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研究活動

専門分野

研究テーマ

著書・論文

著書:

1. 佐藤 光信, 梁川 哲雄, 吉田 秀夫, 竹川 佳宏 :
癌治療学 下, --- 第II編 器官別療法 15. 歯槽歯肉癌 d. 化学療法 ---,
日本臨牀社, 東京, 1989年1月.
2. 佐藤 光信, 梁川 哲雄, 吉田 秀夫, 竹川 佳宏 :
癌治療学 下, --- 第II編 器官別療法 15. 歯槽歯肉癌 e. 集学的療法 ---,
日本臨牀社, 東京, 1989年1月.
3. 佐藤 光信, 梁川 哲雄, 吉田 秀夫, 竹川 佳宏 :
癌治療学 下, --- 第IV編 小児悪性腫瘍ー治療の特異性ー 2. 小児固形腫瘍 13) 歯槽歯肉腫瘍 ---,
日本臨牀社, 東京, 1989年1月.
4. Mitsunobu Sato, Yoshio Hayashi and Hideo Yoshida :
Immunopharmacological aspects of OK-432 in humans, --- Effect of immuno-therapy with streptococcal preparation,OK-432, on the peripheral killer lymphocyte population in patients with head and neck cancer ---,
1986.
5. Mitsunobu Sato, Yoshio Hayashi and Hideo Yoshida :
Recent Advances in Chemotherapy, --- Effect of postoperative immunotherapy with streptpcoccal preparation OK-432 on different immunologic parameters in patients with head and neck cancer ---,
1985.

学術論文(審査論文):

