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Tokushima University > Research Clusters > Research Clusters (Prioritized) > 1802003 がんの統合的診断・治療を目指した分子から組織のマルチスケール・バイブレーショナル光学顕微鏡の創成 >
Tokushima University > Faculty of Engineering > Department of Mechanical Engineering > Mechanical Systems >
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Research Activity

Field of Study

Engineering, Biomedical Engineering, Biomechanics

Subject of Study

Nonequilibrium Biomolecular Dynamics, Pulmonary acinar biomechanics, Molecular Basis of Drug Delivery Systems

Book / Paper

Book:

1. Kenichiro Koshiyama :
生命科学で使える初めての数理モデルとシミュレーション,
YODOSHA CO., LTD., Mar. 2017.
2. Kenichiro Koshiyama :
マイクロ/ナノカプセルの調製,徐放性制御と応用事例,
Technical Information Institute Co., Ltd., Oct. 2014.

Academic Paper (Judged Full Paper):

1. Kenichiro Koshiyama, Masaki Taneo, Taiki Shigematsu and Shigeo Wada :
Bicelle-to-Vesicle Transition of a Binary Phospholipid Mixture Guided by Controlled Local Lipid Compositions: A Molecular Dynamics Simulation Study.,
The Journal of Physical Chemistry B, Vol.123, No.14, 3118-3123, 2019.
(Tokushima University Institutional Repository: 113243,   DOI: 10.1021/acs.jpcb.8b10682,   PubMed: 30888822,   Elsevier: Scopus)
2. Taiki Shigematsu, Kenichiro Koshiyama and Shigeo Wada :
Stretch-Induced Interdigitation of a Phospholipid/Cholesterol Bilayer.,
The Journal of Physical Chemistry B, Vol.122, No.9, 2556-2563, 2018.
(DOI: 10.1021/acs.jpcb.7b10633,   PubMed: 29419298,   Elsevier: Scopus)
3. Kenichiro Koshiyama, Keisuke Nishimoto, Satoshi Ii, Toshihiro Sera and Shigeo Wada :
Heterogeneous structure and surface tension effects on mechanical response in pulmonary acinus: A finite element analysis.,
Clinical Biomechanics, 2018.
(DOI: 10.1016/j.clinbiomech.2018.01.001,   PubMed: 29370949)
4. Philipp Hofemeier, Kenichiro Koshiyama, Shigeo Wada and Josué Sznitman :
One (sub-)acinus for all: Fate of inhaled aerosols in heterogeneous pulmonary acinar structures.,
European Journal of Pharmaceutical Sciences, Vol.113, 53-63, 2017.
(DOI: 10.1016/j.ejps.2017.09.033,   PubMed: 28954217,   Elsevier: Scopus)
5. Luosha Xiao, Toshihiro Sera, Kenichiro Koshiyama and Shigeo Wada :
Morphological Characterization of Acinar Cluster in Mouse Lung Using a Multiscale-based Segmentation Algorithm on Synchrotron Micro-CT Images.,
The Anatomical Record, Vol.299, No.10, 1424-1434, 2016.
(DOI: 10.1002/ar.23452,   PubMed: 27488590)
6. Kenichiro Koshiyama and Shigeo Wada :
Collapse of a lipid-coated nanobubble and subsequent liposome formation.,
Scientific Reports, Vol.6, 2016.
(DOI: 10.1038/srep28164,   PubMed: 27306704)
7. Taiki Shigematsu, Kenichiro Koshiyama and Shigeo Wada :
Effects of Stretching Speed on Mechanical Rupture of Phospholipid/Cholesterol Bilayers: Molecular Dynamics Simulation.,
Scientific Reports, Vol.5, 2015.
(DOI: 10.1038/srep15369,   PubMed: 26471872)
8. Kenichiro Koshiyama and Shigeo Wada :
Mathematical model of a heterogeneous pulmonary acinus structure.,
Computers in Biology and Medicine, Vol.62, 25-32, 2015.
(DOI: 10.1016/j.compbiomed.2015.03.032,   PubMed: 25912985)
9. Taiki SHIGEMATSU, Kenichiro Koshiyama and Shigeo WADA :
Line tension of the pore edge in phospholipid/cholesterol bilayer from stretch molecular dynamics simulation,
Journal of Biomechanical Science and Engineering, Vol.11, No.1, 15-00422-15-00422, 2015.
(DOI: 10.1299/jbse.15-00422,   CiNii: 130005157932)
10. Yoshihiro Ujihara, Masanori Nakamura, Masatsugu Soga, Kenichiro Koshiyama, Hiroshi Miyazaki and Shigeo Wada :
