducted using two-way analysis of variance and Tukey's multiple comparison test. MA rate and CA increased significantly in the MT groups, which exhibited significantly fewer CFUs and thinner biofilms than those of the control group. Based on the XPS, MA, and CFU evaluations, the durability and efficacy of the MPC coating were considered stable up to 2500 thermal cycles. Additionally, a significant interaction was observed between mucin concentration and MPC efficacy. The photoreactive MPC coating, which was resistant to temperature changes for approximately 3 months, effectively prevented C. albicans biofilm formation by modifying surface hydrophilicity and increasing mucin adsorption. (Keyword) Candida albicans / Acrylic Resins / Polymers / Polymethyl Methacrylate / Surface Properties / Biofilms / Mucins (Tokushima University Institutional Repository) ● Metadata: 119402 (Link to Publication Site) ● Publication site (DOI): 10.2186/jpr.JPR_D_22_00102 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36288959 ● Summary page in Scopus @ Elsevier: 2-s2.0-85166383313 (Tokushima University Institutional Repository: 119402, DOI: 10.2186/jpr.JPR_D_22_00102, PubMed: 36288959, Elsevier: Scopus)
2.	Yuta Uemura, Yuka Hiroshima, Ayano Tada, Keiji Murakami, Kaya Yoshida, Yuji Inagaki, Tomomi Kuwahara, Akikazu Murakami, Hideki Fujii and Hiromichi Yumoto : Porphyromonas gingivalis Outer Membrane Vesicles Stimulate Gingival Epithelial Cells to Induce Pro-Inflammatory Cytokines via the MAPK and STING Pathways, Biomedicines, Vol.10, No.10, 2643, 2022. (Summary) () is a keystone pathogen associated with chronic periodontitis and produces outer membrane vesicles (OMVs) that contain lipopolysaccharide (LPS), gingipains, and pathogen-derived DNA and RNA. -OMVs are involved in the pathogenesis of periodontitis. -OMV-activated pathways that induce the production of the pro-inflammatory cytokines, interleukin (IL)-6, and IL-8 in the human gingival epithelial cell line, OBA-9, were investigated. The role of mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB in levels of -OMV-induced pro-inflammatory cytokines was investigated using Western blot analysis and specific pathway inhibitors. -OMVs induced IL-6 and IL-8 production via the extracellular signal-regulated kinase (Erk) 1/2, c-Jun N-terminal kinase (JNK), p38 MAPK, and NF-κB signaling pathways in OBA-9 cells. In addition, the stimulator of interferon genes (STING), an essential innate immune signaling molecule, was triggered by a cytosolic pathogen DNA. -OMV-induced IL-6 and IL-8 mRNA expression and production were significantly suppressed by STING-specific small interfering RNA. Taken together, these results demonstrated that -OMV-activated Erk1/2, JNK, p38 MAPK, STING, and NF-κB signaling pathways resulting in increased IL-6 and IL-8 expression in human gingival epithelial cells. These results suggest that -OMVs may play important roles in periodontitis exacerbation by stimulating various pathways. (Tokushima University Institutional Repository) ● Metadata: 117616 (Link to Publication Site) ● Publication site (DOI): 10.3390/biomedicines10102643 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36289904 ● Search Scopus @ Elsevier (PMID): 36289904 ● Search Scopus @ Elsevier (DOI): 10.3390/biomedicines10102643 (Tokushima University Institutional Repository: 117616, DOI: 10.3390/biomedicines10102643, PubMed: 36289904)
3.	Naoto Okada, Akikazu Murakami, Masami Satou, Shingen Nakamura, Shiroh Fujii, Kimiko Sogabe, Mamiko Takahashi, Asami Okada, Akane Abe, Hideki Fujii, Masahiro Abe, Momoyo Azuma and Keisuke Ishizawa : First reported case of Lachnoanaerobaculum gingivalis bacteremia in an acute myeloid leukemia patient with oral mucositis during high dose chemotherapy., Anaerobe, Vol.76, 2022. (Summary) During chemotherapy in patients with oral mucositis, we should consider the possibility of L. gingivalis bacteremia. (Link to Publication Site) ● Publication site (DOI): 10.1016/j.anaerobe.2022.102610 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35811059 ● Search Scopus @ Elsevier (PMID): 35811059 ● Search Scopus @ Elsevier (DOI): 10.1016/j.anaerobe.2022.102610 (DOI: 10.1016/j.anaerobe.2022.102610, PubMed: 35811059)
