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Research Activity

His Web Page

Field of Study

Pathology, Immunology

Subject of Study

自己免疫疾患の病因に関する研究 (autoimmune, 病因, 自己抗原)

Book / Paper

Book:

1. Yoshio Hayashi and Naozumi Ishimaru :
Handbook on Immunosenescence,
Springer Japan, Apr. 2009.
2. Yoshio Hayashi and Naozumi Ishimaru :
口唇腺生検病理診断 「シェーグレン症候群の診断と治療マニュアル」,
株式会社 診断と治療社, Tokyo, Apr. 2009.
3. Yoshio Hayashi and Naozumi Ishimaru :
Autoimmunity-Aging Mouse Model for Autoimmune Diseases,
Jan. 2009.
4. Naozumi Ishimaru, 岸本 英博 and Yoshio Hayashi :
T細胞レセプターシグナルとNF-κB,
2007.
5. Yoshio Hayashi :
組織病理アトラス,
文光堂, Tokyo, Apr. 2005.
6. Yoshio Hayashi :
シェーグレン症候群の基礎と臨床,
Iyaku Journal Co., Ltd., Osaka, Nov. 2003.
7. Yoshio Hayashi :
長寿科学辞典,
IGAKU-SHOIN Ltd.Tokyo,Japan, Tokyo, Apr. 2003.
8. Yoshio Hayashi :
長寿科学辞典,
IGAKU-SHOIN Ltd.Tokyo,Japan, Tokyo, Apr. 2003.
9. Yoshio Hayashi :
生物学データ大百科辞典,
朝倉書店, Tokyo, Jun. 2002.
10. Yoshio Hayashi :
標準病理学 第二版,
IGAKU-SHOIN Ltd.Tokyo,Japan, Tokyo, Apr. 2002.
11. Yoshio Hayashi :
シェーグレン症候群へのStrategy,
SENTAN IGAKU-SHA, Tokyo, 2002.
12. Yoshio Hayashi :
歯学生のための病理学 第二版,
Ishiyaku Publishers,Inc., Tokyo, May 1999.
13. Yoshio Hayashi :
歯と口と健康,
Ishiyaku Publishers,Inc., Tokyo, 1998.
14. Yoshio Hayashi :
自己免疫(共著),
長寿科学研究エンサイクロペデイア, 1997.
15. Yoshio Hayashi :
サイトカイン,
長寿科学研究エンサイクロペデイア, 1997.
16. Yoshio Hayashi :
口腔病理組織アトラス,
文光堂, Tokyo, 1997.
17. Yoshio Hayashi :
標準病理学 第一版,
IGAKU-SHOIN Ltd.Tokyo,Japan, Tokyo, 1997.
18. Mitsuo Itakura, Maki Moritani, Fumi Tashiro, Chikara Hashimoto, Jun-ichi Miyazaki, Setsuko Ii, Eiji Kudo, Hiroyuki Iwahana, Yoshio Hayashi, Toshiaki Sano and Katsuhiko Yoshimoto :
Paracrine IL-10 Accelerates Autoimmune Insulitis and Diabetes in Transgenic NOD mice,
Elsevier Science Publishers, Amsterdam, Jan. 1995.
19. Yoshio Hayashi :
シューグレン症候群がわかる(共訳),
株式会社 診療新社, 1994.
20. M Itakura, M Moritani, F Tashiro, C Hashimoto, J Miyazaki, S Li, E Kudo, H Iwahana, Yoshio Hayashi, T Sano and K Yoshimoto :
Diabetes, --- Pancreatic IL-10 accelerates autoimmune insulitis and diabetes in transgenic NOD mice ---,
Elsevier Science, 1994.
21. Yoshio Hayashi, N Haneji and H Hamano :
Transfer of murine Sjogren-like autoimmune lesions to SCID mice and its prevention by anti-CD4 and -TCRV β8 treatment,
State of Art, 1994.
22. Yoshio Hayashi :
歯科医学・歯科医療総論,
Ishiyaku Publishers,Inc., Tokyo, 1990.
23. Yoshio Hayashi :
老化と免疫,
Japan Scientific Societies Press, Tokyo, 1990.
