Tokushima University / Educator and Researcher Directory --- Maezawa, Hiroshi

Personal Web Page

https://researchmap.jp/read0026281 (researchmap)

Field of Study

○	Radiation Biology, Radiation Oncology

Subject of Study

○	Studies of mechanism of radiobiological action on organisms using th techniques of soft x-ray microbeam and photon induced Auger effect., Study of biological effects of heavy ions on mammalian cells., Study of effects of cell growth factors and cytokines on mammalian cells exposed to radiation, heat and hyoxic condition., Study of protection of radiation injury on normal tissues. (microbeam, Auger effect, soft X-rays, heavy ions, radiation injury)

Book / Paper

Book:

1.	Hiroshi Maezawa : 放射線生物学改訂2版(放射線技術学シリーズ), オーム社, Nov. 2011. (Keyword) 放射線生物
2.	Yousuke Ejima, Hiroshi Kimura, Hiroshi Maezawa, Yuko Murakami and Yasunori Obata : 放射線生物学, Ohme Co. Ltd, Feb. 2010. (Keyword) Radiation Biology
3.	Yousuke Ejima, Hiroshi Kimura, Hiroshi Maezawa, Yuhko Murakami and Yasunori Obata : Radiation Biology, Ohmsha, Ltd., Tokyo, Jan. 2004. (Keyword) Radiation Biology
4.	電気学会放射波の医療応用と計測技術調査専門委員会編 and Hiroshi Maezawa : 先端放射医療技術と計測, CORONA PUBLISHING CO.,LTD, Tokyo, Nov. 2001.
5.	Kahoru Takakura, Hiroshi Maezawa, Katsumi Kobayashi and Kotaro Hieda : Synchrotron Radiation in the Biosciences, --- Strand breaks in DNA in buffered solution induced by monochromatic X-rays around the K-shell absorption edge of phosphorus. ---, Oxford University Press, Oxford, Aug. 1994.
6.	Shinji Matsumoto, Yoritika Matsudaira, Kunio Shinohara and Hiroshi Maezawa : フォトバイオロジー光プローブによる生物学の展開, Japan Scientific Societies Press, Tokyo, Oct. 1989. (Keyword) synchrotron radiation / bacteriophage T1

Academic Paper (Judged Full Paper):