1. Daisuke Uchida, Tomitaro Onoue, Yoshifumi Tomizuka, Nasima Mila Begum, Yoshihiro Miwa, Hideo Yoshida and Mitsunobu Sato :
Involvement of an autocrine stromal cell derived factor-1/CXCR4 system on the distant metastasis of human oral squamous cell carcinoma.,
Molecular Cancer Research : MCR, Vol.5, No.7, 685-694, 2007.
(DOI: 10.1158/1541-7786.MCR-06-0368,   PubMed: 17634424)
2. Masayuki Azuma, Yuki Ashida, Tetsuya Tamatani, Katsumi Motegi, Natsumi Takamaru, Naozumi Ishimaru, Yoshio Hayashi and Mitsunobu Sato :
Cepharanthin,a biscoclaurine alkaloid,prevents destruction of acinar tissues in murine Sjogren's syndrome.,
The Journal of Rheumatology, Vol.33, No.5, 912-920, 2006.
(PubMed: 16652422)
3. Naonobu Tanaka, Mamoru Okasaka, Youko Ishimaru, Yoshihisa Takaishi, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa, Sharif Uddin Ahmed, L. Mark Consentino and Kuo-Hsiung Lee :
Biyouyanagin A, an Anti-HIV Agent from Hypericum chinense L. var. salicifolium,
Organic Letters, Vol.7, No.14, 2997-2999, 2005.
(DOI: 10.1021/ol050960w,   PubMed: 15987189)
4. Tetsuya Oshikawa, Masato Okamoto, Sharif U. Ahmed, Sachiko Furuichi, Tomoyuki Tano, Akiko Sasai, Shin Kan, Soko Kasai, Yoshihiro Uto, Hideko Nagasawa, Hitoshi Hori and Mitsunobu Sato :
TX-1877, a bifunctional hypoxic cell radiosensitizer, enhances anticancer host response: immune cell migration and nitric oxide production.,
International Journal of Cancer, Vol.116, No.4, 571-578, 2005.
(DOI: 10.1002/ijc.21101,   PubMed: 15825172)
5. Ai Suga, Yoshihisa Takaishi, Hiroyuki Nakagawa, Tadashi Iwasa, Mitsunobu Sato and Masato Okamoto :
Chemical Constituents from Fruits and Seeds of Myrica rubra (Myricaceae),
Natural Medicines, Vol.59, No.2, 70-75, 2005.
(CiNii: 1520572358490352768,   Elsevier: Scopus)
6. Takaaki Sagawa, Yoshihisa Takaishi, Yoshinori Fujimoto, Carmenza Duque, Coralia Osorio, Freddy Ramos, Garzon Cristina, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa and Sharif Uddin Ahmed :
Cyclobutane Dimers from the Colombian Medicinal Plant Achyrocline bogotensis,
Journal of Natural Products, Vol.68, No.4, 502-505, 2005.
(DOI: 10.1021/np040187y,   PubMed: 15844937)
7. 玉谷 哲也, 東 雅之, 茂木 勝美, 芦田 有紀, 髙丸 菜都美, 板東 髙志, 吉田 秀夫, 佐藤 光信 :
口腔扁平上皮癌細胞に対するセファランチンによる放射線感受性増強作用 : 分子標的NF-κBの抑制,
日本口腔科学会雑誌, Vol.54, No.2, 230-236, 2005年.
(DOI: 10.11277/stomatology1952.54.230,   CiNii: 1520290883462556800)
8. Katsumi Motegi, Masayuki Azuma, Tetsuya Tamatani, Yuki Ashida and Mitsunobu Sato :
Expression of aquaporin-5 in and fluid secretion from immortalized human salivary gland ductal cells by treatment with 5-aza-2'-deoxycytidine: a possibility for improvement of xerostomia in patients with Sjögren's syndrome.,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.85, No.3, 342-353, 2005.
(DOI: 10.1038/labinvest.3700234,   PubMed: 15640830,   Elsevier: Scopus)
9. Hiroyuki Nakagawa, Yoshihisa Takaishi, Yoshinori Fujimoto, Carmenza Duque, Cristina Garzon, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa and Sharif Uddin Ahmed :
Chemical Constituents from the Colombian Medicinal Plant Maytenus laevis,
Journal of Natural Products, Vol.67, No.11, 1919-1924, 2004.
(DOI: 10.1021/np040006s,   PubMed: 15568791)
10. Daisuke Uchida, Nasima Mila Begum, Ammar Almofti, Hitoshi Kawamata, Hideo Yoshida and Mitsunobu Sato :
Frequent Down-regulation of 14-3-3 sigma protein and Hypermethylation of 14-3-3 sigma gene in Salivary Gland Adenoid Cystic Carcinoma,
British Journal of Cancer, Vol.91, No.6, 1131-1138, 2004.
(DOI: 10.1038/sj.bjc.6602004,   PubMed: 15292943,   Elsevier: Scopus)
11. Masato Okamoto, Sachiko Furuichi, Yasuhiko Nishioka, Tetsuya Oshikawa, Tomoyuki Tano, Sharif Uddin Ahmed, Kiyoshi Takeda, Shizuo Akira, Yoshiki Ryoma, Yoichiro Moriya, Motoo Saito, Saburo Sone and Mitsunobu Sato :
Expression of Toll-Like Receptor 4 on Dendritic Cells Is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal Preparation,
Cancer Research, Vol.64, No.15, 5461-5470, 2004.
(DOI: 10.1158/0008-5472.CAN-03-4005,   PubMed: 15289356)
12. 内田 大亮, 玉谷 哲也, 富塚 佳史, 大江 剛, 吉田 秀夫, 佐藤 光信 :
難治性下顎骨骨髄炎を呈したpycnodysostosisの治療経過とカテプシンK遺伝子の変異解析,
日本口腔外科学会雑誌, Vol.50, No.7, 415-421, 2004年.
(DOI: 10.5794/jjoms.50.415,   CiNii: 1390282681509272576)
13. Ammar Almofti, Daisuke Uchida, Nasima Mila Begum, Yoshifumi Tomizuka, Hiroki Iga, Hideo Yoshida and Mitsunobu Sato :
The clinicopathological significance of the expression of CXCR4 protein in oral squamous cell carcinoma,
International Journal of Oncology, Vol.25, No.1, 65-71, 2004.
(PubMed: 15201990)
14. Tetsuya Tamatani, Masayuki Azuma, Y Ashida, Katsumi Motegi, R Takashima, Koji Harada, S Kawaguchi and Mitsunobu Sato :
Enhanced radiosensitization and chemosensitization in NF-κB-suppressed human oral cancer cells via the inhibition of g-irradiation- and 5-FU-induced production of IL-6 and IL-8,
International Journal of Cancer, Vol.108, No.6, 912-921, 2004.
(DOI: 10.1002/ijc.11640,   PubMed: 14712497)
15. Daisuke Uchida, Nasima Mila Begum, Yoshifumi Tomizuka, Takashi Bando, Ammar Almofti, Hideo Yoshida and Mitsunobu Sato :
Acquisition of lymph node, but not distant metastatic potentials, by the over-expression of CXCR4 in human oral squamous cell carcinoma cells,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.84, No.12, 1538-1546, 2004.