24. Mitsunobu Sato, Yoshio Hayashi and Hideo Yoshida :
Immunopharmacological aspects of OK-432 in humans, --- Effect of immuno-therapy with streptococcal preparation,OK-432, on the peripheral killer lymphocyte population in patients with head and neck cancer ---,
1986.
25. Mitsunobu Sato, Yoshio Hayashi and Hideo Yoshida :
Recent Advances in Chemotherapy, --- Effect of postoperative immunotherapy with streptpcoccal preparation OK-432 on different immunologic parameters in patients with head and neck cancer ---,
1985.

Academic Paper (Judged Full Paper):

1. Akiko Yamada, Aya Ushio, Rieko Arakaki, Takaaki Tsunematsu, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru :
Impaired expansion of regulatory T cells in a neonatal thymectomy-induced autoimmune mouse model.,
The American Journal of Pathology, Vol.185, No.11, 2886-2897, 2015.
(Tokushima University Institutional Repository: 113529,   DOI: 10.1016/j.ajpath.2015.07.007,   PubMed: 26343329)
2. Akihiko Iwasa, Rieko Arakaki, Naoko Honma, Aya Ushio, Akiko Yamada, Tomoyuki Kondo, Emi Kurosawa, Satoko Kujiraoka, Takaaki Tsunematsu, Yasusei Kudo, Eiji Tanaka, Noriko Yoshimura, Nobuhiro Harada, Yoshio Hayashi and Naozumi Ishimaru :
Aromatase controls Sjögren syndrome-like lesions through monocyte chemotactic protein-1 in target organ and adipose tissue-associated macrophages.,
The American Journal of Pathology, Vol.185, No.1, 151-161, 2015.
(Tokushima University Institutional Repository: 113532,   DOI: 10.1016/j.ajpath.2014.09.006,   PubMed: 25447050,   Elsevier: Scopus)
3. Rieko Arakaki, Hiroshi Eguchi, Akiko Yamada, Yasusei Kudo, Akihiko Iwasa, Enkhmaa Tserennadmid, Hotta Fumika, Mitamura-Aizawa Sayaka, Yoshio Hayashi and Naozumi Ishimaru :
Anti-Inflammatory Effects of Rebamipide Eyedrop Administration on Ocular Lesions in a Murine Model of Primary Sjögren's Syndrome.,
PLoS ONE, Vol.9, No.5, e98390, 2014.
(Tokushima University Institutional Repository: 110973,   DOI: 10.1371/journal.pone.0098390,   PubMed: 24866156,   Elsevier: Scopus)
4. Ashrin Nur Meinar, Rieko Arakaki, Akiko Yamada, Tomoyuki Kondo, Mie Kurosawa, Yasusei Kudo, Megumi Watanabe, Tetsuo Ichikawa, Yoshio Hayashi and Naozumi Ishimaru :
A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice.,
The Journal of Immunology, Vol.192, No.9, 4025-4031, 2014.
(DOI: 10.4049/jimmunol.1300276,   PubMed: 24670797,   Elsevier: Scopus)
5. Yosuke Shikama, Naozumi Ishimaru, Yasusei Kudo, Yukiko Bandou, N Aki, Yoshio Hayashi and Makoto Funaki :
Effects of Free Fatty Acids on Human Salivary Gland Epithelial Cells.,
Journal of Dental Research, Vol.92, No.6, 540-546, 2013.
(DOI: 10.1177/0022034513487378,   PubMed: 23603335)
6. Ritsuko 徳永 律子 Oura, Rieko Arakaki, Akiko Yamada, Yasusei Kudo, Eiji Tanaka, Yoshio Hayashi and Naozumi Ishimaru :
Induction of Rapid T Cell Death and Phagocytic Activity by Fas-Deficient lpr Macrophages.,
The Journal of Immunology, 2013.
(DOI: 10.4049/jimmunol.1103794,   PubMed: 23255359)
7. Takashi Izawa, Tomoyuki Kondo, Mie Kurosawa, Ritsuko 徳永 律子 Oura, Kazuma Matsumoto, Eiji Tanaka, Akiko Yamada, Rieko Arakaki, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru :
Fas-Independent T-Cell Apoptosis by Dendritic Cells Controls Autoimmune Arthritis in MRL/lpr Mice,
PLoS ONE, Vol.7, No.12, e48798, 2012.
