Tokushima University / Educator and Researcher Directory --- Nagayama, Masaru

Personal Web Page

https://researchmap.jp/read0017466 (researchmap)

Field of Study

○	Oral and Maxillofacial Surgery
○	Cell Biology
○	頭頸部腫瘍

Subject of Study

○	口腔顎顔面領域の再建外科に関する研究 (顎骨再建)
○	ヒト骨組織の石灰化機序の細胞生物学的解析および顎骨再建への応用に関する研究 (ヒト骨組織, 骨形成)
○

Book / Paper

Book:

1.	Masaru Nagayama : 口腔症状を現す血液疾患·出血性素因, Ishiyaku Publishers,Inc., Mar. 2000.
2.	Masaru Nagayama : 口腔出血(歯肉出血), Ishiyaku Publishers,Inc., Jun. 1999.

Academic Paper (Judged Full Paper):

1.	Jun Ishibashi, Kikuji Yamashita, Tatsuo Ishikawa, Hiroyoshi Hosokawa, Kaori Sumida, Masaru Nagayama and Seiichiro Kitamura : The effects inhibiting the proliferation of cancer cells by far-infrared radiation (FIR) are controlled by the basal expression level of heat shock protein(HSP) 70A, Medical Oncology, Vol.25, No.2, 229-237, 2008. (Summary) We developed a tissue culture incubator that can continuously irradiate cells with far-infrared radiation (FIR) of wavelengths between 4 and 20 microm with a peak of 7-12 microm, and found that FIR caused different inhibiting effects to five human cancer cell lines, namely A431 (vulva), HSC3 (tongue), Sa3 (gingiva), A549 (lung), and MCF7 (breast). Then, in order to make clear the control system for the effect of FIR, the gene expression concerned to the inhibition effect by FIR were analyzed. In consequence, basal expression level of HSP70A mRNA was higher in A431 and MCF7 cells than in the FIR-sensitive HSC3, Sa3, and A549 cells. Also, the over expression of HSP70 inhibited FIR-induced growth arrest in HSC3 cells, and an HSP70 siRNA inhibited the proliferation of A431 cells by irradiation with FIR. These results indicate that the effect of a body temperature range of FIR suppressing the proliferation of some cancer cells is controlled by the basal expression level of heat shock protein (HSP) 70A. This finding suggested that FIR should be very effective medical treatment for some cancer cells which have a low level of HSP70. Still more, if the level of HSP70 in any cancer of a patient was measured, the effect of medical treatment by FIR can be foreseen for the cancer. (Keyword) Bromodeoxyuridine / Cell Line, Tumor / Cell Proliferation / HSP70 Heat-Shock Proteins / Humans / infrared rays / Neoplasms / Oligonucleotide Array Sequence Analysis / RNA, Messenger / RNA, Small Interfering (Link to Publication Site) ● Publication site (DOI): 10.1007/s12032-007-9020-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17968683 ● Search Scopus @ Elsevier (PMID): 17968683 ● Search Scopus @ Elsevier (DOI): 10.1007/s12032-007-9020-4 (DOI: 10.1007/s12032-007-9020-4, PubMed: 17968683)
2.	Makoto Fukui, Masami Yoshioka, Kazuhito Satomura, Hiroaki Nakanishi and Masaru Nagayama : Specific-wavelength Visible Light Irradiation Inhibits the Growth of Porphyromonas gingivalis., Journal of Periodontal Research, Vol.43, No.2, 174-178, 2008. (Summary) The effects of laser irradiation on Porphyromonas gingivalis have been reported, but the results are still controversial regarding the efficiency because of the differences of the light sources and irradiation conditions. The aim of this study was to determine the wavelength and irradiation conditions under which the most effective inhibitory effect on P. gingivalis growth was seen without any photosensitizers. Using an Okazaki large spectrograph, monochromatic light spectra ranging from 400 to 700 nm were evaluated to determine which spectra effectively inhibited bacterial growth. Moreover, using a monochromatic 405-nm irradiating device, the effects of various irradiating conditions on P. gingivalis growth were examined. Growth of bacteria irradiated at 400 nm and 410 nm was significantly suppressed compared with a nonirradiated control, whereas wavelengths of 430 nm and longer produced no significant inhibition. A constant energy density of 15 J/cm2 was found to be enough to show an inhibitory effect. Significant inhibition of bacterial growth was found after only 1 min at 50 mW/cm2 irradiation. These results indicate that P. gingivalis growth is specifically suppressed by 405-nm light irradiation, suggesting that visible blue light irradiation is a promising means for eradicating periodontopathogenic bacteria from periodontal lesions. (Keyword) Colony Count, Microbial / Light / Microbial Viability / Porphyromonas gingivalis / Spectrophotometry (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1600-0765.2007.01009.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18302619 ● Search Scopus @ Elsevier (PMID): 18302619 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0765.2007.01009.x (DOI: 10.1111/j.1600-0765.2007.01009.x, PubMed: 18302619)
3.	Masaaki Takechi, Seiko Tatehara, Kazuhito Satomura, Kenji Fujisawa and Masaru Nagayama : Effect of FGF-2 and melatonin on implant bone healing: a histomorphometric study ., Journal of Materials Science. Materials in Medicine, Vol.19, No.8, 2949-2952, 2008. (Summary) Melatonin influences the release of growth hormone and cortisol in humans, and it was recently reported that it promoted bone formation. On the other hand, fibroblast growth factor-2 (FGF-2) was reported to facilitate the proliferation of osteoblasts. In the present study, we examined the effect of recombinant human FGF-2 and melatonin on the promotion of osteogenesis around titanium implants. Twenty-four 10-week-old female rats of the Wistar strain received titanium implants in both tibiae. In the experimental groups, 100 mg/kg body weight of melatonin was administered by intraperitoneal injection for 4 weeks after implantation and 10 microg of FGF-2 was locally injected around the implant sites 5 days after implantation. The control groups were administered saline only. In the control group, few newly formed bone could be seen around the implants. It was observed to be in direct contact with the implant surface, but otherwise unmineralized connective tissue was occasionally interposed. In the experimental group, newly formed bone was observed around the titanium implant. In addition, in contrast to the control group, abundant bone trabeculae were seen in the medullary canal region. Bone trabeculae were directly connected to existing cortical bone. These results strongly suggested that melatonin and FGF-2 have the potential to promote osseointegration. (Keyword) Animals / Bone Development / Female / Fibroblast Growth Factor 2 / Humans / Injections, Intraperitoneal / Melatonin / Prostheses and Implants / Rats / Rats, Wistar / Recombinant Proteins (Link to Publication Site) ● Publication site (DOI): 10.1007/s10856-008-3416-3 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18360797 ● Search Scopus @ Elsevier (PMID): 18360797 ● Search Scopus @ Elsevier (DOI): 10.1007/s10856-008-3416-3 (DOI: 10.1007/s10856-008-3416-3, PubMed: 18360797)
4.	Kazuhito Satomura, Reiko Tokuyama, Tetsuya Yuasa, Y Yamasaki, Seiko Tatehara, Naozumi Ishimaru, Yoshio Hayashi and Masaru Nagayama : Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa., Journal of Oral Pathology & Medicine, Vol.36, No.10, 621-624, 2007. (Summary) We present here the clinical, morphological and immunohistochemical features of a pigmented squamous cell carcinoma (SCC) in the oral mucosa of the hard palate of a 76-year-old Japanese man. He underwent a partial resection of the maxilla subsequent to radiotherapy. The tumor was typical, moderately well-differentiated SCC but had many melanocytes (melanocytosis) within it. Immunohistochemical analysis for stem cell factor (SCF) and endothelin-1, both of which are known to stimulate proliferation and differentiation of melanocytes, revealed prominent expression of both factors in the neoplastic squamous cells of the pigmented SCC, while the non-pigmented oral SCC showed little sign of either factor. These findings strongly suggest that SCF and endothelin-1 secreted by neoplasmic squamous cells are involved in the emergence of a rare variant of oral SCC. (Keyword) Aged / Carcinoma, Squamous Cell / Endothelin-1 / Humans / Male / Melanocytes / Melanosis / Palatal Neoplasms / Stem Cell Factor (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1600-0714.2007.00587.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17944756 ● Search Scopus @ Elsevier (PMID): 17944756 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0714.2007.00587.x (DOI: 10.1111/j.1600-0714.2007.00587.x, PubMed: 17944756)
5.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Hideyuki Takano, Shiho Minamiguchi and Masaru Nagayama : Histological evaluation of apatite cement containing atelocollagen, Dental Materials Journal, Vol.26, No.2, 194-200, 2007. (Summary) Tissue response to apatite cement (AC) containing atelocollagen (AC (ate)) was evaluated using conventional AC (c-AC) as a control material. At one week, the only difference between AC (ate) and c-AC was found in the soft tissue response. With c-AC, a moderate inflammatory response was exhibited: small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were aggregated around the scattered c-AC, whereas AC (ate) showed only a slight inflammatory response with few foreign body giant cells. In terms of bone tissue response, difference between AC (ate) and c-AC was observed at four weeks. New bone formation was observed along the cement at the edge of the pre-existing cortical bone in both c-AC and AC (ate). However, in the case of AC (ate), more abundant and thicker new bone was formed along the cement in the bone marrow when compared with c-AC. (Keyword) Animals / Bone Cements / Bone Regeneration / Bone and Bones / Cattle / Collagen / Foreign-Body Reaction / Hydroxyapatites / Male / Rats / Rats, Wistar / Subcutaneous Tissue / X-Ray Diffraction (Link to Publication Site) ● Publication site (DOI): 10.4012/dmj.26.194 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17621934 ● Search Scopus @ Elsevier (PMID): 17621934 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.26.194 (DOI: 10.4012/dmj.26.194, PubMed: 17621934)
6.	Kazuhito Satomura, Masayuki Kon, Reiko Tokuyama, Tomonari Mayumi, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara and Masaru Nagayama : Osteopetrosis complicated by osteomyelitis of the mandible: a case report including characterization of the osteopetrotic bone, International Journal of Oral and Maxillofacial Surgery, Vol.36, No.1, 86-93, 2007. (Summary) A case of a 53-year-old Japanese man with osteopetrosis complicated by osteomyelitis of the mandible is presented. The patient experienced frequent exacerbations and remissions of osteomyelitis of the mandible, despite undergoing several surgical debridements and sequesterectomies with appropriate antimicrobial therapy, for 3 years. Finally, the patient underwent mandibular segmental resection followed by reconstruction with a titanium reconstruction plate. Fifty-one months after surgery there is no evidence of recurrent osteomyelitis of the mandible, suggesting that a more radical surgical approach is preferable for patients with severe complications resulting from osteopetrosis. Also presented here are the histopathological and biochemical features of the osteopetrotic bone. The osteopetrotic cortical bone was morbidly sclerotic with compact and irregular laminations. Degradation of osteocytes in the osteopetrotic bone was due to hypoxia and lack of nutrition resulting from osteosclerosis. There were no significant differences between osteopetrotic and normal bone according to X-ray diffraction, Fourier transform infrared spectroscopy, collagen content or mineral content. Micro-Vickers hardness measurements showed that osteopetrotic bone was significantly harder than normal bone, and the standard deviation of hardness was greater in osteopetrotic bone. Such a loss of integrity in osteopetrotic bone is considered to be a primary reason for the greater risk of a variety of complications such as pathological fracture and refractory osteomyelitis. (Keyword) Bone Plates / Fatal Outcome / Hardness / Humans / Male / Mandibular Diseases / Mandibular Prosthesis / Microscopy, Electron, Transmission / Middle Aged / Osteocytes / Osteomyelitis / Osteopetrosis / Spectroscopy, Fourier Transform Infrared / X-Ray Diffraction (Link to Publication Site) ● Publication site (DOI): 10.1016/j.ijom.2006.06.009 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17011167 ● Search Scopus @ Elsevier (PMID): 17011167 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijom.2006.06.009 (DOI: 10.1016/j.ijom.2006.06.009, PubMed: 17011167)
7.	Reiko Tokuyama, Kazuhito Satomura, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara, Keiko Kudoh, Hideyuki Takano and Masaru Nagayama : 矯正牽引装置により治療を行った小児外傷性歯牙陥入の1例, Japanese Society of Oral and Maxillofacial Traumatology, Vol.5, No.2, 89-92, 2006.
8.	Reiko Tokuyama, Kazuhito Satomura, Masaaki Takechi, Tetsuya Yuasa, Mayumi Tomonari, Hideyuki Takano and Masaru Nagayama : Intermaxillary Fixation using Alveolar Bone Screws in Mandiblar Fractures, --- Report of Five Cases ---, J. Jpn. Soc. Oral Maxillofac. Trauma, Vol.4, No.1, 10-15, 2006. (Keyword) Alveolar bone screw / Intermaxillary fixation / Mandible fracture
9.	Hiroyoshi Hosokawa, Kikuji Yamashita, Jun Ishibashi, Nanami Ishikawa, Hiroyuki Morimoto, Tomoyasu Ishikawa, Seiichiro Kitamura and Masaru Nagayama : A New Animal Raiser: Effect of Low Temperature Narrow Wavelength Far Infrared Radiation on Tumor Growth of A431 Cells, ITE Letters on Batteries, New Technologies & Medicine, Vol.6, No.6, 597-602, 2005.
10.	Kenji Fujisawa, Youji Miyamoto, Yukihiro Momota, 日比弓紀子 and Masaru Nagayama : Comparison of Resonance Frequency Analyzer and Tooth Mobility Measurement Device for the Evaluation of Dental Implant Stability, Journal of Japanese Society of Oral Implantology, Vol.18, No.3, 406-414, 2005. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205506100608 (CiNii: 1390001205506100608)
11.	Kikuji Yamashita, Hiroyoshi Hosokawa, Ishibashi Jun, Ishikawa Nanami, Hiroyuki Morimoto, Ishikawa Tomoyasu, Masaru Nagayama and Seiichiro Kitamura : Development of CO2 Iincubator with Limited Far-Infrared Radiation for Activation of Mitochondrial Metabolism, ITE Letters on Batteries, New Technologies & Medicine, Vol.6, No.5, 468-472, 2005.
12.	Youji Miyamoto, Kenji Fujisawa, 福田雅幸, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi, Fumiaki Kawano and Daisuke Hinode : 即時荷重インプラントに関する臨床的検討: 臨床術式と1年経過時の臨床成績, Journal of Japanese Society of Oral Implantology, Vol.18, No.2, 292-301, 2005. (Keyword) dental implant / early loading / immediate loading / load (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571135650275179904 (CiNii: 1571135650275179904)
13.	Youji Miyamoto, Kenji Fujisawa, Masayuki Fukuda, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi, Fumiaki Kawano and Daisuke Hinode : Clinical Examination of Immediate Loading Implants, --- Procedure and 1-year Clinical Results ---, Journal of Japanese Society of Oral Implantology, Vol.18, No.2, 78-292-87-301, 2005. (Keyword) dental implant / early louding / immediate loading / load
14.	Tetsuya Yuasa, Youji Miyamoto, Masayuki Kon, Kunio Ishikawa, Masaaki Takechi, Yukihiro Momota, Seiko Tatehara, Hideyuki Takano, Shiro Minamiguchi and Masaru Nagayama : Proliferation and Differentiation of Cultured MC3T3-E1 Osteoblasts on Surface-layer Modified Hydroxyapatite Ceramic with Acid and Heat Treatments, Dental Materials Journal, Vol.24, No.2, 207-212, 2005. (Summary) Effects of functionally gradient calcium phosphate consisting of hydroxyapatite (HAP) and alpha-tricalcium phosphate (alpha-TCP) on proliferation and differentiation of osteoblasts were evaluated using MC3T3-E1 cells. There were no significant differences in the proliferation of MC3T3-E1 cells among HAP-alpha-TCP functionally gradient calcium phosphate, pure HAP, and cell culture plastic wells. mRNA expressions of type I collagen, alkaline phosphate, and osteocalcine were evaluated as indexes of initial; mid-stage, and late-stage osteoblastic differentiation. Basically, HAP-alpha-TCP functionally gradient calcium phosphate and pure HAP enhanced the expressions of the three markers when compared with that of cell culture plastic wells. For type I collagen and alkaline phosphate expressions, HAP-alpha-TCP functionally gradient calcium phosphate showed the same expression level as pure HAP. For osteocalcine expression, HAP-alpha-TCP functionally gradient calcium phosphate showed a higher level than pure HAP. We concluded, therefore, HAP-alpha-TCP functionally gradient calcium phosphate has good potential to be a bone filler material with high osteoconductivity. (Keyword) Osteoblasts / α-tricalcium phosphate / hydroxyapatite (Link to Publication Site) ● Publication site (DOI): 10.4012/dmj.24.207 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16022440 ● Search Scopus @ Elsevier (PMID): 16022440 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.24.207 (DOI: 10.4012/dmj.24.207, PubMed: 16022440)
15.	Tetsuya Yuasa, Masaaki Takechi, Masayuki Taki, Eriko Maeda, Nobuyuki Kamata and Masaru Nagayama : A case of Tooth Extraction of the Patient with Bernard-Soulier Syndrome, Shikoku Dental Research, Vol.17, No.2, 253-256, 2005. (Keyword) Bernard-Soulier症候群 / 抜歯 / 血小板
16.	Nobuyuki Kamata, Ryouichi Fujimoto, Mayumi Tomonari, Masayuki Taki, Masaru Nagayama and Shigeru Yasumoto : Immortalization of human dental papilla, dental pulp, periodontal ligament cells and gingival fibroblasts by telomerase reverse transcriptase, Journal of Oral Pathology & Medicine, Vol.33, No.7, 417-423, 2004. (Summary) Human telomerase reverse transcriptase (hTERT) is catalytic subunit of human telomerase. We studied the immortalization of a series of human dental and periodontal cells by ectopic expression of hTERT and co-expression of hTERT with human papilloma virus 16 (HPV16) or simian virus 40 (SV40). Differentiation abilities of the established cell lines were studied in terms of the mineralized matrix formation and gene expression. We established immortalized gingival fibroblasts by hTERT, dental papilla and periodontal ligament cells by hTERT and HPV16, and pulp cells by hTERT and SV40. The papilla and pulp cells showed mineralization and dentin sialophosphoprotein (DSPP) expression when cultured in the presence of beta-glycerophosphate. The immortalized periodontal ligament cells did not show mineralization or DSPP expression, although expressions of alkaline phosphatase, osteopontin and osteocalcin were detected. These cell lines will be useful tools for studying the repair and regeneration of dental and periodontal tissues and various diseases including odontogenic tumors. (Keyword) Animals / Cell Line, Transformed / Cells, Cultured / Collagen Type I / DNA, Viral / DNA-Binding Proteins / Dental Papilla / Dental Pulp / Extracellular Matrix / Extracellular Matrix Proteins / Fibroblasts / Gene Expression / Gingiva / Humans / Mice / Mice, SCID / Osteocalcin / Osteopontin / Periodontal Ligament / Phosphoproteins / Protein Precursors / Sialoglycoproteins / Telomerase / Transfection (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1600-0714.2004.00228.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15250834 ● Search Scopus @ Elsevier (PMID): 15250834 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0714.2004.00228.x (DOI: 10.1111/j.1600-0714.2004.00228.x, PubMed: 15250834)
17.	Masaaki Takechi, Nobuyuki Kamata, Keiko Kume, Tetsuya Yuasa, Seiko Tatehara and Masaru Nagayama : A case of multiple oral cancer with aplastic anemia, Japanese Journal of Oral & Maxillofacial Surgery, Vol.50, No.7, 438-441, 2004. (Summary) We report a case of multiple oral cancer with aplastic anemia.<BR>The patient was 25-year-old man who was referred to our department for treatment of a mass in the right side of the maxillary gingiva in July 2001. He was given a diagnosis of aplastic anemia at 7 years of age. The maximum amount of mouth opening was 15mm, and a mass with an ulcer was present in the right upper molar region. Computed tomographic examination showed a mass and bone defect in the right maxillary sinus. A biopsy was performed, and the histopathological diagnosis was squamous cell carcinoma. After radiation therapy (external irradiation with <SUP>60</SUP>Co-γ rays), we conducted operation. Red cell and platelet transfusions as well as granulocyte colony-stimulating factor (G-CSF) administration were performed before operation because of decreased numbers of blood cells, and the patient underwent a pertial maxillectomy.<BR>In October 2002, a tumorous lesion appeared in the left side of the mandibular gingiva, and a biopsy revealed squamous cell carcinoma. After the platelet transfusion, resection of the tumor was performed. There has been no evidence of recurrence or metastasis for more than 1 year after surgery. (Keyword) aplastic anemia / multiple oral cancer / squamous cell carcinoma (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.50.438 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206532472704 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.50.438 (DOI: 10.5794/jjoms.50.438, CiNii: 1390001206532472704)
18.	Youji Miyamoto, Kenji Fujisawa, Takashi Sumitomo, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi, Fumiaki Kawano and Daisuke Hinode : Effect of Surface Topography on Ssseointegration Establishment of Dental Implant, --- Comparison between Smooth and Rough Surfaces ---, Journal of Japanese Society of Oral Implantology, Vol.17, No.2, 216-226, 2004. (Keyword) dental implant / early failure / osseointegration / prognosis / surface roughness (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680487133824 (CiNii: 1390282680487133824)
19.	Satoshi Tsutsumi, Nobuyuki Kamata, J Tamara Vokes, Yutaka Maruoka, Koichi Nakakuki, Shoji Enomoto, Ken Omura, Teruo Amagasa, Masaru Nagayama, Fumiko Saito-Ohara, Johji Inazawa, Maki Moritani, Takashi Yamaoka, Hiroshi Inoue and Mitsuo Itakura : The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)., American Journal of Human Genetics, Vol.74, No.6, 1255-1261, 2004. (Summary) Gnathodiaphyseal dysplasia (GDD) is a rare skeletal syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone. By linkage analysis of a large Japanese family with GDD, we previously mapped the GDD locus to chromosome 11p14.3-15.1. In the critical region determined by recombination mapping, we identified a novel gene (GDD1) that encodes a 913-amino-acid protein containing eight putative transmembrane-spanning domains. Two missense mutations (C356R and C356G) of GDD1 were identified in the two families with GDD (the original Japanese family and a new African American family), and both missense mutations occur at the cysteine residue at amino acid 356, which is evolutionarily conserved among human, mouse, zebrafish, fruit fly, and mosquito. Cellular localization to the endoplasmic reticulum suggests a role for GDD1 in the regulation of intracellular calcium homeostasis. (Keyword) Amino Acid Sequence / Animals / CHO Cells / calcium / Camurati-Engelmann Syndrome / Chromosome Mapping / Chromosomes, Human, Pair 11 / Cloning, Molecular / Cricetinae / endoplasmic reticulum / Female / Genes, Dominant / Genetic Linkage / Humans / Jaw Abnormalities / Lod Score / Male / Membrane Proteins / Mice / Molecular Sequence Data / Mutation, Missense / Pedigree / Sequence Homology, Amino Acid / Tissue Distribution / Transfection (Link to Publication Site) ● Publication site (DOI): 10.1086/421527 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15124103 ● Summary page in Scopus @ Elsevier: 2-s2.0-2442653843 (DOI: 10.1086/421527, PubMed: 15124103, Elsevier: Scopus)
20.	Masaaki Takechi, Youji Miyamoto, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama and Kunio Ishikawa : Effects of various sterilization methods on the setting and mechanical properties of apatite cement, Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.69B, No.1, 58-63, 2004. (Summary) Sterilization capability is a necessary requirement for any material that is to be used in a medical application. Therefore, it is necessary for apatite cement (AC) to be sterilized. Because there is little information on the sterilization methods of AC, the aims of this investigation were to evaluate the effects of various sterilization methods, including steam, dry heat, ethylene oxide (EtO) gas, and gamma irradiation sterilizations, on the setting and mechanical properties of AC. In the case of steam sterilization, because AC powder aggregated before setting-time measurements, the setting time could not be measured. When the powder was sterilized by dry heat or EtO gas, the setting time was prolonged significantly and the wet diametral tensile strength (DTS) value decreased significantly. Therefore, sterilizations with steam, dry heat, or EtO gas were suggested to be inappropriate methods for AC. Accordingly, the following experiments focused on gamma sterilization. The setting time of AC was retarded with an increase in gamma irradiation dose. The wet DTS value decreased with the increase in gamma irradiation dose. There was no compositional change due to the gamma irradiation. The following tests were carried out in order to examine the effect of the gamma irradiation on the setting reaction of AC in detail. Tetracalcium phosphate [TTCP: Ca(4)(PO(4))(2)O] and dicalcium phosphate anhydrous (DCPA: CaHPO(4)) were separately irradiated, and the cements were produced with the use of irradiated powder and nonirradiated powder. Although the wet DTS value of AC produced from irradiated TTCP and nonirradiated DCPA decreased with increasing gamma irradiation dose, there was no significant difference. In contrast, the wet DTS value of AC produced from irradiated DCPA and nonirradiated TTCP significantly decreased with the increase in gamma irradiation dose. In conclusion, although the detailed mechanism of the delayed setting time and decreased DTS value was not clarified by the present study, it was found that gamma irradiation affected DCPA more than TTCP. (Keyword) apatite / apatite cement / mechanical properties / gamma / sterilization (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm.b.10031 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15015210 ● Search Scopus @ Elsevier (PMID): 15015210 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.10031 (DOI: 10.1002/jbm.b.10031, PubMed: 15015210)