(Elsevier: Scopus)
16. Ko-ichi Nakashiro, Mila Nasima Begum, Daisuke Uchida, Hitoshi Kawamata, Satoru Shintani, Mitsunobu Sato and Hiroyuki Hamakawa :
Thiazolidinediones inhibit cell growth of human oral squamous cell carcinoma in vitro independent of peroxisome proliferator-activated receptor gamma,
Oral Oncology, Vol.39, No.8, 855-861, 2003.
(DOI: 10.1016/S1368-8375(03)00108-8,   PubMed: 13679209,   Elsevier: Scopus)
17. Daisuke Uchida, Nasima Mila Begum, Ammar Almofti, Koichi Nakashiro, Hitoshi Kawamata, Yoshihisa Tateishi, Hiroyuki Hamakawa, Hideo Yoshida and Mitsunobu Sato :
Possible role of stromal-cell-derived factor-1/CXCR4 signaling on lymph node metastasis of oral squamous cell carcinoma,
Experimental Cell Research, Vol.290, No.2, 289-302, 2003.
(DOI: 10.1016/S0014-4827(03)00344-6,   PubMed: 14567988,   CiNii: 1572543026627194880,   Elsevier: Scopus)
18. Mitsunobu Sato, Masayuki Azuma, Tetsuya Tamatani, Yuki Ashida, Rina Takashima and Koji Harada :
Cisplatin induces apoptosis in oral squamous carcinoma cells by the mitochondria-mediated but not the NF-kB-suppressed pathway,
Oral Oncology, Vol.39, No.3, 282-289, 2003.
(DOI: 10.1016/S1368-8375(02)00116-1,   PubMed: 12618201)
19. 佐竹 秀太, 高木 豊明, 堀内 信也, 横関 雅彦, 藤澤 健司, 宮本 洋二, 伊賀 弘起, 吉田 秀夫, 長山 勝, 佐藤 光信, 森山 啓司 :
徳島大学歯学部附属病院矯正歯科における顎変形症患者の臨床統計学的検討,
四国歯学会雑誌, Vol.15, No.2, 257-262, 2003年.
20. Tetsuya Oshikawa, Masato Okamoto, Go Ohe, Sachiko Furuichi, Hidetomo Nishikawa, Sharif Ahmed Uddin, Hideo Yoshida, Yoichiro Moriya, Shuzo Matsubara, Yoshiki Ryoma, Motoo Saito and Mitsunobu Sato :
Anti-tumor immune response induced by the fractions derived from OK-432, a streptococcal preparation, by using a monoclonal antibody TS-2 that neutralizes the interferon-gamma-inducing activity of OK-432: comparison between the TS-2-binding and TS-2-unbinding fraction.,
International Immunopharmacology, Vol.3, No.5, 643-655, 2003.
(DOI: 10.1016/S1567-5769(02)00274-6,   PubMed: 12757734,   Elsevier: Scopus)
21. Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa, Tomoyuki Tano, Go Ohe, Sachiko Furuichi and Hidetomo Nishikawa :
Involvement of Toll-like receptor 4 signaling in interferon-γ production and anti-tumor effect by a streptococcal agent OK-432.,
Journal of the National Cancer Institute, Vol.95, No.4, 316-326, 2003.
(DOI: 10.1093/jnci/95.4.316,   PubMed: 12591988)
22. Mitsunobu Sato, Masato Okamoto, Go Ohe, Sachiko Furuichi, Hidetomo Nishikawa, Tetsuya Oshikawa, Tomoyuki Tano, SU Ahmed and Hideo Yoshida :
Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent, in athymic nude mice bearing human salivary adenocarcinoma: Role of natural killer cells,
Anticancer Research, Vol.22, No.6A, 3229-3240, 2002.
(PubMed: 12530069,   Elsevier: Scopus)
23. Mitsunobu Sato, Koji Harada, Hideo Yoshida and Supriatno :
Low p27Kip1 expression is associated with poor prognosis in oral squamous cell carcinoma.,
Anticancer Research, Vol.22, No.5, 2985-2989, 2002.
(PubMed: 12530030,   Elsevier: Scopus)
24. MO Hoque, Hitoshi Kawamaha, Koh-ichi Nakashiro, Fumie Omotehara, Satoshi Hino, Daisuke Uchida, Koji Harada, NM Begum, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori :
Dysfunction of the p53 tumor suppressor pathway in head and neck cancer,
International Journal of Oncology, Vol.21, No.1, 119-126, 2002.
(PubMed: 12063558,   Elsevier: Scopus)
25. Masayuki Azuma, Keiko Aota, Tetsuya Tamatani, Katsumi Motegi, Yuki Ashida, Yoshio Hayashi, Mitsunobu Sato and Mitsunobu Sato :
Suppression of TNF-α-induced MMP 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of NFκB, --- A possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjögren's syndrome patients ---,
Arthritis and Rheumatism, Vol.46, No.6, 1585-1594, 2002.
(DOI: 10.1002/art.10315,   PubMed: 12115190)
26. Satoshi Hino, Hitoshi Kawamaha, Fumie Omotehara, Daisuke Uchida, Yoshihiro Miwa, NM Begum, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori :
Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells,
Biochemical and Biophysical Research Communications, Vol.292, No.4, 957-963, 2002.
(DOI: 10.1006/bbrc.2002.6776,   PubMed: 11944908,   Elsevier: Scopus)
27. Satoshi Hino, Hitoshi Kawamata, Fumie Omotehara, Daisuke Uchida, NM Begum, Hideo Yoshida and Mitsunobu Sato :
Leucine zipper structure of TSC-22 (TGF-b stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells,
Oncology Reports, Vol.9, No.2, 371-374, 2002.
(PubMed: 11836610,   Elsevier: Scopus)
28. Mila Nasima Begum, Ko-ichi Nakashiro, Hitoshi Kawamata, Daisuke Uchida, Satoru Shintani, Yoji Ikawa, Mitsunobu Sato and Hiroyuki Hamakawa :
Expression of peroxisome proliferator-activated receptor _ and the growth inhibitory effect of its synthetic ligands in human salivary gland cancer cell lines,
International Journal of Oncology, Vol.20, No.3, 599-605, 2002.
(PubMed: 11836575,   Elsevier: Scopus)
29. Mitsunobu Sato, Keiko Aota, Masayuki Azuma, Tetsuya Tamatani, Tuyoshi Yamashita and Yuki Ashida :
Stable inhibition of NF-kB in salivary gland cells does not enhance sensitivity to TNF-a-induced apoptosis due to upregulation of TRAF-1 expression,
Experimental Cell Research, Vol.276, No.1, 111-119, 2002.
(DOI: 10.1006/excr.2002.5515,   PubMed: 11978013)
30. 佐藤 光信, 岡本 正人, 田野 智之, 大江 剛, 古市 幸子, 西川 英知, 吉田 秀夫 :