(Tokushima University Institutional Repository: 110974,   DOI: 10.1371/journal.pone.0048798,   PubMed: 23300516)
8. Naozumi Ishimaru, Akiko Yamada, Takeshi Nitta, Rieko Arakaki, Martin Lipp, Yousuke Takahama and Yoshio Hayashi :
CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy.,
The American Journal of Pathology, Vol.180, No.1, 199-208, 2012.
(DOI: 10.1016/j.ajpath.2011.09.027,   PubMed: 22067914)
9. Megumi Watanabe, Naozumi Ishimaru, Meinar Nur Ashrin, Rieko Arakaki, Akiko Yamada, Tetsuo Ichikawa and Yoshio Hayashi :
A Novel DC Therapy with Manipulation of MKK6 Gene on Nickel Allergy in Mice,
PLoS ONE, Vol.6, No.4, E19017, 2011.
(DOI: 10.1371/journal.pone.0019017,   PubMed: 21544193)
10. Yu Lei, Adiratna Mat Ripen, Naozumi Ishimaru, Izumi Ohigashi, Takashi Nagasawa, Lukas T. Jeker, Michael R. Bösl, Georg A. Holländer, Yoshio Hayashi, Rene Waal de Malefyt, Takeshi Nitta and Yousuke Takahama :
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development,
The Journal of Experimental Medicine, Vol.208, No.2, 383-394, 2011.
(DOI: 10.1084/jem.20102327,   PubMed: 21300913)
11. Emi Kawakami, Nao Kinouchi, Taro Adachi, Yutaka Ohsawa, Naozumi Ishimaru, Hideyo Ohuchi, Yoshihide Sunada, Yoshio Hayashi, Eiji Tanaka and Sumihare Noji :
Atelocollagen-mediated systemic administration of myostatin-targeting siRNA improves muscular atrophy in caveolin-3-deficient mice.,
Development Growth & Differentiation, Vol.53, No.1, 48-54, 2011.
(DOI: 10.1111/j.1440-169X.2010.01221.x,   PubMed: 21261610)
12. Taro Adachi, Emi Kawakami, Naozumi Ishimaru, Takahiro Ochiya, Yoshio Hayashi, Hideyo Ohuchi, Masao Tanihara, Eiji Tanaka and Sumihare Noji :
Delivery of small interfering RNA with a synthetic collagen poly(Pro-Hyp-Gly) for gene silencing in vitro and in vivo.,
Development Growth & Differentiation, Vol.52, No.8, 693-699, 2010.
(DOI: 10.1111/j.1440-169X.2010.01206.x,   PubMed: 20874713)
13. Takashi Sakai, Li Liu, Xichuan Teng, Naozumi Ishimaru, Rika Mukai-Sakai, HoangNam Tran, Sun Mi Kim, Nobuya Sano, Yoshio Hayashi, Ryuji Kaji and Kiyoshi Fukui :
Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-knockout mice.,
International Journal of Cancer, Vol.126, No.5, 1079-1094, 2010.
(DOI: 10.1002/ijc.24789,   PubMed: 19637241,   Elsevier: Scopus)
14. Seiko Tatehara, Kenji Fujisawa, Hirokazu Nagai, Shuji Shigemoto, Kazuo Okura, Naozumi Ishimaru, Yoshio Hayashi and Youji Miyamoto :
切除からインプラントを維持源としたエピテーゼまで一貫治療を行った上顎洞悪性線維性組織球腫の1例,
Shikoku Dental Research, Vol.22, No.2, 179-183, 2010.
(Tokushima University Institutional Repository: 109796)
15. Naozumi Ishimaru, 小橋 真之, Akiko Yamada, Rieko Arakaki and Yoshio Hayashi :
新生児におけるダイオキシンへの曝露と自己免疫病の発生,
Clinical Immunology & Allergology, Vol.53, No.1, 92-96, 2010.
(CiNii: 40016992928)
16. Naozumi Ishimaru, Takeshi Nitta, Rieko Arakaki, Akiko Yamada, Martin Lipp, Yousuke Takahama and Yoshio Hayashi :
In situ Patrolling of Regulatory T cells is Essential for Protecting Autoimmune Exocrinopathy,
PLoS ONE, Vol.5, No.1, e8588, 2010.