21.	Yukihiro Momota, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara and Masaru Nagayama : Effects of neutral sodium hydrogen phosphate on the setting property and hemostatic ability of hydroxyapatite putty as a local hemostatic agent for bone, Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.69B, No.1, 99-103, 2004. (Summary) Hydroxyapatite (HAP) putty has been reported to have good hemostatic ability and excellent biocompatibility. Although the setting reaction of HAP putty and resulting transformation to HAP is the reason for this excellent biocompatibility, it also limits the handling period. In this study, the relationship between the setting reaction of HAP putty and its hemostatic ability was investigated, where neutral sodium hydrogen phosphate concentration and post-preparation time were used as indexes. A higher concentration of neutral sodium hydrogen phosphate was found to result in decreased hemostatic ability. The hemostatic ability of HAP putty decreased with time after its preparation; thus it was important to use HAP putty within 10 min after its preparation. The adhesive strength of HAP putty to bone increased with time. Therefore reliable hemostasis can be expected with HAP putty. Although the limited handling time is a drawback, HAP putty is thought to have a good potential as a hemostatic agent-it is highly reliable, and has a high hemostatic ability with excellent biocompatibility. (Keyword) hemostatic agents / hydroxyapatite putty / apatite cement / calcium- phosphate cement / setting reaction (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm.b.20034 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15015217 ● Search Scopus @ Elsevier (PMID): 15015217 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.20034 (DOI: 10.1002/jbm.b.20034, PubMed: 15015217)
22.	Tetsuya Yuasa, Youji Miyamoto, Kunio Ishikiawa, Masaaki Takechi, Yukihiro Momota, Seiko Tatehara and Masaru Nagayama : Effects of apatite cements on proliferation and differentiation of human osteoblasts in vitro, Biomaterials, Vol.25, No.7-8, 1159-1166, 2004. (Summary) Although apatite cement (AC) and sintered hydroxyapatite (s-HAP) are known to show good osteoconductivity, it is not clear whether or not the degree of their osteoconductivity is the same. In addition, it has not been clarified whether or not it is dependent on the type of AC; conventional AC (c-AC), fast-setting AC (fs-AC) or anti-washout AC (aw-AC). The aim of this study was to investigate the effects of ACs on cultured human osteoblasts, as they may provide a useful index of osteoconductivity. Human osteoblasts were cultured on the surfaces of ACs and s-HAP, and were evaluated with respect to cell attachment, proliferation, and differentiation. We found that ACs and s-HAP showed similar cell attachment. No significant difference between ACs and s-HAP was found with respect to the proliferation of osteoblasts. In contrast, we found that the differentiation of osteoblasts was enhanced on the surface of ACs compared with that of s-HAP. However, there was no difference among the types of AC. We therefore concluded that AC may show better osteoconductivity than s-HAP, and that osteoconductivity of AC may be similar, regardless of the type of AC. (Keyword) Biocompatible Materials / Bone Cements / Cell Adhesion / cell differentiation / cell division / Cells, Cultured / Humans / Hydroxyapatites / Materials Testing / Molecular Conformation / Osseointegration / Osteoblasts (Link to Publication Site) ● Publication site (DOI): 10.1016/j.biomaterials.2003.08.003 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14643589 ● CiNii @ National Institute of Informatics (CRID): 1572261551649164288 ● Search Scopus @ Elsevier (PMID): 14643589 ● Search Scopus @ Elsevier (DOI): 10.1016/j.biomaterials.2003.08.003 (DOI: 10.1016/j.biomaterials.2003.08.003, PubMed: 14643589, CiNii: 1572261551649164288)
23.	Masami Ninomiya, Nobuyuki Kamata, Masaru Nagayama and Toshihiko Nagata : エナメル基質タンパクの歯の移植への応用, the Quintessence, Vol.23, No.7, 89-96, 2004.
24.	Yukihiro Momota, Nobuyuki Kamata, Keiko Kume, Seiko Tatehara, Yoshio Hayashi and Masaru Nagayama : Two Cases of So-Called Kuttner Tumor of Submandibular Gland, Shikoku Dental Research, Vol.16, No.2, 419-423, 2004. (Keyword) Kuttner腫瘍 / 唾液腺炎 / 唾液腺腫瘍
25.	Keiko Kudoh, 鎌田伸之, Masaaki Takechi, 山之内浩司, Yoshio Hayashi and Masaru Nagayama : A Case of Quadruple Cancer Arising Synchronously in the Qpper Gingiva,Penis,and Kidney 2 Years After Colon Cancer Treatment, Japanese Journal of Oral & Maxillofacial Surgery, Vol.50, No.8, 503-506, 2004. (Keyword) Quadruple Cancer / Gingiva Cancer (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.50.503 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.50.503 (DOI: 10.5794/jjoms.50.503)
26.	Kenji Fujisawa, Kazuhiro Yokoyama, Youji Miyamoto, Nobuyuki Kamata and Masaru Nagayama : 薬物療法を行った顎関節症患者の臨床的検討, Journal of the Japanese Society for the Temporomandibular Joint, Vol.15, No.3, 260-265, 2003. (Keyword) TMD patients / drug therapy / clinical study (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204420398464 (CiNii: 1390001204420398464)
27.	Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama and Eiji Yamauchi : Effect of the additional installation of implants in the posterior region on the prognosis of treatment in the edentulous mandibular jaw, Clinical Oral Implants Research, Vol.14, No.6, 727-733, 2003. (Summary) The aim of this study was to elucidate the effect of the additional installation of implants in the posterior region on the prognosis of treatment in the edentulous mandibular jaw. Fifteen patients who had received implants (Brånemark system, Nobel Biocare, Gotebörg, Sweden) in the edentulous mandible and completed a 1-year follow-up after the fitting of implant-anchored fixed prostheses were selected. In seven patients (Group A), four or five implants were installed between the mental foramina, and in eight patients (Group P), one or two implants, one on each side, were installed in the posterior regions in addition to the implants between the foramina. All implants of both groups achieved osseointegration. In Group A, there was no implant loss after loading. Six implants were lost in five patients of Group P within 1 year after loading. All of them were located in the posterior region. To elucidate whether or not the failure rate of the implants in the posterior region of Group P after loading was especially high, the failures were also compared with 89 implants, which were installed in the posterior region of the mandibles to support implant-anchored fixed partial prosthesis, during the same period (Group C). The cumulative survival rate of the implants of Group P was 60%, while that of the implants of Group C was 100% (P<0.001). When the survival rates of posterior implants with the same length of the two groups were compared, there were significant differences for the 7- and 10-mm-length implants only. These data demonstrate that the posterior implants in Group P are at greater risk. Deformation of the mandible due to jaw movement was thought to be the most likely cause of the implant loss. Therefore, when such modified treatment is chosen, it should be performed with meticulous attention. (Keyword) fully edentulous mandible / deformation / failure / distortion (Link to Publication Site) ● Publication site (DOI): 10.1046/j.0905-7161.2003.00958.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15015949 ● Search Scopus @ Elsevier (PMID): 15015949 ● Search Scopus @ Elsevier (DOI): 10.1046/j.0905-7161.2003.00958.x (DOI: 10.1046/j.0905-7161.2003.00958.x, PubMed: 15015949)
28.	Eiichiro Kitaoka, Nobuyuki Kamata, 山之内浩司, Kenji Fujisawa, Yoshio Hayashi and Masaru Nagayama : 顎関節に発生した滑膜性軟骨腫症の1例, Japanese Journal of Oral & Maxillofacial Surgery, Vol.49, No.8, 513-516, 2003. (Summary) Although synovial chondromatosis occurs frequently near the ends of long bones, such as the knee, elbow, and hip joints, it rarely affects the temporomandibular joint.<BR>A 52-year-old woman visited our hospital because of swelling in the left side of the temporomandibular joint and trismus. On magnetic resonance imaging, the lesion was found to be chondroid tissue between the left mandibular fossa and the condylar head. Magnetic resonance imaging revealed a high signal mass measuring 35×40mm around the left condylar head. The clinical diagnosis was synovial chondromatosis. Synovectomy and removal of the mass were performed with the patient under general anesthesia. Histopathologically, the mass was formed by typical chondrocytes and was diagnosed to be synovial chondromatosis. The patient has been followed up for 1 year 4 months. There has been no reccurence of the mass or temporomandibular joint disorder. (Keyword) chondromatosis / temporomandibular joint / trismus (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.49.513 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282681508662528 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.49.513 (DOI: 10.5794/jjoms.49.513, CiNii: 1390282681508662528)
29.	Kenji Fujisawa, Youji Miyamoto and Masaru Nagayama : Basic fibroblast growth factor and epidermal growth factor reverse impaired ulcer healing of the rabbit oral mucosa, Journal of Oral Pathology & Medicine, Vol.32, No.6, 358-366, 2003. (Keyword) bFGF / EGF / impaired ulcer healing / oral mucosa / wound healing / FACTOR-BETA / DESALIVATED RATS / TISSUE-REPAIR / WOUNDS / MODEL / EXPRESSION / SALIVA / MICE (Link to Publication Site) ● Publication site (DOI): 10.1034/j.1600-0714.2003.t01-1-00111.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12787043 ● Search Scopus @ Elsevier (PMID): 12787043 ● Search Scopus @ Elsevier (DOI): 10.1034/j.1600-0714.2003.t01-1-00111.x (DOI: 10.1034/j.1600-0714.2003.t01-1-00111.x, PubMed: 12787043)
30.	Masayuki Taki, Nobuyuki Kamata, Kazuhiro Yokoyama, Ryoichi Fujimoto, Satoshi Tsutsumi and Masaru Nagayama : Down-regulation of Wnt-4 and up-regulation of Wnt-5a expression by epithelial-mesenchymal transition in human squamous carcinoma cells, Cancer Science, Vol.94, No.7, 593-597, 2003. (Summary) Gene expression of Wnt-1, 2, 3, 4, 5a, 6 and 7a was analyzed by RT-PCR in eleven squamous cell carcinoma (SCC) cell lines and compared with that in two normal oral keratinocyte strains. There appeared to be an inverse relationship between Wnt-4 and Wnt-5a expressions, i.e., Wnt-4 was not expressed in HOC719-NE, HOC313 or TSU cells, while Wnt-5a was strongly expressed only in these cells. These cell lines showed decreased expression of E-cadherin and elevated expression of vimentin accompanied with strong expressions of Snail and deltaEF1, which have been reported to be transrepressors of E-cadherin and to trigger epithelial-mesenchymal transition (EMT), suggesting associations of Wnt-4 with epithelial phenotype and Wnt-5a with mesenchymal phenotype of SCC cells. To study whether the expressions of these Wnt genes are regulated by EMT, we transfected a Snail-expression vector into A431 and OM-1 cells, which express Wnt-4 but not Wnt-5a. The stably Snail-overexpressing clones showed spindle morphology, increased expression of vimentin and decreased expression of E-cadherin accompanied with augmented expression of deltaEF1. In these clones, down-regulation of Wnt-4 and up-regulation of Wnt-5a were clearly observed. These results indicated that Wnt-4 and Wnt-5a are oppositely affected by EMT, and down-regulation of Wnt-4 and up-regulation of Wnt-5a are possible markers of the malignant phenotype of human SCC. (Keyword) Carcinoma, Squamous Cell / Cell Line / Cell Transformation, Neoplastic / Epithelial Cells / Gene Expression Regulation, Neoplastic / Humans / Keratinocytes / Mesoderm / Polymerase Chain Reaction / Proto-Oncogene Proteins / Tumor Cells, Cultured / Wnt Proteins / Wnt4 Protein (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1349-7006.2003.tb01488.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12841867 ● Search Scopus @ Elsevier (PMID): 12841867 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1349-7006.2003.tb01488.x (DOI: 10.1111/j.1349-7006.2003.tb01488.x, PubMed: 12841867)
31.	Youji Miyamoto, Kenji Fujisawa, Tetsuya Yuasa, Yukihiro Momota, Masaru Nagayama, Eiji Yamauchi, Eiichi Bando and Daisuke Hinode : Evaluation of Risk Factors Concerning Loss of Osseointegration of Dental Implant, Journal of Japanese Society of Oral Implantology, Vol.16, No.2, 278-288, 2003. (Keyword) dental implant / late failure / osseointegration / clinical factor / risk factor (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205509924608 (CiNii: 1390001205509924608)
32.	Youji Miyamoto, Seiko Tatehara, Kenji Fujisawa, Eiichiro Kitaoka, Tetsuya Yuasa, Nobuyuki Kamata, Masaru Nagayama and Eiji Yamauchi : Traumatized Alveolar Bone Defect with Recovery of Oral Functions Using Vertical Alveolar Distraction Osteogenesis and Immediate Loading Implant:A Case Report, J. Jpn. Soc. Oral Maxillofac. Trauma, Vol.22, No.1, 15-21, 2003. (Keyword) Distraction Osteogenesis / Alveolar Ridge Augmentation / Immediate Loading Implant
33.	Kenji Fujisawa, 住友孝史, 舘原誠晃, Youji Miyamoto, Nobuyuki Kamata and Masaru Nagayama : 下顎骨関節突起骨折の臨床的検討, Journal of the Japanese Society for the Temporomandibular Joint, Vol.15, No.1, 18-23, 2003. (Keyword) condylar fracture of the mandible / clinical study / clinical outcome (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679397933440 (CiNii: 1390282679397933440)
34.	Kazuhiro Yokoyama, Nobuyuki Kamata, Ryoichi Fujimoto, Seiji Tsutsumi, Mayumi Tomonari, Masayuki Taki, Hiroyoshi Hosokawa and Masaru Nagayama : Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas., International Journal of Oncology, Vol.22, No.4, 891-898, 2003. (Summary) Loss of E-cadherin expression is a major characteristic of highly invasive and metastatic cancers. Epithelial-mesenchymal transition (EMT) has been advocated to be a causative mechanism for the suppression of E-cadherin and tumor progression. Snail is a zinc finger transcription factor that triggers the EMT and is one of the recently identified E-cadherin repressors. The reverse correlation of Snail and E-cadherin expressions has been reported in many types of human cancers including squamous cell carcinoma (SCC). In this study, we showed that three E-cadherin negative SCC cell lines had a fibroblastic morphology, strong expressions of vimentin, a mesenchymal marker gene, and Snail. Compared to other E-cadherin positive SCC cells, these cells showed higher invasive ability and expression of MMP-2, a matrix degrading enzyme which has been demonstrated to be highly expressed in invasive cancer cells. Over-expression of Snail in A431 cells resulted in the loss of E-cadherin expression, the change of their morphology to fibroblastic, and the up-regulation of vimentin gene expression, indicating that an EMT was induced by Snail. Furthermore, these cells became more invasive and showed higher levels of MMP-2 activity and its gene expression. Luciferase analysis demonstrated that the MMP-2 promoter activity was induced by Snail transfection and the promoter region from -262 to -411 relative to the transcriptional start site was necessary for this induction. These results indicate that Snail is a new inducer of MMP-2 expression and suggest that the EMT contributes to the increased invasion not only through the inhibition of cell-cell adhesion but also the up-regulation of MMP-2 expression in SCC cells. (Keyword) Blotting, Western / Cadherins / Carcinoma, Squamous Cell / Cell Adhesion / Cell Line / Cell Line, Tumor / DNA-Binding Proteins / Disease Progression / Gene Expression Regulation, Neoplastic / Humans / Luciferases / Matrix Metalloproteinase 2 / Neoplasm Invasiveness / Phenotype / Promoter Regions, Genetic / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / Transcription Factors / Transcription, Genetic / Transfection / Up-Regulation / Vimentin / zinc (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12632084 ● Search Scopus @ Elsevier (PMID): 12632084 (PubMed: 12632084)
35.	Seiko Tatehara, Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Masaru Nagayama and Eiji Yamauchi : Use Experience with an Implant-Type Distractor for Vertical Alveolar Distraction Osteogenesis, Journal of Japanese Society of Oral Implantology, Vol.16, No.1, 91-96, 2003. (Keyword) distractor / distraction osteogenesis / alveolar ridge angmentation / osseointegrated implant
36.	SATOSHI TSUTSUMI, NOBUYUKI KAMATA, YUTAKA MARUOKA, MIKI ANDO, OSAMU TEZUKA, SHOJI ENOMOTO, KEN OMURA, Masaru Nagayama, Eiji Kudo, MAKI MORITANI, TAKASHI YAMAOKA and Mitsuo Itakura : Autosomal Dominant Gnathodiaphyseal Dysplasia Maps to Chromosome 11p14.3-15.1, Journal of Bone and Mineral Research, Vol.18, No.3, 413-418, 2003. (Summary) Gnathodiaphyseal dysplasia (GDD) is a syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of jawbones. Although some cases of this syndrome exist in families with autosomal dominant inheritance, the underlying gene has never been identified. We analyzed a large four-generation family with GDD by linkage analysis using genomic DNA from nine affected and six nonaffected family members. A genome-wide search using a set of highly polymorphic microsatellite markers showed evidence for linkage to chromosome 11p14.3-15.1. Two-point linkage analysis of microsatellite markers spanning this locus resulted in a maximum logarithm of odds (LOD) score of 2.70 with a recombination fraction (theta) of 0 at D11S1755, D11S1759, and D11S915, and a maximum LOD score of 3.01 at D11S4114 was obtained in multipoint linkage analysis. Haplotype analysis detected no recombination between GDD and six closely linked markers (D11S928, D11S1755, D11S4114, D11S1759, D11S915, and D11S929) and established the candidate interval of 8.7 cM on chromosome 11p for GDD. Although GDD has been considered to be a variation of osteogenesis imperfecta (MIM 166260), our results indicate that this syndrome is a new and distinct disease entity from other systemic bone diseases. Furthermore, these genetic markers are useful for presymptomatic diagnosis of GDD in some families and for identification of the GDD gene. (Keyword) gnathodiaphyseal dysplasia / autosomal dominant inheritance / linkage analysis / cemento-osseous lesions / osteogenesis imperfecta (Link to Publication Site) ● Publication site (DOI): 10.1359/jbmr.2003.18.3.413 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12619924 ● Search Scopus @ Elsevier (PMID): 12619924 ● Search Scopus @ Elsevier (DOI): 10.1359/jbmr.2003.18.3.413 (DOI: 10.1359/jbmr.2003.18.3.413, PubMed: 12619924)
37.	Satake Hidetaka, Toyoaki Takagi, Shinya Horiuchi, Masahiko Yokozeki, Kenji Fujisawa, Youji Miyamoto, Hiroki Iga, Hideo Yoshida, Masaru Nagayama, Mitsunobu Sato and Keiji Moriyama : Clinical statistical study of jaw deformity patients at the Department of Orthodontics, Tokushima University Dental Hospital, Shikoku Dental Research, Vol.15, No.2, 257-262, 2003.
38.	Kenji Fujisawa, Youji Miyamoto, Nobuyuki Kamata, Masaru Nagayama and Fumihiro Matsumoto : クローズドロックに対するパンピング·マニピュレーション，上関節腔洗浄療法について, Shikoku Dental Research, Vol.15, No.2, 243-250, 2003.
39.	Keiko Kudoh, Kazuhito Satomura, Eiichiro Kitaoka, Reiko Tokuyama and Masaru Nagayama : 骨折治癒過程におけるレプチンの役割, 日本口腔顎顔面外傷学会雑誌, Vol.2, No.2, 61-65, 2003.
40.	Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Yukihiro Momota, Masaru Nagayama, Eiji Yamauchi, Eiichi Bando and Daisuke Hinode : Evaluation of Clinical Factors Conserning Osseointegration Establishment of a Dental Implant, Journal of Japanese Society of Oral Implantology, Vol.15, No.4, 436-445, 2002. (Keyword) dental implant / early failure / osseointegration / clinical factor (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282680486990592 (CiNii: 1390282680486990592)
41.	Nobuyuki Kamata, Eiichiro Kitaoka, 山之内浩司, Yukihiro Momota, Yoshio Hayashi and Masaru Nagayama : 6歳児の下顎骨に発生した若年性(侵襲性)化骨性線維腫の1例, Pediatric Oral and Maxillofacial Surgery, Vol.12, No.2, 25-28, 2002. (Keyword) Juvenile (aggressive) / ossifying fibroma / mandible (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204473373952 (CiNii: 1390001204473373952)
42.	Hiroaki Nakanishi, 住友孝史, Reiko Tokuyama, Kazuhito Satomura, Nobuyuki Kamata, Masaru Nagayama, Yasuhiko Kanagawa, 南満芳 and 橋本隆 : 広範な口腔粘膜病変を初発症状とした腫瘍随伴性天疱瘡の1例, Journal of Japanese Society for Oral Mucous Membrane, Vol.8, No.2, 68-74, 2002. (Keyword) Paraneoplastic pemphigus / Autoimmune bullous disease / B cell-type malignant lymphoma (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001205221838208 (CiNii: 1390001205221838208)
43.	Masaaki Takechi, Youji Miyamoto, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama, Kunio Ishikawa and Kasuomi Suzuki : The in vitro antibiotic release from anti-washout apatite cement using chitosan, Journal of Materials Science. Materials in Medicine, Vol.13, No.10, 973-978, 2002. (Summary) The in vitro antibiotic release from anti-washout apatite cement using chitosan (aw-AC(chi)) was investigated in a preliminary evaluation. Flomoxef sodium was employed as the antibiotic and was incorporated into the powder phase aw-AC(chi) at up to 10%. The setting times were measured for aw-AC(chi) containing various amounts of flomoxef sodium. X-ray diffraction (XRD) analysis was also conducted for the identification of products. To evaluate the drug release profile, set aw-AC was immersed in saline and the released flomoxef sodium was determined at regular intervals. The setting time was prolonged slightly with the addition of flomoxef sodium. The difference at 10% flomoxef sodium (0% vs. 10%) was not significant (p>0.05), and can be negligible in clinic. The XRD analysis revealed that formation of hydroxyapatite (HAP) from aw-AC(chi) was reduced, even after 24 h, when the aw-AC(chi) contained flomoxef sodium at 8% or more. The flomoxef sodium release from aw-AC(chi) showed the typical profile observed in skeleton type drug delivery system (DDS). Changing the concentration of chitosan can control the rate of drug release from aw-AC. Therefore, we conclude that aw-AC(chi) is a good candidate for potential use as a DDS carrier that may be useful in surgical operations. (Link to Publication Site) ● Publication site (DOI): 10.1023/A:1019816830793 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15348192 ● Search Scopus @ Elsevier (PMID): 15348192 ● Search Scopus @ Elsevier (DOI): 10.1023/A:1019816830793 (DOI: 10.1023/A:1019816830793, PubMed: 15348192)
44.	Kenji Fujisawa, 飛梅悟, Nobuyuki Kamata, Masaru Nagayama and 山之内浩司 : 高度な骨性癒着をきたした顎関節強直症の1例, Journal of the Japanese Society for the Temporomandibular Joint, Vol.14, No.2, 222-226, 2002. (Keyword) temporomandibular joint ankylosis / micrognathia / osteoarthrotomy / genioplasty (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001204421599360 (CiNii: 1390001204421599360)
45.	Ryoichi Fujimoto, Nobuyuki Kamata, Kazuhiro Yokoyama, Masayuki Taki, Mayumi Tomonari, Satoshi Tsutsumi, Koji Yamanouchi and Masaru Nagayama : Establishment of Immortalized Human Oral Keratinocytes by Gene Transfer of a Telomerase Component, Journal of Japanese Society for Oral Mucous Membrane, Vol.8, No.1, 1-8, 2002. (Keyword) hTERT / telomerase / normal oral keratinocytes / immortalization (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1571698600014902784 (CiNii: 1571698600014902784)
46.	Masami Ninomiya, Nobuyuki Kamata, Ryoichi Fujimoto, Tomoko Ishimoto, (名) Suryono, Jun-ichi Kido, Masaru Nagayama and Toshihiko Nagata : Application of Enamel Matrix Derivative in Autotransplantation of an Impacted Maxillary Premolar, Journal of Periodontology, Vol.73, No.3, 346-351, 2002. (Summary) The success of tooth transplantation or replantation depends on the viability of periodontal ligament in the planted tooth. Mechanical injury to periodontal tissues frequently results in dental root resorption and dental ankylosis, which leads to the failure of transplantation or replantation. Enamel matrix derivative (EMD) has been recently used to induce periodontal regeneration. In this report, we show a clinical case of EMD application in the transplantation of an inversely impacted and immature tooth. An impacted second premolar was found in the right maxilla of a 16 year-old girl. The tooth was inversely impacted and the dental root was incomplete. When transplantation was carried out, EMD was applied to the periodontal tissues of the extracted premolar. The tooth was fixed at the correct position and the clinical condition was followed for evaluation for 6 months. Radiographs after 3 months exhibited new bone formation surrounding the transplanted tooth. After 6 months, considerable growth of dental root was evident, periodontal ligament-like radiolucency appeared, the vital reaction of the planted tooth was detected, and there were no signs of root resorption or ankylosis. Short-term results from this case indicate that EMD application was effective in the transplantation of an inversely impacted and immature tooth and that EMD might contribute to the growth of dental root and to the prevention of ankylosis. (Keyword) enamel matrix derivative / autotransplantation / periodontal membrane (Link to Publication Site) ● Publication site (DOI): 10.1902/jop.2002.73.3.346 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11922266 ● Search Scopus @ Elsevier (PMID): 11922266 ● Search Scopus @ Elsevier (DOI): 10.1902/jop.2002.73.3.346 (DOI: 10.1902/jop.2002.73.3.346, PubMed: 11922266)
47.	Keiko Kudoh, Kazuhito Satomura, Sachiko Nishisho, Eiichiro Kitaoka, Kouji Yamanouchi, Satoru Tobiume and Masaru Nagayama : Potential role of leptin in endochondral ossification, The Journal of Histochemistry and Cytochemistry, Vol.50, No.2, 159-170, 2002. (Summary) Leptin, a 16-kD circulating hormone secreted mainly by white adipose tissue, is a product of the obese (ob) gene. Leptin acts on human marrow stromal cells to enhance differentiation into osteoblasts and inhibit differentiation into adipocytes. Leptin also inhibits bone formation through a hypothalamic relay. To obtain a better understanding of the potential role of leptin in bone formation, the localization of leptin in endochondral ossification was examined immunohistochemically. High expression of leptin was identified in hypertrophic chondrocytes in the vicinity of capillary blood vessels invading hypertrophic cartilage and in a number of osteoblasts of the primary spongiosa beneath the growth plate. The hypertrophic chondrocytes far from the blood vessels were negative for leptin. Moreover, we detected the production and secretion of leptin by a mouse osteoblast cell line (MC3T3-E1) and a mouse chondrocyte cell line (MCC-5) by RT-PCR, immunocytochemistry, and Western blotting. Leptin enhanced the proliferation, migration, tube formation, and matrix metalloproteinase-2 (MMP-2) activity of human endothelial cells (HUVECs) in vitro. These findings suggest the possibility that leptin exerts its influence on endochondral ossification by regulating angiogenesis. (Keyword) Animals / Animals, Newborn / Blotting, Western / Bone and Bones / Cell Division / Cell Line / Chemotaxis / Chondrocytes / Endothelium, Vascular / Humans / Immunohistochemistry / Leptin / Mice / Mice, Inbred ICR / Neovascularization, Physiologic / Osteogenesis / Reverse Transcriptase Polymerase Chain Reaction / Umbilical Veins (Link to Publication Site) ● Publication site (DOI): 10.1177/002215540205000204 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11799135 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036146459 (DOI: 10.1177/002215540205000204, PubMed: 11799135, Elsevier: Scopus)
