Tokushima University / Educator and Researcher Directory --- Saito, Ken

Personal Web Page

https://researchmap.jp/read0037887 (researchmap)

Field of Study

○	Cardiovascular Medicine

Subject of Study

○	ホルター心電図による心拍変動解析を利用した各種病態時の自律神経異常の検討, 各種疾患における心拍ゆらぎ(1/Fゆらぎ)解析の研究 (ホルター心電図, 心拍スペクトル, 自律神経機能, 1/Fゆらぎ)

Book / Paper

Book:

1.	Ken Saito : Ambulatory electrocardiography, 医学出版社, Tokyo, Oct. 2015. (Keyword) Ambulatory ECG / Indication / Evaluation of arrhythmia / HRV analysis
2.	Ken Saito : 徹底解説!心電図, --- Electrolyte imbalance ---, 医学出版社, Tokyo, Oct. 2015. (Keyword) Electrolyte imbalance / electrocardiogram / arrhythmia / Sudden death
3.	森博愛, Ichiro Shimizu, 長瀬教夫, Masahiro Nomura, Akiyoshi Nishikado, 井内新, Susumu Ito, Hirohito Honda, Seisuke Okamura, Tsuneo Ninomiya, Ken Saito, 田村禎通, Yutaka Nakaya, Naoki Muguruma, Toshiaki Hashimoto and 高橋昌江 : メディカルスタッフのための内科学(第4版), 医学出版社, Tokyo, Mar. 2013.
4.	Ken Saito : Ambulatory ECG monitoring in clinical practice, MEDICAL VIEW CO., LTD., Tokyo, Mar. 2013.
5.	Ken Saito and Takeshi Soeki : 循環器症候群(第2版)Ⅰ, NIPPONRINSHOSHA Co.,Ltd., Osaka, Aug. 2007.
6.	Ken Saito, Kuniaki Otsuka, Yutaka Kubo and Shougo Murakami : Ambulatory ECG, 医学出版社, Tokyo, Mar. 2005.
7.	森博愛, Ichiro Shimizu, 長瀬教夫, Masahiro Nomura, Akiyoshi Nishikado, 井内新, Susumu Ito, Hirohito Honda, Seisuke Okamura, 近森一正, Ken Saito, 白神皞, Yutaka Nakaya, Toshiya Okahisa and 橋本俊顕 : コメディカルのための内科学(第2版), 医学出版社, Tokyo, Apr. 2001.
8.	加藤寛正, Masahiro Nomura, 越智由恵, Ken Saito, Naoki Muguruma, Toshiya Okahisa, Hiroshi Shibata, Seisuke Okamura, Hirohito Honda, Ichiro Shimizu and Susumu Ito : 慢性消化性潰瘍におけるHelivobactor pylori除菌前後の自律神経活動の検討, 四国消化性潰瘍研究会, 2001.
9.	Yutaka Nakaya, M Yukinaka, Masahiro Nomura, F Kishi and Ken Saito : Analysis of elevtromotive force by magnetocardiogram Is the origin of initial QRS force (septal vector) of electrocardiogram intraventricular septum?, Springer-Verlag, 2000.
10.	Masahiro Nomura, 名田智美, 近藤幸, 由岐中道子, Toshiya Okahisa, Hiroshi Shibata, Seisuke Okamura, Hirohito Honda, Ichiro Shimizu, Ken Saito, Susumu Ito and Yutaka Nakaya : 慢性消化性潰瘍形成において自律神経機能異常は必要条件か?心拍変動1/fゆらぎおよびHelicobactor pyloriとの関連性, 四国消化性潰瘍研究会, Matsuyama, 1999.
11.	M Yukinaka, Masahiro Nomura, T Nada, Y Kondo, Ken Saito, Susumu Ito and Yutaka Nakaya : QTc dispersion using magnetocardiogram: analysis in patients with myocardial infarction, Tohoku University press., 1999.
12.	Masahiro Nomura, Y Kondo, T Nada, M Yukinaka, Ken Saito, Susumu Ito and Yutaka Nakaya : Biomagnetic measurement of small intestinal electrical activity by 64-channel magnetographic imaging, Tohoku University press., 1999.
13.	Masahiro Nomura, Yutaka Nakaya, Fumiko Kishi, Michiko Yukinaka, Ken Saito, Hiroshi Shibata and Susumu Ito : Heart rate variability during painful medical procedures (percutaneous ethanol injection therapy), World Scientific Publishing, 1997.
14.	Tetsuya Saijyo, Masahiro Nomura, Ken Saito, Seisuke Okamura, Hirohito Honda, Ichiro Shimizu, Susumu Ito, 白石吉彦, 山本浩史 and 折野俊介 : 消化性潰瘍発生に及ぼす自律神経の検討, ホワイトPR, 1996.
15.	Masahiro Nomura, Ken Saito, Yutaka Nakaya and Susumu Ito : 循環器症候群·領域別症候群シリーズ No.12 複数短形性心室頻拍, NIPPONRINSHOSHA Co.,Ltd., Osaka, 1996.
16.	岸史子, Masahiro Nomura, Ken Saito, Yutaka Nakaya and Susumu Ito : 循環器症候群·領域別症候群シリーズ No.12 倒錯型心室頻拍, NIPPONRINSHOSHA Co.,Ltd., Osaka, 1996.
17.	岸史子, Masahiro Nomura, Ken Saito, Yutaka Nakaya and Susumu Ito : 循環器症候群·領域別症候群シリーズ No.12 単形性心室頻拍, NIPPONRINSHOSHA Co.,Ltd., Osaka, 1996.
18.	Ken Saito, 岸史子, Masahiro Nomura and Yutaka Nakaya : 循環器症候群·領域別症候群シリーズ No.12 多形性心室頻拍, NIPPONRINSHOSHA Co.,Ltd., Osaka, 1996.
19.	Ken Saito, 岸史子, Masahiro Nomura and Yutaka Nakaya : 循環器症候群·領域別症候群シリーズ No.12 特発性心室細動, NIPPONRINSHOSHA Co.,Ltd., Osaka, 1996.
20.	Masahiro Nomura, 森博愛, Ken Saito and Susumu Ito : 循環器症候群Ⅰ 領域別症候群シリーズ No.12 Brugada症候群, NIPPONRINSHOSHA Co.,Ltd., Osaka, 1996.
21.	西條哲也, Toshiya Okahisa, Seisuke Okamura, Hiroshi Shibata, Hirohito Honda, Ichiro Shimizu, 折野俊介, Masahiro Nomura, Ken Saito and Susumu Ito : 高血圧合併消化性潰瘍の自律神経機能の検討, ホワイトPR, 1995.
22.	Yutaka Nakaya, Masahiro Nomura, Ken Saito, F Kishi, Hirokazu Miyoshi and Akiyoshi Nishikado : Comparative studies of magnetocardiographic and electrocardiographic mappings for the localization of accessory pathway in WPW syndrome, IOS Press, 1995.
23.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi, Hirokazu Miyoshi, Susumu Ito, Masao Wada, Satoshi Fujita, Tsutomu Takae and Itsuro Tamura : Atrial excitation onto the MRI using magnetocardiogram., IOS Press, 1995.
24.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, F Kishi, H Miyoshi, Susumu Ito, M Wada, S Fujita, T Takae and I Tamura : Localization of the focus in ventricular tachycardia by magnetocardiogram, IOS Press, 1995.
25.	森博愛, 白神皞, 近藤一正, Yutaka Nakaya, Ken Saito and Ichiro Shimizu : コメディカルのための内科学, 医学出版社, Tokyo, May 1994.
26.	Yutaka Nakaya, Kazuhiro Mori, H Miyoshi, F Kishi, Ken Saito and Masahiro Nomura : Cyclic AMP-mediated nitric oxide production by vasoactive substances, Yubunsha Publishing, 1994.
27.	森博愛, 小塚隆弘, 松尾裕英 and Ken Saito : 心臓病のイメージ診断, Medical-Aoi Publications,Inc, Tokyo, Nov. 1992.
28.	Toshihiro Aono, Ken Saito and 他多数 : PERINATAL CARE, Medicus SHUPPAN, Osaka, Aug. 1992.
29.	Ken Saito, 森博愛, Yutaka Nakaya, 日浅芳一 and 坂東重信 : 心電図の基礎と臨床, IGAKU-SHOIN Ltd.Tokyo,Japan, Tokyo, Oct. 1990.
30.	前田如矢, Ken Saito, 仁木敏晴 and 他22名 : 日経メディクイズ, 日経メディカル, Tokyo, Jul. 1989.
31.	板東重信, 森博愛, Ken Saito and 他3名 : 症例から学ぶ心電図活用法, KANEHARA & CO., LTD., Tokyo, Feb. 1986.
32.	Ken Saito, 森博愛, 田村禎通, 岡島光治, 早川弘一, 矢永尚士 and 他 : 長時間心電図の臨床, NANZANDO Co.,Ltd., Tokyo, Apr. 1985.
33.	阿部正和, 尾前照雄, 河合忠一, 越川昭三, Ken Saito, 森博愛 and 他23名 : 内科MOOK 電解質異常, KANEHARA & CO., LTD., Tokyo, Feb. 1985.
34.	Hiroyoshi Mori, Toshiharu Niki, Yoshiyuki Tamura, Yutaka Nakaya, Ken Saito and 他25名 : 最新循環器病学, KANEHARA & CO., LTD., Tokyo, Oct. 1983.
35.	Ken Saito, Yutaka Nakaya, Hiroyoshi Mori, Yoshiyuki Tamura and 他10名 : 虚血症心疾患, 医学出版社, Tokyo, Jul. 1982.

Academic Paper (Judged Full Paper):