(DOI: 10.1371/journal.pone.0008588,   PubMed: 20052419)
17. Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki, Nobuhiko Katsunuma and Yoshio Hayashi :
Cathepsin L inhivition prevents murine autoimmune diabetes via suppression of CD8+ T cell activity.,
PLoS ONE, Vol.5, No.9, e12894, 2010.
(DOI: 10.1371/journal.pone.0012894,   PubMed: 20877570)
18. Yoshio Hayashi, Rieko Arakaki and Naozumi Ishimaru :
Salivary gland and autoimmunity,
The Journal of Medical Investigation : JMI, Vol.56, 185-191, 2009.
(Tokushima University Institutional Repository: 111327,   DOI: 10.2152/jmi.56.185,   PubMed: 20224179)
19. Yoshio Hayashi, Naozumi Ishimaru and Rieko Arakaki :
シェーグレン症候群,
感染・炎症・免疫, Vol.39, No.3, 252-254, 2009.
20. Naozumi Ishimaru and Yoshio Hayashi :
Sjögren症候群の発症とエストロゲン,
Clinical Immunology, Vol.52, No.4, 431-437, 2009.
21. Kimi Yamakoshi, Akiko Takahashi, Fumiko Hirota, Rika Nakayama, Naozumi Ishimaru, Yoshiaki Kubo, J. David Mann, Masako Ohmura, Atsushi Hirao, Hideyuki Saya, Seiji Arase, Yoshio Hayashi, Kazuki Nakao, Mitsuru Matsumoto, Naoko Ohtani and Eiji Hara :
Real-time in vivo imaging of p16Ink4a reveals cross-talk with p53,
The Journal of Cell Biology, Vol.186, No.3, 393-407, 2009.
(DOI: 10.1083/jcb.200904105,   PubMed: 19667129)
22. Takeo Iwata, Masamichi Kuwajima, Akiko Sukeno, Naozumi Ishimaru, Yoshio Hayashi, Martin Wabitsch, Noriko Mizusawa, Mitsuo Itakura and Katsuhiko Yoshimoto :
YKL-40 secreted from adipose tissue inhibits degradation of type I collagen.,
Biochemical and Biophysical Research Communications, Vol.388, No.3, 511-516, 2009.
(Tokushima University Institutional Repository: 109641,   DOI: 10.1016/j.bbrc.2009.08.024,   PubMed: 19666003)
23. Naozumi Ishimaru, Takagi Atuya, Kohashi Masayuki, Akiko Yamada, Rieko Arakaki, Kanno Jun and Yoshio Hayashi :
Neonatal Exposure to Loe-Dose 2.3.7.8-Tetrachlorodibenzo-p-Dioxin Causes Autoimmunity Due to the Disruption of TCell Tolerance1,
The Journal of Immunology, Vol.182, No.10, 6576-6586, 2009.
(DOI: 10.4049/jimmunol.0802289,   PubMed: 19414813)
24. Rieko Arakaki, Ai Nagaoka, Naozumi Ishimaru, Akiko Yamada, Y Satoko and Yoshio Hayashi :
Role of Plasmacytoid Dendric Cells for Aberrant Class Expression in Exocrine Glands from Estrogen-Deficient Mice of healthy Background,
The American Journal of Pathology, Vol.174, No.5, 1715-1724, 2009.
(DOI: 10.2353/ajpath.2009.080695,   PubMed: 19359524)
25. Yukihiro Momota, Kazuhito Satomura, Tetsuya Yuasa, Keiko Kudoh, Hideyuki Takano, Yoshio Hayashi and Youji Miyamoto :
著しい骨吸収を伴う歯性上顎洞炎の1例,
Shikoku Dental Research, Vol.21, No.2, 407-411, 2009.
26. Naozumi Ishimaru, Rieko Arakaki, Satoko Yoshida, Akiko Yamada, Sumihare Noji and Yoshio Hayashi :
Expression of the retinoblastoma protein RbAp48 in exocrine glands leads to Sjögren's syndrome-like autoimmune exocrinopathy.,
The Journal of Experimental Medicine, Vol.205, No.12, 2915-2927, 2008.
