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研究活動

専門分野

研究テーマ

著書・論文

著書:

1. 太田 房雄, 内海 莢, 大西 克成, 金政 泰弘, 斉藤 肇, 高木 篤, 新居 四郎, 内海 爽, 他 :
第3章 グラム陰性好気性捍桿菌および球菌,Ⅲナイセリア属,
医歯薬出版 株式会社, 東京, 2003年11月.
2. 太田 房雄, 内海 莢, 大西 克成, 金政 泰弘, 斉藤 肇, 高木 篤, 新居 四郎, 内海 爽, 他 :
第1章 グラム陽性球菌,
医歯薬出版 株式会社, 東京, 2003年11月.

学術論文(審査論文):

1. Keiko Kataoka, Sachiko Ogasa, Tomomi Kuwahara, Yoshimi Bando, Mari Hagiwara, Hideki Arimochi, Shuusuke Nakanishi, Teruaki Iwasaki and Yoshinari Ohnishi :
Inhibitory effects of fermented brown rice on induction of acute colitis by dextran sulfate sodium in rats.,
Digestive Diseases and Sciences, Vol.53, No.6, 1601-1608, 2008.
(DOI: 10.1007/s10620-007-0063-3,   PubMed: 17957470)
2. Hideki Arimochi, Kyoji Morita, Keiko Kataoka, Shusuke Nakanishi, Tomomi Kuwahara and Yoshinari Ohnishi :
Suppressive effect of Clostridium perfringens-produced heat-stable substance(s) on proliferation of human colon adenocarcinoma HT29 cells in culture,
Cancer Letters, Vol.241, No.2, 228-234, 2006.
(DOI: 10.1016/j.canlet.2005.10.016,   PubMed: 16300879,   Elsevier: Scopus)
3. Piyawan Bunpo, Keiko Kataoka, Hideki Arimochi, Haruyuki Nakayama, Tomomi Kuwahara, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells,
The Journal of Medical Investigation : JMI, Vol.52, No.1,2, 65-73, 2005.
(徳島大学機関リポジトリ: 110758,   DOI: 10.2152/jmi.52.65,   PubMed: 15751275,   CiNii: 1390282679221384192)
4. Piyawan Bunpo, Keiko Kataoka, Hideki Arimochi, Haruyuki Nakayama, Tomomi Kuwahara, Yoshimi Bando, Keisuke Izumi, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
Inhibitory effects of Centella asiatica on azoxymethane-induced aberrant crypt focus formation and carcinogenesis in the intestines of F344 rats,
Food and Chemical Toxicology, Vol.42, No.12, 1987-1997, 2004.
(DOI: 10.1016/j.fct.2004.06.022,   PubMed: 15500935)
5. Naruhiko Sawada, Keiko Kataoka, Kazuya Kondo, Hideki Arimochi, H Fujino, Y Takahashi, Takanori Miyoshi, Tomomi Kuwahara, Y Monden and Yoshinari Ohnishi :
Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice,
British Journal of Cancer, Vol.90, No.8, 1672-1678, 2004.
(DOI: 10.1038/sj.bjc.6601746,   PubMed: 15083202)
6. Mari Hagiwara, Keiko Kataoka, Hideki Arimochi, Tomomi Kuwahara and Yoshinari Ohnishi :
Role of unbalanced growth of Gram-negative bacteria in ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug,
The Journal of Medical Investigation : JMI, Vol.51, No.1,2, 43-51, 2004.
(徳島大学機関リポジトリ: 110713,   DOI: 10.2152/jmi.51.43,   PubMed: 15000255)
7. Hirofumi Shibata, Chikako Shirakata, Hiromi Kawasaki, Youichi Sato, Tomomi Kuwahara, Yoshinari Ohnishi, Naokatu Arakaki and Tomihiko Higuti :
Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically.,
Biological & Pharmaceutical Bulletin, Vol.26, No.10, 1478-1483, 2003.
(DOI: 10.1248/bpb.26.1478,   PubMed: 14519958,   CiNii: 1390282679604409856)
8. Toshiaki Itoh, Tomomi Kuwahara, Takayoshi Suzuki, Makoto Hayashi and Yoshinari Ohnishi :
Regional mutagenicity of heterocyclic amines in the intestine: mutation analysis of the cII gene in lambda/lacZ transgenic mice,
Mutation Research, Vol.539, No.1-2, 99-108, 2003.
