Tokushima University / Educator and Researcher Directory --- Kajisa, Taira

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○	Life sciences [Biomedical engineering]

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Academic Paper (Judged Full Paper):

1.	Shogo Miyamura, Ryo Oe, Takuya Nakahara, Hidenori Koresawa, Shota Okada, Shuji Taue, Yu Tokizane, Takeo Minamikawa, Kunihiro Otsuka, Ayuko Sakane, Takuya Sasaki, Koji Yasutomo, Taira Kajisa and Takeshi Yasui : Rapid, high-sensitivity detection of biomolecules using dual-comb biosensing, Scientific Reports, Vol.13, 14541, 2023. (Summary) Rapid, sensitive detection of biomolecules is important for biosensing of infectious pathogens as well as biomarkers and pollutants. For example, biosensing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still strongly required for the fight against coronavirus disease 2019 (COVID-19) pandemic. Here, we aim to achieve the rapid and sensitive detection of SARS-CoV-2 nucleocapsid protein antigen by enhancing the performance of optical biosensing based on optical frequency combs (OFC). The virus-concentration-dependent optical spectrum shift produced by antigen-antibody interactions is transformed into a photonic radio-frequency (RF) shift by a frequency conversion between the optical and RF regions in the OFC, facilitating rapid and sensitive detection with well-established electrical frequency measurements. Furthermore, active-dummy temperature-drift compensation with a dual-comb configuration enables the very small change in the virus-concentration-dependent signal to be extracted from the large, variable background signal caused by temperature disturbance. The achieved performance of dual-comb biosensing will greatly enhance the applicability of biosensors to viruses, biomarkers, environmental hormones, and so on. (Keyword) Humans / COVID-19 / SARS-CoV-2 / COVID-19 Testing / Biosensing Techniques / Viruses / Antigens, Viral (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-023-41436-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37752134 ● Search Scopus @ Elsevier (PMID): 37752134 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-023-41436-3 (DOI: 10.1038/s41598-023-41436-3, PubMed: 37752134)
2.	Hidenori Koresawa, Kohta Seki, Kenji Nishimoto, Eiji Hase, Yu Tokizane, Taka-aki Yano, Taira Kajisa, Takeo Minamikawa and Takeshi Yasui : Real-time hybrid angular-interrogation surface plasmon resonance sensor in the near-infrared region for wide dynamic range refractive index sensing, Scientific Reports, Vol.13, 15655, 2023. (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-023-42873-w (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85171656857 (DOI: 10.1038/s41598-023-42873-w, Elsevier: Scopus)
3.	Taira Kajisa, Taka-aki Yano, Hidenori Koresawa, Kunihiro Otsuka, Ayuko Sakane, Takuya Sasaki, Koji Yasutomo and Takeshi Yasui : Highly sensitive detection of nucleocapsid protein from SARS-CoV-2 using a near-infrared surface plasmon resonance sensing system, Optics Continuum, Vol.11, No.1, 2336-2346, 2022. (Link to Publication Site) ● Publication site (DOI): 10.1364/OPTCON.472486 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1364/OPTCON.472486 (DOI: 10.1364/OPTCON.472486)
4.	Hidenori Koresawa, Kohta Seki, Eiji Hase, Yu Tokizane, Takeo Minamikawa, Taka-aki Yano, Taira Kajisa and Takeshi Yasui : Beam-angle-scanning surface plasmon resonance sensor for rapid, high-precision sensing of refractive index and bio-molecules, Optics Continuum, Vol.1, No.3, 565-574, 2022. (Link to Publication Site) ● Publication site (DOI): 10.1364/OPTCON.451947 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1364/OPTCON.451947 (DOI: 10.1364/OPTCON.451947)