(DOI: 10.1084/jem.20080174,   PubMed: 19015307)
27. Yu Hikosaka, Takeshi Nitta, Izumi Ohigashi, Kouta Yano, Naozumi Ishimaru, Yoshio Hayashi, Mitsuru Matsumoto, Koichi Matsuo, Josef M Penninger, Hiroshi Takayanagi, Yoshifumi Yokota, Hisakata Yamada, Yasunobu Yoshikai, Jun-ichiro Inoue, Taishin Akiyama and Yousuke Takahama :
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.,
Immunity, Vol.29, No.3, 438-450, 2008.
(DOI: 10.1016/j.immuni.2008.06.018,   PubMed: 18799150)
28. 中野 誠一, 山本 元久, 嶽村 貞治, Naozumi Ishimaru, Katsushi Miyazaki, Koichi Tamura, 氷見 徹夫, Yoshio Hayashi and Noriaki Takeda :
Three Cases of Mikulicz's Disease as an IgG4-related Disease,
Practica Oto-Rhino-Laryngologica, Vol.101, No.8, 591-597, 2008.
(DOI: 10.5631/jibirin.101.591,   CiNii: 10021940832,   Elsevier: Scopus)
29. Nao Kinouchi, Yutaka Ohsawa, Naozumi Ishimaru, Hideyo Ohuchi, Y Sunada, Yoshio Hayashi, Yukiho Tanimoto, Keiji Moriyama and Sumihare Noji :
Atelocollagen-mediated local and systemic applications of myostatin-targeting siRNA increase skeletal muscle mass.,
Gene Therapy, Vol.15, No.15, 1126-1130, 2008.
(DOI: 10.1038/gt.2008.24,   PubMed: 18323791)
30. Naozumi Ishimaru, Akiko Yamada, Masayuki Kohashi, Rieko Arakaki, Tetsuyuki Takahashi, Keisuke Izumi and Yoshio Hayashi :
Development of Inflammatory Bowel Disease in Long-Evans Cinnamon Rats Based on CD4+CD25+Foxp3+ Regulatory T Cell Dysfunction,
The Journal of Immunology, Vol.180, No.10, 6997-7008, 2008.
(PubMed: 18453622)
31. Masayuki Kohashi, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
Effective Treatment With Oral Administration of Rebamipide in a Model of Sjogren's Syndrome,
Arthritis and Rheumatism, Vol.58, No.2, 389-400, 2008.
(DOI: 10.1002/art.23163,   PubMed: 18240266)
32. Okura Yuka, Shiari Reza, Hattori Yoshinobu, Matsuzawa Tohru, Miyazaki Yusei, Yoshio Hayashi and Kobayashi Ichiro :
Epitope mapping of anti-α-fodrin antibody in a case of early-onset multiple sclerosis,
Pediatrics International, Vol.50, No.1, 135-137, 2008.
(DOI: 10.1111/j.1442-200X.2007.02521.x,   PubMed: 18279226)
33. Kazuhito Satomura, Reiko Tokuyama, Tetsuya Yuasa, Y Yamasaki, Seiko Tatehara, Naozumi Ishimaru, Yoshio Hayashi and Masaru Nagayama :
Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa.,
Journal of Oral Pathology & Medicine, Vol.36, No.10, 621-624, 2007.
(DOI: 10.1111/j.1600-0714.2007.00587.x,   PubMed: 17944756)
34. Naoko Ohtani, Yuko Imamura, Kimi Yamakoshi, Fumiko Hirota, Rika Nakayama, Yoshiaki Kubo, Naozumi Ishimaru, Akiko Takahashi, Atsushi Hirao, Takatsune Shimizu, David J. Mann, Hideyuki Saya, Yoshio Hayashi, Seiji Arase, Mitsuru Matsumoto, Nakao Kazuki and Eiji Hara :
Visualizing the dynamics of p21 (Wafl/Cip1)cyclin-dependent kinase inhibitor expression in living animals.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.104, No.38, 15034-15039, 2007.
(DOI: 10.1073/pnas.0706949104,   PubMed: 17848507)
35. Takashi Izawa, Naozumi Ishimaru, Keiji Moriyama, Masayuki Kohashi, Rieko Arakaki and Yoshio Hayashi :
Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance,
Blood, Vol.110, No.1, 242-250, 2007.