1.	Kyoko Osaka, Hiroko Sugimoto, Tetsuya Tanioka, Yuko Yasuhara, Rozzano De Castro Locsin, Yueren Zhao, Kikuko Okuda and Ken Saito : Characteristics of a Transactive Phenomenon in Relationships among Older Adults with Dementia, Nurses as Intermediaries, and Communication Robot, Intelligent Control and Automation, Vol.8, 111-125, 2017. (Keyword) Transactive Phenomenon / Nursing as Intermediaries / Older Adults with Dementia / Communication Robot (Link to Publication Site) ● Publication site (DOI): 10.4236/ica.2017.82009 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.4236/ica.2017.82009 (DOI: 10.4236/ica.2017.82009)
2.	Hiroko Sugimoto, Yuko Yasuhara, Tetsuya Tanioka, Yoshiko Gogi, Kenji Mori, Shoko Fuji and Ken Saito : Relationship between sleep-wake rhythms and autonomic nerve activities of elementary school children through Actigraphy, Shikoku Acta Medica, Vol.72, No.1,2, 43-52, 2016. (Summary) The purpose of this study was to clarify the relationship between sleep-wake rhythms and autonomic nerve activities using actigraphy and heart rate variability(HRV)analysis. Subjects were comprised of six children who were in the fourth to sixth grade levels of elementary school(four boys and two girls). The study was conducted between January and December 2015. The data collection procedure was performed following the Private Information Protection Law, with approval from Tokushima University Hospital Ethics Board(approval number 2021). These subjects were evaluated in an Attentive-Care-Needed stress state based on the PSI(Public Health Research Foundation Type Stress Inventory)and PSQI-J(Pittsburgh Sleep Quality Index, Japanese Version). In analyzing their sleep-wake rhythms, autonomic nervous activities were determined using an actigraph and HRV through RR interval sequence electrocardiography. The results of actigraph data of sleep efficiency in Subject Number 6 was low(76.47%). Regardless, the subject experienced subjective sleep satisfaction. However, Subject Number 2, insisted that she could not easily wake up in the morning because of being sleepy. Low Frequency(LF)/High Frequency(HF)data indicated sympathetic nervous activity showing that all subjects had significantlyhigher LF/HF value during wakefulness than when asleep. HF data indicated parasympatheticactivity of five out of the six children showing significantly higher value during sleep than when awake. Subject number 3 expressed that he was sleepy and could not get up in the morning,and also had trouble going to and maintaining sleep. However, this subject's results of the PSQI-Jindicated that he had no problem expressing subjective sleep satisfaction. Furthermore, in the actigraph and HRV analysis, findings showed that subjects had good sleeping patterns. These findings strongly signify the importance of determining the sleep-wake rhythms of school children based on data from subjective and physiological evaluation methods. (Keyword) Primary school children / Sleep-wake rhythm / Autonomic nervous activity / Sleep Quality / Stress (Tokushima University Institutional Repository) ● Metadata: 110379 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1050845762395246208 (Tokushima University Institutional Repository: 110379, CiNii: 1050845762395246208)
3.	Shoko Fuji, Tetsuya Tanioka, Yuko Yasuhara, Miki Satoh, Ken Saito, Marguerite J. Purnell, Rozzano De Castro Locsin and Toshiyuki Yasui : Characteristic Autonomic Nervous Activity of Institutionalized Elders with Dementia, Open Journal of Psychiatry, Vol.6, No.1, 34-49, 2015. (Keyword) Elderly Dementia / Actigraph / Heart Rate VariabilityAutonomic Nervous Activity / Behavior Observation / Care Activities (Tokushima University Institutional Repository) ● Metadata: 109699 (Link to Publication Site) ● Publication site (DOI): 10.4236/ojpsych.2016.61004 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.4236/ojpsych.2016.61004 (Tokushima University Institutional Repository: 109699, DOI: 10.4236/ojpsych.2016.61004)
4.	Shoko Fuji, Miki Satoh, Yuko Yasuhara, Tetsuya Tanioka, Rozzano De Castro Locsin and Ken Saito : The Effect of Intentional Communication, Recreation, and Rehabilitation on the Autonomic Nervous Activity of Elderly Persons with Dementia : A Case Study, Journal of Nursing and Health Sciences, Vol.9, 82-89, 2015. (Keyword) dementia / elderly / Autonomic Nervous Activity / Intentional Communication / l/f fluctuation
5.	Ken Saito, S Takeda, Y Saito, M Kawamura, Y Yoshikawa, H Yano and Masataka Sata : Electrocardiographic and chronobiological features of paroxysmal AV block recorded by ambulatory electrocardiography., The Journal of Medical Investigation : JMI, Vol.61, No.3, 4, 380-387, 2014. (Summary) The goal of this study was to investigate the electrocardiographic and chronobio-logical features of paroxysmal atrioventricular (AV) block (PAVB) using data from ambulatory electrocardiography (AECG). The study population consisted of five men and six women aged from 47 to 82 years of age. Main presenting symptoms were pre-syncope in five patients (45.5%) and syncope in three patients (27.3%). Organic cardiovascular diseases were seen in eight patients (72.7%), and AV conduction disturbances were seen in six patients (54.5%), such as right bundle branch block, first to second degree AV block on standard 12-lead electrocardiography. Incidence of PAVB events were 1-329 (37.9 ± 98.0) episodes/patient/day, and the maximum pause during Holter recordings was 3.3-12.4 (6.39 ± 3.09) seconds. This maximum pause caused by intrinsic AV block was longer than that of vagally mediated AV block (8.4 ± 3.2 sec vs 4.7 ± 1.0 sec, p<0.05). In chronobiological analysis, episodes of PAVB exhibited a circadian rhythm characterized by a peak between 2:00 am and 4:00 am and a trough between 0:00 pm and 2:00 pm. AECG is a useful tool to detect the maximum pause occurring during sleep and provides critical data necessary to prevent the sudden cardiac death caused by PAVB. (Keyword) paraxysmal AV block / ambulatory electrocardiography / circadian rhythm / syncope / right bundle branch block (Tokushima University Institutional Repository) ● Metadata: 109588 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.61.380 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264058 ● Summary page in Scopus @ Elsevier: 2-s2.0-84907500921 (Tokushima University Institutional Repository: 109588, DOI: 10.2152/jmi.61.380, PubMed: 25264058, Elsevier: Scopus)
6.	Ken Saito, Hiya Akiko, Uemura Yumi and Furuta Miwa : Clinical training stress and autonomic nervous function in female medical technology students: analysis of heart rate variability and 1/fluctuation, The Journal of Medical Investigation : JMI, Vol.55, No.3,4, 227-230, 2008. (Summary) To evaluate the level of stress induced by clinical training, ambulatory electrocardiograms from 12 healthy female medical technology students were recorded and the spectral components of heart rate variability (HRV) were analyzed as an index of autonomic nervous function. The HF power reflecting parasympathetic tone was significantly decreased at awakening, compared with that before clinical training (p<0.01). The LF/HF ratio reflecting sympathetic activity also significantly increased during, compared with before clinical training (p<0.01). The slope of the spectral density also changed before and during the clinical training from -1.20+/-0.04 to -1.09+/-0.03 (p<0.05). The 1/f fluctuation of HRV appeared comfortable, and tension was apparently adequate while undergoing clinical training. None of these HRV indices statistically changed while asleep. Thus, the students perceived the stress as a comfortable level of tension and analyzing spectral components and 1/f fluctuation of HRV might be a useful method for evaluating study stress. (Keyword) Adult / analysis of variance / Autonomic Nervous System / Electrocardiography / female / Heart Rate / Humans / Medical Laboratory Science / Stress, Physiological / Young Adult (Tokushima University Institutional Repository) ● Metadata: 110863 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.55.227 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18797135 ● Search Scopus @ Elsevier (PMID): 18797135 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.55.227 (Tokushima University Institutional Repository: 110863, DOI: 10.2152/jmi.55.227, PubMed: 18797135)
7.	Hiroshi Fukuno, Katsuyoshi Tamaki, Mari Urata, Nao Kohno, Ichiro Shimizu, Masahiro Nomura, Susumu Ito and Ken Saito : Influence of an artificial pleural effusion technique on cardio-pulmonary function and autonomic activity, The Journal of Medical Investigation : JMI, Vol.54, No.1,2, 48-53, 2007. (Summary) Percutaneous treatment of hepatocellular carcinoma (HCC) located directly under the diaphragm is problematic because ultrasonic imaging is difficult, and the lung may be injured during the procedure. It has been reported that an infusion of 5% glucose solution into the thoracic cavity enables percutaneous treatment in such cases. However, the safety aspects of this have not been investigated. In this study, variations in heart rate and changes in circulatory and respiratory dynamics were examined during the infusion of artificial pleural effusion directly under the diaphragm in patients with HCC. The subjects were 13 patients with an HCC directly under the diaphragm. About 500 ml of a 5% glucose solution was infused into the thoracic cavity, and mean blood pressure, heart rate, and oxygen saturation were measured. Holter electrocardiography was simultaneously recorded to evaluate autonomic nerve function. To analyze variations in heart rate, the low-frequency waves (LF: 0.04-0.15 Hz), high-frequency waves (HF: 0.15-0.40 Hz, an index of parasympathetic nerve activity), and the LF/HF ratio (index of sympathetic nerve activity) were examined. The above parameters were measured before, during (when infusion of the half the planned volume was complete), and after infusion were compared. No significant changes in the mean blood pressure or heart rate were found. Oxygen saturation was significantly decreased during and after the infusion. The HF value was slightly higher after infusion and the LF value was significantly increased during infusion. The LF/HF ratio was significantly increased during infusion, and this increase persisted after infusion. The infusion of artificial pleural effusion had no effect on circulatory dynamics, but transiently affected respiratory functions. It was also revealed that infusion stimulated the parasympathetic nerves. (Keyword) Adult / Aged / Autonomic Nervous System / blood pressure / Carcinoma, Hepatocellular / Catheter Ablation / female / Heart Rate / Humans / Liver Neoplasms / male / Middle Aged / Pleural Effusion / Oxygen / respiration (Tokushima University Institutional Repository) ● Metadata: 111494 (Link to Publication Site) ● Publication site (DOI): 10.2152/jmi.54.48 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17380014 ● Search Scopus @ Elsevier (PMID): 17380014 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.54.48 (Tokushima University Institutional Repository: 111494, DOI: 10.2152/jmi.54.48, PubMed: 17380014)
8.	中村仁志夫, 佐藤剛, 松尾淳司, 野坂大喜, 渡邊信, 岡本基, Ken Saito, 堀尾勝, 梅村創, 田中淳之, 佐藤健次, 真栄平房子, 大高徹也, 岩渕光哉, 浦山修 and 高宮脩 : An Investigation on the Affinity between the Questions in the National Examination for Medical Technologist and Educated Contents in the Course of Laboratory Medicine : Nine Years History of the Committee Groping Appropriate Questions, The Official Journal of Japanese Society of Laboratory Medicine, Vol.55, No.1, 24-34, 2007. (Summary) In order to evaluate the each question in the National Examination for Medical Technologist by comparison with the educated level in the course of laboratory medicine and the practical level of medical technologists, the investigation has been carried out by our committee established in the National University Association for Education of Laboratory Medicine during 9 years since 1997. The committee has asked each school of the 20 members of the Association to pick up good and/or inappropriate questions with the reasons why they are classified as good or improper ones. Some questions were considered as good ones by a large number of schools, while the others were considered improper. The reasons for the judgment have been sometimes very controversial and opinions uncommonly run counter to each other. It is suggested that a good question may become to be improper when the questionnaire is carelessly arranged even if the concept of the question is initially well considered. It is presumed that the annual reports of our committee may have played a role to gain common recognition that the numbers of the inappropriate questions have been decreasing in the recent National Examination for Medical Technologist. (Keyword) National Examination for Medical Technologist / education in laboratory medicine / good questions / inappropriate questions / investigation on the questionnaire / 良問 / inappropriate questions / 不適切問題 / investigation on the questionnaire / アンケートに基づく検討 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17319487 ● CiNii @ National Institute of Informatics (CRID): 1520290884525708672 ● Search Scopus @ Elsevier (PMID): 17319487 (PubMed: 17319487, CiNii: 1520290884525708672)
9.	Yukie Iwasa, Kimiko Nakayasu, Masahiro Nomura, Yutaka Nakaya, Ken Saito and Susumu Ito : The relationship between autonomic nervous activity and physical activity in children, Pediatrics International, Vol.47, No.4, 361-371, 2005. (Summary) There have been few studies that have reported on heart rate variability and the development of autonomic nervous function in children. This study investigated the relationship between heart rate variabilities at night and physical activity in children. The study subjects were 29 children, including 17 boys and 12 girls. The daily activity product and heart rate variabilities during sleep at night (00.00-05.00 hours) were measured and several aspects of these parameters were analyzed. In one child (an 8-year-old girl), heart rate variability and the physical activity product were measured for 12 days. There was a negative correlation between the mean R-R interval and the duration (min) of heavy exercise per day (r = -0.39, P < 0.05). In the 8-year-old girl, from whom data was obtained for 12 days, the duration of heavy exercise per day was negatively correlated with the mean R-R interval (r = -0.63, P < 0.05), the number of changes in successive R-R intervals greater than 50 msec (RR50) (r = -0.74, P < 0.01), and the high frequency (HF) component (r = -0.66, P < 0.05). Furthermore, the daily number of steps was negatively correlated with the mean R-R interval (r = -0.66, P < 0.05), RR50 (r = -0.71, P < 0.05) and the HF component (r = -0.66, P < 0.05). There was a negative correlation between the amounts of energy consumption and the mean R-R interval (r = -0.69, P < 0.05). There was a negative correlation between the amounts of energy consumption and RR50 (r = -0.76, P < 0.01). Moreover, there was also a negative correlation between the amount of energy consumption and the HF component (r = -0.71, P < 0.05). These findings suggested that physical activities increase heart rate during sleep, but reduce parasympathetic nervous activity at night. Because both the HF component and RR50 reduce with growth, the exercise-related inhibition of parasympathetic nervous activity may be a developmental stimulus to reach a balanced autonomic nervous pattern in adults. (Keyword) autonomic nervous / child / heart rate variability / physical activity (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1442-200x.2005.02082.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16091070 ● Search Scopus @ Elsevier (PMID): 16091070 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1442-200x.2005.02082.x (DOI: 10.1111/j.1442-200x.2005.02082.x, PubMed: 16091070)
10.	Masahiro Nomura, Kohzou Uehara, Kenji Harada, Eiko Uemura, Akiko Iga, Tomohito Kawano, Akiyoshi Nishikado, Ken Saito, Yutaka Nakaya and Susumu Ito : Impairment of gastrointestinal motility by nitrate administration: evaluation based on electrogastrographic changes and autonomic nerve activity, Alimentary Pharmacology & Therapeutics, Vol.20, No.s1, 118-124, 2004. (Summary) Nitrates decrease the tone of the lower oesophageal sphincter, and may thus induce gastro-oesophageal reflux. In the present study, we evaluated electrogastrographic changes and heart-rate variability before and after the administration of nitrates. In 15 patients with chest pain treated with nitrates, electrocardiography and percutaneous electrogastrography were performed before and after administration of nitrates. Autonomic nervous system function was evaluated by spectral analysis of heart-rate variability and serial changes in low frequency and high frequency power, and the low frequency/high frequency ratio were compared. Electrogastrograms were analysed by obtaining peak power amplitudes and their dominant frequencies. After the administration of nitrates (isosorbide dinitrate), high frequency power, an index of parasympathetic nervous activity, was significantly decreased, whereas the low frequency/high frequency ratio, an index of sympathetic nervous activity, was significantly increased. The mean peak amplitude of the electrogastrogram significantly increased postprandially both before and after treatment. After isosorbide dinitrate treatment, however, mean peak amplitudes after a meal were significantly lower than those obtained before treatment. The mean dominant frequency of the electrogastrogram did not vary before and after treatment. The present study suggests that nitrates inhibit gastrointestinal motility by decreasing autonomic nervous activity. (Keyword) Aged / Autonomic Nervous System / Chest Pain / Electrocardiography, Ambulatory / Electrophysiology / Gastrointestinal Motility / Heart Rate / Humans / Isosorbide Dinitrate / Nitrates / Nitric Oxide Donors / Postprandial Period / spectrum analysis (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1365-2036.2004.01979.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15298617 ● Search Scopus @ Elsevier (PMID): 15298617 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1365-2036.2004.01979.x (DOI: 10.1111/j.1365-2036.2004.01979.x, PubMed: 15298617)
11.	Jyunji Yamashita, Masahiro Nomura, Kohzou Uehara, Yutaka Nakaya, Eiko Uemura, Akiko Iga, Yuko Sawa, Akiyoshi Nishikado, Ken Saito and Susumu Ito : Influence of sleep apnea on autonomic nervous activity and QT dispersion in patients with essential hypertension and old myocardial infarction, Journal of Electrocardiology, Vol.37, No.1, 31-40, 2004. (Summary) Sleep apnea syndrome (SAS) is an important cardiovascular risk factor in patients with hypertension or myocardial infarction (MI). We evaluated the influence of SAS on autonomic nervous activity and QT dispersion in patients with hypertension or coronary artery disease with old MI. A portable sleep polygraph was attached to 30 healthy volunteers (N group), 30 patients with essential hypertension (HT group), and 30 patients with old myocardial infarction (MI group) to serially record oronasal respiration, tracheal sound, thoracic respiratory movement, and percutaneous arterial oxygen saturation. In addition, a digital Holter ECG was used to examine heart rate variability during nighttime sleep. Heart rate variability was analyzed by obtaining low-frequency (LF) power, high-frequency (HF) power, the LF/HF ratio, and very low-frequency (VLF) power. Dispersion of QT intervals was obtained by CM5 and CM1 leads. VLF and LF powers were significantly higher in the HT-SAS group (hypertensive patients with SAS) than the N and HT-NSAS groups (hypertensive patients without SAS). The HF power was significantly lower in the HT-NSAS group than the N group, but the decrease in HF power in hypertension was not observed in the HT-SAS group. The LF/HF ratio was significantly higher in the HT-NSAS group than the N group, and this value was further increased in the HT-NSAS group. Percutaneous arterial oxygen saturation was decreased, and QT dispersion was significantly increased in the MI group during sleep apnea episodes. More severe autonomic nervous dysfunction and increased QTc dispersion were observed in hypertensive patients with SAS during episodes of apneas and hypopneas compared to those without SAS. These findings suggest that SAS may be associated with the future development of cardiac events. (Keyword) SAS / QT dispersion / autonomic nervous activity / cardiac events (Link to Publication Site) ● Publication site (DOI): 10.1016/j.jelectrocard.2003.10.009 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15132367 ● Search Scopus @ Elsevier (PMID): 15132367 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jelectrocard.2003.10.009 (DOI: 10.1016/j.jelectrocard.2003.10.009, PubMed: 15132367)
12.	林亨, Masahiro Nomura, 鳥巣隆資, 仁木美也子, 安田貢, 鹿児島彰, 井上博之, 高橋義典, 山ノ井昭, 坂下修, 竹内議員, Ken Saito and Susumu Ito : 胃X線検査時における体位変換時の自立神経活動の変動, 日本消化器集団検診学会雑誌, Vol.42, No.1, 25-32, 2004.
13.	Hiroshi Okamoto, Masahiro Nomura, Yutaka Nakaya, Kohzou Uehara, Ken Saito, Masaru Kimura, Kazumasa Chikamori and Susumu Ito : Effects of Epalrestat, an Aldose Reductase Inhibitor, on Diabetic Neuropathy and Gastroparesis, Internal Medicine, Vol.42, No.8, 655-664, 2003. (Summary) Diabetic patients with severe autonomic nervous disorder show delayed gastric emptying accompanied by diabetic gastroparesis, which decreases the electric activity of the stomach associated with gastric motility. It is reported that epalrestat, an aldose reductase inhibitor, is useful for treating diabetic neuropathy. Therefore, we evaluated whether this drug improves the decreased gastric motility in diabetic patients. The present study evaluated the electrogastrograms (EGG) and autonomic nervous activity in 15 healthy volunteers (N group), and in 15 diabetic patients before and after the administration of epalrestat (DM group). Autonomic nervous activity was evaluated by spectral analysis of heart rate variability. The EGGs were recorded before and after oral administration of epalrestat (3 months or more) in the DM group. The dominant frequency of EGG was 3 cycles/min (cpm) in the N group. However, these 3 cpm waves disappeared with bradygastria, and postprandial increases in the peak powers of EGG were not observed in the DM group. Both the amplitude of 3 cpm waves and the postprandial peak powers were significantly increased after the administration of epalrestat. The parameters of autonomic nervous activities (LF power, HF power, and the LF/HF ratio) were significantly lower in the DM group before the administration of epalrestat than in the N group. However, these parameters were improved after the administration of epalrestat. Since gastroparesis is a form of diabetic dysautonomia, complication by gastroparesis may influence blood sugar control and the absorbance of oral antidiabetics. Epalrestat significantly increased the amplitude of 3 cpm waves on EGG and improved the spectral analytical parameters of heart rate variability. These findings suggest that epalrestat is useful for the treatment of diabetic gastroparesis. (Keyword) heart rate variability / electrovcardiogram / autonomic nerves / diabetes mellitus (Link to Publication Site) ● Publication site (DOI): 10.2169/internalmedicine.42.655 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12924487 ● Search Scopus @ Elsevier (PMID): 12924487 ● Search Scopus @ Elsevier (DOI): 10.2169/internalmedicine.42.655 (DOI: 10.2169/internalmedicine.42.655, PubMed: 12924487)
14.	Masahiro Nomura, Yutaka Nakaya, Eiko Uemura, Yuko Sawa, Akiko Iga, N Kageyama, Toru Nakayama, Kanji Kusunoki, Tomohito Kawano, K Katoh, Hiroshi Okamoto, Akiyoshi Nishikado, Ken Saito and Susumu Ito : Effects of Benidipine Hydrochloride on Autonomic Nervous Activity in Hypertensive Patients with High- and Low-salt Diets, Arzneimittel-Forschung, Vol.53, No.5, 314-320, 2003. (Summary) The effects of benidipine hydrochloride (CAS 91559-74-5, Coniel) on autonomic nervous activity in hypertensive patients with high- and low-salt diets were investigated. Six patients having a urinary sodium excretion of 80 mEq/day or less (low salt group) and 6 patients having a urinary sodium excretion of 200 mEq/day or more (high salt group) were orally given benidipine hydrochloride (4 mg). Before and four weeks after the treatment with benidipine, 24-h circadian variation in blood pressure and 24-h Holter electrocardiogram (ECG) were recorded. The low frequency power spectrum of heart rate (LF power; 0.04-0.15 Hz), high frequency power spectrum of heart rate (HF power; 0.15-0.40 Hz), and the ratio of LF to HF (LF/HF) were calculated, and these parameters were averaged every hour in every subject. HF power was significantly lower and LF/HF ratio was significantly higher in the high-salt group than in the low-salt group before the treatment. However, the benidipine treatment significantly increased the HF power in both groups, particularly in the high-salt group, and significantly decreased the LF/HF ratio in both groups. Moreover, there was no significant difference in the antihypertensive effect of benidipine between the high- and low-salt intake groups. These results suggest that benidipine favourably influences blood pressure and autonomic nervous activity in hypertensive patients with a high-salt intake. It is concluded that benidipine may be useful for improving the development of salt-induced hypertension and its accompanying haemodynamic responses. (Keyword) Aged / Autonomic Nervous System / Blood Pressure / Calcium Channel Blockers / Circadian Rhythm / Diet, Sodium-Restricted / Dihydropyridines / Female / Heart Rate / Humans / Hypertension / Male / Middle Aged / Sodium, Dietary (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12854358 ● Search Scopus @ Elsevier (PMID): 12854358 (PubMed: 12854358)
15.	吉田裕子, 佐藤光代, 若松恭子, Ken Saito, 大坪利恵 and 矢野勇人 : 発作性心房細動の発生様式に関する検討ー心房性期外収縮と自律神経機能の関与, Journal of Medical Technology, Vol.46, No.12, 1577-1581, 2002. (Keyword) 発作性心房細動 / 心房性期外収縮 / 自律神経機能 (Link to Publication Site) ● Publication site (DOI): 10.11477/mf.1542905286 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1542905286 (DOI: 10.11477/mf.1542905286)
16.	Yoshie Ochi, Masahiro Nomura, Seisuke Okamura, Mitsuyasu Yano, Ken Saito, Yutaka Nakaya and Susumu Ito : Changes in autonomic nervous activity during endoscopic retrograde cholangiopancreatography:a possible factor in cardiac complications., Journal of Gastroenterology and Hepatology, Vol.17, No.9, 1021-1029, 2002. (Summary) The changes of autonomic nervous activity during endoscopic retrograde cholangiopancreatography (ERCP) are closely related to the development of cardiovascular complications, such as arrhythmias and acute coronary syndrome. In the present study, the correlation between changes in hemodynamics and autonomic nervous activity during ERCP procedures was evaluated by analyzing heart rate variability and blood catecholamine levels. Twenty-three patients who underwent ERCP (ERCP group) and 15 control subjects who were only premedicated (C group) were studied. Ambulant ECG, blood pressure, arterial oxygen saturation, and blood level of catecholamine were measured. Autonomic nervous function was assessed by analyzing the spectral analysis and 1/f fluctuation. The low frequency power (LF power; 0.04-0.15 Hz), high frequency power (HF power; 0.15-0.40 Hz, indicator of parasymapathetic tone), the ratio of LF power to HF power (LF/HF ratio, indicator of sympathetic tone), and 1/f fluctuation (indicator of pleasant mood) were calculated. Blood pressure and heart rate were increased and arterial oxygen saturation was decreased in the ERCP group during the endoscopic procedure. Changes in the parameters of autonomic nervous function (LF power, HF power, LF/HF ratio, and 1/f fluctuation) were significantly greater in the ERCP group than in the C group, especially during cholangiography. Moreover, blood levels of catecholamines were significantly increased during the ERCP procedure. In the C group, however, blood levels of catecholamines did not significantly change except directly after premedication. Autonomic nervous activity varied greatly during cholangiography, demonstrating that ERCP has more than a little influence on the cardiovascular system. The results of the present study indicated that attention should be focused on changes in hemodynamics in patients with cardiovascular complications by monitoring the aforementioned hemodynamic parameters during ERCP. (Keyword) Adult / Aged / Autonomic Nervous System / Blood Gas Monitoring, Transcutaneous / Blood Pressure / Blood Pressure Determination / Catecholamines / Cholangiopancreatography, Endoscopic Retrograde / Electrocardiography, Ambulatory / Female / Heart Diseases / Heart Rate / Humans / Male / Middle Aged / Risk Factors (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1440-1746.2002.02796.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12167125 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036378350 (DOI: 10.1046/j.1440-1746.2002.02796.x, PubMed: 12167125, Elsevier: Scopus)