5.	Taka-aki Yano, Taira Kajisa, Masayuki Ono, Yoshiya Miyasaka, Yuichi Hasegawa, Atsushi Saito, Kunihiro Otsuka, Ayuko Sakane, Takuya Sasaki, Koji Yasutomo, Rina Hamajima, Yuta Kanai, Takeshi Kobayashi, Yoshiharu Matsuura, Makoto Itonaga and Takeshi Yasui : Ultrasensitive detection of SARS-CoV-2 nucleocapsid protein using large gold nanoparticle-enhanced surface plasmon resonance., Scientific Reports, Vol.12, No.1, 1060, 2022. (Summary) The COVID-19 pandemic has created urgent demand for rapid detection of the SARS-CoV-2 coronavirus. Herein, we report highly sensitive detection of SARS-CoV-2 nucleocapsid protein (N protein) using nanoparticle-enhanced surface plasmon resonance (SPR) techniques. A crucial plasmonic role in significantly enhancing the limit of detection (LOD) is revealed for exceptionally large gold nanoparticles (AuNPs) with diameters of hundreds of nm. SPR enhanced by these large nanoparticles lowered the LOD of SARS-CoV-2 N protein to 85 fM, resulting in the highest SPR detection sensitivity ever obtained for SARS-CoV-2 N protein. (Keyword) Coronavirus Nucleocapsid Proteins / Gold / Metal Nanoparticles / Phosphoproteins / SARS-CoV-2 / Surface Plasmon Resonance (Tokushima University Institutional Repository) ● Metadata: 117264 (Link to Publication Site) ● Publication site (DOI): 10.1038/s41598-022-05036-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35058513 ● Search Scopus @ Elsevier (PMID): 35058513 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-022-05036-x (Tokushima University Institutional Repository: 117264, DOI: 10.1038/s41598-022-05036-x, PubMed: 35058513)
6.	Taira Kajisa and Toshiya Sakata : Molecularly Imprinted Artificial Biointerface for an Enzyme-Free Glucose Transistor., ACS Applied Materials & Interfaces, Vol.10, No.41, 34983-34990, 2018. (Summary) obtained by nonelectrical detection methods. Moreover, the GluMIP-coated gate FET sensor shows an approximately 200-fold higher selectivity for glucose than for fructose. This is because glucose binds to PBA more selectively than fructose in the templates, resulting in the generation of negative charges. The electrical properties of the MIP-coated electrode are also evaluated by measuring capacitance. Our work suggests a new strategy of designing a platform based on the MIP-coated gate FET biosensor, which is suitable for a highly selective, sensitive, enzyme-free biosensing system. (Keyword) Biosensing Techniques / Boronic Acids / Electrochemical Techniques / Electrodes / glucose / Molecular Imprinting (Link to Publication Site) ● Publication site (DOI): 10.1021/acsami.8b13317 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30234958 ● Summary page in Scopus @ Elsevier: 2-s2.0-85055121997 (DOI: 10.1021/acsami.8b13317, PubMed: 30234958, Elsevier: Scopus)
7.	Taira Kajisa, Wei Li, Tsuyoshi Michinobu and Toshiya Sakata : Well-designed dopamine-imprinted polymer interface for selective and quantitative dopamine detection among catecholamines using a potentiometric biosensor., Biosensors and Bioelectronics, Vol.117, 810-817, 2018. (Summary) We report a well-designed biointerface enabling the selective and quantitative detection of dopamine (DA) using a potentiometric biosensor. To enhance the detection selectivity of DA, a DA-templated molecularly imprinted polymer (DA-MIP) was synthesized on the extended Au gate electrode of a field-effect transistor (FET) biosensor. For a quantitative DA analysis, the thickness of the DA-MIP was controlled to ca. 60 nm by surface-initiated atom transfer radical polymerization (SI-ATRP). In this process, the DA-MIP was copolymerized with vinylphenylboronic acid (vinyl-PBA), inducing molecular charges at the biointerface of the FET gate electrode. These charges were generated by the diol-binding between PBA and dopamine (a catecholamine), and were directly detected as a change in surface potential. In fact, the surface potential at the gate of the DA-MIP-coated FET responded significantly to DA added at concentrations ranging from 40 nM to 20 μM, whereas that of a non-imprinted polymer (NIP)-coated FET hardly changed over this range. Moreover, by measuring the kinetic parameters and electrochemical properties of well-designed devices with various added catecholamines, we confirmed that the DA-MIP-coated FET biosensor selectively and quantitatively detects DA. (Keyword) Biosensing Techniques / Catecholamines / dopamine / Electrochemical Techniques / Equipment Design / Gold / Molecular Imprinting / polymerization / Polymers / surface properties / thermodynamics (Tokushima University Institutional Repository) ● Metadata: 114473 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bios.2018.07.014 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30096735 ● Summary page in Scopus @ Elsevier: 2-s2.0-85049968531 (Tokushima University Institutional Repository: 114473, DOI: 10.1016/j.bios.2018.07.014, PubMed: 30096735, Elsevier: Scopus)
