Tokushima University / Educator and Researcher Directory --- Ishitani, Keisuke

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Tokushima University ⟩ University Hospital ⟩ 先端医科医療開発研究プロジェクト ⟩
Tokushima University ⟩ University Hospital ⟩ Clinical Division ⟩ Department of Ophthalmology, Otolaryngology, Dermatology, Orthopedics, and Plastic Surgery ⟩ Otolaryngology and Head and Neck Surgery ⟩
Tokushima University ⟩ Faculty of Medicine ⟩ School of Medicine ⟩ Course of Sensory Neuroscience ⟩ Otorhinolaryngology and Communicative Neuroscience ⟩

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Research

Field of Study

Subject of Study

Book / Paper

Academic Paper (Judged Full Paper):

1.	Seiichiro Kamimura, Keisuke Ishitani, Ryota Morozumi, Tatsuya Fujii and Yoshiaki Kitamura : High Remission Rate in Eosinophilic Chronic Rhinosinusitis Following More Than Two Years of Dupilumab Therapy, Laryngoscope Investigative Otolaryngology, 10, 6, e70311, 2025. (Keyword) biologics / dupilumab / endoscopic sinus surgery / eosinophilic chronic rhinosinusitis / remission (Link to Publication Site) ● Publication site (DOI): 10.1002/lio2.70311 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-105022292345 (DOI: 10.1002/lio2.70311, Elsevier: Scopus)
2.	Seiichiro Kamimura, Keisuke Ishitani, Ryota Morozumi and Yoshiaki Kitamura : TWO CASES OF MPO-ANCA-POSITIVE EGPA WITH CHRONIC RHINOSINUSITIS SHOWING DIFFERENT RESPONSES TO MEPOLIZUMAB, Japanese Journal of Allergology, 74, 5, 277-284, 2025. (Link to Publication Site) ● Publication site (DOI): 10.15036/arerugi.74.277 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390587295719454208 ● Search Scopus @ Elsevier (DOI): 10.15036/arerugi.74.277 (DOI: 10.15036/arerugi.74.277, CiNii: 1390587295719454208)
3.	Yoshiaki Kitamura, Seiichiro Kamimura, Tatsuya Fujii, Keisuke Ishitani, Naoki Kimoto, Hitoshi Shono, Ryo Kanamura, Eiji Kondou, Takahiro Azuma, Gou Satou and Hiroyuki Mizuguchi : Recent advances in the management of allergic rhinitis., The Journal of Medical Investigation : JMI, 72, 1.2, 14-20, 2025. (Summary) Allergic rhinitis (AR) is a type I allergic disease characterized by sneezing, watery rhinorrhea, and nasal obstruction. An epidemiological survey found that approximately 50% of Japanese individuals have AR.Histamine is a major chemical mediator that induces AR symptoms through its binding to histamine H1 receptor(H1R). We demonstrated that antihistamines have a blocking effect on histamine signaling of H1R, and the suppressive effect on histamine-induced up-regulation of transcriptional activation, and the suppressive effect on basal transcription of H1R in the absence of histamine which may be part of the inverse agonist action of antihistamine. Sublingual immunotherapy (SLIT) with a standardized Japanese cedar (JC) pollen significantly improved nasal symptoms and AR-related sleep disturbance in patients with JC pollinosis. Dual SLIT with JC pollen and house dust mites (HDM) suppressed both JC pollen-induced seasonal and HDM-induced perennial nasal symptoms in bisensitized patients with AR. Dual SLIT was more effective in suppressing nasal obstruction at the peak JC pollen period than mono SLIT with JC pollen. Posterior nasal neurectomy (PNN) improved nasal symptoms and medication scores in patients with severe perennial AR. Herein, we describe recent advances in the management of AR. J. Med. Invest. 72 : 14-20, February, 2025. (Keyword) Humans / Rhinitis, Allergic / Animals / Histamine Antagonists / Sublingual Immunotherapy (Tokushima University Institutional Repository) ● Metadata: 2013274 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.72.14 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 40268436 ● Search Scopus @ Elsevier (PMID): 40268436 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.72.14 (Tokushima University Institutional Repository: 2013274, DOI: 10.2152/jmi.72.14, PubMed: 40268436)
4.	Takao Yamashita, Takahiro Azuma, Seiichiro Kamimura, Keisuke Ishitani, Sho Takaoka, Gou Satou and Yoshiaki Kitamura : A Case of Nevoid Basal Cell Carcinoma Syndrome with an Odontogenic Keratocyst Removed by Endoscopic Endonasal Surgery, Practica Oto-Rhino-Laryngologica, 118, 2, 119-126, 2025. (Keyword) nevoid basal cell carcinoma syndrome / odontogenic keratocyst / endoscopic endonasal surgery (Link to Publication Site) ● Publication site (DOI): 10.5631/jibirin.118.119 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390866040574112384 ● Search Scopus @ Elsevier (DOI): 10.5631/jibirin.118.119 (DOI: 10.5631/jibirin.118.119, CiNii: 1390866040574112384)
5.	Seiichiro Kamimura, Keisuke Ishitani, Ryota Morozumi and Yoshiaki Kitamura : TWO CASES OF MPO-ANCA-POSITIVE EGPA WITH CHRONIC RHINOSINUSITIS SHOWING DIFFERENT RESPONSES TO MEPOLIZUMAB, Japanese Journal of Allergology, 74, 5, 277-284, 2025. (Summary) Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis associated with chronic rhinosinusitis (CRS) and bronchial asthma. Mepolizumab, an anti-IL-5 monoclonal antibody, has been used in the treatment of EGPA. We report two cases of MPO-ANCA-positive EGPA with CRS that exhibited differing responses to mepolizumab. In Case 1, nasal symptoms persisted despite mepolizumab treatment, and CRS recurred early after endoscopic sinus surgery (ESS). In contrast, Case 2 developed EGPA following dupilumab administration, but nasal symptoms improved with mepolizumab and remained well controlled. These cases suggest that the efficacy of mepolizumab for CRS in ANCA-positive EGPA varies among patients. Even in cases that respond well to treatment, recurrence may still occur, underscoring the importance of continuous follow-up in close collaboration with internal medicine specialists. (Keyword) anti-neutrophil cytoplasmic antibody / endoscopic sinus surgery / eosinophilic chronic rhinosinusitis / eosinophilic granulomatosis with polyangiitis / mepolizumab (Link to Publication Site) ● Publication site (DOI): 10.15036/arerugi.74.277 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 41083348 ● Summary page in Scopus @ Elsevier: 2-s2.0-105018648896 (DOI: 10.15036/arerugi.74.277, PubMed: 41083348, Elsevier: Scopus)