4.	Muhammad Reza Pahlevi, Keiji Murakami, Yuka Hiroshima, Akikazu Murakami and Hideki Fujii : pruR and PA0065 Genes Are Responsible for Decreasing Antibiotic Tolerance by Autoinducer Analog-1 (AIA-1) in Pseudomonas aeruginosa, Antibiotics, Vol.11, No.6, 773, 2022. (Tokushima University Institutional Repository) ● Metadata: 117279 (Link to Publication Site) ● Publication site (DOI): 10.3390/antibiotics11060773 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35740179 ● Search Scopus @ Elsevier (PMID): 35740179 ● Search Scopus @ Elsevier (DOI): 10.3390/antibiotics11060773 (Tokushima University Institutional Repository: 117279, DOI: 10.3390/antibiotics11060773, PubMed: 35740179)
5.	Mizuki Abe, Keiji Murakami, Yuka Hiroshima, Takashi Amoh, Mayu Sebe, Keiko Kataoka and Hideki Fujii : Autoinducer Analogs Can Provide Bactericidal Activity to Macrolides in Pseudomonas aeruginosa through Antibiotic Tolerance Reduction, Antibiotics, Vol.11, No.1, 2021. (Summary) Macrolide antibiotics are used in treating chronic biofilm infections despite their unsatisfactory antibacterial activity, because they display several special activities, such as modulation of the bacterial quorum sensing and immunomodulatory effects on the host. In this study, we investigated the effects of the newly synthesized quorum-sensing autoinducer analogs (AIA-1, -2) on the activity of azithromycin and clarithromycin against . In the killing assay of planktonic cells, AIA-1 and -2 enhanced the bactericidal ability of macrolides against PAO1; however, they did not affect the minimum inhibitory concentrations of macrolides. In addition, AIA-1 and -2 considerably improved the killing activity of azithromycin and clarithromycin in biofilm cells. The results indicated that AIA-1 and -2 could affect antibiotic tolerance. Moreover, the results of hydrocarbon adherence and cell membrane permeability assays suggested that AIA-1 and -2 changed bacterial cell surface hydrophobicity and accelerated the outer membrane permeability of the hydrophobic antibiotics such as azithromycin and clarithromycin. Our study demonstrated that the new combination therapy of macrolides and AIA-1 and -2 may improve the therapeutic efficacy of macrolides in the treatment of chronic biofilm infections. (Tokushima University Institutional Repository) ● Metadata: 117210 (Link to Publication Site) ● Publication site (DOI): 10.3390/antibiotics11010010 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35052885 ● Summary page in Scopus @ Elsevier: 2-s2.0-85121669540 (Tokushima University Institutional Repository: 117210, DOI: 10.3390/antibiotics11010010, PubMed: 35052885, Elsevier: Scopus)
6.	Momoyo Azuma, Keiji Murakami, Rina Murata, Keiko Kataoka, Hideki Fujii, Yoichiro Miyake and Yasuhiko Nishioka : Clinical Significance of Carbapenem-Tolerant Pseudomonas aeruginosa Isolated in the Respiratory Tract, Antibiotics, Vol.9, No.9, 2020. (Summary) infections. (Tokushima University Institutional Repository) ● Metadata: 116480 (Link to Publication Site) ● Publication site (DOI): 10.3390/antibiotics9090626 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32967210 ● Search Scopus @ Elsevier (PMID): 32967210 ● Search Scopus @ Elsevier (DOI): 10.3390/antibiotics9090626 (Tokushima University Institutional Repository: 116480, DOI: 10.3390/antibiotics9090626, PubMed: 32967210)