17.	N. Uemura, Masahiro Nomura, S. Inoue, J. Endo, S. Kishi, Ken Saito, Susumu Ito and Yutaka Nakaya : Changes in Hemodynamics and Autonomic Nervous Activity in Patients Undergoing Laparoscopic Cholecystectomy:Differences Between the Pneumo-Peritoneum and Abdominal Wall-Lifting Method, Endoscopy, Vol.34, No.8, 643-650, 2002. (Summary) Intraoperative changes in circulatory hemodynamics and autonomic nervous activity were evaluated in 33 patients with cholelithiasis who underwent laparoscopic cholecystectomy. Of these patients, 18 were treated using a pneumoperitoneum (group G) and 15 using the abdominal wall-lifting method (group WL). Their ECG, blood pressure, arterial oxygen saturation, and expiratory carbon dioxide partial pressure were monitored. Autonomic nervous function was evaluated by spectral analysis of the heart rate. Mean blood pressure increased significantly in group G during surgery, but did not vary in group WL during any stage of surgery. The high-frequency (HF) power, an index of parasympathetic activity, decreased significantly in group G after pneumoperitoneum. However, the HF power did not decrease significantly in group WL. The LF/HF ratio, an index of sympathetic activity, increased significantly in group G after pneumoperitoneum, but did not vary in group WL. In addition, the incidence of ventricular or supraventricular arrhythmias and the severity of the arrhythmias as determined by Lown's classification were higher in group G than in group WL. These findings suggest that intraoperative changes in autonomic nervous activity, due to increased intra-abdominal pressure, were smaller in patients undergoing laparoscopic cholecystectomy using the abdominal wall-lifting method than in those undergoing laparoscopic cholecystectomy using pneumoperitoneum. The results also demonstrated that hemodynamic changes were smaller in patients undergoing the abdominal wall-lifting method than in those undergoing pneumoperitoneum. It was concluded that hemodynamics should be carefully monitored during pneumoperitoneum, and that the abdominal wall-lifting approach in laparoscopic cholecystectomy is a method worthy of consideration for elderly patients or those with cardiopulmonary complications. (Keyword) Abdominal Muscles / Aged / Aged, 80 and over / Autonomic Nervous System / blood pressure / Cholecystectomy, Laparoscopic / Cholelithiasis / female / Humans / Intraoperative Period / male / Middle Aged / Pneumoperitoneum, Artificial (Link to Publication Site) ● Publication site (DOI): 10.1055/s-2002-33252 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12173086 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036023116 (DOI: 10.1055/s-2002-33252, PubMed: 12173086, Elsevier: Scopus)
18.	Masahiro Nomura, 伊賀彰子, 日浅亜弥, 川口律子, 超智由恵, Akiyoshi Nishikado, 大木崇, Susumu Ito, Ken Saito, Yutaka Nakaya and 七條茂文 : トータル·ヘルス·プロモーション·プランによるインスリン抵抗性と最大酸素摂取量への効果, Heart, Vol.34, No.2, 38-40, 2002.
19.	Masahiro Nomura, Yutaka Nakaya, Hitoshi Miyajima, H Nada, Yoshie Ochi, Ritsuko Kawaguchi, S Morishita, Akiyoshi Nishikado, Hiroshi Shibata, Hirohito Honda, Ken Saito and Susumu Ito : Detection of myocardial damage caused by hepatitis C virus using signal averaged electrocardiogram and I-BMIPP myocardial scintigraphy, Journal of Electrocardiology, Vol.30, 379-383, 2002.
20.	Hitoshi Miyajima, Masahiro Nomura, Naoki Muguruma, Toshiya Okahisa, Seisuke Okamura, Hirohito Honda, Ichiro Shimizu, Masafumi Harada, Ken Saito, Yutaka Nakaya and Susumu Ito : Relationship among gastric motility,autonomic activity,and portal hemodynamics in patients with liver cirrhosis, Journal of Gastroenterology and Hepatology, Vol.16, No.6, 647-659, 2001. (Summary) We examined the effects of the autonomic nervous function and the volume of portal blood flow to clarify the mechanism of the abnormal gastric motility in patients with liver cirrhosis. Heart rate variability, electrogastrogram (EGG), and volume of portal blood flow were measured before and after a meal in 27 patients with liver cirrhosis (LC group) and in 20 normal subjects (N group). Autonomic nervous function was evaluated by using spectral analysis of heart rate variability. We used the cine phase-contrast (PC) method, using magnetic resonance imaging (MRI) to measure the portal flow, while the peak frequency and spectral power of the EGG were measured at pre- and postprandial change. The ratio of low frequency power to high frequency power (LF/HF) was significantly higher, and the HF power was significantly lower in the LC group than in the N group both before and after a meal. In both groups, the electrogastrographic peak power ratio before and after a meal showed a positive correlation with the HF ratio, and an inverse correlation with the LF/HF ratio. In addition, portal blood flow volume was significantly decreased in the LC group than in the N group. However, the increased rate of portal blood flow after a meal correlated positively with the increased rate of electrogastrographic peak power. Moreover, gastric motility was positively correlated with esophageal varices and coma scale with the use of multivariate analysis. Parasympathetic hypofunction, sympathetic hyperfunction and portal hemodynamics were closely related with gastric motility in cirrhotic patients. In addition, gastric motility was decreased, at least in part, by the ingestion of food in cirrhotic patients because of abnormalities in autonomic functions and portal blood flow following a meal. (Keyword) Aged / Autonomic Nervous System / Electrophysiology / Female / Gastrointestinal Motility / Heart Rate / Hemodynamics / Humans / Liver Cirrhosis / Magnetic Resonance Imaging / Male / Middle Aged / Portal System (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1440-1746.2001.02493.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11422618 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035722279 (DOI: 10.1046/j.1440-1746.2001.02493.x, PubMed: 11422618, Elsevier: Scopus)
21.	宮島等, Masahiro Nomura, 澤田幸, 森下智文, 名田智美, Tetsuzo Wakatsuki, Akiyoshi Nishikado, Ken Saito, 大木崇, Susumu Ito, Masafumi Harada, Hiromu Nishitani and Yutaka Nakaya : 摂食による冠動脈血流速度の変化，胃電図および冠動脈シネMRAを用いた検討, Heart, Vol.33, No.suppl 2, 7-10, 2001.
22.	Akiyoshi Nishikado, Masahiro Nomura, Ken Saito and Yutaka Nakaya : 心房細動治療に関するアンケート調査 ‐徳島県と全国の比較‐, Cardioangiology, Vol.49, 560-561, 2001.
23.	T Nada, Masahiro Nomura, A Iga, R Kawaguchi, Y Ochi, Ken Saito, Yutaka Nakaya and Susumu Ito : Autonomic nervous function in patients with peptic ulcer studied by spectral analysis of the heart rate variability, Journal of Medicine, Vol.32, No.5-6, 333-347, 2001. (Summary) This study is intended to clarify the relationship between occurrence of peptic ulcer disease and dysfunction of the autonomic nervous system. We studied heart rate variability and assessed the circadian rhythm of autonomic nervous function in 20 patients with peptic ulcer (PU group) and 20 age-matched healthy controls (N group) using 24-hour Holter monitoring. Moreover, the relationship between gastric juice secretion and autonomic activity was examined under intravenous injection of insulin or butylscopolamine in adult mongrel dogs. High frequency spectral (HF) power, an indicator of parasympathetic tone, was increased markedly at night in the PU group. Low frequency spectral (LF) power, an indicator of sympathetic tone modified by vagal tone, was higher during the day than at night in the N group, whereas this normal circadian rhythm of LF power disappeared in 11 cases (55%) in the PU group. In addition, the LF power was increased significantly at night (p<0.01) in the PU group. HF power and gastric juice secretion was increased by the administration of insulin. High sympatho-vagal tone at night may result in spasm of gastric arteries and excess secretion of gastric acid in the PU group. These results suggest that the nocturnal acceleration of LF, HF, and LF/HF is related to peptic ulcer diseases. (Keyword) Adult / Aged / Animals / Autonomic Nervous System / Dogs / Electrocardiography, Ambulatory / female / Gastric Juice / Heart Rate / Helicobacter Infections / Helicobacter pylori / Humans / male / Middle Aged / Peptic Ulcer / Reference Values (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11958279 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035735950 (PubMed: 11958279, Elsevier: Scopus)
24.	森下智文, Masahiro Nomura, 宮島等, 名田智美, Akiyoshi Nishikado, Ken Saito, 大木崇, Susumu Ito, 堀安裕子, Masafumi Harada, Hiromu Nishitani and Yutaka Nakaya : 99mTc-MIBIによる運動負荷時冠血流増加率と冠動脈血流速波形との関連, Heart, Vol.33, No.suppl 2, 91-94, 2001.
25.	Masahiro Nomura, K Fujimoto, A Higashino, M Denzumi, M Miyagawa, H Miyajima, T Nada, Y Kondo, Y Tada, R Kawaguchi, T Morishita, Ken Saito, Susumu Ito and Yutaka Nakaya : Stress and coping behavior in patients with diabetes mellitus., Acta Diabetologica, Vol.37, No.2, 61-64, 2000. (Summary) Diabetes mellitus is a disease which must be controlled over the lifetime of a patient. We investigated the issues of stress and coping for diabetes mellitus which may influence self-management. In addition, we examined the association of these factors with blood glucose control, in order to review self-management instructions for diabetes mellitus. The study included 153 patients with diabetes mellitus. The patients were divided into two subgroups: good-control group, comprising patients with glycohemoglobin (HbA1c) values less than 7.0%; and poor-control group, comprising those with HbA1c values of 7.0% or more. All patients responded to a questionnaire regarding stress tolerance, Jalowiec and Power's coping scale and awareness of diabetes mellitus. Stress tolerance was not significantly different between the good-control and poor-control groups. No significant gender differences in coping score were evident for the good-control group. However, in the poor-control group, the coping score in men was significant higher than that in women. The problem-oriented coping score for men in the poor-control group was significantly higher than that for the good-control group (p < 0.01). In a comparison of awareness of diabetes mellitus, the proportion of patients who replied that they were rigidly following diabetes treatment was higher in the poor-control group than the good-control group. Patients with diabetes mellitus may have a knowledge of the disease and a strong will to resolve problems. This is especially true for male patients in that their will appeared to be stronger, but they may not have the resolve to establish appropriate behavior patterns. In the future, methods for evaluating self-management should be included in diabetes education. (Keyword) Adaptation, Psychological / Aged / Awareness / diabetes mellitus / Emotions / female / Humans / male / Middle Aged / problem solving / Stress, Psychological / Surveys and Questionnaires (Link to Publication Site) ● Publication site (DOI): 10.1007/s005920070020 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11194928 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034529992 (DOI: 10.1007/s005920070020, PubMed: 11194928, Elsevier: Scopus)
26.	Ayako Tamura, Takako Ichihara, Takako Minagawa, Ken Saito, 山口智子, 藤本理恵子, 宮本節子, 長井明子, 平田佳子 and 羽藤佳代子 : ベット上における背面解放と非解放の座位姿勢時の自律神経活動の変化, 臨床看護研究の進歩, Vol.12, 95-100, 2000.
27.	Kazuhiro Tezuka, Masahiro Nomura, Ken Saito, Yoshikazu Takeuchi, Ryusuke Torisu, Mitsuyasu Yano, Yutaka Nakaya and Susumu Ito : Changes in autonomic nervous activity during colonoscopy using spectral analysis heart rate variability., Digestive Endoscopy, Vol.12, No.2, 155-161, 2000. (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1443-1661.2000.00028.x (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0034104988 (DOI: 10.1046/j.1443-1661.2000.00028.x, Elsevier: Scopus)
28.	Masahiro Nomura, Michiko Yukinaka, Hitoshi Miyajima, Tomomi Nada, Yuki Kondo, Toshiya Okahisa, Hiroshi Shibata, Seisuke Okamura, Hirohito Honda, Ichiro Shimizu, Ken Saito, T. Oki, Yutaka Nakaya and Susumu Ito : Is autonomic dysfunction a necessary condition for chronic peptic ulcer formation ?, Alimentary Pharmacology & Therapeutics, Vol.14suppl, No.1, 82-86, 2000. (Summary) The relationship between 1/f fluctuation of the heart rate variability and Helicobacter pylori infection was evaluated, in order to clarify whether autonomic nervous dysfunction is a necessary condition for chronic peptic ulcer formation. The subjects were 11 patients with recurrent chronic peptic ulcer and 20 age-matched normal subjects. Holter ECGs were recorded over 24 h, and the 1/f(-x) fluctuation of the heart rate was computed. The 1/f(-x) fluctuation of the heart rate is a novel index of autonomic function that has been shown to reflect a patient's pleasant mood. For 1/f(-x) fluctuation, the slope of the regression line (-x) was determined and cosine fitting of the absolute slope of the regression line over a 24-h period was performed. For the normal group, the absolute slope of the regression line during daytime and night-time were 0.53 +/- 0.16 and 1.05 +/- 0.18, respectively. For the peptic ulcer group, the corresponding values during daytime and night-time were 0.94 +/- 0.15 and 1.84 +/- 0.18, respectively. The mean value of the cosine curve was 0.76 +/- 0.23 in the normal group and 1.12 +/- 0.25 in the peptic ulcer group. Thus, these values were significantly higher for the latter group than for the former group (P<0.05). No statistically significant difference in H. pylori infection between the two groups was observed. Autonomic nervous dysfunction as well as H. pylori infection appears to be a necessary condition for chronic peptic ulcer formation. (Keyword) Aged / Autonomic Nervous System Diseases / Chronic Disease / Electrocardiography / Female / Heart Rate / Helicobacter Infections / Helicobacter pylori / Humans / Male / Middle Aged / Peptic Ulcer (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1365-2036.2000.014s1082.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10807408 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034127977 (DOI: 10.1046/j.1365-2036.2000.014s1082.x, PubMed: 10807408, Elsevier: Scopus)
29.	Michiko Yukinaka, Masahiro Nomura, Tetsuya Saijyo, Tomomi Nada, Hitoshi Miyajima, Yuki Kondo, Ken Saito, Yutaka Nakaya and Susumu Ito : Evaluation of autonomic nervous function in patients with essential hypertension complicated with peptic ulcer, Journal of Gastroenterology and Hepatology, Vol.15, No.1, 40-44, 2000. (Link to Publication Site) ● Publication site (DOI): 10.1046/j.1440-1746.2000.02052.x (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0034092721 (DOI: 10.1046/j.1440-1746.2000.02052.x, Elsevier: Scopus)
30.	H Miyajima, Masahiro Nomura, T Nada, Y Kondo, M Yukinaka, Ken Saito, Y Tada, Susumu Ito and Yutaka Nakaya : Age-related changes in the magnitude of ventricular depolarization vector : analyses by magnetocardiogram, Journal of Electrocardiology, Vol.33, No.1, 31-35, 2000. (Summary) The magnetocardiogram has the beneficial feature that permits the strength and location of the current dipole to be estimated. This study examines the issue of whether the magnitude of the heart current during depolarization phase was influenced by the age of healthy subjects. The magnetocardiograms were recorded by means of a second-derivative SQUID (superconducting quantum interference device) magnetometer (BT Corp, Model BMP, San Diego, CA) in 150 healthy subjects. The subjects were subgrouped into 5 age-based categories according to the age. The current dipole of the maximum QRS complex was determined from isofield contour maps during the ventricular depolarization phase, and no significant differences were observed in the magnitude in the current source for any age category. However, the amplitudes of the RV5 and SV1 + RV5 in the standard electrocardiogram were larger in 65 to 74-year-old women than other age groups, and the SV1 + RV5 was smaller for the 45 to 74-year-old men than for the men aged 25 to 44 years. These findings suggest that the age-associated changes in the QRS complex observed by the electrocardiogram are caused by increased electric resistance and not by the heart current itself. The results additionally suggest that no effects of aging were observed in the actual heart current of the heart during the depolarization phase. (Keyword) Action Potentials / Adult / Aged / aging / Electric Impedance / Electrocardiography / Electromagnetic Fields / female / heart / Heart Ventricles / Humans / male / Middle Aged (Link to Publication Site) ● Publication site (DOI): 10.1016/S0022-0736(00)80098-9 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10691172 ● Search Scopus @ Elsevier (PMID): 10691172 ● Search Scopus @ Elsevier (DOI): 10.1016/S0022-0736(00)80098-9 (DOI: 10.1016/S0022-0736(00)80098-9, PubMed: 10691172)
31.	Masahiro Nomura, 川口律子, 近藤幸, 宮島等, 多田由恵, 森下智文, Akiyoshi Nishikado, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 高齢者における食事負荷による血圧変動の成因ー心拍変動解析および胃電図における検討ー, Heart, Vol.32, No.suppl 2, 71-73, 2000.
32.	Masahiro Nomura, Yutaka Nakaya, 宮島等, 名田智美, Ken Saito and Susumu Ito : 心磁図法を用いた心臓異常所見の検出:心電図法で捉えられない心起電力を検出できるか, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.13, 28-29, 2000.
33.	Masahiro Nomura, Ritsuko Kawaguchi, Michiko Yukinaka, 近藤幸, 宮島等, 名田智美, 多田由恵, Ken Saito, Naoki Muguruma, Toshiya Okahisa, Hiroshi Shibata, Seisuke Okamura, Hirohito Honda, Ichiro Shimizu, Susumu Ito and Yutaka Nakaya : 高齢者における食後低血圧の成因, 日本高齢者消化器医学会議会誌, Vol.1, No.2, 36-41, 1999.
34.	Masahiro Nomura, Yutaka Nakaya, Tomomi Nada, Hitoshi Miyajima, Yuki Kondo, Ken Saito and Susumu Ito : Evaluation of Cardiac Function in Myocardial Infarction Patients by ECG 99mTc-MIBI Gated SPECT Using a Three-dimensional Perfusion/Motion Map Procedure, Japanese Heart Journal, Vol.40, No.4, 413-425, 1999. (Summary) Three-dimensional (3D) radionuclear myocardial imaging has improved the evaluation of left ventricular wall motion. However, there have been no studies evaluating left ventricular function using 3D-perfusion/motion map techniques. We hypothesized that the 3D-perfusion/motion map could accurately evaluate left ventricular wall motion even in patients with a history of myocardial infarction. Electrocardiogram (ECG)-gated single photon emission computed tomography (SPECT) using 99mTc-methoxy isobutyl isonitrile (MIBI) was performed in 20 patients with a history of myocardial infarction who underwent left ventriculography. Myocardial imaging data were collected during ECG-gated SPECT using a 3-headed gamma camera. Reconstructed 3D SPECT images were oriented to correspond to standard left ventriculography views (right anterior oblique and left anterior oblique projections), and the shortening fraction (SF) was calculated using the center line method. The SF and left ventricular ejection fraction from 3D SPECT images were compared with those determined by left ventriculography. There was a significant correlation between left ventriculography and the 3D-perfusion/motion map procedure in determining SF for all regions of the left ventricle except the anterobasal and posterior segments by using the Bland and Altman method. The 3D-perfusion/motion map procedure offers the advantage that the influences of contraction-related myocardial torsion and three-dimensional compression are minimized. In addition, this method facilitates evaluation of images from nonstandard projections. We conclude that this method may be useful for evaluating left ventricular function. (Keyword) Aged / Electrocardiography / female / Gated Blood-Pool Imaging / heart / Humans / male / Middle Aged / Myocardial Contraction / Myocardial Infarction / Perfusion / Technetium Tc 99m Sestamibi / Tomography, Emission-Computed, Single-Photon / Ventricular Function, Left (Link to Publication Site) ● Publication site (DOI): 10.1536/jhj.40.413 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10611906 ● Summary page in Scopus @ Elsevier: 2-s2.0-0032863079 (DOI: 10.1536/jhj.40.413, PubMed: 10611906, Elsevier: Scopus)
35.	井上千尋, 岡本充栄, 阿部房江, 島健二 and Ken Saito : Two cases who died suddenly of dissecting aneurysm of aorta during monitoring with Holter ECG, Japanese Journal of Medical Technology, Vol.48, No.2, 145-149, 1999. (Keyword) 心臓突然死 / 解離性大動脈瘤 / ホルター心電図 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1574231875020211200 (CiNii: 1574231875020211200)
36.	Masahiro Nomura, 宮島等, 名田智美, 近藤幸, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 僧帽弁逸脱におけるT wave alternanceの意義, Heart, Vol.31, No.suppl 2, 96-98, 1999.
37.	Masahiro Nomura, 宮島等, 名田智美, 近藤幸, 由岐中道子, 多田由恵, Ken Saito, Susumu Ito and Yutaka Nakaya : QT dispersionの臨床的意義:心臓磁界を用いた左室肥大における検討, 生体磁気学会雑誌, Vol.12, 122-123, 1999.
38.	Tetsuya Saijo, Masahiro Nomura, Yutaka Nakaya, Ken Saito, Yuki Kondo, Michiko Yukinaka, Ichiro Shimizu and Susumu Ito : Assessment of autonomic nervous activity during gastrointestinal endoscopy, Journal of Gastroenterology and Hepatology, Vol.13, 816-820, 1998.
39.	Masahiro Nomura, T Nada, J Endo, Y Kondo, M Yukinaka, Ken Saito, Susumu Ito, H Mori, Yutaka Nakaya and H Shinomiya : Brugada syndrome associated with an autonomic disorder, Heart, Vol.80, No.2, 194-196, 1998. (Keyword) Brugada syndrome / autonomic disorder / 123I-MIBG myocardial scintigraphy
40.	Masahiro Nomura, 由岐中道子, 近藤幸, 名田智美, 遠藤純子, 岸史子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : Dihydropridine系Ca拮抗薬の心臓交感神経機能への影響, Heart, Vol.30, No.suppl 3, 98-100, 1998.
41.	Masahiro Nomura, Yutaka Nakaya, T Nada, J Endo, Y Kondo, M Yukinaka, Ken Saito and Susumu Ito : Effects of intravenous administration of L-arginine on autonomic nervous activities: Analysis of heart rate variability, Japanese Heart Journal, Vol.39, 331-338, 1998.
42.	Y Kondo, Masahiro Nomura, T Nada, J Endo, M Yukinaka, Ken Saito, S Ichkawa, Susumu Ito and Yutaka Nakaya : Ischaemic electrocardiographic changes after massive blood transfusion : Findings based on myocardial scintigraphy using 99mTc-MIBI and 123I-MIBG, Acta Cardiologica, Vol.53, No.5, 279-283, 1998. (Summary) We performed myocardial scintigraphy on a patient with ischaemic electrocardiographic changes after massive blood transfusion. Although there was no defect by 99mTc-MIBI scintigraphy, 123I-MIBG scintigraphy was observed suggesting denervation after massive blood transfusion. Myocardial scintigraphy using 99mTc-MIBI or 123I-MIBG can be useful for the evaluation of myocardial dysfunction with reversible myocardial infarction. (Keyword) 3-Iodobenzylguanidine / Aged / Blood Transfusion / Electrocardiography / Gastrointestinal Hemorrhage / Humans / male / Myocardial Infarction / Radionuclide Imaging / Radiopharmaceuticals / Technetium Tc 99m Sestamibi (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9922806 ● Search Scopus @ Elsevier (PMID): 9922806 (PubMed: 9922806)
43.	Tetsuya Saijyo, Masahiro Nomura, Yutaka Nakaya, Ken Saito and Susumu Ito : Autonomic nervous system activity during infusion of L-arginine in patients with liver cirrhosis, Liver, Vol.18, 27-31, 1998.
44.	板東浩, 藤中真一, 斎藤晴比古, 島健二, 斎藤史郎, Mitsuo Itakura, Toshio Matsumoto, Masamichi Kuwajima, Ken Saito, 川島周, 鶴尾美穂, 杉本紀子, 杉本順子, 清水寛, 江藤和子, 桜井えつ, 近藤彰, 林健司, 福島康江, 赤池瞳, 岩田坤, 住友辰次, 小川紘一, 松村光博, 矢野勇人, 川内茂徳, 福田克之, 竹田勝則, 筒井芳彦, 橋本吉弘, 米田弘, 土橋孝之, 溝渕樹, 石川雅康, 木村建彦, 大倉敏裕, 高田幸伸, 高橋秀夫, 石川由子, 曽根佳世子, 阿部多賀子, 和田美智子 and 十枝紀巳代 : Current micro-and Macroangiopathic Complication of Diabetic Patients by Primary Care Physicians on Multicenter-study, 日本プライマリ·ケア学会誌, Vol.20, No.1, 46-51, 1997. (Keyword) diabetes mellitus / Macroangiopathy / Complication / Microangiopathy / epidemiology (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1572824500135153920 (CiNii: 1572824500135153920)
45.	Masahiro Nomura, Yutaka Nakaya, 由岐中道子, 近藤幸, Ken Saito and Susumu Ito : 心磁図法によるQTc dispersion:心筋梗塞による検討, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.10, 96-97, 1997.
46.	Masahiro Nomura, Yutaka Nakaya, F Kishi, Y Kondo, M Yukinaka, Ken Saito and Susumu Ito : Signal averaged electrocardiogram after exercise in patients with mitral valve prolapse, Journal of Medicine, Vol.28, No.1&2, 62-74, 1997. (Summary) While late potentials are correlated with an increased incidence of ventricular tachycardia, they are not necessarily a good predictor of ventricular electrical instability in patients with mitral valve prolapse (MVP). Our objective was to determine whether the signal averaged electrocardiogram (SAECG) after exercise can discriminate groups with a higher frequency of ventricular arrhythmia from those without. The SAECG was recorded before and after treadmill exercise in 20 normal subjects (N group), 20 patients with MVP (MVP group) and 10 patients with old myocardial infarction (MI group). Five patients (25%) in the MVP group and two patients (33%) in the MI group had late potentials before exercise. Late potentials in the MI group did not disappear with exercise, whereas they disappeared with exercise in two patients in the MVP group. The results suggest that the late potentials observed in patients with MVP differ in nature from those with old myocardial infarction and are not always related to lethal arrhythmia. (Keyword) Adult / Aged / Arrhythmias, Cardiac / Case-Control Studies / Electrocardiography / Exercise / Exercise Test / female / Humans / male / Middle Aged / Mitral Valve Prolapse / Myocardial Infarction (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9249612 ● Search Scopus @ Elsevier (PMID): 9249612 (PubMed: 9249612)
47.	岸史子, Masahiro Nomura, 由岐中道子, Ken Saito, Tomotsugu Tabata, 井内新, 福田信夫, 大木崇, Susumu Ito and Yutaka Nakaya : Evaluation of Myocardial Sympathetic Nerve Function in Patients With Mitral Valve Prolapse Using Iodine-123-Metaiodobenzylguanidine Myocardial Scintigraphy, Journal of Cardiology, Vol.27, No.Suppl II, 21-283, 1996. (Keyword) radionuclide imaging (iodine-123-metaiodobenzylguanidine myocardial scintigraphy) / mitral valve prolapse / sympathetic nerve function / washout rate (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573105974290242560 (CiNii: 1573105974290242560)
48.	Fumiko Kishi, Yutaka Nakaya, Akira Takahashi, Hirokazu Miyoshi, Masahiro Nomura and Ken Saito : INTRACELLULAR AND EXTRACELLULAR Ca²⁺REGULATE HISTAMINE-INDUCED RELEASE OF NITRIC OXIDE IN VASCULAR ENDOTHELIAL CELLS AS SHOWN WITH SENSITIVE AND SELECTIVE NITRIC OXIDE ELECTRODES, Pharmacological Research, Vol.33, No.2, 123-126, 1996. (Keyword) calcium / histamine / endothelium / electrodes / nitric oxide (Link to Publication Site) ● Publication site (DOI): 10.1006/phrs.1996.0018 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1006/phrs.1996.0018 (DOI: 10.1006/phrs.1996.0018)
49.	Masahiro Nomura, Yutaka Nakaya, F Kishi, Ken Saito, A Shinohara, Susumu Ito, H Yamamoto, J Syoji, Y Ohkita and S Orino : A 90-year old patient with atrial septal defect and sinus rhythm, Acta Cardiologica, Vol.51, No.4, 377-380, 1996. (Summary) A 90-year old patient with an atrial septal defect (ASD) and sinus rhythm, but no history of atrial fibrillation of heart failure is presented. Literature searches revealed no similar report of such a case. In addition, this patient represents the oldest documented patients with ASD associated and sinus rhythm. (Keyword) Age Factors / Aged / Aged, 80 and over / Electrocardiography / Heart Rate / Heart Septal Defects, Atrial / Humans / Male (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8888895 ● Search Scopus @ Elsevier (PMID): 8888895 (PubMed: 8888895)
50.	Masahiro Nomura, 由岐中道子, 岸史子, Ken Saito, Susumu Ito and Yutaka Nakaya : 特発性心筋症における初期QRSベクトルの信号源, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.9, 194-195, 1996.
51.	Masahiro Nomura, Yutaka Nakaya, 渡部克介, 岸史子, Ken Saito, 三好宏和, 西條哲也, 由岐中道子, 大木崇 and Susumu Ito : L-アルギニン静脈注射による自律神経活動の影響:心拍変動解析による検討, Heart, Vol.28, No.Suppl 5, 31-32, 1996.
52.	Masahiro Nomura, 岸史子, 由岐中道子, 近藤幸, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 長時間運動負荷後の回復過程のエネルギー代謝と自律神経活動の検討‐呼気ガス分析と心拍変動解析による検討, Heart, Vol.29, No.Suppl 4, 73-75, 1996.
53.	Masahiro Nomura, Yutaka Nakaya, Fumiko Kishi, Michiko Yukinaka, Ken Saito, Hiroshi Shibata and Susumu Ito : Heart rate variability during painful medical procedures(Percutaneous ethanol injection therapy), Electrocardiology '96 from the cell to the body surface, 395-398, 1996.
54.	Hirokazu Miyoshi, Yutaka Nakaya, Ken Saito, Fumiko Kishi, Masahiro Takakura and Masahiro Nomura : MCI-154 activates the Ca²⁺-activated K⁺ channel of vascular smooth muscle cells, Life Sciences, Vol.56, No.15, PL291-PL298, 1995. (Link to Publication Site) ● Publication site (DOI): 10.1016/0024-3205(95)00079-8 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/0024-3205(95)00079-8 (DOI: 10.1016/0024-3205(95)00079-8)
55.	Masahiro Nomura, 大木崇, Ken Saito, Yutaka Nakaya, 岸史子, 三好宏和, Tomotsugu Tabata, 井内新, 佐々木美和, 福田信夫 and Susumu Ito : 僧帽弁逸脱における運動負荷時の心拍変動スペクトルの検討, Heart, Vol.27, No.Suppl 5, 52-53, 1995.
56.	Yutaka Nakaya, Masahiro Nomura, 岸史子, 三好宏和, Ken Saito and Susumu Ito : 前壁心筋梗塞症および健常例の初期QRSベクトルの信号源推定, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.8, 302-305, 1995.
57.	Hirokazu Miyoshi, F Kishi, K Watanabe, Masahiro Nomura, Ken Saito and Yutaka Nakaya : Nonendothelial-derived nitric oxide activates the K+ channels in cultured vascular smooth muscle cells, Heart and Vessels, Vol.9, No.suppl, 109-111, 1995.
58.	Masahiro Nomura, 大木崇, Tomotsugu Tabata, 三好由貴子, 井内新, 清重浩一, 藤本卓, Ken Saito, 福田信夫, Yutaka Nakaya, 伊東進, Masanori Yoshizumi, Yutaka Masuda, Tetsuya Kitagawa and 加藤逸夫 : 僧帽弁逸脱における血中遊離型および硫酸抱合型カテコールアミンの変動, Heart, Vol.26, No.3, 27-29, 1994.
