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Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 薬学域 ⟩ Pharmaceutical Science ⟩ Pharmaceutical Sciences ⟩ Department of Theoretical Chemistry for Drug Discovery ⟩
Tokushima University ⟩ Research Clusters ⟩ Research Clusters ⟩ 2201004 医薬・農薬・診断薬に展開可能な鍵物質創製 ⟩
Tokushima University ⟩ Research Clusters ⟩ Research Clusters ⟩ 2202004 次世代DDS拠点形成:従来DDSの常識を超えた薬物送達技術の開発と難治性疾患治療への展開 ⟩
Tokushima University ⟩ Graduate School of Pharmaceutical Sciences ⟩ Pharmaceutical Sciences ⟩
Tokushima University ⟩ Faculty of Pharmaceutical Sciences ⟩ School of Pharmaceutical Technosciences ⟩ 創薬学講座 ⟩ Theoretical Chemistry for Drug Discavery ⟩ 		(Files for researchmap) [PDF manual] [Auto-propagate to researchmap]

Research

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Field of Study

○ Life sciences [Pharmaceuticals - analytical and physicochemistry]
○ Life sciences [Pharmaceuticals - chemistry and drug development]
○ Life sciences [Clinical pharmacy]

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1. Makoto Amifuji, Mai Inagaki, Masahito Yoshida, Takayuki Doi and Masanori Tachikawa :
Characteristics of membrane transport, metabolism, and target protein binding of cyclic depsipeptide destruxin E in HeLa cells,
Drug Metabolism and Pharmacokinetics, Vol.58, 101028, 2024.
(DOI: 10.1016/j.dmpk.2024.101028,   PubMed: 39265438,   Elsevier: Scopus)
2. Kazuki Sone, Yuka Sakamaki, Satomi Hirose, Mai Inagaki, Masanori Tachikawa, Daisuke Yoshino and Kenichi Funamoto :
Hypoxia suppresses glucose-induced increases in collective cell migration in vascular endothelial cell monolayers,
Scientific Reports, Vol.14, No.1, 5164, 2024.
(DOI: 10.1038/s41598-024-55706-1,   PubMed: 38431674,   Elsevier: Scopus)
3. Mai Inagaki and Masanori Tachikawa :
Transport characteristics of placenta-derived extracellular vesicles and its relevance to placenta-to-maternal tissues communication.,
Chemical & Pharmaceutical Bulletin, Vol.70, No.5, 324-329, 2022.
(DOI: 10.1248/cpb.c22-00072,   PubMed: 35491187)
4. Keisuke Kitakaze, Miho Oyadomari, Jun Zhang, Yoshimasa Hamada, Yasuhiro Takenouchi, Kazuhito Tsuboi, Mai Inagaki, Masanori Tachikawa, Yoshio Fujitani, Yasuo Okamoto and Seiichi Oyadomari :
ATF4-mediated transcriptional regulation protects against β-cell loss during endoplasmic reticulum stress in a mouse model.,
Molecular Metabolism, Vol.54, 2021.
(DOI: 10.1016/j.molmet.2021.101338,   PubMed: 34547510,   Elsevier: Scopus)
5. Ryuta Jomura, Yu Tanno, Shin-Ichi Akanuma, Yoshiyuki Kubo, Masanori Tachikawa and Ken-Ichi Hosoya :
Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes.,
American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.321, No.2, G113-G122, 2021.
(DOI: 10.1152/ajpgi.00143.2021,   PubMed: 34075817)
6. S Sasaki, Y Zheng, T Mokudai, H Kanetaka, Masanori Tachikawa, M Kanzaki and T Kaneko :
Continuous release of O2/ONOO in plasma-exposed HEPES-buffered saline promotes TRP channel-mediated uptake of a large cation.,
Plasma Processes and Polymers, e1900257--, 2020.
(Tokushima University Institutional Repository: 116825,   DOI: 10.1002/ppap.201900257,   Elsevier: Scopus)

Review, Commentary:

1. Mai Inagaki and Masanori Tachikawa :
胎盤 - 母体臓器連関を担う細胞外小胞の輸送機構,
月刊『細胞』, Vol.56, No.3, 13-16, Mar. 2024.
2. Masanori Tachikawa and Mai Inagaki :
脳の発達を支える血液脳関門物流システムの可塑的変化,
Clinical Neuroscience, Vol.40, No.12, 1540-1543, Dec. 2022.