Computational studies on strain transmission from a collagen gel construct to a cell and its internal cytoskeletal filaments.,
Computers in Biology and Medicine, Vol.56, 20-29, 2014.
(DOI: 10.1016/j.compbiomed.2014.10.015,   PubMed: 25464345)
11. Taiki Shigematsu, Kenichiro Koshiyama and Shigeo Wada :
Molecular dynamics simulations of pore formation in stretched phospholipid/cholesterol bilayers.,
Chemistry and Physics of Lipids, Vol.183, 43-49, 2014.
(DOI: 10.1016/j.chemphyslip.2014.05.005,   PubMed: 24863643)
12. Luosha Xiao, Toshihiro Sera, Kenichiro Koshiyama and Shigeo Wada :
A semiautomatic segmentation algorithm for extracting the complete structure of acini from synchrotron micro-CT images.,
Computational and Mathematical Methods in Medicine, Vol.2013, 2013.
(DOI: 10.1155/2013/575086,   PubMed: 23533543)
13. Masanori NAKAMURA, Yoshihiro UJIHARA, Masatsugu SOGA, Kenichiro Koshiyama, Hiroshi MIYAZAKI and Shigeo WADA :
Effects of Cytoskeletal Orientations on Deformation of a Cell Residing in a Collagen Gel Construct,
Journal of Biomechanical Science and Engineering, Vol.7, No.1, 2-14, 2012.
(DOI: 10.1299/jbse.7.2,   CiNii: 130002066875)
14. Kenichiro Koshiyama and Shigeo Wada :
Molecular dynamics simulations of pore formation dynamics during the rupture process of a phospholipid bilayer caused by high-speed equibiaxial stretching.,
Journal of Biomechanics, Vol.44, No.11, 2053-2058, 2011.
(DOI: 10.1016/j.jbiomech.2011.05.014,   PubMed: 21658696)
15. Masato YASUI, Kenichiro Koshiyama and Shigeo WADA :
Modeling of Lung Microstructure Using Phase-Field Method,
Transactions of the Japanese Society for Medical and Biological Engineering, Vol.49, No.1, 250-254, 2011.
(DOI: 10.11239/jsmbe.49.250,   CiNii: 130004947431)
16. Kenichiro Koshiyama, Takeru Yano and Tetsuya Kodama :
Self-organization of a stable pore structure in a phospholipid bilayer.,
Physical Review Letters, Vol.105, No.1, 2010.
(DOI: 10.1103/PhysRevLett.105.018105,   PubMed: 20867485)
17. Tetsuya KODAMA, Yukio TOMITA, Yukiko WATANABE, Kenichiro Koshiyama, Takeru YANO and Shigeo FUJIKAWA :
Cavitation Bubbles Mediated Molecular Delivery During Sonoporation,
Journal of Biomechanical Science and Engineering, Vol.4, No.1, 124-140, 2009.
(DOI: 10.1299/jbse.4.124,   CiNii: 130000107450)
18. Kenichiro Koshiyama, Tetsuya Kodama, Takeru Yano and Shigeo Fujikawa :
Molecular dynamics simulation of structural changes of lipid bilayers induced by shock waves: Effects of incident angles.,
Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1778, No.6, 1423-1428, 2008.
(DOI: 10.1016/j.bbamem.2008.03.010,   PubMed: 18405658)
19. Kenichiro Koshiyama, Tetsuya Kodama, Takeru Yano and Shigeo Fujikawa :
Structural change in lipid bilayers and water penetration induced by shock waves: molecular dynamics simulations.,
Biophysical Journal, Vol.91, No.6, 2198-2205, 2006.
(DOI: 10.1529/biophysj.105.077677,   PubMed: 16798798)
20. Tetsuya Kodama, Yukio Tomita, Kenichiro Koshiyama and K Martin J Blomley :
Transfection effect of microbubbles on cells in superposed ultrasound waves and behavior of cavitation bubble.,
Ultrasound in Medicine & Biology, Vol.32, No.6, 905-914, 2006.
(DOI: 10.1016/j.ultrasmedbio.2006.03.004,   PubMed: 16785012)
21. Tetsuya Kodama, Atsuko Aoi, Georges Vassaux, Shiro Mori, Hidehiro Morikawa, Kenichiro Koshiyama, Takeru Yano, Shigeo Fujikawa and Yukio Tomita :
A non-invasive tissue-specific molecular delivery method of cancer gene therapy.,
Minimally Invasive Therapy & Allied Technologies, Vol.15, No.4, 226-229, 2006.
(DOI: 10.1080/13645700600836059,   PubMed: 16966136)