7.	Natsumi Fujiwara, Keiji Murakami, Kaya Yoshida, Shunsuke Sakurai, Yasusei Kudo, Kazumi Ozaki, Katsuhiko Hirota, Hideki Fujii, Maiko Suzuki, Yoichiro Miyake and Hiromichi Yumoto : Suppresive effects of 2-methacryloyloxyethyl phosphorylcholine (MPC)-polymer on the adherence of Candida species and MRSA to acrylic denture resin., Heliyon, Vol.6, e04211, 2020. (Tokushima University Institutional Repository) ● Metadata: 115916 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.heliyon.2020.e04211 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32577575 ● Summary page in Scopus @ Elsevier: 2-s2.0-85086425832 (Tokushima University Institutional Repository: 115916, DOI: 10.1016/j.heliyon.2020.e04211, PubMed: 32577575, Elsevier: Scopus)
8.	Hiromichi Yumoto, Katsuhiko Hirota, Kouji Hirao, Masami Ninomiya, Keiji Murakami, Hideki Fujii and Yoichiro Miyake : The pathogenic factors from oral Streptococci for systemic diseases, International Journal of Molecular Sciences, Vol.20, No.18, 2019. (Tokushima University Institutional Repository) ● Metadata: 114574 (Link to Publication Site) ● Publication site (DOI): 10.3390/ijms20184571 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85072542634 (Tokushima University Institutional Repository: 114574, DOI: 10.3390/ijms20184571, Elsevier: Scopus)
9.	Ho Namkoong, Makoto Ishii, Hideki Fujii, Kazuma Yagi, Takahiro Asami, Takanori Asakura, Shoji Suzuki, Ahmed E. Hegab, Hirofumi Kamata, Sadatomo Tasaka, Koji Atarashi, Nobuhiro Nakamoto, Satoshi Iwata, Kenya Honda, Takanori Kanai, Naoki Hasegawa, Shigeo Koyasu and Tomoko Betsuyaku : Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia, PLoS Pathogens, Vol.14, No.4, e1006955, 2018. (Summary) Macrolides are used to treat various inflammatory diseases owing to their immunomodulatory properties; however, little is known about their precise mechanism of action. In this study, we investigated the functional significance of the expansion of myeloid-derived suppressor cell (MDSC)-like CD11b+Gr-1+ cells in response to the macrolide antibiotic clarithromycin (CAM) in mouse models of shock and post-influenza pneumococcal pneumonia as well as in humans. Intraperitoneal administration of CAM markedly expanded splenic and lung CD11b+Gr-1+ cell populations in naïve mice. Notably, CAM pretreatment enhanced survival in a mouse model of lipopolysaccharide (LPS)-induced shock. In addition, adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice against LPS-induced lethality via increased IL-10 expression. CAM also improved survival in post-influenza, CAM-resistant pneumococcal pneumonia, with improved lung pathology as well as decreased interferon (IFN)-γ and increased IL-10 levels. Adoptive transfer of CAM-treated CD11b+Gr-1+ cells protected mice from post-influenza pneumococcal pneumonia. Further analysis revealed that the CAM-induced CD11b+Gr-1+ cell expansion was dependent on STAT3-mediated Bv8 production and may be facilitated by the presence of gut commensal microbiota. Lastly, an analysis of peripheral blood obtained from healthy volunteers following oral CAM administration showed a trend toward the expansion of human MDSC-like cells (Lineage-HLA-DR-CD11b+CD33+) with increased arginase 1 mRNA expression. Thus, CAM promoted the expansion of a unique population of immunosuppressive CD11b+Gr-1+ cells essential for the immunomodulatory properties of macrolides. (Keyword) Animals / Anti-Bacterial Agents / CD11b Antigen / Cell Differentiation / Cell Proliferation / Clarithromycin / Gastrointestinal Hormones / Lipopolysaccharides / Male / Mice / Mice, Inbred C57BL / Myeloid Cells / Neuropeptides / Orthomyxoviridae / Orthomyxoviridae Infections / Phagocytosis / Pneumonia, Pneumococcal / STAT3 Transcription Factor / Shock, Septic / Streptococcus pneumoniae (Tokushima University Institutional Repository) ● Metadata: 114326 (Link to Publication Site) ● Publication site (DOI): 10.1371/journal.ppat.1006955 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29621339 ● Summary page in Scopus @ Elsevier: 2-s2.0-85046456194 (Tokushima University Institutional Repository: 114326, DOI: 10.1371/journal.ppat.1006955, PubMed: 29621339, Elsevier: Scopus)