1.	Yoshihiro Tanaka, Hitoshi Ikushima, Kazuya Kondo, Koichiro Kenzaki, Yoshimi Bando, Youichi Otomi and Hiroshi Maezawa : The value of diagnostic imaging in neoadjuvant chemoradiation therapy for non-small cell lung cancer, Japanese Journal of Clinical Radiology, Vol.58, No.1, 222-228, 2013. (Keyword) 非小細胞肺癌 / 術前導入化学放射線療法 / 癌画像診断 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1522825130745084544 ● Summary page in Scopus @ Elsevier: 2-s2.0-84873164822 (CiNii: 1522825130745084544, Elsevier: Scopus)
2.	Chiaki Abe, Yoshihiro Uto, Takashi Nakae, Yuuya Shinmoto, Keiichiro Sano, Hiroko Nakata, Mizue Teraoka, Yoshio Endo, Hiroshi Maezawa, Shin-ichiro Masunaga, Eiji Nakata and Hitoshi Hori : Evaluation of the In vivo Radiosensitizing Activity of EtanidazoleUsing Tumor-bearing Chick Embryo, Journal of Radiation Research, Vol.52, No.2, 208-214, 2011. (Summary) Chick embryos have been used as alternative experimental animals in various research fields, including virology, immunology, toxicology, oncology, and embryology. Until now, there have been no in vivo models using chick embryo to evaluate radiosensitizing activity. Here, the in vivo radiosensitizing activity of etanidazole, a well-known hypoxic cell radiosensitizer, was evaluated using tumor-bearing chick embryo. On the basis of tumor growth, drug administration and X-ray irradiation were performed on day 15 chick embryo, with the endpoint being day 18 chick embryo. In day 15 chick embryo, an X-ray irradiation dose of equal or less than 10 Gy did not cause significant tumor growth suppression. Intravenous administration of equal or less than 1.0 mg of etanidazole did not cause tumor growth suppression. Neither doses of equal or less than 8 Gy of irradiation nor 1.0 mg of etanidazole caused fatality of the chick embryo. On the basis of these results, we evaluated the radiosensitizing effect of a combination treatment with 8 Gy of irradiation and 1.0 mg of etanidazole. As noted above, 1.0 mg of etanidazole alone and 8 Gy of irradiation alone did not show tumor growth suppression. In contrast, a combination treatment with 8 Gy of irradiation and 1.0 mg of etanidazole showed 35% of significant tumor growth suppression. Thus, we succeeded in evaluating the in vivo radiosensitizing activity of etanidazole using tumor-bearing chick embryo. These results suggest that the use of tumor-bearing chick embryo may be part of a promising system for evaluating radiosensitizing activity. (Keyword) Tumor-bearing chick embryo / In vivo / Hypoxic cell radiosensitizer / Etanidazole / Radiosensitizing activity (Link to Publication Site) ● Publication site (DOI): 10.1269/jrr.10122 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21436611 ● Search Scopus @ Elsevier (PMID): 21436611 ● Search Scopus @ Elsevier (DOI): 10.1269/jrr.10122 (DOI: 10.1269/jrr.10122, PubMed: 21436611)
3.	Eiji Nakata, Yoshihiro Yukimachi, Yoshijiro Nazumi, Yoshihiro Uto, Hiroshi Maezawa, Toshihiro Hashimoto, Yasuko Okamoto and Hitoshi Hori : A newly designed cell-permeable SNARF derivative as an effective intracellular pH indicator., Chemical Communications, Vol.46, No.20, 3526-3528, 2010. (Summary) We have successfully developed a new cell-permeable SNARF derivative that is activated inside the cell by ester hydrolysis and is notable for having reduced background fluorescence. (Link to Publication Site) ● Publication site (DOI): 10.1039/c003167d (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20379600 ● Search Scopus @ Elsevier (PMID): 20379600 ● Search Scopus @ Elsevier (DOI): 10.1039/c003167d (DOI: 10.1039/c003167d, PubMed: 20379600)
4.	Masafumi Harada, Hitoshi Kubo, Takamasa Abe, Hiroshi Maezawa and Hideki Otsuka : Selection of endogenous 13C substrates for observation of intracellilar metabolism using the dynamic nuclear polarization technique, Japanese Journal of Radiology, Vol.28, No.2, 173-179, 2010. (Summary) The aim of this study was to select a suitable substrate candidate for dynamic nuclear polarization (DNP) studies and demonstrate its utility for evaluating intracellular metabolism. Hyperpolarized substances included 1-(13)C-pyruvate (Pyr), 1-(13)C-glucose (Glc), and 1-(13)C-acetate. A DNP polarizer and a 600-MHz vertical small-bore scanner were used for (13)C-MR spectroscopic measurements. After polarization for 1 h, the dissolved solution was injected via a capillary line into the nuclear magnetic resonance tube in the scanner. The sequential spectra of the hyperpolarized (13)C-labeled substrates were acquired in durations of more than 120 s, and a thermal spectrum was obtained more than 1 h thereafter. FM3A cancer cells of mammary tumors were cultured for intracellular detection of the hyperpolarized (13)C-substances. The greatest sensitivity was found using Pyr with the longest T1 decay (51.5 s); and remarkably, the least sensitivity was observed using Glc with a signal decay of less than 2 s. An effective increase in sensitivity was shown using the other substances. The hyperpolarized intracellular study using (13)C-Pyr showed distinct elevation of lactate levels. The DNP technique is useful for evaluating intracellular metabolism. However, Glc is not suitable for use with the DNP technique. (Keyword) 13C-MRS / DNP / pyruvate / glucose / Tumor cells (Link to Publication Site) ● Publication site (DOI): 10.1007/s11604-009-0390-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20182855 ● Summary page in Scopus @ Elsevier: 2-s2.0-77649217623 (DOI: 10.1007/s11604-009-0390-8, PubMed: 20182855, Elsevier: Scopus)
5.	Masanori Tomita, Munetoshi Maeda, Hiroshi Maezawa, Noriko Usami and Katsumi Kobayashi : Bystander Cell Killing in Normal Human Fibroblasts is Induced by Synchrotron X-ray Microbeams, Radiation Research, Vol.173, No.3, 380-385, 2010. (Summary) Abstract The radiation-induced bystander response is defined as a response in cells that have not been directly targeted by radiation but that are in the neighborhood of cells that have been directly exposed. In the work described here, it is shown that bystander cell killing of normal human fibroblast WI-38 cells was induced by synchrotron microbeam X radiation. Cell nuclei in confluent WI-38 cells were irradiated with the microbeam. All of the cells on the dish were harvested and plated 24 h after irradiation. It was found that the bystander cell killing effect showed a parabolic relationship to the radiation dose when five cells were irradiated. At doses above 1.9 Gy, the surviving fraction increased to approximately 1.0. This suggests that induction of bystander cell killing may require some type of activity in the targeted cells, because the dose resulting in 37% cell survival was about 2.0 Gy. Bystander cell killing was suppressed by a pretreatment with aminoguanidine [an inhibitor of inducible nitric oxide (NO) synthase] or carboxy-PTIO (a scavenger of NO). These results suggest that NO is the chief initiator/mediator of bystander cell killing induced by X-ray microbeams. (Keyword) bystander / human fiblobrasts / synchrotron / microbeams / X-rays (Link to Publication Site) ● Publication site (DOI): 10.1667/RR1995.1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20199223 ● Search Scopus @ Elsevier (PMID): 20199223 ● Search Scopus @ Elsevier (DOI): 10.1667/RR1995.1 (DOI: 10.1667/RR1995.1, PubMed: 20199223)
6.	Eiji Nakata, Yukimachi Yoshihiro, Kariyazono Hirokazu, Im Seongwang, Abe Chiaki, Yoshihiro Uto, Hiroshi Maezawa, Hashimoto Toshihiro, Okamoto Yasuko and Hitoshi Hori : Design of a bioreductively-activated fluorescent pH probe for tumor hypoxia imaging, Bioorganic & Medicinal Chemistry, Vol.17, No.19, 6952-6958, 2009. (Summary) We have designed and evaluated UTX-12 as a novel fluorescent pH probe for tumor hypoxia imaging. UTX-12 consists of a p-nitro benzyl moiety, which is a latent hypoxia-selective leaving group activated by nitro reduction, directly linked to SNARF. Although UTX-12 itself is colorless and non-fluorescent in aqueous solution, nitro reduction triggers the release of SNARF which has well-characterized long wavelength absorption and fluorescence that is sensitive to pH. The resultant SNARF, released intracellularly by enzymatic reduction of UTX-12, allows measurement of pH by pH-dependent dual emission shifts. UTX-12 showed clear differences in fluorescence behavior between hypoxic and aerobic conditions in liver microsomes and inside V79 cells. These data are confirmation that UTX-12 is biologically reduced inside tumor cells and the released SNARF should monitor intracellular pH of tumor cells selectively with reduced background signal. (Keyword) Fluorescent pH probe / Tumor hypoxia / Fluorescent imaging / Bioreductive activation / Nitro reduction (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bmc.2009.08.037 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19736018 ● Search Scopus @ Elsevier (PMID): 19736018 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2009.08.037 (DOI: 10.1016/j.bmc.2009.08.037, PubMed: 19736018)
7.	Minoru Sakama, Takuya Saze, 谷井喬, Hiroshi Maezawa, 前田幸志, 佐藤一雄, Eiichi Honda and Hiromu Nishitani : 医療用自己遮蔽型PETサイクロトロン及び電子リニアックにおける中性子束の箔放射化法による測定, Japanese Journal of Radiation Safety Management, Vol.7, No.2, 138-147, 2008. (Keyword) radiation (Link to Publication Site) ● Publication site (DOI): 10.11269/jjrsm2001.7.138 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680373971712 ● Search Scopus @ Elsevier (DOI): 10.11269/jjrsm2001.7.138 (DOI: 10.11269/jjrsm2001.7.138, CiNii: 1390282680373971712)
8.	Takashi Nakae, Yoshihiro Uto, Motoko Tanaka, Haruna Shibata, Eiji Nakata, Masahide Tominaga, Hiroshi Maezawa, Toshihiro Hashimoto, Kenneth L. Kirk, Hideko Nagasawa and Hitoshi Hori : Design, synthesis, and radiosensitizing activities of sugar-hybrid hypoxic cell radiosensitizers, Bioorganic & Medicinal Chemistry, Vol.16, No.2, 675-682, 2008. (Summary) We have designed sugar-hybrid TX-1877 derivatives conjugated with sugar moieties including β-glucose (β-Glc), β-galactose (β-Gal), α-mannose (α-Man) and N-acetyl-β-galactosamine (β-GalNAc). Compound 1 (TX-1877) was glycosylated with appropriate peracetylated sugars using BF3-OEt2 to give acetylated sugar-hybrids, 5 (TX-2244), 6 (TX-2245), 7 (TX-2246), and 10 (TX-2243). Removal of the acetyl groups afforded the sugar-hybrids having free hydroxyl groups, 11 (TX-2141), 12 (TX-2218), 13 (TX-2217) and 14 (TX-2068). We evaluated their radiosensitizing activities by an in vitro radiosensitization assay. All free hydroxyl hybrids have lower enhancement ratio (ER) values (ER 1.43) and lower n-octanol/water partition coefficient (Poct) values (Poct < 1.00 × 10-2) than does 1 (TX-1877, ER = 1.75, Poct: 5.60 × 10-2). All acetylated hybrids have similar Poct values (3.55 × 10-2 1.05 × 10-1) to 1 (TX-1877) and have improved ER values (ER 1.47) compared to the hybrids having free hydroxyl groups. Among these, 5 (TX-2244) is the most active radiosensitizer (ER = 2.30). We found a good correlation (r = 0.866) between the magnitude of Poct (logPoct) and the ER value of 5 (TX-2244), 6 (TX-2245), 7 (TX-2246), 10 (TX-2243) and 1 (TX-1877), suggesting that increasing the hydrophobicity is reflected in increased in vitro radiosensitizing activity. In the present study, we have succeeded in producing sugar-hybrid hypoxic cell radiosensitizers that have an increased radiosensitizing activity that does not depend on increased hydrophobicity. (Keyword) Hypoxic cell radiosensitizers / Sugar-hybrids / Electronic states / Hydrophobicity (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bmc.2007.10.035 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18029186 ● Search Scopus @ Elsevier (PMID): 18029186 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmc.2007.10.035 (DOI: 10.1016/j.bmc.2007.10.035, PubMed: 18029186)