8.	Taira Kajisa, Wei Li and Tsuyoshi Michinobu : Catecholamine Detection Using a Functionalized Poly(l-dopa)-Coated Gate Field-Effect Transistor., ACS Omega, Vol.3, No.6, 6719-6727, 2018. (Summary) ): 182 mV). Moreover, the limit of detection for each CA was 3.5 nM in LD, 12.0 nM in DA, 7.5 nM in NE, and 12.6 nM in EP. From these results, it is concluded that the poly(PBA-LD/LD)-coated gate FET could become a useful biosensor for neurotransmitters, hormones, and early detection of Parkinson's disease. (Tokushima University Institutional Repository) ● Metadata: 114474 (Link to Publication Site) ● Publication site (DOI): 10.1021/acsomega.8b00518 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30023958 ● Summary page in Scopus @ Elsevier: 2-s2.0-85048928715 (Tokushima University Institutional Repository: 114474, DOI: 10.1021/acsomega.8b00518, PubMed: 30023958, Elsevier: Scopus)
9.	Taira Kajisa, Yoshiyuki Yanagimoto, Akiko Saito and Toshiya Sakata : Biocompatible Poly(catecholamine)-Film Electrode for Potentiometric Cell Sensing., ACS Sensors, Vol.3, No.2, 476-483, 2018. (Summary) ) and proteins such as albumin. Thus, the pCA-film electrodes can be used in pH-sensitive and pH-selective biosensors. HeLa cells were cultivated on the surface of the pCA-film electrodes to monitor cellular activities. The surface potential of the pCA-film electrodes changed markedly because of cellular activity; therefore, the change in the hydrogen ion concentration around the cell/pCA-film interface could be monitored in real time. This was caused by carbon dioxide or lactic acid that is generated by cellular respiration and dissolves in the culture medium, resulting in the change of hydrogen concentration. pCA-film electrodes are suitable for use in biocompatible and pH-responsive biosensors, enabling the more selective detection of biological phenomena. (Keyword) Biosensing Techniques / Catecholamines / Cell Culture Techniques / Coated Materials, Biocompatible / Electrodes / Gold / HeLa Cells / Humans / Hydrogen-Ion Concentration / Polymers / Potentiometry / surface properties (Tokushima University Institutional Repository) ● Metadata: 114475 (Link to Publication Site) ● Publication site (DOI): 10.1021/acssensors.7b00897 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29359919 ● Search Scopus @ Elsevier (PMID): 29359919 ● Search Scopus @ Elsevier (DOI): 10.1021/acssensors.7b00897 (Tokushima University Institutional Repository: 114475, DOI: 10.1021/acssensors.7b00897, PubMed: 29359919)
10.	Haoyue Yang, Masatoshi Honda, Akiko Saito, Taira Kajisa, Yuhki Yanase and Toshiya Sakata : Nonoptical Detection of Allergic Response with a Cell-Coupled Gate Field-Effect Transistor., Analytical Chemistry, Vol.89, No.23, 12918-12923, 2017. (Summary) ) with hydroxyl groups is fully responsive to pH on the basis of the equilibrium reaction. The allergic response of RBL-2H3 cells on the gate was also confirmed by estimating the amount of β-hexosaminidase released together with histamine and was analyzed using the electrical properties based on an inflammatory response of secreted histamine with the vascular endothelial cell-based FET. Thus, the allergic responses were monitored in a nonoptical and real-time manner using the cell-based FETs with the cellular layers on the gate, which reproduced the in vivo system and were useful for the reliable detection of the allergic reaction. (Keyword) Animals / Cell Line, Tumor / Cells, Immobilized / Electrochemical Techniques / histamine / Human Umbilical Vein Endothelial Cells / Humans / Hydrogen-Ion Concentration / Hypersensitivity / Immunoglobulin E / Oxides / Rats / Tantalum / Transistors, Electronic (Link to Publication Site) ● Publication site (DOI): 10.1021/acs.analchem.7b03688 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29116752 ● Search Scopus @ Elsevier (PMID): 29116752 ● Search Scopus @ Elsevier (DOI): 10.1021/acs.analchem.7b03688 (DOI: 10.1021/acs.analchem.7b03688, PubMed: 29116752)