48.	Kunio Ishikawa, Youji Miyamoto, Tetsuya Yuasa, Atsuo Ito, Masaru Nagayama and Kazuomi Suzuki : Fabrication of Zn containing apatite cement and its initial evaluation using human osteoblastic cells, Biomaterials, Vol.23, No.2, 423-428, 2002. (Summary) Recently, the effects of Zn2+ on osteogenesis stimulation have become major topics in the research fields of bone formation and organism essential elements. Based on the fundamental finding of Zn2+ with respect to osteogenesis stimulation, Ito et al. have prepared Zn doped beta-tricalcium phosphate (ZnTCP) and have reported that ZnTCP enhances the proliferation of MC3T3-E1 cells. In this investigation, we studied the effects of ZnTCP added to apatite cement (AC) with respect to its setting reaction and proliferation of human osteoblastic cells as an initial evaluation for the feasibility of AC containing ZnTCP. Compositional analysis using powder X-ray diffractometer revealed that ZnTCP shows no reactivity with the setting reaction of AC. As a result, the mechanical strength of set AC decreased increasing amounts of added ZnTCP as if ZnTCP acts as a pore in AC. The setting time of AC was not affected by addition of ZnTCP up to 10%. When AC containing ZnTCP was immersed in alpha-MEM containing 10% bovine serum, Zn2+ was released from AC. Larger amounts of Zn2+ were released from AC containing larger amounts of ZnTCP. When human osteoblastic cells were incubated on the surface of AC discs, proliferation of human osteoblastic cells was significantly increased on the surface of AC that contained 5% ZnTCP when compared with that containing no ZnTCP. In contrast, proliferation of human osteoblastic cells decreased on the surface of AC that contained 10% ZnTCP when compared with that free from ZnTCP; indicating cytotoxicity. We concluded therefore, that addition of ZnTCP to AC is useful to enhance the osteoconductivity of AC when release of Zn2+ can be carefully regulated. (Keyword) ZnTCP / Apatite cement / Osteoblasts / Proliferation (Link to Publication Site) ● Publication site (DOI): 10.1016/S0142-9612(01)00121-1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11761162 ● CiNii @ National Institute of Informatics (CRID): 1571417126705406208 ● Search Scopus @ Elsevier (PMID): 11761162 ● Search Scopus @ Elsevier (DOI): 10.1016/S0142-9612(01)00121-1 (DOI: 10.1016/S0142-9612(01)00121-1, PubMed: 11761162, CiNii: 1571417126705406208)
49.	Hidemi Sasaki, Takashi Yamaoka, Hideyo Ohuchi, Akihiro Yasue, Tsutomu Nohno, Hirotaka Kawano, Shigeaki Kato, Mitsuo Itakura, Masaru Nagayama and Sumihare Noji : Identification of cis-elements regulating expression of Fgf10 during limb development., The International Journal of Developmental Biology, Vol.46, No.7, 963-967, 2002. (Summary) Fibroblast growth factor 10 (FGF10) is known to be expressed in limb mesenchymal cells and to function as a mesenchymal signaling factor involved in epithelial-mesenchymal interactions during limb development. To elucidate regulation of Fgf10 expression, we isolated the promoter region of Fgf10 containing its 2.0 kb upstream 5'-fragment from the initiation codon and its 0.9 kb downstream fragment. Transcriptional activity of the fragment was examined with transgenic mice, using a lacZ-reporter system. Although no significant expression of the reporter gene was observed for the 0.2 kb 5'-fragment, expression was detected in the apical ectodermal ridge of the limb bud and developing cartilage of the limb for the 2.0 kb and 0.7 kb 5'-fragments, respectively. From comparison of the mouse sequences of the 2.0 kb fragment with corresponding sequences of human and chicken Fgf10, we identified 17 conserved putative enhancer motifs for AER expression and other unidentified expressions. For limb cartilage expression, we found putative enhancer sequences conserved among the three species in the 0.7 kb 5'-fragment. In the fragment, three DNA binding motifs were identified in the mouse and human sequence, although they are not conserved in the corresponding chicken sequence. (Keyword) Animals / Base Sequence / Chick Embryo / Conserved Sequence / Extremities / Fibroblast Growth Factor 10 / Fibroblast Growth Factors / Gene Expression Regulation, Developmental / Genes, Reporter / Humans / Mice / Mice, Transgenic / Promoter Regions, Genetic (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12455635 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036433898 (PubMed: 12455635, Elsevier: Scopus)
50.	Nobuyuki Kamata, Masami Ninomiya, Tomoko Azuma, Ryoichi Fujimoto, Mayumi Tomonari, Toshihiko Nagata and Masaru Nagayama : Autotransplantation of Impacted Teeth and Wisdom Teeth, Shikoku Dental Research, Vol.15, No.1, 205-213, 2002. (Keyword) 移植 / 智歯 / 埋伏歯
51.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikiawa, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Kazuomi Suzuki and Masaru Nagayama : Effects of powder phase sterilization on basic properties of apatite cement, Key Engineering Materials, Vol.218-220, 339-342, 2002. (Keyword) Apatite Cement / Hydroxyapatite / γ-Ray Irradiation (Link to Search Site for Scientific Articles) ● Summary page in Scopus @ Elsevier: 2-s2.0-0036166816 (Elsevier: Scopus)
52.	Yukihiro Momota, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama and Kazuomi Suzuki : Evaluation of Feasibility of Hydroxyapatite Putty as a Local Hemostatic Agent for Bone., Journal of Biomedical Materials Research, Vol.63, No.5, 542-547, 2002. (Summary) Although bone wax is known to cause an inflammatory reaction in soft tissue and a delay of bone healing, it is usually the first choice to arrest bleeding from bone. Hydroxyapatite (HAP) putty is proposed here. This study evaluated the feasibility of HAP putty with respect to whether or not it has potential value as a hemostatic agent for bone. First, the adhesive strength of HAP putty to bone was evaluated. The adhesive strength of HAP putty to wet bone was much higher when compared with that of bone wax, even though the adhesive strengths of HAP putty and bone wax to dry bone were equivalent. Next, to evaluate the hemostatic ability of HAP putty, bony defects were made in rabbits. HAP putty could arrest bleeding from bone within 3 min. However, when the hemostasis was performed with bone wax, bleeding was arrested within 8 min. Thus, HAP putty showed better hemostatic ability than bone wax. Finally, the tissue response to HAP putty in rabbit subcutaneous tissue was evaluated. Histological observation revealed a slight inflammatory response around HAP putty, whereas bone wax was surrounded by moderate inflammatory tissue. In conclusion, HAP putty has good potential value to be a hemostatic agent for bone because it has strong adhesion, good hemostatic ability, and biocompatibility. (Keyword) hemostatic agents / hydroxyapatite putty / bone wax / apatite cement, calcium phosphate cement (Link to Publication Site) ● Publication site (DOI): 10.1002/jbm.10332 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12209899 ● Search Scopus @ Elsevier (PMID): 12209899 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.10332 (DOI: 10.1002/jbm.10332, PubMed: 12209899)
53.	Yoshiko Noda, Yukihiro Momota, Kazuhito Satomura, Nobuyuki Kamata, Naozumi Ishimaru and Masaru Nagayama : A case of aspergillosis of the maxillary sinus: discussion of the usefulness of serological examinations, Japanese Journal of Oral & Maxillofacial Surgery, Vol.47, No.12, 811-814, 2001. (Summary) Aspergillosis is caused by infection with <I>Aspergilli</I>. It is often difficult to make an exact diagnosis before identification of <I>Aspergilli</I> by microbial examination because aspergillosis is difficult to differentiate from other diseases. We present a case of aspergillosis of the maxillary sinus that could be diagnosed on serological examination for <I>Aspergilli</I> or fungi specific sugar.<BR>A 51-year-old woman visited to our hospital because of swelling in the gingiva of the maxilla. Radical operation of the maxillary sinus was performed for a clinical diagnosis of aspergillosis of the maxillary sinus. Histopathological examination revealed <I>Aspergilli</I> in the extirpated tissue of the maxillary sinus. Serological examinations showed elevated serum levels of galactomannan and β-D-glucan. Galactomannan is a specific marker for <I>Aspergilli</I>, and β-D-glucan is specific for fungi. Both makers fell to normal levels after operation, Suggesting that serological examinations for galactomannan and β-D-glucan are useful in the diagnosis of aspergillosis of the maxillary sinus. (Keyword) aspergillosis / maxillary sinus / serological examination / galactomannan / β-D-glucan (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.47.811 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206529635968 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.47.811 (DOI: 10.5794/jjoms.47.811, CiNii: 1390001206529635968)
54.	Masaaki Takechi, Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama and Kazuomi Suzuki : Tissue responses to anti-washout apatite cement using chitosan when implanted in the rat tibia, Journal of Materials Science. Materials in Medicine, Vol.12, No.7, 597-602, 2001. (Summary) The tissue response to anti-washout apatite cement using chitosan (aw-AC(chi)) was evaluated by implanting aw-AC(chi) into bone defects of rat tibiae using conventional apatite cement (c-AC) as a control material. During the experimental period up to 16 weeks, the only difference between aw-AC and c-AC was found at two weeks in the tissue response of soft tissue. At two weeks, c-AC showed a moderate inflammatory response; small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were collected around the scattered c-AC, whereas aw-AC showed only a slight inflammatory response and few foreign body giant cells. We found no difference between aw-AC(chi) and c-AC with respect to bone tissue response. Both AC were almost completely surrounded by mature bone at eight weeks. No promotion or reduction of osteoconductivity was observed by chitosan even though it is considered to promote bone formation. We concluded, therefore, that enhancement of bone formation cannot be expected by employing chitosan to obtain anti-washout properties, at least in the concentration used in this study, even though aw-AC(chi) is much more useful than c-AC. (Link to Publication Site) ● Publication site (DOI): 10.1023/A:1011285509391 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15348252 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034928206 (DOI: 10.1023/A:1011285509391, PubMed: 15348252, Elsevier: Scopus)
55.	Kouji Yamanouchi, Kazuhito Satomura, Yuji Gotoh, Eiichiro Kitaoka, Satoru Tobiume, Keiko Kudoh and Masaru Nagayama : Bone formation by transplanted human osteoblasts cultured within collagen sponge with dexamethasone in vitro, Journal of Bone and Mineral Research, Vol.16, No.5, 857-867, 2001.
56.	井上理香, 日浦賢治, Masahiko Yokozeki, 林英司, Masaru Nagayama and Keiji Moriyama : The stability of mesial and distal bony segments after sagittal split ramus osteotomy using PLLA screws, The Japanese Journal of Jaw Deformities, Vol.11, No.1, 29-34, 2001. (Keyword) sagittal split ramus osteotomy / mandibular prognathism / PLLA screws (Link to Publication Site) ● Publication site (DOI): 10.5927/jjjd1991.11.29 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390282679427669248 ● Search Scopus @ Elsevier (DOI): 10.5927/jjjd1991.11.29 (DOI: 10.5927/jjjd1991.11.29, CiNii: 1390282679427669248)
57.	Youji Miyamoto, Taketomo Toh, Kunio Ishikawa, Tetsuya Yuasa, Masaru Nagayama and Kazuomi Suzuki : Effect of added NaHCO₃ on the basic properties of apatite cement, Journal of Biomedical Materials Research, Vol.54, No.3, 311-319, 2001. (Summary) Alternation of a composition of set apatite cement (AC) from carbonate-free apatite (CO3-free AP) to carbonate apatite (CO3-AP) may accelerate replacement of the set AC with bone because CO3-AP can be dissolved much faster than CO3-free AP in the weak acidic solution produced by osteoclasts. In this investigation, NaHCO3 was added to the AC component and the effects of added NaHCO3 on cement-setting behavior and on set mass were studied as an initial step for the fabrication of AC, which can be replaced with bone faster than current AC. When NaHCO3 was added to AC, the resultant set mass contained CO3. Although not all CO3 was incorporated in the set AC, the amount of CO3 incorporated into the set AC increased with the amount of added NaHCO3. Powder X-ray diffraction analysis and Fourier transform infrared spectrometer measurements revealed the formation of B-type CO3-AP. The setting time measured in an incubator at 37 degrees C and 100% relative humidity slowed from 30 to 45 min, indicating that NaHCO3 has an inhibitory effect on AP formation. The diametral tensile strength of the set AC decreased significantly with the addition of NaHCO3. Scanning electron microscopic observation revealed that fine crystals were formed in the set AC when NaHCO3 was added to AC. As a result, the crystallinity indices of the set AC measured using X-ray diffraction and Fourier transform infrared spectroscopy decreased with an increase in the amount of added NaHCO3. The dissolution rate of set AC in weak acid, pH 5.5, increased with the amount of added NaHCO3. We concluded that the formation of B-type CO3-AP and the resulting faster dissolution of set AC in weak acidic solution is preferable for the faster replacement of set AC with bone even though the decreased diametral tensile strength value is a shortcoming. (Keyword) apatite cement / calcium phosphate cement / carbonate apatite / hydroxyapatite / NaHCO₃ (Link to Publication Site) ● Publication site (DOI): 10.1002/1097-4636(20010305)54:3<311::AID-JBM10>3.0.CO;2-H (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11189035 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035809306 (DOI: 10.1002/1097-4636(20010305)54:3<311::AID-JBM10>3.0.CO;2-H, PubMed: 11189035, Elsevier: Scopus)
58.	Tetsuya Yuasa, Youji Miyamoto, Kunio Ishikiawa, Masaaki Takechi, Masaru Nagayama and Kazuomi Suzuki : In vitro resorption of three apatite cements with osteoclasts, Journal of Biomedical Materials Research, Vol.54, No.3, 344-350, 2001. (Summary) To evaluate the replacement of apatite cement (AC) with bone, osteoclasts were incubated for 48 h on the surface of three AC types: conventional AC (c-AC), fast-setting AC (fs-AC), and anti-washout AC (aw-AC), using sintered apatite (AP) and cortical bone as control materials. We found osteoclasts attached to the surface of AC and osteoclastic resorption pits after 48 h of incubation for all experimental AC types. In contrast, no resorption pit was observed on the surface of sintered AP although osteoclasts were attached to the surface of sintered AP. There was no significant difference among the types of AC with respect to the resorption area, but the resorption areas were only approximately 1% of that on the surface of cortical bone. We concluded, therefore, that ACs could be replaced with bone regardless of the type but that it takes extensive time for the ACs to be completely replaced with bone. (Keyword) apatite cement / calcium phosphate cement / hydroxyapatite / osteoclasts / resorption (Link to Publication Site) ● Publication site (DOI): 10.1002/1097-4636(20010305)54:3<344::AID-JBM50>3.0.CO;2-1 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11189039 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035809842 (DOI: 10.1002/1097-4636(20010305)54:3<344::AID-JBM50>3.0.CO;2-1, PubMed: 11189039, Elsevier: Scopus)
59.	Ryoichi Fujimoto, Nobuyuki Kamata, Kazuhiro Yokoyama, Naohiro Ueda, Kazuhito Satomura, Eiji Hayashi and Masaru Nagayama : Expression of telomerase components in oral keratinocytes and squamous cell carcinoma, Oral Oncology, Vol.37, No.2, 132-140, 2001. (Summary) Telomerase activity was measured using a telomeric repeat amplification protocol (TRAP), and expressions of the telomerase components, telomerase associated protein 1 (hTEP1), human telomerase RNA component (hTR), and human telomerase reverse transcriptase (hTERT) were measured by reverse transcriptase-polymerase chain reaction (RT-PCR) in cultured normal oral keratinocytes and oral squamous cell carcinoma (SCC) cells. Telomerase localization was analyzed by in situ hybridization (ISH) in normal, precancerous and cancerous oral tissues. There was a strong correlation of telomerase activity with the expression levels of hTERT but not with hTEP1 or hTR mRNA in the cultured cells. Not only hTEP1 and hTR but also hTERT expression were detected in the basal cells of normal oral mucosa, and the cells expressing these mRNAs were also seen in the upper layer of leukoplakia of gingiva, and a heterogeneous pattern of expression was observed in the oral SCC tissues. These results indicate that there are at least two steps in the increase of telomerase activity during carcinogenesis in oral squamous cells; a change in distribution of cells expressing these telomerase components and the over-expression of hTERT gene in individual cells. (Keyword) Carcinoma, Squamous Cell / Cells, Cultured / Child / Female / Gene Expression Regulation, Neoplastic / Humans / In Situ Hybridization / Keratinocytes / Leukoplakia, Oral / Mouth Mucosa / Mouth Neoplasms / Neoplasm Proteins / Nucleic Acid Amplification Techniques / Reverse Transcriptase Polymerase Chain Reaction / Telomerase (Link to Publication Site) ● Publication site (DOI): 10.1016/S1368-8375(00)00073-7 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11167139 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035122821 (DOI: 10.1016/S1368-8375(00)00073-7, PubMed: 11167139, Elsevier: Scopus)
60.	Kazuhiro Yokoyama, Nobuyuki Kamata, Eiji Hayashi, Tomoaki Hoteiya, Naohiro Ueda, Ryouichi Fujimoto and Masaru Nagayama : Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro, Oral Oncology, Vol.37, No.1, 65-71, 2001. (Summary) The loss of E-cadherin expression has been shown to correlate to the invasion and metastasis of many types of carcinomas. We established E-cadherin positive (HOC719-PE) and negative (HOC719-NE) clones from an oral squamous cell carcinoma (SCC). HOC719-PE cells showed epithelial morphology with E-cadherin expression in the cell membrane, whereas HOC719-NE cells demonstrated fibroblastic morphology without E-cadherin expression. In invasion assay and three dimensional culture, HOC719-NE showed much higher invasive ability than HOC719-PE cells. These cells expressed similar levels of mRNAs for alpha- and beta-catenin. However, HOC719-NE cells, but not HOC719-PE cells, showed strong expression of snail, a transcription factor implicated in the differentiation of epithelial cells into mesenchymal phenotype. This reverse expression of snail and E-cadherin was further observed in other SCC cells including HOC313, and TSU cells that we previously reported to show no expression of E-cadherin protein. These results indicated that the expression of snail has a key role for the acquisition of more invasive and metastatic phenotypes of SCC and the clones we reported here will be useful tools for understanding the mechanism of the transition from epithelial to mesenchymal SCC cells. (Keyword) Cadherins / Carcinoma, Squamous Cell / Cell Division / DNA-Binding Proteins / Gene Expression / Humans / Mouth Neoplasms / Neoplasm Invasiveness / Neoplasm Proteins / RNA, Messenger / RNA, Neoplasm / Reverse Transcriptase Polymerase Chain Reaction / Snail Family Transcription Factors / Transcription Factors / Tumor Cells, Cultured (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11120485 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035215136 (PubMed: 11120485, Elsevier: Scopus)
61.	Eiichiro Kitaoka, Kazuhito Satomura, Eiji Hayashi, Keiko Kudoh, Satoru Tobiume and Masaru Nagayama : Establishment and charcterization of chondrocyte cell lines from the costal cartilage of SV40 large T antigen transgenic mice, Journal of Cellular Biochemistry, Vol.81, No.4, 571-582, 2001. (Summary) Complete understanding of the physiology and pathology of the cartilage is essential to establish treatments for a variety of cartilage disorders and defects such as rheumatoid arthritis, congenital malformations, and tumors of cartilage. Although synthetic materials have been used in many cases, they possess inherent problems including wear of the materials and low mechanical strength. Autograft has been considered very effective to overcome these problems. However, the limitation of the transplant volume is a major problem in autograft to be overcome. The costal cartilage is the most serious candidate for donor site transplantation, since it is the largest permanent hyaline cartilage in the body. To investigate the possibility using the costal cartilage as a transplant source, we have established and characterized three mouse chondrocyte cell lines (MCC-2, MCC-5, and MCC-35) derived from the costal cartilage of 8-week-old male SV40 large T-antigen transgenic mice. At confluence, all the cell lines formed nodules that could be positively stained with alcian blue (pH 2.5). The size of nodules gradually increased during culturing time. After 2 and 6 weeks of culture, RT-PCR analysis demonstrated that all three cell lines expressed mRNA from the cartilage-specific genes for type II collagen, type XI collagen, aggrecan, and link protein. Furthermore, type X collagen expression was detected in MCC-5 and MCC-35 but not in MCC-2. Any phenotypic changes were not observed over 31 cell divisions. Immunocytochemistry showed further that MCC-2, MCC-5, and MCC-35 produced cartilage-specific proteins type II collagen and type XI collagen, while in addition MCC-5 and MCC-35 produced type X collagen. Treatment with 1alpha, 25-dihydroxyvitamin D(3) inhibited cell proliferation and differentiation of the three cell lines in a dose-dependent manner. These phenotypic characteristics have been found consistent with chondrocyte cell lines established from cartilage tissues other than costal cartilage. In conclusion, costal cartilage shows phenotypic similarities to other cartilages, i.e., articular cartilage and embryonic limbs, suggesting that costal cartilage may be very useful as the donor transplantation site for the treatment of cartilage disorders. Furthermore, the cell lines established in this study are also beneficial in basic research of cartilage physiology and pathology. (Keyword) Alkaline Phosphatase / Animals / Antigens, Polyomavirus Transforming / Biological Markers / Calcitriol / Cartilage / Cell Division / Cell Line / Chondrocytes / Collagen / Extracellular Matrix / Gene Expression / Male / Mice / Mice, Transgenic (Link to Publication Site) ● Publication site (DOI): 10.1002/jcb.1075 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11329612 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035016352 (DOI: 10.1002/jcb.1075, PubMed: 11329612, Elsevier: Scopus)
62.	Keiko Kume, Eiji Hayashi, Masaaki Takechi, Kazuhito Satomura, Kenji Fujisawa and Masaru Nagayama : A case of tetanus associated with trismus, Japanese Journal of Oral & Maxillofacial Surgery, Vol.46, No.5, 304-306, 2000.
63.	Satoru Tobiume, Kenji Fujisawa, Hiroaki Nakanishi, Eiji Hayashi, Youji Miyamoto and Masaru Nagayama : A case of first and second branchial arch syndrome in a patient whose profile and occlusion improved in response to orthognatic surgery, Japanese Journal of Oral & Maxillofacial Surgery, Vol.46, No.2, 96-98, 2000. (Summary) We describe a case of first and second branchial arch syndrome in a patient whose profile and occlusion improved in response to orthognatic surgery.<BR>A 2-year-9-month-old boy was referred to our clinic for the treatment of open bite. Because symptoms were mild the patient was placed under observation. However, open bite and bird face became severer as he grew older. Cephalometric analysis indicated mandibular micrognathia. Before operation, we made and analyzed computer tomography-based three-dimensional models. The models were very useful for operation planning. After preoperative orthodontic treatment, sagittal splitting ramus osteotomy and horizontal sliding advancement genioplasty were performed in two stages. (Keyword) first and second branchial arch syndrome / orthognatic surgery (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.46.96 (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1390001206529016704 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.46.96 (DOI: 10.5794/jjoms.46.96, CiNii: 1390001206529016704)
64.	Hiroaki Nakanishi, 林英司, 小積麻衣子, Masaru Nagayama, Fumihiro Matsumoto, 多田羅勝義 and 水谷滋 : 国立療養所徳島病院における筋ジストロフィー患者の口腔内所見, Shikoku Dental Research, Vol.12, 251-257, 2000.
65.	Kenji Fujisawa, Hiroaki Nakanishi, Youji Miyamoto, 宮本悦子, 野田純子, 林英司, Masaru Nagayama, 島川清司, 阿部秀吉 and 森瞬次 : 徳島県立ひのみね整肢医療センター歯科における心身障害児(者)の診療実態について, Shikoku Dental Research, Vol.12, No.2, 269-275, 2000. (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1573950400938250112 (CiNii: 1573950400938250112)
66.	Kouji Nitta, Eiji Hayashi, Kenji Fujisawa, Nobuyuki Kamata, Masaru Nagayama, Naozumi Ishimaru and Yoshio Hayashi : Two cases of ameloblastic fibro-odontoma, Japanese Journal of Oral & Maxillofacial Surgery, Vol.46, No.8, 481-483, 2000. (Link to Publication Site) ● Publication site (DOI): 10.5794/jjoms.46.481 (Link to Search Site for Scientific Articles) ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.46.481 (DOI: 10.5794/jjoms.46.481)
67.	Naohiro Ueda, Nobuyuki Kamata, Eiji Hayashi, Kazuhiro Yokoyama, Toshiaki Hoteiya and Masaru Nagayama : Effects of an anti-angiogenic agent, TNP-470, on the growth of oral squamous cell carcinomas, Oral Oncology, Vol.35, No.6, 554-560, 1999.
68.	Toshiaki Hoteiya, Eiji Hayashi, Kazuhito Satomura, Nobuyuki Kamata and Masaru Nagayama : Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo, Journal of Oral Pathology & Medicine, Vol.28, No.3, 107-111, 1999. (Keyword) cell line / E-cadherin / invasion / oral cancer / SCID mice
69.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Taketomo Toh, Tetsuya Yuasa, Masaru Nagayama and Kazuomi Suzuki : Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing, Journal of Biomedical Materials Research, Vol.48, No.1, 36-42, 1999. (Summary) To evaluate the soft tissue response of calcium phosphate cement (CPC), consisting of an equimolar mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) under conditions close to those encountered in actual surgical procedures, we implanted three types of CPC [conventional CPC (c-CPC), fast-setting CPC (FSCPC), and antiwashout type FSCPC (aw-FSCPC; formerly called nondecay type FSCPC or nd-FSCPC)] subcutaneously in the abdomens of rats immediately (1 min) after mixing. At 1 week after surgery, histological examination and compositional analysis were performed using light microscopy and powder X-ray diffraction (XRD), respectively. The implanted c-CPC was crumbled completely, whereas FSCPC and aw-FSCPC retained their shape. Large vesicles containing copious inflammatory effusion were subcutaneously formed around the c-CPC. Histologically, many foreign-body giant cells were collected around the c-CPC, and moderate inflammatory cell infiltration was observed at 1 week after surgery. In contrast, the FSCPC and aw-FSCPC were covered with a thin layer of granulation tissue that included few giant cells and presented slight inflammatory cell infiltration, and no effusion was observed. The XRD analysis of the c-CPC revealed the presence of some unreacted DCPA even 1 week after implantation, whereas almost no DCPA was found in the FSCPC or aw-FSCPC. In conclusion, it was found that CPC does not always show excellent tissue response. When c-CPC is implanted subcutaneously in rats immediately after mixing, it fails to set and causes a severe inflammatory response. Therefore, the type of CPC should be chosen according to the clinical particulars. CPC should be used in a manner that assures its setting reaction. We recommend the use of FSCPC and aw-FSCPC for surgical applications, such as orthopedics, plastic and reconstructive surgery, and oral and maxillofacial surgery, where the cement might otherwise crumble due to the pressure before setting. (Keyword) Animals / Biocompatible Materials / Bone Cements / Calcium Phosphates / Foreign Bodies / Granuloma / Male / Prostheses and Implants / Rats / Rats, Wistar / skin / Skin Diseases (Link to Publication Site) ● Publication site (DOI): 10.1002/(sici)1097-4636(1999)48:1%3C36::aid-jbm8%3E3.0.co;2-i (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10029148 ● Search Scopus @ Elsevier (PMID): 10029148 ● Search Scopus @ Elsevier (DOI): 10.1002/(sici)1097-4636(1999)48:1%3C36::aid-jbm8%3E3.0.co;2-i (DOI: 10.1002/(sici)1097-4636(1999)48:1%3C36::aid-jbm8%3E3.0.co;2-i, PubMed: 10029148)