Proceeding of International Conference:

1. Masanori Tachikawa, Moemi Hidaka, Yuka Sakamaki, Kenichi Funamoto and Mai Inagaki :
Usefulness of the human blood-brain barrier on a chip for brain-targeting drug development,
Twentieth International Conference on Flow Dynamics, Nov. 2023.
2. Eisuke Nakano, Mai Inagaki and Masanori Tachikawa :
Reuptake mechanisms of human placental trophoblast cells-derived extracellular vesicles in the placental trophoblast cells,
2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of Japanese Society for the Study of Xenobiotics, Sep. 2023.
3. Toshiki Shimizu, Mai Inagaki, Makoto Amifuji, Shota Sasaki, Toshiro Kaneko and Masanori Tachikawa :
Differential enhancement effects of non-equilibrium atmospheric pressure plasma irradiation on membrane transport in human-derived cells,
2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of Japanese Society for the Study of Xenobiotics, Sep. 2023.
4. Sakura Mama, Mai Inagaki, Harunori Yoshikawa, Ken Imai and Masanori Tachikawa :
Determination of transporter mRNA levels in the isolated polysomes of human blood-brain barrier endothelial cells,
2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of Japanese Society for the Study of Xenobiotics, Sep. 2023.
5. Hiroaki Yata, Tsubasa Inokuma, Mai Inagaki, Makoto Amifuji and Masanori Tachikawa :
Glucose transporter-mediated transport of newly synthesized creatine analog in human blood brain barrier endothelial cells,
2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of Japanese Society for the Study of Xenobiotics, Sep. 2023.
6. Kai Hirasawa, Mai Inagaki, Miku Inai, Makoto Amifuji, Hidetaka Kosako and Masanori Tachikawa :
Proteomics-based comparison of transporter expression profiles in BeWo and JEG-3 cells,
International Federation of Placenta Association 2023, Sep. 2023.
7. Mai Inagaki, Eisuke Nakano and Masanori Tachikawa :
Reuptake system of extracellular vesicles in human trophoblast cell line,
International Federation of Placenta Association 2023, Sep. 2023.
8. Mai Inagaki, Masahito Yoshida, Tsukasa Sugiyama, Ayaka Taii, Yu Tsuyusaki, Tomohide Goto, Takahito Wada, Takayuki Doi, Tetsuya Terasaki and Masanori Tachikawa :
y+L-type amino acid transporter y+LAT2 functions as a transport system for creatine prodrug in human brain microvessel endothelial cells,
The Cerebral Vascular Biology, CVB 2023 meeting, Jun. 2023.
9. Masanori Tachikawa, Mai Inagaki, Kenichi Funamoto, Hinori Sano, Eisuke Nakano, Miku Inai, Momoko Sato and Yuka Sakamaki :
Characteristics of placenta-derived extracellular vesicles (pEVs) at the human blood-brain barrier,
The Cerebral Vascular Biology, CVB 2023 meeting, Jun. 2023.
10. Masanori Tachikawa, Mai Inagaki, Hinori Sano, Momoko Sato, Hidetaka Kosako and Kenichi Funamoto :
Placenta-derived Extracellular Vesicles: their unique characteristics of the Blood-Brain Barrier (BBB) transport,
25th Symposium Signal Transduction at the Blood-Brain Barriers, Jun. 2023.
11. Masanori Tachikawa :
Decoding, Building, and Manipulating of the Human Blood-Brain Barrier: Perspectives on Brain-targeting Drug Delivery Systems,
43rd Pharmacological and Therapeutic Society of Thailand Meeting, Bangkok, May 2023.
12. Masanori Tachikawa and Mai Inagaki :
Placenta-derived Extracellular Vesicles: their uniqueness and characteristics of the human Blood-Brain Barrier transport.,
15th International Symposium on Nanomedicine (ISMN2022), Dec. 2022.
13. Yuka Sakamaki, Mai Inagaki, Momoko Sato, Kenichi Funamoto and Masanori Tachikawa :
Visualization of extracellular vesicles transport across brain microvasculature in a human 3D blood-brain barrier chip,
Nineteenth International Conference on Flow Dynamics, Nov. 2022.