Review, Commentary:

1. 和田 成生, Kenichiro Koshiyama, 肖 蘿莎 and 世良 俊博 :
肺のミクロ—マクロ力学場の統合に向けた肺細葉の形態解析と数理モデリング,
Respiration & Circulation, Vol.62, No.12, 1179-1187, Dec. 2014.
(DOI: 10.11477/mf.1404200054)
2. Kenichiro Koshiyama :
細胞膜分子動力学シミュレーションと医工学技術開発の融合,
計算数理工学レビュー, Vol.2013, No.1, 27-33, Mar. 2013.

Proceeding of International Conference:

1. Kenichiro Koshiyama, Keisuke Nishimoto, Satoshi Ii, Toshihiro Sera and Shigeo Wada :
Anisotropic deformation of pulmonary acinar tissues for inflation with surface tension effects,
8th World Congress of Biomechanics, Dublin, Ireland, Jul. 2018.

Proceeding of Domestic Conference:

1. Kenichiro Koshiyama, 伊井 仁志, 世良 俊博 and 和田 成生 :
吸気時の肺細葉内局所力学場に関する数値的検討:表面張力効果,
第27回バイオフィジオロジー研究会抄録集, 10-11, Mar. 2019.
2. 種子尾 将希, Kenichiro Koshiyama, 重松 大輝, Kenichiro Koshiyama and 和田 成生 :
-,
日本機械学会第31回バイオエンジニアリング講演会講演論文集, 1G33, Dec. 2018.
3. 竹田 圭佑, 伊井 仁志, 吉永 司, Kenichiro Koshiyama and 和田 成生 :
-,
日本機械学会第31回バイオエンジニアリング講演会講演論文集, 1G13, Dec. 2018.
4. 重松 大輝, Kenichiro Koshiyama and 和田 成生 :
-,
日本機械学会第31回バイオエンジニアリング講演会講演論文集, 1A24, Dec. 2018.
5. Kenichiro Koshiyama :
All atom molecular dynamics simulations of ceramide bilayers under compressive loading,
日本機械学会2018年度年次大会講演論文集, No.J0250001, Sep. 2018.
6. 伊井 仁志, 竹田 圭佑, Kenichiro Koshiyama and 和田 成生 :
Understanding the lung crackle sounds by fluid-structure-acoustic interaction analysis,
計算工学講演会論文集 Proceedings of the Conference on Computational Engineering and Science, Vol.23, 3p, Jun. 2018.
(CiNii: 40021576460)
7. Kenichiro Koshiyama and Shigeo WADA :
Molecular Dynamics Simulations of Lipid Coated Nanobubble under Cyclic Pressure Changes,
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Vol.2018, No.0, 1G04, 2018.
(DOI: 10.1299/jsmebio.2018.30.1G04,   CiNii: 130007410814)
8. Masaki TANEO, Kenichiro Koshiyama, Taiki SHIGEMATSU and Shigeo WADA :
The Formation of Nanoliposome Composed of Binary Mixture Lipids::Molecular Dynamics Simulation,
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Vol.2018, No.0, 1G07, 2018.
(DOI: 10.1299/jsmebio.2018.30.1G07,   CiNii: 130007410828)
9. Taiki SHIGEMATSU, Kenichiro Koshiyama and Shigeo WADA :
Molecular Partitioning and Line Tension of Pore Edge in Mixed-Lipid Bilayers::Molecular Dynamics Simulation,
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Vol.2018, No.0, 1G08, 2018.
(DOI: 10.1299/jsmebio.2018.30.1G08,   CiNii: 130007410829)
10. Keisuke TAKEDA, Tsukasa YOSHINAGA, Kenichiro Koshiyama, Satoshi II and Shigeo WADA :
Acoustic analysis of lung sound distribution using airway branching model in pulmonary lobes based on real shape,
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Vol.2018, No.0, 2F05, 2018.
(DOI: 10.1299/jsmebio.2018.30.2F05,   CiNii: 130007411026)
11. Ryogo ENOSAKI, Satoshi II, Naoki TAKEISHI, Kenichiro Koshiyama, Daiki SHIGEMATSU and Shigeo WADA :
Computer simulation of fibrin clot formation using protofibril aggregation model::evaluation of the morphological characteristics,
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Vol.2018, No.0, 2E07, 2018.
(DOI: 10.1299/jsmebio.2018.30.2E07,   CiNii: 130007411049)
12. Kenichiro Koshiyama :
Molecular dynamics simulations of ceramide bilayer failure,
The Proceedings of Mechanical Engineering Congress, Japan, Vol.2017, No.0, J0220105, 2017.
(DOI: 10.1299/jsmemecj.2017.J0220105,   CiNii: 130006550122)
13. Ryogo ENOSAKI, Satoshi II, Naoki TAKEISHI, Kenichiro Koshiyama, Taiki SHIGEMATSU and Shigeo WADA :
Mesoscopic numerical approach for fibrin clot formation using discrete element model,
The Proceedings of The Computational Mechanics Conference, Vol.2017, No.0, 67, 2017.
(DOI: 10.1299/jsmecmd.2017.30.067,   CiNii: 130006551049)
14. Keisuke TAKEDA, Tsukasa YOSHINAGA, Kenichiro Koshiyama, Satoshi II and Shigeo WADA :
Sound analysis using airway branching model based on real shape,
The Proceedings of the JSME Conference on Frontiers in Bioengineering, Vol.2017, No.0, 2C12, 2017.
(DOI: 10.1299/jsmebiofro.2017.28.2C12,   CiNii: 130006726556)