11.	Toshiya Sakata, Kotaro Nishimura, Yuuya Miyazawa, Akiko Saito, Hiroyuki Abe and Taira Kajisa : Ion Sensitive Transparent-Gate Transistor for Visible Cell Sensing., Analytical Chemistry, Vol.89, No.7, 3901-3908, 2017. (Summary) film gate that includes an indium tin oxide (ITO) film as the source and drain electrodes is utilized. The pH response of the IS-TGT was found to be about 56 mV/pH, indicating approximately Nernstian response. Moreover, the potential signals of the IS-TGT for sodium and potassium ions, which are usually included in biological environments, were evaluated. The optical and electrical properties of the IS-TGT enable cell functions to be monitored simultaneously with microscopic observation and electrical measurement. A platform based on the IS-TGT can be used as a simple and cost-effective plate-cell-sensing system based on thin-film fabrication technology in the research field of life science. (Keyword) Electrodes / Gallium / HeLa Cells / Humans / Hydrogen-Ion Concentration / Indium / Ions / Oxides / Particle Size / potassium / Sodium / surface properties / Tin Compounds / Transistors, Electronic / Tumor Cells, Cultured / zinc (Link to Publication Site) ● Publication site (DOI): 10.1021/acs.analchem.6b02246 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28298088 ● Summary page in Scopus @ Elsevier: 2-s2.0-85019720126 (DOI: 10.1021/acs.analchem.6b02246, PubMed: 28298088, Elsevier: Scopus)
12.	Taira Kajisa and Toshiya Sakata : Glucose-responsive hydrogel electrode for biocompatible glucose transistor., Science and Technology of Advanced Materials, Vol.18, No.1, 26-33, 2017. (Summary) applications such as eye contact lenses and sheets adhering to the skin. (Tokushima University Institutional Repository) ● Metadata: 114478 (Link to Publication Site) ● Publication site (DOI): 10.1080/14686996.2016.1257344 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28179956 ● Summary page in Scopus @ Elsevier: 2-s2.0-85019147115 (Tokushima University Institutional Repository: 114478, DOI: 10.1080/14686996.2016.1257344, PubMed: 28179956, Elsevier: Scopus)
13.	Hirokazu Nishida, Taira Kajisa, Yuuya Miyazawa, Yuki Tabuse, Takuya Yoda, Haruko Takeyama, Hideki Kambara and Toshiya Sakata : Self-oriented immobilization of DNA polymerase tagged by titanium-binding peptide motif., Langmuir, Vol.31, No.2, 732-740, 2015. (Summary) We developed a titanium-binding-peptide-1 (TBP-1)-tagged DNA polymerase, for self-oriented immobilization onto a titanium oxide (TiO2) substrate. The enzymatic function of a polymerase immobilized on a solid state device is strongly dependent on the orientation of the enzyme. The TBP-tagged DNA polymerase, which was derived from a hyperthermophilic archaeon, was designed to incorporate the RKLPDA peptide at the N-terminus, and synthesized by translation processes in Escherichia coli (E. coli). The specific binding of the TBP-tagged DNA polymerase onto a TiO2 substrate was clearly monitored by surface plasmon resonance spectroscopy (SPR) and by surface potential detection with an extended-gate field effect transistor (FET). In the SPR analyses, constant quantities of the DNA polymerase were stably immobilized on the titanium substrate under flow conditions, regardless of the concentration of the DNA polymerase, and could be completely removed by a 4 M MgCl2 wash after measurement. The FET signal showed the contribution of the molecular charge in the TBP motif to the binding with TiO2. In addition, the TBP-tagged DNA polymerase-tethered TiO2 gate electrode enabled the effective detection of the positive charges of hydrogen ions produced by the DNA extension reaction, according to the FET principle. Therefore, the self-oriented immobilization platform based on the motif-inserted enzyme is suitable for the quick and stable immobilization of functional enzymes on biosensing devices. (Keyword) DNA-Directed DNA Polymerase / Peptides / titanium (Link to Publication Site) ● Publication site (DOI): 10.1021/la503094k (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25517038 ● Summary page in Scopus @ Elsevier: 2-s2.0-84922426822 (DOI: 10.1021/la503094k, PubMed: 25517038, Elsevier: Scopus)