14. Momoko Sato, Mai Inagaki, Yuka Sakamaki, Kenichi Funamoto and Masanori Tachikawa :
Reconstruction of 3D human brain microvasculature on a chip using brain endothelial cells, astrocytes and pericytes,
Eighteenth International Conference on Flow Dynamics, Oct. 2021.
15. Yuka Sakamaki, Mai Inagaki, Momoko Sato, Kenichi Funamoto and Masanori Tachikawa :
Reconstruction of perfusable human 3D microvasculature on a chip as an evaluation model of cancer cell extravasation and drug transport,
Eighteenth International Conference on Flow Dynamics, Oct. 2021.
16. Momoko Sato, Yuka Sakamaki, Mai Inagaki, Kenichi Funamoto and Masanori Tachikawa :
3D Human Blood-Brain Barrier Chip for Central Nervous System Drug Development,
Seventeenth International Conference on Flow Dynamics, Oct. 2020.
17. Masanori Tachikawa, Hiroki Kuroda, Yasuo Uchida and Tetsuya Terasaki :
The human-specific virus receptor CD46 makes a major contribution to the internalization of brain-metastatic melanoma-derived exosomes by human blood-brain barrier endothelial cells.,
13th International Conference of Cerebral Vascular Biology (CVB2019), Jun. 2019.

Proceeding of Domestic Conference:

1. 矢田 浩晃, 猪熊 翼, Mai Inagaki, 網藤 惇 and Masanori Tachikawa :
血液脳関門グルコーストランスポーターを介して輸送されるクレアチンプロドラッグの開発,
日本薬剤学会第39年会, May 2024.
2. 平沢 介, 茂谷 康, Mai Inagaki, 田良島 典子, 南川 典昭, 小迫 英尊 and Masanori Tachikawa :
ヒト脳微小血管内皮細胞におけるSTING経路活性化に伴う細胞膜タンパク質変動の解明,
日本薬剤学会第39年会, May 2024.
3. 万々 桜, Mai Inagaki, 吉川 治孝 and Masanori Tachikawa :
ヒト脳微小血管内皮細胞ポリソーム画分における輸送体mRNAの発現量解析,
日本薬剤学会第39年会, May 2024.
4. 橋本 彩伽, Mai Inagaki, 田良島 典子, 南川 典昭 and Masanori Tachikawa :
ヒト血液脳関門・くも膜関門におけるcGAS-STING経路が関わる自然免疫応答機構の役割,
日本薬剤学会第39年会, May 2024.
5. 日高 萌実, 佐々木 一成, Mai Inagaki and Masanori Tachikawa :
グローバルプロテオミクスによる妊娠マウスの脳微小血管において発現変動するタンパク質の同定,
日本薬学会第144年会, Mar. 2024.
6. 佐野 陽乃里, 山本 圭, Mai Inagaki, 三木 寿美, 髙塚 雅貴 and Masanori Tachikawa :
ヒト胎盤絨毛細胞から分泌される細胞外小胞の特性とヒト脳微小血管内皮細胞への取り込み機構,
日本薬学会第144年会, Mar. 2024.
7. 稲井 美紅, Mai Inagaki, 田丸 浩 and Masanori Tachikawa :
スイホウガンを用いた抗ヒト脳微小血管内皮細胞抗体の作製,
日本薬学会第144年会, Mar. 2024.
8. 橋本 彩伽, Mai Inagaki, 酒巻 祐花, 万々 桜, 梶 弘和 and Masanori Tachikawa :
ヒト脳関門を模倣するスフェロイド・マイクロ流体モデル,
2023年度生体医歯工学共同研究拠点成果報告会, Mar. 2024.
9. Masanori Tachikawa and Mai Inagaki :
プロテオミクス×マイクロ流体デバイスで挑むヒト血液脳関門を突破する抗体開発,
第45回日本神経組織培養研究会, Dec. 2023.
10. 髙塚 雅貴, Mai Inagaki and Masanori Tachikawa :
フローサイトメトリーと超解像度顕微鏡を用いたヒト脳血管内皮細胞における胎盤由来細胞外小胞の取込み特性と細胞内局在性解析,
第62回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, Oct. 2023.
11. Masanori Tachikawa and Mai Inagaki :
胎盤-脳連関機構に立脚したヒト血液脳関門・細胞外小胞輸送システムの解明,
第44回生体膜と薬物の相互作用シンポジウム, Oct. 2023.