(DOI: 10.1182/blood-2006-11-059980,   PubMed: 17371940)
36. Naozumi Ishimaru, Hidehiro Kishimoto, Yoshio Hayashi and Jonathan Sprent :
Regulation of naive T cell function by the NF-κB2 pathway,
Nature Immunology, Vol.7, No.7, 763-772, 2006.
(DOI: 10.1038/ni1351,   PubMed: 16732290)
37. Nobuhiko Katunuma, Quang Trong Le, Etsuko Murata, Atsushi Matsui, Eiji Majima, Naozumi Ishimaru, Yoshio Hayashi and Atsushi Ohashi :
A novel apoptosis cascade mediated by lysosomal lactoferrin and its participation in hepatocyte apoptosis induced by D-galactosamine.,
FEBS Letters, Vol.580, No.15, 3699-3705, 2006.
(DOI: 10.1016/j.febslet.2006.05.057,   PubMed: 16765951)
38. Masayuki Azuma, Yuki Ashida, Tetsuya Tamatani, Katsumi Motegi, Natsumi Takamaru, Naozumi Ishimaru, Yoshio Hayashi and Mitsunobu Sato :
Cepharanthin,a biscoclaurine alkaloid,prevents destruction of acinar tissues in murine Sjogren's syndrome.,
The Journal of Rheumatology, Vol.33, No.5, 912-920, 2006.
(PubMed: 16652422)
39. Naoto Suzue, Takeshi Nikawa, Yuko Onishi, Chiharu Yamada, Katsuya Hirasaka, Takayuki Ogawa, Harumi Furochi, Hirofumi Kosaka, Kazumi Ishidoh, Gu Hua, Shin'ichi Takeda, Naozumi Ishimaru, Yoshio Hayashi, Hironori Yamamoto, Kyoichi Kishi and Natsuo Yasui :
Ubiqitin Ligase Cbl-b Downregulates Bone Formation Through Suppression of IGF-I Signaling in Osteoblasts During Denervation,
Journal of Bone and Mineral Research, Vol.21, No.5, 722-734, 2006.
(DOI: 10.1359/jbmr.060207,   PubMed: 16734387,   Elsevier: Scopus)
40. Naozumi Ishimaru, Rieko Arakaki, Fumie Omotehara, Kouichi Yamada, Kenji Mishima, Ichiro Saito and Yoshio Hayashi :
Novel role for RbAp48 in tissue-specific,estrogen deficiency-dependent apoptosis in the exocrine glands.,
Molecular and Cellular Biology, Vol.26, No.8, 2924-2935, 2006.
(DOI: 10.1128/MCB.26.8.2924-2935.2006,   PubMed: 16581768)
41. Naozumi Ishimaru and Yoshio Hayashi :
Crucial Roles of NF-kB for T Cell Activation,
Journal of Oral Biosciences, Vol.48, No.1, 12-17, 2006.
(DOI: 10.2330/joralbiosci.48.12,   CiNii: 10017280299)
42. Nobuhiko Katumuma, Atsushi Ohashi, Etsuko Sano, Naozumi Ishimaru, Yoshio Hayashi and Etsuko Murata :
Catechin derivatives:specific inhibitor for caspases-3,7and 2,and the prevention of apoptosis at the cell and animal levels.,
FEBS Letters, Vol.580, No.3, 741-746, 2006.
(DOI: 10.1016/j.febslet.2005.12.087,   PubMed: 16413020)
43. Hirotsugu Kurobe, Cunian Liu, Tomoo Ueno, Fumi Saito, Izumni Ohigashi, Natalle Seach, Rieko Arakaki, Yoshio Hayashi, Tetsuya Kitagawa, Martin Lipp, Richard L. Boyd and Yousuke Takahama :
CCR7-Dependent Cortex-to-Medulla Migration of Positively Selected Thymocytes Is Essential for Establishing Central Tolerance,
Immunity, Vol.24, No.2, 165-177, 2006.
(DOI: 10.1016/j.immuni.2005.12.011,   PubMed: 16473829)
44. Kumi Obara, Fumio Ide, Kenji Mishima, Hiroko Inoue, Hiroyuki Yamada, Yoshio Hayashi and Ichiro Saito :
Biological and oncogenic properties of p53-deficient salivary gland epithelial cells with particular emphasis on stromal-epithelial interactions in tumorigenesis.,
Pathobiology, Vol.73, No.5, 261-270, 2006.