頭頸部癌患者におけるToll-like receptor 4およびMD-2遺伝子発現:癌免疫療法剤OK-432の分子標的,
日本口腔科学会雑誌, Vol.51, No.5, 340-348, 2002年.
(CiNii: 1390001206436030720)
31. 佐藤 光信, 岡本 正人, 古市 幸子, 大江 剛, 西川 英知, 田野 智之, 吉田 秀夫 :
OK-432有効成分によるToll-Like Receptor 4を介した樹状細胞活性化,
日本口腔科学会雑誌, Vol.52, No.2, 51-62, 2002年.
(CiNii: 1390001206436047104)
32. Tetsuya Tamatani, Masayuki Azuma, Aota K, Yamashita T, Takashi Bando and Mitsunobu Sato :
Enhanced IkB kinase activity is responsible for the augmented activity of NF-_B in human head and neck carcinoma cells,
Cancer Letters, Vol.171, No.2, 165-172, 2001.
(DOI: 10.1016/S0304-3835(01)00611-5,   PubMed: 11520600,   Elsevier: Scopus)
33. MO Hoque, Hitoshi Kawamaha, Koh-ichi Nakashiro, Fumie Omotehara, Yasuhiro Shinagawa, Satoshi Hino, NM Begum, Daisuke Uchida, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori :
Dihydropyrimidine dehydrogenase mRNA level correlates with the response to 5-fluorouracil-based chemo-immuno-radiation therapy in human oral squamous cell cancer,
International Journal of Oncology, Vol.19, No.5, 953-958, 2001.
(PubMed: 11604993,   Elsevier: Scopus)
34. Daisuke Uchida, Hitoshi Kawamata, Fumie Omotehara, Koichi Nakashiro, Tetsuo Kimura-Yanagawa, Satoshi Hino, Nasima Mila Begum, MO Hoque, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori :
Role of HGF/C-MET system in invasion and metastasis of oral squamous cell carcinoma cells in vitro and its clinical significance,
International Journal of Cancer, Vol.93, No.4, 489-496, 2001.
(DOI: 10.1002/ijc.1368,   PubMed: 11477552,   Elsevier: Scopus)
35. Daisuke Uchida, Hitoshi Kawamata, Koichi Nakashiro, Fumie Omotehara, Satoshi Hino, MO Hoque, Nasima Mila Begum, Hideo Yoshida, Mitsunobu Sato and Takahiro Fujimori :
Low-dose retinoic acid enhances in vitro invasiveness of human oral squamous-cell-carcinoma cell lines by up-regulation of tissue-type plasminogen activator and activation of pro-matrix metalloproteinases,
British Journal of Cancer, Vol.85, No.1, 122-128, 2001.
(DOI: 10.1054/bjoc.2001.1862,   PubMed: 11437413,   Elsevier: Scopus)
36. 玉谷 哲也, 東 雅之, 吉田 秀夫, 佐藤 光信 :
口腔癌細胞への変異型IkB-a遺伝子導入による抗血管新生作用を介した腫瘍増殖抑制効果,
口腔組織培養学会誌, Vol.10, No.2, 45-54, 2001年.
37. Satoshi Hino, Hitoshi Kawamata, Daisuke Uchida, Fumie Omotehara, Yoshihiro Miwa, Mila Nasima Begum, Hideo Yoshida and Mitsunobu Sato :
Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator,
Biochemical and Biophysical Research Communications, Vol.278, No.3, 659-664, 2000.
(DOI: 10.1006/bbrc.2000.3840,   PubMed: 11095965,   Elsevier: Scopus)
38. Masato Okamoto, Kenji Hiura, Go Ohe, Yasuo Oba, Kunihiro Terai, Tetsuya Oshikawa, Sachiko Furuichi, Hidetomo Nishikawa, Keiji Moriyama, Hideo Yoshida and Mitsunobu Sato :
Mechanism for bone invasion of oral cancer cells mediated by interleukin-6 in vitro and in vivo,
Cancer, Vol.89, No.9, 1966-1975, 2000.
(DOI: 10.1002/1097-0142(20001101)89:9<1966::AID-CNCR13>3.0.CO;2-R,   PubMed: 11064354,   Elsevier: Scopus)
39. Masayuki Azuma, Tetsuya Tamatani, Katsumi Motegi, Keiko Aota, Tsuyoshi Yamashita, Kouji Harada, Yoshio Hayashi and Mitsunobu Sato :
Suppression of tumor necrosis factor-a-induced matrix metalloproteinase-9-production by introduction of a super-repressor form of IkB-cDNA into immotalized human salivary gland acinar cells,
Arthritis and Rheumatism, Vol.43, No.8, 1756-1767, 2000.
(DOI: 10.1002/1529-0131(200008)43:8<1756::AID-ANR12>3.0.CO;2-H,   PubMed: 10943866,   Elsevier: Scopus)
40. Keiko Aota, Masayuki Azuma, Tsuyoshi Yamashita, Testuya Tamatani, Katsumi Motegi, Naozumi Ishimaru, Yoshio Hayashi and Mitsunobu Sato :
5-Fluorouracil Induces Apoptosis through the Suppression of NF-κB Activity in Human Salivary Gland Cancer Cells,
Biochemical and Biophysical Research Communications, Vol.273, No.3, 1168-1174, 2000.
(DOI: 10.1006/bbrc.2000.3072,   PubMed: 10891390)
41. Fumie Omotehara, Daisuke Uchida, Satoshi Hino, NM Begum, Hideo Yoshida, Mitsunobu Sato and Hitoshi Kawamata :
In vivo enhancement of chemosensitivity of human salivary gland cancer cells by overexpression of TGF-beta stimulated clone-22,
Oncology Reports, Vol.7, No.4, 737-740, 2000.
(DOI: 10.3892/or.7.4.737,   PubMed: 10854535,   Elsevier: Scopus)
42. Daisuke Uchida, Hitoshi Kawamata, Fumie Omotehara, Yoshihiro Miwa, Satoshi Hino, Mila Nasima Begum, Hideo Yoshida and Mitsunobu Sato :
Over-expression of TSC-22 (TGF-beta stimulated clone-22) markedly enhances 5-fluorouracil-induced apoptosis in a human salivary gland cancer cell line,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.80, No.6, 955-963, 2000.
(PubMed: 10879745,   Elsevier: Scopus)
43. 柳 久美子, 東 雅之, 佐藤 光信, 林 良夫 :
慢性GVHDにおける口腔粘膜·口唇腺の免疫組織化学的研究,
日本口腔粘膜学会雑誌, Vol.6, 62-68, 2000年.
44. Hitoshi Kawamata, Daisuke Uchida, Ko-ichi Nakashiro, Satoshi Hino, Fumie Omotehara, Hideo Yoshida and Mitsunobu Sato :
Haematogenous cytokeratin 20 mRNA as a predictive marker for recurrence in oral cancer patients,
British Journal of Cancer, Vol.80, No.3-4, 448-452, 1999.
(DOI: 10.1038/sj.bjc.6690377,   PubMed: 10408852,   Elsevier: Scopus)
45. Hitoshi Kawamata, Daisuke Uchida, Hamano Hironori, Tetsuo Kimura-Yanagawa, Ko-ichi Nakashiro, Satoshi Hino, Fumie Omotehara, Hideo Yoshida and Mitsunobu Sato :
Active-MMP2 in cancer cell nests of oral cancer patients: correlation with lymph node metastasis,