9.	Rie Matsushima, Akira Takahashi, Yutaka Nakaya, Hiroshi Maezawa, Mari Miki, Youichi Nakamura, Fumitaka Ohgushi and Susumu Yasuoka : Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway., American Journal of Physiology. Lung Cellular and Molecular Physiology, Vol.290, No.2, 385-395, 2006. (Summary) Human airway trypsin-like protease (HAT) was isolated from airway secretions and localized to bronchial epithelial cells by immunohistochemistry. In the present study, we examined whether HAT could stimulate DNA synthesis and proliferation of primary human bronchial fibroblasts (HBF). HAT significantly stimulated the proliferation of HBF by 20-55%, a level similar to that of the mitogenic activity of lung mast cell tryptase (MCT). HAT also stimulated the incorporation of [3H]thymidine in HBF, and this HAT-induced DNA synthesis was abolished by leupeptin. Protease-activated receptor-2 (PAR-2) mRNA was expressed and localized to the cell surface in HBF. PAR-2 activating peptide (AP) also enhanced DNA synthesis, and both HAT and PAR-2 AP induced receptor internalization, similar to the response to trypsin. Pretreatment of HBF with anti-PAR-2 antibody significantly suppressed both HAT and PAR-2 AP-induced DNA synthesis. In addition, HAT and PAR-2 AP induced intracellular Ca2+ mobilization in HBF. The HAT-induced increase in Ca2+ was desensitized by pretreatment with trypsin or PAR-2 AP. U0126, a specific MAPK inhibitor, completely inhibited HAT-induced DNA synthesis as well as HAT-induced phosphorylation of MAPK. The effect of HAT and MCT together was additive, whereas the effect of HAT and insulin together on HBF DNA synthesis was synergistic. These results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2-dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts. (Keyword) trypsin-like protease / HAT / PAR--2 / bronchial fibroblasts (Link to Publication Site) ● Publication site (DOI): 10.1152/ajplung.00098.2005 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16199437 ● Summary page in Scopus @ Elsevier: 2-s2.0-33644833762 (DOI: 10.1152/ajplung.00098.2005, PubMed: 16199437, Elsevier: Scopus)
10.	Katsumi Kobayashi, Noriko Usami, Kotaro Hieda, Kahoru Takakura, Hiroshi Maezawa and Tohru Hayashi : Development of microbeam irradiation system for radiobiology, Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol.467-468, 1329-1332, 2001. (Link to Publication Site) ● Publication site (DOI): 10.1016/S0168-9002(01)00659-3 (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-34447648049 (DOI: 10.1016/S0168-9002(01)00659-3, Elsevier: Scopus)
11.	Yoshiya Furusawa, Hiroshi Maezawa, Kahoru Takakura, Katsumi Kobayashi and Kotaro Hieda : Radiolytic products of bromodeoxyuridine in solids by Co-60 gamma-rays and monoenergetic soft x-rays at the k-absorption edge of bromine., Acta Oncologica, Vol.35, No.7, 877-882, 1996. (Summary) In order to investigate DNA damage due to Auger cascades in bromodeoxyuridine (BrdU), BrdU mixed with other nucleosides, as a model of DNA, was irradiated in solids by gamma-rays and monoenergetic x-rays at around the K-absorption edge of bromine (13.47 keV). The main products of BrdU were deoxyuridine produced through debromination, and bromouracil produced through the decomposition of a sugar group. The rates of the debromination and the nucleobases release of additives were markedly increased in the mixed sample. This observation indicated that the additives surrounding BrdU efficiently supplied protons and then decomposed. The major products by x-rays were the same as those by gamma-rays, indicating that Auger cascades in bromine atoms did not produce specific products. The production rates for all products from the mixed sample were about 2.5 times higher at 13.51 (above the K-absorption edge) keV than at 13.43-keV x-rays. (Keyword) Bromodeoxyuridine / Bromouracil / Chromatography, High Pressure Liquid / Cobalt Radioisotopes / Deoxyuridine / Linear Energy Transfer / Magnetic Resonance Spectroscopy / X-Rays (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9004766 ● Search Scopus @ Elsevier (PMID): 9004766 (PubMed: 9004766)
12.	Hiroshi Maezawa, Yoshiya Furusawa, Katsumi Kobayashi, Kotaro Hieda, Masao Suzuki, Noriko Usami, Akinari Yokoya and Tomoyuki Mori : Lethal effect of k-shell absorption of intracellular phosphorus on wild-type and radiation sensitive mutants of Escherichia coli., Acta Oncologica, Vol.35, No.7, 889-894, 1996. (Summary) The present study was conducted to clarify the lethality of Auger cascades induced by the K-shell photoabsorption of phosphorus in Escherichia coli. Killing of wild-type and radiation-sensitive mutants of E. coli was examined. Three x-ray energies were chosen for irradiation; at 2.153 keV: the resonance peak of K-shell photoabsorption of phosphorus; at 2.146 and 2.160 keV: off-peak. Enhancement ratio, which was defined as the ratio of the killing sensitivity of 2.153 keV to that at 2.146 keV, were 1.32 to 1.54 for examined strains. Increment of absorbed energy calculated in entire cells for 2.153 keV radiation could not explain the degree of observed enhancement of killing. Lethality of Auger cascades depended on the killing sensitivity with x-rays which did not induce Auger cascades. The lethality for wild-type was lower than that for recombination repair-deficient mutants. It was concluded that one part of damages produced by Auger cascades was repaired in wild-type strains. (Keyword) Absorption / DNA Repair / DNA, Bacterial / Escherichia coli / Linear Energy Transfer / Mutation / phosphorus / Recombination, Genetic (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9004768 ● Search Scopus @ Elsevier (PMID): 9004768 (PubMed: 9004768)
13.	Kotaro Hieda, Taisuke Hirono, Akira Azami, Masao Suzuki, Yoshiya Furusawa, Hiroshi Maezawa, Noriko Usami, Akinari Yokoya and Katsumi Kobayashi : Single- and double-strand breaks in pBR322 plasmid DNA by monochromatic X-rays on and off thr K-absorption peak of phosphorus., International Journal of Radiation Biology, Vol.70, No.4, 437-445, 1996. (Summary) Using a synchrotron irradiation system pBR322 plasmid DNA was irradiated under vacuum by monochromatic X-rays having five specific photon energies (2.147, 2.153, 2.159, 2.168 and 2.199 keV) both on and off the K-absorption peak (2.153 keV) of phosphorus. The single- and double-strand breaks (ssb and dsb) were measured as conversions of the closed circular form of DNA (form I) to open circular (form II) and linear (form III) forms respectively. Exposures to induce one strand break per molecule were lowest at the peak (2.153 keV), and highest at 2.147 keV; the ratios were 2.7 for ssb and 3.0 for dsb. The exposures for dsb were 21-26 times higher than those for ssb. When the exposures were converted to absorbed doses in grays the absorbed doses per ssb were almost independent of photon energy. This result indicates that a certain absorbed dose was necessary to induce a ssb, regardless of whether photons were absorbed by the K-shell of phosphorus or by other shells, or by other atoms. However, the absorbed dose per dsb at 2.147 keV was 1.17 times higher than that averaged over four X-ray energies above 2-153 keV, indicating that the K-shell absorption, and the subsequent Auger event, efficiently induce dsb. The results are also discussed concerning the number of photo-absorptions of the constituent atoms per DNA strand break. (Keyword) Animals / Cattle / physical chemistry / DNA Damage / DNA, Bacterial / DNA, Single-Stranded / Dose-Response Relationship, Radiation / phosphorus / Physicochemical Phenomena / Plasmids / Spectrometry, X-Ray Emission / X-Rays (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8862455 ● CiNii @ National Institute of Informatics (CRID): 1361418520848000128 ● Search Scopus @ Elsevier (PMID): 8862455 (PubMed: 8862455, CiNii: 1361418520848000128)
14.	Yosh Maruyama, Muneyasu Urano, Hiroshi Maezawa and Jose Feola : Californium-252 survival curve for model solid FSa-II tumor in vivo: dose per session and therapeutic efficacy., Endocurietherapy/Hyperthermia Oncology, Vol.11, No.1, 37-42, 1995.
15.	Yukio Ohizumi, Hiroshi Maezawa and Tomoyuki Mori : Synergistic effects of hyperthermia and intratumorous injection on anti-cancer drugs., The Tokai Journal of Experimental and Clinical Medicine, Vol.18, No.3-6, 139-144, 1993.
16.	Yoshiya Furusawa, Hiroshi Maezawa, Kenshi Suzuki, Yoko Yamamoto, Katsumi Kobayashi and Kotaro Hieda : Uracil-DNA glycosylase produces excess lethal damage induced by an Auger cascade in BrdU-labelled bacteriphage T1., International Journal of Radiation Biology, Vol.64, No.2, 157-164, 1993.
17.	Hiroshi Maezawa, Ka-Ho Wong and Muneyasu Urano : Radiosensitivity of mouse skin epithelial cell line established in serum-free culture: An alternative to animal use., International Journal of Radiation OncologyBiologyPhysics, Vol.24, No.3, 533-541, 1992.
18.	Ka-Ho Wong, Hiroshi Maezawa and Muneyasu Urano : Comparative Study of Thermoradiosensitization by misonidazole and metronidazole in vivo: anti tumour effect and pharmacokinetics., International Journal of Hyperthermia., Vol.8, No.5, 645-658, 1992.
19.	Yoshiya Furusawa, Hiroshi Maezawa, Kenshi Suzuki, Katsumi Kobayashi, Masao Suzuki and Kotaro Hieda : Inactivation of bacteriophage T1 by the Auger wffect following phosphorus resonance absorption of monoenergetic synchrotron radiation., Biophysical Aspects of Auger Processes. AAPM Symposium Series., Vol.8, 37-50, 1992.
20.	Masaharu Hosi, Schuzo Uehara, Osamu Yamamoto, Shouzo Sawada, Katsumi Kobayashi, Hiroshi Maezawa, Yoshiya Furusawa, Kotaro Hieda and Takashi Yamada : Iron(II) sulphate (Fricke solution) oxidation yields for 8.9 and 13.6 keV X-rays from synchrotron radiation., International Journal of Radiation Biology, Vol.61, No.1, 21-27, 1992.