10.	Sekita Yasuko, Keiji Murakami, Hiromichi Yumoto, Kouji Hirao, Takashi Amoh, Natsumi Fujiwara, Katsuhiko Hirota, Hideki Fujii, Takashi Matsuo, Yoichiro Miyake and Yoshiki Kashiwada : Antibiofilm and Anti-Inflammatory Activities of+ Houttuynia cordata Decoction for Oral Care, Evidence-Based Complementary and Alternative Medicine : eCAM, Vol.2017, 2850947, 2017. (Summary) Dental biofilms that form in the oral cavity play a critical role in the pathogenesis of several infectious oral diseases, including dental caries, periodontal disease, and oral candidiasis. (HC, Saururaceae) is a widely used traditional medicine, for both internal and external application. A decoction of dried HC leaves (dHC) has long been consumed as a health-promoting herbal tea in Japan. We have recently reported that a water solution of HC poultice ethanol extract (wHCP) exerts antimicrobial and antibiofilm effects against several important oral pathogens. It also exhibits anti-inflammatory effects on human keratinocytes. In our current study, we examined the effects of dHC on infectious oral pathogens and inflammation. Our results demonstrated that dHC exerts moderate antimicrobial effects against methicillin-resistant (MRSA) and other oral microorganisms. dHC also exhibited antibiofilm effects against MRSA, (involved in dental plaque formation), and and inhibitory effects on interleukin-8, CCL20, IP-10, and GRO productions by human oral keratinocytes stimulated by lipopolysaccharide (a cause of periodontal disease), without cytotoxic effects. This suggests that dHC exhibits multiple activities in microorganisms and host cells. dHC can be easily prepared and may be effective in preventing infectious oral diseases. (Tokushima University Institutional Repository) ● Metadata: 112956 (Link to Publication Site) ● Publication site (DOI): 10.1155/2017/2850947 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29234378 ● Summary page in Scopus @ Elsevier: 2-s2.0-85042323475 (Tokushima University Institutional Repository: 112956, DOI: 10.1155/2017/2850947, PubMed: 29234378, Elsevier: Scopus)

Review, Commentary:

1.	Hiromichi Yumoto, Katsuhiko Hirota, Yoichiro Miyake, Keiji Murakami, Natsumi Fujiwara, 秋月皆人 and Hideki Fujii : ``撥菌''∼口腔バイオフィルム感染症予防への応用∼, The Journal of Educational Conference on All Japan Colleges of Dental Hygiene, Vol.10, No.25, 13-17, Mar. 2021. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1521980706066501120 (CiNii: 1521980706066501120)
2.	Keiji Murakami and Hideki Fujii : Risk of cross-infection of drug-resistant bacteria in dental practice, Journal of Oral Health and Biosciences, Vol.30, No.2, 67-68, Feb. 2018. (Tokushima University Institutional Repository) ● Metadata: 111072 (Link to Publication Site) ● Publication site (DOI): 10.20738/johb.30.2_67 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.20738/johb.30.2_67 (Tokushima University Institutional Repository: 111072, DOI: 10.20738/johb.30.2_67)

Proceeding of International Conference:

1.	Yuetsu Tanaka, Yoshiaki Takahashi, Hideki Fujii, Reiko Tanaka, Takuya Fukushima and Mineki Saito : High Levels of Soluble OX40 in Plasma Are Associated with Acute ATL, 18th International Conference on Human Retrovirology, Mar. 2017. (Keyword) HTLV-1 / OX40 / OX40L / CD25
2.	Hideki Fujii, Yoshihiro Hayakawa, Yoshiaki Takahashi, Reiko Tanaka, Ikuo Saiki, Takuya Fukushima and Yuetsu Tanaka : Herbal Medicine Regulate HTLV-1 Provirus Activation, 18th International Conference on Human Retrovirology, Mar. 2017. (Keyword) HTLV-1 / Herbal Medicine

Proceeding of Domestic Conference:

1.	Muhammad Reza Pahlevi, Keiji Murakami, Murata Rina and Hideki Fujii : Identification of antibiotic tolerance related genes to AIA-1 in Pseudomonas aeruginosa, 93,
2.	SATOH Tomomi, Yuka Hiroshima, Akikazu Murakami, Hideki Fujii, Akiko Sakurai, Keiko Kataoka and Keiji Murakami : カタラーゼをコードするkatA/katB遺伝子が及ぼす緑膿菌の抗菌薬抵抗性における影響, 第45回徳島県医学検査学会, Dec. 2021.