International Journal of Clinical Oncology, Vol.13, No.4, 699-704, 1998.
(DOI: 10.3892/ijo.13.4.699)
46. Koichi Nakashiro, Hitoshi Kawamata, Satoshi Hino, Daisuke Uchida, Yoshihiro Miwa, Hironori Hamano, Fumie Omotehara, Hideo Yoshida and Mitsunobu Sato :
Down-regulation of TSC-22 (transforming growth factor beta-stimulated clone 22) markedly enhances the growth of a human salivary gland cancer cell line in vitro and in vivo,
Cancer Research, Vol.58, No.3, 549-555, 1998.
(PubMed: 9458104,   Elsevier: Scopus)
47. Hitoshi Kawamata, Koh-ichi Nakashiro, Daisuke Uchida, Satoshi Hino, Fumie Omotehara, Hideo Yoshida and Mitsunobu Sato :
Induction of TSC-22 by treatment with a new anti-cancer drug, vesnarinone, in a human salivary gland cancer cell,
British Journal of Cancer, Vol.77, No.1, 71-78, 1998.
(PubMed: 9459148,   Elsevier: Scopus)
48. Masayuki Azuma, Katsumi Motegi, Keiko Aota, Yoshio Hayashi and Mitsunobu Sato :
Role of cytokines in the destruction of acinar structure in Sjogren's syndrome salivary glands,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.77, No.3, 269-280, 1997.
49. Mitsunobu Sato, Koji Harada, Hideo Yoshida, Yura Yoshiaki, Masayuki Azuma, Hiroki Iga, Takashi Bando, Kawamata Hitoshi and Yoshihiro Takegawa :
Therapy for oral squamous cell carcinoma by tegafur and streptococcal agent OK-432 in combination with radiotherapy : Association of the therapeutic effect with differentiation and apoptosis in the cancer cells,
Apoptosis, Vol.2, No.2, 227-238, 1997.
(DOI: 10.1023/a:1026428918301,   PubMed: 14646559,   Elsevier: Scopus)
50. Hitoshi Kawamata, Ko-ichi Nakashiro, Daisuke Uchida, Satoshi Hino, Koji Harada, Hideo Yoshida and Mitsunobu Sato :
Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines,
International Journal of Cancer, Vol.70, No.1, 120-127, 1997.
(DOI: 10.1002/(SICI)1097-0215(19970106)70:1<120::AID-IJC18>3.0.CO;2-P,   PubMed: 8985100,   Elsevier: Scopus)
51. Masayuki Azuma, Katsumi Motegi, Keiko Aota, Yoshio Hayashi and Mitsunobu Sato :
Role of cytokines of acinar structure in Sjogren's syndrome salivary glands,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.77, No.3, 269-280, 1997.
52. 細木 秀彦, 高木 康里, 岩崎 裕一, 上村 修三郎, 天眞 覚, 弘田 克彦, 河田 照茂, 吉田 秀夫, 佐藤 光信 :
外科的矯正手術患者の経時的観察, --- 手術後の下顎頭の形態変化と下顎頭の位置変化 ---,
歯科放射線, Vol.30, No.3, 185-191, 1990年.
53. Akiyo Nakahata, Hiroyo Deguchi, Tetsuo Yanagawa, Hideo Yoshida, Mitsunobu Sato and Yoshio Hayashi :
Coexpression of intermediate-sized filaments in sialadenoma papilliferum and other salivary gland neoplasms,
Journal of Oral Pathology & Medicine, Vol.19, No.7, 313-318, 1990.
54. Mitsunobu Sato, Hideo Yoshida, Kali Ryoli, Masato Okamoto, Hiroki Iga, Kawamata Hitoshi, Kobayasi Shosuke, Aladib Walid, Yanagawa Tetsuo and Yoshihiro Takegawa :
Induction of Bone Formation in an Adenoid Cystic Carcinoma of the Maxillary Sinus by Adoptive Immunotherapy Involving Intra-arterial Injection of Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 in Combination with Radiotherapy,
Journal of Biological Response Modifiers, Vol.9, No.3, 329-334, 1990.
(PubMed: 2166140,   Elsevier: Scopus)
55. 竹川 佳宏, 広瀬 千恵子, 原田 雅史, 徳山 教民, 田内 美紀, 橘川 薫, 梁川 哲雄, 吉田 秀夫, 佐藤 光信 :
歯槽歯肉癌の集学治療,
日本放射線腫瘍学会誌, Vol.01, No.02, 111-118, 1989年.
56. Yoshio Hayashi, Tetsuo Yanagawa, Hideo Yoshida, Masayuki Azuma, Toshinobu Nishida, Yoshiaki Yura and Mitsunobu Sato :
Expression of vasoactive intestinal polypeptide and amylase in a human parotid gland adenocarcinoma cell line in culture,
Journal of the National Cancer Institute, Vol.79, No.5, 1025-1037, 1987.
57. Yoshio Hayashi, Shinichi Nagamine, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura, Masayuki Azuma and Mitsunobu Sato :
Small cell undifferentiated carcinoma of the minor salivary gland containing exocrine, neuroendocrine, and squamous cells,
Cancer, Vol.60, No.7, 1583-1588, 1987.
58. Yoshio Hayashi, Hideo Yoshida, Shinichi Nagamine, Tetsuo Yanagawa, Yoshiaki Yura, Masayuki Azuma and Mitsunobu Sato :
Induction of cells with acinar cell phenotype including presence of intracellular amylase, --- Treatment with 12-O-tetradecanoyl-phorbol-13-acetate in a neoplastic human salivary intercalated duct cell line grown in athymic nude mice ---,
Cancer, Vol.60, No.5, 1000-1008, 1987.
59. Yoshio Hayashi, Toshinobu Nishida, Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura and Mitsunobu Sato :
Immunoreactive vasoactive intestinal polypeptide in acinic cell carcinoma of the parotid gland,
Cancer, Vol.60, No.5, 962-968, 1987.
60. Masayuki Azuma, Furumoto Nanayo, Kawamata Hitoshi, Hideo Yoshida, Yanagawa Tetsushi, Yura Yoshiaki, Yoshio Hayashi, Yoshihiro Takegawa and Mitsunobu Sato :
The relation of ras oncogene product p21 expression to clinocopathological status criteria and clinical outcome in squamous cell head and neck cancer,
The Cancer Journal, Vol.1, No.9, 375-380, 1987.
61. Tetsuo Yanagawa, Yoshio Hayashi, Hideo Yoshida, Yoshiaki Yura, Shinichi Nagamine, Takashi Bando and Mitsunobu Sato :
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen,
The American Journal of Pathology, Vol.124, No.3, 496-509, 1986.
62. 林 良夫, 吉田 秀夫, 西田 敏信, 永峰 伸一, 梁川 哲雄, 由良 義明, 佐藤 光信 :
耳下腺腺房細胞癌におけるVIPの発現,
医学のあゆみ, Vol.138, No.3, 207-208, 1986年.