Academic Paper (Unrefereed Paper):

1.	Rie Matsushima, Akira Takahashi, Yutaka Nakaya, Mari Miki, Yoichi Nakamura, Fumiko Michishige, Sumiko Yoshinaga, Hiroshi Maezawa and Susumu Yasuoka : Tripsin-like activities and human airway trypsin-like protease (HAT) levels in airway secretions from healthy subjects and patients with chronic airway diseases., Proceeding of Airway Secretion Research, Vol.7, 15-22, 2005. (Keyword) Trypsin-like protease / HAT / airway secretions / chronic airway diseases
2.	Katsumi Kobayashi, Noriko Usami, Hiroshi Maezawa, Tohru Hayashi, Kotaro Hieda and Kahoru Takakura : Development of photon microbeam irradiation system for radiobiology, International Congress Series, Vol.1258, 207-211, 2003.
3.	Mari Miki, Youichi Nakamura, Saburo Sone, Mitsugu Ikebe, Sumiko Yoshinaga, Eriko Harada, Fumiko Michishige, Toshiko Terao, Hiroshi Maezawa and Susumu Yasuoka : Effect of human airway trypsin-like protease (HAT) on proliferation of normal bronchial epithelial cells and normal lung fibroblasts., Proceeding of Airway Secretion research, Vol.3, 15-24, 2001.
4.	Kouichi Ando, Masao Suzuki and Hiroshi Maezawa : Mutation induction, cell killing and in vivo skin reaction after fractionated irradiation with carbon ions., Radiation Research, Vol.2, 745-748, 2000. (Keyword) heavy ions / Mutation / Skin reaction

Academic Letter:

1.	Eiji Nakata, Yoshijiro Nazumi, Yoshihiro Yukimachi, Yoshihiro Uto, Hiroshi Maezawa, Toshihiro Hashimoto, Yasuko Okamoto and Hitoshi Hori : Synthesis and photophysical properties of new SNARF derivatives as dual emission pH sensors, Bioorganic & Medicinal Chemistry Letters, Vol.21, No.6, 1663-1666, 2011. (Summary) We report the synthesis and properties of two new seminaphthorhodafluor (SNARF) derivatives, SNARF-F and SNARF-Cl. Both these derivatives exhibit typical red shifts of absorption and fluorescence, and higher cell permeability as compared to traditional SNARF, while the pH-dependent dual-emission characteristics are well retained. In particular, the lower pK(a) (7.38) of SNARF-F makes it more suitable than traditional SNARF derivatives for intracellular applications. (Keyword) Benzopyrans / Fluorescent Dyes / Hydrogen-Ion Concentration / Photochemistry / Spectrometry, Fluorescence (Link to Publication Site) ● Publication site (DOI): 10.1016/j.bmcl.2011.01.105 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21324690 ● Search Scopus @ Elsevier (PMID): 21324690 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bmcl.2011.01.105 (DOI: 10.1016/j.bmcl.2011.01.105, PubMed: 21324690)

Review, Commentary:

1.	Hitoshi Kubo, Masafumi Harada, Hiroshi Maezawa and Takamasa Abe : 13C-NMR測定による代謝情報可視化の試み, Radiation Biology Research Communications, Vol.44, No.4, 447-459, Dec. 2009. (Keyword) 13C / NMR / metabolic (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520290882659493888 (CiNii: 1520290882659493888)
2.	安部千秋, Yoshihiro Uto, 遠藤良夫, 新元優也, 中島宏一郎, 佐野圭一郎, 佐々木有紀, 皆巳和賢, Hiroshi Maezawa, 慎一郎増永, Eiji Nakata and Hitoshi Hori : 次世代動物実験系としての腫瘍移植鶏卵の構築と放射線照射による腫瘍成長阻害活性, Radiation Biology Research Communications, Vol.44, No.2, 233-241, Jun. 2009. (Keyword) 腫瘍移植鶏卵 / 放射線増感剤 / 低酸素がん細胞 / ハイスループットスクリーニング / in ovo試験 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1520009408165390592 (CiNii: 1520009408165390592)
3.	Hitoshi Kubo, Masafumi Harada, Hiroshi Maezawa and Takamasa Abe : 13C-NMR, 放射線生物研究, Vol.44, No.4, 447-459, 2009. (Keyword) 13C / NMR / metabolism / 超偏極 / 可視化
4.	Masao Suzuki and Hiroshi Maezawa : マイクロビーム放射線の利用と生物作用の特色, Radiation Biology Research Communications, Vol.37, No.3, 316-333, Sep. 2002.
5.	Hiroshi Maezawa : Biological effects of heavy-ion beams and it's application for radiotherapy, Shikoku Acta Medica, Vol.58, No.3, 153-161, Jun. 2002. (Keyword) heavy ions / radiation therapy (Tokushima University Institutional Repository) ● Metadata: 110543 (Tokushima University Institutional Repository: 110543)

Proceeding of International Conference:

1.	Yoshihiro Tanaka, Hitoshi Ikushima, Hiroshi Maezawa and Kazuya Kondo : Usefulness of diagnostic imaging in neoadjuvant chemoradiation therapy for non-small cell lung cancer, ESTRO 31, May 2012.
2.	Hiroshi Maezawa and Wataru Sugimoto : Reduction of glioma cell migration by X-ray induced bystander effects, Abstracts(Web) 14th International Congress of Radiation Research, 364, Warsaw, Aug. 2011. (Keyword) radiation therapy / bystander effect / migration / radiation therapy / radiation
3.	Yoshihiro Uto, Chiaki Abe, Takashi Nakae, Yoshio Endo, Masahide Tominaga, Hiroshi Maezawa, Eiji Nakata and Hitoshi Hori : Systems biology-based drug design of sugar-hybrid hypoxic cell radiosensitizers using the tumor-implantable chick embryo model, PACIFICHEM 2010, Honolulu, Dec. 2010.
4.	Hitoshi Kubo, Masafumi Harada, Abe Takamasa, Hiroshi Maezawa and Hiromu Nishitani : Evaluation of the Early Metabolic Response Induced by 5-Fluorouracil on Mouse Mammary Cancer Cells Under Fasting Conditions Using Hyperpolarized 13C-Labeled Pyruvate., Joint Annual Meeting ISMRM-ESMRMB 2010, Stockholm, Sweden, May 2010.
5.	Eiji Nakata, Yukimachi Yoshihiro, Nazumi Yoshijiro, Abe Chiaki, Yoshihiro Uto, Hiroshi Maezawa and Hitoshi Hori : Design of a Bioreductively-Activated Fluorescent pH Probe for Tumor Hypoxia Imaging, SJBC2009, Tokyo, Sep. 2009.
6.	Katsumi Kobayashi, Noriko Usami, Hiroshi Maezawa, Kotaro Hieda, Kahoru Takakura and Yoshiya Furusawa : X-ray microbeam irradiation systems at the Photon Factory-Present Status and Future Plan-, New York, Mar. 2006. (Keyword) microbeam / soft X-rays
7.	Katsumi Kobayashi, Noriko Usami, Hiroshi Maezawa, Tohru Hayashi, Kotaro Hieda and Kahoru Takakura : Development of photon microbeam irradiation system for radiobiology., Abstracts of 6th International Workshop / 12th LH Gray Workshop. Microbeam Probes of Cellular Radiation Response., 72-74, Oxford, Mar. 2003.
8.	Hiroshi Maezawa : Cellular damages by photon-induced Auger cascades, Abstracts of International Symposium on Innovative Technology for Radiation Risk Study 2003, 28-29, Tokyo, Mar. 2003.
9.	Kouichi Ando, Masao Suzuki and Hiroshi Maezawa : Skin reaction and in vitro cecll kill after fractionated irradiation with carbon ions., Abstracts of 11th International Congress of Radiation Research, 55, Lund, Jul. 1999.
10.	Hiroshi Maezawa, Yoshiya Furusawa, Takeshi Akiba and Tomoyuki Mori : Effect of fractionation on mutation frequency of mammalian cells exposed to carbon ions., Abstracts of 11th International Congress of Radiation Research, 95, Dublin, Jul. 1999.
11.	Hiroshi Maezawa, Yoshiya Furusawa, Katsumi Kobayashi, Satoshi Imamiya and Tomoyuki Mori : Lethality on V79 cells of monoenergetic X-rays on the K-shell photoabsorption peak of phosphorus., Abstracts of 4th International Symposium on Biophysical Aspects of Auger Precesses., 29, Lund, Jul. 1999.