70.	Nobuyuki Kamata, Kazuhiro Yokoyama, Ryoichi Fujimoto, Naohiro Ueda, Eiji Hayashi, Hiroaki Nakanishi and Masaru Nagayama : Growth of normal oral keratinocytes and aquamous cell carcinoma cells in a novel protein-free defined medium, In Vitro Cell. Dev. Biol.-Animal, Vol.35, 635-641, 1999.
71.	Kazuhito Satomura, Hiroaki Nakanishi, Kenji Fujisawa, Eiji Hayashi and Masaru Nagayama : Initiation of ectopic epithelial calicification in a calcifying odontogenic cyst, Journal of Oral Pathology & Medicine, Vol.28, 330-335, 1999.
72.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Masaru Nagayama, Masayuki Kon, Kenzo Asaoka and Kazuomi Suzuki : Effects of added antibiotics on the basic properties of anti-washout-type fast-setting calcium phosphate cements, Journal of Biomedical Materials Research, Vol.39, No.2, 308-316, 1998.
73.	Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Kozaburo Nakano, Masaru Nagayama, Atsushi Suzuki, Takashi Ikeda, Eiichi Bando and Daisuke Hinode : Three Cases of Application of Osseointegrated Implant to Surgical Reconstructive Area in Oral Cancer Patients, --- Discussion of the Management of Reconstructive Soft Tissue Surrounding Implants ---, Journal of Japanese Society of Oral Implantology, Vol.11, No.2, 69-77, 1998.
74.	Kenji Fujisawa, 林英司, Nobuyuki Kamata and Masaru Nagayama : ウサギ口腔粘膜における創傷治癒遅延モデルの作製, 日本口腔粘膜学会雑誌, Vol.4, No.1, 54-62, 1998.
75.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Taketomo Toh, Tetsuya Yuasa, Masaru Nagayama and Kazuomi Suzuki : Basic properties of calcium phosphate cement containing atelocollagen in its liquid or powder phases, Biomaterials, Vol.19, 707-715, 1998.
76.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikiawa, Taketomo Toh, Tetsuya Yuasa, Masaru Nagayama and Kazuomi Suzuki : Initial histological evaluation of anti-washout type fast-setting calcium phosphate cement following subcutaneous implantation, Biomaterials, Vol.19, 2057-2063, 1998.
77.	Kunio Ishikiawa, Youji Miyamoto, Masaaki Takechi, Taketomo Toh, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Non-decay type fast-setting calcium phosphate cement: Hydroxyapatite putty containing an increased amount of sodium alginate, Journal of Biomedical Materials Research, Vol.36, No.3, 393-399, 1997.
78.	Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama and Kenzo Asaoka : Blast coating method: New method of coating titanium surface with hydroxyapatite at room temperature, Journal of Biomedical Materials Research, Vol.38, No.2, 129-134, 1997.
79.	Hiroaki Nakanishi, Kouji Yamanouchi, Yuji Gotoh and Masaru Nagayama : The association of platelet-derived growth factor (PDGF) receptor tyrosine phosphorylation to mitogenic response of human osteoblastic cells in vitro, Oral Diseases, Vol.3, 236-242, 1997.
80.	林英司, 布袋屋智朗, Hiroaki Nakanishi, Yukihiro Momota, 中野孝三郎, Kenji Fujisawa and Masaru Nagayama : 同一患者から樹立した3種の口腔癌細胞株とその性状, Japanese Journal of Oral & Maxillofacial Surgery, Vol.43, No.11, 789-796, 1997.
81.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Taketomo Toh, Yuki Yoshida, Masaru Nagayama, Masayuki Kon and Kenzo Asaoka : Tissue response to fast-setting calcium phosphate cement in bone, Journal of Biomedical Materials Research, Vol.37, No.4, 457-464, 1997.
82.	Youji Miyamoto, Kenji Fujisawa, Masaru Nagayama, Norio Haneji and Yoshio Hayashi : Carcinoma in Pleomorphic Adenoma of the Tongue ; Report of a case, Oral Medicine & Pathology, Vol.1, No.2, 111-114, 1996. (Summary) A carcinoma in pleomorphic adenoma occurring in the tongue of a 47-year-old Japanese woman is reported. The present report is the first to describe a carcinoma in pleomorphic adenoma derived from the posterior lingual glands. (Keyword) carcinoma in pleomorphic adenoma / lingual gland / malignant mixed tumor / pleomorphic adenoma / tongue (Link to Search Site for Scientific Articles) ● CiNii @ National Institute of Informatics (CRID): 1570009752234590720 (CiNii: 1570009752234590720)
83.	Youji Miyamoto, Masaru Nagayama and Yoshio Hayashi : Verruciform xanthoma occurring within oral lichen planus, Journal of Oral Pathology & Medicine, Vol.25, No.4, 188-191, 1996.
84.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Non-decay type fast-setting calcium phosphate cement: setting behaviour in calf serum and its tissue response, Biomaterials, Vol.17, 1429-1435, 1996.
85.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Soft tissue response of calcium phosphate cements, Bioceramics, Vol.9, 263-266, 1996.
86.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikiawa, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Basic properties of hydroxyapatite putty made with fast-setting calcium phosphate cement and sodium alginate, Bioceramic, Vol.9, 235-238, 1996.
87.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Masaru Nagayama, Masayuki Kon and Kenzo Asaoka : Non-decay type fast-setting calcium phosphate cement using chitosan, Journal of Materials Science Materials in Medicine, Vol.7, No.6, 317-322, 1996.
88.	Kunio Ishikawa, Youji Miyamoto, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Non-decay type fast-setting calcium phosphate cement, --- : Composite with sodium alginate ---, Biomaterials, Vol.16, No.7, 527-432, 1995.
89.	Koichi Rikimaru, Fumihiro Matsumoto, Eiji Hayashi, Hiroshi Bando and Masaru Nagayama : Evaluation of serum concentration of parathyroid hormone-related protein and its implication in hypercalcemia in squamous cell carcinoma of the head and neck, International Journal of Oral and Maxillofacial Surgery, Vol.24, No.5, 365-368, 1995. (Summary) Hypercalcemia is a common and serious complication associated with squamous cell carcinoma (SCC) and is considered to be caused by a tumor-derived factor, parathyroid hormone-related protein (PTHrP). However, the correlation between serum levels of calcium and PTHrP and the kinetics of PTHrP in SCC of the head and neck is unknown, because the behavior of the circulating form of PTHrP in patients has not been determined. In the present study, the PTHrP concentrations in serum samples from 54 patients (37 with SCC and 17 with benign tumors) were measured by a recently developed radioimmunoassay directed toward the C-terminal region of PTHrP, and the laboratory data including those calcium levels in corresponding samples were reviewed retrospectively. Results showed hypercalcemia in four patients with advanced cancer and in whom elevation of the serum PTHrP concentration was observed simultaneously. The regression analysis also revealed the linear relationship of the calcium level to the PTHrP concentration, but not to the concentration of phosphorus or creatinine, suggesting that monitoring of serum PTHrP level is useful for prediction of hypercalcemia associated with head and neck cancer. (Keyword) Adult / Aged / Aged, 80 and over / Calcium / Carcinoma, Squamous Cell / Creatinine / Female / Forecasting / Head and Neck Neoplasms / Humans / Hypercalcemia / Linear Models / Male / Middle Aged / Neoplasm Proteins / Parathyroid Hormone / Parathyroid Hormone-Related Protein / Phosphorus / Proteins / Regression Analysis / Retrospective Studies / Tumor Markers, Biological (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8627105 ● Search Scopus @ Elsevier (PMID): 8627105 (PubMed: 8627105)
90.	Eiji Hayashi, Koichi Rikimaru and Masaru Nagayama : Simultaneous production of G-and M-CSF by an oral cancer cell line and the synergistic effects on associated leucocytosis, European Journal of Cancer. Part B, Oral Oncology, Vol.31B, No.5, 323-327, 1995. (Summary) We established a novel cell line, TSU, from a oral cancer patient with marked leucocytosis. The culture supernatant of TSU cells promoted granulocytic colony formation by mouse bone marrow cells, indicating that TSU produced granulocyte-colony stimulating factor (G-CSF). The concentration of G-CSF was 2.45 micrograms/mg protein, measured by enzyme-linked immunosorbent assay (ELISA). The maximum number of colonies induced by TSU culture supernatant was more than that achieved with recombinant human G-CSF (rhG-CSF) and the size of the colonies induced by TSU supernatant was obviously larger than those achieved with rhG-CSF. The activity of TSU supernatant was completely inhibited by antihuman G-CSF and macrophage-colony stimulating factor (M-CSF) antibodies, but was only partially inhibited by antihuman G- or M-CSF antibody alone. These results indicate that not only G-CSF but also M-CSF, both of which could be produced by TSU cells, are involved in causing leucocytosis; the results suggest that the synergistic production of G- and M-CSF could play an important role in the leucocytosis associated with oral cancer. (Keyword) Colony-Forming Units Assay / Culture Media, Conditioned / Dose-Response Relationship, Drug / Drug Synergism / Granulocyte Colony-Stimulating Factor / Humans / Leukocytosis / Macrophage Colony-Stimulating Factor / Mouth Neoplasms / Recombinant Proteins / Tumor Cells, Cultured (Link to Publication Site) ● Publication site (DOI): 10.1016/0964-1955(95)00038-0 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8704650 ● Search Scopus @ Elsevier (PMID): 8704650 ● Search Scopus @ Elsevier (DOI): 10.1016/0964-1955(95)00038-0 (DOI: 10.1016/0964-1955(95)00038-0, PubMed: 8704650)
91.	Hiroyuki Inoue, Hitoshi Miki, Kazushi Oshimo, Katuhiro Tanaka, Yasumasa Monden, Akihiro Yamamoto, Susumu Kagawa, Nobuya Sano, Eiji Hayashi, Masaru Nagayama and Yoshio Hayashi : Familial hyperparathyroidism associated with jaw fibroma: case report and literature review, Clinical Endocrinology, Vol.43, No.2, 225-229, 1995. (Summary) A 53-year-old female suffering from renal stones and hypercalcaemia was diagnosed as having primary hyperparathyroidism caused by hyperplasia of the parathyroid glands. She underwent total parathyroidectomy and implantation of parathyroid tissue. After one year, she underwent surgery for a jaw tumour. The pathological findings indicated it to be a cementifying fibroma. Jackson et al. (1990) reported the familial association of hyperparathyroidism with jaw tumours, and they suggested that this condition represents a new clinical syndrome. We believe that our case belongs to this syndrome. (Keyword) Female / Humans / Hyperparathyroidism / Mandibular Neoplasms / Middle Aged / Odontogenic Tumors / Pedigree / Syndrome (Link to Publication Site) ● Publication site (DOI): 10.1111/j.1365-2265.1995.tb01919.x (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7554319 ● Search Scopus @ Elsevier (PMID): 7554319 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1365-2265.1995.tb01919.x (DOI: 10.1111/j.1365-2265.1995.tb01919.x, PubMed: 7554319)
92.	Youji Miyamoto, Kunio Ishikawa, Hirokazu Fukao, Masahiro Sawada, Masaru Nagayama, Masayuki Kon and Kenzo Asaoka : In vivo setting behavior of fast-setting calcium phosphate cement, Biomaterials, Vol.16, No.11, 855-860, 1995. (Summary) The in vivo setting behaviour of fast-setting calcium phosphate cement (FSCPC) between femoral muscles of the rat was investigated to evaluate the possible value of FSCPC for medical and dental application. Conventional CPC (c-CPC) and FSCPC were implanted between femoral muscles, and various aspects of the setting behaviour such as setting time, mechanical strength and conversion ratio of cement into hydroxyapatite (HAP: Ca10(PO4)6(OH)2) were measured by the Vicat needle method, diametral tensile strength (DTS) measurement, and quantitative powder X-ray diffraction (XRD) analysis, respectively. The setting time of FSCPC in vivo was 5-7 min, in contrast to 48 min for c-CPC. As a result of its fast setting, set specimens of FSCPC showed higher mechanical strength from the initial stage than c-CPC. Higher DTS values were observed in FSCPC than c-CPC implanted after 24 h. Powder XRD analysis revealed faster conversion of FSCPC than c-CPC into HAP, which was responsible both for the faster setting and higher mechanical strength from the initial stage. We concluded, therefore, that FSCPC may be used for a wide range of clinical applications, i.e. fields where fast setting is required such as orthopaedic, plastic and reconstructive, and oral and maxillofacial surgery. (Keyword) Animals / Biocompatible Materials / Bone Cements / Calcium Phosphates / Durapatite / Femur / Male / Muscle, Skeletal / Prostheses and Implants / Rats / Rats, Wistar / Tensile Strength / X-ray diffraction (Link to Publication Site) ● Publication site (DOI): 10.1016/0142-9612(95)94147-D (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8527601 ● Search Scopus @ Elsevier (PMID): 8527601 ● Search Scopus @ Elsevier (DOI): 10.1016/0142-9612(95)94147-D (DOI: 10.1016/0142-9612(95)94147-D, PubMed: 8527601)
93.	Eiji Hayashi, Koichi Rikimaru, Kenji Fujisawa, Fumihiro Matsumoto, Yasuhiro Bando and Masaru Nagayama : Diagnosis Significance of Scintigraphy in Head and Neck Cancer, Journal of The Japanese Stomatological Society, Vol.44, No.3, 472-477, 1995.
94.	Koichi Rikimaru, Toshiaki Hoteiya, Kenji Fujisawa, Kozaburo Nakano, Eiji Hayashi and Masaru Nagayama : Effects of Human EGF on Pulmonary Metastasis of Human Squamous Cell Carcinomas in SCID Mice, Journal of The Japanese Stomatological Society, Vol.44, No.2, 151-159, 1995.
95.	Eiji Hayashi, Koichi Rikimaru, Kazuhito Satomura, Kohzaburo Nkano, Toshiaki Hoteiya, Takatoshi Kurasato and Masaru Nagayama : Establiishiment and Characterization of Four Human Oral Cancer Cell Lines, 日本口腔科学学会雑誌, Vol.44, No.1, 47-54, 1995. (Keyword) Oral Cancer Cell Line / Squamous cell carcinoma / Protein free culture / Epidermal growth factor receptor
96.	Yasuhiro Bando, Hiroaki Nakanishi, Yuji Gotoh and Masaru Nagayama : A case of cystic cemento-ossifying fibroma in the mandible, Japanese Journal of Oral & Maxillofacial Surgery, Vol.41, No.2, 163-165, 1995.
97.	Kazuhito Satomura, 力丸浩一, 林英司, 野沢孝行, Youji Miyamoto and Masaru Nagayama : 過去10年間のガマ腫39症例の臨床的検討, Journal of The Japanese Stomatological Society, Vol.44, No.2, 261-264, 1995.
98.	Yuji Gotoh, Kenji Fujisawa, Kazuhito Satomura and Masaru Nagayama : Osteogenesis by human osteoblastic cells in diffusion chamber in vivo, Calcif Tissue Int, Vol.56, 246-251, 1995.
99.	Kazuhito Satomura, 板東泰博, 林英司, Youji Miyamoto and Masaru Nagayama : 維持透析患者に生じた舌癌の1治験例, Japanese Journal of Oral & Maxillofacial Surgery, Vol.40, No.9, 1009-1011, 1994.
100.	Yasuhiro Bando and Masaru Nagayama : Odontogenic cyst induction by periapical infection in rats, Journal of Oral Pathology & Medicine, Vol.22, 323-326, 1993.
101.	Youji Miyamoto, 滝下幸夫, 林英司, Masaru Nagayama, 東富雄, Yoshio Hayashi, 高橋敬治 and 宇山正 : 顎下腺と肺の重複癌の1例, 日本口腔腫瘍学会誌, Vol.4, No.2, 264-269, 1992.
102.	Koichi Rikimaru, Hiromi Masuhara, Hitomi Toda, Shoji Enomoto and Masaru Nagayama : Effects of human EGF on the growth of human squamous cell carcinomas in athymic mice, Japanese Journal of Oral & Maxillofacial Surgery, Vol.38, No.1, 23-29, 1992.
103.	Shinya Kawata, Eiji Hayashi, Youji Miyamoto, Masaru Nagayama, Hiroyo Deguchi, Tomio Azuma and Yoshio Hayashi : Four cases of cementifying fibroma, Japanese Journal of Oral & Maxillofacial Surgery, Vol.38, No.3, 479-485, 1992.
104.	Eiji Hayashi, Akio Hori, Youji Miyamoto, Masaru Nagayama, Hiroyo Deguchi and Yoshio Hayashi : Lung carcinoma suspected to metastarize to the submandibular region by the autopsy, --- Report of a case ---, Japanese Journal of Oral & Maxillofacial Surgery, Vol.38, No.4, 679-680, 1992.
105.	Katsuhiro Yasuda, Kazuhito Satomura and Masaru Nagayama : Behaviour of human ameloblastoma cells in collagen matrix in vitro: an ultrastructural study, Journal of Oral Pathology & Medicine, Vol.20, 438-442, 1991.
106.	Kazuhito Satomura, Kiyotaka Hiraiwa and Masaru Nagayama : Mineralized nodule formation in rat bone marrow stromal cell culture without beta-glycerophosphate, Bone Miner, Vol.14, No.1, 41-54, 1991.
107.	Youji Miyamoto, Masaru Nagayama and Yoshio Hayashi : A Cleft Child With Lobulated Tongue and Lingual Hamartoma: Report of a Case, Journal of Oral and Maxillofacial Surgery, Vol.49, No.6, 644-646, 1991. (Keyword) Cleft Palate / Female / Hamartoma / Humans / Infant / Tongue / Tongue Neoplasms (Link to Publication Site) ● Publication site (DOI): 10.1016/0278-2391(91)90348-P (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 2037922 ● Search Scopus @ Elsevier (PMID): 2037922 ● Search Scopus @ Elsevier (DOI): 10.1016/0278-2391(91)90348-P (DOI: 10.1016/0278-2391(91)90348-P, PubMed: 2037922)
108.	Katsuhiro Yasuda, Kazuhito Satomura, Masaru Nagayama, Yoshio Hayashi and Atsuhito Nakanishi : The behavior of human ameloblastoma tissue in collagen matrix in vitro:an immunohistochemical study, Journal of Oral Pathology & Medicine, Vol.20, No.4, 187-190, 1991. (Keyword) ameloblastoma / collagen matrix / lectin
109.	Youji Miyamoto, Fumihiro Matsumoto, Yukio Takishita, Masaru Nagayama, Hiroyo Deguchi and Yoshio Hayashi : Solitary neurofibroma of the tongue: Report of a case, Japanese Journal of Oral & Maxillofacial Surgery, Vol.37, No.6, 1187-1188, 1991.
110.	Fumihiro Matsumoto, Youji Miyamoto and Masaru Nagayama : Light-and Electron-Microscopic Observations on the Mandibular Condylar Cartilages in Growing Rats on a Low-Calcium Diet, Acta Anatomica, Vol.142, No.1, 41-48, 1991. (Summary) In order to obtain more insight into the physiologic mechanism of endochondral ossification, histological changes occurring in the mandibular condylar cartilage of growing rats fed on a low-calcium diet were investigated by light and electron microscopy. Twenty-three-day-old rats were fed on a normal diet or a low-calcium diet for 8 weeks. For the histological observations the mandibular condyles were dissected from each animal at 1, 2, 4, 5 and 8 weeks after the initiation of the experiment. Histological changes occurring in the mandibular condylar cartilages of the rats fed on a low-calcium diet were as follows: (1) narrow proliferative and mature cell zones and a wide hypertrophic cell zone, (2) inhibition of development of cell organelles in the mature chondrocytes, (3) decrease in dead cells in the proliferative zone, (4) decrease in glycogen accumulation in the chondrocytes and (5) inhibition of calcification in the extracellular matrix of the hypertrophic cell zone. Additionally at the end of the experimental period, the following findings were observed: (1) appearance of small light cells in the mature cell zone and the hypertrophic cell zone and (2) decrease in proteoglycan granules and appearance of large collagen fibrils in the pericellular region of the hypertrophic cell zone. (Keyword) Animals / Bone Development / Calcium, Dietary / Cartilage, Articular / Collagen / Diet / Male / Mandible / Organelles / Rats / Rats, Inbred Strains (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1781238 ● Search Scopus @ Elsevier (PMID): 1781238 (PubMed: 1781238)
111.	Youji Miyamoto, 安田勝裕, 林英司, Kenji Fujisawa, 川田真也, 原友則 and Masaru Nagayama : 当科における5年間の小児入院患者の臨床統計的観察, 小児口腔外科, Vol.1, No.2, 111-117, 1991.
112.	Kenji Fujisawa, Hiroaki Nakanishi, Kazuhito Satomura, 安田勝裕, Youji Miyamoto, Masaru Nagayama, 出口博代 and Yoshio Hayashi : 石灰化歯原性嚢胞の3例, Journal of The Japanese Stomatological Society, Vol.40, No.4, 900-911, 1991.
113.	Kazuhito Satomura and Masaru Nagayama : Ultrasturucture of mineralized nodules formed in rai bone marrow stromal cell culture in vitro, Acta Anatomica, Vol.142, No.2, 97-104, 1991. (Summary) Rat bone marrow stromal cells were cultured in vitro. At days 14-15 of culture, dense clusters of polygonal cells were formed, and they mineralized 2-3 days later. The cells resembling osteoblasts or young osteocytes were histologically observed to be embedded in mineralized or unmineralized extracellular matrices of the nodules. Next, these mineralized nodules were electron-microscopically examined. The osteoblastic cells associated with the nodules had a well-developed rough endoplasmic reticulum, an evident Golgi apparatus and some mitochondria as their intracellular organellae. Some lysosomes and microfilaments were also visible in the cytoplasms. Moreover, some cells protruded cell processes toward the neighboring cells through the extracellular matrix. The extracellular matrix consisted of numerous collagen fibrils which were striated with 60-70 nm axial periodicity and which was similar to bone tissue collagen. A large number of matrix vesicles were scattered among the collagen fibrils in the unmineralized area of the nodules. In contrast, in the mineralized area, numerous matrix vesicles at different stages of maturation and many calcified spherules were observed. That is the mineralization in this culture system was considered to be initiated in association with the matrix vesicles and to progress along the collagen fibrils. From these findings, it was confirmed by the present study that the mineralized nodules formed in this bone marrow stromal cell culture were ultrastructurally similar to bone and that the mineralization also proceeded by going through the normal calcification process. This culture system is considered to be available to study osteogenic differentiation and calcification mechanisms. (Keyword) Alkaline Phosphatase / Animals / Bone Marrow Cells / Bone and Bones / Calcification, Physiologic / Cells, Cultured / Male / Microscopy, Electron / Osteoblasts / Osteocytes / Rats / Rats, Inbred F344 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1781261 ● Search Scopus @ Elsevier (PMID): 1781261 (PubMed: 1781261)
114.	Yukio Takishita, Kiyotaka Hiraiwa and Masaru Nagayama : Effect of retinoic acid on proliferation and differentiation of cultured chondrocytes in terminal differentiation, The Journal of Biochemistry, Vol.107, No.4, 592-596, 1990.
115.	Yuji Gotoh, Kiyotaka Hiraiwa and Masaru Nagayama : In vitro mineralization of osteoblastic cells derived from human bone, Bone and Mineral, Vol.8, No.3, 239-250, 1990. (Summary) Osteoblastic cells were isolated from human maxilla by embedding the bone pieces in collagen gel. The isolated cells could be maintained in monolayer culture up to 50 population doubling levels (PDLs). Both parathyroid hormone (PTH) and prostaglandin E2 (PGE2) increased intracellular cyclic AMP level of the cells. The cells also showed high level of alkaline phosphatase (ALPase) activity and formed mineralized areas in monolayer culture. Electron microscopy demonstrated that these cells were surrounded by numerous well-banded collagen fibrils, among which matrix vesicles were scattered. It was also observed that needle-shaped crystals protruded from some matrix vesicles. These protruded crystals appeared to deposit along the collagen fibrils and a mineralized matrix was formed. The minerals of mineralized matrix mainly consisted of calcium and phosphorus and had the same Ca/P ratio as hydroxyapatite. These results indicate that the cells derived from human bone have characteristics of osteoblastic cells. (Keyword) Alkaline Phosphatase / Bone and Bones / Calcification, Physiologic / Calcium / Cell Division / Cell Separation / Cells, Cultured / Child / Collagen / Cyclic AMP / Dinoprostone / Gels / Humans / Male / Microscopy, Electron / Osteoblasts / Parathyroid Hormone / Phenotype / Phosphorus (Link to Publication Site) ● Publication site (DOI): 10.1016/0169-6009(90)90109-S (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 2157512 ● CiNii @ National Institute of Informatics (CRID): 1360292619080261760 ● Summary page in Scopus @ Elsevier: 2-s2.0-0025178617 (DOI: 10.1016/0169-6009(90)90109-S, PubMed: 2157512, CiNii: 1360292619080261760, Elsevier: Scopus)
116.	安田勝裕, 中西淳仁, Fumihiro Matsumoto and Masaru Nagayama : 顎関節症における心因性要因の検討, 日本顎関節学会雑誌, Vol.2352, No.1, 89-97, 1990. (Keyword) 顎関節症 / 心因性要因 / Y-G / CMI
117.	Yasuda Katsuhiro, Nakanishi Atsuhito, Fumihiro Matsumoto and Masaru Nagayama : TMJ arthrosis related to psychological factors:Report of a case, 日本口腔外科学会雑誌, Vol.35, No.9, 2352-2356, 1989. (Keyword) 顎関節症 / 心因性の要因 / チームアプローチ
118.	Takashi Kita and Masaru Nagayama : Oblique facial clefts: A report of two cases, Journal of The Japanese Stomatological Society, Vol.37, No.1, 271-276, 1988.
119.	Takashi Kita, Kei Satoh, Masaru Nagayama, Tomio Azuma and Akiyo Fujita : A case of gigantic schwannoma of the soft palate and pharynx, Journal of The Japanese Stomatological Society, Vol.37, No.1, 345-350, 1988.
120.	Katsuhiro Yasuda, Kei Satoh, Kiyotaka Hiraiwa, Yukiko Yoshida, Masaru Nagayama and Tomio Azuma : Pycnodysostosis: report of a case, Japanese Journal of Oral & Maxillofacial Surgery, Vol.34, No.8, 1668-1674, 1988.
121.	Youji Miyamoto, Masaru Nagayama and Tomomichi Takagi : マウス(BALB/c)二次口蓋突起癒合に関する研究, Acta Anatomica Nipponica, Vol.62, No.1, 5-18, 1987.
122.	Yasuhiro Bando, Tomio Tukuda, Masaru Nagayama, Yoshiaki Tani and Tomio Azuma : A case of radicular cyst arising from deciduous tooth, Japanese Journal of Oral & Maxillofacial Surgery, Vol.33, No.4, 708-711, 1987.
123.	Miyo Yoshinari, Tomio Tukuda and Masaru Nagayama : 扁平上皮癌の免疫組織化学的研究, Journal of The Japanese Stomatological Society, Vol.36, No.3, 602-612, 1987.
124.	Ichiro Uozato, Kei Satoh, Masaru Nagayama, Akiyo Fujita and Akira Komori : Congenital Epulis: Report of a case, Japanese Journal of Oral & Maxillofacial Surgery, Vol.33, No.8, 1634-1639, 1987.
125.	Miyo Yoshinari and Masaru Nagayama : Epidermoid Cyst of the Uvula: Report of a Case, Journal of Oral and Maxillofacial Surgery, Vol.44, No.10, 828-829, 1986. (Keyword) Epidermal Cyst / Female / Humans / infant / Uvula (Link to Publication Site) ● Publication site (DOI): 10.1016/0278-2391(86)90165-5 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 3463715 ● Summary page in Scopus @ Elsevier: 2-s2.0-0022529370 (DOI: 10.1016/0278-2391(86)90165-5, PubMed: 3463715, Elsevier: Scopus)
126.	Miyo Yoshinari, Yukiko Yoshida, Masaru Nagayama, Yoshiaki Tani and Akira Komori : Clinical observations on 15 cases of dermoid (or epidermoid) cysts in the oral region, Japanese Journal of Oral & Maxillofacial Surgery, Vol.32, No.1, 47-53, 1986.
127.	Takashi Kita, Nozomu Fukuda, Miyo Yoshinari, Jun Satoh and Masaru Nagayama : Median cleft of the upper lip: Report of a case, Japanese Journal of Oral & Maxillofacial Surgery, Vol.31B, No.9, 2144-2149, 1985.