63. Yoshio Hayashi, Haruhiko Saito, Shiro Saito, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura and Mitsunobu Sato :
Immunoreactive somatostatin in Warthin's tumor,
The American Journal of Pathology, Vol.123, No.2, 250-255, 1986.
64. Yoshio Hayashi, Yoshiaki Yura, Hideo Yoshida, Tetsuo Yanagawa and Mitsunobu Sato :
Development of allergic sialadenitis in mice immunized with mumps virus-infected submandibular salivary gland,
The American Journal of Pathology, Vol.123, No.2, 271-279, 1986.
65. Yoshio Hayashi, Hideo Yoshida, Furumoto Nanako, Yanagawa Tetsuo, Yura Yoshiaki, Yoshihiro Takegawa and Mitsunobu Sato :
Monoclonal antibody analysis of peripheral blood lymphocyte subpopulations in squamous cell head and neck cancer,
The Cancer Journal, Vol.1, No.1, 25-29, 1986.
66. Masayuki Azuma, Yoshio Hayashi, Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura, Akemichi Ueno and Mitsunobu Sato :
Emergence of differentiated subclones from a human salivary adenocarcinoma cell clone in culture after treatment with sodium butyrate,
Cancer Research, Vol.46, No.2, 770-777, 1986.
67. Tetsuo Yanagawa, Yoshio Hayashi, Toshinobu Nishida, Hideo Yoshida, Yoshiaki Yura, Masayuki Azuma and Mitsunobu Sato :
Immunohistochemical demonstration of carcinoembryonic antigen (CEA) on tissue sections from squamous cell head and neck cancer and plasma CEA levels of the patients,
International Journal of Oral and Maxillofacial Surgery, Vol.15, No.3, 296-306, 1986.
(PubMed: 3088159)
68. M Urata, Toshinobu Nishida, Yoshio Hayashi, Hideo Yoshida, N Furumoto, T Yanagawa, Y Yura and Mitsunobu Sato :
Immunoglobulin A circulating immune complexes in oral squamous cell cancer,
The Cancer Journal, Vol.1, No.2, 68-71, 1986.
69. Mitsunobu Sato, Hideo Yoshida, Yoshio Hayashi, Kenji Miyakami, Takashi Bando, Tetsuo Yanagawa, Yura Yura, Masayuki Azuma and Akemichi Ueno :
Expression of epidermal growth factor and transforming growth factor-beta in human salivary gland adenocarcinoma cell line,
Cancer Research, Vol.45, No.12 P 1, 6160-6167, 1985.
70. Mitsunobu Sato, Yoshio Hayashi, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura, Masayuki Azuma and Akemichi Ueno :
Intermediate-sized filaments and specific markers in a human salivary gland adenocarcinoma cell line and its nude mouse tumors,
Cancer Research, Vol.45, No.8, 3837-3790, 1985.
71. Yoshio Hayashi, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura, Toshiharu Nitta and Mitsunobu Sato :
Induction of other differentiation stages in neoplastic epithelial duct and myoepithelial cells from the human salivary gland grown in athymic nude mice,
Cancer, Vol.55, No.11, 2575-2583, 1985.
72. Yoshio Hayashi, Mitsunobu Sato and Katsuiku Hirokawa :
Induction of experimental allergic sialadenitis in mice,
The American Journal of Pathology, Vol.118, No.3, 476-483, 1985.
73. 林 良夫, 西田 敏信, 古本 奈奈代, 吉田 秀夫, 梁川 哲雄, 由良 義明, 佐藤 光信 :
頭頸部癌患者の血清β2-microglobulin,
医学のあゆみ, Vol.131, No.7, 451-452, 1984年.
74. Mitsunobu Sato, Hideo Yoshida, Yanagawa Tetsuo, Yura Yoshiaki, Urata Mitsuru, Masayuki Azuma, Furumoto Nanayo, Yoshio Hayashi and Yoshihiro Takegawa :
Interferon Activity and Its Characterization in the Sera of Patients with Head and Neck Cancer,
Cancer, Vol.54, No.1, 1239-1251, 1984.
(Elsevier: Scopus)
75. 橋田 達雄, 細木 秀彦, 藤木 知一, 上村 修三郎, 吉田 秀夫, 佐藤 光信 :
上顎洞根治術後の形態変化および術後性上顎嚢胞のX線学的観察,
歯科放射線, Vol.24, No.2, 114-123, 1984年.
76. Yoshio Hayashi, Toshinobu Nishida, Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura, Nanayo Furumoto and Mitsunobu Sato :
Peripheral Tγ lymphocyte population in head and neck cancer,
Cancer Immunology, Immunotherapy, Vol.17, No.3, 160-164, 1984.
(DOI: 10.1007/BF00205480,   PubMed: 6236876,   Elsevier: Scopus)
77. 西田 敏信, 林 良夫, 吉田 秀夫, 佐藤 光信, 小阪 昌明, 斎藤 史郎 :
唾液分泌型 IgA の酵素免疫測定法とその臨床的意義,
医学のあゆみ, Vol.129, No.11, 767-770, 1984年.
(CiNii: 1520854805426348544)
78. Yoshio Hayashi, Toshinobu Nishida, Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura, Toshiharu Nitta and Mitsunobu Sato :
Peripheral K-lymphocyte population in head and neck cancer,
Cancer, Vol.53, No.11, 2507-2514, 1984.
(DOI: 10.1002/1097-0142(19840601)53:11<2507::aid-cncr2820531124>3.0.co;2-a,   PubMed: 6608986,   Elsevier: Scopus)
79. Mitsunobu Sato, Yoshio Hayashi, Hideo Yoshida, Tetsuo Yanagawa and Yoshiaki Yura :
A family with hereditary lack of T4+ inducer/helper T cell subsets in peripheral blood lymphocytes,
The Journal of Immunology, Vol.132, No.3, 1071-1073, 1984.
80. 林 良夫, 佐藤 光信, 古本 奈奈代, 吉田 秀夫, 梁川 哲雄, 由良 義明, 西田 敏信 :
頭頸部癌患者末梢血リンパ球サブセットの異常, --- 単クローン抗体による解析 ---,
医学のあゆみ, Vol.128, No.8, 507-508, 1984年.
81. Mitsunobu Sato, Hideo Yoshida, Yanagawa Tetsuo, Yura Yoshiaki, Urata Mitsuru, Atsumi Masahiro, Yoshio Hayashi and Yoshihiro Takegawa :
Effects of intradermal administration of streptococcal preparation OK-432 on interferon and natural killer cell activities in patients with oral cancer,
International Journal of Oral Surgery, Vol.13, No.1, 7-15, 1984.
(DOI: 10.1016/s0300-9785(84)80050-2,   PubMed: 6203858,   Elsevier: Scopus)
82. 林 良夫, 西田 敏信, 吉田 秀夫, 梁川 哲雄, 由良 義明, 佐藤 光信 :
頭頸部眼患者からみたTγ細胞の機能,
臨床免疫, Vol.16, No.5, 416-425, 1984年.
83. 林 良夫, 佐藤 光信, 古本 奈奈代, 吉田 秀夫, 西田 敏信, 浜野 修一, 中嶋 克行 :
単クローン抗体によるヒトリンパ球サブセットの加齢および性別変化,
医学のあゆみ, Vol.127, No.1, 25, 1983年.