12. 網藤 惇, 今野 源, 吉田 将人, 土井 隆行, Mai Inagaki, 寺崎 哲也 and Masanori Tachikawa :
中分子環状デプシペプチドDestruxin Eの細胞内動態を規定する取り込み，排出及び代謝機構の解明,
第44回生体膜と薬物の相互作用シンポジウム, Oct. 2023.
13. Masanori Tachikawa :
Coordinated roles of glymphatic system and brain barriers,
2023 International Joint Meeting of 23rd ICCP450/38th JSSX, Sep. 2023.
14. 平沢 介, 茂谷 康, Mai Inagaki, 小迫 英尊 and Masanori Tachikawa :
Biotinylation by Antibody Recognition法を用いたヒト脳血管内皮細胞におけるCD147-膜輸送体複合体の分子実体解明,
日本薬剤学会第38年会, May 2023.
15. Makoto Amifuji, Mai Inagaki, 吉田 将人, 土井 隆行 and Masanori Tachikawa :
ヒト胎盤栄養膜細胞(BeWo細胞)におけるクレアチンプロドラッグ輸送機構の解明,
日本薬学会第143年会, Mar. 2023.
16. 繁昌 志帆, 手賀 悠真, 赤沼 伸乙, 久保 義行, Mai Inagaki, Masanori Tachikawa and 細谷 健一 :
ヒト脳毛細血管内皮細胞株hCMEC/D3細胞におけるcreatine輸送の特徴,
日本薬学会第143年会, Mar. 2023.
17. Mai Inagaki, 中野 瑛介 and Masanori Tachikawa :
胎盤分泌細胞外小胞のヒト胎盤栄養膜細胞への内在化機構,
日本薬学会第143年会, Mar. 2023.
18. Terutsugu Tanizawa, Mai Inagaki, Hidetaka Kosako, Hidenori ANDO, Tatsuhiro Ishida and Masanori Tachikawa :
抗ヒト脳微小血管内皮細胞抗体の標的受容体の探索,
日本薬学会第143年会, Mar. 2023.
19. HASHIMOTO Ayaka, Mai Inagaki, Noriko Saito-Tarashima, Shunya Yamauchi, Noriaki Minakawa and Masanori Tachikawa :
環状ジヌクレオチドによるヒト脳微小血管内皮細胞STING経路の活性化,
日本薬学会第143年会, Mar. 2023.
20. Masanori Tachikawa :
研究の神様はチャンスをくれた―小さなクレアチントランスポーター欠損症研究の物語∼クレアチン脳欠乏症を治療可能な小児神経疾患に,
第28回小児神経症例検討会, Feb. 2023.
21. Masanori Tachikawa :
ヒト血液脳関門-Blood-Brain Barrier (BBB)-を知る，創る，操る:物流システムの解明からHuman BBB on-a-Chipへの展開,
化学とマイクロ・ナノシステム学会 第46回研究会, Nov. 2022.
22. Mai Inagaki, 佐藤 桃子, 船本 健一 and Masanori Tachikawa :
マイクロ流体デバイス上に構築した3次元ヒト脳血管網の特性解析,
第37回日本薬物動態学会, Nov. 2022.
23. 今井 健, Mai Inagaki, 佐藤 桃子, 船本 健一 and Masanori Tachikawa :
マイクロ流体デバイスを用いた3次元ヒト脳血管網の再構築,
第61回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, Nov. 2022.
24. 中野 瑛介, Mai Inagaki and Masanori Tachikawa :
ヒト胎盤栄養膜細胞(BeWo細胞)が分泌する細胞外小胞の分泌元細胞への再取り込み機構,
第16回次世代を担う若手のための医療薬科学シンポジウム, Oct. 2022.
25. Masanori Tachikawa and Mai Inagaki :
マイクロ流体デバイスを用いた三次元ヒト血液脳関門の再構築と特性解析,
第44回神経組織培養研究会, Sep. 2022.
26. 酒巻 祐花, Mai Inagaki, 佐藤 桃子, 中野 瑛介, 船本 健一 and Masanori Tachikawa :
マイクロ流体デバイスを用いた三次元血管網モデルの構築と胎盤由来細胞外小胞の動態可視化,
日本薬剤学会第37年会, May 2022.