Academic Paper (Unrefereed Paper):

1.	松田定信, 浜野修一, 秋田弘子, 佐藤八重子, Toshinobu Nishida and Masaru Nagayama : 血清中免疫抑制酸性蛋白，シアル酸およびC一反応性蛋白測定試薬の基礎的検討, 徳島県臨床衛生検査技師会誌, Vol.27, No.2, 10-16,
2.	Ryoichi Fujimoto, Nobuyuki Kamata, Masayuki Taki, Mayumi Tomonari, Masaru Nagayama and S Yasumoto : Gene expression of telomerase related proteins in human normal oral and ectocervical epithelial cells, Oral Oncology, Vol.39, No.5, 445-452, 2003. (Summary) We analyzed telomerase activities and gene expressions of telomerase components: hTERT, hTR, hTEP1, telomeric repeat binding factors: TRF1, TRF2, and c-myc, Max and Mad in human normal oral and ectocervical epithelial keratinocytes, comparing with those of squamous carcinoma cells and HPV16- or SV40-immortalized cells. Significant telomerase activity and hTERT expression were detected in primary keratinocytes. However, both were dramatically down-regulated during serial passages. The down-regulation of hTERT mRNA was associated with augmented expression of TRF1. Expression of c-myc was slightly decreased, whereas Mad was expressed in parallel with that of hTERT during passages. We also detected an alternate splicing of hTERT transcript in two of four cancer cells and normal aged epithelial cells. These results suggest that the senescence of normal oral and ectocervical keratinocytes is accompanied with up-regulation of TRF1 and down-regulation of telomerase activity due to transcriptional suppression of active form of hTERT in vitro. (Keyword) Alternative Splicing / Blotting, Southern / Carrier Proteins / Cells, Cultured / DNA-Binding Proteins / Gene Expression Regulation / Humans / Keratinocytes / Mouth / RNA / Reverse Transcriptase Polymerase Chain Reaction / Sequence Analysis / Telomerase / Telomere-Binding Proteins / Telomeric Repeat Binding Protein 1 / Telomeric Repeat Binding Protein 2 (Link to Publication Site) ● Publication site (DOI): 10.1016/S1368-8375(03)00003-4 (Link to Search Site for Scientific Articles) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12747968 ● Search Scopus @ Elsevier (PMID): 12747968 ● Search Scopus @ Elsevier (DOI): 10.1016/S1368-8375(03)00003-4 (DOI: 10.1016/S1368-8375(03)00003-4, PubMed: 12747968)
3.	Masami Ninomiya, Kayoko Akazawa, Kazuhito Satomura, Nobuyuki Kamata, Masaru Nagayama, Keiji Moriyama, Jun-ichi Kido and Toshihiko Nagata : Hypercementosis with the progression of chronic apical periodontitis -A case report, Shikoku Dental Research, Vol.15, No.2, 263-269, 2003.
4.	林英司, Kazuhito Satomura, Kenji Fujisawa, Nobuyuki Kamata and Masaru Nagayama : 口腔顎顔面手術におけるバイポーラシザーズの使用経験, Dental Outlook, Vol.98, No.5, 1141-1144, 2001.
5.	Kazuhito Satomura and Masaru Nagayama : 骨髄間質細胞と組織再生, Shikoku Dental Research, Vol.14, No.1, 219-226, 2001.
6.	Masaru Nagayama : Expression of E-cadherin in oralcancer cell lines and its relationship to invasiveness in SCID mice in vivo, Journal of Oral Pathology & Medicine, Vol.28, 107-111, 1999.
7.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Soft tissue responses of calcium phosphate cements, Bioceramics, Vol.9, 263-266, 1996.
8.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Basic properties of hydroxyapatite putty made with fast-setting calcium phosphate cement and sodium alginate, Bioceramics, Vol.9, 235-238, 1996.
9.	Kunio Ishikawa, Youji Miyamoto, Masaaki Takechi, Taketomo Toh, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Approaches for bone-replacing calcium phosphate cement, --- Effect of NaHCO3 addition on the properties of calcium phosphate cement ---, Bioceramics, Vol.9, 255-258, 1996.

