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Research Activity

Field of Study

Subject of Study

Book / Paper

Proceeding of Domestic Conference:

1. Masanori Tachikawa :
ヒト血液脳関門における脳転移性メラノーマ由来エクソソームの輸送機構と種差,
日本薬学会第139年会, Mar. 2019.
2. Masanori Tachikawa :
定量プロテオミクスを基軸とした血液脳関門の攻略法:高分子輸送の分子機構とドラッグデリバリー,
富山大学和漢研セミナー (第416回), Feb. 2019.
3. Masanori Tachikawa :
定量プロテオミクスを基軸とする「脳関門中枢創薬科学」の新たな展開,
第24回創剤フォーラム若手研究会, Sep. 2018.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 「血液くも膜関門排出輸送に基づく中枢解毒」仮説の実証研究 (Project/Area Number: 19K22599 )
  • 異常蛋白発現時期により多発性硬化症から多系統萎縮症へ移行する新モデルとグリア治療 (Project/Area Number: 19H05562 )
  • Investigation of the mechanism and prevention for ischemia-reperfusion injury by using blood-brain barrier-on-a-chip (Project/Area Number: 19H04435 )
  • ヒトウイルス受容体を介した血液脳関門突破機構に基づくエクソソームの脳細胞標的化 (Project/Area Number: 19H03390 )
  • 新概念高速液流気液界面プラズマによる短寿命活性種バイオサイエンスの基盤確立 (Project/Area Number: 18H03687 )
  • Study of human brain barrier transport mechanism based global and targeted proteomics (Project/Area Number: 17H04004 )
  • Functional coupling of the blood-brain barrier and astrocytes in epilepsy (Project/Area Number: 16H01326 )
  • Investigation of contribution of novel tight junction molecule at the two big central nervous system barriers and its usefulness as a therapeutic target for multiple sclerosis (Project/Area Number: 16K15475 )
  • Evaluation of Cx43 proteins for PGE2 release from retinal pigment epithelial cells for understanding the pathological role in age-related macular degeneration. (Project/Area Number: 16K15157 )
  • Amino acid transporter-based drug development for cerebral creatine deficiency syndrome (Project/Area Number: 16K15153 )
  • 膵癌細胞-癌間質線維芽細胞クロストーク制御による膵癌オーダーメイド治療法の開発 (Project/Area Number: 16K10588 )
  • アラクノイドバリアー上皮細胞を実体とする血液脳脊髄液関門の輸送機構解明 (Project/Area Number: 16K08364 )
  • Project to create international glial researcher network: mainly focusing on Japan-Germany research exchange (Project/Area Number: 15K21729 )
  • Elucidation of molecular mechanism in liver metastasis of gastroenteropancreatic neuroendocrine tumors (Project/Area Number: 15K10179 )
  • Screening and analysis of glial factors for neuroprotection (Project/Area Number: 15H05648 )
  • Study for Pathogenesis of Cerebral Creatine Deficiency Syndromes (Project/Area Number: 26461544 )
  • Early protein restriction impacts gene/protein expression and function in mature brain (Project/Area Number: 26292071 )
  • Retrieval of blood-brain barrier transport function towards dementia prevention (Project/Area Number: 25670067 )
  • Molecular mechanisms of prostaglandin elimination across brain barriers and its application to neural inflammatory diseases (Project/Area Number: 24659072 )
  • Quantitative targeted absolute proteomics-based diagnostics for personalized cancer chemotherapy (Project/Area Number: 24659063 )
  • Development of order-made therapy for pancreatic cancer based on quantitative proteomics and metabolomics archive (Project/Area Number: 24592018 )
  • Clarification of molecular mechanisms of the blood-brain barrier plasticity based on quantitative targeted absolute proteomics (Project/Area Number: 24249011 )
  • Pathophysiological role of the blood-brain barrier hemichannels and molecular-targeted diagnosis and therapy (Project/Area Number: 22689005 )
  • Molecular identification and physiological role of brain-type prostaglandin transporter (Project/Area Number: 21390042 )
  • アミノ酸トランスポーター遺伝子の転写活性調節による網膜血管新生阻害法の開発 (Project/Area Number: 19659035 )
  • 脳関門輸送系による痙攣誘発性物質の中枢障害回避機構 (Project/Area Number: 18790115 )
  • Physiological role of retina-to-blood efflux transport at the inner blood-retinal barrier (Project/Area Number: 18390048 )
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