27. 杉下 友香, Mai Inagaki, 馬渡 一諭, 小迫 英尊, 三宅 雅人, 親泊 政一 and Masanori Tachikawa :
ヒト脳血管内皮細胞(hCMEC/D3細胞)におけるCD147-トランスポーター複合体の役割,
日本薬剤学会第37年会, May 2022.
28. Masanori Tachikawa and Mai Inagaki :
ヒト血液脳関門における細胞外小胞輸送システムの多様性と特異性,
日本薬学会第142年会, Mar. 2022.
29. Momoko Sato, Mai Inagaki, YUKA Sakamaki, 船本 健一 and Masanori Tachikawa :
マイクロ流体デバイスを用いた三次元ヒト脳微小血管網の構築,
日本薬学会第142年会, Mar. 2022.
30. Masanori Tachikawa :
定量プロテオミクスが拓いた脳関門物流システム-Brain Barrier Logistics-解明研究,
第14回日本薬物動態学会ショートコース, Nov. 2021.
31. Masanori Tachikawa :
ヒト血液脳関門物流システムの解明と「脳関門創薬」,
北勢バイオコミュニティ研究会セミナー, Nov. 2021.
32. Mai Inagaki, Hinori Sano, Miku Inai, 赤沼 伸乙, 細谷 健一 and Masanori Tachikawa :
ヒト脳血管内皮細胞における胎盤栄養膜細胞から分泌される細胞外小胞の輸送特性,
第36回日本薬物動態学会, Nov. 2021.
33. Mai Inagaki, Tsukasa Sugiyama, Momoko Sato, 吉田 将人, 土井 隆行, 和田 敬仁, 新保 裕子, 露崎 悠, 後藤 知英, 寺崎 哲也 and Masanori Tachikawa :
ヒト血液脳関門モデルhCMEC/D3細胞におけるクレアチンプロドラッグの輸送特性,
第42回生体膜と薬物の相互作用シンポジウム, Oct. 2021.
34. 北風 圭介, 親泊 美帆, 張 君, 濱田 良真, 竹之内 康広, 坪井 一人, Mai Inagaki, Masanori Tachikawa, 藤谷 与士夫, 岡本 安雄 and 親泊 政一 :
ATF4を介した転写制御は小胞体ストレスによる膵β細胞の喪失を防ぐ,
第62回日本生化学会中国・四国支部例会, Sep. 2021.
35. Masanori Tachikawa :
A quantitative proteomics-based study to clarify a role of the blood-brain barrier as the interface between central nervus system and peripheral immune system.,
第44回日本神経科学会, Jul. 2021.
36. Mai Inagaki and Masanori Tachikawa :
胎盤治療の基盤としての胎盤関門・細胞外小胞輸送システム,
日本薬剤学会第36年会, May 2021.
37. Masanori Tachikawa and Mai Inagaki :
末梢から中枢への情報伝達制御装置としての血液脳関門物流システムの役割と脳への薬物送達,
日本薬剤学会第36年会, May 2021.
38. MIKU Inai, Mai Inagaki, 赤沼 伸乙, 細谷 健一 and Masanori Tachikawa :
マイクロRNAの妊娠マウス脳への分布とヒト脳血管内皮細胞における胎盤由来細胞外小胞を介した輸送,
日本薬剤学会第36年会, May 2021.
39. EISUKE Nakano, MIKU Inai, Mai Inagaki and Masanori Tachikawa :
ヒト胎盤栄養膜細胞(BeWo細胞)由来細胞外小胞の胎盤への再取り込み輸送機構の解明,
日本薬剤学会第36年会, May 2021.
40. HINORI Sano, MIKU Inai, Mai Inagaki and Masanori Tachikawa :
ヒト脳血管内皮細胞(hCMEC/D3細胞)におけるヒト胎盤絨毛細胞株BeWo細胞から分泌される細胞外小胞の輸送特性,
日本薬剤学会第36年会, May 2021.
41. YUKA Sakamaki, Mai Inagaki, Momoko Sato, 船本 健一 and Masanori Tachikawa :
マイクロ流体デバイスを用いた灌流性を有する三次元ヒト微小血管網の再構築,
日本薬剤学会第36年会, May 2021.
42. Tohru Kinoshita, Daiki Ohno, 小迫 英尊, Mai Inagaki and Masanori Tachikawa :
網羅的プロテオミクスを用いたヒト脳毛細血管内皮細胞への内在化活性を示す脳転移性メラノーマSK-Mel-28由来細胞外小胞の特性解析,
日本薬剤学会第36年会, May 2021.