3.	Yuta Uemura, Yuka Hiroshima, 村上圭史, Yuji Inagaki, Hideki Fujii and Hiromichi Yumoto : Porphyromonas gingivalis OMVによる歯肉上皮細胞のサイトカイン産生機構, 四国歯学会第58回例会, Nov. 2021.
4.	秋月皆人, 植村勇太, Keiji Murakami, Yuka Hiroshima, Hideki Fujii and Hiromichi Yumoto : 歯周病原細菌とその線毛TypeのPCRによる迅速検出システムの有効性の検討, 第74回日本細菌学会中国・四国支部総会, Oct. 2021.
5.	Yuta Uemura, Yuka Hiroshima, Keiji Murakami, 多田彩乃, Tomomi Kuwahara, Hideki Fujii and Hiromichi Yumoto : Porphyromonas gingivalis OMVによる歯肉上皮細胞のサイトカイン産生機構, 第74回日本細菌学会中国・四国支部総会, Oct. 2021.
6.	Yuta Uemura, Yuka Hiroshima, Keiji Murakami, Yuji Inagaki, Hiromichi Yumoto and Hideki Fujii : ヒト歯肉上皮細胞におけるPorphyromonas gingivalis由来メンブレンベシクルの炎症性サイトカイン産生誘導機構の解明, 第19回四国免疫フォーラム, Jun. 2021.
7.	Yuta Uemura, Yuka Hiroshima, Keiji Murakami, 多田彩乃, Tomomi Kuwahara, Hideki Fujii and Hiromichi Yumoto : Porphyromonas gingivalis由来メンブレンベシクルがヒト歯肉上皮細胞に及ぼす影響, 第73回日本細菌学会中国・四国支部総会, 32, Oct. 2020.
8.	Pahlevi Reza Muhammad, Keiji Murakami, Yuta Kita, Rina Murata, Yuka Hiroshima and Hideki Fujii : Screening for the genes influenced by AIA-1 in Pseudomonas aeruginosa, 第73回日本細菌学会中国・四国支部総会, 31, Oct. 2020.
9.	AKIZUKI Minato, Keiji Murakami, Yuka Hiroshima, Hideki Fujii and Hiromichi Yumoto : MPCポリマーコーティングにおけるTi表面への歯周病原菌付着抑制効果の検討, 第73回日本細菌学会中国・四国支部総会, 30, Oct. 2020.
10.	Yuta Kita, Pahlevi Reza Muhammad, Rina Murata, Keiji Murakami, Yuka Hiroshima and Hideki Fujii : バイオフィルム形成緑膿菌におけるPA2384遺伝子の役割について, 第73回日本細菌学会中国・四国支部総会, 29, Oct. 2020.
11.	Rina Murata, Keiji Murakami, Yuka Hiroshima, Koichiro Tsuchiya, Keiko Kataoka and Hideki Fujii : 緑膿菌における抗菌薬添加によるスーパーオキシドの発生について, 第73回日本細菌学中国・四国支部総会, 22, Oct. 2020.
12.	Muhammad Reza Pahlevi, Keiji Murakami and Hideki Fujii : Screening for antibiotic tolerance factor of Pseudomonas aeruginosa, 第62回歯科基礎医学会学術大会, Sep. 2020.
13.	Keiji Murakami, 村田梨菜, Koichiro Tsuchiya, Keiko Kataoka and Hideki Fujii : 緑膿菌における抗菌薬添加による酸化ストレスについて, 第54回緑膿菌感染症研究会, Feb. 2020.
14.	Keiji Murakami and Hideki Fujii : 緑膿菌におけるc-di-GMPによるバイオフィルム形成の制御, 第93回日本細菌学会総会, Feb. 2020.
15.	村田梨菜, Keiji Murakami, Yuka Hiroshima, Keiko Kataoka and Hideki Fujii : 緑膿菌における抗菌薬添加による酸化ストレス反応について, 第93回日本細菌学会総会, Feb. 2020.
16.	岡本舞, Yuta Kita, Rina Murata, Pahlevi Reza Muhammad, Keiji Murakami, Yuka Hiroshima, Keiko Kataoka and Hideki Fujii : 緑膿菌におけるバイオフィルム形成菌の抗菌薬抵抗性について, 徳島県歯科医学大会, Feb. 2020.