(DOI: 10.1016/S1383-5718(03)00134-7,   PubMed: 12948818)
9. Kyoji Morita, Hideki Arimochi and Yoshinari Ohnishi :
In vitro cytotoxicity of 4-methylcatechol in murine tumor cells: Induction of apoptotic cell death by extracellular pro-oxidant action,
The Journal of Pharmacology and Experimental Therapeutics, Vol.306, No.1, 317-323, 2003.
(DOI: 10.1124/jpet.103.050351,   PubMed: 12676882)
10. Shuusuke Nakanishi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi :
Effects of high amylose maize starch and Clostridium butyricum on metabolism in colonic microbiota and formation of azoxymethane-induced aberrant crypt foci in the rat colon,
Microbiology and Immunology, Vol.47, No.12, 951-958, 2003.
(PubMed: 14695445)
11. Yaowarate Intiyot, Takemi Kinouchi, Keiko Kataoka, Hideki Arimochi, Tomomi Kuwahara, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats,
The Journal of Medical Investigation : JMI, Vol.49, No.1,2, 25-34, 2002.
(徳島大学機関リポジトリ: 110631,   PubMed: 11901756)
12. T Koizumi, K Murakami, Tomomi Kuwahara and Yoshinari Ohnishi :
Preparation of Low-Phosphorus Cow's Milk,
Journal of Food Science, Vol.67, No.6, 2046, 2002.
(DOI: 10.1111/j.1365-2621.2002.tb09498.x,   Elsevier: Scopus)
13. Minoru Higashimoto, Yoshinobu Akada, Masao Sato, Yoshihide Yamada, Tomomi Kuwahara and Yoshinari Ohnishi :
Inhibitory effects of herbal teas and herb extracts on the mutagenicity of 1-methy1-1, 2, 3, 4-tetrahydro-β-carboline-3-carboxylic acid upon treatment with nitrite in the presence of ethanol,
Environmental Mutagen Research, Vol.23, No.1, 1-7, 2001.
14. Tomomi Kuwahara, Haruyuki Nakayama, Tsuyosi Miki, Keiko Kataoka, Hideki Arimochi and Yoshinari Ohnishi :
PCR-dot blot hybridization based on the neuraminidase-encoding gene is useful for detection of Bacteroides fragilis,
The Journal of Medical Investigation : JMI, Vol.48, No.1,2, 60-65, 2001.
(徳島大学機関リポジトリ: 29050,   PubMed: 11286018)
15. Teera Chewonarin, Tomomi Kuwahara, Hideki Arimochi, Keiko Kataoka, Haruyuki Nakayama, Dae-Yeul Yu, Hiroyuki Tsuda, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
Expression of Human Lactoferrin in Bacteroides uniformis and its Effect on Azoxymethane-induced Aberrant Crypt Focus Formation in the Rat Colon,
Anaerobe, Vol.7, No.5, 247-253, 2001.
(DOI: 10.1006/anae.2001.0391,   Elsevier: Scopus)
16. Tomomi Kuwahara, Izumi Norimatsu, Haruyuki Nakayama, Shigeru Akimoto, Keiko Kataoka, Hideki Arimochi and Yoshinari Ohnishi :
Genetic variation in 16S-23S rDNA internal transcribed spacer regions and the possible use of this genetic variation for molecular diagnosis of Bacteroides species,
Microbiology and Immunology, Vol.45, No.3, 191-199, 2001.
(PubMed: 11345528,   Elsevier: Scopus)
17. M Higashimoto, Y Akada, M Sato, Takemi Kinouchi, Tomomi Kuwahara and Yoshinari Ohnishi :
Inhibitory effects of tea extracts on the mutagenicity of 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid on treatment with nitrite in the presence of ethanol,
Food and Chemical Toxicology, Vol.38, No.1, 7-13, 2000.
(DOI: 10.1016/S0278-6915(99)00121-0,   PubMed: 10685009)