14.	Jeong-Jun Yoon, Kiyohiko Igarashi, Taira Kajisa and Masahiro Samejima : Purification, identification and molecular cloning of glycoside hydrolase family 15 glucoamylase from the brown-rot basidiomycete Fomitopsis palustris., FEMS Microbiology Letters, Vol.259, No.2, 288-294, 2006. (Summary) The brown-rot basidiomycete Fomitopsis palustris produces a major extracellular enzyme of 72 kDa when the fungus is incubated in cellulose culture with 0.2% cellobiose. This protein was purified by column chromatography, and the amino acid sequences of its proteolytic fragments were analyzed. The N-terminal amino acid sequence of one of the fragments showed high identity with fungal glycoside hydrolase family 15 glucoamylases. As its kinetic efficiency increased in proportion to the degree of polymerization of the substrate, the protein was identified as a glucoamylase. A cDNA encoding the glucoamylase (gla) was cloned by reverse transcriptase PCR. (Keyword) Amino Acid Sequence / Amino Acids / Base Sequence / Cloning, Molecular / DNA, Complementary / DNA, Fungal / Genes, Fungal / Glucan 1,4-alpha-Glucosidase / Kinetics / Molecular Sequence Data / Polyporales (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1574-6968.2006.00279.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16734792 ● Summary page in Scopus @ Elsevier: 2-s2.0-33744817362 (DOI: 10.1111/j.1574-6968.2006.00279.x, PubMed: 16734792, Elsevier: Scopus)
15.	Taira Kajisa, Makoto Yoshida, Kiyohiko Igarashi, Akira Katayama, Takeshi Nishino and Masahiro Samejima : Characterization and molecular cloning of cellobiose dehydrogenase from the brown-rot fungus Coniophora puteana., Journal of Bioscience and Bioengineering, Vol.98, No.1, 57-63, 2004. (Summary) Cellobiose dehydrogenase (CDH) was purified from the brown-rot fungus Coniophora puteana grown in culture containing crystalline cellulose as a carbon source. The purified enzyme gave a single band at 115 kDa on SDS-PAGE and showed a typical flavocytochrome absorption spectrum. The enzyme oxidized both cellobiose and cellooligosaccharides, but not their monomer, glucose, suggesting typical kinetic features of CDH. A cDNA encoding CDH was cloned by RT-PCR using primers designed from the consensus sequences of known CDHs from white-rot fungi. The cDNA consists of 2448 bp, including an open reading frame encoding the 18 amino acids of the putative signal peptide and the 756 amino acids of the mature protein. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) data for tryptic fragments of the purified C. puteana CDH were consistent with partial amino acid sequences of the mature protein deduced from the cloned cDNA. Moreover, the sequences contained common characteristics of CDH, i.e., two possible residues for a heme ligand (Met 64 and His 160), a flavin-binding motif, and two glucose-methanol-choline oxidoreductase motifs. This is the first cloning of CDH from a brown-rot fungus, and the results suggest structural and kinetic similarity of C. puteana CDH to white-rot fungal CDHs. (Link to Publication Site) ● Publication site (DOI): 10.1016/S1389-1723(04)70242-X (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16233666 ● Summary page in Scopus @ Elsevier: 2-s2.0-4143137705 (DOI: 10.1016/S1389-1723(04)70242-X, PubMed: 16233666, Elsevier: Scopus)

Review, Commentary:

1.	Hiroki Takanari and Taira Kajisa : 医光融合研究の最先端, OPTRONICS, Vol.39, No.465, 111-116, Sep. 2020. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520854805366131456 (CiNii: 1520854805366131456)

Proceeding of International Conference:

1.	Shogo Miyamura, Ryo Oe, Takuya Nakahara, S. Taue, Yu Tokizane, Takeo Minamikawa, Taira Kajisa and Takeshi Yasui : Photonic RF Biosensing of SARS-CoV-2 nucleocapsid protein using dual fiber combs, 28th International Conference on Optical Fiber Sensors (OFS-28), Tu3.69, Nov. 2023. (Link to Publication Site) ● Publication site (DOI): 10.1364/OFS.2023.Tu3.69 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85192152683 (DOI: 10.1364/OFS.2023.Tu3.69, Elsevier: Scopus)
2.	Kohta Seki, Hidenori Koresawa, Eiji Hase, Yu Tokizane, Takeo Minamikawa, Taka-aki Yano, Taira Kajisa and Takeshi Yasui : Beam-angle-scanning surface plasmon resonance sensor, Optica Imaging and Applied Optics Congress 2022, JTu2A.6, Vancouver, Jul. 2022. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85139153703 (Elsevier: Scopus)
3.	MIYAMURA Shogo, Ryo Oe, Taira Kajisa, 田上周路, Takeo Minamikawa, Yoshiaki Nakajima, Kaoru Minoshima and Takeshi Yasui : Reduction of temperature frift in tefractive-index-sensing optical frequency comb by mechanical-sharing dual-fiber-cavity configuration, Conference on Lasers and Electro-Optics 2022 (CLEO2022), JTh3A.26, San Jose, May 2022.