17.	Rina Murata, Pahlevi Reza Muhammad, Keiji Murakami, Yuka Hiroshima, Keiko Kataoka and Hideki Fujii : 緑膿菌における抗菌薬添加と酸化ストレスについて, 徳島県歯科医学大会, Feb. 2020.
18.	喜田悠太, Keiji Murakami, Yuka Hiroshima and Hideki Fujii : 緑膿菌におけるバイオフィルム形成菌の抗菌薬抵抗性に関わる遺伝子について, 第72回日本細菌学会中国・四国支部総会, Nov. 2019.
19.	藤本望, 村田梨菜, Keiji Murakami, Yuka Hiroshima, Keiko Kataoka and Hideki Fujii : 亜硝酸イオンの口腔内における生理的意義について, 第72回日本細菌学会中国・四国支部総会, Nov. 2019.
20.	村田梨菜, 藤本望, Keiji Murakami, Yuka Hiroshima, Keiko Kataoka and Hideki Fujii : 緑膿菌における抗菌薬添加と酸化ストレスについて, 第72回日本細菌学会中国・四国支部総会, Nov. 2019.
21.	Keiji Murakami, 喜田悠太, 村田梨菜, Yuka Hiroshima, Keiko Kataoka and Hideki Fujii : 緑膿菌バイオフィルム形成菌の抗菌薬抵抗性に関わる遺伝子について, 第33回日本バイオフィルム学会学術集会, Jul. 2019.
22.	Keiji Murakami, 天羽崇, Keiko Kataoka and Hideki Fujii : The correlation between antibiotic tolerance and antioxidant ability in Pseudomonas aeruginosa, The 92nd Annual Meeting of Japanese Society for Bacteriology, Apr. 2019.
23.	藤本望, 村田梨菜, Keiji Murakami, Hideki Fujii, Licht Miyamoto, 井上貴久, Koichiro Tsuchiya, Yasumasa Ikeda, Yuki Izawa-Ishizawa and Shuichi Hamano : 唾液中の硝酸イオンが口腔細菌に与える影響について·, 第42回徳島県医学検査学会, Dec. 2018.
24.	Rina Murata, Keiji Murakami, Hideki Fujii, 佐藤雅美, 笹田倫子, 井上みなみ, 平尾早紀, 別所将弘, Momoyo Azuma, Akiko Sakurai and Keiko Kataoka : 呼吸器感染症患者由来緑膿菌の抗菌薬抵抗性と抗酸化能の関連について, 第42回徳島県医学検査学会, Dec. 2018.
25.	Natsumi Fujiwara, Keiji Murakami, Kaya Yoshida, Yasusei Kudo, Katsuhiko Hirota, Kazumi Ozaki, Hideki Fujii and Hiromichi Yumoto : MPCポリマーコーティングによる義歯用レジンのカンジダ付着(撥菌)効果, 第60回日本歯科基礎医学会学術大会 2018年9月5-7日(九州大学病院キャンパス百年講堂, 福岡市), Sep. 2018.
26.	Takashi Amoh, Keiji Murakami, 狩山玲子, Katsuhiko Hirota, 公文裕巳, Yoichiro Miyake and Hideki Fujii : 浮遊菌とバイオフィルム形成菌の抗菌薬抵抗性に対するrpoS遺伝子の役割, 第32回日本バイオフィルム学会学術集会, Jul. 2018.
27.	Keiji Murakami, Takashi Amoh, Keiko Kataoka, 狩山玲子, Katsuhiko Hirota, Yoichiro Miyake and Hideki Fujii : 緑膿菌オートインデューサーアナログのマクロライドに対する効果, 第91回日本細菌学会総会, Mar. 2018.
28.	Takashi Amoh, Keiji Murakami, 狩山玲子, Katsuhiko Hirota, Yoichiro Miyake and Hideki Fujii : 緑膿菌rpoS遺伝子が抗菌薬抵抗性に及ぼす役割, 第91回日本細菌学会総会, Mar. 2018.
29.	谷脇竜弥, 杉田知世, Keiji Murakami, Takashi Amoh, Atsushi Tabata, Yoshiko Yamamura, Tetsuya Tamatani, Hideaki Nagamune, Youji Miyamoto and Hideki Fujii : 幼児口腔内創部より検出された多剤耐性レンサ球菌について, 四国歯学会第52回例会, Mar. 2018.
