Tokushima University / Educator and Researcher Directory --- Matsuda, Taku

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Tokushima University ⟩ Graduate School of Biomedical Sciences ⟩ 医学域 ⟩ 特定研究部門 ⟩ 教育支援系 ⟩ Department of Medical Education Support ⟩

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Research

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Academic Paper (Judged Full Paper):

1.	Hiroshi Kagusa, Yamaguchi Izumi, Shono Kenji, Mizobuchi Yoshifumi, Shikata Eiji, Taku Matsuda, Takeshi Miyamoto, Keijiro Hara, Kitazato T Keiko, Yoshihiro Uto, Kanematsu Yasuhisa and Yasushi Takagi : Differences in amyloid-β and tau/p-tau deposition in blood-injected mouse brains using micro-syringe to mimic traumatic brain microhemorrhages, Journal of Chemical Neuroanatomy, Vol.130, 102258, 2023. (Summary) Cerebral microbleeds (CMBs) due to traumatic brain injuries (TBI) have been shown to lead to cognitive decline and impairment. CMBs caused by TBI may be associated with pathophysiological mechanisms involving inflammation and the accumulation of amyloid-β (Aβ), tau, and phosphorylated tau (p-tau), contributing to cognitive abnormalities. However, their relationships remain unclear. To test our hypothesis that Aβ, tau, and p-tau are accumulated and regulated separately in mice with injuries imitating CMBs from TBI, we studied. Seven-week-old C57BL/6 male mice were injected with 15 μL of heparinized autologous blood or saline by micro-syringe into the front lobe. Expression profiles and regulation of Aβ, tau, and p-tau were assessed immunohistochemically over time. On day 7 after blood injection, Iba-1 and S100B cells in damaged cortex adjacent to the injection site were higher than saline injection group and non-injected sham. On days 3-14, Aβ deposition were gradually increased but normalized by day 28. In contrast, tau/p-tau deposition gradually increased during days 14-28 and dispersed along the corticomedullary junction adjacent to hem deposits, indicating different expression profiles from Aβ. Deposits of Aβ, but not tau/p-tau, were phagocytosed by CD163 macrophages increased by Gc-protein macrophage-activating factor during days 7-28, suggesting different mechanisms of deposition and regulation between Aβ and tau/p-tau. Deposition and regulation differ between Aβ and tau/p-tau in mice with injuries mimicking CMBs from TBI. Further clarification of relationships between the pathologies of cognitive impairment and their neurodegenerative consequences is needed. (Keyword) Amyloid-β / Cognitive impairment / Tauopathy / Traumatic cerebral microbleed (Tokushima University Institutional Repository) ● Metadata: 119582 (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jchemneu.2023.102258 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36925083 ● Search Scopus @ Elsevier (PMID): 36925083 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jchemneu.2023.102258 (Tokushima University Institutional Repository: 119582, DOI: 10.1016/j.jchemneu.2023.102258, PubMed: 36925083)

Proceeding of International Conference:

1.	Taku Matsuda, Ryoma Morigaki, Hiroaki Hayasawa, Hiroshi Koyama, Teruo Oda, Kazuhisa Miyake and Yasushi Takagi : Striatal parvalbumin interneurons, not cholinergic interneurons, are activated in a mouse model of cerebellar dystonia, NEURO2024, Fukuoka, Jul. 2024.

Proceeding of Domestic Conference:

1.	Taku Matsuda, Keijiro Hara, 鈴木海斗, Kazuhisa Miyake and Yasushi Takagi : A case of cerebrospinal fluid leaks diagnosed by examination of posttraumatic higher brain dysfunction, 日本脳神経外科学会第83回学術総会, Oct. 2024.
2.	Taku Matsuda, Keijiro Hara, Kaito Suzuki, Kazuhisa Miyake and Yasushi Takagi : 外傷後の高次脳機能障害の精査で脳脊髄液漏出症と診断された一例, 23回舞連カンファレンス, Aug. 2024.
3.	Ryoma Morigaki, Kazuhisa Miyake, Taku Matsuda and Yasushi Takagi : 赤核振戦に伴う痛みに対して著効した脳深部刺激療法の一例, 第6回中国四国機能神経外科懇話会, Mar. 2024.
4.	Ryoma Morigaki, Kazuhisa Miyake, Ryosuke Miyamoto, 大前博司, Taku Matsuda, Hiroshi Koyama, Yuishin Izumi and Yasushi Takagi : GPi-DBSが著効した外転型痙攣性発声障害の一例, 第63回日本定位機能外科学会, Feb. 2024.
5.	Taku Matsuda, Hiroshi Kagusa, Nori Sato, 梅山公子, Tetsuya Matsuura, Yasuhisa Kanematsu and Yasushi Takagi : HALによる歩行訓練で歩容の改善を得られた深部感覚障害による歩行障害の一例, Dec. 2023.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Search by Researcher Number (50842845)