4.	MIYAMURA Shogo, Ryo Oe, Takuya Nakahara, Shota Okada, Taira Kajisa, Shuji Taue, Yu Tokizane, Takeo Minamikawa, Taka-aki Yano, Kunihiro Otsuka, Ayuko Sakane, Takuya Sasaki, Koji Yasutomo and Takeshi Yasui : Dual-Comb Biosensing for Rapid Detection of SARS-CoV-2, Conference on Lasers and Electro-Optics 2022 (CLEO2022), JTh6A.6, San Jose, May 2022. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85139913953 (Elsevier: Scopus)
5.	Takuya Nakahara, Ryo Oe, Taira Kajisa, Shuji Taue, Takeo Minamikawa and Takeshi Yasui : Application of refractive-index-sensing optical frequency comb for biosensing of antigen-antibody reaction, Conference on Lasers and Electro-Optics (CLEO) 2021, Technical Digest (online), STu2A, Online, May 2021. (Link to Publication Site) ● Publication site (DOI): 10.1364/CLEO_SI.2021.STu2A.2 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85120454099 (DOI: 10.1364/CLEO_SI.2021.STu2A.2, Elsevier: Scopus)
6.	Takuya Nakahara, Oe Ryo, Takeo Minamikawa, Taue Shuji, Taira Kajisa and Takeshi Yasui : Fiber biosensor based on a combination of refractive-index-sensing optical comb with chemical surface modification, BiOS2021 in Photonics West 2021, 11635-11618, Online, Mar. 2021. (Link to Publication Site) ● Publication site (DOI): 10.1117/12.2583197 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1117/12.2583197 (DOI: 10.1117/12.2583197)
7.	Takuya Nakahara, Ryo Oe, Takeo Minamikawa, Shuji Taue, Taira Kajisa and Takeshi Yasui : Intra-cavity biosensing in refractive- index-sensing optical comb, 14th Pacific Rim Conference on Lasers and Electro-Optics (CLEO PR 2020), Online, Aug. 2020.
8.	Takuya Nakahara, Ryo Oe, Taira Kajisa, Shuji Taue, Takeo Minamikawa and Takeshi Yasui : Refractive-index-sensing optical comb using intra-cavity multi-mode-interference fiber sensor and its application for bio-sensing, OSA Optical Sensors and Sensing, JTu2A.23, Online, Jun. 2020. (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-85118610135 (Elsevier: Scopus)

Proceeding of Domestic Conference:

1.	Arisa Onohara, Yu Tokizane, Eiji Hase, Takeo Minamikawa, Taira Kajisa and Takeshi Yasui : 2次アプタマーを用いた表面プラズモン共鳴センサーに関する検討, 2024年度応用物理・物理系学会中国四国支部合同学術講演会, Dp-6, Jul. 2024.
2.	Kohta Seki, Hidenori Koresawa, Eiji Hase, Yu Tokizane, Taira Kajisa, Takeo Minamikawa and Takeshi Yasui : 近赤外光を用いた高速入射角走査型表面プラズモン共鳴センサーの開発, 第69回応用物理学会春季学術講演会, 26p-E302-9, Mar. 2022.
3.	Shota Hosoyamada, Shin-ichi Tsukumo, Taira Kajisa, Koji Yasutomo and Takeshi Yasui : プラズモニクスバイオセンサを用いたエクソソーム中のマイクロRNA断片の超高感度検出, 第69回応用物理学会春季学術講演会, 24p-E104-2, Mar. 2022.