30.	Hideki Fujii : 成人T細胞白血病 (ATL) の新たなバイオマーカー:TNF受容体スーパーファミリー分子OX40, 2017年度生命科学系学会合同年次大会(ConBio2017), Dec. 2017. (Keyword) OX40 / OX40L / CD25 / HTLV-1 / ATL
31.	Takashi Amoh, Keiji Murakami, 狩山玲子, Katsuhiko Hirota, Yoichiro Miyake and Hideki Fujii : rpoS遺伝子が緑膿菌の抗菌薬抵抗性に及ぼす影響, 第70回日本細菌学会中国・四国支部総会, Oct. 2017.
32.	田中礼子, 高橋良明, Hideki Fujii, 福島卓也, 立松健司, 黒田俊一 and 田中勇悦 : 全自動1細胞解析単離装置とEBVを用いたHTLV-1感染防御ヒト抗体の作出の試み, 第4回日本HTLV-1学会学術集会, Aug. 2017. (Keyword) HTLV-1 / EBV / 全自動1細胞解析管理装置
33.	田中勇悦, 高橋良明, Hideki Fujii, 田中礼子 and 福島卓也 : 活性化ビタミンD3によるHTLV-a Tax発現と感染性制御, 第4回日本HTLV-1学会学術集会, Aug. 2017. (Keyword) HTLV-1 / ビタミンD3
34.	Hideki Fujii, 早川芳弘, 高橋良明, 田中礼子 and 田中勇悦 : 漢方方剤併用による抗HTLV-1中和単クロン抗体のHTLV-1感染細胞排除効果の増強, 第4回日本HTLV-1学会学術集会, Aug. 2017. (Keyword) HTLV-1 / 漢方

Et cetera, Workshop:

1.	立山実弥, 田端千歳, Akikazu Murakami and Hideki Fujii : 口腔細菌に対する天然バクテリオファージの単離技術の最適化, Shikoku Dental Research,
2.	Saho Yamanaka, Rina Murata, Keiji Murakami, Yuka Hiroshima, Hideki Fujii, Akiko Sakurai and Keiko Kataoka : 緑膿菌の抗菌薬抵抗性に関与する二成分制御系について, 第44回徳島県医学検査学会, Dec. 2020.
3.	Yuta Uemura, Yuka Hiroshima, Keiji Murakami, 多田彩乃, Tomomi Kuwahara, Hideki Fujii and Hiromichi Yumoto : Porphyromonas gingivalis由来メンブレンベシクルがヒト歯肉上皮細胞に及ぼす影響, 徳島大学研究クラスター Joint Meeting on Microbiology 2020, Nov. 2020.
4.	Pahlevi Reza Muhammad, Keiji Murakami, Yuta Kita, Rina Murata, Yuka Hiroshima and Hideki Fujii : Screening for the genes influenced by AIA-1 in Pseudomonas aeruginosa, 徳島大学研究クラスター Joint Meeting on Microbiology 2020, Nov. 2020.
5.	AKIZUKI Minato, Keiji Murakami, Yuka Hiroshima, Hideki Fujii and Hiromichi Yumoto : MPCポリマーコーティングにおけるTi表面への歯周病原菌付着抑制効果の検討, 徳島大学研究クラスター Joint Meeting on Microbiology 2020, Nov. 2020.
6.	Yuta Kita, Pahlevi Reza Muhammad, Rina Murata, Keiji Murakami, Yuka Hiroshima and Hideki Fujii : バイオフィルム形成緑膿菌におけるPA2384遺伝子の役割について, 徳島大学研究クラスター Joint Meeting on Microbiology 2020, Nov. 2020.
7.	Rina Murata, Keiji Murakami, Yuka Hiroshima, Koichiro Tsuchiya, Keiko Kataoka and Hideki Fujii : 緑膿菌における抗菌薬添加によるスーパーオキシドの発生について, 徳島大学研究クラスター Joint Meeting on Microbiology 2020, Nov. 2020.
8.	喜田悠太, Pahlevi Reza Muhammad, Keiji Murakami, Yuka Hiroshima and Hideki Fujii : 緑膿菌PA2384遺伝子の抗菌薬抵抗性への関与, 四国歯学会第55回例会, Sep. 2019.