18. Hideki Arimochi, Keiko Kataoka, Tomomi Kuwahara, Haruyuki Nakayama, Norihiko Misawa and Yoshinari Ohnishi :
Effects of β-Glucuronidase-Deficient and Lycopene-Producing Escherichia coli Strains on Formation of Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon,
Biochemical and Biophysical Research Communications, Vol.262, No.2, 322-327, 1999.
19. Teera Chewonarin, Takemi Kinouchi, Keiko Kataoka, Hideki Arimochi, Tomomi Kuwahara, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
Effects of roselle (Hibiscus sabdariffa Linn.), a Thai medicinal plant, on the mutagenicity of various known mutagens in Salmonella typhimurium and on formation of aberrant crypt foci induced by the colon carcinogens azoxymethane and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in F344 rats,
Food and Chemical Toxicology, Vol.37, No.6, 591-601, 1999.
(DOI: 10.1016/S0278-6915(99)00041-1,   PubMed: 10478827)
20. Ruo Shan Bing, Takemi Kinouchi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi :
Protective effects of a culture supernatant of Lactobacillus acidophilus and antioxidants on ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug,
Microbiology and Immunology, Vol.42, No.11, 745-753, 1998.
21. Takemi Kinouchi, Keiko Kataoka, Ruo Shan Bing, Haruyuki Nakayama, Motoo Uejima, Kazuyuki Shimono, Tomomi Kuwahara, Shigeru Akimoto, Isao Hiraoka and Yoshinari Ohnishi :
Culture supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis repress ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug by suppressing unbalanced growth of aerobic bacteria and lipid peroxidation,
Microbiology and Immunology, Vol.42, No.5, 347-355, 1998.
22. Hideki Arimochi, Takemi Kinouchi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi :
Activation of 1-nitropyrene by nitroreductase increases the DNA adduct level and mutagenicity,
The Journal of Medical Investigation : JMI, Vol.44, No.3-4, 193-198, 1997.
(徳島大学機関リポジトリ: 110666,   PubMed: 9597808)
23. Hideki Arimochi, Takemi Kinouchi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi :
Effect of Intestinal Bacteria on Formation of Azoxymethane-Induced Aberrant Crypt Foci in the Rat Colon,
Biochemical and Biophysical Research Communications, Vol.238, No.3, 753-757, 1997.
(DOI: 10.1006/bbrc.1997.7384,   PubMed: 9325162)
24. Ratchada Suaeyun, Takemi Kinouchi, Hideki Arimochi, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
Inhibitory effects of lemon grass (Cymbopogon citratus Stapf) on formation of azoxymethane-induced DNA adducts and aberrant crypt foci in the rat colon,
Carcinogenesis, Vol.18, No.5, 949-955, 1997.
25. Haruyuki Nakayama, Takemi Kinouchi, Keiko Kataoka, Shigeru Akimoto, Yoshiko Matsuda and Yoshinari Ohnishi :
Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil.,
Pharmacogenetics, Vol.7, No.1, 35-43, 1997.
(PubMed: 9110360,   CiNii: 1570854175671010176)
26. Kazuya Kondo, Atsushi Umemoto, Shigeru Akimoto, Tadashi Uyama, Kenshi Hayashi, Yoshinari Ohnishi and Yasumasa Monden :
Mutations in the P53 tumour suppressor gene in primary lung cancer in Japan.,
Biochemical and Biophysical Research Communications, Vol.183, No.3, 1139-1146, 1992.
(PubMed: 1348931)