59.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, F Kishi, Tetsuzo Wakatsuki, Hirokazu Miyoshi, Akiyoshi Nishikado, Shigenobu Bando, Susumu Ito, Hiromu Nishitani, Masao Wada, Satoshi Fujita and Itsuro Tamura : Noninvasive localization of accessory pathways by magnetocardiographic imaging, Clinical Cardiology, Vol.17, No.5, 239-244, 1994. (Summary) The magnetocardiogram (MCG) is a newly developed method that helps localize a cardiac current source. To test the clinical accuracy of a 7-channel biomagnetic system in the localization of early ventricular depolarization sites, the MCGs of 14 patients with Wolff-Parkinson-White (WPW) syndrome were recorded in a radiofrequency-shielded room. The locations of early ventricular depolarization sites were classified by standard 12-lead electrocardiograms (ECGs) and body surface isopotential mapping. The accessory pathways of 3 patients with WPW syndrome were located in the right free wall and in 11 patients in the left free wall. The three-dimensional (3-D) dipole location was computed every 2 ms from the onset of the QRS complex by the least-square method. These 3-D dipole locations were projected onto a gated magnetic resonance image in order to visualize the propagation of the calculated ventricular source. The results were compared with those obtained by body surface isopotential mapping, and electrocardiographic and electrophysiologic studies. The location of the deduced current dipole at 20 ms correlated well with the location of the accessory pathway by the body surface mappings in 12 of the 14 patients with WPW syndrome. The MCG is capable of precisely determining the 3-D location of a current source in a noninvasive manner and may be of potential benefit in the treatment of WPW syndrome by catheter ablation. (Keyword) magnetocardiogram / Wolff-Parkinson-White syndrome / Magnetic resonance image (Link to Publication Site) ● Publication site (DOI): 10.1002/clc.4960170504 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8004837 ● Search Scopus @ Elsevier (PMID): 8004837 ● Search Scopus @ Elsevier (DOI): 10.1002/clc.4960170504 (DOI: 10.1002/clc.4960170504, PubMed: 8004837)
60.	Masahiro Kubo, Yutaka Nakaya, Suguru Matsuoka, Ken Saito and Yasuhiro Kuroda : Atrial Natriuretic Factor and Isosorbide Dinitrate Modulate the Gating of ATP-Sensitive K+ Channels in Cultured Vascular Smooth Muscle Cells, Circulation Research, Vol.74, No.3, 471-476, 1994. (Keyword) isosorbide dinitrate / vascular smooth muscular cells / 8-bromo-cGMP / ATP-sensitive K+ channels / atrial natriuretic factor
61.	Ken Saito, Yutaka Nakaya, Y Miyoshi, Tetsuzo Wakatsuki, M. Nomura and Masayuki Shono : Effects of vesnarinone (OPC-8212) on Ca(2+)-activated K channels and cytosolic Ca2+ in cultured smooth muscle cells from porcine coronary artery., Japanese Heart Journal, Vol.35, No.1, 61-71, 1994. (Summary) Vesnarinone is a new, non vasodilating cardiotonic agent. This study compared the effects of vesnarinone and amrinone, a phosphodiesterase (PDE) inhibitors with vasodilating actions, on cultured smooth muscle cells from the porcine coronary artery. Application of vesnarinone (10(-4) M) or amrinone (10(-4) M) to the bath solution in cell-attached patches activated the KCa channel having a conductance of 133 pS (bath 2.7 mM K, pipette 140 mM K). Application of vesnarinone to the cytosolic side had no direct effect on KCa channel activities in inside-out patches. Activation of the KCa channel was suppressed when the intracellular production of cAMP was suppressed by preincubation with carbachol (10(-6) M). Amrinone, but not vesnarinone, lowered [Ca2+]i in the K(+)-depolarized smooth muscle cells (K+ = 70 mM). These results suggest that vesnarinone exerts an additional effect on [Ca2+]i that is independent of PDE inhibition. The difference in the effects on [Ca2+]i in vascular smooth muscle cells may explain in part the differing actions of these agents on vascular relaxation. (Keyword) smooth muscle / cytosolic Ca2 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8201782 ● Search Scopus @ Elsevier (PMID): 8201782 (PubMed: 8201782)
62.	Ken Saito, Yutaka Nakaya, Yukiko Miyoshi, Tetsuzo Wakatsuki, Masahiro Nomura and M Shono : Effects of Vesnarinone(OPC-8212)on Ca²⁺-Activated K Channels and Cytosolic Ca²⁺- in Cultured Smooth Muscle Cells from Porcine Coronary Artery, Japanese Heart Journal, Vol.35, No.1, 61-71, 1994. (Keyword) Vesnarinone / Amrinone / Positive inotropic agents / Kca channel / [Ca2+]i
63.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, H Miyoshi, F Kishi, S Hibino, T Saijyo, Susumu Ito, K Nakagawa, Hideki Nakanishi, H Nagae, N Toda, S Tanaka, H Harada, K Matsumoto and T Hasagawa : Hemopneumothorax secondary to multiple cavitary metastasis in angiosarcoma of the scalp, Respiration, Vol.61, No.2, 109-112, 1994. (Summary) We report a case of hemopneumothorax secondary to multiple cavitary metastasis in the angiosarcoma of the scalp in an 86-year-old woman, who died of respiratory failure. At autopsy, multiple cavities were found in both lungs. Histologic specimen of the cavitary metastasis of the lung showed that tumor cells proliferated forming several tubular spaces and these tubular spaces seemed to communicate with the central cyst. These findings suggested that imperfect vessel-like structures of the cavitary metastasis are likely to break down and finally grow up to large thin-walled cavities. (Keyword) Aged / Aged, 80 and over / Female / Hemangiosarcoma / Hemopneumothorax / Humans / Lung / Lung Neoplasms / Scalp / Skin Neoplasms (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8008986 ● Search Scopus @ Elsevier (PMID): 8008986 (PubMed: 8008986)
64.	Masahiro Nomura, 大木崇, Tomotsugu Tabata, 三好由貴子, 井内新, 清重浩一, Ken Saito, 福田信夫, Yutaka Nakaya, Susumu Ito, Masanori Yoshizumi, Yutaka Masuda, Tetsuya Kitagawa and 加藤逸夫 : 僧帽弁逸脱における血中遊離型および硫酸抱合型カテコラミンの変動, Heart, Vol.26, No.Suppl 3, 27-29, 1994.
65.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 三好宏和, Susumu Ito, 田村逸郎, 和田昌夫 and 藤田智 : 心磁図法によるPベクトルの位置推定, 日本心電学会誌, Vol.14, No.Suppl 1, 82-83, 1994.
66.	Masahiro Nomura, 西條哲也, 岸史子, 三好宏和, Ken Saito, Yutaka Nakaya, 大木崇 and Susumu Ito : 肝硬変患者における自律神経機能:体表面平均加算化心電図法を用いた検討, Journal of Cardiology, Vol.24, No.Suppl 41, 102-104, 1994.
67.	Masahiro Nomura, Yutaka Nakaya, 岸史子, Ken Saito and Susumu Ito : 心磁図法による心房性再分極波(Ta波)の検討, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.7, 202-205, 1994.
68.	Yutaka Nakaya, Masahiro Nomura, Ken Saito, 岸史子 and Susumu Ito : 心筋梗塞症の初期QRSベクトルと心室再分極ベクトル-心磁図法による電流源の位置, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.7, 206-209, 1994.
69.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, F Kishi, H Miyoshi, K Watanabe, Susumu Ito, M Kubo and S Matsuoka : Time- and frequency-domain analyses of signal averaged electrocardiograms in patients with diabetes mellitus, Journal of Medicine, Vol.25, No.5, 271-283, 1994. (Summary) We recorded the signal-averaged electrocardiography (SAECG) of patients with diabetic retinopathy in order to clarify whether a ventricular conduction disturbance can be detected by time- or frequency-domain analysis of the SAECG. Twenty-four normal subjects (N group) and 20 patients with diabetic retinopathy [diabetes mellitus (DM) group] were studied. On time-domain analysis, the duration of the filtered QRS (f-QRS), the duration of the terminal QRS below 40 microV (LAS40) and the root-mean-square amplitude of the terminal 40 msec (RMS40) were measured. The frequency-domain analysis was performed using two windows. In each window, the ratio of the area under the spectral curve from 40 to 100 Hz was compared with that from 0 to 40 Hz and the area from 20 to 50 Hz was compared with that from 0 to 20 Hz. The LAS40 of the DM group was significantly prolonged when compared with the N group. The area ratio from 40 to 100 Hz versus 0 to 40 Hz significantly increased in the DM group when compared with the N group. These results suggest that SAECG can be used to detect abnormal electrical signals due to diabetic microangiopathy. Moreover, high frequency components of 40 to 100 Hz at the terminus of the QRS wave were most sensitive for abnormalities due to diabetic microangiopathy. (Keyword) Aged / Atrioventricular Node / Diabetic Angiopathies / diabetic retinopathy / Electrocardiography / female / Fourier Analysis / Humans / Incidence / male / Middle Aged / Signal Processing, Computer-Assisted / Time Factors (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7730734 ● Summary page in Scopus @ Elsevier: 2-s2.0-0028890838 (PubMed: 7730734, Elsevier: Scopus)
70.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, F Kishi and Susumu Ito : Circadian profile of heart rate variability in mitral valve prolapse syndrome, Japanese Heart Journal, Vol.57, No.suppl, 557-558, 1994.
71.	Tetsuya Saijo, Masahiro Nomura, Yutaka Nakaya, Ken Saito, F Kishi and Susumu Ito : Time- and frequency-domain heart rate variabilities in patients with liver cirrhosis, Japanese Heart Journal, Vol.35, No.suppl, 563-564, 1994.
72.	F Kishi, Masahiro Nomura, Yutaka Nakaya, Ken Saito and Susumu Ito : Relationship between the ischemic myocardium and focus of ventricular tachycardia in old myocardial infarction, Japanese Heart Journal, Vol.35, No.suppl, 563-564, 1994.
73.	大木崇, Ken Saito, 清重浩一, 長瀬教夫, 河原啓治 and 河野和弘 : effects of tarazosin hydrochloride on glucose metabolism and serum lipids in diabetic patients with essential hypertension, Therapeutic Research, Vol.14, No.9, 457-466, 1993. (Keyword) α1-blocker / essential hypertension / glucose metabolism / serum lipids
74.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 三好宏和, Susumu Ito, 和田昌夫, 藤田智 and 田村逸郎 : 心房興奮伝播のMRI画像上の表示‐心磁図法による電流dipoleの位置推定‐, Medical Imaging Technology, Vol.1, 551-558, 1993. (Link to Publication Site) ● Publication site (DOI): 10.11409/mit.11.551 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11409/mit.11.551 (DOI: 10.11409/mit.11.551)
75.	Masahiro Nomura, Yutaka Nakaya, Tetsuzo Wakatsuki, Yukiko Miyoshi, Fumiko Kishi, Ken Saito, Susumu Ito, Kimiko Nakayasu, Hiromu Nishitani, Kenji Matsuzaki, Shin-ichi Ueno, Itsuro Tamura, Masao Wada, Satoshi Fujita and Tsutomu Takae : Prediction of the site of origin of ventricular premature beat by magnetocardiogram, Heart, Vol.25, No.8, 907-913, 1993. (Summary) 心磁図による診断法を確立するために，生体内の電流源を三次元的に推定する心磁図法と，心電図同期MRI断層法を併用して，心室性期外収縮発生源の位置を推定した．推定された値は，体表面電位図法から推定される発生源とほぼ一致し，診断学的にも有用であることがわかった． (Keyword) 心磁図 / 心室性期外収縮 / MRI
76.	Ken Saito, 管由紀子, 中西一世, Eiji Hosoi, Masahiro Nomura and Yutaka Nakaya : 健常者の右側胸部誘導心電図所見に関する検討, Respiration & Circulation, Vol.41, No.6, 565-569, 1993. (Link to Publication Site) ● Publication site (DOI): 10.11477/mf.1404900682 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1404900682 (DOI: 10.11477/mf.1404900682)
77.	Yutaka Nakaya, Masahiro Nomura, 岸史子, Ken Saito and 森博愛 : 心磁図の臨床応用‐心室性不整脈の発生源の推定‐, マグネティックス研究会, Vol.MAG-93-94, 71-79, 1993.
78.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 三好宏和, Akiyoshi Nishikado, 坂東重信, Susumu Ito, 和田昌夫, 藤田智 and 田村逸郎 : SQUIDを用いた心房興奮伝播のMRI画像上の表示, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.6, 214-217, 1993.
79.	Yutaka Nakaya, Masahiro Nomura, 岸史子, Ken Saito, Akiyoshi Nishikado, 坂東重信 and Susumu Ito : 心室性不整脈の発生源の推定-心電図と心磁図の比較, The Journal of Japan Biomagnetism and Bioelectromagnetics Society, Vol.6, 210-213, 1993.
80.	Yutaka Nakaya, Masahiro Nomura, 三好由貴子, Tetsuzo Wakatsuki, Ken Saito, 上野慎一, 松崎健司 and Hiromu Nishitani : 7チャンネルSQUID磁束計による心臓磁界計測およびdipoleの位置推定, 日本臨床生理学会誌, Vol.23, 359-369, 1993.
81.	平岡葉月, 佐藤光代, 永峰康孝, Ken Saito, Eiji Hosoi and 百瀬圭三 : ホルター心電図による心房細動例の心電図的検討, 徳島県臨床衛生検査技師会誌, Vol.29, No.4, 187-190, 1992.
82.	Masahiro Nomura, Kimiko Nakayasu, Yutaka Nakaya, Yukiko Miyoshi, Tetsuzo Wakatsuki, Ken Saito, Shigenobu Bando and Susumu Ito : Single moving dipole obtained from magnetic field of the heart in patients with left ventricular hypertrophy, Clinical Cardiology, Vol.15, No.10, 752-758, 1992. (Summary) Magnetocardiograms (MCGs) were recorded by means of a second-derivative SQUID (superconducting quantum interference device) magnetometer in 20 normal subjects and 28 patients with left ventricular overload to analyze the activation sequence of the heart and amplitude of estimated current source. In the normal subjects, the dipole was directed to the left and gradually superiorly 40 ms after the beginning of the QRS wave mainly due to the activation of the left ventricle. In the patients with hypertension, the direction and location of the dipoles were similar to those of the normal subjects, but their dipole moments were increased. In the patients with mitral regurgitation, the dipoles of late QRS were directed more inferiorly than in the normal subjects and their amplitude was increased. In the patients with aortic valve disease, the amplitude of the dipoles was increased markedly and their location was deviated more to the left than the dipoles of the normal subjects. We established the criterion for diagnosis of LVO from the dipole moment of 50 ms of 3.13 x 10(-3) A or more. The sensitivity of this criterion is significantly higher in the diagnosis of left ventricular overload than the electrocardiogram (ECG). The present study shows that the moving dipole method is useful to determine the increased electromotive force in patients with left ventricular overload and that sensitivity in diagnosis of left ventricular overload is increased. (Keyword) magnetocardiogram / left ventricular overload / single moving dipole (Link to Publication Site) ● Publication site (DOI): 10.1002/clc.4960151013 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1395186 ● Search Scopus @ Elsevier (PMID): 1395186 ● Search Scopus @ Elsevier (DOI): 10.1002/clc.4960151013 (DOI: 10.1002/clc.4960151013, PubMed: 1395186)
83.	Yukiko Miyoshi, Yutaka Nakaya, Tetsuzo Wakatsuki, Shuichiro Nakaya, Kazuya Fujino, Ken Saito and Isao Inoue : Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine coronary artery, Circulation Research, Vol.70, No.3, 612-616, 1992.
84.	Tetsuzo Wakatsuki, Yutaka Nakaya, Yukiko Miyoshi, Masahiro Nomura, Ken Saito, RX Zeng, Susumu Ito and Isao Inoue : Effects of vasopressin on K+ channels of vascular smooth muscle cells, Therap Res, Vol.13, 311-317, 1992.
85.	三好由貴子, 中矢修一朗, Tetsuzo Wakatsuki, 藤野和也, Ken Saito, Yutaka Nakaya and Isao Inoue : 冠動脈平滑筋細胞におけるEndothelinの作用, Therapeutic Research, Vol.12, No.6, 121-126, 1991. (Keyword) ATP sensitive K channel / Smooth music cells / Endothelin / Nicorandil
86.	佐藤光代, 徳永敏枝, Ken Saito, 和田貴美子, Eiji Hosoi, 百瀬圭三 and 永峰康孝 : 健常者の肺気量変動に伴う心電図変化に関する検討, 徳島県臨床衛生検査技師会誌, Vol.28, 124-128, 1991.
87.	Q Yang, K Kiyoshige, T Fujimoto, M Katayama, K Fujino, Ken Saito, Yutaka Nakaya and H Mori : Signal-averaging electrocardiogram in patients with diabetes mellitus, Japanese Heart Journal, Vol.31, No.1, 25-33, 1990. (Keyword) Signal-averaging / Late potentials / Interventricular conduction defect / Diabetic cardiomyopathy (Link to Publication Site) ● Publication site (DOI): 10.1536/ihj.31.25 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.31.25 (DOI: 10.1536/ihj.31.25)
88.	松山清志 and Ken Saito : Diurnal variation of QT interval and prevalence of arrhythmia in idiopathic mitral valve prolapse, Shikoku Acta Medica, Vol.45, No.4, 265-275, 1989.
89.	Q Yang, K Kiyoshige, T Fujimoto, M Katayama, K Fujino, Ken Saito, Yutaka Nakaya and H Mori : Vector U loop in patients with old myocardial infarction, Clinical Cardiology, Vol.12, No.5, 277-282, 1989. (Summary) The U loop of the vectorcardiogram was examined qualitatively and quantitatively in 100 normal subjects and 67 patients with old myocardial infarction, using a direct-writing vectorcardiograph with memory function. In the control group, the U loop was directed to the left, anteriorly and inferiorly, and it was inscribed counterclockwise in the horizontal plane. In patients with anterior myocardial infarction, the U loop tended to be displaced to the right, and in patients with inferior myocardial infarction to the right and superiorly. The shape of the U loop in patients was also different from that of normal subjects. The maximum U vector was significantly smaller in magnitude both in patients with anterior and inferior myocardial infarction than that of normal subjects (p less than 0.01). In patients with ventricular aneurysm, the magnitude of the maximum U vector was significantly smaller and its direction was displaced more to the right and posteriorly than those without aneurysm (p less than 0.01). In standard 12-lead electrocardiogram (ECG), observation of the U wave in patients with old myocardial infarction was difficult, especially in the limb lead, because of the small size of the U wave. Therefore, vectorcardiographic observation may be more useful than electrocardiographic observation for the analysis of the U wave in patients with old myocardial infarction. (Keyword) U wave / U loop / vectorcardiogram / old myocardial infarction (Link to Publication Site) ● Publication site (DOI): 10.1002/clc.4960120510 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 2656022 ● Search Scopus @ Elsevier (PMID): 2656022 ● Search Scopus @ Elsevier (DOI): 10.1002/clc.4960120510 (DOI: 10.1002/clc.4960120510, PubMed: 2656022)
90.	佐藤光代, 中宮茂雄, 藤本順子, 島健二, 木村昌代, 中山小百合, Ken Saito and 百瀬圭三 : インテイジェント化心電計の診断精度に関する検討, 徳島県臨床衛生検査技師会誌, Vol.26, No.1, 15-21, 1989.
91.	Ken Saito, Yoshiharu Fukuda, Tomohiko Kawano, Tomoyuki Uchida, Toshihiko Tominaga, Nobuo Fukuda, Takashi Oki and Hiroyoshi Mori : Diurnal variation of the QT interval and effects of beta-receptor blockade in idiopathic mitral valve prolapse, Cardioangiology, Vol.23, No.5, 482-490, 1988. (Keyword) QTc / MVP / dysautonomia
92.	Ken Saito, 田口奈緒美, 宮生芳香, 百瀬圭三 and 森博愛 : ホルター式長時間呼吸·心電図記録装置による健常者無呼吸発作の観察, Respiration & Circulation, Vol.36, No.5, 539-543, 1988.
93.	Akemi Takeuchi, Katsusuke Watanabe, Masahiro Nomura, Shigeki Ishihara, Masaki Sumi, Masaru Murakami, Ken Saito, Yutaka Nakaya and Hiroyoshi Mori : The P wave in the magnetocardiogram, Journal of Electrocardiology, Vol.21, No.2, 161-167, 1988. (Summary) The P wave of the magnetocardiogram (MCG) was investigated in normal subjects and in patients with right and left atrial overloading. In normal subjects, the MCG P wave was positive at right lower sternal sites and negative in the other portions. The current source deduced from the MCG and the isomagnetic map was directed inferiorly and to the left throughout the entire phase of atrial activation. In patients with right atrial overloading, the direction of the current source deduced from the MCG was similar to that of normal subjects, but its amplitude was significantly greater. In left atrial overloadings, a negative-positive biphasic P wave was seen more frequently than in normal subjects at left parasternal sites. In the late phase of atrial activation, the MCG could detect the two dipoles, i.e. one directed inferiorly and other directed to the left. These dipoles might correspond to right and left atrial activities, respectively. These results show that the MCG might add useful information on current source to the conventional electrocardiogram. (Keyword) Adult / Atrial Function / Electrocardiography / Female / Heart Atria / Heart Conduction System / Heart Defects, Congenital / Heart Septal Defects, Atrial / Heart Valve Diseases / Humans / Magnetics / Male / Middle Aged / Prospective Studies / Retrospective Studies (Link to Publication Site) ● Publication site (DOI): 10.1016/S0022-0736(88)80012-8 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 3397699 ● Summary page in Scopus @ Elsevier: 2-s2.0-0023938364 (DOI: 10.1016/S0022-0736(88)80012-8, PubMed: 3397699, Elsevier: Scopus)
94.	Yutaka Nakaya, Akemi Takeuchi, Hideaki Nii, S Ishihara, Masahiro Nomura, Kazuya Fujino, Ken Saito and Hiroyoshi Mori : Isomagnetic maps in right ventricular overloading, Journal of Electrocardiology, Vol.21, No.2, 168-173, 1988. (Summary) Isomagnetic maps were recorded in normal subjects and in patients with systolic overloading of the right ventricle. The isomagnetic maps examined in this study indicated the instantaneous current source of the heart by applying the "corkscrew rule." The magnetic field recorded by a second derivative gradiometer detected clearly the cardiac current source from the right ventricle, which is located close to the anterior chest wall, and improved diagnostic sensitivity. Moreover, the isomagnetic map showed multiple dipoles, which are difficult to detect in the electrocardiogram or isopotential map. These results suggest that the magnetocardiogram provides useful information on current sources to supplement information obtained by the conventional electrocardiogram. (Keyword) Adult / Electric Conductivity / Electrocardiography / Female / heart / Heart Defects, Congenital / Heart Valve Diseases / Heart Ventricles / Humans / Magnetics / Male / Middle Aged / Reference Values / Ventricular Function (Link to Publication Site) ● Publication site (DOI): 10.1016/S0022-0736(88)80013-X (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 3397700 ● Summary page in Scopus @ Elsevier: 2-s2.0-0023926837 (DOI: 10.1016/S0022-0736(88)80013-X, PubMed: 3397700, Elsevier: Scopus)
95.	T Fujimoto, K Kiyoshige, Ken Saito, Masahiro Nomura, Q Yang, Yutaka Nakaya and H Mori : Vector U loop in patients with left ventricular overloading, Am. J. Noninvasive. Cardiol, Vol.2, 224-231, 1988.
96.	Mieko Ueki, Yutaka Nakaya, Kazuya Fujino, Masahiro Nomura, Yasunori Saito, Takashi Fujimoto, Koichi Kiyoshige, Ken Saito, Yoshikazu Hiasa and Hiroyoshi Mori : Vector U loop in patients with right ventricular overloading, Journal of Electrocardiology, Vol.20, No.5, 383-390, 1987. (Summary) The U loop of the vectorcardiogram (VCG) was examined qualitatively and quantitatively in 126 normal subjects, 15 subjects with complete right bundle branch block (CRBBB group) and 58 patients with right ventricular overloading (RVO group), using a direct-writing vectorcardiograph with memory function. In normal subjects the U loop was directed similarly to the T loop, i.e., to the left, anteriorly and inferiorly. In the CRBBB group, maximum U vector was smaller, but its direction was not significantly different from that in normal subjects. In the RVO group, the U loop tended to be displaced posteriorly and to the left and was significantly greater in magnitude than that in normal subjects in the horizontal (P less than 0.01) and frontal (P less than 0.001) planes. In the RVO group, a good correlation was found between the direction of maximum U vector and right ventricular systolic pressure. In some cases of the RVO group, the U loop was the only abnormality suggesting right ventricular overloading. These findings suggest that abnormality of the U loop is a good indicator in a diagnosis of right ventricular overloading. (Keyword) Adolescent / Adult / Aged / Aged, 80 and over / blood pressure / Electrocardiography / female / Heart Diseases / Heart Ventricles / Humans / male / Middle Aged / Vectorcardiography (Link to Publication Site) ● Publication site (DOI): 10.1016/S0022-0736(87)80090-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 3430107 ● Summary page in Scopus @ Elsevier: 2-s2.0-0023502058 (DOI: 10.1016/S0022-0736(87)80090-0, PubMed: 3430107, Elsevier: Scopus)
97.	森博愛, Ken Saito, 仁木敏晴, 河原啓治, 佐藤浩充, 日浅芳一, 太田重嘉, 澤田誠三, 和田泰男, 石本武男, 佐藤隆久, 寿満裕司 and 角谷昭佳 : 心室期外収縮に対するDisopyramideの抑制効果, The Japanese journal of clinical and experimental medicine, Vol.64, No.9, 242-251, 1987.
98.	Ken Saito, 香川千恵美 and 森博愛 : 非観血的連続記録血圧計による健常者の血圧日内変動様式の観察, Cardioangiology, Vol.20, No.5, 450-452, 1986. (Keyword) volume oscillometric method / ambulatory blood pressure / circadian variation of blood pressure
99.	Yoshiyuki Tamura, Tetsuo Nishimoto, Seiji Miyakami, Harunobu Sako, Ken Saito and Hiroyoshi Mori : Characteristics of ATPase activity and the subunit composition of myosin in the conduction system of bovine heart, FEBS Letters, Vol.178, No.2, 209-212, 1984. (Summary) The ATPase activity, light chains and isoenzymes of myosin from specialized myocardial tissue (the A-V node, bundle of His, and right and left bundle branches) of bovine heart were compared with those of atrial and ventricular myosins. The order of Ca2+-activated ATPase activity was atrial greater than specialized myocardial tissue greater than ventricular myosin. SDS-polyacrylamide gel electrophoresis showed that myosin from the specialized myocardial tissue contained the light chains of both atrial and ventricular myosins. On the other hand, the specialized myocardial tissue contained one V3 isomyosin and showed no difference from ventricular myocardial tissue on pyrophosphate gel. (Keyword) cardiac conduction system / Specialized myocardial tissue / Myosin / ATPase / Myosin light chain / Myosin isoenzyme (Link to Publication Site) ● Publication site (DOI): 10.1016/0014-5793(84)80602-x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 6239791 ● Summary page in Scopus @ Elsevier: 2-s2.0-0021703359 (DOI: 10.1016/0014-5793(84)80602-x, PubMed: 6239791, Elsevier: Scopus)
100.	松山清志, Ken Saito, 清水伸子 and 森博愛 : 実時間処理型ホルター心電計(PECGASYS)の心拍数および心室性期外収縮検出の信頼性に関する検討, 日本臨床生理学会雑誌, Vol.14, No.2, 138-143, 1984.
101.	Ken Saito, Kiyoshi Matsuyama, Toshiharu Niki and Hiroyoshi Mori : CHARACTERISTICS OF NON-SUSTAINED VENTRICULAR TACHYCARDIA DETECTED BY AMBULATORY ELECTROCARDIOGRAPHY, Japanese Circulation Journal, Vol.48, No.5, 421-426, 1984. (Keyword) Ventricular tachycardia / Life-threatening arrhythmia / Ambulatory electrocardiography / Prematurity / Diurnal variation (Link to Publication Site) ● Publication site (DOI): 10.1253/jcj.48.421 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1253/jcj.48.421 (DOI: 10.1253/jcj.48.421)
102.	Ken Saito, 松山清志, 仁木敏晴 and 森博愛 : Electrocardiographic features of ventricular tachycardia, --- especialiy its relationship to premature ventricular complexes ---, Journal of Clinical and Experimental Medicine, Vol.128, No.7, 453-457, 1984.
103.	田村禎通, 工藤隆, 佐光春信, 宮上盛史, Ken Saito, 長瀬教夫, 小林総一郎, 仁木敏晴 and 森博愛 : 心臓刺激伝導系ミオシンのアイソザイムおよびATPase活性, Journal of Clinical and Experimental Medicine, Vol.127, No.7, 725-728, 1983.
104.	長瀬教夫, 田村禎通, 小林総一郎, 宮上盛史, 佐光春信, 西本哲雄, Ken Saito, 仁木敏晴 and 森博愛 : EFFECTS OF ELASTASE ON THE MYOCARDIAL DISORDERS OF KK MICE, 心筋の構造と代謝, Vol.6, 53-60, 1983. (Keyword) K K mice / Myocardial disorders / Pancreatic elastase
105.	Ken Saito, 西岡義典, 佐藤浩充, 田村禎通, 仁木敏晴 and 森博愛 : Clinical characteristics of ventricular tachycardia, 心電図, Vol.3, No.5, 625-633, 1983. (Keyword) Holter心電図 / late-coupled VPC / 心室性頻拍症 / 突然死 / vulnerability index
106.	Ken Saito, 近藤千鶴子, 西岡義典, 田村禎通 and 森博愛 : Study of the sinus node function in active elderly subjects:Evaluation of diurnal variation of heart rate by ambulatory electrocardiography, 心臓, Vol.15, No.3, 307-315, 1983. (Keyword) 高年者 / Holter心電図 / arrhythmia / 心拍数変動値 / 洞機能
107.	Yoshiyuki Tamura, Morihiro Saito, Koji Matsumura, Ken Saito, Takashi Kudo, Katsuo Ishimaru, Toshiharu Niki and Hiroyoshi Mori : CYCLIC ADENOSINE 3',5'-MONOPHOSPHATE, ADENYL CYCLASE AND PHOSPHODIESTERASE IN THE CONDUCTION SYSTEM OF BOVINE HEART, Japanese Circulation Journal, Vol.47, No.3, 351-355, 1983. (Keyword) Cyclic AMP / Adenyl cyclase / Phosphodiesterase / Cardiac conduction system
108.	長瀬教夫, 田村禎通, 小林総一郎, 工藤隆, 宮上盛史, 佐光春信, Ken Saito, 仁木敏晴, 近藤一正 and 森博愛 : 自然発症糖尿病マウス(KKマウス)の心筋障害の成因に関する研究, Journal of Clinical and Experimental Medicine, Vol.124, No.3, 181-183, 1983.
109.	工藤隆, 田村禎通, 斎藤守弘, Ken Saito, 長瀬教夫, 小林総一郎, 宮上盛史, 佐光春信, 仁木敏晴 and 森博愛 : 心臓刺激伝導系(特殊心筋)のミオシンBの超沈澱およびATPase活性に関する研究, Journal of Clinical and Experimental Medicine, Vol.123, No.6, 667-669, 1982.
110.	Ken Saito, Yoshihiro Tamura, Morihiro Saito, Koji Matsumura, Toshiharu Niki and Hiroyoshi Mori : Comparison of Superprecipitation and Contractile Protein Contents of Myosin B in the Myocardium and Conduction System, Japanese Heart Journal, Vol.23, No.1, 105-112, 1982. (Keyword) Cardiac conduction system / Myosin B / Superprecipitation / Contractile protein content / Myosin light chain
111.	Ken Saito, 田村禎通, 斎藤守弘, 松村幸治, 仁木敏晴 and 森博愛 : 心臓刺激伝導系(特殊心筋)のミオシン各鎖の定量的検討, Journal of Clinical and Experimental Medicine, Vol.117, No.13, 1079-1080, 1981.
112.	Ken Saito, 田村禎通, 斎藤守弘, 松村幸治, 仁木敏晴 and 森博愛 : 心臓刺激伝導系(特殊心筋)のミオシンBの超沈澱現象に関する研究, Journal of Clinical and Experimental Medicine, Vol.117, No.11, 841-939, 1981.
113.	田村禎道, Ken Saito, 斉藤守弘, 松村幸治, 仁木敏晴, 森博愛 and 露口直彦 : Studies on myosin and Na+,K+-ATPase of the bovine cardiac conduction system, 心臓, Vol.13, No.4, 412-418, 1981.
114.	Ken Saito, Yoshiyuki Tamura, Morihiro Saito, Koji Matsumura, Toshiharu Niki and Hiroyoshi Mori : Comparison of the subunit compositions and ATPase activities of myosin in the myocardium and conduction system, Journal of Molecular and Cellular Cardiology, Vol.13, No.3, 311-322, 1981. (Keyword) Specialized heart muscle / Myosin / SDS-polyacrylamide gel electrophoresis / Light chain / molecular weight / Carboxymethylation / Myosin ATPase / Myosin isoenzyme (Link to Publication Site) ● Publication site (DOI): 10.1016/0022-2828(81)90319-9 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.1016/0022-2828(81)90319-9 (DOI: 10.1016/0022-2828(81)90319-9)
115.	Ken Saito and Yoshiyuki Tamura : Studies on characterization of contractile proteins of the cardiac conduction system of bovine heart, Shikoku Acta Medica, Vol.37, No.1, 31-41, 1981.
116.	仁木敏晴, Yutaka Nakaya, Ken Saito, 林博愛, 佐藤浩充, 三木延茂, 喜田正良, 横井良明 and 村山善紀 : 狭心症に対するニトログリセリン軟膏の使用経験, 基礎と臨床, Vol.15, No.1, 101-108, 1981.
117.	Ken Saito, 田村禎通, 斎藤守弘, 松村幸治, 仁木敏晴 and 森博愛 : 心臓刺激伝導系(特殊心筋)のmyosin light chainに関する研究, Journal of Clinical and Experimental Medicine, Vol.114, No.10, 859-861, 1980.
118.	横井良明, 仁木敏晴, 森博愛, 坂東重信, Ken Saito, 西岡義典, 井坂勝利, 寿満裕司, 鈴木英司, 坂東玲芳 and 太田重嘉 : 各種不整脈に対するdisopyramideの効果, The Japanese journal of clinical and experimental medicine, Vol.57, No.6, 233-237, 1980.
119.	Ken Saito, 松久茂久雄, 福田信夫, 西岡義典 and 仁木敏晴 : 先天性左心外膜部分欠損症の1例, Respiration & Circulation, Vol.27, No.4, 425-429, 1979.
120.	横井良明, 坂井秀樹, 松久茂久雄, 日浅芳一, 大木崇, 森博愛, Ken Saito, 福田信夫, 坂東重信 and 西岡義典 : 先天性左心膜欠損症の二例, The Japanese journal of clinical and experimental medicine, Vol.55, No.9, 195-199, 1978.