4.	Kohta Seki, Hidenori Koresawa, Eiji Hase, Taira Kajisa, Takeo Minamikawa and Takeshi Yasui : 高速入射角走査型表面プラズモン共鳴センサーのバイオセンシング応用, レーザー学会学術講演会第42回年次大会, I03-13a-IX-02, Jan. 2022.
5.	MIYAMURA Shogo, Ryo Oe, Taira Kajisa, Yu Tokizane, Takeo Minamikawa, 田上周路 and Takeshi Yasui : デュアル屈折率センシング光コムを用いた温度補償型屈折率センシング, レーザー学会学術講演会第42回年次大会, E02-12p-V-04, Jan. 2022.
6.	Kohta Seki, Hidenori Koresawa, Eiji Hase, Taira Kajisa, Takeo Minamikawa and Takeshi Yasui : ガルバノ走査を用いた表面プラズモン共鳴バイオセンサーの高速化, Optics & Photonics Japan 2021, 28pD5, Oct. 2021.
7.	Taka-aki Yano, Taira Kajisa, Masayuki Shono, Yoshiya Miyasaka, Yuichi Hasegawa, Atsushi Saito, Makoto Itonaga and Takeshi Yasui : Highly-sensitive plasmonic detection of SARS-Cov-2 nucleocapsid protein using gold nanoparticle-enhanced SPR, 第82回応用物理学会秋季学術講演会, 10p-N404-13, Sep. 2021.
8.	Takuya Nakahara, Takeo Minamikawa, 田上周路, Taira Kajisa and Takeshi Yasui : 屈折率センシング光コムを用いたバイオセンシングに関する検討(3)~アビジン/ビオチン抗体抗原反応の検出~, 第68回応用物理学会春季学術講演会予稿集, 17a-Z08-10, Mar. 2021.
9.	Shota Hosoyamada, Hidenori Koresawa, Taira Kajisa and Takeshi Yasui : 近赤外光源を用いた高感度SPRバイオセンサの構築, 第68回応用物理学会春季学術講演会予稿集, 16p-Z22-12, Mar. 2021.
10.	Takuya Nakahara, Ryo Oe, Takeo Minamikawa, 田上周路, Taira Kajisa and Takeshi Yasui : 屈折率センシング光コムの共振器ファイバー表面修飾を用いたバイオセンシング, Optics & Photonics Japan 2020, 17aD11, Nov. 2020.
11.	Yuki Naya, Hiroki Takanari and Taira Kajisa : 毛細血管の可視化を目指したNarrow Band Imaging(NBI)の光源特性の検証, 第81回日本応用物理学会秋季学術講演会, Sep. 2020.
12.	Takuya Nakahara, Ryo Oe, Takeo Minamikawa, 田上周路, Taira Kajisa and Takeshi Yasui : 屈折率センシング光コムを用いたバイオセンシングに関する検討(2) ~共振器内バイオセンサーによる繰り返し周波数シフト特性~, 第67回応用物理学会春季学術講演会予稿集, 14p-B409-10, Mar. 2020.
13.	Takuya Nakahara, Ryo Oe, Takeo Minamikawa, 田上周路, Mikito Yasuzawa, Taira Kajisa, Kenzo Yamaguchi and Takeshi Yasui : バイオセンシング光コムのためのバイオセンサーの開発, LED総合フォーラム2020 in 徳島, P-12, Feb. 2020.
14.	takuya nakahara, ryo oe, Takeo Minamikawa, 田上周路, Mikito Yasuzawa, Taira Kajisa, Kenzo Yamaguchi and Takeshi Yasui : バイオセンシング光コムのためのファイバーバイオセンサーの作製, Optics & Photonics Japan 2019, 5aB4, Dec. 2019.
15.	Takuya Nakahara, Ryo Oe, Takeo Minamikawa, Mikito Yasuzawa, Taira Kajisa and Takeshi Yasui : 屈折率センシング光コムを用いたバイオセンシングに関する検討, 第80回応用物理学会秋季学術講演会, 20p-E205-6, Sep. 2019.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Ultra-sensitive and rapid detection of emerging and resurging viruses based on biomedical photonics of optical frequency comb (Project/Area Number: 22H00303 )
糖鎖および糖誘導体を認識する高感度細胞検出センサの開発 (Project/Area Number: 26790024 )
Search by Researcher Number (00643123)