43. Makoto Amifuji, 今野 源, 吉田 将人, 土井 隆行, Mai Inagaki, 寺崎 哲也 and Masanori Tachikawa :
中分子環状デプシペプチドDestruxin Eの細胞膜輸送・細胞内代謝・分子標的V-ATPase阻害における立体特異性の解明,
日本薬剤学会第36年会, May 2021.
44. Tsukasa Sugiyama, Mai Inagaki, Momoko Sato, 吉田 将人, 土井 隆行, 和田 敬仁, 新保 裕子, 露崎 悠, 後藤 知英, 寺崎 哲也 and Masanori Tachikawa :
ヒト脳血管内皮細胞におけるクレアチンプロドラッグのクレアチントランスポーター非依存的輸送の実証,
日本薬剤学会第36年会, May 2021.
45. Masanori Tachikawa :
網羅的定量プロテオミクスに基づくプラズマ生体作用の分子的解明,
仙台''プラズマフォーラム'', Mar. 2021.
46. Masanori Tachikawa :
定量プロテオミクスで解き明かす血液脳関門・血液くも膜関門,
第39回日本認知症学会学術集会, Nov. 2020.
47. Masanori Tachikawa :
Role of the blood-arachnoid barrier transport system as a brain clearance system.,
第43回日本神経科学会, Jul. 2020.
48. 網藤 惇, 今野 源, 吉田 将人, 土井 隆行, 内田 康雄, 臼井 拓也, 寺崎 哲也 and Masanori Tachikawa :
細胞膜輸送及び細胞内タンパク結合に着目した環状デプシペプチドDestruxinEの立体特異的な活性発現の要因解明,
日本薬剤学会第35年会, May 2020.
49. Mai Inagaki, 佐野 陽乃里, 中野 瑛介, 登美 斉俊 and Masanori Tachikawa :
ヒト胎盤絨毛細胞株BeWo細胞由来エクソソームのヒト脳血管内皮細胞 (hCMEC/D3)への内在化,
日本薬学会第141年会, Mar. 2020.
50. Masanori Tachikawa :
血液脳関門透過性タンパク質と脳血管内皮細胞における輸送特性,
日本薬物動態学会第34年会, Dec. 2019.
51. Masanori Tachikawa :
次世代型「脳関門創薬」拠点形成:ヒト血液-脳関門物流システム解明に基づく脳関門突破型抗体 ・核酸医薬の開発,
徳島大学研究クラスターシンポジウム, Nov. 2019.
52. Masanori Tachikawa :
定量プロテオミクスを基盤とした「脳関門創薬科学」研究,
第41回神経組織培養研究会, Nov. 2019.
53. Masanori Tachikawa :
中枢関門科学:Connecting the human dots,
第13回次世代を担う若手医療薬科学シンポジウム, Oct. 2019.
54. Masanori Tachikawa :
定量プロテオミクスを基盤としたがんエクソソームとヒト血液脳関門研究,
株式会社エービー・サイエックスランチョンセミナー, Aug. 2019.
55. Masanori Tachikawa :
ヒト血液脳関門における脳転移性メラノーマ由来エクソソームの輸送機構と種差,
日本薬学会第139年会, Mar. 2019.
56. Masanori Tachikawa :
定量プロテオミクスを基軸とした血液脳関門の攻略法:高分子輸送の分子機構とドラッグデリバリー,
富山大学和漢研セミナー (第416回), Feb. 2019.
57. Masanori Tachikawa :
定量プロテオミクスを基軸とする「脳関門中枢創薬科学」の新たな展開,
第24回創剤フォーラム若手研究会, Sep. 2018.

Et cetera, Workshop:

1. Masanori Tachikawa :
Decoding and manipulating of the human blood-brain barrier logistics for brain-targeting delivery of macromolecules,
Seminar at Uppsala University, Jun. 2023.
2. Masanori Tachikawa :
-,
日本薬物動態学会ニュースレター, Vol.36, No.4, Aug. 2021.
3. Masanori Tachikawa :
Advanced quantitative proteomics and its application to the Blood-Brain Barrier research.,
The University of British Columbia Faculty of Pharmaceutical Sciences Seminar, Nov. 2019.
