Tokushima University / Educator and Researcher Directory --- Ito, Hiroyuki

Field of Study

Subject of Study

Book / Paper

Book:

1.	Hiroyuki Ito and Hirotsugu Yamada : Ⅴ心臓疾患心膜炎の分類と疫学, Sep. 2019.
2.	Hiroyuki Ito and Hirotsugu Yamada : 心膜炎の分類と疫学, 2019.

Academic Paper (Judged Full Paper):

1.	Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Y Tsuruo and Masataka Sata : Association of Microluminal Structures Assessed by Optical Coherence Tomography With Local Inflammation in Adjacent Epicardial Adipose Tissue and Coronary Plaque Characteristics in Fresh Cadavers, Circulation Journal, Vol.87, No.2, 329-335, 2023. (Summary) Coronary intraplaque microluminal structures (MS) are associated with plaque vulnerability, and the inward progression of vascular inflammation from the adventitia towards the media and intima has also been demonstrated. Therefore, in the present study we investigated the relationships among MS, local inflammation in adjacent epicardial adipose tissue (EAT), and coronary plaque characteristics.Methods and Results: Optical coherence tomography (OCT) revealed MS in the left anterior descending coronary artery in 10 fresh cadaveric hearts. We sampled 30 lesions and subdivided them based on the presence of MS: MS (+) group (n=19) and MS (-) group (n=11). We measured inflammatory molecule levels in the adjacent EAT and percentage lipid volume assessed by integrated backscatter intravascular ultrasound in each lesion. The expression levels of vascular endothelial growth factor B and C-C motif chemokine ligand 2 were significantly higher in the MS (+) group than in the MS (-) group (0.9±0.7 vs. 0.2±0.2 arbitrary units (AU), P=0.04 and 1.5±0.5 vs. 0.6±0.7 AU, P=0.02, respectively). Percentage lipid volume was significantly higher in the MS (+) group than in the MS (-) group (38.7±16.5 vs. 23.7±10.9%, P=0.03). Intraplaque MS observed on OCT were associated with lipid-rich plaques and local inflammation in the adjacent EAT. Collectively, these results suggest that local inflammation in the EAT is associated with coronary plaque vulnerability via MS. (Tokushima University Institutional Repository) ● Metadata: 117602 (Link to Publication Site) ● Publication site (DOI): 10.1253/circj.CJ-22-0299 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36244741 ● Search Scopus @ Elsevier (PMID): 36244741 ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-22-0299 (Tokushima University Institutional Repository: 117602, DOI: 10.1253/circj.CJ-22-0299, PubMed: 36244741)
2.	Yutaka Kawabata, Takeshi Soeki, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki, M Kitani, K Kawano, Y Taketani and Masataka Sata : Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II-Renin Feedback in Hypertensive Patients, International Journal of Hypertension, 6653851, 2020. (Tokushima University Institutional Repository) ● Metadata: 115937 (Link to Publication Site) ● Publication site (DOI): 10.1155/2020/6653851 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33489354 ● Summary page in Scopus @ Elsevier: 2-s2.0-85098701678 (Tokushima University Institutional Repository: 115937, DOI: 10.1155/2020/6653851, PubMed: 33489354, Elsevier: Scopus)
3.	Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Yoshihiro Tsuruo and Masataka Sata : Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers, Circulation Journal, Vol.84, No.5, 769-775, 2020. (Tokushima University Institutional Repository) ● Metadata: 116640 (Link to Publication Site) ● Publication site (DOI): 10.1253/circj.CJ-19-0914 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32281556 ● Summary page in Scopus @ Elsevier: 2-s2.0-85083919450 (Tokushima University Institutional Repository: 116640, DOI: 10.1253/circj.CJ-19-0914, PubMed: 32281556, Elsevier: Scopus)
4.	Shusuke Yagi, Daisuke Kondo, Takayuki Ise, Daiju Fukuda, Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, Yoshihito Saijo, Hiromitsu Seno, Kumiko Sutou, Rie Ueno, Takafumi Todoroki, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Hirotsugu Yamada, Takeshi Soeki, Michio Shimabukuro, Ken-ichi Aihara, Masashi Akaike and Masataka Sata : Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome, Journal of Atherosclerosis and Thrombosis, Vol.26, No.3, 272-281, 2019. (Summary) It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, the data available on the effects of statin therapy on the serum levels of PUFA and the subsequent impact on