学術レター:

1. 佐藤 光信, 吉田 秀夫, 由良 義明, 東 雅之, 伊賀 弘起, 加地 亮詞, 板東 高志, 梁川 哲雄, 竹川 佳宏 :
口腔扁平上皮癌に対するUFT,OK-432, 放射線治療を併用した一次治療,
BIOTHERAPY, Vol.6, No.1, 108-111, 1992年.

総説・解説:

1. 佐藤 光信, 林 良夫, 吉田 秀夫, 梁川 哲雄 :
ヒト唾液腺癌細胞の増殖と分化,
臨床科学, Vol.21, No.8, 1065-1072, 1985年.
2. 佐藤 光信, 吉田 秀夫, 林 良夫 :
歯槽歯肉癌,
日本臨牀, Vol.42, 952-958, 1984年.

国際会議:

1. Masato Okamoto, S Furuichi, Yasuhiko Nishioka, T Oshikawa, G Ohe, H Nishikawa, T Tano, U S Armed, Y Moriya, T Matsubara, M Saito, Saburo Sone and Mitsunobu Sato :
Maturation and activation of human dendritic cells in vitro by lipoteichoic acid-related molecule isolated from OK-432, a streptococcal agent: Involvement of Toll-like receptor 4,
American Association for Cancer Research (AAGR), USA, May 2002.

国内講演発表:

1. 岡本 正人, 古市 幸子, 押川 哲也, 大江 剛, 西川 英知, 田野 智之, アハマド シャリフウディン, 葛西 宗江, 永澤 秀子, 宇都 義浩, 堀 均, 佐藤 光信 :
低酸素細胞放射線増感剤Tx-1877誘導体のTh1ケモカイン誘導と抗腫瘍効果,
第7回癌治療増感研究会, 2001年5月.
2. 松木 弘量, 生島 仁史, 西谷 弘, 竹川 佳宏, 長山 勝, 佐藤 光信 :
舌癌の放射線治療成績,
第218回徳島医学会, 1999年1月.
3. 竹川 佳宏, 柏原 賢一, 小池 靖夫, 長山 勝, 佐藤 光信 :
舌扁平上皮癌の治療成績,
第18回日本頭頸部腫瘍学会(札幌), 1994年6月.
4. 竹川 佳宏, 原田 雅史, 長山 勝, 佐藤 光信 :
口腔癌の放射線治療における柴朴湯の臨床的検討,
第43回日本東洋医学会学術総会(横浜) 1992.5, 講演要旨集, 79, 1992年5月.
5. 佐藤 光信, 吉田 秀夫, 加治 亮詞, 岡本 正人, 伊賀 弘起, 川又 均, ワリド アルアデブ, 梁川 哲雄, 竹川 佳宏 :
LAK細胞とγIL-2の動注による免疫療法と放射線療法を併用した上顎洞腺様膿庖癌における骨形成の誘導,
第48回日本癌学会総会(名古屋), 1989年9月.
6. 梁川 哲雄, 坂東 高志, 白神 直行, 吉田 秀夫, 佐藤 光信, 竹川 佳宏 :
ヒト唾液腺癌ヌードマウスモデルにおける実験的放射線化学併用療法,
第13回日本頭頸部腫瘍学会(大阪), 1989年6月.
7. 梁川 哲雄, 坂東 高志, アルアデアブ ワリド, 吉田 秀夫, 竹川 佳宏, 佐藤 光信 :
ヒト唾液腺癌ヌードマウス腫瘍におけるシスプラチンと UFT の併用による抗腫瘍効果,
第47回日本癌学会総会(東京), 1988年9月.
8. 梁川 哲雄, 吉田 秀夫, 由良 義明, 浦田 満, 加地 亮詞, 佐藤 光信, 竹川 佳宏 :
上顎に発生した腺様嚢胞癌に対する放射線治療,5-FU・シスプラチン動注併用療法,
第14回日本口腔外科学会中国・四国地方会(広島), 1985年4月.
9. 林 義典, 城野 良三, 竹川 佳宏, 佐藤 光信, 梁川 哲夫, 林 良夫 :
骨破壊を伴った上顎洞真菌症の一例,
日本医学放射線学会第63回中国・四国地方会(岡山), 1984年11月.
10. 林 良夫, 佐藤 光信, 吉本 奈奈代, 吉田 秀夫, 梁川 哲雄, 由良 義明, 西田 敏信 :
頭頸部癌患者末梢血リンパ球サブセットの異常, --- 単クロ-ン抗体による解析 ---,
医学のあゆみ, Vol.128, No.8, 507-508, 1984年.
11. 梁川 哲雄, 吉田 秀夫, 佐藤 光信, 竹川 佳宏 :
唾液腺造影ーCT法により画像解析を行った耳下腺Warthin腫瘍の1例,
第27回日本口腔外科学会総会(大阪), 1982年10月.
12. Yoshio Hayashi, Toshinobu Nishida, Tetsuo Yanagawa, Hideo Yoshida and Mitsunobu Sato :
Expression of carcinoemryonic antigen in the neoplastic cells originated from human salivary gland,
Tissue Culture in Dentistry, Vol.19, 27-28, 1982.
13. Yoshio Hayashi, Toshinobu Nishida, Toshiharu Nitta, Tetsuo Yanagawa, Hideo Yoshida and Mitsunobu Sato :
Peripheral k lymphocytes as an immunologic parameter in the patients with oral cancer,
Tissure Culture in Dentistry, Vol.19, 25-26, 1982.

