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Tokushima UniversityGraduate School of Biomedical Sciences医学域Endwed Collaborative ResearchContributionDepartment of Community Medicine and Medical Science
Tokushima UniversityResearch ClustersResearch Clusters (Registered)2203017 消化器がんと脂肪細胞のクロストーク機構解明による早期診断と標的治療法の開発
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Academic Paper (Judged Full Paper):

1. Ryo Shinomiya, Yasushi Sato, Takanori Yoshimoto, Tomoyuki Kawaguchi, Akihiro Hirao, Koichi Okamoto, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto and Tetsuji Takayama :
A case of treatmentresistant advanced gastric cancer with FGFR2gene alteration successfully treated with pemigatinib.,
International Cancer Conference Journal, Vol.in press, 2024.
(DOI: 10.1007/s13691-024-00669-3)
2. Masahiro Sogabe, Toshiya Okahisa, Miwako Kagawa, Motoko Sei, Hiroyuki Ueda, reiko yokoyama, Kaizo Kagemoto, Hironori Tanaka, Yoshifumi Kida, Fumika Nakamura, Tetsu Tomonari, Koichi Okamoto, Yutaka Kawano, Hiroshi Miyamoto, Yasushi Sato, Masahiko Nakasono and Tetsuji Takayama :
Association of metabolic dysfunction-associated steatotic liver disease with erosive esophagitis development: a longitudinal observational study.,
Journal of Gastroenterology and Hepatology, Vol.Online ahead of print., 2024.
(DOI: 10.1111/jgh.16530,   PubMed: 38419514)
3. Yutaka Kawano, Maki Tanaka, Yasushi Sato, Shigekazu Sugino, Jun Suzuki, Masaki Fujishima, Eri Okumura, Hideo Takekoshi, Osamu Uehara, Shintaro Sugita, Yoshihiro Abiko, Tetsu Tomonari, Hironori Tanaka, Hidekatsu Takeda and Tetsuji Takayama :
Acanthopanax senticosus ameliorates steatohepatitis through HNF4 alpha pathway activation in mice.,
Scientific Reports, Vol.14, No.1, 110, 2024.
(DOI: 10.1038/s41598-023-50625-z,   PubMed: 38167633)
4. Tetsu Tomonari, Joji Tani, Yasushi Sato, Hironori Tanaka, Takahiro Tanaka, Tatsuya Taniguchi, Yutaka Kawano, Asahiro Morishita, Koichi Okamoto, Masahiro Sogabe, Hiroshi Miyamoto, Tsutomu Masaki and Tetsuji Takayama :
Clinical Features and Outcomes of Conversion Therapy in Patients with Unresectable Hepatocellular Carcinoma.,
Cancers, Vol.15, No.21, 5221, 2023.
(DOI: 10.3390/cancers15215221)
5. Reiko Yokoyama, Yasushi Sato, Fumika Nakamura, Kaizo Kagemoto, Yasuhiro Mitsui, Koichi Okamoto, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto and Tetsuji Takayama :
Efficacy of immune checkpoint inhibitors in patients with anorectal melanoma in association with immune-related adverse events: a case series.,
Clinical Journal of Gastroenterology, Vol.Online ahead of print., 2023.
(DOI: 10.1007/s12328-023-01849-z,   PubMed: 37632658,   Elsevier: Scopus)
6. Yasushi Sato, Koichi Okamoto, Yutaka Kawano, Akinari kasai, Tomoyuki Kawaguchi, Tamotsu Sagawa, Masahiro Sogabe, Hiroshi Miyamoto and Tetsuji Takayama :
Novel Biomarkers of Gastric Cancer: Current Research and Future Perspectives.,
Journal of Clinical Medicine, Vol.12, 4646, 2023.
(DOI: 10.3390/jcm12144646,   Elsevier: Scopus)
7. Tamotsu Sagawa, Yasushi Sato, Hiroyuki Nagashimia, Kohichi Takada, Mamoru Takahashi, Masahiro Hiarakawa, Kyoko Hamaguchi, Fumito Tamura, Koshi Fujikawa, Koichi Okamoto, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto and Tetsuji Takayama :
Hilar/mediastinal and cutaneous drug-induced sarcoidosis-like reaction associated with immune checkpoint inhibitors in metastatic colorectal cancer: a case report.,