Proceeding of Domestic Conference:

1.	原毅弘, Yoshihiro Uto, Ayaka Nakashima, Koushirou Fukushima, Chiho Noguchi, 遠藤良夫, Hiroshi Maezawa, Masahide Tominaga, 福本修一 and Hitoshi Hori : 発育鶏卵を用いたオオバギ葉抽出物の放射線防護活性の評価, 第19回癌治療増感研究会, Jun. 2013.
2.	Hitoshi Ikushima and Hiroshi Maezawa : 192-Ir高線量率密封小線源治療における細胞致死効果に対する線量率効果, 日本放射線腫瘍学会小線源部会第15回学術大会, May 2013.
3.	Yoshihiro Uto, 皆巳和賢, 原田浩, 遠藤良夫, Hiroshi Maezawa, 慎一郎増永 and Hitoshi Hori : 解糖系からみた癌増感のターゲット:糖修飾放射線増感剤のメディシナルケミストリー, 第15回癌治療増感研究シンポジウム, Feb. 2013.
4.	Yoshihiro Uto, 田中大地, 野口智帆, 原田浩, 遠藤良夫, Hiroshi Maezawa, 慎一郎増永 and Hitoshi Hori : HIF-1/GFP発現系を利用した腫瘍移植鶏卵における低酸素領域の解析と放射線による分布変化の観察, 第18回癌治療増感研究会, Jun. 2012.
5.	田中大地, Yoshihiro Uto, 安部千秋, 遠藤良夫, Hiroshi Maezawa, 原田浩, 慎一郎増永 and Hitoshi Hori : 腫瘍移植鶏卵における低酸素腫瘍の同定とetanidazoleのin vivo放射線増感活性の評価, 日本薬学会第132年会, Mar. 2012.
6.	Yoshihiro Uto, 村井絵美, 寺岡瑞絵, Hiroshi Maezawa and Hitoshi Hori : アセチル化グルコースハイブリッド放射線増感剤TX-2244をリードとした6位修飾グルコース型放射線増感剤の分子設計, 第14回癌治療増感研究シンポジウム, Feb. 2012.
7.	Hiroshi Maezawa, 権藤賢悟, 松原隆敏, 美濃部遥, Yoshihiro Uto and Hitoshi Hori : 5フルオロウラシルの低酸素ヒト肺がん細胞X線致死増感効果, 日本放射線影響学会第54回大会, 120, Nov. 2011. (Keyword) radiation therapy / radiation / dose-survival curve / 放射線増感剤 / 低酸素
8.	Takaharu Kudoh, Hiroshi Maezawa, Shunsuke Furutani, Akiko Kubo and Hitoshi Ikushima : 子宮頸癌に対する 192-Ir 高線量率照射 in vitro 実験モデルの作成, 日本放射線腫瘍学会第24回学術大会, Nov. 2011.
9.	Chiaki Abe, Yoshihiro Uto, Yoshio Endo, Hiroshi Maezawa, Shin-ichiro Masunaga and Hitoshi Hori : Evaluation of the In vivo Radiosensitizing Activity of Etanidazole Using Tumor-bearing Chick Embryo, 70th Annual Meeting of the Japanese Cancer Association, Oct. 2011.
10.	Eiji Nakata, Yoshihiro Uto, Hiroshi Maezawa and Hitoshi Hori : Development of fluorescent pH probe for measuring intracellular pH of tumor hypoxic cells, 第69回日本癌学会学術総会, Sep. 2010.
11.	Hiroshi Maezawa, Hiroyuki Sato, Seiko Kim and Jun Itami : 肺がん由来細胞の遊走に対するX線及び再酸素化の効果, 第49回日本医学放射線学会生物部会学術大会講演要旨集, 15, Jul. 2010. (Keyword) 肺がん細胞 / 遊走 / X-ray / 再酸素化 / 傷つけアッセイ
12.	Yoshihiro Uto, 安部千秋, 中江崇, 村井絵美, 遠藤良夫, Masahide Tominaga, Hiroshi Maezawa, 慎一郎増永, Eiji Nakata and Hitoshi Hori : 腫瘍移植鶏卵モデルによる糖ハイブリッド放射線増感剤のin vivo放射線増感活性の評価, 第16回国際癌治療増感研究会, Jun. 2010.
13.	Eiji Nakata, Yoshihiro Yukimachi, Yoshijiro Nazumi, Yoshihiro Uto, Hiroshi Maezawa and Hitoshi Hori : 外部刺激応答型蛍光プローブの開発と低酸素細胞の選択的可視化への応用, 第16 回国際癌治療増感研究会, Jun. 2010.
14.	Eiji Nakata, 行待芳浩, 那住善治郎, Yoshihiro Uto, Hiroshi Maezawa and Hitoshi Hori : Newly designed cell-permeable SNARF derivative as an effective intracellular pH indicator, 日本ケミカルバイオロジー学会第5回年会, May 2010.
15.	行待芳浩, Eiji Nakata, Yoshihiro Uto, 那住善治郎, Hiroshi Maezawa and Hitoshi Hori : Newly designed SNARF derivative as the intracellular pH indicator, 日本薬学会第130年会, Mar. 2010.
16.	Eiji Nakata, 行待芳浩, 那住善治郎, Yoshihiro Uto, Hiroshi Maezawa and Hitoshi Hori : 細胞内pH計測に適した新規SNARF誘導体の設計とその機能評価, 日本化学会第90春季年会, Mar. 2010.
17.	Eiji Nakata, 行待芳浩, 那住善治郎, Hiroshi Maezawa, Yoshihiro Uto and Hitoshi Hori : 細胞内pH計測により適合した新規SNARF誘導体の設計, 第12回生命化学研究会, Jan. 2010.
18.	Takashi Nakae, Yoshihiro Uto, Chiaki Abe, Takeyuki Kanazono, Yuuya Shinmoto, Keiichiro Sano, Eiji Nakata, Yoshio Endo, Masahide Tominaga, Hiroshi Maezawa, Toshihiro Hashimoto, 慎一郎増永 and Hitoshi Hori : 鶏胚異種移植腫瘍モデルを基盤とした糖ハイブリッド低酸素細胞放射線増感剤の創製, 創薬懇話会2009, Dec. 2009. (Keyword) 鶏胚異種移植腫瘍モデル / 糖ハイブリッド低酸素細胞放射線増感剤
19.	Eiji Nakata, Yukimachi Yoshihiro, Nazumi Yoshijiro, Abe Chiaki, Yoshihiro Uto, Hiroshi Maezawa and Hitoshi Hori : Bioreductively-Activated Fluorescent pH Probe for Tumor Hypoxia Imaging, 第7回がんとハイポキシア研究会, Dec. 2009.
20.	赤松和季, Minoru Sakama, Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 廣田昌大, 前田幸志 and 谷井喬 : 圧延金板とイメージングプレートを用いる中性子線の視覚化, 日本放射線安全管理学会第8回学術大会, Dec. 2009.
21.	Namiko Irikura, Yoshinori Kuwahara, Hiroshi Maezawa, Hirokazu Miyoshi, Takuya Saze, 立花さやか and 合田康代 : RI施設の改修に伴う部分的な管理区域解除の事例報告, 日本放射線安全管理学会第8回学術大会, Dec. 2009.
22.	Yoshinori Kuwahara, Shunsuke Furutani, Hiroshi Maezawa, Takuya Saze, Hirokazu Miyoshi, 川口佳彦, 黒崎裕, 木下悠亮 and Shintaro Nakayama : がん治療用I-125シード放射能自動測定システムの開発, 日本放射線安全管理学会第8回学術大会, Dec. 2009.
23.	木下悠亮, Shintaro Nakayama, Ken-Ichi Fushimi, Norihiko Koori, Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 川口佳彦, Yoshinori Kuwahara, Shunsuke Furutani and 黒崎裕 : がん治療用125Iシード放射能自動測定システムの性能評価, 日本放射線安全管理学会, Dec. 2009.
24.	Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, Shunsuke Furutani, Yoshinori Kuwahara, Hiromu Nishitani, 川口佳彦, 木下悠亮 and Shintaro Nakayama : I-125シード型標準線源を用いるがん治療用密封小線源の自動定量測定, 日本放射線安全管理学会, Dec. 2009.
25.	Hirokazu Miyoshi, 合田康代, Takuya Saze, 立花さやか, Hiroshi Maezawa, Namiko Irikura and Yoshinori Kuwahara : 放射線業務におけるヒヤリとした事例-再教育訓練の効果-, Japanese Journal of Radiological Technology, Dec. 2009.
26.	Yoshihiro Uto, Chiaki Abe, Yoshio Endo, Hiroshi Maezawa, Eiji Nakata and Hitoshi Hori : Pharmacokinetic drug design of sugar-hybrid radiosensitizers using the tumor implant chick embryo model, 第68回日本癌学会学術総会, Oct. 2009. (Keyword) Pharmacokinetics / Radiosensitivity