その他・研究会:

1. 西岡 安彦, 岡本 正人, 岸 潤, 泉 啓介, 佐藤 光信, 曽根 三郎 :
ブレオマイシン肺線維症におけるToll-like receptorの関与,
ALI研究会, Vol.7, 2003年2月.
2. 加地 亮詞, 由良 義明, 伊賀 弘紀, 吉田 秀夫, 竹川 佳宏, 佐藤 光信 :
口腔扁平上皮癌に対するUFT,OK-432,放射線治療を併用した一次治療,
徳島UFT講演会, 1992年4月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

  • 口腔癌におけるSOCS-1遺伝子制御因子の探索:OK-432,5-FU,放射線 (研究課題/領域番号: 16659556 )
  • OK-432の細菌DNAにおける抗腫瘍活性の探索 (研究課題/領域番号: 15659480 )
  • ヒト唾液腺癌細胞のDNA脱メチル化による分化誘導―骨芽細胞への変換 (研究課題/領域番号: 14771138 )
  • 口腔癌細胞における抗癌剤タキソテールと分化誘導剤ベスナリノン併用の抗癌効果の検索 (研究課題/領域番号: 14657527 )
  • Toll様受容体-4シグナル:口腔癌における抗癌剤・放射線治療の増強効果 (研究課題/領域番号: 14207090 )
  • OK-432由来リポタイコ酸関連分子の細胞受容体の探索 (研究課題/領域番号: 13877343 )
  • LAK,IL-2,放射線との併用によるヒト唾液腺癌細胞の骨芽細胞への分化誘導 (研究課題/領域番号: 12877327 )
  • 口腔癌に対するiNOS遺伝子導入と放射線治療との併用療法の開発 (研究課題/領域番号: 12557176 )
  • 唾液腺癌のベスナリノンによる分化誘導療法に関する基礎的研究 (研究課題/領域番号: 11140250 )
  • 口腔扁平上皮癌細胞におけるnm23遺伝子の分化誘導抑制効果とその制御 (研究課題/領域番号: 10877326 )
  • ベスナリノンを用いた頭頚部癌の分化・アポトーシス誘導療法に関する研究 (研究課題/領域番号: 10307051 )
  • ヒト唾液腺癌細胞におけるEpstein-Barrウイルス持続感染 (研究課題/領域番号: 09877390 )
  • リポタイコ酸:頭頸部癌における放射線、5-フルオロウラシルの治療効果の増強 (研究課題/領域番号: 09557170 )
  • ヒト唾液腺の癌細胞におけるベスナリノンの抗腫瘍活性 (研究課題/領域番号: 08266243 )
  • ヒト唾液腺癌細胞における新規な薬物受容体の検出と分化・アポトーシス誘導機構 (研究課題/領域番号: 06404072 )
  • ヒト唾液腺癌細胞のoxa型ビタミンD誘導体による骨芽細胞への分化誘導に関する研究 (研究課題/領域番号: 06282242 )
  • ヒト唾液腺癌細胞を用いた細胞分化誘導剤のスクリーニングシステムの開発 (研究課題/領域番号: 05557084 )
  • ヒトがん細胞のパラクライン因子とがん増殖の免疫生物学的研究 (研究課題/領域番号: 04151045 )
  • 唾液腺癌の分化誘導療法に関する研究 (研究課題/領域番号: 03454467 )
  • ヒト唾液腺癌細胞における筋上皮或いは腺房細胞に分化誘導する細胞性因子の産生と特性 (研究課題/領域番号: 02152080 )
  • ヒト唾液腺癌細胞における筋上皮或は腺房細胞に分化誘導する細胞性因子の産生と特性 (研究課題/領域番号: 01015070 )
  • 口腔癌のLAK細胞とインタ-ロイキン2による局所免疫療法の開発 (研究課題/領域番号: 63870080 )
  • 口腔癌におけるkillerリンパ球に関与した免疫応答とその治療的意義 (研究課題/領域番号: 61440083 )
  • 研究者番号(00028763)による検索