Frontiers in Immunology, Vol.14, 1203621, 2023.
(DOI: 10.3389/fonc.2023.1203296,   PubMed: 37492584,   Elsevier: Scopus)
8. Tamotsu Sagawa, Yasushi Sato, Masahiro Hirakawa, Kyoko Hamguchi, Fumito Tamura, Hiroyuki Nagashima, Koshi Fujikawa, Koichi Okamoto, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto and Tetsuji Takayama :
Case Report: Longitudinal monitoring of clonal evolution by circulating tumor DNA for resistance to anti-EGFR antibody in a case of metastatic colorectal cancer.,
Frontiers in Oncology, Vol.13, 1203296, 2023.
(DOI: 10.3389/fonc.2023.1203296,   PubMed: 37434969,   Elsevier: Scopus)
9. Osamu Uehara, Norihiro Nakamoto, Daichi Hiraki, Durga Paudel, Nodoka Sugiyama, Tetsuro Morikawa, Koki Yoshida, Yutaka Kawano, Tsuyoshi Shimo, Yasushi Furuichi, Hiroko Miura and Yoshihiro Abiko :
Effects of prolonged stimulation with heated tobacco products (Ploom TECH+) on gingival epithelial cells,
Journal of Periodontal Research, Vol.58, No.3, 553-563, 2023.
(Tokushima University Institutional Repository: 118466,   DOI: 10.1111/jre.13123,   PubMed: 36974375)
10. Tetsu Tomonari, Hironori Tanaka, Takahiro Tanaka, Tatsuya Taniguchi, Masahiro Sogabe, Yutaka Kawano, Koichi Okamoto, Hiroshi Miyamoto, Yasushi Sato and Tetsuji Takayama :
A case of complete response with rechallenge-lenvatinib plus transcatheter arterial chemoembolization for unresectable hepatocellular carcinoma refractory to multiple molecular-targeted agent treatments.,
Clinical Journal of Gastroenterology, Vol.16, No.3, 438-443, 2023.
(DOI: 10.1007/s12328-023-01777-y,   PubMed: 36856957)
11. Tetsu Tomonari, Joji Tani, Chikara Ogawa, Akihiro Deguchi, Tomonori Senoh, Akio Moriya, Hiroshi Shibata, Hiroshi Fukuno, Hironori Tanaka, Takahiro Tanaka, Tatsuya Taniguchi, Masahiro Sogabe, Yutaka Kawano, Akihiro Morishita, Koichi Takaguchi, Hiroshi Miyamoto, Yasushi Sato, Tsutomu Masaki and Tetsuji Takayama :
Multicenter retrospective study of Initial treatment outcome and feasibility of initiating dose reduction of cabozantinib in unresectable hepatocellular carcinoma.,
Hepatology Research, Vol.53, No.2, 172-178, 2023.
(DOI: 10.1111/hepr.13845,   PubMed: 36214071)
12. Yasushi Sato, Yasuyuki Okada, Yasuteru Fujino, Tomoyuki Kawaguchi, Yoshifumi Kida, Yasuhiro Mitsui, Hironori Tanaka, Tetsu Tomonari, Shinji Kitamura, Koichi Okamoto, Yutaka Kawano, Hiroshi Miyamoto, Masahiro Sogabe and Tetsuji Takayama :
Clinical Outcomes of Comprehensive Genomic Profiling Tests for Gastrointestinal Cancers: Experience from Tokushima University Hospital.,
The Journal of Medical Investigation : JMI, Vol.70, No.1.2, 154-159, 2023.
(Tokushima University Institutional Repository: 118346,   DOI: 10.2152/jmi.70.154,   PubMed: 37164713)
13. Yutaka Kawano, Jun-ichi Yoshida, Fumiya Harada, Osamu Uehara, Yoshihiro Abiko, Hiroki Nagayasu, Takeo Maida, Tomofumi Kawakami and Yuichiro Eguchi :
Elucidating the effect humanoid robot (Pepper) on promoting the hepatitis virus tests,
Acta Hepatologica Japonica, Vol.63, No.8, 388-391, 2022.
(DOI: 10.2957/kanzo.63.388,   CiNii: 1390293025962862080)
14. Yutaka Kawano :
Alterations in the oral microbiome of individuals with a healthy oral environment following COVID-19 vaccination,
BMC Oral Health, Vol.22, No.1, 2022.
(DOI: 10.1186/s12903-022-02093-6,   PubMed: 35241064,   Elsevier: Scopus)