学術論文(紀要・その他):

1. 大西 克成, 片岡 佳子, 有持 秀喜, 桑原 知巳, 中山 治之, 萩原 真理 :
腸内菌の機能,
日本臨床腸内微生物学会誌, Vol.6, No.1, 5-9, 2004年.

総説・解説:

1. 有持 秀喜, 木内 武美, 片岡 佳子, 桑原 知巳, 大西 克成 :
大腸前癌病変発生に対する腸内菌の影響,
消化器癌の発生と進展, Vol.10, 29-30, 1998年.

国際会議:

1. Yoshinari Ohnishi, Keiko Kataoka, Hideki Arimochi, Shuusuke Nakanishi, Piyawan Bunpo, Naruhiko Sawada, Haruyuki Nakayama, Tomomi Kuwahara and Usanee Vinitketkumnuen :
PREVENTION OF COLORECTAL CARCINOGENESIS IN RATS,
The 3rd International Congres of Asian Society of Toxicology, Bangkok, Feb. 2004.
2. Punya Temcharoen, Pattaraporn Khongboon, Lakana Himakoun, Chaivat Toskulkao, Hideki Arimochi and Yoshinari Ohnishi :
Inhibitory effect of piperine on 1,2-dimethyl hydrazineinduced formation of aberrant crypt foci in the rat colon,
8th International Conference on Environmental Mutagens, Vol.P7-35, Shizuoka, Oct. 2001.
3. Hideki Arimochi, Teera Chewonarin, Keiko Kataoka, Tomomi Kuwahara, Haruyuki Nakayama, Yeul-Dae Yu, Hiroyuki Tsuda, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
Effects of cultures of β-glucuronidase-deficient Escherichia coli and lactoferrin-producing Bacteroides uniforinis on formation of azoxymethane-Induced aberrant crypt foci in the rat colon,
ICIB2001, Tokyo, Jul. 2001.
4. Hideki Arimochi, Teera Chewonarin, Keiko Kataoka, Tomomi Kuwahara, Haruyuki Nakayama, Norihiko Misawa, Hiroyuki Tsuda, Dae-Yeul Yu, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
Prevention of colon carcinogen-induced aberrant crypt focus formation by functional intestinal bacteria.,
Takeo Wada Cancer Research Symposium, Chiang Mai, Nov. 2000.
5. Hideki Arimochi, Keiko Kataoka, Tomomi Kuwahara and Yoshinari Ohnishi :
Effect of Intestinal bacteria and lycopene-producing Escherichia coli on the formation of preneoplastic colonic lesions induced by azoxymethana in rat,
AACR Annual Meeting, Philadelphia, Apr. 1999.
6. Yoshinari Ohnishi, Keiko Kataoka, Takemi Kinouchi, Hideki Arimochi, Tomomi Kuwahara, Teera Chewonarin, Yaowarate Intiyot and Usanee Vinitketkumnuen :
EFFECTS OF MEDICINAL PLANTS AND ANTIBIOTICS ON FORMATION OF 2-AMINO-1-METHYL-6-PHENYLIMIDAZO(4,5-b) PYRIDINE(PhIP)-INDUCED ABERRANT CRYPT FOCI IN THE RAT COLON.,
The 7th International Conference on Carcinogenic/Mutagenic N-Substituted Aryl Compounds First Circular, Nagoya, Nov. 1998.
7. Tomomi Kuwahara, Shigeru Akimoto, Izumi Norimatsu, Syed Mohammed Shaheduzzaman, Haruyuki Nakayama, Hideki Arimochi, Keiko Kataoka and Yoshinari Ohnishi :
DNA diagnosis of the genus Bacteroides and related species.,
第4回日韓国際微生物学シンポジウム, Tokushima, Oct. 1998.
8. Yoshinari Ohnishi, Keiko Kataoka, Takemi Kinouchi, Hideki Arimochi, R Yoshida, Tomomi Kuwahara, Ratchads Suaeyun, Teera Chewonarin, Yaowarate Intiyot and Usanee Vinitketkumnuen :
Inhibitory effects of medicinal plants and their components on bacterial mutagenesis and the initiation stage of colon carcinogenesis,
17th International Cancer Congress, Rio de Janeiro, Aug. 1998.
9. Takemi Kinouchi, Ratchada Suaeyun, Teera Chewonarin, Yaowarate Intiyot, Hideki Arimochi, Keiko Kataoka, Shigeru Akimoto, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
CHEMOPREVENTIVE EFFECTS OF THAI MEDICINAL PLANTS ON FPRMATION OF AZOXYMETHANE-INDUCED DNA ADDUCTS AND ABERRANT CRYPT FOCI IN THE RAT COLON,
7th Iat Can Env Mutagenesi, Zuerich, Sep. 1997.
10. Ratchada Suaeyun, Takemi Kinouchi, Hideki Arimochi, Usanee Vinitketkumnuen and Yoshinari Ohnishi :
Inhibitory effects of lemon grass on formation of azoxymethane-induced DNA adducts and aberrant crypt foci in the rat colon,
88th Annual Meeting of the American Association for Canser Reseaved, San Diego, Apr. 1997.