9.	鹿庭美奈子, 喜田悠太, Keiji Murakami, Yuka Hiroshima, Takashi Amoh and Hideki Fujii : BNCのインフルエンザ感受性細胞への接着に関与する温度条件, 四国歯学会第54回例会, Mar. 2019.
10.	Keiji Murakami, 村田梨菜, Takashi Amoh, Keiko Kataoka and Hideki Fujii : 緑膿菌臨床分離株における抗菌薬抵抗性と抗酸化能との関連について, 第53回緑膿菌感染症研究会プログラム, Mar. 2019.
11.	Natsumi Fujiwara, Miki Tsurukuma, Kaya Yoshida, Keiji Murakami, Kazumi Ozaki, Hideki Fujii and Hiromichi Yumoto : MPCポリマーコーティングによる義歯用レジンのカンジダ付着抑制効果, 2018 Bioscience retreat in Awaji, Nov. 2018.
12.	Takashi Amoh, Keiji Murakami, Atsushi Tabata, Hideaki Nagamune, Katsuhiko Hirota, Yoichiro Miyake and Hideki Fujii : 幼児口腔内から検出された多剤耐性レンサ球菌について, 第71回日本細菌学会中国，四国支部総会, Oct. 2018.
13.	Mizuki Abe, Narumi Senoh, Keiji Murakami, Takashi Amoh, Hideki Fujii, 佐藤雅美, 笹田倫子, 菅崎幹樹, 森本悠里, 平尾早紀, Akiko Sakurai and Keiko Kataoka : オートインデューサーアナログ(AIA)の緑膿菌に及ぼす影響, 第41回徳島県医学検査学会, Dec. 2017.

Report:

1.	Yoshihiko Ueno, Yosuke Seki, Takuya YABE, Shigenobu Yonemura, Hiroshi Sakaue, Hitoshi Ikushima, Hideki Fujii, Yasuhiko Shirayama, Ken-ichi Yamada, Kazuhiko Kinoshita, Eiji Sakuradani, Ray S. Furuya and Maiko Kamioka : 令和2年度徳島大学高等教育研究センターアドミッション部門報告書, 令和2年度徳島大学高等教育研究センターアドミッション部門報告書, Mar. 2021.
2.	Yoshihiko Ueno, Yosuke Seki, keiji Ido, Yasushi Takagi, Hiroshi Sakaue, Hitoshi Ikushima, Hideki Fujii, Yasuhiko Shirayama, Hideji TANAKA, Masatake Kawada, Hideaki Nagamune, Ray S. Furuya and Maiko Kamioka : 令和元年度徳島大学高等教育研究センターアドミッション部門報告書, 令和元年度徳島大学高等教育研究センターアドミッション部門報告書, Mar. 2020.

Patent:

1.	Hideki Fujii and Keiji Murakami : 殺菌剤及び殺菌方法, (Nov. 2018), .

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

緑膿菌における病原性、抗菌薬抵抗性のトレードオフ機構の解明 (Project/Area Number: 22K08613 )
バイオナノカプセルを用いた高齢者オーラルケアの基礎研究 (Project/Area Number: 20K09941 )
２成分制御系を中心としたバイオフィルム形成菌における抗菌薬抵抗性メカニズムの解明 (Project/Area Number: 18K09535 )
Elucidation of pathomechanisms and Development of new treatment strategies for aseptic pustuloses (Project/Area Number: 15H04886 )
Investigation of immune mechanism of PGD2/CRTH2 in severe infectious diseases (Project/Area Number: 24591488 )
PI3-K plays a critical role in the class switch recombination of immunoglobulin (Project/Area Number: 22590437 )
SARS-coronavirusワクチン開発に関する基礎研究 (Project/Area Number: 16017314 )
抗原提示細胞としてのT細胞と、T細胞活性化、T細胞恒常性維持との関わり (Project/Area Number: 15790260 )
Molecular mechanism for memory B cell dynamics and survival (Project/Area Number: 15390164 )
RNA結合タンパク質(snRNP)複合体を形成するSMNの生物学的機能の解明 (Project/Area Number: 15030243 )
持続性に優れたワクチン開発のための記憶B細胞長期生存に関わる因子の同定 (Project/Area Number: 15019124 )
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