Academic Paper (Unrefereed Paper):

1. Yutaka Kawano :
食べ過ぎだけではない肥満の理由,
Seibutsu-kogaku Kaishi, Vol.101, No.1, 33, 2023.
(DOI: 10.34565/seibutsukogaku.101.1_33,   CiNii: 1390013408148989824)

Review, Commentary:

1. Yasushi Sato, Koichi Okamoto, Yoshifumi Kida, Yasuhiro Mitsui, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto and Tetsuji Takayama :
Overview of Chemotherapy for Gastric Cancer.,
Journal of Clinical Medicine, Vol.12, No.4, 1336, Feb. 2023.
(Tokushima University Institutional Repository: 118894,   DOI: 10.3390/jcm12041336,   PubMed: 36835872)

Proceeding of International Conference:

1. Hironori Tanaka, Tetsu Tomonari, Ryo Shinomiya, Mai Yonezawa, Yutaka Kawano and Tetsuji Takayama :
Usefulness of shear wave elastography for evaluation of HCC recurrence after ablation.,
APASL2024, Kyoto, Mar. 2024.
2. Yutaka Kawano, Maki Tanaka, Yasushi Sato, Tetsu Tomonari, Hironori Tanaka, Takeshi Mitsuhashi and Tetsuji Takayama :
Activation of HNF4α pathway by treatment with botanical plant, Acanthopanax Senticosus, ameliorates steatohepatitis in high-fat fed mice model.,
AASLD2023, Boston, Nov. 2023.
3. Yasushi Sato, Kazuyoshi Noda, Yasuyuki Okada, Kensei Nishida, Yutaka Kawano, Toshihito Tanahashi, Masanori Takehara, Yasuteru Fujino, Koichi Okamoto, Hiroshi Miyamoto and Tetsuji Takayama :
Exosomal miR-199a-3p secreted from cancer-associated adipocytes promote pancreatic cancer progression.,
DDW2023, Chicago, May 2023.
4. Yutaka Kawano, Maki Tanaka, Yasushi Sato, Tetsu Tomonari, Hironori Tanaka, Takeshi Mitsuhashi and Tetsuji Takayama :
Activation of HNF4α pathway by treatment with botanical plant, Acanthopanax senticosus, ameliorates steatohepatitis in high-fat fed mice model.,
DDW2023, Chicago, May 2023.

Proceeding of Domestic Conference:

1. Yutaka Kawano, Tetsu Tomonari, Yasushi Sato and Tetsuji Takayama :
MAFLD/MASHマウスモデルを用いたフィトケミカル含有食品エゾウコギの基礎検討.,
第42回Cytoprotection研究会, Mar. 2024.
2. Akira Fukuya, Yasushi Sato, Yasuyuki Okada, Koichi Okamoto, Yutaka Kawano, Hiroshi Miyamoto, Tetsuji Takayama, Kaizo Kagemoto and Yoshifumi Kida :
UBR4 EGFR EGFR --.,
第21回日本臨床腫瘍学会学術集会, Feb. 2024.
3. shot fujimoto, Takanori Kashihara, takanori miyake, Koichi Okamoto, Yutaka Kawano, Hiroshi Miyamoto, Masahiro Sogabe, Yasushi Sato and Tetsuji Takayama :
抗c-KIT抗体フラグメントと近赤外蛍光内視鏡を用いた水分子イメージングおよび光治療によるGISTの新規診断治療法の開発.,
第20回日本消化管学会総会学術集会, Feb. 2024.
4. Tetsu Tomonari, 谷 丈二, Hironori Tanaka, Yutaka Kawano, 森下 朝洋, 正木 勉 and Tetsuji Takayama :
切除不能肝細胞癌に対するデュルバルマブ+トレメリムマブ併用療法の初期治療成績.,
第29回日本肝がん分子標的治療研究会, Jan. 2024.
5. Reiko Yokoyama, Yasushi Sato, Fumika Nakamura, Tomoyuki Kawaguchi, Kaizo Kagemoto, Yoshifumi Kida, Yasuhiro Mitsui, Yasuteru Fujino, Koichi Okamoto, Yutaka Kawano, Hiroshi Miyamoto and Tetsuji Takayama :
直腸悪性黒色腫に対する免疫チェックポイント阻害剤の効果予測因子としての irAE の意義.,
第 61 回日本癌治療学会学術集会, Oct. 2023.
6. Yutaka Kawano, 渡邉 奈々恵, 西山 正彦, 小野 薫, Yasushi Sato, 照井 健, 日下部 俊郎, Tetsu Tomonari, Hironori Tanaka and Tetsuji Takayama :
がん関連疲労に対するエゾウコギ含有食品の実行可能性試験.,
第 61 回日本癌治療学会学術集会, Oct. 2023.
7. Yutaka Kawano, 田中 真樹, 藤島 雅基, 奥村 衣梨, 竹腰 英夫, 武田 秀勝, Yasushi Sato and Tetsuji Takayama :
脂肪肝モデルマウスを用いた,エゾウコギによる治療応用に向けての基礎研究 第2報.,
クロレラ・機能性植物研究会 第5回研究集会, Oct. 2023.
8. Tetsu Tomonari, Hironori Tanaka, Yutaka Kawano, Yasushi Sato and Tetsuji Takayama :
デュルバルマブ+トレメリムマブ併用療法を見据えた肝細胞癌に対するアテゾリズマブ+ベバシズマブ併用療法の治療戦略.,
第28回日本肝がん分子標的治療研究会, Jun. 2023.
9. Tetsu Tomonari, Hironori Tanaka, Tatsuya Taniguchi, Yutaka Kawano, Hiroshi Miyamoto and Tetsuji Takayama :
悪性肝腫瘍に対するEmprint Ablation Systemの治療成績.,
日本超音波医学会第96回学術集会, May 2023.
10. Tetsu Tomonari, Yasushi Sato, Hironori Tanaka, Tatsuya Taniguchi, Yutaka Kawano, Tsutomu Masaki and Tetsuji Takayama :
アテゾリズマブ+ベバシズマブ,レンバチニブを用いた切除不能肝細胞癌に対する根治的Conversion therapyの治療成績.,
第20回日本臨床腫瘍学会学術集会, Mar. 2023.
11. Tetsu Tomonari, Hironori Tanaka, Tatsuya Taniguchi, Yutaka Kawano and Tetsuji Takayama :
切除不能進行肝細胞癌に対するアテゾリズマブ+ベバシズマブ併用療法後のレンバチニブ及び根底的Conversion治療の有効性.,
第27回日本肝がん分子標的治療研究会, Jan. 2023.
12. Yutaka Kawano :
非アルコール性脂肪肝疾患(NAFLD)に対する エソウコギエキスの基礎的検討,
Acta Hepatologica Japonica, Vol.63, A312, Apr. 2022.

Et cetera, Workshop:

1. Yutaka Kawano, 渡邉 奈々恵, 田中 真樹, 藤島 雅基, 奥村 衣梨, 竹腰 英夫 and 武田 秀勝 :
がん関連疲労(倦怠感)に対する エゾウコギ摂取の実⾏可能性評価試験,
第4回クロレラ・機能性植物研究集会, Sep. 2022.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • フィトケミカル含有食品エゾウコギによる、新しいNAFLD/NASH治療法の開発 (Project/Area Number: 22K07478 )
  • Analysis of 5-FU resistance in colon cancer using BH3 profiling (Project/Area Number: 17K07200 )
  • Oxidative stress in hepatocarcinogenesis from NASH (Project/Area Number: 15K09013 )
  • Prediction of drug sensitivity to gastric cancer using BH3 profiling (Project/Area Number: 26460943 )
  • Novel strategy against GVHD using NB-UVB with expansion of Treg cells (Project/Area Number: 25461429 )
  • BH3 profiling for regulatory T cells in patients with chronic graft-versus-host disease (cGVHD) (Project/Area Number: 24890180 )
  • 非アルコール性脂肪性肝炎発症における鉄代謝関連因子の分子機構解明と治療法への応用 (Project/Area Number: 21790676 )
  • Analysis of peripheral blood hematopoietic stemness using human hTERT-stromal cells (Project/Area Number: 19790672 )
  • TERT導入ストローマ・クローン細胞による効率的な造血幹細胞の体外増幅法の開発 (Project/Area Number: 17790457 )
  • Ex vivo expansion of human cord blood Lin-CD34-cells using indian hedgehog stromal cells (Project/Area Number: 17591003 )
  • Search by Researcher Number (80398320)