Review, Commentary:

1.	Youji Miyamoto and Masaru Nagayama : 顎・顔面の再建手術について, Shikoku Dental Research, Vol.9, No.2, 99-113, Jan. 1997.

Proceeding of International Conference:

1.	Eiji Hayashi, Kazuhito Satomura, Keiko Kume, Eiichiro Kitaoka and Masaru Nagayama : Effects of emdogain on human dental papilla-derived cells, 78th General Session of the IADR, Washington, D.C., (Summary) 1
2.	Reiko Tokuyama, Kazuhito Satomura, Satoshi Tobiume, Kouji Yamanouchi, Keiko Kume, Eichiro Kitaoka, Sachiko Nishisho, Naoko Masuda, Yukiko Hibi and Masaru Nagayama : Melatonin Promotes the Osteoblastic Differentiation and Bone Formation, The ASBMR 24th Annual Meeting, Texas, (Summary) 1
3.	Reiko Tokuyama, Kazuhito Satomura, Maeda Eriko, Eiichiro Kitaoka, Keiko Kume and Masaru Nagayama : Potential Role of Maspinin Rat Endochondral Ossification, 82th IADR, Hawaii, (Summary) 1
4.	Tetsuya Yuasa, Youji Miyamoto, Yukihiro Momota, Nobuyuki Kamata, Masaru Nagayama, Masayuki Kon and Kunio Ishikawa : Effects of sintered apatite, apatite cement on differentiation of human immortalized dental papilla cells, 3rd Asian BioCeramic Symposium(ABC 2003)in conjunction with Hard-Tissue Nano-Biomaterials Symposium 2003, Fukuoka, (Summary) 1
5.	Seiko Tatehara, Youji Miyamoto, Tetsuya Yuasa, Masaaki Takechi, Masaru Nagayama, Masayuki Kon and Kunio Ishikawa : Mechanism for promotion of the differentiation of human cultured osteoblasts by calciumphosphate ceramics, 3rd Asian BioCeramic Symposium(ABC 2003)in conjunction with Hard-Tissue Nano-Biomaterials Symposium 2003, Fukuoka, (Summary) 1
6.	Youji Miyamoto, Seiko Tatehara, Tetsuya Yuasa, Hiroaki Nakanishi, Kenji Fujisawa and Masaru Nagayama : Measurement of the Zygomatic bone and pilot hole technique for safer installation of zygomatic implant, 16th International Conference on Oral and Maxillofacial Surgery(ICOMS), Athens, (Summary) 1
7.	Seiko Tatehara, Youji Miyamoto, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa and Masaru Nagayama : Effect of locally applied basic firoblast growth factor on distraction osteogenesis in ovadectomized rats, 16th Intemational Conference on Oral and Maxillofacial Surgery(ICOMS), Athens, (Summary) 1
8.	Reiko Tokuyama, Kazuhito Satomura, Maeda Eriko, Eiichiro Kitaoka, Keiko Kume and Masaru Nagayama : Maspin, a Serine Protease Inhibitor, Regulates the Bone Matrix Maturation by Enhancing the Accumulation of Latent TGF-β, 26th ASBMR, Seattle, (Summary) 1
9.	Hiroaki Nakanishi, Kazuhito Satomura, Kenji Fujisawa and Masaru Nagayama : 口腔癌および口腔前痛病変に対する光線力学的療法の応用, 6th Asian Congress on Oral and Maxillofacial Surgery，第49回日本口腔外科学会総会, Chiba, (Summary) 1
10.	Shiho Minamiguchi, Masaaki Takechi, Tetsuya Yuasa, Yukihiro Momota, Seiko Tatehara, Hideyuki Takano, Youji Miyamoto, Kazuhito Satomura and Masaru Nagayama : A basic research on hydroxyapatite-poly(D L-lactide-co glycolic acid)composite scaffolds for bone tissue engineering, The 5th Asian Bio Ceramics Simposium, (Summary) 1
11.	Kazuhito Satomura, Masayuki Kon, Mayumi Tomonari, Masaaki Takechi, Reiko Tokuyama and Masaru Nagayama : Characterization of Osteopetrotic Mandibular cortical bone, Intemational Conference on Oral&Maxillofacial Surgery,
12.	Siho Minamiguchi, Masaaki Takechi, Yukihiro Momota, Youji Miyamoto, Kazuhito Satomura and Masaru Nagayama : A research on the rat subcutaneous tissue of hydroxyapatite-polyD, L-Iactic-co-glycolic acid (PLGA)composite scaffolds for allopatry bone generation., 第1回国際シンポジウム・FDワークショップ「21 世紀の口腔科学が目指すべき方向性」, Awaji, 2007. (Summary) 1
13.	Makoto Fukui, Masami Yoshioka, Kazuhito Satomura, Hiroaki Nakanishi and Masaru Nagayama : Specific Visible Light Irradiation Inhibits the Growth of Porphyromonas gingivalis., 84th General Session & Exhibition of the International Association for Dental Research, Brisbane, Jun. 2006.
14.	Eriko Maeda, Kazuhito Satomura, Reiko Tokuyama, Keiko Kudoh, Yasuhum Yamasaki and Masaru Nagayama : Induced odontogenic differentiation of mouse bone marrow stromal cells., 84th IADR, Jun. 2006.
15.	Reiko Tokuyama, Kazuhito Satomura, Masaaki Taechi, Tetsuya Yuasa, Keiko Kudoh, Seiko Tatehara, Hideyuki Takano, Hiroaki Nakanishi, Eriko Maeda and Masaru Nagayama : Usefulness of self-drilling type alveolar bone screws form mandibular fractures., 84th IADR, Brisbane, 2006.
16.	Yukihiro Momota, Youji Miyamoto, K Ishikawa, Masaaki Takechi, H Takano and Masaru Nagayama : Enhancing Effects on Aggregation of Platelets by Hydroxyapatite Putty as a Topical Hemostatic Agent for Bone, The First International Conference on Mechanics of Biomaterials and Tissues, hawaii, Dec. 2005.
17.	Kenji Fujisawa, Youji Miyamoto, Eiji Yamauchi, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara and Masaru Nagayama : Immediate functional loading of Branemark system implants: One year clinical follow-up study, International Journal of Oral & Maxillofacial Surgery, Vol.34, No.supplement 1, 129, Aug. 2005.
18.	Kazuhito Satomura, Masayuki Kon, M Tomonori, Masaaki Takechi, Reiko Tokuyama and Masaru Nagayama : CHARACTERIZATION OF OSTEOPETROTIC MANDIBULAR CORTICAL BONE, Oral &Maxillofacial Surgery, Vol.34, No.1, 138, Austria, Aug. 2005.
19.	Masaaki Takechi, Yukihiro Momota, Youji Miyamoto, Kazuhito Satomura, Kenji Fujisawa and Masaru Nagayama : Effect of FGF-2 and Melatonin on the promotion of Osseogenesis around Titanium implants., First International Conference on Mechanics of Biomaterials &Tissues, 2005. (Summary) 1
20.	Yukihiro Momota, Youji Miyamoto, Ishikawa Kunio, Masaaki Takechi, Takano Hideyuki and Masaru Nagayama : Enhancing effects aggregation of platelets by hydroxyapatite putty as a topieal hemontatie agent for bone., First International Conference on Mechanics of Biomaterials&Tissues, 2005. (Summary) 1
21.	Seiko Tatehara, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Minamiguchi Siho and Masaru Nagayama : Fabrication and characterization of Porous Alginate/Chitosan/Hydroxyapatite(HAP) composite scaffold, The 5th Asian Bio Ceramics Simposium, Hokkaido, 2005. (Summary) 1
22.	Reiko Tokuyama, Kazuhito Satomura, E Maeda, E Kitaoka, Keiko Kume and Masaru Nagayama : Maspin,a Serine Protease Inhibitor,Regulates the Bone Matrix Maturation by Enhancing the Accumulation of Latent TGF-beta, Journal of Bone and Mineral Research, Vol.19, No.suppl 1, S358, Seattle, Oct. 2004.
23.	Tetsuya Yuasa, Naohiro Oshita, Nobuyuki Kamata, Satoru Eguchi, Seiko Tatehara, Kazuhito Satomura and Masaru Nagayama : 顎裂閉鎖術を行った精神発達遅滞患者の 1例, 6th Asian Congress on Oral and Maxillofacial Surgery，第49回日本口腔外科学会総会, Chiba, Oct. 2004.
24.	Yukihiro Momota, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara and Masaru Nagayama : Effects of neutral sodium hydrogen phosphate on the setting property and hemostatic ability of hydroxyapatite putty as a local hemostatic agent for bone, Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.69B, No.1, 99-103, Apr. 2004. (Summary) Hydroxyapatite (HAP) putty has been reported to have good hemostatic ability and excellent biocompatibility. Although the setting reaction of HAP putty and resulting transformation to HAP is the reason for this excellent biocompatibility, it also limits the handling period. In this study, the relationship between the setting reaction of HAP putty and its hemostatic ability was investigated, where neutral sodium hydrogen phosphate concentration and post-preparation time were used as indexes. A higher concentration of neutral sodium hydrogen phosphate was found to result in decreased hemostatic ability. The hemostatic ability of HAP putty decreased with time after its preparation; thus it was important to use HAP putty within 10 min after its preparation. The adhesive strength of HAP putty to bone increased with time. Therefore reliable hemostasis can be expected with HAP putty. Although the limited handling time is a drawback, HAP putty is thought to have a good potential as a hemostatic agent-it is highly reliable, and has a high hemostatic ability with excellent biocompatibility. (Keyword) hemostatic agents / hydroxyapatite putty / apatite cement / calcium- phosphate cement / setting reaction
25.	Reiko Tokuyama, Kazuhito Satomura, Eriko Maeda, Eiichiro Kitaoka, Keiko Kume and Masaru Nagayama : Potential role of maspin in rat endochondral ossification, Honolulu, Mar. 2004.
26.	Hiroaki Nakanishi, Kazuhiro Yokoyama, Kazuhito Satomura, Nobuyuki Kamata and Masaru Nagayama : Measurement of photoporphyrin IX enhancement in ALA-PDT with a blue-violet clode laser and fibro-optic spectrometer, Miyazaki, May 2003.
27.	Hiroaki Nakanishi, Kazuhito Satomura, Nobuyuki Kamata and Masaru Nagayama : Measurement of protoporphyrin_ IX enhancement in ALA-PDT with a blue-Violet diode laser and fibro-optic spectrometer, 9th World Congress of The International Photodynamic Association, Miyazaki, May 2003.
28.	Youji Miyamoto, Yukihiro Momota, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama and Kunio Ishikiawa : Effects of Neutral Sodium Hydrogen Phosphate on Setting Property and Hemostatic Ability of Hydroxyapatite Putty as a Local Hemostatic Agent for Bone, 15th International Symposium on Ceramics in Medicine, Vol.240-242, 373-376, Sydney, Dec. 2002. (Keyword) hydroxyapatite putty / haemostatic agent / bone wax / bome cement
29.	Sachiko Nishisho, Kazuhito Satomura, Eiichiro Kitaoka, Reiko Tokuyama, Keiko Kume and Masaru Nagayama : An activating Gs-alpha mutation is a common cause of monoostotic fibrous dysplasia and ossifying fibroma of the mandible, San Diego, Mar. 2002.
30.	Yukihiro Momota, Youji Miyamoto, K Ishikawa, Masaaki Takechi, Tetsuya Yuasa, T Toh, Masaru Nagayama and K Suzuki : Evalution of Hydroxyapatite-Putty as a Hemostatic Agent, Proceeding of the 13th Int.Symp.on Ceramics in Medicine, Vol.22-26, 849-852, Bologna, Nov. 2000. (Keyword) Apatite Cement / Bone Wax / Calcium Phosphate Cement / Hemostatic Agents
31.	Keiko Kume, Kazuhito Satomura, Kouji yamanouchi, Eiichiro Kitaoka, Satoru Tobiume, Sachiko Nishisho, Naoko Masuda and Masaru Nagayama : Localization of leptin in endochondral ossification of mouse femur, Toronto, Sep. 2000.
32.	Keiko Kume, Kazuhito Satomura, Satoru Tobiume, Eiichiro Kitaoka, Kouji Yamanouchi, Eiji Hayashi and Masaru Nagayama : Emdogain promotes the differentiation of human bone marrow cells, Washington, D.C., Apr. 2000.
33.	Eiichiro Kitaoka, Kazuhito Satomura, Keiko Kume, Satoru Tobiume, Kouji Yamanouchi, Eiji Hayashi and Masaru Nagayama : Establishment of chondrocyte cell lines from SV40 transgenic mice, Washington, D.C., Apr. 2000.
34.	Kazuhito Satomura, Eiji Hayashi, Keiko Kume, Kouji Yamanouchi, Eiichiro Kitaoka, Satoru Tobiume and Masaru Nagayama : Effects of Emdogain on human dental papilla-derived cells, Washington, D.C., Apr. 2000.
35.	Eiichiro Kitaoka, Kazuhito Satomura, Eiji Hayashi, Kouji Yamanouchi, Satoru Tobiume, Keiko Kume and Masaru Nagayama : Establishment and characterization of three chondrocyte cell lines derived from costal cartilage of SV40 large T antigen transgenic mice, St. Louis, MO, USA, Oct. 1999.
36.	Kazuhito Satomura, Eiji Hayashi and Masaru Nagayama : Immunohistochemical localization of non-collagenous priteins in human tooth germ, Vancouver, Canada, Mar. 1999.
37.	Eiji Hayashi, Kazuhito Satomura and Masaru Nagayama : Three-dimensional in vitro culture of human dental papilla-derived cells, Vancouver, Canada, Mar. 1999.
38.	Kouji Yamanouchi, Kazuhito Satomura, Yuji Gotoh, Eiichiro Kitaoka, Keiko Kume and Masaru Nagayama : In vivo bone formation by human osteoblastic cells culture with collagen sponge in vitro, San Francisco, Dec. 1998.
39.	Eiji Hayashi, Kazuhito Satomura, Eiichiro Kitaoka, Toshiaki Hoteiya and Masaru Nagayama : Receptor tyrosine kinase expression in human dental papilla-derived cells, Nice, France, Jun. 1998.
40.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Kenzo Asaoka and Masaru Nagayama : Effects of antibiotics addition on the basic properties of nd-FSCPC, Journal of Dental Research, Vol.76, No.Spec, 242, Orlando, Mar. 1997.
41.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon, Kenzo Asaoka and Masaru Nagayama : Basic properties of calcium phosphate cement containing collagen, Journal of Dental Research, Vol.76, No.Spec, 243, Orlando, Mar. 1997.
42.	Kunio Ishikawa, Youji Miyamoto, Masaaki Takechi, Masayuki Kon, Kenzo Asaoka and Masaru Nagayama : Basic properties and tissue response of hydroxyapatite putty, Journal of Dental Research, Vol.76, No.Spec, 150, Orlando, Mar. 1997.
43.	Eiji Hayashi, Kazuhito Satomura, Toshiaki Hoteiya, Kikuji Yamashita and Masaru Nagayama : Isolation and characterization of human dental papilla-derived cells, Orlando, FL, USA, Mar. 1997.
44.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon and Masaru Nagayama : Soft tissue responses of calcium phosphate cements, Proceedings of the 9th International Symposium on Ceramics in Medicine, 263-266, Otsu, Nov. 1996.
45.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Masayuki Kon and Masaru Nagayama : Basic properties of hydroxyapatite putty made with fast-setting calcium phosphate cement and sodium alginate, Proceedings of the 9th International Symposium on Ceramics in Medicine, 235-238, Otsu, Nov. 1996.
46.	Kunio Ishikawa, Youji Miyamoto, Masaaki Takechi, Taketomo Toh, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Approaches for bone-replacing calcium phosphate cement, --- Effect of NaHCO3 addition on the properties of calcium phosphate cement ---, Proceedings of the 9th International Symposium on Ceramics in Medicine, 255-258, Otsu, Nov. 1996.
47.	E Hayashi, Takao Hanawa, Kikuji Yamashita, Masaru Nagayama, Kenzo Asaoka, Seiichiro Kitamura, Hidemi Ukai and Kouichi Murakami : Observation of osteogenic cells on calcium-ion-mixing titanium using TEM, Journal of Dental Research, Vol.75, No.Spec, 396, San Francisco, Mar. 1996.
48.	Kikuji Yamashita, Takao Hanawa, E Hayashi, Seiichiro Kitamura, Kenzo Asaoka, Masaru Nagayama, Hidemi Ukai and Kouichi Murakami : Calcification formed by osteogenic cells cultured on calcium-ion-mixing titanium, Journal of Dental Research, Vol.75, No.Spec, 309, San Francisco, Mar. 1996.
49.	H Fukao, Youji Miyamoto, M Sawada, Masaru Nagayama, Masayuki Kon, Kunio Ishikawa and Kenzo Asaoka : In vivo reactions of functionally gradient ceramic calcium phosphate, 3rd World Congress for Oral Implantology, Yokohama, Apr. 1994.

Proceeding of Domestic Conference:

1.	Eiichiro Kitaoka, Nobuyuki Kamata, 山之内浩司, Yukihiro Momota, Yoshio Hayashi and Masaru Nagayama : 6歳児の下顎骨に発生した若年性(侵襲性)化骨性線維種の1例, 第14回日本小児口腔外科学会, (Summary) 1
2.	高井三和, Youji Miyamoto, Kenji Fujisawa, 住友孝史, 瀧雅行 and Masaru Nagayama : 右側上顎第二乳臼歯が萌出後に歯槽骨内に埋入した1例, 第50回日本口腔科学会中国四国地方部会, (Summary) 1
3.	Youji Miyamoto, Kenji Fujisawa, Seiko Tatehara, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi and Daisuke Hinode : ブローネマルクインプラントを使用した即時荷重インプラントの経験, 第47回日本口腔外科学会, (Summary) 1
4.	Hiroaki Nakanishi, 住友孝史, Kazuhiro Yokoyama, Kenji Fujisawa, Youji Miyamoto, Nobuyuki Kamata and Masaru Nagayama : 下顎骨骨折線上の歯に関する臨床統計学的検討, 第2回日本外傷歯学会, (Summary) 1
5.	増田尚子, Kazuhito Satomura, 林英司, Kikuji Yamashita, Eiichiro Kitaoka, Seiichiro Kitamura and Masaru Nagayama : 培養ヒト歯乳頭細胞の象牙質・歯髄組織形成能, 第47回日本口腔外科学会,
6.	Kenji Fujisawa, Youji Miyamoto, Tetsuya Yuasa, Yukihiro Momota, Masaaki Takechi, Seiko Tatehara, Masaru Nagayama and Eiji Yamauchi : 頬骨インプラント埋入のための頬骨の計測およびpilot hole techniqueの考案, 第32回日本口腔インプラント学会, (Summary) 1
7.	Keiko Kume, Kazuhito Satomura, Eiichiro Kitaoka, 飛梅悟, 西庄佐智子, 増田尚子, Reiko Tokuyama, 日比弓紀子 and Masaru Nagayama : 骨折治癒過程におけるレプチンの役割―抗肥満ホルモンレプチンの新たな可能性, 第4回日本口腔顎顔面外傷学会総会, (Summary) 1
8.	Kenji Fujisawa, 飛梅悟, Youji Miyamoto, Nobuyuki Kamata and Masaru Nagayama : 関節突起骨折患者の臨床統計的観察, 第15回日本顎関節学会総会, (Summary) 1
9.	Seiko Tatehara, Youji Miyamoto, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa and Masaru Nagayama : 骨粗鬆症ラットの仮骨延長に関する実験的研究, 第56回日本口腔科学会総会, (Summary) 1
10.	Eiichiro Kitaoka, Nobuyuki Kamata, Kazuhiro Yokoyama, 藤本良一, 瀧雅行 and Masaru Nagayama : 細胞生物学的検討を行った舌軟骨腫の1例, 第56回日本口腔科学会総会, (Summary) 1
11.	藤本良一, Nobuyuki Kamata, 堤聡, 友成真弓, 瀧雅行, Kazuhiro Yokoyama, Masaru Nagayama and 安本茂 : テロメラーゼ導入によるヒト正常歯乳頭，歯髄，歯根膜および歯肉線維芽細胞の不死化, 第56回日本口腔科学会総会,
12.	前田恵利子, Kenji Fujisawa, Hiroaki Nakanishi, Yukihiro Momota, 日比弓紀子, Youji Miyamoto and Masaru Nagayama : 片側性下唇痩に口蓋垂裂を合供したvan der Woude症候群の1例, 第51回日本口腔科学会中国四国地方部会, (Summary) 1
13.	Eiichiro Kitaoka, Hiroaki Nakanishi, Youji Miyamoto, Nobuyuki Kamata, Yoshio Hayashi and Masaru Nagayama : 長期にわたり経過覿察を行っている先天性舌リンパ管腫の1例, 第15回日本小児口腔外学会,
14.	住友孝史, Youji Miyamoto, Kenji Fujisawa, Tetsuya Yuasa, Masaru Nagayama, Eiji Yamauchi, Fumiaki Kawano and Daisuke Hinode : インプラントの表面形状がオッセオインテグレーション獲得に及ぼす影響一滑面と粗面インプラントの比較-, 第33回日本口腔インプラント学会総会, (Summary) 1
15.	日比弓紀子, Youji Miyamoto, Kenji Fujisawa, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, 住友孝史 and Masaru Nagayama : インプラント安定性評価における共鳴振動周波数分析装置(Osstell)の信頼性一ペリオテストとの比較-, 第33回日本口腔インプラント学会総会, (Summary) 1
16.	Kenji Fujisawa, Kazuhiro Yokoyama, Youji Miyamoto, Nobuyuki Kamata and Masaru Nagayama : 薬物療法を行った顎関節症患者の臨床統計的検討, 第16回日本顎関節学会総会, (Summary) 1
17.	Youji Miyamoto, Kenji Fujisawa, Seiko Tatehara, Yukihiro Momota, Tetsuya Yuasa and Masaru Nagayama : ブローネマルクシステムを使用した即時荷重インプラントの13例, 第57回日本口腔科学会総会, (Summary) 1
18.	Eiichiro Kitaoka, Nobuyuki Kamata, Yukihiro Momota, 山之内浩司, Kenji Fujisawa, 瀧雅行, Yoshio Hayashi and Masaru Nagayama : 顎関節に発症した滑膜性軟骨腫症の1例, 第57回日本口腔科学会総会, (Summary) 1
19.	山之内浩司, Nobuyuki Kamata, Yukihiro Momota, Eiichiro Kitaoka, Keiko Kume and Masaru Nagayama : 抗凝固剤維持量投与下における観血的処置の検討, 第57回日本口腔科学会総会, (Summary) 1
20.	瀧雅行, Nobuyuki Kamata, Kazuhiro Yokoyama, 藤本良一, 友成真弓, Hiroyoshi Hosokawa and Masaru Nagayama : 扁平上皮癌細胞における上皮・間葉移行機構およびTGF-βシグナルによるMMP-2の発現制御, 第57回日本口腔科学会総会, (Summary) 1
21.	Tetsuya Yuasa, Youji Miyamoto, Masaaki Takechi, Yukihiro Momota, Seiko Tatehara, Masaru Nagayama and Masayuki Kon : カルシウム溶液処理による表面改質チタンが培養骨芽細胞に及ぼす影響, 第57回日本口腔科学会総会, (Summary) 1
22.	村松亮, Yukihiro Momota, Masaaki Takechi, Hiroaki Nakanishi, Kazuhito Satomura and Masaru Nagayama : 抜歯後異常骨吸収を示した歯性上顎洞炎の1例, 第52回日本口腔科学会地方会, (Summary) 1
23.	久米里織, 友成真弓, 高野栄之, Masaaki Takechi, Hiroaki Nakanishi, Yoshio Hayashi and Masaru Nagayama : 両側性に舌下型ガマ腫を発症したシェーグレン症候群の1例, 第52回日本口腔科学会地方会, (Summary) 1
24.	Kenji Fujisawa, Youji Miyamoto, 日比弓紀子, Masaaki Takechi, Tetsuya Yuasa, Yukihiro Momota, Seiko Tatehara and Masaru Nagayama : 水平的歯槽骨延長を行いインプラントを埋入した1例, 第34回日本口腔インプラント学会総会, (Summary) 1
25.	Hiroaki Nakanishi, Kazuhito Satomura, Yukihiro Momota and Masaru Nagayama : 5-ALAと青紫色ダイオードレーザーを用いた口腔癌蛍光診断システムの開発, 第5回5-ALA研究会, (Summary) 1
26.	Kenji Fujisawa, 前田恵利子, Eiichiro Kitaoka, Hiroaki Nakanishi and Masaru Nagayama : クローズドロック症例の臨床統計的検討, 第17回日本顎関節学会総会, (Summary) 1
27.	前田恵利子, Eiichiro Kitaoka, Nobuyuki Kamata, 山之内浩司, Kenji Fujisawa, Yukihiro Momota, 瀧雅行 and Masaru Nagayama : 細胞生物学的研究を行った顎関節滑膜性軟骨腫症の1例, 第33回日本口腔外科学会地方会, (Summary) 1
28.	Tetsuya Yuasa, Youji Miyamoto, Hiroaki Nakanishi, Kenji Fujisawa, Seiko Tatehara, 瀧雅行 and Masaru Nagayama : 顔面多発骨折の変形治癒に対し顎矯正手術・骨移植術により咀嚼，審美障害の改善を認めた1例, 第6回日本口腔顎顔面外傷学会, (Summary) 1
29.	Hiroaki Nakanishi, Kazuhito Satomura, Yukihiro Momota, Nobuyuki Kamata and Masaru Nagayama : 5-ALAと青紫色ダイオードレーザーを用いた口腔癌蛍光診断システムの開発, 第14回日本光線力学学会, (Summary) 1
30.	瀧雅行, Nobuyuki Kamata, 友成真弓, 堤聡 and Masaru Nagayama : 扁平上皮痛細胞における上皮・間葉移行によるETS-1の発現誘導とその意義, 第58回日本口腔科学会総会, (Summary) 1
31.	Kenji Fujisawa, Tetsuya Yuasa, Nobuyuki Kamata, Youji Miyamoto, Masaru Nagayama, Yukiko Kitase, 掘内信也 and Keiji Moriyama : 口唇口蓋裂に伴う上顎劣成長に対し，RED systemを用いて骨延長を行った2例, 第14回日本顎変形症学会総会, (Summary) 1
32.	友成真弓, Nobuyuki Kamata, Kazuhiro Yokoyama, 瀧雅行, 堤聡 and Masaru Nagayama : 口腔粘膜再構成三次元培養系における口腔癌の浸潤能に及ぼすMT1-MMPおよびMMP-2の作用, 第58回日本口腔科学会総会, (Summary) 1
33.	Hiroaki Nakanishi, Reiko Tokuyama, Kenji Fujisawa, Kazuhito Satomura, Nobuyuki Kamata and Masaru Nagayama : 光線力学療法を応用した口腔粘膜多発癌の1例, 第58回日本口腔科学会総会, (Summary) 1
34.	Reiko Tokuyama, Kazuhito Satomura, 前田恵利子, Keiko Kudoh and Masaru Nagayama : セリンプロテアーゼインヒビターであるマスピンは関節軟骨の安定性に関与している, 第23回日本骨代謝学会学術集会, (Summary) 1
35.	Kenji Fujisawa, Masaaki Takechi, Eiji Yamauchi, Youji Miyamoto, Tetsuya Yuasa, Yukihiro Momota and Masaru Nagayama : 共鳴振動周波数分析装置を用いたインプラント安定性の評価1．Implant StabilityQuotient(ISQ)とインプラントの安定性に関連する因子との比較, 第35回日本口腔インプラント学会総会・学術大会, (Summary) 1
36.	Yukihiro Momota, Youji Miyamoto, 石川邦夫, 南口知穂 and Masaru Nagayama : 骨止血剤(HAP putty)による血小板凝集能の亢進, 第7回日本口腔顎顔面外傷学会総会・学術大会, (Summary) 1
37.	Reiko Tokuyama, Tetsuya Yuasa, 前田恵利子, Masaaki Takechi, Kazuhito Satomura and Masaru Nagayama : TS-1投与と放射線併用療法が著効を示した歯肉扁平上皮癌の1例, 第4回中四国口腔癌研究会学術講演会,
38.	Tetsuya Yuasa, Hiroaki Nakanishi, 日比弓紀子, 友成真弓, Reiko Tokuyama, 前田恵利子, Fumie Omotehara, Yoshio Hayashi and Masaru Nagayama : 耳下腺腫瘍との鑑別が困難であった木村氏病の1例, 第59回日本口腔科学会総会,
39.	高野栄之, Hiroaki Nakanishi, Kazuhito Satomura, Keiko Kudoh and Masaru Nagayama : 青紫レーザーダイオードとファイバー入射型分光器を用いたALA-PDTにおけるプロトポルフイリンIX蓄積の測定, 第21回生体・生理工学シンポジウム, (Summary) 1
40.	高野栄之, Kazuhito Satomura, Keiko Kudoh, Hiroaki Nakanishi, Takaharu Kudoh and Masaru Nagayama : 放射線性口内炎に対する蛍光診断の試み, 第51回日本口腔外科学会総会, (Summary) 1
41.	前田恵利子, Kazuhito Satomura, Reiko Tokuyama, Keiko Kudoh, 山崎泰文 and Masaru Nagayama : マウス骨髄間質細胞の歯原性細胞への分化誘導, 四国歯学会第30回例会・第25回総会, (Summary) 1
42.	高野栄之, Kazuhito Satomura, Keiko Kudoh, Hiroaki Nakanishi and Masaru Nagayama : 青紫レーザーダイオードを利用した放射線性粘膜炎に対する診断システムの開発, 四国歯学会第30回例会・第25回総会, (Summary) 1
43.	Reiko Tokuyama, Kazuhito Satomura, Masaaki Takechi, Tetsuya Yuasa, Keiko Kudoh, Seiko Tatehara, 高野栄之 and Masaru Nagayama : 矯正牽引装置により治療を行った小児外傷性歯牙埋入の1例．, 第8回日本口腔顎顎面外傷学会総会・学術大会, (Summary) 1
44.	Keiko Kudoh, Kazuhito Satomura, 高野栄之, Hiroaki Nakanishi, Takaharu Kudoh, Hitoshi Ikushima and Masaru Nagayama : 放射線性口内炎に対する蛍光診断の可能性, 第16回日本口腔粘膜学会総会・学術集会, (Summary) 1
45.	Yukihiro Momota, Kazuhito Satomura, Masaaki Takechi, Keiko Kudoh, Reiko Tokuyama, 山崎泰文, 小柴邦彦, Kazuya Kondo and Masaru Nagayama : 縦隔膿瘍を発症した下顎智歯周囲炎の1例, 第35回日本口腔外科学会・中四国地方会,
46.	Reiko Tokuyama, Kazuhito Satomura, Masaaki Takechi, Tetsuya Yuasa, Keiko Kudoh, Seiko Tatehara, 高野栄之, 前田恵利子 and Masaru Nagayama : セルフドリリングタイプ顎間固定用スクリューの有用性に関する臨床的および実験的検討, 第60回日本口腔科学会総会, (Summary) 1
47.	前田恵利子, Kazuhito Satomura, Reiko Tokuyama, Keiko Kudoh, 山崎泰文 and Masaru Nagayama : マウス骨髄間質細胞の外胚葉系細胞への分化誘導, 第60回日本口腔科学会総会, (Summary) 1
48.	Hiroyoshi Hosokawa, Kazuhito Satomura, Keiko Kudoh, Seiko Tatehara, Reiko Tokuyama, Tetsuya Yuasa, 高野栄之 and Masaru Nagayama : 悪性腫瘍を疑った難治性上顎骨骨髄炎の1例, 第36回(社)日本口腔科学会中・四国地方会,
49.	Hiroyoshi Hosokawa, Kazuhito Satomura, Keiko Kudoh, Seiko Tatehara, Reiko Tokuyama, Hideyuki Takano, Masaru Nagayama, Naozumi Ishimaru and Yoshio Hayashi : 頬粘膜に発生した血管筋腫の1例, Journal of The Japanese Stomatological Society, Vol.57, No.3, 348, Jul. 2008.
50.	Keiko Kudoh, Kazuhito Satomura, Hiroyoshi Hosokawa, Seiko Tatehara, Reiko Tokuyama and Masaru Nagayama : 鼻腔内逆生歯の1例, Journal of The Japanese Stomatological Society, Vol.57, No.3, 352, Jul. 2008.
51.	Hiroyoshi Hosokawa, Kazuhito Satomura, Keiko Kudoh, Seiko Tatehara, Reiko Tokuyama, 高野栄之, Naozumi Ishimaru, Yoshio Hayashi and Masaru Nagayama : 頬粘膜に発生した血管筋腫の1例, Journal of The Japanese Stomatological Society, Vol.57, No.3, 348, Jul. 2008.
52.	Hideyuki Takano, Hiroaki Nakanishi, Tetsuya Yuasa, Keiko Kudoh and Masaru Nagayama : 左側耳下腺部に発生した軟部好酸球肉芽腫症の治療経験, Journal of The Japanese Stomatological Society, Vol.57, No.1, 150, Jan. 2008.
53.	Hiroyoshi Hosokawa, Kazuhito Satomura, Yukihiro Momota, Keiko Kudoh, Seiko Tatehara, Reiko Tokuyama, Hideyuki Takano, Naozumi Ishimaru, Yoshio Hayashi, Masaru Nagayama and 第17回日本口腔粘膜学会 : 口腔白板症の臨床病理学的検討, 第17回日本口腔粘膜学会 2007.7.5∼7.6,東京, Jul. 2007.
54.	Reiko Tokuyama, Keiko Kudoh, Seiko Tatehara, Hideyuki Takano and Masaru Nagayama : 舌骨骨折を伴った顎骨骨折の1例, Japanese Society of Oral and Maxillofacial Traumatology, Vol.6, No.1, 30, Jun. 2007.
55.	Shinya Horiuchi, Takumi Takahashi, Keiji Moriyama, Tetsuya Yuasa, Masaru Nagayama, Kazuya Matsumoto and Hideki Nakanishi : 顔面多発骨折による咬合不全に対して集学的治療を行った1症例, 日本頭蓋顎顔面外科学会雑誌, Vol.23, No.2, 163-164, Jun. 2007.
56.	南口知穂, Masaaki Takechi, Tetsuya Yuasa, Yukihiro Momota, Seiko Tatehara, Hideyuki Takano, 石川邦夫, Youji Miyamoto and Masaru Nagayama : 低結晶性炭酸アパタイト含有PLGA複合体が多核巨細胞に与える影響, 第60回日本口腔科学会総会, Jan. 2007. (Summary) 1
57.	Yukihiro Momota, Youji Miyamoto, 石川邦夫, Masaaki Takechi, Tetsuya Yuasa, 舘原誠晃, Hideyuki Takano, 南口知穂 and Masaru Nagayama : HAP Putty(骨止血剤)が血小板凝集および血小板由来増殖因子の分泌に及ぼす影響．, 第60回日本口腔科学会総会, Jan. 2007. (Summary) 1
58.	Shinya Horiuchi, Takumi Takahashi, Keiji Moriyama, Tetsuya Yuasa, Masaru Nagayama, Kazuya Matsumoto and Hideki Nakanishi : 顔面多発骨折による咬口不全に対して集学的治療を行った1症例, 第24回日本頭蓋顎顔面外科学会, Nov. 2006.
59.	山崎泰文, Reiko Tokuyama, Tetsuya Yuasa, Hiroaki Nakanishi and Masaru Nagayama : 頬粘膜に発生した上皮異形成を伴う疣贅型黄色腫の1例, 第54回NPO法人日本口腔科学会中国・四国地方部会, Nov. 2006.
60.	山崎泰文, Kazuhito Satomura, Seiko Tatehara, Tetsuya Yuasa, Keiko Kudoh, Reiko Tokuyama, 前田恵理子 and Masaru Nagayama : 顎下腺管内唾石の成分分析一骨関連非コラーゲン性タンパク質の局在-, 第51回日本口腔外科学会総会, Oct. 2006. (Summary) 1
61.	Fumihiro Matsumoto, Teruaki Ishikawa, Hisahiro Takeuchi, Kenji Fujisawa, Hidehiko Hosoki, Masaru Hada, Masanori Nakano and Masaru Nagayama : Research on the actual application of the TMD reporting system of Tokushima University Hospital, Journal of the Japanese Society for the Temporomandibular Joint, Vol.19, No.1, 81, Jul. 2006.
62.	Keiko Kudoh, Kazuhito Satomura, Takaharu Kudoh, Hitoshi Ikushima and Masaru Nagayama : 放射線性口内炎に対する蛍光診断の可能性, Jun. 2006.
63.	山之内浩司, Keiko Kudoh, 高野栄之, 前田恵利子 and Masaru Nagayama : 外傷性上唇動脈瘤の1例, Japanese Journal of Oral & Maxillofacial Surgery, Vol.51, 111, Oct. 2005.
64.	Chieko Sugawara, Hirokazu Iwasaki, Keiko Kudoh, Masaru Nagayama and Yoshio Hayashi : 舌悪性腫瘍により内頸静脈腫瘍塞栓をきたした症例の画像所見, Japanese Journal of Oral & Maxillofacial Surgery, Vol.51, 94, Oct. 2005.
65.	前田恵利子, Kazuhito Satomura, Reiko Tokuyama, 瀧雅行, Keiko Kudoh, 山崎泰文, Nobuyuki Kamata and Masaru Nagayama : マウス骨髄間質細胞の歯原性細胞への分化誘導, Oct. 2005.
66.	山之内浩司, Keiko Kudoh, 高野栄之, 前田恵利子 and Masaru Nagayama : 外傷性上唇静脈瘤の1例, Oct. 2005.
67.	前田恵利子, Kazuhito Satomura, 徳山麗子, 瀧雅行, Keiko Kudoh, 山崎泰文, 鎌田伸之 and Masaru Nagayama : マウス骨髄間質細胞の歯原性細胞への分化誘導, Japanese Journal of Oral & Maxillofacial Surgery, No.51, 190, Oct. 2005.
68.	Hiroyoshi Hosokawa, Kikuji Yamashita, 石橋淳, Seiichiro Kitamura and Masaru Nagayama : 癌細胞の特性遠赤外線に対する感受性とストレス蛋白との関係, 第50回日本口腔外科学会総会, Oct. 2005.
69.	Kikuji Yamashita, 石橋淳, Hiroyoshi Hosokawa, 石川七生, Hiroyuki Morimoto, 石川友康, Masaru Nagayama and Seiichiro Kitamura : 特性遠赤外線照射MC3T3-E1, 第14回硬組織再生生物学会, Sep. 2005.
70.	Seiko Tatehara, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Hideyuki Takano, Youji Miyamoto and Masaru Nagayama : bFGF合浸Hap-PLGA複合体における骨組織反応について, 第50回(社)日本口腔外科学会総会, Sep. 2005. (Summary) 1
71.	Hideyuki Takano, Masaaki Takechi, Seiko Tatehara, 南口知穂, Yukihiro Momota, Tetsuya Yuasa and Masaru Nagayama : オッセオインテグレーションにおけるリセドロネートとヒト塩基性線維芽細胞成長因子の促進効果, 第35回日本口腔インプラント学会総会・学術大会, Sep. 2005.
72.	南口知穂, Masaaki Takechi, Tetsuya Yuasa, Yukihiro Momota, Seiko Tatehara, Hideyuki Takano, Youji Miyamoto, Kazuhito Satomura and Masaru Nagayama : 骨組織再生におけるHAP-PLGA複合体の有用性に関する基礎研究, 第59回日本口腔科学会総会, Sep. 2005. (Summary) 1
73.	Takaharu Kudoh, Keiko Kudoh, Tetsuya Yuasa, Kyosuke Osaki, Hitoshi Ikushima, Masaru Nagayama and Eiichi Honda : 上歯肉扁平上皮癌に対する高線量率モールド照射の治療経験, Shikoku Dental Research, Vol.18, No.2, 253, Jun. 2005. (Tokushima University Institutional Repository) ● Metadata: 273 (Tokushima University Institutional Repository: 273)
74.	Kazuyuki Kaneko, 内田玲子, Akihiro Yasue, Yasuo Oba, Kenji Fujisawa, Masaru Nagayama and Keiji Moriyama : PLLA製スクリューを用いて下顎枝矢状分割術を行った下顎非対称を伴う下顎前突症患者における術後安定性-正面頭部X線規格写真を用いた検討-, 第15回日本顎変形症学会総会, Jun. 2005.
75.	Yasuo Oba, Akihiro Yasue, Kazuyuki Kaneko, 内田玲子, Kenji Fujisawa, Masaru Nagayama and Keiji Moriyama : PLLA製スクリューを用いた下顎枝矢状分割術後の近位・遠位骨片の術後変化-手術後の骨片の回転変化に関する検討-, 第15回日本顎変形症学会総会, Jun. 2005.
76.	Yukihiro Momota, Youji Miyamoto, 石川邦夫, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara, Hideyuki Takano, 南口知穂 and Masaru Nagayama : 骨止血剤(HAP putty)による血小板凝集能の亢進, Japanese Society of Oral and Maxillofacial Traumatology, Vol.4, No.1, 24-25, Jun. 2005.
77.	太田真弓, Masaaki Takechi, Kazuhito Satomura and Masaru Nagayama : 下顎骨に多発した単純性骨嚢胞の1例, 第34回(社)日本口腔外科学会中・四国地方会, Jun. 2005.
78.	高野栄之, Masaaki Takechi, Kazuhito Satomura and Masaru Nagayama : 舌に発生した対称性脂肪腫症の1例, 第34回(社)日本口腔外科学会中・四国地方会, May 2005.
79.	Hiroyoshi Hosokawa, Kikuji Yamashita, 石橋淳, Masaru Nagayama and Seiichiro Kitamura : 癌細胞の特性赤外線に対する感受性とストレス蛋白との関係, 第50回(社)日本口腔外科学会総会大阪国際会議場,2005., 2005.
80.	瀧雅行, Nobuyuki Kamata, 友成真弓 and Masaru Nagayama : 扁平上皮癌細胞における上皮・間葉移行に伴うWnt-5aの発現誘導の意義, 第63回日本癌学会総会, Sep. 2004.
81.	Hiroaki Nakanishi, Tetsuya Yuasa, Kazuhito Satomura and Masaru Nagayama : 5-アミノレブリン酸を用いて光線力学療法と蛍光診断を行った口腔白板症の1例, 第14回日本口腔粘膜学会総会, Jul. 2004.
82.	瀧雅行, Nobuyuki Kamata, 友成真弓 and Masaru Nagayama : 扁平上皮癌細胞における上皮・間葉移行による悪性度上昇機構の解明, 第77回日本組織培養学会, May 2004. (Summary) 1
83.	Nobuyuki Kamata, Satoshi Tutumi, Yutaka Maruoka, Koichi Nakakuki, Masami Ninomiya, Yuji Kabasawa, Syunpei Yamada, Kazuto Kurohara, Ken Omura, Teruo Amagasa, Toshihiko Nagata, Masaru Nagayama and Mitsuo Itakura : 顎骨の骨およびセメント質形成病変における遺伝子変異検索, The 58th Annual Meeting of The Japanese Stomatological Society, 132, May 2004.
84.	Hideyuki Takano, Youji Miyamoto, Kenji Fujisawa, Tetsuya Yuasa, Yukihiro Momota and Masaru Nagayama : 歯科インプラントのオッセオインテグレーション喪失に関する臨床統計学的検討, 第32回日本口腔外科学会中国四国地方部会, Jan. 2004. (Summary) 1
85.	Hiroyoshi Hosokawa, Kikuji Yamashita, 石橋淳, 山内里津, Seiichiro Kitamura and Masaru Nagayama : 特性遠赤外線による腫瘍細胞増殖抑制効果の解析．, 6th Asian Congress on Oral and Maxillofacial Surgery，第49回日本口腔外科学会総会, 2004.
86.	瀧雅行, Nobuyuki Kamata, Kazuhiro Yokoyama, 堤聡, 友成真弓 and Masaru Nagayama : 扁平上皮癌細胞における上皮・間葉移行およびTGF-βによるケモカインとその受容体の発現制御, 第48回日本口腔外科学会総会, Oct. 2003.
87.	Kazuhiro Yokoyama, Nobuyuki Kamata, 瀧雅行, 堤聡, 友成真弓 and Masaru Nagayama : 口腔扁平上皮癌における上皮・間葉系移行関連Snailのプロモータ領域の解析, 第48回日本口腔外科学会総会, Oct. 2003.
88.	堤聡, Nobuyuki Kamata, 丸岡豊, 中久木康一, 榎本昭二, 小村健, 天笠光雄, Masaru Nagayama, Takashi Yamaoka and Mitsuo Itakura : 新規骨系統疾患Gnathodiaphyseal Dysplasia遺伝子のポジショナルクローニング, 第48回日本口腔外科学会総会, Oct. 2003.
89.	Kazuhiro Yokoyama, Nobuyuki Kamata, 瀧雅行, 堤聡, 友成真弓 and Masaru Nagayama : 扁平上皮癌細胞におけるSnail発現に村するサイトカインの影響, 第62回日本癌学会総会, Sep. 2003.
90.	瀧雅行, Nobuyuki Kamata, Kazuhiro Yokoyama, 堤聡, 友成真弓 and Masaru Nagayama : 扁平上皮癌細胞の上皮・間葉移行におけるSnailとTGF-βシグナルのクロストーク, 第62回日本癌学会総会, Sep. 2003.
91.	瀧雅行, Nobuyuki Kamata, Kazuhiro Yokoyama and Masaru Nagayama : 扁平上皮癌細胞における上皮・間葉移行による悪性化とその分子機構, 第76回日本組織培養学会, May 2003.
92.	Reiko Tokuyama, Kazuhito Satomura, 飛梅悟, 山之内浩司, Keiko Kume, Eiichiro Kitaoka, 西庄佐智子, 増田尚子, 日比弓紀子 and Masaru Nagayama : ヒト骨髄間質細胞の増殖分化に対するメラトニンの影響, 第47回日本口腔外科学会, Oct. 2002. (Summary) 1
93.	西庄佐智子, Kazuhito Satomura, Keiko Kume, Eiichiro Kitaoka, 飛梅悟, Reiko Tokuyama, 日比由紀子 and Masaru Nagayama : 卵巣摘出マウス骨組織におけるレプチンの免疫組織学的検討, 第47回日本口腔外科学会, Oct. 2002. (Summary) 1
94.	藤本良一, Nobuyuki Kamata, 瀧雅行, 友成真弓, Kazuhiro Yokoyama, Masaru Nagayama and 安本茂 : ヒト正常上皮細胞の老化，不死化におけるテロメラーゼ関連遺伝子の発現, 第12回日本口腔粘膜学会, Jul. 2002.
95.	瀧雅行, Tetsuya Yuasa, Nobuyuki Kamata, 日比弓紀子 and Masaru Nagayama : Bernard-Soulier症候群患者の抜歯の1例, 第31回日本口腔外科学会中・四国地方会, Jun. 2002. (Summary) 1
96.	瀧雅行, Nobuyuki Kamata, Kazuhiro Yokoyama, 藤本良一, 堤聡, 友成真弓 and Masaru Nagayama : 扁平上皮癌細胞における上皮間葉移行によるWnt-4及びWnt-5a遺伝子発現の変化, 第75回日本組織培養学会, May 2002.
97.	Hiroaki Nakanishi, Rogers Louls, Butler R Anthony, MacRobrt J Alexander and Masaru Nagayama : 培養角化細胞での新規5-ALA誘導体による細胞内PPIX蓄積および光毒性の増強効果, 第12回光線力学学会, May 2002.
98.	Hiroyoshi Hosokawa, Kazuhiro Yokoyama, 武知正晃, Kazuhito Satomura, Nobuyuki Kamata and Masaru Nagayama : 再生不良性貧血を合併した上顎洞癌の1例, 第50回日本口腔科学会中国四国地方部会, 2002.
99.	Nobuyuki Kamata, Masami Ninomiya, Tomoko Azuma, 藤本良一, Toshihiko Nagata and Masaru Nagayama : 智歯·埋伏歯の移植歯への応用, 四国歯学会第25回例会·第20回総会, Jun. 2001.
100.	Nobuyuki Kamata, Masami Ninomiya, 藤本良一, 友成真弓, Toshihiko Nagata and Masaru Nagayama : 智歯·埋伏歯の移植術へのエムドゲインの応用, 第55回日本口腔科学会総会, Apr. 2001.
101.	Kenji Fujisawa, Youji Miyamoto, Seiko Tatehara, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Masaru Nagayama, Kazuo Okura, Eiji Yamauchi, Motoharu Kori, 松浦広輿, Eiichi Bando and 池田隆志 : 眼窩エピテーゼの維持源にオッセオインテグレーティツドインプラントを応用した1例, 第21回日本口腔インプラント学会中国・四国支部総会・学術大会, 2001. (Summary) 1
102.	日比弓紀子, Kenji Fujisawa, Tetsuya Yuasa, Naozumi Ishimaru and Masaru Nagayama : 歯肉増殖を伴ったSturge-Weber症候群の1例, 第49回日本口腔科学会中国・四国地方部会, 2001. (Summary) 1
103.	Youji Miyamoto, Kenji Fujisawa, Tetsuya Yuasa, Yukihiro Momota, Masaaki Takechi, Masaru Nagayama, Eiji Yamauchi, Eiichi Bando and Daisuke Hinode : 下顎無歯顎インプラント患者のオトガイ孔後方へのfixture埋入は是か非か?, 第31回日本口腔インプラント学会総会・学術大会, 2001. (Summary) 1
104.	Seiko Tatehara, Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, 増田尚子 and Masaru Nagayama : インプラント型仮骨延長器による垂直的歯槽骨延長の経験, 第46回(社)日本口腔外科学会総会, 2001. (Summary) 1
105.	西庄佐智子, Kazuhito Satomura, Eiichiro Kitaoka, 増田尚子, 合田大亮, Reiko Tokuyama, Keiko Kume, 飛梅悟 and Masaru Nagayama : 線維性骨異形成症および化骨性線維腫の病因に関する細胞生物学的検討, 第19回日本骨代謝学会, 2001. (Summary) 1
106.	Eiichiro Kitaoka, Kazuhito Satomura, Keiko Kume, 西庄佐智子, 林英司, Nobuyuki Kamata, Masaru Nagayama and 帯刀益夫 : SV40T抗原トランスジェニツクマウス肋軟骨由来の軟骨細胞株の樹立とその性状, 第74回日本組織培養学会, 2001. (Summary) 1
107.	Kenji Fujisawa, 住友孝史, 合田大亮, 友成真弓, 小積麻衣子, Nobuyuki Kamata and Masaru Nagayama : 当科における顎関節症患者の臨床統計的検討, 第14回日本顎関節学会総会, 2001. (Summary) 1
108.	Keiko Kume, Kazuhito Satomura, Eiichiro Kitaoka, 西庄佐智子, 増田尚子, 合田大亮, Reiko Tokuyama, 飛梅悟 and Masaru Nagayama : 骨折治癒過程におけるレプチンの発現局在, 第19回日本骨代謝学会, 2001. (Summary) 1
109.	Kenji Fujisawa, 増田尚子, 飛梅悟, Seiko Tatehara, Yukihiro Momota, 林英司, Nobuyuki Kamata and Masaru Nagayama : 下顎骨関節突起骨折の臨床統計的検討, 第3回口腔顎顔面外傷研究会, 2001. (Summary) 1
110.	Yukihiro Momota, Nobuyuki Kamata, Kazuhito Satomura and Masaru Nagayama : 上顎洞アスペルギルス症の原因菌種の同定-PCR法を用いた検索-, 第30回(社)日本口腔外科学会中国・四国地方会, 2001. (Summary) 1
111.	飛梅悟, Kazuhito Satomura, 山之内浩司, Eiichiro Kitaoka, Keiko Kume and Masaru Nagayama : メラトニンのヒト骨芽細胞に対する影響, 第55回日本口腔科学会総会, 2001. (Summary) 1
112.	Kenji Fujisawa, Youji Miyamoto, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, 藤武智, 増田尚子, Seiko Tatehara and Masaru Nagayama : ブローネマルクインプラントの臨床統計学的検討一上部構造装着後のフイクスチャー除去症例について-, 第55回日本口腔科学会総会, 2001. (Summary) 1
113.	Yoshiko Noda, Yukihiro Momota, Kazuhito Satomura, 鎌田伸之, Naozumi Ishimaru and Masaru Nagayama : 上顎洞に発症したアスペルギルス症の1例 : 血清学的検査の有用性についての考察, 第45回日本口腔外科学会総会, Oct. 2000.
114.	Seiko Tatehara, Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, 藤武智, 飛梅悟, 増田尚子, Masaru Nagayama, Motoharu Kori, 松浦広輿, Eiji Yamauchi, Kazuo Okura and Daisuke Hinode : 当科におけるブローネマルクインプラントの臨床統計的検討-Osseointegration獲得に関与する因子について-, 第20回日本口腔インプラント学会中国・四国支部総会・学術大会, 2000. (Summary) 1
115.	山之内浩司, 布袋屋智朗, Nobuyuki Kamata, Yukihiro Momota, Keiko Kume, 林英司 and Masaru Nagayama : 生体吸収性ポリーL乳酸(PLLA)骨接合ミニプレートによる下顎骨骨折の治療経験, 第20回日本口腔インプラント学会中国・四国支部総会・学術大会, 2000. (Summary) 1
116.	合田大亮, Kenji Fujisawa, Youji Miyamoto, Masaaki Takechi, 林英司 and Masaru Nagayama : PLLA(ポリ-L-乳酸)メッシュトレイおよび新鮮自家腸骨海綿骨細片移植による下顎再建後にインプラントを応用した1例, 第20回日本口腔インプラント学会中国・四国支部総会・学術大会, 2000. (Summary) 1
117.	Yukihiro Momota, Yoshiko Noda, Kazuhito Satomura, Nobuyuki Kamata, Masaru Nagayama and Naozumi Ishimaru : 上顎洞に発症したアスペルギルス症の2例-PCR法を用いた遺伝子診断-, 第45回日本口腔外科学会総会, 2000.
118.	Youji Miyamoto, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, 藤武智, Masaru Nagayama and Masayuki Kon : カルシウム溶液処理によるチタン表面の改質と疑似体液中における挙動, 第45回日本口腔外科学会総会, 2000. (Summary) 1
119.	藤武智, Youji Miyamoto, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Masaru Nagayama, 石川邦夫 and Kazuomi Suzuki : 炭酸水素ナトリウムを用いた骨置換型アパタイトセメントー培養破骨細胞による吸収性の評価-, 第45回日本口腔外科学会総会, 2000. (Summary) 1
120.	Keiko Kume, Kazuhito Satomura, Eiichiro Kitaoka, 西庄佐智子, 山之内浩司, 飛梅悟 and Masaru Nagayama : マウス内軟骨性骨化におけるレプチンの役割, 第45回日本口腔外科学会総会, 2000. (Summary) 1
121.	Masaaki Takechi, Youji Miyamoto, Kenji Fujisawa, Yukihiro Momota, Tetsuya Yuasa, 藤武智, Masaru Nagayama, 鈴木温 and Daisuke Hinode : 当科におけるインプラント失敗例に関する臨床的検討一上部構造装着前の失敗症例について一, 第30回日本口腔インプラント学会総会・学術大会, 2000. (Summary) 1
122.	Youji Miyamoto, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, 藤武智 and Masaru Nagayama : 急速アパタイト転換型リン酸カルシウムセメントの開発, 第30回日本口腔インプラント学会総会・学術大会, 2000. (Summary) 1
123.	Eiichiro Kitaoka, Kazuhito Satomura, Keiko Kume, 飛梅悟, 山之内浩司, 林英司, Masaru Nagayama and 帯刀益夫 : SV40T抗原トランスジェニツクマウス肋軟骨由来の軟骨細胞株の樹立とその性状, 日本組織培養学会第73回大会, 2000. (Summary) 1
124.	新田幸司, Yukihiro Momota, Kazuhito Satomura, 林英司, Nobuyuki Kamata, Masaru Nagayama, 柳久美子 and 林良夫 : 口腔白板症の臨床病理学的検討, 第10回日本口腔粘膜学会総会, 2000. (Summary) 1
125.	山之内浩司, Kazuhito Satomura, Kenji Fujisawa, Youji Miyamoto, Masaru Nagayama and Katsuhiko Nakamura : 確定診断に至らなかった難治性口内炎の1例, 第10回日本口腔粘膜学会総会, 2000. (Summary) 1
126.	林英司, Kenji Fujisawa, Nobuyuki Kamata and Masaru Nagayama : 口腔顎頗面外科におけるバイポーラシザーズ(Power Star) の使用経験, 第54回日本口腔科学会総会, 2000. (Summary) 1
127.	Yoshiko Noda, Kenji Fujisawa, 小積麻衣子, Nobuyuki Kamata, Masaru Nagayama and Yoshio Hayashi : 下顎骨に発生した形質細胞腫の1例, 第29回日本口腔外科学会中国四国地方会, 2000. (Summary) 1
128.	Reiko Tokuyama, Hiroaki Nakanishi, Kenji Fujisawa, Yoshio Hayashi and Masaru Nagayama : 長期経過をたどった口腔粘膜多発癌の1例, 第49回日本口腔科学会中国・四国地方部会, 2000. (Summary) 1
129.	小積麻衣子, 林英司, 中西宏彰, Masaru Nagayama, Fumihiro Matsumoto, 多田羅勝義 and 水谷滋 : 進行性筋ジストロフィー患者の口腔内所見ー診断用模型による形態学的検討ー, Japanese Journal of Oral & Maxillofacial Surgery, Oct. 1999.
130.	松木弘量, Hitoshi Ikushima, Hiromu Nishitani, Yoshihiro Takegawa, Masaru Nagayama and Mitsunobu Sato : 舌癌の放射線治療成績, 第218回徳島医学会, Jan. 1999.
131.	布袋屋智朗, Fumihiro Matsumoto, 林英司 and Masaru Nagayama : 舌，食道，胃にみられた三重複癌の1例, Japanese Journal of Oral & Maxillofacial Surgery, Jul. 1996.
132.	Fumihiro Matsumoto, 野沢孝行, Kenji Fujisawa and Masaru Nagayama : ラット顎関節における神経ペプチドの発現に関する研究, Journal of the Japanese Society for the Temporomandibular Joint, Jul. 1996.
133.	Yoshihiro Takegawa, 柏原賢一, 小池靖夫, Masaru Nagayama and Mitsunobu Sato : 舌扁平上皮癌の治療成績, 第18回日本頭頸部腫瘍学会(札幌), Jun. 1994.
134.	Fumihiro Matsumoto, 中西淳仁, Kenji Fujisawa and Masaru Nagayama : 臼歯抜歯により生ずる顎関節滑膜の組織学的変化, Journal of the Japanese Society for the Temporomandibular Joint, Jul. 1993.
135.	中西淳仁, Fumihiro Matsumoto, 布袋屋智朗, 力丸浩一 and Masaru Nagayama : 扁平上皮癌におけるP53の免疫組織学的検討, Japanese Journal of Oral & Maxillofacial Surgery, Nov. 1992.
136.	林英司, Fumihiro Matsumoto, 力丸浩一, Masaru Nagayama and 西田敏信 : 口腔癌における血清PTHrPと高カルシウム血症の関連, Japanese Journal of Oral & Maxillofacial Surgery, Nov. 1992.
137.	鴨田保彦, 今城孝憲, Fumihiro Matsumoto, 力丸浩一 and Masaru Nagayama : 下顎骨中心性に発症した神経鞘腫の1例, Journal of The Japanese Stomatological Society, Oct. 1992.
138.	Yoshihiro Takegawa, Masafumi Harada, Masaru Nagayama and Mitsunobu Sato : 口腔癌の放射線治療における柴朴湯の臨床的検討, 第43回日本東洋医学会学術総会(横浜) 1992.5, 講演要旨集, 79, May 1992.
139.	Fumihiro Matsumoto, 中西淳仁, Kenji Fujisawa, Masaru Nagayama, 高木康里 and Hidehiko Hosoki : 当科における顎関節症の臨床的検討:X線検査で顎関節骨構造に異常のみられた症例, Journal of the Japanese Society for the Temporomandibular Joint, Jul. 1991.
140.	Fumihiro Matsumoto, 平岩清貴 and Masaru Nagayama : 低カルシウム食飼育成長期ラットにおける下顎頭軟骨細胞の組織学的研究, Japanese Journal of Oral & Maxillofacial Surgery, Vol.36, No.13, 3160, Oct. 1990.
141.	中西淳仁, 安田勝裕, Fumihiro Matsumoto and Masaru Nagayama : 顎関節症における心理的要因の考察, Journal of the Japanese Society for the Temporomandibular Joint, Jul. 1990.
142.	Fumihiro Matsumoto, 平岩清貴 and Masaru Nagayama : 低Ca食飼育ラットにおける下顎頭軟骨の組織学的および組織化学的研究, Journal of the Japanese Society for the Temporomandibular Joint, Jul. 1989.
143.	中西淳仁, Fumihiro Matsumoto, 安田勝裕 and Masaru Nagayama : 顎関節症発症に関する心因性要因の検討, Japanese Journal of Oral & Maxillofacial Surgery, Vol.36, No.1, 205, Jun. 1989.
144.	Fumihiro Matsumoto, 平岩清貴 and Masaru Nagayama : 成長期ラット下顎頭への低Ca食の影響, Japanese Journal of Oral & Maxillofacial Surgery, Sep. 1988.
145.	Fumihiro Matsumoto, 林英司, 安田勝裕, 吉田幸子 and Masaru Nagayama : 下顎骨に発生した単純性骨嚢胞の2例, Journal of The Japanese Stomatological Society, Vol.37, 791, Oct. 1987.
146.	Inoue Shino, Nobuyuki Kamata, Kazuhiro Yokoyama, Tobiume Satoru, Masaru Nagayama, Hiroaki Kohno, Hirotsugu Takiwaki, Takushi Naroda and Susumu Kagawa : 上顎歯肉，陰茎，腎，大腸に生じた異時性4重複癌の1例, The 32^th Chugoku-Shikoku Branch Meeting of Japanese Stomatological Society, Nov. 1984. (Summary) 1