Proceeding of International Conference:

1.	Seiichiro Kamimura, Keisuke Ishitani, Ryota Morozumi, Tatsuya Fujii and Naoya Kitamura : Two cases of chronic rhinosinusitis associated with EGPA exhibiting different responses to mepolizumab, European rhinologic society 2025, Budapest, Hungary, Jun. 2025.

Proceeding of Domestic Conference:

1.	Yuka Aono, Seiichiro Kamimura, Yuki Ishitani, TOMURA Miki, Keisuke Ishitani, Sho Takaoka, Takahiro Azuma, Gou Satou and Yoshiaki Kitamura : 介在物を用いて超音波エコーガイド下に整復した鼻骨骨折の2例, 第35回日本頭頸部外科学会, Feb. 2026.
2.	Yuki Ishitani, TOMURA Miki, Keisuke Ishitani, Sho Takaoka, Seiichiro Kamimura, Takahiro Azuma, Gou Satou and Yoshiaki Kitamura : 頭頸部異所性胸腺腫例, 第35回日本頭頸部外科学会, Feb. 2026.
3.	川淵海翔, Katsuya Fujino, MOROZUMI Ryota, Keisuke Ishitani, Seiichiro Kamimura, Takahiro Azuma, Gou Satou and Yoshiaki Kitamura : 鼻出血を反復するオスラー病患者に対して硬化療法を施行した1例, 日耳鼻第50回中国四国地方部会, Jul. 2025.
4.	Yoshiaki Kitamura, Seiichiro Kamimura, Keisuke Ishitani and MOROZUMI Ryota : MPO-ANCA陽性のEGPAに伴う慢性鼻副鼻腔炎に対するメポリズマブ治療症例, 第87回耳鼻咽喉科臨床学会, Jun. 2025.
5.	MOROZUMI Ryota, Gou Satou, Takahiro Azuma, Eiji Kondou, Seiichiro Kamimura, Ryo Kanamura, Hitoshi Shono, Keisuke Ishitani, Sho Takaoka, TOMURA Miki, KAGEYAMA Asami, Katsuya Fujino and Yoshiaki Kitamura : 当院における外視鏡ORBEYEを用いた口蓋扁桃摘出術に関する検討, 第126回日本耳鼻咽喉科頭頸部外科学会, May 2025.
6.	MOROZUMI Ryota, Seiichiro Kamimura, Keisuke Ishitani and Yoshiaki Kitamura : Neisseria animalorisによる頸部リンパ節炎例, 第80回日耳鼻徳島県地方部会, Apr. 2025.
7.	Seiichiro Kamimura, Keisuke Ishitani, MOROZUMI Ryota, Tatsuya Fujii and Yoshiaki Kitamura : 好酸球性副鼻腔炎に対するデュピルマブの投与の継続2年以降の効果と薬物使用状況, 第80回日耳鼻徳島県地方部会, Apr. 2025.
8.	Seiichiro Kamimura, Keisuke Ishitani, MOROZUMI Ryota, Tatsuya Fujii and Yoshiaki Kitamura : 好酸球性副鼻腔炎に対するデュピルマブの投与継続2年以後の効果と薬物使用状況の検討, 第5回日本耳鼻咽喉科免疫アレルギー感染症学会, Apr. 2025.
9.	MOROZUMI Ryota, Seiichiro Kamimura, Keisuke Ishitani and Yoshiaki Kitamura : Neisseria animalorisによる頸部リンパ節炎例, 第5回日本耳鼻咽喉科免疫アレルギー感染症学会, Apr. 2025.
10.	Tatsuya Fujii, Keisuke Ishitani, Seiichiro Kamimura and Yoshiaki Kitamura : 当科で2019年にスギ花粉舌下免疫療法を開始した51症例の5年間の検討, 第5回日本耳鼻咽喉科免疫アレルギー感染症学会, Apr. 2025.
11.	Tatsuya Fujii, MOROZUMI Ryota, Keisuke Ishitani, Seiichiro Kamimura and Yoshiaki Kitamura : スギ花粉舌下免疫療法を3年継続した症例と脱落した症例の比較検討, 第7回日本アレルギー学会中国・四国地方会, Mar. 2025.
12.	Keisuke Ishitani, Seiichiro Kamimura, MOROZUMI Ryota, Tatsuya Fujii and Yoshiaki Kitamura : 当科における好酸球性鼻副鼻腔炎に対するメポリズマブ投与例の検討, 第7回日本アレルギー学会中国・四国地方会, Mar. 2025.
13.	Seiichiro Kamimura, Keisuke Ishitani, 野村和弘, 伊丹想, Tatsuya Fujii and Yoshiaki Kitamura : 好酸球性副鼻腔炎のサイトカイン発現に対する喘息合併とステロイド治療の影響, 第7回日本アレルギー学会中国・四国地方会, Mar. 2025.