Academic Paper (Unrefereed Paper):

1.	F Kishi, Masahiro Nomura, M Yukinaka, Ken Saito, Yutaka Nakaya and Susumu Ito : Source localization of initial QRS vector in patients with idiopathic cardiomyopathy : Comparison with normal subjects and patients with anterior myocardial infarction., In Biomag 96, 475-478, 2000.
2.	Masahiro Nomura, 岸史子, 近藤幸, 由岐中道子, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya, 大中政治 and Hideki Matoba : 長時間運動後のエネルギー代謝におよぼす影響, Heart, Vol.29, No.Suppl 4, 19-21, 1997.
3.	Ken Saito : Analysis of heart rate variability and its clinical application by Holter ECG recordings, Bulletin of School of Medical Sciences, the University of Tokushima, Vol.4, 23-37, 1994. (Keyword) circadian rhythm / Holter ECG / heart rate variability / autonomic nervous function (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1572824501768264704 (CiNii: 1572824501768264704)
4.	Ken Saito, Youko Kani, Sachiko Ikuhara, Eiji Hosoi, Rie Kasai and Hayato Yano : Diagnostic accuracy of arrhythmias in semi-automatic analysis by Fukuda-Holter system(SCM-280), Bulletin of School of Medical Sciences, the University of Tokushima, Vol.2, 197-203, 1992. (Keyword) Holter ECG / automatic analysis / diagnostic accuracy of arrhythmias
5.	Ken Saito, Yoshiharu Fukuda, Tomohiko Kawano, Tomoyuki Uchida, Toshihiko Tominaga, Nobuo Fukuda, Takashi Oki and Hiroyoshi Mori : Diurnal variation of the QT intervals in idiopathic mitral valve prolapse, Journal of Cardiology. Supplement, Vol.18, 67-73, 1988. (Summary) Diurnal variation of QT intervals was analyzed using Holter monitoring for 44 patients with mitral valve prolapse (MVP), and the relationship between ECG changes and autonomic nervous dysfunction was assessed by measuring blood catecholamine during bicycle ergometer exercise and various autonomic functional tests. The following results were obtained. 1. The QT intervals in MVP patients had greater diurnal variations and the averaged QTc was in a high level all the time. 2. Positivity of the autonomic functional tests and the catecholamine level after exercise were significantly high in patients of MVP. 3. After catecholamine depletion by beta-blocking agent (carteolol: 15 mg a day, 5 to 12 months' duration), the variation of QTc became less marked. These data indicate the presence of autonomic dysfunction in patients of MVP. (Keyword) Mitral valve prolapse / QT interval / Diurnal variation (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 3256608 ● Search Scopus @ Elsevier (PMID): 3256608 (PubMed: 3256608)

Review, Commentary:

1.	Ken Saito : ホルター心電図をどう使い，どう活かすか, Heart View, Vol.11, No.4, 92-95, Apr. 2007.
2.	Ken Saito and Masahiro Nomura : Brugada syndrome and its treatment, Shikoku Acta Medica, Vol.59, No.4,5, 220-227, Oct. 2003. (Keyword) Brugada syndrome / Brugada-type ECG / autonomic imbalance / VF / sadden cardiac death (Tokushima University Institutional Repository) ● Metadata: 110619 (Tokushima University Institutional Repository: 110619)
3.	Masamichi Kuwajima, Kayoko Sone, Ken Saito and Fusae Abe : 糖尿病は動脈硬化の進展にどう影響するか動脈硬化の進展具合を見るのに有用な非侵襲的検査, PRACTICE, Vol.14, No.2, 146-151, Mar. 1997.
4.	森博愛, 沢田誠三, Masahiro Nomura, Ken Saito and 四宮秀美 : 心電図一例一話[222] ー外傷後に典型的Burgada型心電図を示した47歳男性ー, The Japanese journal of clinical and experimental medicine, Vol.73, No.7, 1622-1628, Jul. 1996.
5.	森博愛, 仁木敏晴, 森下智文 and Ken Saito : 心電図一例一話[219] ー筋脱力，高K血症心電図を示した高血圧症の70歳女性ー, The Japanese journal of clinical and experimental medicine, Vol.73, No.4, 934-940, Apr. 1996.
6.	森博愛, 澤田誠三, Masahiro Nomura, Ken Saito and 四宮秀美 : 外傷後に典型的Brugada型心電図を示した47歳の男性, The Japanese journal of clinical and experimental medicine, Vol.73, 1622-1628, 1996.
7.	三好宏和, Yutaka Nakaya, 岸史子, 高倉正裕, Masahiro Nomura and Ken Saito : 冠動脈平滑筋細胞Kチャンネルに対するCalcitonin Gene-related Peptide (CGRP)の作用, Ther Res, Vol.16, 762-766, 1995.
8.	Ken Saito and 森博愛 : 心拍変動の解析とその臨床応用, Japan Medical Journal, Vol.3688, 21-24, Dec. 1994.
9.	森博愛, 西条義昭, Ken Saito and 西岡義典 : 心電図一例一話[155] ー低K血症により特異な頻脈性不整脈が誘発された76歳女性ー, The Japanese journal of clinical and experimental medicine, Vol.67, No.12, 169-174, Dec. 1990.
10.	Ken Saito and 森博愛 : 心筋異常の診断と心電図, The Journal of Practical Pharmacy, Vol.41, No.3, 7-11, Mar. 1990.
11.	森博愛, 井内新 and Ken Saito : 心電図一例一話[139] ー深い陰性T波を示した45才男性の高度の低Ca血症例ー, The Japanese journal of clinical and experimental medicine, Vol.66, No.7, 202-205, Jul. 1989.
12.	森博愛, Ken Saito and 日浅芳一 : 心電図一例一話[137] ー無痛性心筋虚血発作の頻発を認めた狭心症67才男性ー, The Japanese journal of clinical and experimental medicine, Vol.66, No.5, 204-210, May 1989.
13.	Ken Saito and 森博愛 : 臨床検査Q&A(高齢者の負荷心電図について), Medical Technology, Vol.17, No.3, 316-317, Mar. 1989.
14.	Ken Saito and 森博愛 : 臨床検査Q&A(ホルター心電図のとり方について), Medical Technology, Vol.17, No.3, 315-316, Mar. 1989.
15.	Ken Saito and 森博愛 : 臨床検査Q&A(小児のECGでV4∼V6のP波陰性について), Medical Technology, Vol.17, No.1, 69-70, Jan. 1989.
16.	Ken Saito : 話題の機器インテリジェント化心電計マイコンの''知能''が自動解析, NIKKEI MEDICAL, Vol.1-4, 141-146, Apr. 1988. (Keyword) computer / 心電図自動診断 / 診断精度 / 読み直し(オーバーリード)
17.	森博愛, 板東重信, 橋口淑夫, 西条義昭 and Ken Saito : Torsade de pointes ー臨床と成因, 心臓ペーシング, Vol.4, No.13, 252-264, Mar. 1988. (Keyword) Atypical ventricular tachycardia / Polymorphous ventricular tachycardia / Transient ventricular fibrillation / Long-short ventricular sequence / Sudden death
18.	Ken Saito, 仁木敏晴 and 森博愛 : インテリジェント化心電計は実用上問題ないか(虚血性心疾患の診断), BME, Vol.1, No.1, 6-10, Jan. 1987.
19.	Ken Saito : ホルター心電図ー解析上の問題点と最近の進歩ー, 徳島県臨床衛生検査技師会誌, Vol.23, No.2, 53-59, May 1986.
20.	Ken Saito, 松山清志 and 森博愛 : 非持続性心室頻拍の臨床的意義, Japan Medical Journal, Vol.3231, 43-48, Mar. 1986.
21.	仁木敏晴, 清水伸子, 松山清志, Ken Saito and 森博愛 : 心筋症の診断(心電図), New Horizon for Medicine, Vol.16, 1831-1837, Aug. 1984.
22.	森博愛, Ken Saito and 西岡義典 : 心電図一例一話[69] ーTorsade de pointes心室頻拍を示した79才女性ー, The Japanese journal of clinical and experimental medicine, Vol.60, No.9, 181-184, Sep. 1983.
23.	近藤千鶴子, 森本真二, 安宅芳夫, 秋山恭介, Ken Saito and 西岡義典 : Holter Avionics Systemの有効性(第三報) ーSick Sinus Syndromeの症例を中心にー, 香川県医師会誌, Vol.36, No.1, 14-45, Jul. 1983.
24.	森博愛 and Ken Saito : 心電図一例一話[65] ー心悸亢進を訴えた60才女性ー, The Japanese journal of clinical and experimental medicine, Vol.60, No.5, 205-208, May 1983.
25.	田村禎通, 森博愛 and Ken Saito : 急性症状と初期診療ー不整脈·動悸ー, The Japanese journal of clinical and experimental medicine, Vol.59, No.1, 54-59, Jan. 1982.
26.	田村禎通, 松村幸治, Ken Saito, 斉藤守弘, 仁木敏晴, 森博愛 and 露口直彦 : 心臓刺激伝導性心筋の代謝特異性, Japan Medical Journal, Vol.2954, 43-47, Dec. 1980.
27.	近藤千鶴子, 坂井秀樹, 西岡義典 and Ken Saito : Holter Avionics Systemの有効性(第二報) ー狭心症様症状の臨床的検討ー, 香川県医師会誌, Vol.33, No.2, 29-44, Nov. 1980.
28.	森博愛, 田村禎通 and Ken Saito : 心不全, The Japanese journal of clinical and experimental medicine, Vol.56, No.10, 55-60, Oct. 1979.
29.	森博愛, 大木崇, 横井良明 and Ken Saito : 心電図一例一話[15] ー左胸痛を主訴とした51才女子ー, The Japanese journal of clinical and experimental medicine, Vol.56, No.3, 202-204, Mar. 1979.
30.	Ken Saito and 西岡義典 : Holter Avionics Systemの有効性, 香川県医師会誌, Vol.31, No.1, 13-38, Jul. 1978.