15. Masaki TANEO, Kenichiro Koshiyama, Taiki SHIGEMATSU and Shigeo WADA :
Effect of Lipid Composition on Nanoliposome Formation: Molecular Dynamics Simulation,
The Proceedings of the JSME Conference on Frontiers in Bioengineering, Vol.2017, No.0, 1B22, 2017.
(DOI: 10.1299/jsmebiofro.2017.28.1B22,   CiNii: 130006726384)
16. Taiki SHIGEMATSU, Kenichiro Koshiyama and Shigeo WADA :
Effects of Phase Transition on Pore Formation in Stretched Phospholipid/Cholesterol Bilayer:Molecular Dynamics Simulation,
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Vol.2017, No.0, 1F34, 2017.
(DOI: 10.1299/jsmebio.2017.29.1F34,   CiNii: 130007126813)
17. Naoya ANDO, Kenichiro Koshiyama, Manabu KINOSHITA and Shigeo WADA :
1H15 Real time observations of the molecular delivery in in vitro sonoporation : effects of ultrasound conditions on the delivery timing,
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Vol.2016, No.0, _1H15-1_-_1H15-5_, 2016.
(DOI: 10.1299/jsmebio.2016.28._1H15-1_,   CiNii: 110010052132)
18. Ryotaro KURUMATANI, Kenichiro Koshiyama and Shigeo WADA :
Molecular Dynamics Simulations of PEGylated-liposome Rupture Induced by High-speed Mechanical Loading,
The Proceedings of Mechanical Engineering Congress, Japan, Vol.2016, No.0, J0210101, 2016.
(DOI: 10.1299/jsmemecj.2016.J0210101,   CiNii: 130007064396)
19. Keisuke NISHIMOTO, Kenichiro Koshiyama, Satoshi II and Shigeo WADA :
Deformation Analysis of Heterogeneous Pulmonary Acinus Structure with Considering Effects of Surface Tension,
The Proceedings of the JSME Conference on Frontiers in Bioengineering, Vol.2016, No.0, C213, 2016.
(DOI: 10.1299/jsmebiofro.2016.27.C213,   CiNii: 130007119316)
20. Taiki SHIGEMATSU, Kenichiro Koshiyama and Shigeo WADA :
1C42 Molecular dynamics simulation of water permeability through stretched phospholipid/cholesterol bilayer,
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Vol.2015, No.0, 127-128, 2015.
(DOI: 10.1299/jsmebio.2015.27.127,   CiNii: 110009965274)
21. Asuka NISHIKAWA, Kenichiro Koshiyama and Shigeo WADA :
2F33 Modeling of heterogeneous micro vasculature network at the pulmonary acinus level,
The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, Vol.2015, No.0, 535-536, 2015.
(DOI: 10.1299/jsmebio.2015.27.535,   CiNii: 110009965478)
22. Taiki SHIGEMATSU, Kenichiro Koshiyama and Shigeo WADA :
617 Mutual Effects of Cholesterol and Stretching Speed on Rupture of Phospholipid Bilayers under Stretching : Molecular Dynamics Simulation,
The Proceedings of Conference of Kansai Branch, Vol.2015, No.0, 259-260, 2015.
(DOI: 10.1299/jsmekansai.2015.90.259,   CiNii: 110009965689)
23. Yukiho ISHIDA, Satoshi II, Hideo HIRAKATA, Naoko SUGITA, Kenichiro Koshiyama and Shigeo WADA :
P016 A blood-clot formation model considering biochemical reactions and viscoelasticity of thrombus,
The Proceedings of Conference of Kansai Branch, Vol.2015, No.0, 434, 2015.
(DOI: 10.1299/jsmekansai.2015.90.434,   CiNii: 110009966220)
24. Kenichiro Koshiyama and Shigeo WADA :
0313 Molecular Dynamics Simulations of Lipid Coated Nanobubble,
The Proceedings of the Fluids engineering conference, Vol.2015, No.0, _0313-1_-_0313-2_, 2015.
(DOI: 10.1299/jsmefed.2015._0313-1_,   CiNii: 110010047097)
25. Ryotaro KURUMATANI, Taiki SHIGEMATSU, Kenichiro Koshiyama and Shigeo WADA :
J0270201 Molecular Dynamics Study about Water Permeability Change of Lipid Membranes under Stretching : toward Development of Liposomes for Drug Delivery,
The Proceedings of Mechanical Engineering Congress, Japan, Vol.2015, No.0, _J0270201--_J0270201-, 2015.
(DOI: 10.1299/jsmemecj.2015._J0270201-,   CiNii: 110010048720)
26. Ryotaro KURUMATANI, Taiki SHIGEMATSU, Kenichiro Koshiyama and Shigeo WADA :
B211 Coarse grained molecular dynamics simulations of nano-liposome rupture induced by mechanical stresses,
The Proceedings of the JSME Conference on Frontiers in Bioengineering, Vol.2015, No.0, 121-122, 2015.
(DOI: 10.1299/jsmebiofro.2015.26.121,   CiNii: 110010051948)