4. Masanori Tachikawa :
創薬における一細胞解析の重要性と解析事例,
シングルセル解析の偉力を学ぶ''「拡大版ジャーナルクラブ」(徳島大学大学院医歯薬学研究部 総合研究支援センター先端医療研究部門), Aug. 2019.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Development of vascular permeability control method by integration of blood-brain barrier-on-a-chip and measurement-integrated simulation (Project/Area Number: 23K28409 )
  • 脳クレアチン供給を実現するモノカルボン酸輸送体認識型プロドラッグ開発とその有用性 (Project/Area Number: 23K27338 )
  • 金魚免疫系×ヒトモデル化血液脳関門チップで変革する中枢送達型抗体開発 (Project/Area Number: 22K19493 )
  • 脳血管-神経ユニット・胎盤エクソソーム輸送系を軸とした胎盤-脳連関機構解明と応用 (Project/Area Number: 23K24231 )
  • A novel model of multiple sclerosis and multiple system atrophy that are differentially manifested by the time of abnormal protein expression (Project/Area Number: 20K20470 )
  • Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification system (Project/Area Number: 19K22599 )
  • Investigation of the mechanism and prevention for ischemia-reperfusion injury by using blood-brain barrier-on-a-chip (Project/Area Number: 19H04435 )
  • Brain-targeting of exosomes based on the virus receptors-mediated transport at the human blood-brain barrier (Project/Area Number: 19H03390 )
  • Establishment of the basis for bioscience of short-lived reactive species using a new concept of gas-liquid interfacial plasma with high-speed liquid flow (Project/Area Number: 18H03687 )
  • Study of human brain barrier transport mechanism based global and targeted proteomics (Project/Area Number: 17H04004 )
  • Functional coupling of the blood-brain barrier and astrocytes in epilepsy (Project/Area Number: 16H01326 )
  • Investigation of contribution of novel tight junction molecule at the two big central nervous system barriers and its usefulness as a therapeutic target for multiple sclerosis (Project/Area Number: 16K15475 )
  • Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration. (Project/Area Number: 16K15157 )
  • Amino acid transporter-based drug development for cerebral creatine deficiency syndrome (Project/Area Number: 16K15153 )
  • Development of order-made therapy for pancreatic cancer controlling of crosstalk between cancer cell and cancer associated fibroblast (Project/Area Number: 16K10588 )
  • Transport systems at the arachnoid barrier cells-forming blood-cerebrospinal fluid barrier. (Project/Area Number: 16K08364 )
  • Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange (Project/Area Number: 15K21729 )
  • Elucidation of molecular mechanism in liver metastasis of gastroenteropancreatic neuroendocrine tumors (Project/Area Number: 15K10179 )
  • Screening and analysis of glial factors for neuroprotection (Project/Area Number: 15H05648 )
  • Study for Pathogenesis of Cerebral Creatine Deficiency Syndromes (Project/Area Number: 26461544 )
  • Early protein restriction impacts gene/protein expression and function in mature brain (Project/Area Number: 26292071 )
  • Retrieval of blood-brain barrier transport function towards dementia prevention (Project/Area Number: 25670067 )
  • Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseases (Project/Area Number: 24659072 )
  • Quantitative targeted absolute proteomics-based diagnostics for personalized cancer chemotherapy (Project/Area Number: 24659063 )
  • Development of order-made therapy for pancreatic cancer based on quantitative proteomics and metabolomics archive (Project/Area Number: 24592018 )
  • Clarification of molecular mechanisms of the blood-brain barrier plasticity based on quantitative targeted absolute proteomics (Project/Area Number: 24249011 )
  • Pathophysiological role of the blood-brain barrier hemichannels and molecular-targeted diagnosis and therapy (Project/Area Number: 22689005 )
  • Molecular identification and physiological role of brain-type prostaglandin transporter (Project/Area Number: 21390042 )
  • アミノ酸トランスポーター遺伝子の転写活性調節による網膜血管新生阻害法の開発 (Project/Area Number: 19659035 )
  • 脳関門輸送系による痙攣誘発性物質の中枢障害回避機構 (Project/Area Number: 18790115 )
  • Physiological role of retina-to-blood efflux transport at the inner blood-retinal barrier (Project/Area Number: 18390048 )
  • Search by Researcher Number (00401810)