Tokushima University / Educator and Researcher Directory --- Hirao, Akihiro

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Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 医学域 ⟩ Endwed Collaborative Research ⟩ Contribution ⟩ 地域消化器・総合内科学 ⟩

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Research

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Academic Paper (Judged Full Paper):

1.	Ryo Shinomiya, Yasushi Sato, Takanori Yoshimoto, Tomoyuki Kawaguchi, Akihiro Hirao, Koichi Okamoto, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto and Tetsuji Takayama : A case of treatmentresistant advanced gastric cancer with FGFR2gene alteration successfully treated with pemigatinib., International Cancer Conference Journal, Vol.13, 240-244, 2024. (Link to Publication Site) ● Publication site (DOI): 10.1007/s13691-024-00669-3 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1007/s13691-024-00669-3 (DOI: 10.1007/s13691-024-00669-3)
2.	Tetsu Tomonari, Yasushi Sato, Hironori Tanaka, Takeshi Mitsuhashi, Akihiro Hirao, Takahiro Tanaka, Tatsuya Taniguchi, Koichi Okamoto, Masahiro Sogabe, Hiroshi Miyamoto, Naoki Muguruma and Tetsuji Takayama : Therapeutic efficacy of lenvatinib in nonviral unresectable hepatocellular carcinoma., JGH Open, Vol.5, No.11, 1275-1283, 2021. (Tokushima University Institutional Repository) ● Metadata: 116741 (Link to Publication Site) ● Publication site (DOI): 10.1002/jgh3.12663 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1002/jgh3.12663 (Tokushima University Institutional Repository: 116741, DOI: 10.1002/jgh3.12663)
3.	Akihiro Hirao, Yasushi Sato, Hironori Tanaka, Kensei Nishida, Tetsu Tomonari, Misato Hirata, Masahiro Bando, Yoshifumi Kida, Takahiro Tanaka, Tomoyuki Kawaguchi, Hironori Wada, Tatsuya Taniguchi, Koichi Okamoto, Hiroshi Miyamoto, Naoki Muguruma, Toshihito Tanahashi and Tetsuji Takayama : MiR-125b-5p is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma., Cancers, Vol.13, No.19, 4917, 2021. (Summary) The mechanism of resistance to sorafenib in hepatocellular carcinoma (HCC) remains unclear. We analyzed miRNA expression profiles in sorafenib-resistant HCC cell lines (PLC/PRF5-R1/R2) and parental cell lines (PLC/PRF5) to identify the miRNAs responsible for resistance. Drug sensitivity, migration/invasion capabilities, and epithelial-mesenchymal transition (EMT) properties were analyzed by biochemical methods. The clinical relevance of the target genes to survival in HCC patients were assessed using a public database. Four miRNAs were significantly upregulated in PLC/PRF5-R1/-R2 compared with PLC/PRF5. Among them, miR-125b-5p mimic-transfected PLC/PRF5 cells (PLC/PRF5-miR125b) and showed a significantly higher IC50 for sorafenib compared with controls, while the other miRNA mimics did not. PLC/PRF5-miR125b showed lower E-cadherin and higher Snail and vimentin expression-findings similar to those for PLC/PRF5-R2-which suggests the induction of EMT in those cells. PLC/PRF5-miR125b exhibited significantly higher migration and invasion capabilities and induced sorafenib resistance in an in vivo mouse model. Bioinformatic analysis revealed ataxin-1 as a target gene of miR-125b-5p. PLC/PRF5 cells transfected with ataxin-1 siRNA showed a significantly higher IC50, higher migration/invasion capability, higher cancer stem cell population, and an EMT phenotype. Median overall survival in the low-ataxin-1 patient group was significantly shorter than in the high-ataxin-1 group. In conclusion, miR-125b-5p suppressed ataxin-1 and consequently induced Snail-mediated EMT and stemness, leading to a poor prognosis in HCC patients. (Tokushima University Institutional Repository) ● Metadata: 116647 (Link to Publication Site) ● Publication site (DOI): 10.3390/cancers13194917 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34638401 ● Search Scopus @ Elsevier (PMID): 34638401 ● Search Scopus @ Elsevier (DOI): 10.3390/cancers13194917 (Tokushima University Institutional Repository: 116647, DOI: 10.3390/cancers13194917, PubMed: 34638401)
4.	Yasuteru Fujino, Kumiko Tanaka, Fumika Nakamura, Yoshifumi Kida, Akihiro Hirao, Yasuyuki Okada, Masanori Takehara, Akira Fukuya, Yoshimi Bando and Tetsuji Takayama : A CASE OF MULTIPLE COLONIC ULCERS CAUSED BY RHEUMATOID VASCULITIS, Gastroenterological Endoscopy, Vol.63, No.7, 1358-1364, 2021. (Keyword) リウマトイド血管炎 / 大腸潰瘍 (Link to Publication Site) ● Publication site (DOI): 10.11280/gee.63.1358 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390007282525435264 ● Search Scopus @ Elsevier (DOI): 10.11280/gee.63.1358 (DOI: 10.11280/gee.63.1358, CiNii: 1390007282525435264)

Academic Paper (Unrefereed Paper):

1.	Akihiro Hirao, 宮井優, 近藤絵里, 金崎淑子, 新谷保実, 宮恵子, 武市充生, Hidetaka Iwasaki, Hironori Akizuki, 木内慎一郎, 上間健造, Michiko Yamashita, 藤井義幸 and 藤野修 : A Case of IgG4-related Disease that Developed 10Years after Onset of Type2 Diabetes Mellitus, 徳島赤十字病院医学雑誌 = Tokushima Red Cross Hospital Medical Journal, Vol.16, No.1, 82-87, 2011. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762951888256 (CiNii: 1050845762951888256)

Proceeding of Domestic Conference:

1.	Akihiro Hirao, Yasushi Sato, Hironori Tanaka, Takahiro Tanaka, Tetsu Tomonari, Tatsuya Taniguchi, Koichi Okamoto, Naoki Muguruma, Kensei Nishida and Tetsuji Takayama : 肝細胞癌においてmiR-125b-5pは上皮間葉転換を引き起こし，ソラフェニブに対して耐性を獲得する, 第19回日本臨床腫瘍学会学術集会, Feb. 2022.
2.	Akihiro Hirao, Yasushi Sato and Tetsuji Takayama : 肝細胞癌におけるソラフェニブ耐性化バイオマーカーとしてのmiR125b-5p-ATXN1 axisの有用性., JDDW2021(第29回日本消化器医関連学会週間), Nov. 2021.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Search by Researcher Number (90780031)