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 肺リモデリングメカニズムの解明に向けた気道末梢部位の力学環境と細胞力学応答解析 (Project/Area Number: 19H04444 )
  • 小児肺細葉バイオメカニクスの創成 (Project/Area Number: 18K19921 )
  • Therapeutic system for metastatic lymph nodes at early stages (Project/Area Number: 17H00865 )
  • What is the reason to form the thrombi with different internal structures and mechanical characteristics? (Project/Area Number: 15K12510 )
  • Next-generation ultrasound contrast agent development platform based on elucidating the physical phenomenon of lipid coated nanobubbles (Project/Area Number: 15K01284 )
  • Multiscale mechanical modeling and analysis of the lung for better understanding of the pathological remodeling mechanism (Project/Area Number: 24240073 )
  • Molecular mechanisms about ultrasound neuromodulation (Project/Area Number: 23686031 )
  • Three dimensional measurements of collagen structure in a vascular tissue subject to abnormal mechanical remodeling (Project/Area Number: 23650261 )
  • Towards the establishment of hemolysis simulator by a multi-scale analysis and experimental observations of damages on a red blood cell membrane and (Project/Area Number: 22300155 )
  • Molecular Mechanisms about Changes of Cell Membranes Functions : Induced by Shear Forces (Project/Area Number: 20760114 )
  • Computational studies on the development of intracranial aneurysms considering arterial wall remodeling induced by hemodynamics factors (Project/Area Number: 17300138 )
  • Search by Researcher Number (80467513)