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

Induced Odontogenic Differentiation of Bane Marrow Strome-derived Stem Cells and Their Possiblity for Teeth Regeneration (Project/Area Number: 19390518 )
エピジェネティクスを応用した幹細胞の創製とそれを用いた再生医療実現の可能性 (Project/Area Number: 18659600 )
顎骨骨幹異形成症の原因遺伝子の同定と機能解析 (Project/Area Number: 16659555 )
末梢血中に存在する体性幹細胞の分離・同定とその再生医療への応用の可能性 (Project/Area Number: 16659554 )
Mechanisms of multipotency of adult stem cells derived from bone marrow stroma and peripheral blood and their application for regenerative medicine (Project/Area Number: 16390591 )
口腔癌の蛍光診断および光線力学治療の開発とその細胞生物学的検討 (Project/Area Number: 14657528 )
Cyto-biological study for growth mechanism of oral squamous cell carcinoma cells in protein-free culture (Project/Area Number: 12470440 )
Effects of Cytokines on the Proliferation Mechanism of Oral Cancer and Oral Epithelial Cells (Project/Area Number: 09470457 )
Application of anti-washout type fast-setting calcium phosphate cement for the reconstruction of jaw bone (Project/Area Number: 07557280 )
Basic Study of Suitable Condition for Bone Formation by Human Osteoblasts and Clinical Application (Project/Area Number: 07457613 )
Studies on the Moleculur and Biological Features of Oral Cancer Cells for the Developments of the Gene Diagnosis (Project/Area Number: 04557090 )
Biological and clinical study on regulation of gene expression in osteoblast and its osteogenesis (Project/Area Number: 03454468 )
口腔外科領域に適用される磁場治療の生体影響に関する基礎的研究 (Project/Area Number: 02670900 )
Analysis of anti-cancer factor and transformation of human hybrid cells between salivary gland cells and oral cancer cells (Project/Area Number: 62570902 )
Celluar Biological Analysis on the Mechanism of Mineralization of Human Bone Tissue and its Application for Reconstruction of Human Tissue in Vitro (Project/Area Number: 62440077 )
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Professor Emeritus : Nagayama, Masaru

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Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)