(DOI: 10.1159/000098212,   PubMed: 17314497,   Elsevier: Scopus)
45. Katsushi Miyazaki, Noriaki Takeda, Naozumi Ishimaru, Fumie Omotehara, Rieko Arakaki and Yoshio Hayashi :
Analysis of in vivo role of alpha-fodrin autoantigen in primary Sjogren's syndrome,
The American Journal of Pathology, Vol.167, No.4, 1051-1059, 2005.
(DOI: 10.1016/S0002-9440(10)61194-7,   PubMed: 16192640)
46. Noriyuki Kuroda, Tasuku Mitani, Naoki Takeda, Naozumi Ishimaru, Rieko Arakaki, Yoshio Hayashi, Yoshimi Bando, Keisuke Izumi, Takeshi Takahashi, Takashi Nomura, Shimon Sakaguchi, Tomoo Ueno, Yousuke Takahama, Daisuke Uchida, Shijie Sun, Fumiko Kajiura, Yasuhiro Mouri, Hongwei Han, Akemi Matsushima, Gen Yamada and Mitsuru Matsumoto :
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice,
The Journal of Immunology, Vol.174, No.4, 1862-1870, 2005.
(DOI: 10.3410/f.1024264.287833,   PubMed: 15699112)
47. Miriam Entesarian, Hans Matsson, Joakim Klar, Birgitta Bergendal, Lena Olson, Rieko Arakaki, Yoshio Hayashi, Hideyo Ohuchi, Babak Falahat, Isinev Anne Bolstad, Roland Jonsson, Marie Wahren-Herlenius and Niklas Dahl :
Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands,
Nature Genetics, Vol.37, No.2, 125-127, 2005.
(DOI: 10.1038/ng1507,   PubMed: 15654336)
48. Masaru Kobayashi, Natsuo Yasui, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
Development of Autoimmune Arthritis With Aging Via Bystander T Cell Activation in the Mouse Model of Sjogren's Syndrome,
Arthritis and Rheumatism, Vol.50, No.12, 3974-3984, 2004.
(DOI: 10.1002/art.20679,   PubMed: 15593201)
49. Yuki Hayashi, Naozumi Ishimaru, Rieko Arakaki, Shin-ichi Tsukumo, Hitomi Fukui, Kenji Kishihara, Hiroshi Shiota, Koji Yasutomo and Yoshio Hayashi :
Effective Treatment of a Mouse Model of Sjogren's Syndrome With Eyedrop Administrasiton of Anti-CD4 Monoclonal Antibody,
Arthritis and Rheumatism, Vol.50, No.9, 2903-2910, 2004.
(DOI: 10.1002/art.20472,   PubMed: 15457459)
50. Nobuhiko Katumuma, Etsuko Murata, T Quang Le, Yoshio Hayashi and Atsushi Ohashi :
Newapoptosis cascade mediated by lysosomal enzyme and its protection by epigallo-catechin gallate,
Advances in Enzyme Regulation, Vol.44, No.1, 1-10, 2004.
(DOI: 10.1016/j.advenzreg.2003.11.016,   PubMed: 15581478)
51. Toshiaki Maruyama, Ichiro Saito, Yoshio Hayashi, Elizabeth Kompfner, Robert I. Fox, Dennis R. Burton and Henrik J. Ditzel :
Molecular Analysis of the Human Autoantibody Response to α-Fodrin in Sjogren Syndrome Reveals Novel Apoptosis-Induced Specificity,
The American Journal of Pathology, Vol.165, No.1, 53-61, 2004.
(DOI: 10.1016/S0002-9440(10)63274-9,   PubMed: 15215161)
52. Tomoko Yoneda, Naozumi Ishimaru, Rieko Arakaki, Masaru Kobayashi, Takashi Izawa, Keiji Moriyama and Yoshio Hayashi :
Estrogen deficiency accelerates murine autoimmune arthritis associated with receptor activator of nuclear factor-kappaB ligand-mediated osteoclastogenesis,
Endocrinology, Vol.145, No.5, 2384-2391, 2004.