27.	行待芳浩, Eiji Nakata, 那住善治郎, Hiroshi Maezawa, Yoshihiro Uto and Hitoshi Hori : 効果的な細胞内pHの計測を目指した改良型SNARFの設計とその評価, 第24回生体機能関連化学若手フォーラム, Sep. 2009.
28.	Eiji Nakata, 行待芳浩, 安部千秋, Yoshihiro Uto, Hiroshi Maezawa and Hitoshi Hori : がん低酸素環境を標的とした蛍光性pHプローブの開発, 第24回生体機能関連化学シンポジウム第12回バイオテクノロジーシンポジウム, Sep. 2009.
29.	Eiji Nakata, 行待芳浩, 安部千秋, Yoshihiro Uto, Hiroshi Maezawa and Hitoshi Hori : 癌低酸素環境で選択的に機能する蛍光性pHプローブの開発, 生体機能関連若手の会サマースクール2009, Jul. 2009.
30.	金世洸, 前濱慶祐, 鈴木諭, Yoshihiro Uto, Eiji Nakata, Hitoshi Hori and Hiroshi Maezawa : ピリミジン系核酸誘導体のチャイニーズハムスターV79細胞に対する放射線増感効果, 第48回日本医学放射線学会生物部会学術大会, Jul. 2009.
31.	Yoshihiro Uto, 中江崇, 安部千秋, 新元優也, 佐野圭一郎, 遠藤良夫, Masahide Tominaga, Hiroshi Maezawa, Eiji Nakata and Hitoshi Hori : 腫瘍移植鶏卵モデルによる糖ハイブリッド放射線増感剤の薬物動態解析, 第15回国際癌治療増感研究会, Jun. 2009.
32.	新元優也, Yoshihiro Uto, 遠藤良夫, 安部千秋, 中島宏一郎, 佐野圭一郎, 佐々木有紀, 皆巳和賢, Hiroshi Maezawa, 慎一郎増永, Eiji Nakata and Hitoshi Hori : 腫瘍移植鶏卵を用いた in ovo 放射線増感活性評価系の確立, 日本薬学会第129年会, Mar. 2009.
33.	金園剛行, Yoshihiro Uto, 中江崇, 柴田明奈, 中島宏一郎, 佐野圭一郎, Masahide Tominaga, Hiroshi Maezawa, Eiji Nakata and Hitoshi Hori : メチル化グルコース・糖ハイブリッド低酸素細胞放射線増感剤の分子設計, 日本薬学会第129年会, Mar. 2009.
34.	中江崇, Yoshihiro Uto, 安部千秋, 新元優也, 金園剛行, 中島宏一郎, 佐野圭一郎, Masahide Tominaga, Hiroshi Maezawa, 慎一郎増永, 遠藤良夫, Eiji Nakata and Hitoshi Hori : 腫瘍移植鶏卵モデルによる糖ハイブリッド低酸素細胞放射線増感剤TX-2244の腫瘍移行性, 日本薬学会第129年会, Mar. 2009.
35.	Yoshihiro Uto, 安部千秋, 新元優也, 中江崇, 中島宏一郎, 佐野圭一郎, 遠藤良夫, 皆巳和賢, Hiroshi Maezawa, 慎一郎増永, Eiji Nakata and Hitoshi Hori : 腫瘍移植鶏卵を用いた in ovo 放射線増感活性評価系の確立, 第11回癌治療増感研究シンポジウム, Feb. 2009.
36.	Yoshinori Kuwahara, Namiko Irikura, Hiroshi Maezawa, 立花さやか, 合田康代, Hirokazu Miyoshi and Takuya Saze : ASP.NETを利用した簡易RI在庫管理ソフトウエア開発, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
37.	森脇崇, Shintaro Nakayama, Hirokazu Miyoshi, Takuya Saze, Hiroshi Maezawa and 川口佳彦 : 3H-ATPを用いたトリチウムの飛散率と総放射能の検討, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
38.	Namiko Irikura, Yoshinori Kuwahara, Hiroshi Maezawa, Takuya Saze, Hirokazu Miyoshi, 立花さやか and 合田康代 : 徳島大学におけるRI汚染の対応, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
39.	黒崎裕, Shintaro Nakayama, Ken-Ichi Fushimi, Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 川口佳彦 and Shunsuke Furutani : スリットとシンチレータを用いるがん治療用I-125シード強度測定システムの実現可能性の検討, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
40.	熊井万里子, Minoru Sakama, Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 谷井喬, 前田幸志, 佐藤一雄, Eiichi Honda and Hiromu Nishitani : PETサイクロトロンにおける自己遮蔽体による中性子遮蔽能の検証, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
41.	Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, Shunsuke Furutani, Hiromu Nishitani, Shintaro Nakayama, 川口佳彦, 黒崎裕, 伊藤茂樹 and 西澤邦秀 : がん治療用密封小線源におけるシードイメージング定量法の進展, 日本放射線安全管理学会第7回学術大会, Dec. 2008.
42.	Minoru Sakama, Takuya Saze, 谷井喬, Hiroshi Maezawa, Eiichi Honda, Hiromu Nishitani, 佐藤一雄 and 桝本和義 : 自己遮蔽型PETサイクロトロン及び放射線治療用電子リニアック装置における中性子束の箔放射化法による測定, 第52回放射化学討論会, Dec. 2008. (Keyword) 放射線安全管理学
43.	Yoshihiro Uto, 遠藤良夫, Hiroshi Maezawa, Hideko Nagasawa and Hitoshi Hori : 腫瘍移植鶏卵を用いたin vivo放射線増感活性評価モデルの開発, 第67回日本癌学会学術総会, Oct. 2008.
44.	Minoru Sakama, Takuya Saze, 谷井喬, Hiroshi Maezawa, Eiichi Honda, Hiromu Nishitani, 佐藤一雄 and 桝本和義 : 徳島大学病院医療用自己遮蔽型PETサイクロトロン及び電子リニアックにおける中性子束の箔放射化法による測定, 第52回放射化学討論会, Sep. 2008. (Keyword) 放射線安全管理学
45.	皆巳和賢, Yoshihiro Uto, 中江崇, Eiji Nakata, Hideko Nagasawa, Hitoshi Hori and Hiroshi Maezawa : 低酸素細胞に対するニトロイミダゾールアセトアミド誘導体の放射線増感効果, 第47回日本医学放射線学会生物部会学術大会, Jun. 2008.
46.	Yoshihiro Uto, 中江崇, 佐々木有紀, 安部千秋, 中島宏一郎, 新元優也, 佐野圭一郎, 遠藤良夫, 皆巳和賢, Hiroshi Maezawa, Eiji Nakata, Hideko Nagasawa and Hitoshi Hori : 次世代動物実験系としての腫瘍移植鶏卵の構築と放射線照射による腫瘍成長阻害活性, 第14回癌治療増感研究会, Jun. 2008.
47.	中島宏一郎, 中江崇, 柴田明奈, 田中智子, Yoshihiro Uto, Masahide Tominaga, Hiroshi Maezawa, Eiji Nakata, Hideko Nagasawa and Hitoshi Hori : がんによるグルコースの高い取り込みを利用した糖ハイブリッド低酸素細胞放射線増感剤の分子設計, 日本薬学会第128年会, Mar. 2008.
48.	皆巳和賢, Yoshihiro Uto, 中江崇, Eiji Nakata, Hideko Nagasawa, Hitoshi Hori and Hiroshi Maezawa : ニトロイミダゾールアセトアミド誘導体による低酸素放射線増感効果, 第10回癌治療増感研究シンポジウム, Feb. 2008.
49.	森田新章, 加地史武, 清水友美, 山下憲一, Hirofumi Yagi, Sadamitsu Nishihara and Hiroshi Maezawa : 生物用(細胞照射用)X線発生装置の特性, 中四国放射線医療技術, No.3, 151, Jan. 2008.
50.	上野有美, Takuya Saze, 坂根仁, Yoshinori Kuwahara, Namiko Irikura, 立花さやか, Hirokazu Miyoshi, Hitoshi Kubo, Masafumi Harada and Hiroshi Maezawa : 非破壊検査手法を用いるモモ果実生理障害の観察, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
51.	Namiko Irikura, 菱本純次, 花見孝行, Takuya Saze, Hirokazu Miyoshi, Yoshinori Kuwahara and Hiroshi Maezawa : 放射性有機廃液焼却装置の運転コストについて2, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
52.	Yoshinori Kuwahara, 立花さやか, Namiko Irikura, Hirokazu Miyoshi, Takuya Saze and Hiroshi Maezawa : Excelを利用した簡易入退出管理ソフトウエアの開発, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
