Tokushima University / Educator and Researcher Directory --- Mitsuhashi, Takeshi

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Tokushima University ⟩ University Hospital ⟩ Central Clinical Facilities ⟩ Cancer Management Center ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Internal Medicine ⟩ Gastroenterology ⟩

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Research

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Academic Paper (Judged Full Paper):

1.	Yasuhiro Mitsui, Yasushi Sato, Ryo Shinomiya, Satoshi Sumida, Shota Fujimoto, Akiko Okada, Takeshi Mitsuhashi, Tomoyuki Kawaguchi, Kaizo Kagemoto, Yoshifumi Kida, Koichi Okamoto, Hisanori Uehara and Tetsuji Takayama : Case Report: Zolbetuximab-induced gastritis with protein-losing gastroenteropathy and hypogammaglobulinemia: a case implicating IgA vasculitis, Frontiers in Oncology, 15, 1644263, 2025. (Keyword) Claudin-18.2 / gastric cancer / gastritis / hypoalbuminemia / hypogammaglobulinemia / IgA vasculitis / protein-losing gastroenteropathy / zolbetuximab (Link to Publication Site) ● Publication site (DOI): 10.3389/fonc.2025.1644263 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-105012982726 (DOI: 10.3389/fonc.2025.1644263, Elsevier: Scopus)
2.	Kaizo Kagemoto, Koichi Okamoto, Yasuyuki Okada, Motoko Sei, Shota Fujimoto, Mai Yagi, Takeshi Mitsuhashi, Hiroyuki Ueda, Takanori Yoshimoto, Takanori Kashihara, Tomoyuki Kawaguchi, Yoshifumi Kida, Yasuhiro Mitsui, Yutaka Kawano, Masahiro Sogabe, Hiroshi Miyamoto, Yasushi Sato, Naoki Muguruma and Tetsuji Takayama : Clinicopathological evaluation of the efficacy of endoscopic treatment for sessile serrated lesions comparing endoscopic mucosal resection, cold snare polypectomy, and underwater endoscopic mucosal resection., DEN Open, 5, 1, e70051, 2025. (Summary) Recently, various endoscopic treatments for colorectal polyps have been reported, including cold snare polypectomy (CSP) and underwater endoscopic mucosal resection (UEMR), in addition to EMR. However, a precise treatment strategy for sessile serrated lesions (SSL) has not been established. In this study, we analyzed the clinicopathological features of SSL resected by EMR, CSP, and UEMR to determine the most suitable treatment for SSL. A total of 92 SSL resected via EMR ( = 11), CSP ( = 36), and UEMR ( = 45) were retrospectively enrolled between February 2021 and October 2022. To evaluate pathological findings, we examined SSL samples, which were stretched before formalin fixation and sectioned at 2-mm intervals. Primary outcomes were the R0 resection rate and thickness of submucosal (SM) tissue specimens for each treatment. In addition, we evaluated SSL with dysplasia (SSLD) and the inverted growth pattern which may affect the vertical margin. The R0 resection rate significantly differed among the three groups (EMR, 73%; CSP, 42%; UEMR, 87%, = 0.001). The median thickness of SM tissue resected by CSP (0 µm) was significantly less than that by EMR (362 µm) and UEMR (325 µm; < 0.001). All four SSLDs were diagnosed endoscopically. Five SSLs with inverted growth patterns were pathologically diagnosed. Of these, two SSLs with inverted growth patterns could not be diagnosed endoscopically. UEMR is considered to be a suitable treatment option for SSL. CSP results were pathologically insufficient. Therefore, surveillance to evaluate local recurrence is important, and the results of further multicenter prospective studies should be referred. (Link to Publication Site) ● Publication site (DOI): 10.1002/deo2.70051 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39758158 ● Search Scopus @ Elsevier (PMID): 39758158 ● Search Scopus @ Elsevier (DOI): 10.1002/deo2.70051 (DOI: 10.1002/deo2.70051, PubMed: 39758158)

Proceeding of Domestic Conference:

1.	中嶋健吾, Toshiya Okahisa, Ryo Shinomiya, Tatsunao Sueuchi, Miwako Kagawa, Takeshi Mitsuhashi, Hiroyuki Ueda, Masahiro Sogabe, 宮本弘志, 佐藤康史, Masaki Oono and Tetsuji Takayama : 腸音解析による腸運動の評価．, 第123回日本消化器病学会四国支部例会, 高知., Jun. 2025.
2.	Toshiya Okahisa, Tatsunao Sueuchi, Miwako Kagawa, Takeshi Mitsuhashi, Tomoyuki Kawaguchi, Yoshifumi Kida, Yasuhiro Mitsui, Koichi Okamoto, Masahiro Sogabe and Tetsuji Takayama : <シンポジウム>睡眠中およびストレス負荷時の腸音解析による過敏性腸症候群の診断と病態評価., 第111回日本消化器病学会総会, Apr. 2025.
3.	Takeshi Mitsuhashi, Yutaka Kawano, Yasushi Sato, Masahiro Bando, Tetsu Tomonari and Tetsuji Takayama : CRISPR-Cas9スクリーニングライブラリーを用いた，肝がんに対するPARP阻害剤の耐性因子の探索的研究, 第43回サイトプロテクション研究会, Mar. 2025.
4.	岡部一郎, 中川忠彦, 緒方良輔, 小松崇俊, Takeshi Mitsuhashi, Masahiro Sogabe and Toshiya Okahisa : CARTの腹水処理時のサイトカインの動態．, 第43回日本アフェレシス学会関西地方会, 高松., Feb. 2025.
5.	川島武朗, 中川忠彦, 緒方良輔, 小松崇俊, Takeshi Mitsuhashi, Masahiro Sogabe and Toshiya Okahisa : CARTの腹水処理時の蛋白質回収率へ及ぼす濃縮圧の影響．, 第43回日本アフェレシス学会関西地方会, 高松., Feb. 2025.
6.	石川雅人, 石川寛, 飯尾未保, 佐藤純子, 石村美穂子, 続木美智, 鈴木泰子, 大森和世, 鈴木麻由, 石川美保, Miwako Kagawa, Tatsunao Sueuchi, 柴昌子, Masahiro Sogabe, Takeshi Mitsuhashi and Toshiya Okahisa : 健診受診者に対する大腸内視鏡検査施行前の食事制限の最適化., 日本総合健診医学会第53回大会,浦安., Jan. 2025.
7.	今村美和子, 崎川光子, 梶芳純子, 深川雅美, 大西裕美, 高橋幸子, 石川美保, 吉田拓馬, Miwako Kagawa, 柴昌子, Masahiro Sogabe, 岡久玲子, Masao Fuketa, Kenji Terada, Takeshi Mitsuhashi and Toshiya Okahisa : 健診受診者のメンタルヘルスケアへのストレングス・モデルの応用．, 日本総合健診医学会第53回大会,浦安., Jan. 2025.
8.	河野豊, 佐藤康史, Tetsu Tomonari, Hironori Tanaka, Masahiro Sogabe, 米澤真衣, Takeshi Mitsuhashi and Tetsuji Takayama : フィトケミカル含有食品エゾウコギによるNAFLD/NASH治療の基礎検討., 第110回日本消化器病学会総会, 徳島., May 2024.
9.	大塚真人, 佐藤康史, Ryo Shinomiya, Takeshi Mitsuhashi, 吉本貴則, 川口智之, 岡本耕一, Tetsu Tomonari, 河野豊, Masahiro Sogabe, 宮本弘志 and 高山哲治 : FGFR2遺伝子異常を認めた治療抵抗性進行胃癌に対してpemigatinibが著効した一例., 第120回日本消化器病学会四国支部例会, 高知., Dec. 2023.
10.	緒方良輔, Toshiya Okahisa, 竹内彩郁薫, 井形直紀, Akira Fukuya, Masahiro Sogabe, Naoya Tani, 山崎めぐみ, Takeshi Mitsuhashi, 笠井昭成, Hiroyuki Ueda, 三宅孝典, 佐藤康史, 友成哲 and Tetsuji Takayama : 模擬腹水評価系の構築による胸腹水濾過濃縮用装置の濾過器洗浄法の最適化．, 第116回日本消化器病学会四国支部例会,徳島., Nov. 2021.