in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited. A total of 120 ACS patients who received emergent coronary stent implantation, follow-up coronary angiography to evaluate ISR, and new statin therapy were enrolled. We measured the serum levels of the PUFA and lipids at the onset of ACS and at the follow-up coronary angiography. The follow-up coronary angiography revealed 38 ISR cases. New statin therapy significantly reduced the serum levels of DHA and low-density lipoprotein cholesterol (LDL-C), while it did not affect EPA level. Single regression analysis revealed that a decreased serum level of LDL-C was associated with decreased DHA level. The multiple logistic regression analysis revealed that the decreased DHA level after statin therapy and low serum level of EPA on admission were determinants of prevalence of ISR. Statin therapy decreased the serum level of DHA with a parallel reduction in LDL-C level in patients with ACS. Decreased DHA level after statin therapy and low EPA level on admission are risk factors for ISR, indicating that in patients with ACS, decreased serum levels of DHA may be a residual target for the prevention of ISR. (Keyword) Acute Coronary Syndrome / Aged / Coronary Restenosis / Docosahexaenoic Acids / Eicosapentaenoic Acid / female / Follow-Up Studies / Humans / Hydroxymethylglutaryl-CoA Reductase Inhibitors / male / Prognosis / Retrospective Studies / Risk Factors / Stents (Tokushima University Institutional Repository) ● Metadata: 113220 (Link to Publication Site) ● Publication site (DOI): 10.5551/jat.44735 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30135329 ● Summary page in Scopus @ Elsevier: 2-s2.0-85062425735 (Tokushima University Institutional Repository: 113220, DOI: 10.5551/jat.44735, PubMed: 30135329, Elsevier: Scopus)
5.	Mina Takahashi, Takeshi Tobiume, Kazuhisa Matsumoto, Tomomi Matsuura, Takeshi Soeki, 藤本裕太, 原田貴文, Zengu Robahto, 數藤久美子, 西條良仁, 上野理絵, Yutaka Kawabata, Mika Bando, nao Yamada, Hiroyuki Ito, 轟貴史, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata : A successful case of catheter ablation against ventricular tachycardia storm due to old myocardial infarction in a patient with aortic valve replacement, Shikoku Acta Medica, Vol.74, No.56, 201-208, 2019. (Summary) A 68-year-old woman with VT storm and frequent appropriate ICD therapy was referred for catheter ablation. Her past history was notable for aortic valve replacement by mechanical valve due to infectious endocarditis 17 years prior to presentation and left ventricular apical old myocardial infarction with unknown onset. At 67 years old, She admitted to the prior hospital due to ventricular tachycardia with LBBB and superior axis at heart rate of 210 per minutes. Administration of amiodarone and magnesium sulfate was ineffective and cardioversion of 200J was successfully terminated the tachycardia. Intra-cardiac defibrillator was implanted and the administration of amiodarone and mexiletine was started. 5 months after, she admitted to the hospital due to the frequent appropriate shock against the same ventricular tachycardia. Administration of lidocaine, sotalol, pilsicainide, and magnesium sulfate could not control the tachycardia and she was referred to our hospital for catheter ablation. During the first session, ventricular tachycardia was easily induced and electroanatomical mapping was performed both during tachycardia and during sinus rhythm. Late diastolic potential preceding the onset of QRS wave by 45ms was detected at the infero-septal side of the apical aneurysm. 7 5s of the RF energy application at this site could terminate the tachycardia and thereafter no ventricular tachycardia was induced. But after dose-reduction or cessation of some anti-arrhythmic drugs, ventricular tachycardia was recurred and second session was performed. This time, no ventricular tachycardia was induced, then we performed isthmus transection and core isolation against the apical aneurysm. Thereafter no ventricular tachycardia was occurred in spite of dose-reduction or cessation of some anti-arrhythmic drugs. (Keyword) ventricular tachycardia / storm / old myocardial infarction / catheter ablation / aortic valve replacement (Tokushima University Institutional Repository) ● Metadata: 112988 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050001338015711104 (Tokushima University Institutional Repository: 112988, CiNii: 1050001338015711104)

Proceeding of Domestic Conference:

1.	Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Hiroyuki Ito, Takayuki Ise, Kenya Kusunose, Tomomi Matsuura, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : 光干渉断層法で観察される冠動脈壁微小管腔構造と局所冠動脈周囲脂肪内炎症および冠動脈プラークの関連 -未固定遺体における検討-, Beyond Angiography Japan XXV, Mar. 2021.
2.	Yutaka Kawabata, Tetsuzo Wakatsuki, Koji Yamaguchi, Hiroyuki Ito, Ueno Rie, Takayuki Ise, Todoroki Takashi, Takeshi Tobiume and Masataka Sata : Relationship between coronary intraplaque microluminal structures and local inflammation in adjacent epicardial adipose tissue - A fresh cadaveric study, 第28回日本心血管インターベンション治療学会, Sep. 2019.
3.	木田貴弘, Takeshi Tobiume, 松本和久, 坂東左知子, Tomomi Matsuura, Takeshi Soeki, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, Mika Bando, 山田なお, Hiroyuki Ito, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata : 房室ブロックの進行に伴い明らかになり，恒久的ペースメーカー植込み術後のファーフィールドR波センシングへの関与が疑われた束枝心室間副伝導路の1例, 第259回徳島医学会学術集会, Aug. 2019.
4.	井口裕貴, Takeshi Tobiume, 松本和久, 坂東左知子, Tomomi Matsuura, Takeshi Soeki, 志村拓哉, 髙橋智子, 谷彰浩, 藤本裕太, 大櫛祐一郎, 數藤久美子, 髙橋智紀, 上野理絵, 門田宗之, 川端豊, Mika Bando, 山田なお, Hiroyuki Ito, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata : 房室ブロックの予防に順行性速伝導路と順行性遅伝導路のマッピングが有用であった順行性速伝導路の下方偏位を伴う遅速型房室結節リエントリー性頻拍の1例, 第259回徳島医学会学術集会, Aug. 2019.
5.	志村拓哉, Takayuki Ise, 川端豊, 藤本裕太, 松本和久, 上野理絵, 山田なお, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Hirotsugu Kurobe, Eiki Fujimoto and Masataka Sata : 先天性二尖弁に対するTAVIの2例, 第114回日本循環器学会中国・四国合同地方会, Jun. 2019.
6.	中村昌史, 川端豊, Takayuki Ise, 藤本裕太, 原田貴文, 松本和久, 西條良仁, 上野理絵, 山田なお, Hiroyuki Ito, 轟貴史, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Daiju Fukuda, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : 経食道心エコーガイド下の経皮的腫瘍生検により早期に診断し得た心臓原発血管肉腫の一例, 第114回日本循環器学会中国・四国合同地方会, Jun. 2019.
7.	Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, 川端豊, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Microluminal structures of coronary plaque and vasa vasorums affect coronary inflammation: A fresh cadaveric studys, 第83回日本循環器学会学術集会, Mar. 2019.
8.	川端豊, Tetsuzo Wakatsuki, Koji Yamaguchi, Hiroyuki Ito, Daiju Fukuda, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Coronary intraplaque microluminal structure are associated with the quality and quantity of epicardial adipose tissue -A fresh cadaveric stury-, 第83回日本循環器学会学術集会, Mar. 2019.
9.	藤本裕太, Kenya Kusunose, 西條良仁, Zheng Robert, 原田貴文, 松本和久, 上野理絵, 川端豊, 山田なお, Hiroyuki Ito, 轟貴史, Takayuki Ise, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Hirotsugu Kurobe and Masataka Sata : Staphylococcus による感染性内膜炎の一例, 第113回日本循環器学会四国合同地方会, Dec. 2018.
10.	Zheng Robert, Takayuki Ise, 川端豊, Shusuke Yagi, 西條良仁, 上野理絵, Mika Bando, Hiroyuki Ito, 轟貴史, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Hirotsugu Kurobe, Eiki Fujimoto, Tetsuya Kitagawa and Masataka Sata : Single coronary 合併重症ASに対してTAVIを施行し救命し得た1例, 第113回日本循環器学会四国合同地方会, Dec. 2018.
11.	Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, Takayuki Ise, Kenya Kusunose, Tomomi Matsuura, Takafumi Todoroki, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : 未固定遺体における冠動脈壁小管腔構造と局所心臓周囲脂肪内炎症との関連, 第66回日本心臓病学会学術集会, Sep. 2018.