Proceeding of International Conference:

1.	Shoko Fuji, Miki Satoh, Asumi Atsuta, Asami Kishi, Hiroko Sato, Yuko Yasuhara, Tetsuya Tanioka, Rozzano De Castro Locsin and Ken Saito : Electrophysiological Evidence of the Effect of Intentional Communication as Caring Technique on the Autonomic Nervous Activity of Persons with Dementia, International Association for Human Caring 36th International Conference, New Orleans, May 2015.
2.	K Endo, Hirotsugu Yamada, Kenya Kusunose, S Nishio, N Tomita, J Miki, T Niki, Koji Yamaguchi, Kunihiko Koshiba, Yoshio Taketani, Takashi Iwase, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Ken Saito and Masataka Sata : N-3 Fatty Acids, IMT and CKD as Risk Factors in Coronary Artery Disease., 第74回日本循環器学会総会・学術集会, Mar. 2010.
3.	Masahiro Nomura, Kohzou Uehara, Kenji Harada, Eiko Uemura, Akiko Iga, Akiyoshi Nishikado, Ken Saito, Yutaka Nakaya and Susumu Ito : Impairment of gastrointestinal motility by nitrate administration: Evaluation based on electrogastrographic changes and autonomic nervous activities, 10th Taisyo international symposium on gastroenterology, Shimoda, Apr. 2003.
4.	Masahiro Nomura, Yutaka Nakaya, Hitoshi Miyajima, Tomomi Nada, Yoshie Ochi, Ritsuko Kawaguchi, S Morishita, Akiyoshi Nishikado, Hiroshi Shibata, Hirohito Honda, Ken Saito and Susumu Ito : Detection of myocardial damage caused by hepatitis C virus using signal averaged electrocardiogram and 123I-BMIPP myocardial scintigraphy, The XXVIII International congress on electrocardiology, Sao Paulo,Brazil, 2001.
5.	Michiko Yukinaka, Masahiro Nomura, Tomomi Nada, Yuki Kondo, Ken Saito, Susumu Ito and Yutaka Nakaya : QTc Dispersion using magnetocardiogram: Analysis in patients with myocardial infarction, The 11th International Conference on Biomagnetism, Sendai, 1998.
6.	Yuki Kondo, Masahiro Nomura, Tomomi Nada, Michiko Yukinaka, Ken Saito, Susumu Ito and Yutaka Nakaya : Biomagnetic measurement of small intestine electrical activity by 64-channel magnetographic imaging, The 11th International Conference on Biomagnetism, Sendai, 1998.
7.	Michiko Yukinaka, K Tezuka, Masahiro Nomura, Toru Hayashi, T Torisu, Y Takeuchi, Yuki Kondo, Ken Saito, Susumu Ito and Yutaka Nakaya : 1/f fluctuation of heart rate during colon fiberscopy, World Congresses of Gastroenterology, Wien, 1998.
8.	Yuki Kondo, Masahiro Nomura, Michiko Yukinaka, Tomomi Mitani, Ken Saito, Hirohito Honda, Ichiro Shimizu, Susumu Ito and Yutaka Nakaya : Myocardial injury on injections of interferon in patients with chronic hepatitis: assessment by myocardial scintigraphy, World Congresses of Gastroenterology, Wien, 1998.
9.	Yuki Kondo, Masahiro Nomura, Tomomi Mitani, Michiko Yukinaka, Ken Saito, Hirohito Honda, Ichiro Shimizu, Yutaka Nakaya and Susumu Ito : Clinical significance of 1/f fluctuation of 24-hour heart rate variability: studies in liver cirrhosis, The 11th Biannual scientific meeting Asian Pacific association for the study of liver, Perth, 1998.
10.	Michiko Yukinaka, Masahiro Nomura, Tomomi Mitani, Yuki Kondo, Ken Saito, Hirohito Honda, Ichiro Shimizu, Yutaka Nakaya and Susumu Ito : Production of nitric oxide and sympathetic nervous dysfunction in patients with liver cirrhosis, The 11th Biannual scientific meeting Asian Pacific association for the study of liver, Perth, 1998.
11.	Tomomi Mitani, Masahiro Nomura, Yuki Kondo, Michiko Yukinaka, Ken Saito, Hirohito Honda, Ichiro Shimizu, Yutaka Nakaya and Susumu Ito : Assessment of autonomic nervous activity in liver cirrhosis using blood pressure variability by tonometry, The 11th Biannual scientific meeting Asian Pacific association for the study of liver, Perth, 1998.
12.	Masahiro Nomura, Yuki Kondo, Tomomi Nada, Michiko Yukinaka, Ken Saito, Susumu Ito and Yutaka Nakaya : Biomagnetic measurement of small intestinal electrical activity by 64-channel magnetographic imaging, The 11th International Conference on Biomagnetism, Sendai, 1998.
13.	Yuki Kondo, Yutaka Nakaya, Masahiro Nomura, Michiko Yukinaka, Ken Saito and Susumu Ito : Clinical significance of 1/f fluctuation of 24-hour heart rate variability: studies in gastroenterological disease, The 6th United European Gastroenterology week, Birmingham, UK, 1997.
14.	Michiko Yukinaka, Masahiro Nomura, Yuki Kondo, Ken Saito, Yutaka Nakaya and Susumu Ito : Detection of sympathetic nervous dysfunction in patients with liver cirrhosis using 123I-metaiodobenzylguandine myocardial scintigraphy, The 6th United European Gastroenterology week, Birmingham, UK, 1997.
15.	Fumiko Kishi, Masahiro Nomura, Yutaka Nakaya, Ken Saito and Susumu Ito : Source localization of initial QRS vector in patients with idiopathic cardiomyopathy: comparison with normal subjects and patients with anterior myocardial infarction, The 10th International Conference on Biomagnetism, Santa Fe, New Mexico, USA, 1996.
16.	Michiko Yukinaka, Yutaka Nakaya, Masahiro Nomura and Ken Saito : Analysis of electromotive force by magnatocardiogram - Is the origin of initial QRS force (septal vector) intraventricular septum?, The 10th International Conference on Biomagnetism, Santa Fe, New Mexico, USA, 1996.
17.	Masahiro Nomura, Yutaka Nakaya, Fumiko Kishi, Michiko Yukinaka, Ken Saito, Hiroshi Shibata and Susumu Ito : Heart rate variability during painful medical procedures (percutaneous ethanol injection therapy), The XXIIIrd International congress on Electrocardiology, Cleveland, USA, 1996.
18.	Tetsuya Saijo, Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi, Ichiro Shimizu, Susumu Ito, H Moritoki, Y Shiraishi, H Mima, Takashi Yamamoto, Hirofumi Yamamoto and Shunsuke Orino : Circadian rhythm of autonomic nervous function in patients with hepatic encephalopathy, Annual Meetings of the American Gastroenterological Association and American Association for the Study Liver Diseases at Digestive Disease Week, San Francisco, 1996.
19.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi and Susumu Ito : Circadian profile of heart rate variability in mitral valve prolapse syndrome, XXI Internal Congress on Electrocardiology, Yokohama, 1994.
20.	Fumiko Kishi, Masahiro Nomura, Yutaka Nakaya, Ken Saito and Susumu Ito : Relationship between the ischemic myocardium and focus of ventricular tachycardia in old myocardial infarction, XXI Internal Congress on Electrocardiology, Yokohama, 1994.
21.	Tetsuya Saijyo, Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi and Susumu Ito : Time- and frequency-domain heart rate variability in patients with liver cirrhosis, XXI Internal Congress on Electrocardiology, Yokohama, 1994.
22.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi, Susumu Ito, M Yoshizui, Itsuo Katoh, T Ohuchi and M Oka : Free and conjugated catecholamines before and after exercise in mitral valve prolapse, First World Congress on Stress, Bethesda, USA, 1994.
23.	Tetsuya Saijyo, Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi, Hirohito Honda, Ichiro Shimizu and Susumu Ito : Autonomic function during upper gastrointestinal endoscopy using blood pressure measurement by tonometry, First World Congress on Stress, Bethesda, USA, 1994.
24.	Hirokazu Miyoshi, Fumiko Kishi, K Watanabe, Masahiro Nomura, Ken Saito and Yutaka Nakaya : Nonendothelial-derived nitric oxide activates the K+ channels in cultured vascular smooth muscle cells, Tokyo Women's Medical international Symposium '94, Tokyo, 1994.
25.	Hirokazu Miyoshi, Fumiko Kishi, Masahiro Nomura, Ken Saito and Yutaka Nakaya : Muscle-derived nitric oxide produced greater vasodilative action than nitrovasolators, XIth Scientific Sessions of International Society for Heart Research Japanese Section, Tokyo, 1994.
26.	Tetsuya Saijo, Susumu Ito, Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi, H Fujikawa, W Shinohara, S Ohkita and Shunsuke Orino : Heart rate variability in peptic ulcer, The 95th Annual Meetings of the American Gastroenterological Association, New Orleans, 1994.
27.	Masahiro Nomura, Tetsuya Saijyo, Yutaka Nakaya, Ken Saito, Fumiko Kishi and Susumu Ito : Autonomic imbalance in liver cirrhosis, The 95th Annual Meetings of the American Gastroenterological Association, New Orleans, 1994.
28.	Tetsuya Saijo, Masahiro Nomura, Yutaka Nakaya, Fumiko Kishi, Ken Saito and Susumu Ito : Decreased variability of arterial blood pressure in patients with liver cirrhosis, The 10th World Congress of Gastroenterology, Los Angeles, 1994.
29.	Tetsuya Saijo, Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi, Susumu Ito, H Shinohara, H Yamamoto and Shunsuke Orino : Autonomic nervous imbalance during colon fiberscopy, 10th World Congress of Gastroenterology, Los Angeles, 1994.
30.	Masahiro Nomura, Tetsuya Saijyo, Yutaka Nakaya, Ken Saito, Shunsuke Orino and Susumu Ito : The autonomic factor in occurence of peptic ulcer associated with essential hypertension, The 10th World Congress of Gastroenterology, Los Angeles, 1994.
31.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi, Hirokazu Miyoshi, Susumu Ito, Masao Wada, Satoshi Fujita, Tsutomu Takae and Itsuro Tamura : Atrial excitation onto the MRI using magnetocardiogram, The 9th International Conference on Biomagnetism, Wien, 1993.
32.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi, Hirokazu Miyoshi, Susumu Ito, Masao Wada, Satoshi Fujita, Tsutomu Takae and Itsuro Tamura : Localization of the focus in ventricular tachycardia by magnetocardiogram, The 9th International Conference on Biomagnetism, Wien, 1993.
33.	Yutaka Nakaya, Masahiro Nomura, Ken Saito, F Kishi, Hirokazu Miyoshi, Akiyoshi Nishikado, Shigenobu Bando and Hiromu Nishitani : Comparative studies of magnetocardiographic and electrocardiographic mappings for localization of accessory pathway in WPW syndrome, The 9th International Conference on Biomagnetism, Wien, 1993.
34.	Ken Saito, Yutaka Nakaya, Masahiro Nomura, N Takeuchi, Naoki Muguruma, Fumiko Kishi, Hirokazu Miyoshi and Hiromu Nishitani : Study on the excitation process during ventricular depolarization in normal subjects by magnetocardiogram, The 9th International Conference on Biomagnetism, Wien, 1993.
35.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, I Tamura, M Wada, S Fujita and T Takae : Localization of early ventricular depolarization by magnetocardiogram in patients with WPW syndrome and ventricular tachycardia, American College of Cardiology 42nd Annual Scientific Session, Anaheim, 1993.
36.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, Fumiko Kishi, Masao Wada, S Fujita, T Takae and I Tamura : Source localization of atrial excitation by three-dimensional magnetocardiographic imaging, American Heart Association 66th Scientific Sessions, Atlanta, 1993.
37.	Tetsuzo Wakatsuki, Yutaka Nakaya, Yukiko Miyoshi, XR Zeng, Masahiro Nomura, Ken Saito and Isao Inoue : Effect of vasopressin ATP-sensitive and Ca²⁺-activated K⁺ channels of coronary arterial smooth muscle cell, International Symposium "smooth muscle" -Assessment of current knowledges-, Fukuoka, 1992.
38.	Yukiko Miyoshi, Tetsuzo Wakatsuki, Masahiro Nomura, Ken Saito, Yutaka Nakaya and Isao Inoue : Endothelin blocks ATP-sensitive K+ channels and depolarizes smooth muscle cells of porcine artery, International Symposium "smooth muscle" -Assessment of current knowledges-, Fukuoka, 1992.

Proceeding of Domestic Conference:

1.	Hiroko Sugimoto, Yuko Yasuhara, Tetsuya Tanioka, Ken Saito, 小笠原坦, 長尾恵子 and 三船和史 : 集団療法により自律神経活動に変化がみられた認知症高齢者の1 事例, 第40回中国・四国精神保健学会, Nov. 2016.
2.	鈴川理之, Takakazu Kinugawa, Mai Matsumoto, Yuki Horike, Yurie Tamai, Susumu Nishio, Yukina Hirata, Hirotsugu Yamada, Kenya Kusunose, Masataka Sata and Ken Saito : 前負荷増大に対する右心系の反応性ー下肢陽圧負荷を用いた若年健常者における検討, 徳島県臨床検査技師会誌, 23, Dec. 2014. (Keyword) 下肢陽圧試験 / 前負荷増大 / 心筋ストレイン値
3.	Mai Matsumoto, Takakazu Kinugawa, Ken Saito, Yurie Tamai, Yuki Horike, Aya Matsura and Akiko Sakurai : 若年健常者におけるTpTeの分布と性差に関する検討, 徳島県臨床検査技師会誌, 22, Dec. 2014. (Keyword) TpTe間隔 / 心拍変動解析 / 自律神経機能
4.	Takakazu Kinugawa, Mai Matsumoto, Ken Saito, Yurie Tamai, Yuki Horike, Aya Matsura and Akiko Sakurai : 自己回帰モデルを用いた短時間心拍変動解析の検討, 徳島県臨床検査技師会誌, 21, Dec. 2014. (Keyword) 自己回帰モデル / 心拍変動解析 / 自律神経機能
5.	堀家由貴, Hirotsugu Yamada, 玉井佑里恵, 平田有紀奈, 鳥居祐太, 天野里江, 西尾進, 山尾雅美, 高川由利子, Mika Bando, 林修司, Kenya Kusunose, 宮崎達志, 足立克仁, Masataka Sata and Ken Saito : 左室収縮不全に対する薬物療法によってDuchenne型筋ジストロフィーの予後は改善したか, 第105回日本循環器学会四国地方会, Dec. 2014.
6.	堀家由貴, Hirotsugu Yamada, 西尾進, Junko Hotsuchi, 林修司, 玉井佑里恵, 宮崎達志, 足立克人, Ken Saito and Masataka Sata : Duchenne 型筋ジストロフィーにおける左心機能の経年変化, 第87回日本超音波医学会学術集会, May 2014.
7.	Mami Kawamura, Eri Ishikawa, Ken Saito, Tatsuaki Tomofuji, Yuki Horike and Yurie Tamai : ホルター心電図を用いたTpTe間隔のサーカディアンリズムと自律神経機能に関する検討, 徳島県臨床検査技師会誌, 22, Dec. 2013.
8.	Eri Ishikawa, Mami Kawamura, Ken Saito, Tatsuaki Tomofuji, Yurie Tamai and Yuki Horike : ホルター心電図を用いたTpTe間隔の心拍依存性に関する検討, 徳島県医学検査学会誌, 21, Dec. 2013.
9.	D Hirota, Hirotsugu Yamada, S Nishio, Y Hirata, R Tamai, M Nakagawa, S Hayashi, J Hotchi, Masataka Sata and Ken Saito : 当院で経験した大動脈二尖弁の特徴, 第22回日本超音波医学会四国地方会学術集会，第11回四国地方会講習会, Oct. 2012.
10.	D Hirota, Hirotsugu Yamada, S Nishio, Y Hirata, R Tamai, M Nakagawa, Mika Bando, J Hotchi, S Hayashi, N Tomita, M Sata and Ken Saito : 健常日本人の三尖弁輪運動速波形および三尖弁輪収縮期移動距離における加齢および性差の影響, 第60回日本心臓病学会学術集会, Sep. 2012.
11.	弘田大智, 西尾進, Mika Bando, 冨田紀子, 發知淳子, 林修司, 中川摩耶, 平田有紀奈, Takashi Iwase, Hirotsugu Yamada, Ken Saito and Masataka Sata : 右室自由壁の著名な肥厚を認めた右室心筋脂肪浸潤の1例, 第37回日本超音波検査学会学術集会, Jun. 2012.
12.	D Hirota, Hirotsugu Yamada, S Nishio, Y Hirata, M Nakgawa, Mika Bando, J Hotchi, N Tomita, Masataka Sata and Ken Saito : ボセンタン投与により肺動脈性肺高血圧症合併妊娠の転機が改善した一例, 日本超音波医学会第85回学術集会, May 2012.
13.	D Hirota, S Nishio, Mika Bando, N Tomita, J Hotchi, S Hayashi, M Nakagawa, R Tamai, Y Hirata, Takashi Iwase, Yoshio Taketani, Hirotsugu Yamada, Ken Saito and Masataka Sata : 右室自由壁の著明な肥厚を認めた右室心筋脂肪浸潤の1例, 第23回日本心エコー図学会学術集会, Apr. 2012.
14.	弘田大智, 西尾進, Hirotsugu Yamada, 遠藤桂輔, 冨田紀子, 林修司, 平田有紀奈, 玉井利奈, 中川摩耶, Masataka Sata and Ken Saito : 陳旧性心筋梗塞におけるV1誘導のP波と左房負荷:心エコー・ドプラ法を用いた検討, The 76th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2012.
15.	Sakiko Doi, Chieko Matsuura and Ken Saito : 冷え性と肩こりに関する検討, 徳島県臨床検査技師会誌, 29, Dec. 2011.
16.	Tatsuaki Tomofuji, Aya Matsura, Ken Saito and 弘田大智 : デジタルホルター心電計によるQT間隔日内変動様式の検討, 徳島県臨床検査技師会誌, 32, Dec. 2011.
17.	Tatsunori Inagaki, Tatsuaki Tomofuji, Ken Saito, 吉川陽子, 鳥海進一 and 矢野勇人 : 心筋梗塞発症時Tombstone様ST上昇を認めたWellens症候群の1例, 徳島県臨床検査技師会誌, 31, Dec. 2011.
18.	Aya Matsura, Tatsunori Inagaki, Ken Saito, 佐藤光代, Hirotsugu Yamada, 吉川陽子 and 矢野勇人 : 心サルコイドーシスに於けるfragmented QRS(fQRS)の出現頻度とその臨床的意義, 徳島県臨床検査技師会誌, 30, Dec. 2011.
19.	元野睦美, 山崎優, Ken Saito, 吉川陽子 and 矢野勇人 : 冠攣縮性狭心症における虚血性J波の出現様式に関する検討, 第34回徳島県医学検査学会, Dec. 2010.
20.	山崎優, 元野睦美 and Ken Saito : 若年健常者における不整脈基質の変遷, 第34回徳島県医学検査学会, Dec. 2010.
21.	辻本麻愉, 間宮真奈美 and Ken Saito : 職場検診例に於ける早期再分極の出現頻度とその特徴, 第34回徳島県医学検査学会, Dec. 2010.
22.	間宮真奈美, 辻本麻愉, Ken Saito and 遠藤桂輔 : 無線ヘッドホンを用いた心音・心機図検査装置の使用経験, 第34回徳島県医学検査学会, Dec. 2010.
23.	遠藤桂輔, Hirotsugu Yamada, Kenya Kusunose, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Ken Saito and Masataka Sata : EPA/AA比は冠動脈疾患の重症度に相関する:徳島大学病院循環器内科データベースを用いた検討, 第58回日本心臓病学会学術集会, Sep. 2010.
24.	佐藤光代, 平岡葉月, 山本良, Yasunori Nagamine, Kazuko Shono, Toshio Doi, Hirotsugu Yamada and Ken Saito : 特異な心電図所見を呈した肥大型心筋症の親子例, 第59回日本医学検査学会, May 2010.
25.	遠藤桂輔, Hirotsugu Yamada, 西尾進, 冨田紀子, Kenya Kusunose, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Masataka Sata and Ken Saito : リアルタイム3次元経食道エコー法により観察しえた孤立性僧帽弁クレフトの1例, 第21回日本心エコー図学会学術集会, May 2010.
26.	遠藤桂輔, Ken Saito, Hirotsugu Yamada, Kenya Kusunose, 冨田紀子, 多田津陽子, Takeshi Soeki, Masataka Sata, 西尾進, 佐藤光代, 平岡葉月, 河野裕美 and 三木淳子 : 心エコー図検査で偶然発見された乳頭状線維弾性腫の2例, 日本超音波医学会四国地方会, Dec. 2009.
27.	矢野尚三郎, 平岡葉月, 山本良, 佐藤光代, Kazuko Shono, Yasunori Nagamine and Ken Saito : 12誘導ホルター心電図検査の有用性, 第33回徳島県医学検査学会, Dec. 2009.
28.	浦山みどり, 溝口佳緒里, Ken Saito and 遠藤桂輔 : Brugada型心電図自動診断の診断精度に関する検討, 第33回徳島県医学検査学会, Dec. 2009.
29.	溝口佳緒里, 浦山みどり, Ken Saito, 佐藤光代 and Hirotsugu Yamada : 心サルコイドーシスの心電図的特徴―サルコイドーシスとの比較―, 第33回徳島県医学検査学会, Dec. 2009.
30.	吉本恵, 佐藤美咲, 門脇芽里, Ken Saito and Yutaka Nakaya : 血管超音波検査法による血管内皮機能の検討, 第30回徳島医学検査学会, Dec. 2006.
31.	門脇芽里, 佐藤美咲, 吉本恵, Ken Saito, 吉川陽子 and 矢野勇人 : 非持続性心室頻拍の治療経過中に突然死した肥大型心筋症の1例, 第30回徳島県医学検査学会, Dec. 2006.
32.	新谷保実, 日浅芳一, 大櫛日出郷, 田村克也, 長瀬教夫, 西内健, 福島泰江, Ken Saito, 藤中雄一, 松下隆哉 and 西村典三 : 徳島高血圧・糖尿病study第2報, 徳島医学会第232回学術集会, Feb. 2006.
33.	Masahiro Nomura, Yutaka Nakaya, 宮島等, 名田智美, Ken Saito and Susumu Ito : 心磁図法を用いた心臓異常所見の検出:心電図法で捉えられない心起電力を検出できるか?(シンポジウム), 第15回日本生体磁気学会大会, 2000.
34.	Hiroshi Bandou, Shiro Saito, 島健二, Mitsuo Itakura, Masamichi Kuwajima, Ken Saito, Haruhiko Saito, 小松まち子, 長瀬教夫, 亀山和人, 西村典三, 中西嘉巳, 山野利尚, 山崎正行, 滝下佳寛, 米田和夫, 小原卓爾, 野間善彦, Katsuhiko Yoshimoto, 矢木文和, 吉田健三, 増田和彦, 折野和人, 市川和佳 and 中矢修一郎 : 徳島県における糖尿病患者の現状, 日本糖尿病学会中国四国地方会第34回総会(宇部), Oct. 1996.
35.	西條哲也, Masahiro Nomura, Ken Saito and Susumu Ito : 消化性潰瘍の病態生理と臨床，(シンポジウム)消化性潰瘍例の心拍スペクトル解析による自律神経機能の検討, 第30回日本臨床生理学会, 1993.
36.	Yoshiyuki Tamura and Ken Saito : 特殊心筋の代謝特異性, 第19回日本臨床生理学会総会, Jun. 1982.