53.	Hirokazu Miyoshi, Namiko Irikura, Takuya Saze, Yoshinori Kuwahara and Hiroshi Maezawa : 放射線教育—親子科学教室と学校科学教室, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
54.	久保田牧子, Takuya Saze, Shunsuke Furutani, Hiromu Nishitani, 川口佳彦, 中山信太郎, Hirokazu Miyoshi, 伊藤茂樹, 西澤邦秀 and Hiroshi Maezawa : イメージングプレートによって抽出されたI-125線源像のコリメータによる変化, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
55.	谷井喬, Takuya Saze, Minoru Sakama, 坂根仁, 前田幸志, 佐藤一雄, 川口佳彦, Hirokazu Miyoshi, Hiromu Nishitani and Hiroshi Maezawa : 自己遮蔽型PETサイクロトロンに対する中性子漏洩管理, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
56.	Hirokazu Miyoshi, 立花さやか, Takuya Saze, Namiko Irikura, Yoshinori Kuwahara, Akio Adachi and Hiroshi Maezawa : コース別再教育訓練の計画と実施及びその分析続報, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
57.	Takuya Saze, Hirokazu Miyoshi, Hiroshi Maezawa, 久保田牧子, 古谷俊介, Hiromu Nishitani, 川口佳彦, 伊藤茂樹 and 西澤邦秀 : 滅菌カートリッジに封入されたがん治療用線源の簡便な品質管理, 日本放射線安全管理学会第6回学術大会, Dec. 2007.
58.	川口佳彦, Hirokazu Miyoshi, Takuya Saze, Shintaro Nakayama, Ken-Ichi Fushimi, Norihiko Koori, Namiko Irikura and Hiroshi Maezawa : イメージングプレートを使用したトリチウム飛散分布の画像化, 第44回アイソトープ・放射線研究発表会, Jul. 2007.
59.	Takuya Saze, 本田朋子, 前田恵理子, Masafumi Harada, Hitoshi Kubo, Hirokazu Miyoshi and Hiroshi Maezawa : 非破壊検査手法を用いる病変モモ果実の検出, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
60.	Yoshinori Kuwahara, 立花さやか, Namiko Irikura, Hirokazu Miyoshi, Takuya Saze, Hiroshi Maezawa and Akio Adachi : 払い出しから引き渡しまでの管理ソフトウエアの開発, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
61.	Namiko Irikura, Hirokazu Miyoshi, Takuya Saze, Yoshinori Kuwahara, 立花さやか, 合田康代, Akio Adachi and Hiroshi Maezawa : 管理区域における労働安全衛生法への対応, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
62.	Hirokazu Miyoshi, 合田康代, Takuya Saze, Namiko Irikura, Yoshinori Kuwahara and Hiroshi Maezawa : コース別再教育訓練の計画と実施及びその分析, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
63.	川口佳彦, Namiko Irikura, Takuya Saze, Shintaro Nakayama, Ken-Ichi Fushimi, Hirokazu Miyoshi and Hiroshi Maezawa : モデルルームを用いたトリチウムの飛散率・壁面分布測定, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
64.	Takuya Saze, 前田恵理子, Minoru Sakama, 坂根仁, 前田幸志, 佐藤一雄, 本田朋子, 川口佳彦, Hirokazu Miyoshi, Hiromu Nishitani and Hiroshi Maezawa : 自己遮蔽型PETサイクロトロンに対する中性子漏洩管理, 日本放射線安全管理学会第5回学術大会, Dec. 2006.
65.	Takuya Saze, Shunsuke Furutani, 伊藤茂樹, 出路静彦, 廣田昌大, 有賀英司, Hirokazu Miyoshi, Hiromu Nishitani, 西澤邦秀 and Hiroshi Maezawa : イメージングプレートを用いる前立腺がん治療用線源の品質管理測定(II), 日本放射線安全管理学会第5回学術大会, Nov. 2006.
66.	Hirokazu Miyoshi, Namiko Irikura, Takuya Saze, Yoshinori Kuwahara, 合田康代, 立花さやか, Akio Adachi and Hiroshi Maezawa : 定期検査・定期確認の事例-徳島大学アイソトープ総合センター-, 日本アイソトープ協会, Nov. 2006.
67.	Katsumi Kobayashi, Noriko Usami, Hiroshi Maezawa, Tohru Hayashi, Kotaro Hieda, Kahoru Takakura and Yoshiya Furusawa : PFにおけるマイクロビームX選照射装置の現状と改良計画, 日本放射線影響学会第49回大会講演要旨集, 82, Sep. 2006. (Keyword) microbeam / soft X-rays
68.	Noriko Usami, Katsumi Kobayashi, Toshio Mori, Takaaki Iwamoto, Hiroshi Maezawa, Kotaro Hieda, Daichi Yoshihara, Teruaki Konishi and Akihiro Takeyasu : Synchrotron X-ray microbeam irradiation system 2. Performance test by cell irradiation experiments., Abstract of 46th Annual Meeting of Japan Radiation Research Society, 128, Oct. 2003.
69.	Katsumi Kobayashi, Noriko Usami, Hiroshi Maezawa, Tohru Hayashi, Kotaro Hieda and Kahoru Takakura : Synchrotron X-ray microbeam irradiation system. 1. Outline of the system., Abstract of 46th Annual Meeting of Japan Radiation Research Society, 94, Oct. 2003.
70.	Mari Miki, Youichi Nakamura, Hiroyuki Hino, Fumitaka Okushi, Akira Takahashi, Sumiko Yoshinaga, Hiroshi Maezawa and Susumu Yasuoka : ヒト気道トリプシン様プロテアーゼ(HAT)の気道細胞内遊離Ca²⁺濃度[Ca²⁺]に対する作用, 第42回日本呼吸器学会総会プログラム, 112, Apr. 2002.
71.	Youichi Nakamura, Mari Miki, Yoshio Okano, Minoru Sakama, Sumiko Yoshinaga, Hiroshi Maezawa, Yoshihiro Takegawa and Susumu Yasuoka : ヒト気道トリプシン様プロテアーゼ(HAT)の線維芽細胞に対する影響(シンポ), 第21回気道分泌研究会抄録集, 4, Jun. 2001.
72.	Naoko Mikamo, Hideko Nagasawa, 山下真緒, 勝浦恵子, Shigenori Oka, Mariko Shimamura, Hiroshi Maezawa, Yoshihiro Uto and Hitoshi Hori : 低酸素細胞修飾剤Triazine-N-oxideの分子設計 - アポトーシス誘導活性と血管新生阻害活性 -, 日本薬学会第121年会, Mar. 2001. (Summary) 低酸素細胞修飾剤Triazine-N-oxideの分子設とそのアポトーシス誘導活性及び血管新生阻害活性について報告した．
73.	Hiroshi Maezawa, Yoshiya Furusawa, Katsumi Kobayashi and Satoshi Imamiya : リン原子内殻電離により培養細胞に生成される潜在的致死損傷の回復, 日本放射線影響学会第43回大会講演要旨集, 128, Sep. 2000.
74.	Hiroshi Maezawa : マイクロビームによる研究のレビューと展望, 日本放射線影響学会第43回大会講演要旨集, 66, Aug. 2000.
75.	葛西宗江, Hideko Nagasawa, 山下真緒, Yoshihiro Uto, Hitoshi Hori, 太田一郎, 松浦成昭, Hiroshi Maezawa and 稲山誠一 : 血管内皮細胞遊走阻害活性を有する低酸素細胞放射線増感剤TX-1877及びその誘導体の分子設計·合成·生物活性, 第6回癌治療増感研究会, May 2000. (Summary) 血管内皮細胞遊走阻害活性を有する低酸素細胞放射線増感剤TX-1877及びその誘導体の分子設計·合成·生物活性について発表した．
76.	Hiroshi Maezawa, Keiko Hamada, Soko Kasai, Saharuddin Mohamad, Hideko Nagasawa, Yoshihiro Uto, Hitoshi Hori and Seiichi Inayama : 低酸素細胞増感剤TX1877によるマウス腹腔マクロファージの活性化, 日本医学放射線学会第38回生物部会学術大会抄録集, 27, Apr. 1999. (Summary) 多機能性放射線増感剤TX1877によるマウス腹腔マクロファージの活性化について報告した．

