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Tokushima University > Graduate School of Biomedical Sciences > 医学域 > Medical Science > Pathological Sciences > Department of Microbiology >
Tokushima University > Faculty of Medicine > School of Medicine > Course of Microbiology and Immunology > Microbiology >
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Research Activity

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.Naoya Doi, Takaaki Koma, Akio Adachi and Masako Nomaguchi :
Role for Gag-CA Interdomain Linker in Primate Lentiviral Replication.,
Frontiers in Microbiology, Vol.10, 2019.
(DOI: 10.3389/fmicb.2019.01831,   PubMed: 31440231)
2.Takaaki Koma, Osamu Kotani, Kei Miyakawa, Akihide Ryo, Masaru Yokoyama, Naoya Doi, Akio Adachi, Hironori Sato and Masako Nomaguchi :
Allosteric regulation of HIV-1 capsid structure for Gag assembly, virion production, and viral infectivity by a disordered interdomain linker.,
Journal of Virology, 2019.
(DOI: 10.1128/JVI.00381-19,   PubMed: 31189701)
3.Naoya Doi, Masaru Yokoyama, Takaaki Koma, Osamu Kotani, Hironori Sato, Akio Adachi and Masako Nomaguchi :
Concomitant Enhancement of HIV-1 Replication Potential and Neutralization-Resistance in Concert With Three Adaptive Mutations in Env V1/C2/C4 Domains.,
Frontiers in Microbiology, Vol.10, 2019.
(DOI: 10.3389/fmicb.2019.00002,   PubMed: 30705669)
4.Naoya Doi, Tomoyuki Miura, Hiromi Mori, Hiromi Sakawaki, Takaaki Koma, Akio Adachi and Masako Nomaguchi :
CXCR4- and CCR5-Tropic HIV-1 Clones Are Both Tractable to Grow in Rhesus Macaques.,
Frontiers in Microbiology, Vol.9, 2018.
(DOI: 10.3389/fmicb.2018.02510,   PubMed: 30405570)
5.Shoko Nakanishi, Sakimi Watanabe, Naoya Doi, Takaaki Koma, Akio Adachi and Masako Nomaguchi :
Virological characterization of HIV-1 CA-NTD mutants constructed in a virus-lineage reflected manner.,
The Journal of Medical Investigation : JMI, Vol.65, No.1.2, 110-115, 2018.
(Tokushima University Institutional Repository: 111440,   DOI: 10.2152/jmi.65.110,   PubMed: 29593179)
6.Masako Nomaguchi, Naoya Doi, Tomoya Yoshida, Takaaki Koma, Shun Adachi, Hirotaka Ode, Yasumasa Iwatani, Masaru Yokoyama, Hironori Sato and Akio Adachi :
mRNA Is Modulated by Natural Nucleotide Variations and SLSA1 RNA Structure in SA1D2prox Genomic Region.,
Frontiers in Microbiology, Vol.8, No.2542, 2017.
(DOI: 10.3389/fmicb.2017.02542,   PubMed: 29326677,   Elsevier: Scopus)
7.Masako Nomaguchi, Naoya Doi, Takaaki Koma and Akio Adachi :
Complete Genome Sequences of Human Immunodeficiency Type 1 Viruses Genetically Engineered To Be Tropic for Rhesus Macaques.,
Genome Announcements, Vol.5, No.39, 2017.
(DOI: 10.1128/genomeA.01063-17,   PubMed: 28963223)
8.Naoya Doi, Yosuke Sakai, Akio Adachi and Masako Nomaguchi :
Generation and characterization of new CCR5-tropic HIV-1rmt clones,
The Journal of Medical Investigation : JMI, Vol.64, No.3,4, 272-279, 2017.
(DOI: 10.2152/jmi.64.272,   PubMed: 28954995)

Review, Commentary:

1.Masako Nomaguchi, Naoya Doi, Takaaki Koma and Akio Adachi :
HIV-1 mutates to adapt in fluxing environments.,
Microbes and Infection, Oct. 2018.
(DOI: 10.1016/j.micinf.2017.08.003,   PubMed: 28859896)

Proceeding of Domestic Conference:

1.Masako Nomaguchi, Naoya Doi, Takaaki Koma, 吉田 和子 and Akio Adachi :
SA1D2proxに関するHIV-1 Vif低発現変異体NL-gatは,Vif発現量適応変異あるいはenv変異の獲得により増殖能を向上させる,
第66回日本ウイルス学会学術集会, Oct. 2018.
2.Akio Adachi, Naoya Doi, Takaaki Koma, Hayato Ohkubo, 吉田 和子 and Masako Nomaguchi :
SA1D2prox領域に関するHIV-1 Vif超低発現変異体 NL-tacのAPOBEC3G高発現下における適応過程の解析,
第66回日本ウイルス学会学術集会, Oct. 2018.
3.Takaaki Koma, 小谷 治, Naoya Doi, 宮川 敬, 梁 明秀, 横山 勝, 佐藤 裕徳, Akio Adachi and Masako Nomaguchi :
HIV-1複製後期過程におけるGag-CAリンカードメインの役割,
第66回日本ウイルス学会学術集会, Oct. 2018.
4.Naoya Doi, Takaaki Koma, Nina Nakanishi, Akio Adachi and Masako Nomaguchi :
馴化型R5-tropic HIV-1rmtで同定されたEnvによる増殖促進の解析,
第66回日本ウイルス学会学術集会, Oct. 2018.
5.Shoko Nakanishi, Sakimi Watanabe, Naoya Doi, Takaaki Koma, Akio Adachi and Masako Nomaguchi :
Single-amino acid mutations in V1 and C4 domains of HIV-1 Env cooperatively enhance viral replication ability by increasing CD4 affinity,
第65回日本ウイルス学会学術集会, Oct. 2017.
6.Sakimi Watanabe, Shoko Nakanishi, Takaaki Koma, Naoya Doi, Akio Adachi and Masako Nomaguchi :
Low vif type of HIV-1 SA1D2prox variants can adaptively mutate to enhance the Vif expression under the strong restrictive condition,
第65回日本ウイルス学会学術集会, Oct. 2017.
7.Naoya Doi, Takaaki Koma, Shoko Nakanishi, Sakimi Watanabe, Masako Nomaguchi and Akio Adachi :
Generation of R5-tropic HIV-1rmt clones with an enhanced replication ability by adaptive Env domain swapping,
第65回日本ウイルス学会学術集会, Oct. 2017.
8.Akio Adachi, Naoya Doi, Takaaki Koma, Shoko Nakanishi, Sakimi Watanabe and Masako Nomaguchi :
Linkage analysis of HIV-1 vif production level and SLSA1 structure/energy stability,
第65回日本ウイルス学会学術集会, Oct. 2017.
9.Takaaki Koma, Naoya Doi, 宮川 敬, 梁 明秀, Akio Adachi and Masako Nomaguchi :
Role for amino acid residues S149 and I150 of the Gag-CA linker domain in the late HIV-1 replication phase,
第65回日本ウイルス学会学術集会, Oct. 2017.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)