Et cetera, Workshop:

1.	遠藤桂輔, Hirotsugu Yamada, Kenya Kusunose, 西尾進, 冨田紀子, 三木淳子, 林修司, 玉井利奈, 河野裕美, 平岡葉月, 佐藤光代, Koji Yamaguchi, Takashi Iwase, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Ken Saito and Masataka Sata : 陳旧性心筋梗塞症における心電図左房負荷所見の意義:心エコー・ドプラ法を用いた検討, 心・血管クラスターミニリトリート, Jan. 2011.
2.	遠藤桂輔, Hirotsugu Yamada, 西尾進, 冨田紀子, Kenya Kusunose, 林修司, 佐藤光代, 平岡葉月, 河野裕美, 三木淳子, 玉井利奈, Koji Yamaguchi, Yoshio Taketani, Takeshi Soeki, Tetsuzo Wakatsuki, Masashi Akaike, Masataka Sata and Ken Saito : 心電図異常を指摘され，心エコー検査で発見された左室緻密化障害の1例, 第3回蔵本エコーカンファレンス, Jul. 2010.
3.	Miwa Furuta, Yumi Uemura, Akiko Hiya, Ken Saito, Youko Yoshikawa, Taku Fujimoto and Hayato Yano : 高血圧症におけるLV strainのベスト·アプリケーション, 第29回徳島県医学検査学会, Dec. 2005.
4.	Akiko Hiya, Yumi Uemura, Miwa Furuta, Ken Saito and Chieko Matsuura : ストレスマーカーとしての心拍変動解析の意義, 第29回徳島県医学検査学会, Dec. 2005.
5.	Masahiro Nomura, Yutaka Nakaya, Tomohito Kawano, Kimiko Nakayasu and Ken Saito : 心磁図法による心筋梗塞ベクトルの評価, 第22回日本心電学会学術集会, Oct. 2005.
6.	Masahiro Nomura, Tomohito Kawano, Kunihiko Koshiba, Koji Yamaguti, Tomonori Watanabe, 福田大和, Takeshi Soeki, Ken Saito, Yutaka Nakaya and Kimiko Nakayasu : 平均心拍数および血圧と冠動脈病変の評価, 第53回日本心臓病学会学術集会, Sep. 2005.
7.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, Tomohito Kawano and Akiyoshi Nishikado : 心磁図法を用いた本態性高血圧症における心室再分極異常の早期診断, 第21回日本心電学会学術集会, Sep. 2004. (Summary) 正常電流以外にみられる左前胸部下方のcurrent densityは，高血圧性心筋障害によりもたされた心筋障害ベクトルであると考えられた．
8.	Masahiro Nomura, Akiko Iga, Akiyoshi Nishikado, Ken Saito, Takashi Oki, Susumu Ito and Yutaka Nakaya : Evaluation of coronary microvascular disorder using 99mTc-MIBI myocardial SPECT, 66th annual scientific meeting of the Japanese Circulation society, Apr. 2004. (Summary) 冠動脈造影にて有意狭窄がないが，運動負荷にてST低下を示す例について，99mTc-MIBI心筋シンチにて冠動脈予備能は低下していた．
9.	Masahiro Nomura, Yutaka Nakaya, Akiko Iga, Akiyoshi Nishikado, Ken Saito, Takashi Oki and Susumu Ito : Detection of electrical conduction velocity using 32-channel high temperature superconducting quantum interference device, 66th annual scientific meeting of the Japanese Circulation society, Apr. 2004. (Summary) 32チャンネル高温SQUIDを用いて，電流源を推定して，心室の電流伝播速度を計算した．Durrerらの報告とほぼ一致し，本装置の臨床的有用性が示唆された．
10.	Masahiro Nomura, Akiko Iga, Akiyoshi Nishikado, Ken Saito, Takashi Oki, Susumu Ito and Yutaka Nakaya : Relation between insulin resistance and 123I-BMIPP myocardial scintigraphy, 66th annual scientific meeting of the Japanese Circulation society, Apr. 2004. (Summary) インスリン抵抗性と123I-BMIPP心筋シンチグラフィ所見と関連を検討し，HOMA-RとBMIPP洗い出し率は有意な負の相関関係がみられた．
11.	Kouji Yamaguchi, Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, Eiji Tanaka, Tomohito Kawano, Kanji Kusunoki, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Junji Yamashita, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito : Effect of CPAP therapy in hypertensive patients with obstructive sleep apnea: Analysis of automonic activity, adhesion molecules and inflammatory signs, The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004. (Summary) CPAP治療は，自律神経活動，血管接着因子および炎症性サインを低下させ，高血圧合併のOSASの心血管および脳血管障害を軽減させると考えられた．
12.	Tomohito Kawano, Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, H Tanaka, Kanji Kusunoki, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Junji Yamashita, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito : The anti-atherosclerosis effect of glimepiride: Examination by inflammatory cytokines, pulse wave velocity (baPWV) and agumentation index (AI), The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004. (Summary) グリメピリドはアディポネクチンを増加しTNF-αを低下させ，インスリン抵抗性を改善し，炎症性サイトカインを抑制すし抗動脈硬化的に作用した．
13.	Tomohito Kawano, Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, H Tanaka, Kanji Kusunoki, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Junji Yamashita, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito : Electrophysiological improvement of the atrium by losartan potassium (Nu-Lotan®) in hypertensive patients., The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004. (Summary) ニューロタン®における心房興奮を平均加算化心電図を用いて電気的興奮における作用について検討し，心房における電気生理的改善効果が期待された．
14.	Junji Yamashita, Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, H Tanaka, Kanji Kusunoki, Tomohito Kawano, Kouji Yamaguchi, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito : Mechanism of ST segment depression during exercise test in patients with liver cirrhosis., The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004. (Summary) 肝硬変症で増加する女性ホルモンはジギタリスに類似し，冠動脈微小動脈の収縮作用のため，冠動脈に有意狭窄がなくとも運動負荷時にST低下をきたす．
15.	Masahiro Nomura, Akiyoshi Nishikado, Tomotsugu Tabata, Tetsuzo Wakatsuki, H Tanaka, Kanji Kusunoki, Tomohito Kawano, Norihito Kageyama, Eriko Kimura, Shinichiro Miyazaki, Junji Yamashita, Eiko Uemura, Susumu Ito, Yutaka Nakaya and Ken Saito : Current density map in ventricular repolarization phase in diabetic patients., The 68th Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2004. (Summary) 糖尿病例の心室再分極異常について検討した．Current density mapにより，心電図で検出される前の異常を早期に検出できると思われた．
16.	Kazumi Nemoto, Ai Matsumoto, Ken Saito, Youko Yoshikawa, Fujimoto Taku and Yano Hayato : 脈波伝播速度による動脈硬化諸要因の検討, 第28回徳島県医学検査学会, Dec. 2003.
17.	Ai Matsumoto, Kazumi Nemoto, Atsuko Nishimura, Ken Saito, Chieko Matsuura and Momose Keizo : 検診例における左脚前枝ブロック(LAFB)の出現頻度と基礎疾患, 第28回徳島県医学検査学会, Dec. 2003.
18.	Kazumi Nemoto, Ai Matsumoto, Ken Saito, Youko Yoshikawa, Fujimoto Taku and Yano Hayato : 脈波伝播速度による動脈硬化諸要因の検討, 第28回徳島県医学検査学会, Dec. 2003.
19.	林亨, 仁木美也子, 板東玄太郎, 安田貢, 鹿児島彰, 井上博之, 坂下修, 槙いずみ, 高橋義典, 山ノ井昭, 鳥巣隆資, 竹内義員, Ken Saito, Masahiro Nomura and Susumu Ito : 胃X線検査時の自律神経活動の変動バリウム，発泡剤投与及び頭低位時の比較検討, DDW-Japan 2003, Oct. 2003. (Summary) 胃X線検査時に，バリウム，発泡剤投与及び頭低位が行われるが，その際にはの自律神経活動が変動するため，心合併症に注意する必要がある．
20.	Masahiro Nomura, Yutaka Nakaya, 上村英子, 伊賀彰子, 澤優子, 蔭山徳人, 斎藤彰浩, Tomohito Kawano, 楠完治, 木村恵理子, 田中英二, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado and Ken Saito : 糖尿病における心筋障害の早期検出心磁図current density mapによる評価, 第51回日本心臓病学会学術集会, Sep. 2003. (Summary) 心磁図により糖尿病性心筋障害の早期診断が可能かどうか，current density mapにより検討した．異常電流が心電図で捉えられる以前に早期に検出できた．
21.	Masahiro Nomura, 上村英子, Yutaka Nakaya, 伊賀彰子, 蔭山徳人, 斎藤彰浩, Tomohito Kawano, 楠完治, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado and Ken Saito : ストレス下における自律神経及びQT dispersionの変動内視鏡下総胆管処置中の検討, 第51回日本心臓病学会学術集会, Sep. 2003. (Summary) 内視鏡下総胆管処置中には自律神経活動のアンバランスとQT dispersionの増大がみられるため，偶発症にまで進展する可能性が示唆された．
22.	楠完治, Masahiro Nomura, 蔭山徳人, 木村恵理子, 斎藤彰浩, Tomohito Kawano, 田中英治, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Yutaka Nakaya and Ken Saito : 閉塞性睡眠時無呼吸と動脈硬化との関連性脈波伝播速度(PWV)による検討, 第51回日本心臓病学会学術集会, Sep. 2003. (Summary) 動脈硬化に対して多変量解析では，OSASの存在が独立した危険因子であり，relative riskも高かった．OSASは独立して動脈硬化の進展と関連性がある．
23.	Tomohito Kawano, Masahiro Nomura, 蔭山徳人, 斎藤彰浩, 楠完治, 木村恵理子, 田中英治, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Yutaka Nakaya and Ken Saito : 高齢者における胸部痛に対する硝酸薬の投与の影響, 第51回日本心臓病学会学術集会, Sep. 2003. (Summary) 高齢者の胸痛患者はGERDの場合がある．亜硝酸薬は胃運動の低下，副交感神経の低下と交感神経の増加をきたし，消化管運動を抑制し症状を増悪させる．
24.	山下潤司, Masahiro Nomura, 森下智文, 武市直樹, 蔭山徳人, Tomohito Kawano, 楠完治, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Yutaka Nakaya and Ken Saito : 肝硬変症における運動負荷試験偽陽性の成因, 第51回日本心臓病学会学術集会, Sep. 2003. (Summary) 肝硬変症で増加する女性ホルモンはジギタリスに類似し，冠動脈微小動脈の収縮作用のため，冠動脈に有意狭窄がなくとも運動負荷時にST低下をきたす．
25.	Tomohito Kawano, Masahiro Nomura, 蔭山徳人, 斎藤彰浩, 楠完治, 木村恵理子, 田中英治, Tetsuzo Wakatsuki, Tomotsugu Tabata, Akiyoshi Nishikado, Yutaka Nakaya and Ken Saito : グリメピリドの動脈硬化抑制効果サイトカイン及び脈波伝播速度による検討, 第51回日本心臓病学会学術集会, Sep. 2003. (Summary) グリメピリドはTNF-αを低下させ，血管内皮障害やミトコンドリア障害を改善させ，血管の炎症の消退により動脈硬化が抑制されると考えられた．
26.	Kanji Kusunoki, Kohzou Uehara, Masahiro Nomura, Akiyoshi Nishikado, K Harada, N Kageyama, Yutaka Nakaya, Ken Saito, Tetsuzo Wakatsuki, Tomotsugu Tabata and Susumu Ito : Detection of myocardial microvasular disorders using dynamic 99mTc-MIBI SPECT., 67th annual scientific meeting of the Japanese Circulation society, Mar. 2003. (Summary) 糖尿病性微小循環障害例を用いて検討した．心筋微小循環障害は，99mTc-MIBIダイナミックSPECTのtime activity curveで検出されると考えられた．
27.	Kozo Uehara, Masahiro Nomura, Akiyoshi Nishikado, Kenji Harada, Kanji Kusunoki, N Kageyama, Yutaka Nakaya, Ken Saito, Tetsuzo Wakatsuki, Tomotsugu Tabata and Susumu Ito : Relationship among high-sensitive CRP, maximum oxygen uptake and insulin resistance., 67th annual scientific meeting of the Japanese Circulation society, Mar. 2003. (Summary) 高血圧症に閉塞性睡眠時無呼吸(SAS)が合併すると，交感神経活性がさらに亢進して，動脈硬化や高血圧がさらに進行する可能性があると思われた．
28.	N Kageyama, Kohzou Uehara, Masahiro Nomura, Akiyoshi Nishikado, K Harada, K Kusunoki, Tetsuzo Wakatsuki, Tomotsugu Tabata, Ken Saito, Yutaka Nakaya and Susumu Ito : Influence of sleep apnea on autonomic nervous activity in patients with essential hypertension, 67th annual scientific meeting of the Japanese Circulation society, Mar. 2003. (Summary) 高血圧症に閉塞性睡眠時無呼吸(SAS)が合併すると，交感神経活性がさらに亢進して，動脈硬化や高血圧がさらに進行する可能性があると思われた．
29.	林亨, 仁木美也子, 板東玄太郎, 安田貢, 鹿児島彰, 井上博之, 高橋義典, 山之井昭, 鳥巣隆資, 坂下修, 竹内義員, Ken Saito, Masahiro Nomura and Susumu Ito : 胃X線検査時における頭低時の自律神経活動の変動―心拍変動解析による検討, 日本集団検診学会, Feb. 2003. (Summary) 胃X線検査時における頭低時の自律神経活動の変動を心拍変動解析で検討した．検査中の副交感神経の抑制がみられ，循環動態の変化に注意が必要である．
30.	Masahiro Nomura, 伊賀彰子, Hirohito Honda, Ichiro Shimizu, Susumu Ito, Ken Saito and Yutaka Nakaya : 高齢者の非心臓性胸痛に対するニトロ製剤の是非:硝酸薬投与による胃運動と自律神経活動の検討, 第4回日本高齢者消化器医学会議, Jan. 2002. (Summary) 高齢者の非心臓性胸痛に対してニトロ製剤が使用されるが，硝酸薬は胃運動を低下させ，交感神経を亢進させ，GERDが臓悪することも考えられる．
31.	林亨, 青木利佳, 板東玄太郎, 安田貢, 鹿児島彰, 井上博之, 坂下修, 高橋義典, 山ノ井昭, 鳥巣隆資, Masahiro Nomura, Susumu Ito and Ken Saito : 胃X線検査時の自律神経活動の評価―心拍変動解析による検討, DDW-Japan 2001, Oct. 2001. (Summary) 胃X線検査時の自律神経活動を心拍変動解析により検討した．検査中に副交感神経の抑制がみられ，発泡剤による胃伸展が原因と考えられた．
32.	Masahiro Nomura, Yutaka Nakaya, 伊賀彰子, Akiyoshi Nishikado and Ken Saito : 32チャンネル高温超伝導量子干渉計による心起電力計測, 第18回日本心電学会学術集会, Oct. 2001. (Summary) 高温超伝導量子干渉計を用いて心起電力の検出が可能かどうか検討した．，signal/noise比も良好な波形を得ることができ，今後の臨床応用が期待される．
33.	森下智文, Masahiro Nomura, 山下潤司, 武市直樹, Akiyoshi Nishikado, Ken Saito, 大木崇 and Yutaka Nakaya : 99mTc-MIBIシンチグラフィを用いたC型ウイルス肝炎における心筋障害の検出, 第49回日本心臓病学会学術集会, Sep. 2001. (Summary) C型ウイルス肝炎において，99mTc-MIBIシンチを行い，洗い出し率を検討した．洗い出しの亢進がみられ，ミトコンドリア機能の障害が考えられた．
34.	Masahiro Nomura, Akiyoshi Nishikado, Ken Saito, 大木崇 and Yutaka Nakaya : 123I-BMIPP心筋シンチ画像と呼吸商との関連性, 第49回日本心臓病学会学術集会, Sep. 2001. (Summary) 呼吸商と123I-BMIPP心筋シンチでの脂肪酸代謝を比較した．心筋エネルギー代謝においても呼吸商が脂肪酸代謝に影響することが示唆された．
35.	Masahiro Nomura, Akiyoshi Nishikado, Ken Saito, 大木崇 and Yutaka Nakaya : カンデサルタンの左室拡張能，自律神経機能および最大酸素摂取量におよぼす影響, 第49回日本心臓病学会学術集会, Sep. 2001. (Summary) 呼気ガス，心筋シンチおよび心拍変動解析よりカンデサルタンの左室拡張能，自律神経機能および最大酸素摂取量を検討して，全パラメータは改善した．
36.	Masahiro Nomura, Akiyoshi Nishikado, Ken Saito, 大木崇 and Yutaka Nakaya : トータル·ヘルス·プロモーション·プランニングの運動処方によるインスリン抵抗性および最大酸素摂取量への効果, 第49回日本心臓病学会学術集会, Sep. 2001. (Summary) THPの運動処方により，インスリン抵抗性および最大酸素摂取量が増加し，労働者の運動習慣の重要性が明らかにされた．
37.	Masahiro Nomura, Akiyoshi Nishikado, Ken Saito, 大木崇 and Yutaka Nakaya : 32チャンネル高温超伝導量子干渉計を用いた心臓dipoleの三次元伝播過程の同定, 第49回日本心臓病学会学術集会, Sep. 2001. (Summary) 32チャンネル高温超伝導量子干渉計を用いて心臓dipoleの三次元伝播過程の同定を行い，心電図同期MRI画像上にマッピングした．
38.	Masahiro Nomura, 伊賀彰子, 名田智美, 日浅亜弥, 加藤寛正, 越智由恵, 植村信隆, Hirohito Honda, Akiyoshi Nishikado, Ichiro Shimizu, 大木崇, Susumu Ito, Ken Saito and Yutaka Nakaya : 老年者における亜硝酸薬投与による胃運動および自律神経活動の関連性:胃電図および心拍変動スペクトル解析による検討, 第26回老年消化器病研究会, Jun. 2001. (Summary) 胃電図の検討で，亜硝酸薬は副交感神経を抑制し胃運動を低下させるため，高齢者に胸痛で投与する際には，GERDの出現·臓悪に注意すべきである．
39.	S Morishita, Masahiro Nomura, Akiyoshi Nishikado, Ken Saito, Takashi Oki, Susumu Ito and Yutaka Nakaya : Evaluation of fatty acid metabolism in the left ventricular myocardium by 123I-BMIPP myocardial scintigraphy in patients with right ventricular overload, The 65th Anniversary Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2001. (Summary) 右室負荷の123I-BMIPP心筋シンチで，左室心筋障害があるかどうか，洗い出し率で検討した．右室負荷例でも左室の脂肪酸代謝障害が存在した．
40.	Masahiro Nomura, Yutaka Nakaya, S Morishita, Tomomi Nada, Hitoshi Miyajima, Ken Saito, Akiyoshi Nishikado, Takashi Oki and Susumu Ito : Visualization of cardiac electrical current using 32-channel high temperature superconducting quantum interference device, The 65th Anniversary Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2001. (Summary) 高温超伝導量子干渉計を用いて心臓磁界を測定し，current density mapを作成した．心房脱分極相，心室脱分極相で良好に心起電力を検出できた．
41.	Masahiro Nomura, Yutaka Nakaya, S Morishita, Tomomi Nada, Hitoshi Miyajima, Ken Saito, Akiyoshi Nishikado, Takashi Oki and Susumu Ito : Relationship between insulin resistance and various parameters in total health promotion planning, The 65th Anniversary Annual Scientific Meeting of the Japanese Circulation Society, Mar. 2001. (Summary) THPは，最大酸素摂取量を増加させ，血中脂質·血圧を低下させるだけでなく，インスリン抵抗性も改善させ，生活習慣病に一次予防に貢献する．
42.	Masahiro Nomura, 森下智文, 名田智美, 宮島等, Akiyoshi Nishikado, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya, Masafumi Harada and Hiromu Nishitani : MR coronary angiographyによる冠動脈血流速波形と99mTc-MIBI運動負荷時血流増加率との関連性, 第9回循環器MR研究会, Feb. 2001. (Summary) MR coronary angiographyによる冠動脈血流速波形のDSVRは99mTc-MIBI運動負荷時血流増加率と有意な相関関係があり，冠動脈予備能を推測できた．
43.	加藤寛正, Masahiro Nomura, 宮島等, 森下智文, Ken Saito, Susumu Ito and Yutaka Nakaya : 臭化ブチルスコポラミンおよびグルカゴンの胃蠕動抑制の比較:胃電図および心拍変動解析による検討, 第37回日本臨床生理学会総会, Nov. 2000. (Summary) ブチルスコポラミンとグルカゴンの胃蠕動抑制を胃電図により比較した．心拍変動解析からグルカゴンは自律神経に影響を与えず，胃運動を抑制できた．
44.	森下智文, Masahiro Nomura, Akiyoshi Nishikado, Ken Saito, 大木崇 and Yutaka Nakaya : MRI Cine PC法を用いた流速測定による心血管圧の推定, 第48回日本心臓病学会学術集会, Sep. 2000. (Summary) ビニールチューブに生理食塩をポンプで流し，MRI Cine PC法で流速を測定すると良好に相関した．ベルヌーイの法則で心血管圧も客観的に推定できた．
45.	森下智文, Masahiro Nomura, Akiyoshi Nishikado, Ken Saito, 大木崇 and Yutaka Nakaya : 食事前後の冠動脈血流速波形の変動:冠動脈MR coronary angiographyによる検討, 第48回日本心臓病学会学術集会, Sep. 2000. (Summary) MR coronary angiographyで，食事前後で冠動脈血流波形を測定した．食後，冠動脈血流速度の低下がみられ，食後狭心症との関連性が示唆された．
46.	Masahiro Nomura, 森下智文, Ken Saito, Akiyoshi Nishikado, 大木崇 and Yutaka Nakaya : 心電図同期四次元MRIを用いた左心機能評価, 第48回日本心臓病学会学術集会, Sep. 2000. (Summary) 心電図同期MRIにて左室内腔を計算して左室時間容積曲線を作成した．心機能は左室造影所見と一致し，拡張能も推定できた．
47.	Masahiro Nomura, 森下智文, Ken Saito, Akiyoshi Nishikado, 大木崇 and Yutaka Nakaya : QT dispersionは加齢の影響をうけるのか?心臓磁界測定による検討, 第48回日本心臓病学会学術集会, Sep. 2000. (Summary) 心臓磁界を用いて心磁図QT dispersionを測定した．左室心筋上の誘導部位にてQT延長があり，加齢とQT dispersionの関連性が示唆された．
48.	森下智文, Masahiro Nomura, 宮島等, 名田智美, Akiyoshi Nishikado, Ken Saito, 大木崇 and Susumu Ito : 99mTc-MIBIによる運動負荷時冠血流増加率と冠動脈血流速波形との関連 : 冠動脈MR coronary angiographyを用いた検討, 第50回循環器負荷研究会, Aug. 2000. (Summary) 微小血管狭心症における冠動脈血流予備能の低下は，99mTc-MIBI の%uptake increaseの低下及び冠動脈血流速波形の異常として検出された．
49.	豊嶋敏弘, Masahiro Nomura, Akiyoshi Nishikado, 宮島等, 近藤幸, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya and Masafumi Harada : 99mTc-tetrofosmin心筋SPECTにおける運動負荷時血流増加率と冠動脈血流速波との関連, 第64回日本循環器学会学術集会, Apr. 2000. (Summary) 99mTc-tetrofosmin心筋SPECTを用いて運動負荷時血流増加率を求めると，冠動脈MRCAでのDSVRと有意な相関関係がみられた．
50.	Masahiro Nomura, Yutaka Nakaya, 宮島等, 近藤幸, 名田智美, Ken Saito, 大木崇 and Susumu Ito : 初期QRSベクトルは心室中隔からのみの心起電力か?心臓磁界による検討, 第64回日本循環器学会学術集会, Apr. 2000. (Summary) 心磁図法を用いて初期QRS波の電流源をMRI画像にマッピングすると，心筋症や心筋梗塞では中隔上になく左室自由壁からの電流も含まれていると思われた．
51.	Masahiro Nomura, 宮島等, 近藤幸, 名田智美, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 検診にてBrugada型心電図を指摘された例における123I-MIBG心筋シンチの検討:ST上昇の形態により違いがあるのか?, 第64回日本循環器学会学術集会, Apr. 2000. (Summary) 健診にてBrugada型心電図と診断された例で，coved型では123I-MIBG心筋シンチの洗い出しが亢進していたが，saddle back型では正常であった．
52.	宮島等, Masahiro Nomura, 近藤幸, 名田智美, Ken Saito, Akiyoshi Nishikado, 大木崇, Susumu Ito and Yutaka Nakaya : WPW症候群におけるカテーテルアブレーション前後における左室壁運動変化:pFAST法による検討, 第64回日本循環器学会学術集会, Apr. 2000. (Summary) WPW症候群でアブレーション前後における左室壁の運動変化をpFAST法でみると，治療前に最早期興奮部位(副伝導路部位)の早期収縮がみられた．
53.	宮島等, Masahiro Nomura, 近藤幸, Tetsuzo Wakatsuki, Akiyoshi Nishikado, Ken Saito, 大木崇, Susumu Ito, Masafumi Harada, Hiromu Nishitani and Yutaka Nakaya : 摂食による冠動脈血流波形の変化:胃電図および冠動脈シネMRAを用いた検討, 第49回循環器負荷研究会, Feb. 2000. (Summary) 食事による胃運動の亢進に伴い，冠動脈に有意狭窄を認める症例では冠動脈血流は有意に低下し，食後の心筋虚血と胃運動との関連性が示唆された．
54.	宮島等, Masahiro Nomura, 名田智美, 近藤幸, Ken Saito and Yutaka Nakaya : 特発性肥大型心筋症における心磁図QT dispersionの検討, 第16回日本心電学会学術集会, Oct. 1999. (Summary) 肥大型心筋症における心磁図QT間隔は，心筋肥大部位の誘導にて延長しており，心筋肥大とQT dispersionの関連性が示唆された．
55.	宮島等, Masahiro Nomura, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : シルニジピン投与による自律神経活動の変化:ニフェジピンとの対比, 第47回日本心臓病学会学術集会, Sep. 1999. (Summary) シルニジピンは自律神経活動に有意な変動はみられなかったが，ニフェジピンでは交感神経活動の亢進および副交感神経活動の低下が認められた．
56.	Masahiro Nomura, 宮島等, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : 肝硬変症における交感神経機能の検討:病期の進行によりhyperdynamic circulationは程度が強くなるのか?, 第47回日本心臓病学会学術集会, Sep. 1999. (Summary) 肝硬変症ではNOが産生され，交感神経機能活性が亢進する．123I-MIBG心筋シンチと心拍変動解析で肝硬変症の病期により交感神経活動の亢進がみられた．
57.	Masahiro Nomura, 宮島等, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : 高齢者における食後低血圧における自律神経活動の影響:胃電図と心拍変動解析による検討, 第47回日本心臓病学会学術集会, Sep. 1999. (Summary) 食後低血圧をおこしやすい高齢者の胃運動と自律神経活動を検討した．原因として，食後の血流調節障害，カテコラミンのdown-regulationが考えられた．
58.	Masahiro Nomura, 宮島等, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : 大腸内視鏡検査中の自律神経活動の変動, 第47回日本心臓病学会学術集会, Sep. 1999. (Summary) 大腸内視鏡検査中の自律神経活動と循環動態について検討した．検査中に，HF値の抑制とLF/HFの亢進がみられた．心事故発生の引き金となりうる．
59.	Masahiro Nomura, 宮島等, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : トータル·ヘルス·プロモーション·プランによる健康保持増進効果, 第47回日本心臓病学会学術集会, Sep. 1999. (Summary) THP(厚生労働省が推奨する健康プラン)により，最大酸素摂取量の増加および生活習慣病危険因子が軽減し，事業所は積極的にTHPを推進すべきと思われた．
60.	Masahiro Nomura, 宮島等, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : 食塩感受性高血圧症における塩酸ベニジピンの作用:心拍変動解析による検討, 第47回日本心臓病学会学術集会, Sep. 1999. (Summary) 心拍変動解析により，塩酸ベニジピンは低食塩摂取者と同様，高食塩摂取患者の血圧および自律神経活動に好ましい影響を与えることが示された．
61.	Masahiro Nomura, 川口律子, 近藤幸, 宮島等, 多田由恵, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 高齢者における食事摂取による血圧変動の成因:心拍変動解析および胃電図における検討, 第48回循環器負荷研究会, Aug. 1999. (Summary) 高齢者の食後低血圧は，胃電図の検討で胃運動の亢進によるものではなく，心拍変動解析によって自律神経活動の代償不全によると考えられた．
62.	Masahiro Nomura, 宮島等, 名田智美, 近藤幸, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : QT dispersionは左室肥大の程度と関連性があるのか?肥大型心筋症における心臓磁界測定による検討, 第18回心脈管研究会, Jul. 1999. (Summary) 肥大型心筋症における心磁図QT dispersionについて検討した．QT延長は，肥大部位の直上の誘導にみられ，心室肥大の程度との関連性が示唆された．
63.	近藤幸, Masahiro Nomura, 宮島等, 名田智美, Ken Saito, Hiroshi Shibata, Susumu Ito and Yutaka Nakaya : 老年者における経皮的エタノール注入療法前後の自律神経機能の変動, 第23回老年消化器病研究討論会, Jun. 1999. (Summary) 老年の肝細胞癌例におけるエタノール注入療法前後の心拍変動解析では副交感神経活動の低下がみられたが，一過性にHF powerが増加する場合もみられた．
64.	Masahiro Nomura, 近藤幸, 由岐中道子, 多田由恵, 川口律子, Hirohito Honda, Ichiro Shimizu, Ken Saito and Susumu Ito : 老年者における摂食後の胃運動と血圧変動, 第41回日本老年病医学会学術集会, Jun. 1999. (Summary) 老年者では食後低血圧がみられる．胃電図による食後胃運動と血圧を自律神経の観点から検討した．老年者の血圧低下は自律神経の反応低下が考えられた．
65.	Masahiro Nomura, 宮島等, 名田智美, 近藤幸, 由岐中道子, 多田由恵, Ken Saito, Susumu Ito and Yutaka Nakaya : QT dispersionの臨床的意義:心臓磁界を用いた心室肥大における検討, 第14回日本生体磁気学会, May 1999. (Summary) 心磁図法は，磁気センサ直下の心起電力を鋭敏に反映する特徴がある．本研究では記録誘導間の心室肥大とQT dispersionの増大との関連性が示唆された．
66.	多田由恵, Masahiro Nomura, 多田津昌也, 日下至弘, 大喜田義雄, 筒井朱美, Naoki Muguruma, Toshiya Okahisa, Seisuke Okamura, Ken Saito and Susumu Ito : 内視鏡的逆行性胆管膵管造影検査施行時における自律神経活動, 第57回日本消化器内視鏡学会総会, May 1999. (Summary) 内視鏡的逆行性胆管膵管造影検査施行時において，胆道内圧の亢進による副交感神経の抑制がみられ，循環動態の変動がみられやすいと考えられた．
67.	名田智美, 近藤幸, Masahiro Nomura, 矢野充保, 由岐中道子, 多田由恵, Ken Saito, Toshiya Okahisa, Hiroshi Shibata, Seisuke Okamura, Hirohito Honda, Ichiro Shimizu and Susumu Ito : 慢性消化性潰瘍における心拍変動1/fゆらぎ解析:自律神経機能異常も潰瘍形成に必要か?, 第57回日本消化器内視鏡学会総会, May 1999. (Summary) 消化性潰瘍では，1/fゆらぎ解析では1/f2ゆらぎとなり，自律神経異常がみられた．H. Pylori感染例でも潰瘍形成ない場合があり，自律神経異常も必要と思われた．
68.	近藤幸, Masahiro Nomura, 名田智美, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : QGSプログラムにおいて梗塞部心筋の壁運動は評価可能か?, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) 梗塞部心筋ではラジオアイソトープが完全に取り込まれず欠損となった部位では壁運動評価が困難であり，特に，左室造影で心室瘤の部位には注意が必要である．
69.	近藤幸, Masahiro Nomura, 名田智美, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 心尖部肥大型心筋症における123I-BMIPP dynamic SPECTの検討:後期心筋洗い出し率との比較, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) dynamic SPECTにより心尖部肥大部位はBMIPPの逆拡散が増大しているが，後期洗い出し率は全segmentで増加し，非肥大部位にも心筋障害がみられた．
70.	近藤幸, Masahiro Nomura, 名田智美, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 交感神経機能異常とTWAとの関連性:僧帽弁逸脱における検討, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) 僧帽弁狭窄例では高率にTWAが陽性となる．心拍変動解析では，本症の交感神経亢進が認められ，TWAと自律神経活動の関連性が示唆された．
71.	由岐中道子, Masahiro Nomura, 近藤幸, 名田智美, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya and Masafumi Harada : 冠動脈MR coronary angiographyにより微小血管性狭心症の診断は可能か?, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) 運動負荷でST低下を認めるが冠動脈造影で有意狭窄のない症例について冠動脈MRCAを撮像した．DSVRが有意に低下し，微小血管性狭心症と診断できた．
72.	由岐中道子, Masahiro Nomura, 近藤幸, 名田智美, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya and Masafumi Harada : 糖尿病における心筋細胞機能障害の検出:123I-MIBG/99mTc-MIBIにおける検討, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) 123I-MIBG/99mTc-MIBIのミスマッチにより糖尿病における心筋細胞機能障害を検出した．ミスマッチが大であれば，不整脈等の合併症に注意すべきである．
73.	由岐中道子, Masahiro Nomura, 近藤幸, 名田智美, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya and Masafumi Harada : 冠動脈MR coronary angiographyを用いた本態性高血圧症における冠動脈血流速波形の検討, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) 高血圧例のMRCAにおいて，ASPVは健常例と有意差はなかったが，ADPVとDSVRは有意に小さかった．高血圧心の微小循環障害と思われた．
74.	由岐中道子, Masahiro Nomura, 近藤幸, 名田智美, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya and Masafumi Harada : 糖尿病における冠動脈微小循環障害をMR coronary angiographyにより診断可能か?, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) 冠動脈造影で有意狭窄のない糖尿病例でMRCAを撮像して冠動脈血流速波形を検討した．ASPVとADPVとの比(DSVR)は低下しており微小循環障害と思われた．
75.	由岐中道子, Masahiro Nomura, 近藤幸, 名田智美, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya and Masafumi Harada : 肥大型心筋症における冠動脈血流速動態と99mTc-Tetrofosmin心筋シンチグラフィとの対比, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) MRCAにて計測した肥大型心筋症の冠動脈血流速波形は健常例での2峰性パターンが消失し，TF心筋シンチでの洗い出しと相関関係がみられた．
76.	Masahiro Nomura, 名田智美, 近藤幸, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 心室肥大とQT dispersionとの関連性:心臓磁界における検討, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) 心磁図は位置分解能がよくセンサ直下の電流を鋭敏に捉えられる．心筋肥大部位直上の誘導でQT延長がみられ，心室肥大とQT dispersionの延長との関連していた．
77.	Masahiro Nomura, 名田智美, 近藤幸, 由岐中道子, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya and 七條茂文 : トータル·ヘルス·プロモーション·プランによる生活習慣病の予防効果:最大酸素摂取量との関連性について, 第63回日本循環器学会学術集会, Mar. 1999. (Summary) THPは労働者の健康保持増進に貢献する．運動処方により最大酸素摂取量は増加し，脂質や血圧等の生活習慣病の健康パラメータの改善がみられた．
78.	由岐中道子, Masahiro Nomura, 名田智美, 近藤幸, Ken Saito, 大木崇, Yutaka Nakaya and Masafumi Harada : 肥大型心筋症における冠動脈血流速波形と心筋細胞機能との関連性:MR coronary angiography (MRCA) と99mTc-Tetrofosmin心筋シンチグラフィによる検討, 第7回循環器MR研究会, Feb. 1999. (Summary) 肥大型心筋症の冠動脈血流速波形は健常例での2峰性パターンがくずれ，99mTc-Tetrofosmin心筋シンチでの洗い出しの異常との相関関係がみられた．
79.	近藤幸, Masahiro Nomura, 名田智美, 由岐中道子, Ken Saito, Yutaka Nakaya, 田岡良章 and Masafumi Harada : 肝硬変例における門脈血行動態の変化:MRAによる血流速度の検討, 第34回日本臨床生理学会総会, Oct. 1998. (Summary) MRAを用いて門脈血流量を測定した．肝硬変症では，摂食後の門脈血流量の増加率の減少がみられ，摂食による胃運動機能低下の成因の一つと考えられた．
80.	由岐中道子, Masahiro Nomura, 名田智美, 近藤幸, Ken Saito and Yutaka Nakaya : Brugada症候群におけるHead-up tilt test:心拍変動およびSTレベルの検討, 第34回日本臨床生理学会総会, Oct. 1998. (Summary) Brugada症候群は，自律神経の影響でSTが変動する．Head-up tilt test中の自律神経とST変化を観察することにより，Brugada型心電図のST上昇を予測できる．
81.	Masahiro Nomura, 名田智美, 近藤幸, 由岐中道子, Ken Saito, Susumu Ito, Yutaka Nakaya and 七條茂文 : トータル·ヘルス·プロモーション·プラン(THP)における健康測定項目と最大酸素摂取量との関連性, 第34回日本臨床生理学会総会, Oct. 1998. (Summary) THPにおいて最大酸素摂取量を自転車エルゴメータにより測定した．最大酸素摂取量が多いと，健康測定項目値は改善し，生活習慣病の一次予防に貢献できる．
82.	近藤幸, Masahiro Nomura, 名田智美, 由岐中道子, Ken Saito and Yutaka Nakaya : 僧帽弁逸脱におけるT Wave Alternans (TWA)の検討, 第15回日本心電学会学術集会, Oct. 1998. (Summary) 僧帽弁逸脱ではT Wave Alternans (TWA)が陽性となる場合が多い．心拍変動解析より，本症では自律神経異常がみられ，TWAとの関連性が示唆された．
83.	由岐中道子, Masahiro Nomura, 名田智美, 近藤幸, Ken Saito and Yutaka Nakaya : 初期QRSベクトルは心室中隔の心起電力よりなるのか?心滋図法を用いた検討, 第15回日本心電学会学術集会, Oct. 1998. (Summary) 初期QRSベクトルは，心筋梗塞症と心筋症の電流源の検出により心室中隔の心起電力以外に左室自由壁の電流も加味されていると思われた．
84.	近藤幸, Masahiro Nomura, 由岐中道子, Tetsuzo Wakatsuki, Akiyoshi Nishikado, Ken Saito, 大木崇 and Yutaka Nakaya : 大動脈弁狭窄症におけるCine MRアンギオを用いた左室-大動脈間圧較差の測定, 第46回日本心臓病学会学術集会, Sep. 1998. (Summary) MRIを用いて流速が測定できる．大動脈弁狭窄症におけるCine MRアンギオを用いた左室-大動脈間圧較差の測定を行いカテーテル圧と良好に相関した．
85.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, 大木崇 and Yutaka Nakaya : インターフェロン療法における心筋障害の検出:123I-BMIPP心筋シンチグラフィによる評価, 第46回日本心臓病学会学術集会, Sep. 1998. (Summary) 慢性C型肝炎によるインターフェロンの心筋障害早期検出を，123I-BMIPP心筋シンチで検討した．心電図異常のみられる前に洗い出しが異常となった．
86.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, 大木崇 and Yutaka Nakaya : 心尖部肥大，非対称性中隔肥大および拡張相肥大型心筋症における心筋細胞機能異常の検討:99mTc-Tetrofosmin保持障害の有無による検討, 第46回日本心臓病学会学術集会, Sep. 1998. (Summary) 心尖部肥大型心筋症では肥大部位のみでミトコンドリア異常がみられたが，ASH型の心筋症では非肥大部位においてもミトコンドリア異常がみられた．
87.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, 大木崇 and Yutaka Nakaya : 心尖部肥大，非対称性中隔肥大および拡張相肥大型心筋症における心筋細胞機能異常の検討:99mTc-Tetrofosmin保持障害の有無による検討, 第46回日本心臓病学会学術集会, Sep. 1998. (Summary) 心尖部肥大型心筋症では肥大部位のみでミトコンドリア異常がみられたが，ASH型の心筋症では非肥大部位においてもミトコンドリア異常がみられた．
88.	近藤幸, Masahiro Nomura, 由岐中道子, Akiyoshi Nishikado, Ken Saito, 大木崇 and Yutaka Nakaya : 冠動脈ステントはMRI磁場により影響をうけるか?, 第46回日本心臓病学会学術集会, Sep. 1998. (Summary) MRI室内にステントをおいて，位置の移動とサーモグラフによる温度変化みた．ステントの温度変化と位置の移動はなく，MRI検査は支障ないと判断された．