12.	Koji Yamaguchi, Tetsuzo Wakatsuki, Yoshihito Saijoh, 上野理絵, Yutaka Kawabata, Mika Bando, Hiroyuki Ito, Takafumi Todoroki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : 第三世代薬剤溶出性ステント留置後における局所凝固反応塗装ステント長の関連性, 第66回日本心臓病学会学術集会, Sep. 2018.
13.	Hiroyuki Ito, Takeshi Soeki, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Tetsuzo Wakatsuki and Masataka Sata : AVNRTアブレーション治療後に発生したJunctional Tachycardiaの1例, 第112回日本循環器学会中国・四国合同地方会, Jun. 2018.
14.	Takafumi Todoroki, Tetsuzo Wakatsuki, Koji Yamaguchi, Seno Hiromitsu, Kumiko Sutou, Yoshihito Saijoh, Yutaka Kawabata, 上野理絵, Hiroyuki Ito, Tomomi Matsuura, Kenya Kusunose, Takayuki Ise, Takeshi Tobiume, Shusuke Yagi, Daiju Fukuda, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : EES留置3年後，術前に抗血小板剤中止しペパリン置換したにもかかわらず2枝同時ステント閉塞を起こした1例, 第112回日本循環器学会中国・四国合同地方会, Jun. 2018.
15.	Susumu Nishio, Kenya Kusunose, 平田有紀奈, 鳥居裕太, 天野里江, 山尾雅美, Hiroyuki Ito, Takayuki Ise, Koji Yamaguchi, Tetsuzo Wakatsuki, Hirotsugu Yamada and Masataka Sata : 左上肢の脱力で脳卒中センターへ搬送された急性冠症候群の1例, Japanese Journal of Medical Ultrasound Technology, Vol.43, No.3, 363, Jun. 2018.
16.	Takayuki Ise, Shusuke Yagi, Yutaka Kawabata, Seno Hiromitsu, Kumiko Sutou, Yoshihito Saijoh, Rie Ueno, Hiroyuki Ito, Takafumi Todoroki, Tomomi Matsuura, Kenya Kusunose, Takeshi Tobiume, Koji Yamaguchi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki and Masataka Sata : Acute Hemodynamic Effect of Handgrip Stress in Patients with Chronic Heart Failure., 第82回日本循環器学会, Mar. 2018.
17.	Hiroyuki Ito, Kenya Kusunose, Hirotsugu Yamada, Hiromitsu Seno, Yoshihito Saijoh, Susumu Nishio, Yukina Hirata and Masataka Sata : Association of Left Ventricular Diastolic Function using American Society of Echocardiography Recommendation with Readmission in Patients with Heart Failure., 第82回日本循環器学会, Mar. 2018.
18.	Hiroyuki Ito, Tetsuzo Wakatsuki, Koji Yamaguchi, Daiju Fukuda, Yutaka Kawabata, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Growth of Vasa Vasorum is Associated with Local Inflammation around Coronary Plaque in Fresh Cadavers(和訳中), 日本循環器学会学術集会抄録集, PJ007-3, Mar. 2018.
19.	Koji Yamaguchi, Tetsuzo Wakatsuki, Yutaka Kawabata, Hiroyuki Ito, 轟貴史, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Takeshi Tobiume, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki and Masataka Sata : Differential Response of Local Coagulation after Coronary Angioplasty with Paclitaxel(和訳中), 日本循環器学会学術集会抄録集, PJ022-1, Mar. 2018.
20.	Shusuke Yagi, Takayuki Ise, Yutaka Kawabata, Hiroyuki Ito, Kenya Kusunose, Koji Yamaguchi, Hirotsugu Yamada, Tetsuzo Wakatsuki, Masashi Akaike and Masataka Sata : 経カテーテル大動脈弁植込み術を施した超高齢大動脈弁狭窄症の1例, 日本老年医学会四国地方会, Feb. 2018.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

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Designated Assistant Professor : Ito, Hiroyuki

Research

Field of Study

Subject of Study

Book / Paper

Book:

Academic Paper (Judged Full Paper):

Proceeding of Domestic Conference:

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)