Et cetera, Workshop:

1.	Hirokazu Miyoshi, Hiroshi Maezawa, Yoshinori Kuwahara, Takuya Saze, 松田尚樹, 蕪木宏行, Yasuhiko Morita, Seiji Iwamoto, Hideki Otsuka, 佐藤一雄, Eiichi Honda, Namiko Irikura, 合田康代 and 立花さやか : 徳島大学アイソトープ総合センター, 徳島大学アイソトープ総合センター, No.7, 1-44, Aug. 2008.
2.	Hirokazu Miyoshi, Hiroshi Maezawa, Takuya Saze, Yoshinori Kuwahara, Namiko Irikura, 立花さやか and Akio Adachi : 徳島大学アイソトープ総合センター概要2007年度版, Apr. 2007.
3.	Hirokazu Miyoshi, Hiroshi Maezawa, Akio Adachi, Takuya Saze, Namiko Irikura, Yoshinori Kuwahara, 立花さやか, Tatsuhiro Ishida, Akihiko Tsuji, Takao Hanabusa, Toshihiro Moriga, 鬼島明洋, Eiichi Honda, Seiji Iwamoto, 佐藤一雄, Shunsuke Furutani and Yasuhiko Morita : 徳島大学アイソトープ総合センターニュース, 徳島大学アイソトープ総合センターニュース, Vol.6, 1-42, Mar. 2007.
4.	川口佳彦, Hirokazu Miyoshi, Takuya Saze, Namiko Irikura, Shintaro Nakayama, Norihiko Koori, Ken-Ichi Fushimi and Hiroshi Maezawa : イメージングプレートを使用したトリチウム飛散測定の画像化, 弥生研究会「放射線検出器とその応用」プログラム, Feb. 2007.
5.	Yoshiko Kawaguchi, Shintaro Nakayama, Ken-Ichi Fushimi, Norihiko Koori, Hirokazu Miyoshi, Takuya Saze, Namiko Irikura and Hiroshi Maezawa : Spread of Tritium Distribution in the Model Room Obtained using Imaging Plate, KEK Proceedings, 2007.

Report:

1.	Hirokazu Miyoshi, Takuya Saze, Yoshinori Kuwahara, Namiko Irikura and Hiroshi Maezawa : ファミリーサイエンス教室(あすたむらんど徳島), 平成19年度地域連携事業成果報告書, 28, Mar. 2008.
2.	Hiroshi Maezawa : ヒト気道トリプシン様酵素の気道細胞に対する生物作用機序とその病態的意義の解明., 平成13年度∼15年度科学研究費補助金(基盤研究(B)(2))研究成果報告書, Tokushima, Feb. 2004.
3.	Hiroshi Maezawa : 放射線間質性肺炎の予防に対する肝細胞増殖因子の投与効果に関する研究, 平成8年度∼平成10年度化学研究費補助金(基盤研究(C)(2))研究成果報告書, Tokushima, Sep. 1999.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Molecular biologic effect of neoadjuvant chemoradiotherapy followed by surgery for non-small cell lung cancer (Project/Area Number: 22591386 )
Study of Bystander Effects on Lung Epithelial Cells Irradiated with Monochromatic X-ray Microbeam. (Project/Area Number: 17510047 )
Bystander effects induced with inner shell ionization followed by Auger effects (Project/Area Number: 17201016 )
Research on biological effects in low dose region by using synchrotron X-ray microbeam irradiation system (Project/Area Number: 14208069 )
MECHANISMS OF BIOLOGICAL EFFECTS OF HUMAN AIRWAY TRYPSIN-LIKE PROTEASE (HAT) ON BRONCHIAL CELLS AND PATHOLOGICAL ROLES OF HAT IN THE AIRWAY DISEASES (Project/Area Number: 13557052 )
The Effect of Hepatocyte Growth Factor on the Development of Lung Injury Induced by Thoracic Irradiation in Mice. (Project/Area Number: 08671053 )
Predictive assays of normal tissue damage using molecular, cellular and tissue methods (Project/Area Number: 08457247 )
Relationship of oncogene expression and radiosensitivity on mammalian cells. (Project/Area Number: 04454297 )
Study on the biological properties of nitroimidazole nucleoside analogs as a new hypoxic cell radiosensitizer. (Project/Area Number: 01480277 )
Development of a grazing incidence soft X-ray monochromator for radiation biology studies. (Project/Area Number: 61880018 )
Studies of biological effects of vacuum ultraviolet radiation above 50 nm. (Project/Area Number: 61304066 )
Search by Researcher Number (00138653)

Professor Emeritus : Maezawa, Hiroshi

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)