89.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : 99mTc-MIBIおよび123I-MIBG心筋シンチグラフィーの心筋集積解離と心室性不整脈との関連性:陳旧性心筋梗塞症例における検討, 第46回日本心臓病学会学術集会, Sep. 1998. (Summary) MIBIとMIBG心筋シンチの心筋集積解離と心室性不整脈との関連性をホルタ心電図と遅延電位で検討した．ミスマッチのある例は心室頻拍が多かった．
90.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : 冠動脈MR coronary angiographyを用いた冠動脈側副血行路の血流速波形の検討, 第46回日本心臓病学会学術集会, Sep. 1998. (Summary) 冠動脈MR coronary angiographyを用いて，心筋梗塞症における冠動脈側副血行路の血流速波形を検討した．フローワイアでは検出困難な血流が測定できた．
91.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : MR coronary angiographyから求めた冠動脈血流速波形による冠動脈病変の診断精度に関する検討, 第46回日本心臓病学会学術集会, Sep. 1998. (Summary) MR coronary angiographyから求めた冠動脈血流速波形より，ASPV, ADPV, DSVRを測定し，冠動脈狭窄診断精度を検討した．感度·特異度は良好であった．
92.	Masahiro Nomura, 名田智美, 近藤幸, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 僧帽弁逸脱におけるT wave alternanceの意義, 第46回循環器負荷研究会, Aug. 1998. (Summary) 僧帽弁逸脱例について，TWA出現は心室遅延電位との関連性は認めなかったが，運動時の交感神経機能の亢進とは何らかの関連性があると推察された．
93.	近藤幸, Masahiro Nomura, 名田智美, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : T Wave Alternansと自律神経機能異常との関連性:僧帽弁逸脱における検討, 第17回心脈管研究会, Jul. 1998. (Summary) 僧帽弁逸脱においてT Wave Alternansが陽性となる場合が多いが，心拍変動解析で交感神経が亢進し，自律神経機能異常との関連性が示唆された．
94.	Masahiro Nomura, 名田智美, 近藤幸, 由岐中道子, Toshiya Okahisa, Hiroshi Shibata, Seisuke Okamura, Hirohito Honda, Ichiro Shimizu, Ken Saito, Susumu Ito and Yutaka Nakaya : 慢性消化性潰瘍形成において自律神経機能異常は必要条件か?心拍変動1/fゆらぎおよびHelicobactor pyroliとの関連性, 第15回四国消化性潰瘍研究会, May 1998. (Summary) 慢性消化性潰瘍形成で自律神経異常は必要条件か検討した．潰瘍例で心拍変動1/fゆらぎは異常があり，pylori感染以外に自律神経異常が必要である．
95.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito, 大木崇, Susumu Ito, 田岡良章, Masafumi Harada and Yutaka Nakaya : MRIを用いた高速撮像phase contrast法による硝酸イソソルビド投与による冠動脈血流速波形の検討, 第95回日本内科学会講演会, Apr. 1998. (Summary) MRIを用いて，高速撮像phase contrast法により冠動脈血流速波形を記録した．硝酸イソソルビド投与を行うと，冠動脈血流速度が低下した．
96.	岸史子, Masahiro Nomura, 由岐中道子, 近藤幸, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : Human chymaseによるbig endothelinのprocessing-endothelin (1-31)の生成とその生理活性についての検討, 第62回日本循環器学会学術集会, Mar. 1998. (Summary) Human chymaseはbig endothelin (ET)に作用し新規化合物ET (1-31)を生成した．ET (1-31)は，ET (1-21)とは異なった経路を介し心肥大·動脈硬化に関与している．
97.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya and 恵美滋文 : 慢性肝炎におけるインターフェロン療法における心筋障害の検出:123I-BMIPP心筋シンチグラフィーによる評価, 第62回日本循環器学会学術集会, Mar. 1998. (Summary) 慢性肝炎におけるインターフェロン療法の心筋障害を123I-BMIPP心筋シンチにて検出した．心電図やエコーで異常がみられない以前に異常が検出できた．
98.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : MRアンギオ(Cine PC法)を用いた本態性高血圧の脳血流速度の評価, 第62回日本循環器学会学術集会, Mar. 1998. (Summary) Cine PC法により頭蓋内動脈血流速度を測定し，ドプラ波形と対比して検討した．高血圧症では，頭蓋内血流異常がみられた．
99.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, Akiyoshi Nishikado, 大木崇, Susumu Ito, Yutaka Nakaya and 田岡良章 : MR coronary angiographyにおいてcoronary stent留置後の再狭窄の評価は可能か?, 第62回日本循環器学会学術集会, Mar. 1998. (Summary) MR coronary angiographyでは，coronary stentはアーチファクトがみられるが，stent末梢の血流速度を撮像することにより再狭窄の評価は可能であった．
100.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito, 大木崇, Susumu Ito, 田岡良章, Masafumi Harada and Yutaka Nakaya : 硝酸イソソルビド投与およびニフェジピンの冠循環におよぼす影響:fCARD PCを用いた冠動脈血流速度による検討, 第62回日本循環器学会学術集会, Mar. 1998. (Summary) fCARD PCを用いて，硝酸イソソルビドおよびニフェジピン投与による冠動脈血流速度を求めた．血流速波形が各薬剤にて特徴的に変化した．
101.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 右室負荷疾患において99mTc-Tetrofosmin心筋シンチにおける洗い出し率による検討, 第62回日本循環器学会学術集会, Mar. 1998. (Summary) 右室負荷疾患において99mTc-Tetrofosmin心筋シンチにおける洗い出し率を検討した．右室心筋に関心領域の洗い出しは右室圧と良好な相関がみられた．
102.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito, 大木崇, Susumu Ito, 田岡良章, Masafumi Harada and Yutaka Nakaya : MR coronary angiographyによる健常および虚血心筋へ灌流する冠動脈血流速波形の検討, 第62回日本循環器学会学術集会, Mar. 1998. (Summary) MR coronary angiographyで健常および虚血心筋へ灌流する冠動脈血流速波形を検討した．冠動脈狭窄例では血流速度の低下とパターンの変化がみられた．
103.	Masahiro Nomura, 近藤幸, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 加齢により心起電力の大きさは減少するのか? 心臓磁界から求めた電流dipoleの大きさによる検討, 第62回日本循環器学会学術集会, Mar. 1998. (Summary) 心起電力は，加齢そのもの或いは，胸郭，皮下脂肪·筋肉，肺の含気量等の変化が影響するのかについて検討した．加齢に伴い心起電力は変動しなかった．
104.	Masahiro Nomura, 近藤幸, 由岐中道子, Ken Saito, Yutaka Nakaya and Susumu Ito : 99mTc-Tetrofosmin心筋シンチによる急性心筋梗塞例の逆再分布の検討:Dynamic SPECT画像との対比, 第34回日本臨床生理学会総会, Oct. 1997. (Summary) 99mTc-Tetrofosmin心筋シンチによる急性心筋梗塞例の逆再分布をDynamic SPECT画像と対比した．心筋障害部位はDynamic画像でも洗い出しが亢進した．
105.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, Yutaka Nakaya and Susumu Ito : 小腸磁界測定による小腸運動機能評価:超伝導量子干渉計による検討, 第34回日本臨床生理学会総会, Oct. 1997. (Summary) 小腸磁界測定を測定した．この磁気信号はスペクトル解析すると小腸磁界と胃磁界を分離できて，それぞれ定量化して消化管運動を評価できた．
106.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito, Susumu Ito, Yutaka Nakaya, 田岡良章 and Masafumi Harada : 両側冠動脈肺動脈瘻の非侵襲的診断:冠動脈MR angiography(MRCA)を用いた評価, 第34回日本臨床生理学会総会, Oct. 1997. (Summary) 冠動脈MR angiography(MRCA)を用いて，両側冠動脈肺動脈瘻の非侵襲的診断を行った．心臓血管造影とほぼ同様の所見が得られ，臨床的に有用である．
107.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito and Yutaka Nakaya : 肝硬変症における心拍変動1/fゆらぎの概日リズムと123I-MIBG心筋シンチによる交感神経異常, 第14回日本心電学会学術集会, Oct. 1997. (Summary) 肝硬変症はNO産生亢進による自律神経障害がある．心拍変動1/fゆらぎの概日リズムと123I-MIBG心筋シンチによる交感神経異常が早期からみられた．
108.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito and Yutaka Nakaya : 99mTc-MIBIおよび123I-MIBGの心筋集積解離と心室遅延電位との関連性:陳旧性心筋梗塞症における検討, 第14回日本心電学会学術集会, Oct. 1997. (Summary) 123I-MIBGと99mTc-MIBI心筋シンチのミスマッチが大きい群では，遅延電位が認められ，重症の心室性不整脈がみられた．
109.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, 岸史子, 大木崇 and Yutaka Nakaya : 99mTc-Tetrofosmin心筋シンチによる肥大型心筋症における心筋細胞機能異常の検討, 第45回日本心臓病学会学術集会, Sep. 1997. (Summary) 99mTc-Tetrofosmin心筋SPECTで肥大型心筋症における心筋細胞ミトコンドリア機能を検討した．洗い出し率の亢進により，心筋症の予後推定が可能と思われた．
110.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, 大木崇 and Yutaka Nakaya : 大量輸血後の可逆性心筋梗塞における虚血性変化:123I-MIBG/99mTc-MIBI心筋シンチによる検討, 第45回日本心臓病学会学術集会, Sep. 1997. (Summary) 大量輸血で虚血性心電図変化がでた症例を経験した．99mTc-MIBIと123I-MIBG心筋シンチで解離した所見がみられ，可逆性心筋梗塞に有用と思われた．
111.	由岐中道子, Masahiro Nomura, 近藤幸, Ken Saito, 大木崇, Yutaka Nakaya, 井上実, 黒沢裕之 and 田沢周作 : AmlodipineおよびNifedipineの交感神経におよぼす影響:ラットでの123I-MIBG心筋シンチでの検討, 第45回日本心臓病学会学術集会, Sep. 1997. (Summary) ラットでの123I-MIBG心筋シンチにおいて，nifedipineは交感神経の亢進がみられたが，amlodipineの心臓交感神経の亢進作用を認めないことが確認された．
112.	Masahiro Nomura, 岸史子, 由岐中道子, 近藤幸, Ken Saito, 大木崇 and Yutaka Nakaya : 食事摂取による特異動的作用時のエネルギー代謝と自律神経活動:呼気ガス分析と心拍変動解析による検討, 第45回日本心臓病学会学術集会, Sep. 1997. (Summary) 食事摂取後は特異動的作用によりエネルギー代謝は亢進するが，心拍数は増加しない．心拍変動解析より，その成因として食後の交感神経の抑制が考えられた．
113.	Masahiro Nomura, 由岐中道子, 近藤幸, 岸史子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : Dihydropyridine系Ca拮抗薬の心臓交感神経機能への影響:123I-MIBG心筋シンチでの検討, 第44回循環器負荷研究会, Aug. 1997. (Summary) 123I-MIBG心筋シンチにおいて，nifedipineは交感神経活性の亢進がみられたが，amlodipineの心臓交感神経活性の亢進作用が認められないことが確認された．
114.	Masahiro Nomura, Yutaka Nakaya, 由岐中道子, 近藤幸, Ken Saito and Susumu Ito : 心磁図法によるQTc dispersion:心筋梗塞症による検討, 第12回日本生体磁気学会, May 1997. (Summary) QT間隔のばらつきは，心磁図法で良好な検出がえられ，心筋虚血を示す誘導部位で延長がみられ，心筋虚血とQT dispersion増大との関連性が示唆された．
115.	岸史子, Masahiro Nomura, 由岐中道子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : ブタ血管内皮細胞におけるNO産生に対するhistamine recepter subtypeの関与, 第61回日本循環器学会総会学術集会, Mar. 1997. (Summary) histamineは血管内皮からNOを産生する．ブタ血管内皮細胞におけるhistamineによるNO産生はH2レセプターを介したcAMPの上昇によりおこると考えられた．
116.	近藤幸, Masahiro Nomura, 由岐中道子, Ken Saito, Tomotsugu Tabata, 井内新, 大木崇, Susumu Ito, Masafumi Harada, 田岡良章 and Yutaka Nakaya : シネMRAによる僧帽弁口および肺静脈血流速波形の評価:パルス·ドプラ法との比較-, 第61回日本循環器学会総会学術集会, Mar. 1997. (Summary) シネMRAによる僧帽弁口および肺静脈血流速波形を記録して，パルス·ドプラ法と比較すれば良好な相関関係があり，心腔内の決流速度にも応用できる．
117.	由岐中道子, Masahiro Nomura, 近藤幸, 岸史子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 陳旧性心筋梗塞における99mTc-MIBIおよび123I-MIBG心筋SPECTの心筋集積解離:心室遅延電位(LP)との関連, 第61回日本循環器学会総会学術集会, Mar. 1997. (Summary) 陳旧性心筋梗塞における99mTc-MIBIおよび123I-MIBG心筋SPECTの心筋集積解離が見られる例で心室遅延が陽性となり，心室頻拍と関連していた．
118.	由岐中道子, Masahiro Nomura, 近藤幸, 岸史子, Tetsuzo Wakatsuki, Akiyoshi Nishikado, Ken Saito, 大木崇, Susumu Ito, Masafumi Harada, 田岡良章 and Yutaka Nakaya : Magnetic Resonance Coronary Angiography (MRCA)によるPTCA前後での冠動脈血流速度-再狭窄診断への応用-, 第61回日本循環器学会総会学術集会, Mar. 1997. (Summary) Magnetic Resonance Coronary Angiography (MRCA)によるPTCA前後での冠動脈血流速度は，治療後で増加し，再狭窄診断の応用が可能と思われた．
119.	Masahiro Nomura, 由岐中道子, 近藤幸, 岸史子, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : QT dispersionと心筋虚血ベクトルの関連性:心臓磁界測定による検討, 第61回日本循環器学会総会学術集会, Mar. 1997. (Summary) 心臓磁界測定により，心筋梗塞例におけるQT dispersionを検討すると，梗塞周囲でQTの延長がみられ，心筋虚血ベクトルの関連が示唆された．
120.	Masahiro Nomura, 由岐中道子, 近藤幸, Ken Saito, 大木崇, Susumu Ito and Yutaka Nakaya : 初期QRSベクトルは心室中隔の起電力によって生じるか? -心臓磁界測定による心室中隔ベクトルの三次元的位置測定による検討-, 第61回日本循環器学会総会学術集会, Mar. 1997. (Summary) 心臓磁界測定による心室中隔ベクトルの三次元的位置測定により，初期QRSベクトルを推定にて，心室中隔以外に左室自由壁も関与していると思われた．
121.	由岐中道子, Masahiro Nomura, Ken Saito, 岸史子, 大木崇, Susumu Ito and Yutaka Nakaya : 99mTc-MIBI gated SPECTを用いた三次元perfusion/mortion map法による局所的心機能評価-短軸画像上での壁運動評価-, 第33回日本臨床生理学会, Oct. 1996. (Summary) 99mTc-MIBI gated SPECTを用いた三次元perfusion/ mortion map法により，短軸画像上での壁運動評価を行うと，左室造影所見と良好な相関があった．
122.	Masahiro Nomura, 由岐中道子, Ken Saito, Susumu Ito and Yutaka Nakaya : 食事摂取による特異動的作用時のエネルギー代謝と自律神経活動-呼気ガス分析と心拍変動解析による検討, 第33回日本臨床生理学会, Oct. 1996. (Summary) 食事摂取による特異動的作用時のエネルギー代謝は亢進するが，心拍数の増加が見られない．これは，HF値の増加による抑制があるためと思われた．
123.	由岐中道子, Masahiro Nomura, Ken Saito and Yutaka Nakaya : 左室負荷疾患の初期QRSベクトルの検討ー心臓磁界計測による信号源の位置推定, 第13回日本心電図学会学術集会, Oct. 1996. (Summary) 心臓磁界計測による信号源の位置推定し，左室負荷疾患の初期QRSベクトルを検討すると，心室中隔上にはなく，後方に変位していた．
124.	Masahiro Nomura, 由岐中道子, Ken Saito and Yutaka Nakaya : 食事摂取による特異動的作用時のエネルギー代謝と自律神経活動-呼気ガス分析と心拍変動解析による検討, 第13回日本心電図学会学術集会, Oct. 1996. (Summary) 食事摂取による特異動的作用時のエネルギー代謝は亢進するが，心拍数の上昇が少ない原因として，副交感神経の亢進が原因のひとつと考えられた．
125.	由岐中道子, Masahiro Nomura, Ken Saito, Masafumi Harada, 田岡良章 and Yutaka Nakaya : First Cardiac Gating Acquisitionによる冠動脈の描出-冠動脈血流信号の心時相における変化の検討-, 第44回日本心臓病学会学術集会, Sep. 1996. (Summary) 心電図同期MRCA画像より，冠動脈決流速波形を記録した．ドプラワイアと同様の拡張期有意の2峰性の波形が得られ，臨床応用可能であると思われた．
126.	Masahiro Nomura, 由岐中道子, 岸史子, Ken Saito and Yutaka Nakaya : 長時間運動負荷後の回復過程のエネルギー消費量および自律神経活動の検討, 第44回日本心臓病学会学術集会, Sep. 1996. (Summary) 長時間の運動負荷後，酸素摂取量の増加の亢進が残存することに，交感神経の緊張が関与された．また，副交感神経活動も同時に緊張していた．
127.	由岐中道子, Masahiro Nomura, 岸史子, Ken Saito, Tomotsugu Tabata, Akiyoshi Nishikado, 井内新, 大木崇, Susumu Ito and Yutaka Nakaya : 陳旧性心筋梗塞における99mTc-MIBIおよび123I-MIBG心筋シンチ比較, 第15回心脈管研究会, Jul. 1996. (Summary) 陳旧性心筋梗塞における99mTc-MIBIおよび123I-MIBG心筋シンチ比較して，missmatch部分の存在が，不整脈の出現と関連していると思われた．
128.	Masahiro Nomura, 由岐中道子, 岸史子, Ken Saito, Susumu Ito and Yutaka Nakaya : 特発性心筋症における初期QRSベクトルの信号源, 第11回日本生体磁気学会大会, May 1996. (Summary) 特発性心筋症における初期QRSベクトルの信号源を心磁図により推定した．初期QRS波の時点から電流源は心室中隔になく，自由壁の興奮が起こっていた．
129.	岸史子, Masahiro Nomura, Ken Saito, 西條哲也, 大木崇, Susumu Ito and Yutaka Nakaya : 上部内視鏡検査時の自律神経活動ー血圧変動および心拍変動スペクトル解析の比較ー, 第60回日本循環器学会総会, Mar. 1996. (Summary) 上部内視鏡検査時の自律神経活動を血圧·心拍変動スペクトル解析で検討すると，検査中のLF/HF比の増加とHF値の減少がみられた．
130.	Masahiro Nomura, Ken Saito, 岸史子, 大木崇, Susumu Ito and Yutaka Nakaya : 心電図検診における右脚ブロックパターン例の自律神経活動の検討ー心拍変動スペクトル解析および123I-MIBG心筋シンチによる検討ー, 第60回日本循環器学会総会, Mar. 1996. (Summary) 心電図検診における右脚ブロックパターン例の自律神経活動を心拍変動スペクトル解析と123I-MIBG心筋シンチで検討し，自律神経異常がみられた．
131.	Masahiro Nomura, 岸史子, 由岐中道子, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya and 大中政治 : 長時間運動負荷後の回復過程のエネルギー代謝と自律神経活動の検討ー呼気ガス分析と心拍変動解析による検討ー, 第42回循環器負荷研究会, Feb. 1996. (Summary) 長時間の運動負荷後，酸素摂取量の増加の亢進が残存することに，交感神経の緊張が関与された．また，副交感神経活動も同時に緊張していた．
132.	Masahiro Nomura, 西條哲也, 岸史子, Ken Saito, Yutaka Nakaya and Susumu Ito : 機械的胃運動機能の客観的評価, 第32回日本臨床生理学会総会, Oct. 1995. (Summary) 胃管の先端に小鉄球を取り付け，胃内に挿入して，鉄球の動きにより生じる磁界を高温超伝導磁束計で測定した．3cpmの胃運動が観察された．
133.	岸史子, Masahiro Nomura, Yutaka Nakaya and Ken Saito : 経皮的肝癌エタノール注入療法時の自律神経活動, 第12回日本心電学会学術集会, Oct. 1995. (Summary) 経皮的肝癌エタノール注入療法時の自律神経活動を心拍変動解析にて検討した．HF値の亢進時に，心拍の減少がみられ，心事故との関連性が示唆された．
134.	Masahiro Nomura, Yutaka Nakaya, Ken Saito and 岸史子 : 心磁図法による初期QRSベクトルの電流源の位置:心筋症および前壁心筋梗塞症での検討, 第12回日本心電学会学術集会, Oct. 1995. (Summary) 心磁図法で初期QRSベクトルの電流源の位置を心筋症と前壁梗塞症で比較した．異常Q波があるが，信号源の位置は異なり，その成因が異なると思われた．
135.	岸史子, Masahiro Nomura, 三好宏和, Ken Saito and Yutaka Nakaya : 僧帽弁逸脱症における交感神経機能評価, 第43回日本心臓病学会学術集会, Sep. 1995. (Summary) 僧帽弁逸脱症における交感神経機能を123I-MIBG心筋シンチにて評価した．洗い出し率は亢進しており，僧帽弁逸脱症の自律神経異常を反映していた．
136.	岸史子, Masahiro Nomura, 三好宏和, Ken Saito and Yutaka Nakaya : ブタ胸部大動脈内皮細胞におけるNO産生へのhistamine receptor subtypeの関与について, 第43回日本心臓病学会学術集会, Sep. 1995. (Summary) histamineは血管内皮からNOを産生する．ブタ血管内皮細胞におけるhistamineによるNO産生はH2レセプターを介したcAMPの上昇によりおこると考えられた．
137.	Masahiro Nomura, 岸史子, 三好宏和, Ken Saito and Yutaka Nakaya : 99mTc-MIBIを用いた3次元perfusion/motion map法による局所的心機能評価ー左室造影との比較ー, 第43回日本心臓病学会学術集会, Sep. 1995. (Summary) 99mTc-MIBIを用いた3次元perfusion/motion map法による局所的心機能評価を左室造影と，Centerline methodによりSFを比較すると良好な相関があった．
138.	Masahiro Nomura, 岸史子, 三好宏和, Ken Saito and Yutaka Nakaya : L-アルギニンおよび硝酸イソソルバイド負荷による自律神経活動の検討, 第43回日本心臓病学会学術集会, Sep. 1995. (Summary) L-アルギニンと硝酸イソソルバイド負荷による自律神経活動の検討を心拍変動解析でおこなった．両薬剤ともに，反射性の交感神経活動の亢進がみられた．
139.	Masahiro Nomura, 岸史子, Ken Saito, 大木崇, Susumu Ito, Yutaka Nakaya, 大中政治 and Hideki Matoba : 長時間運動後のエネルギー代謝におよぼす影響, 第41回循環器負荷研究会, Aug. 1995. (Summary) 長時間運動負荷後，エネルギー代謝は運動後7時間を7時間を経過しても増加し，そのエネルギー源として体内の脂肪が利用されていると考えられた．
140.	岸史子, Masahiro Nomura, Ken Saito, 福田信夫, 大木崇, Susumu Ito and Yutaka Nakaya : 123I-MIBG心筋シンチ法による僧帽弁逸脱の交感神経機能評価, 第6回弁と弁疾患研究会, Jul. 1995. (Summary) 23I-MIBG心筋シンチ法で僧帽弁逸脱の交感神経機能評価を行った．洗い出し率は健常例に比して有意に亢進し自律神経異常を反映していると思われた．
141.	Masahiro Nomura, 西條哲也, 岸史子, Ken Saito, Akiyoshi Nishikado, Susumu Ito and Yutaka Nakaya : 急性ストレス下の自律神経活動, 第14回心脈管研究会, Jul. 1995. (Summary) 急性ストレスとして，消化管内視鏡検査施行時の心拍変動解析にて，自律神経活動の変動を検討した．ストレス反応時にはLF/HFの増加がみられた．
142.	Yutaka Nakaya, Masahiro Nomura, 岸史子, 三好宏和, Ken Saito and Susumu Ito : 前壁心筋梗塞症および健常例の初期QRSベクトルの信号源推定, 第10回日本生体磁気学会大会, May 1995. (Summary) 前壁心筋梗塞症と健常例の初期QRSベクトルの信号源を心磁図により推定した．健常例では，心室中隔にあったが，前壁梗塞例では後方に変位していた．
143.	岸史子, Masahiro Nomura, 三好宏和, Ken Saito, Yutaka Nakaya and Susumu Ito : 99mTc-MIBI心拍同期SPECTによる心機能評価法―収縮による梗塞部の心筋のねじれの影響, 第59回日本循環器学会学術集会, Apr. 1995. (Summary) 99mTc-MIBI心拍同期SPECTを用いて心機能評価法を行った．心筋梗塞の欠損部位のねじれ補正によりでは誤差を少なくできる．
144.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 三好宏和 and Susumu Ito : 心臓磁界測定による心房性再分極波の検討―電流源の3次元位置推定, 第59回日本循環器学会学術集会, Apr. 1995. (Summary) 心臓磁界測定により，心房性再分極波の電流源を3次元的に位置推定して，心電図同期MRI画像上にマッピングした．推定心起電力は心房由来であった．
145.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 三好宏和 and Susumu Ito : ホルター心電図と運動負荷時の呼気ガス分析を併用した1日のエネルギー消費量の推定, 第59回日本循環器学会学術集会, Apr. 1995. (Summary) 運動負荷時の各心拍数時の酸素摂取量よりエネルギー消費量を測定して，ホルター心電図からの心拍数から1日のエネルギー消費量を推定した．
146.	西條哲也, Masahiro Nomura, 林亨, Ken Saito, 岸史子, Hirohito Honda, Ichiro Shimizu, 大木崇, Susumu Ito and Yutaka Nakaya : 血圧変動および心拍変動解析による急性ストレス負荷時の自律神経活動の検討, 第40回循環器負荷研究会, Feb. 1995. (Summary) 消化器内視鏡中の急性ストレス時における血圧·心拍変動解析による自律神経活動では，検査中交感神経活動が亢進し，心事故の関連性が示唆された．
147.	西條哲也, Masahiro Nomura, Ken Saito, Toshiya Okahisa, Seisuke Okamura, Hirohito Honda, Ichiro Shimizu, Susumu Ito, 篠原尚典, 山本浩史 and 折野俊介 : 心拍変動解析による大腸内視鏡検査時の自律神経機能の検討, 第31回日本臨床生理学会総会, Nov. 1994. (Summary) 心拍変動解析により大腸内視鏡検査時の自律神経機能を検討した．検査中，交感神経の指標LF/HF値が亢進しており，心事故との関連性が示唆された．
148.	Masahiro Nomura, 岸史子, Ken Saito, Yutaka Nakaya and Susumu Ito : 心拍変動解析による運動負荷時の自律神経活動ー本態性高血圧症における検討, 第31回日本臨床生理学会総会, Nov. 1994. (Summary) 本態性高血圧症における心拍変動解析による運動負荷時の自律神経活動を検討した．健常例に比して，負荷中の交感神経の指標LF/HF値が亢進していた．
149.	西條哲也, Masahiro Nomura, 安田貢, 堀江貴浩, 堀江千昌, 柴昌子, 西角智子, 溝渕洋子, Hirohito Honda, Ichiro Shimizu, Ken Saito and Susumu Ito : トノメトリー連続血圧測定法による内視鏡ファイバー挿入時の自律神経活動, 第48回日本消化器内視鏡学会総会, Oct. 1994. (Summary) トノメトリー血圧測定法により内視鏡挿入時の自律神経活動を検討した．内視鏡検査中は，副交感神経の低下があり，心事故と関連が示唆された．
150.	三好宏和, 岸史子, Masahiro Nomura, Ken Saito and Yutaka Nakaya : Calcitonin generated peptide (OGRT)の血管平滑筋Kチャンネルに対する活性化機序, 第11回日本心電学会学術集会, Oct. 1994. (Summary) CGRPは血管平滑筋でIAP-sensitiveなG蛋白を介したセカンドメッセンジャーにより血管平滑筋細胞Kチャンネルを活性化し，血管張力の調節に関与している．
151.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子 and 三好宏和 : 本態性高血圧症における心房性Ta波:心磁図法による検討, 第11回日本心電学会学術集会, Oct. 1994. (Summary) 心磁図法により本態性高血圧症における心房性Ta波を検討した．磁界分布図により心房負荷による心房性再分極波が検出できた．
152.	三好宏和, 岸史子, Masahiro Nomura, Ken Saito and Yutaka Nakaya : 冠動脈平滑筋細胞Kチャンネルに対するCalcitonin generated peptide (OGRT)の作用, 第7回Nicorandil研究会, Oct. 1994. (Summary) CGRPは血管平滑筋でIAP-sensitiveなG蛋白を介したセカンドメッセンジャーにより血管平滑筋細胞Kチャンネルを活性化し，血管張力の調節に関与している．
153.	岸史子, Masahiro Nomura, Ken Saito, Yutaka Nakaya, 篠原尚典, 山本浩史, 折野俊介, Yutaka Masuda, Tetsuya Kitagawa and 加藤逸夫 : 慢性血液透析前後における血中遊離型および硫酸抱合型カテコラミンの変動―心拍変動周波数解析との関係, 第42回日本心臓病学会, Sep. 1994. (Summary) 血液透析前後で遊離型·硫酸抱合型カテコラミンの変動を検討した．透析後，心拍変動解析にて交感神経低下と抱合型カテコラミン増加がみられた．
154.	Masahiro Nomura, Yutaka Nakaya, 岸史子 and Ken Saito : 僧帽弁逸脱における心室遅延電位―心拍変動による影響, 第42回日本心臓病学会, Sep. 1994. (Summary) 僧帽弁逸脱では心室性不整脈が多くみられる．本症における心室遅延電位は心拍変動による影響を受け，運動負荷時には陰性化する．
155.	Masahiro Nomura, Yutaka Nakaya, 渡部克介, 岸史子, Ken Saito, 三好宏和, 西條哲也, 大木崇 and Susumu Ito : L-アルギニン静脈注射による自律神経活動の影響―心拍変動解析による検討, 第39回循環器負荷研究会, Aug. 1994. (Summary) L-アルギニンから一酸化窒素NOが合成される．L-アルギニンの静脈注射により，心拍変動解析を行うと交感神経活動が亢進した．
156.	Masahiro Nomura, Yutaka Nakaya, 岸史子, Ken Saito and Susumu Ito : 心磁図法による心房性再分極波(Ta波)の検討, 第9回日本生体磁気学会, Jun. 1994. (Summary) 心臓磁界は位置分解能が良好で，心電図で検出できない起電力を捉えられる．心房性再分極波は，心磁図法にて良好に検出可能であった．
157.	西條哲也, Toshiya Okahisa, Seisuke Okamura, Hiroshi Shibata, Hirohito Honda, Ichiro Shimizu, 折野俊介, Masahiro Nomura, Ken Saito and Susumu Ito : 高血圧合併消化性潰瘍の自律神経機能の検討, 第11回四国消化性潰瘍研究会, Jun. 1994. (Summary) 高血圧症では交感神経活動の亢進と副交感神経活動の低下がみられ消化性潰瘍は合併しにくいが，高血圧合併潰瘍例では，副交感神経活動の亢進がみられた．
158.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 生藤博行, 山本克人, Akiyoshi Nishikado, 坂東重信 and Susumu Ito : 心筋梗塞症における梗塞および心筋虚血ベクトルの位置関係ー心臓磁界測定による電流源の位置推定ー, 第58回日本循環器学会学術集会, Mar. 1994. (Summary) 心磁図法に心電図同期MRI画像を併用して心筋梗塞症における初期QRSベクトルの位置および心室再分極ベクトルの電流源の位置関係について検討した．
159.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子 and Susumu Ito : 自律神経の房室伝導時間への関与ー体表面加算平均心電図法を用いた検討ー, 第58回日本循環器学会学術集会, Mar. 1994. (Summary) P波同期とQRS同期の平均加算化心電図を用いて，PR間隔の変動と自律神経活動の関与について検討した．交感神経の亢進ではPR間隔の変動は少ない．
160.	西條哲也, Masahiro Nomura, Ken Saito and Susumu Ito : 消化性潰瘍例の心拍スペクトル解析による自律神経機能の検討, 第30回日本臨床生理学会総会, Oct. 1993. (Summary) 消化性潰瘍では，自律神経異常がその成因の一つと考えられている．心拍変動解析を施行して夜間のLF/HF比およびHF値の亢進がみられた．
161.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子 and Susumu Ito : 僧帽弁逸脱における血中遊離型および硫酸抱合型カテコラミンの変動ー自律神経異常との関連性ー, 第30回日本臨床生理学会総会, Oct. 1993. (Summary) 僧帽弁逸脱は，カテコラミンを抱合型として非活性体として蓄積しており，運動負荷等のストレス時に活性体の遊離型となって自律神経異常をおこす．
162.	Masahiro Nomura, Ken Saito, Yutaka Nakaya, 岸史子 and Susumu Ito : 僧帽弁逸脱における心拍変動スペクトルの検討ー運動負荷時の自律神経活動, 第41回日本心臓病学会, Oct. 1993. (Summary) 自律神経障害を高率に合併する僧帽弁逸脱で運動負荷時の自律神経活動を心拍変動スペクトルで検討すると，運動によるLF/HFの異常高値がみられた．
163.	Yutaka Nakaya, Masahiro Nomura, 岸史子, 三好宏和, 渡部克介, Ken Saito, 山本克人, 生藤博行, 坂東重信 and Akiyoshi Nishikado : ソタロール，E-4031，MS-551の内向き整流K電流に対する作用, 第10回日本心電学会, Sep. 1993. (Summary) ソタロール，E-4031，MS-551の内向き整流K電流をpatch clamp法で検討した．Kチャンネルの作用は一様でなく，各薬剤で異なった薬物効果が期待された．
164.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 坂東重信, Akiyoshi Nishikado, 山本克人, 生藤博行, 日浅芳一 and 相原令 : 心筋梗塞症の梗塞ベクトルの電流源の位置ー心磁図法による検討ー, 第10回日本心電学会, Sep. 1993. (Summary) 心筋梗塞症における初期ベクトルの信号源を心磁図法で推定した．初期ベクトルは，梗塞部位には存在しなく，残存心筋により形成されていると思われた．
165.	Masahiro Nomura, 大木崇, Ken Saito, Yutaka Nakaya, 岸史子, 三好宏和, Tomotsugu Tabata, 井内新, 佐々木美和, 福田信夫 and Susumu Ito : 僧帽弁逸脱における運動負荷時の心拍変動スペクトルの検討, 第37回循環器負荷研究会, Aug. 1993. (Summary) 僧帽弁逸脱は交感神経機能が亢進しているとの報告がある．運動負荷時の心拍変動解析を施行し，交感神経活動の異常がみられた．
166.	Masahiro Nomura, 西條哲也, 岸史子, 三好宏和, Ken Saito, Yutaka Nakaya, 大木崇 and Susumu Ito : 肝硬変患者における自律神経機能ー体表面平均加算化心電図法を用いた検討, 第12回心脈管研究会, Jul. 1993. (Summary) 肝硬変症は，NOの増加によるhyperdynamic stateがみられる．肝硬変症における心電図PR間隔の変動を体表面平均加算化心電図法により検討した．
167.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 三好宏和, Susumu Ito, 田村逸郎, 和田昌夫 and 藤田智 : 心磁図法によるPベクトルの位置推定, 第42回ベクトル心電図研究会(心電現象研究会), Jun. 1993. (Summary) 心磁図法では，三次元的に信号源の位置が計算できる．本研究では，心磁図P波を加算平均することにより，心房興奮起電力の信号源を推定可能であった．
168.	Yutaka Nakaya, Masahiro Nomura, 岸史子, Ken Saito, Akiyoshi Nishikado, 坂東重信 and Susumu Ito : 心室性不整脈の発生源の推定ー心電図と心磁図の比較, 第8回日本生体磁気学会, Jun. 1993. (Summary) 心室性不整脈の発生源を体表面電位図と磁界分布図からの三次元的位置を比較した．両手法の推定位置は類似しており，心磁図法の臨床的有用性が示唆された．
169.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 三好宏和, Akiyoshi Nishikado, 坂東重信, Susumu Ito, 和田昌夫, 藤田智 and 田村逸郎 : SQUIDを用いた心房興奮伝播のMRI画像上の表示, 第8回日本生体磁気学会, Jun. 1993. (Summary) 心磁図法を用いて心房興奮電流の位置推定を行い，心電図同期MRI画像にマッピングした．P波の前半部分は右房に後半部分は左房に電流源が位置した．
170.	Yutaka Nakaya, Ken Saito, Masahiro Nomura, 三好宏和, 渡部克介, 岸史子, Akiyoshi Nishikado, 坂東重信 and Susumu Ito : ATP感受性KチャンネルのATP感受性よりみたK-channel opener, pinacidilの臓器特異性, 第57回日本循環器学会学術集会, Mar. 1993. (Summary) イヌ冠動脈，心室筋，Purkinje線維で検討した．Pinacidilの有効濃度は組織により異なり，一因としてKATPの活性化状態とATPチャンネル抑制の差が考えられた．
171.	岸史子, Ken Saito, Masahiro Nomura, 三好宏和, 渡部克介, Yutaka Nakaya, Akiyoshi Nishikado, 坂東重信 and Susumu Ito : 培養ブタ冠動脈平滑筋細胞のCa²⁺依存性KチャンネルのプロテインキナーゼCによる阻害, 第57回日本循環器学会学術集会, Mar. 1993. (Summary) ブタ冠動脈平滑筋細胞で検討した．活性化PKCは，Kcaのチャンネル蛋白のリン酸化をもたらし直接Kcaの開口を阻害し，血管の収縮に関与していると考えられた．
172.	Yutaka Nakaya, 岸史子, Ken Saito, Masahiro Nomura, 三好宏和, 渡部克介, Akiyoshi Nishikado and 坂東重信 : III群抗不整脈薬の単一内向き整流K電流(iK1)に対する作用, 第57回日本循環器学会学術集会, Mar. 1993. (Summary) モルモット心室筋でイオンチャンネルを評価した．III群不整脈のKチャンネルの作用は一様でなく，チャンネルの特異性の差により薬物効果が期待される．
173.	三好宏和, 渡部克介, Masahiro Nomura, Ken Saito, Yutaka Nakaya and Susumu Ito : ブタ冠動脈平滑筋におけるATP感受性Kチャンネルに対するcAMPの作用, 第57回日本循環器学会学術集会, Mar. 1993. (Summary) KATPチャンネルは生理的条件下で活性をもち，膜静止電位に寄与しており，cAMPもその調節に関与し，血管のトーヌスの調整に関わっていると考えられた．
174.	渡部克介, 三好宏和, Masahiro Nomura, Ken Saito, Yutaka Nakaya and Susumu Ito : 培養ブタ冠動脈平滑筋細胞のCa²⁺依存性Kチャンネル(KCa)のcAMPによる活性化機序, 第57回日本循環器学会学術集会, Mar. 1993. (Summary) cAMPによるKCaの活性化には2つの経路(cAMPの直接作用とPKAを介する系)が存在し，静止時および細胞収縮時に両経路が関与すると考えられた．
175.	Masahiro Nomura, Ken Saito, Yutaka Nakaya, 岸史子, 三好宏和, 渡部克介, 大木崇 and Susumu Ito : 僧帽弁逸脱における自律神経機能の日内変動ー心拍スペクトル解析による検討ー, 第57回日本循環器学会学術集会, Mar. 1993. (Summary) 僧帽弁逸脱における自律神経機能の日内変動を心拍スペクトル解析により検討した．僧帽弁逸脱は自律神経サーカディアンリズムの障害がみられた．
176.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 岸史子, 越智由恵, 三好宏和, Susumu Ito, 久保雅宏 and 松岡優 : 糖尿病における心室遅延電位:Vector Magnitude法および高速フーリエ変換による心筋障害の早期診断, 第57回日本循環器学会学術集会, Mar. 1993. (Summary) 糖尿病における心室遅延電位をVector Magnitude法·高速フーリエ変換により検討した．糖尿病で心室遅延電位あり，障害の早期診断が可能であった．
177.	Yutaka Nakaya, Masahiro Nomura, 岸史子, Ken Saito and 森博愛 : 心磁図の臨床応用ー心室性不整脈の発生源の推定, マグネティックス研究会, Mar. 1993. (Summary) 心磁図法は電流源の推定ができる．心室性不整脈の最早期興奮部位の電流源を推定は，カーテーテル·アブレーションの術前評価に有用と考えられる．
178.	西條哲也, Masahiro Nomura, Ken Saito, Yutaka Nakaya, 岸史子, 大木崇, Susumu Ito, 篠原尚典, 山本浩史, 折野俊介, 大喜田義雄 and 小路純子 : 内視鏡検査時の自律神経機能の評価ー心拍変動解析による検討ー, 第38回循環器負荷研究会, Feb. 1993. (Summary) 内視鏡検査により循環動態がいかに変動するか，心拍変動解析により検討した．検査中には，副交感神経活動の指標であるHF値が低下していた．
179.	西條哲也, Ken Saito, 田村秀作, 福田保, 篠原尚典, 坂東政司, 篠原正幸, 折野俊介, 谷憲治, 矢野章夫, Masahiro Nomura and Susumu Ito : 消化性潰瘍におよぼすストレスの影響, 第29回日本臨床生理学会総会, Oct. 1992. (Summary) 消化性潰瘍において心拍変動解析により自律神経活動を観察した．夜間の副交感神経および交感神経活動が亢進しており，潰瘍とストレスの関連性が示唆された．
180.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 田村逸郎, 和田昌夫 and 藤田智 : SQUIDを用いた心房興奮部位の三次元表示-心電図同期MRI画像上への電流dipoleの表示, 第40回日本心臓病学会, Oct. 1992. (Summary) SQUIDを用いた心房興奮部位の三次元表示をおこなった．計算された電流源を心電図同期MRI画像上へ表示すると，右房から左房への興奮がみられた．
181.	Yutaka Nakaya, Masahiro Nomura, Ken Saito, 坂東重信 and TJ Campbell : ピナシディルの心筋活動電位持続時間短縮作用，冠動脈拡張作用, 第9回日本心電学会学術集会, Oct. 1992. (Summary) ピナシディルの冠動脈，心室筋，プルキンエ線維に対する有効濃度は異なり，高濃度でKチャンネル開口作用以外の血管拡張作用を有すると示唆された．
182.	Masahiro Nomura, Yutaka Nakaya, Ken Saito, 坂東重信, Akiyoshi Nishikado, 日浅芳一 and 相原令 : Magnetic Source Image法による心室中隔ベクトルの位置推定, 第9回日本心電学会学術集会, Oct. 1992. (Summary) 心磁図で電流源が推定可能でMagnetic Source Image法と呼ばれる．本法で心室中隔ベクトルの位置推定は誤差少なく計算できた．
183.	Yutaka Nakaya, Ken Saito, Masahiro Nomura, 三好由貴子 and Tetsuzo Wakatsuki : 血管平滑筋カリウム電流と収縮·弛緩-血管作動物質の効果-, 第11回心脈管研究会, Aug. 1992. (Summary) 培養血管平滑筋細胞では，ATP感受性Kチャネル(KATP)が血管のトーヌスの調節に関与し，またこの抑制により，血管が収縮することを明らかにした．
184.	Masahiro Nomura, 大木崇, Tomotsugu Tabata, 三好由貴子, 井内新, 清重浩一, 藤本卓, Ken Saito, 福田信夫, Yutaka Nakaya, Susumu Ito, 吉栖正典, Yutaka Masuda, Tetsuya Kitagawa and 加藤逸夫 : 僧帽弁逸脱における血中遊離型および硫酸抱合型カテコラミンの変動, 第35回循環器負荷研究会, Aug. 1992. (Summary) 僧帽弁逸脱の遊離型と硫酸抱合型カテコラミンの変動をトレッドミル運動負荷前後で比較した．本症は，抱合型のカテコラミンが蓄えられている．
185.	Tetsuzo Wakatsuki, Yutaka Nakaya, 三好由貴子, Masahiro Nomura, Ken Saito and Susumu Ito : 冠動脈血管平滑筋の2種のKチャンネルに対するVasopressinの作用, 第56回日本循環器学会総会, Mar. 1992. (Summary) Vasopressinには，ATP感受性KチャンネルとCa2+依存性Kチャンネルの2種類のKチャンネルに対し異なる作用を持つ．
186.	Masahiro Nomura, Yutaka Nakaya, 三好由貴子, Tetsuzo Wakatsuki, Ken Saito, Akiyoshi Nishikado, 浜井一人, 坂東重信, Susumu Ito, 日浅芳一 and 相原令 : 心室頻拍およびWPW症候群の心室最早期興奮部位の推定-心臓磁界およびMRIを用いた部位推定-, 第56回日本循環器学会総会, Mar. 1992. (Summary) 心臓磁界を用いて，心室頻拍およびWPW症候群の心室最早期興奮部位をMRI画像上に重畳すると心臓カテーテルや体表面電位図所見と一致した．

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1.	喜多知子, 中村観善, 磯部淳一, Masanobu Fujii, Ken Saito, Noriko Kagawa, Chieko Matsuura, Mayumi Umeno, Eiji Hosoi, 百瀬圭三, 大西敏男, 吉野富雄, 長澤秀行, 岡三希生 and 姫野國祐 : 医療技術短期大学部衛生技術学科，臨床検査技師学校及び大学衛生学科における基礎及び臨床専門科目の実習に関する実態調査, 平成2年度教育研究方法等改善経費研究成果報告書, 131-133, Mar. 1991.

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血管平滑筋細胞のKチャネルと血管の収縮・弛緩機構 (Project/Area Number: 03670454 )
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Professor Emeritus : Saito, Ken

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