(DOI: 10.1210/en.2003-1536,   PubMed: 14726437)
53. Hideko Endo, Mitsuyoshi Hirokawa, Naozumi Ishimaru, Yasushi Tanaka, Michiko Yamashita, Mika Sakaki, Yoshio Hayashi and Toshiaki Sano :
Unique cell membrane expression if topoisomerase-ll alpha as a useful diagnostic marker of liposarcoma,
Pathology International, Vol.54, No.3, 145-150, 2004.
(DOI: 10.1111/j.1440-1827.2003.01600.x,   PubMed: 14989736)
54. Naozumi Ishimaru, Rieko Arakaki, Nobuhiko Katunuma and Yoshio Hayashi :
Critical Role of Cathepsin-Inhibitors for Autoantigen Processing and Autoimmunity,
Advances in Enzyme Regulation, Vol.44, No.1, 309-320, 2004.
(DOI: 10.1016/j.advenzreg.2003.11.004,   PubMed: 15581498)
55. Yukihiro Momota, Nobuyuki Kamata, Keiko Kume, Seiko Tatehara, Yoshio Hayashi and Masaru Nagayama :
Two Cases of So-Called Kuttner Tumor of Submandibular Gland,
Shikoku Dental Research, Vol.16, No.2, 419-423, 2004.
56. Keiko Kudoh, 鎌田 伸之, Masaaki Takechi, 山之内 浩司, Yoshio Hayashi and Masaru Nagayama :
A Case of Quadruple Cancer Arising Synchronously in the Qpper Gingiva,Penis,and Kidney 2 Years After Colon Cancer Treatment,
Japanese Journal of Oral & Maxillofacial Surgery, Vol.50, No.8, 503-506, 2004.
(DOI: 10.5794/jjoms.50.503)
57. Rieko Arakaki, Naozumi Ishimaru, Ichiro Saito, Masaru Kobayashi, Natsuo Yasui, Takayuki Sumida and Yoshio Hayashi :
Development of Autoimmune Exocrinopathy Resembling Sjogren's Syndrome in Adoptively Transferred Mice With Autoreactive CD4+ T Cells,
Arthritis and Rheumatism, Vol.48, No.12, 3603-3609, 2003.
(DOI: 10.1002/art.11352,   PubMed: 14674013)
58. Kouichi Ogawa, Shinji Nagahiro, Rieko Arakaki, Naozumi Ishimaru, Masaru Kobayashi and Yoshio Hayashi :
Anti-a-fodrin autoantibodies in Moyamoya disease,
Stroke, Vol.34, No.12, 244-246, 2003.
(DOI: 10.1161/01.STR.0000100479.63243.48,   PubMed: 14657555)
59. Naozumi Ishimaru, Rieko Arakaki, Megumi Watanabe, Kobayashi Masaru, Katsushi Miyazaki and Yoshio Hayashi :
Development of autoimmune exocrinopathy resembling Sjogren's syndorome in estorogen deficient mice of healthy background,
The American Journal of Pathology, Vol.163, No.4, 1481-1490, 2003.
(DOI: 10.1016/S0002-9440(10)63505-5,   PubMed: 14507655)
60. Eiichiro Kitaoka, Nobuyuki Kamata, 山之内 浩司, Kenji Fujisawa, Yoshio Hayashi and Masaru Nagayama :
顎関節に発生した滑膜性軟骨腫症の1例,
Japanese Journal of Oral & Maxillofacial Surgery, Vol.49, No.8, 513-516, 2003.
(DOI: 10.5794/jjoms.49.513,   CiNii: 10012629828)
61. Nobuhiko Katunuma, Yoishi Matsunaga, Kunisuke Himeno and Yoshio Hayashi :
Insights into the roles of cathepsins in antigen processing and presentation revealed by specific inhibitors,
Biological Chemistry, Vol.384, No.6, 883-890, 2003.
(DOI: 10.1515/BC.2003.099,   PubMed: 12887055)
62. Yoshifumi Nagata, Hiroko Inoue, Koichi Yamada, Hiroyuki Higashiyama, Kenji Mishima, Yasuhiro Kizu, Ienaka Takeda, Fumio Mizuno, Yoshio Hayashi and Ichiro Saito :
Activation of Epstein-Barr virus by saliva from Sjogren's syndrome patients,
Immunology, Vol.111, No.2, 223-229, 2003.
(DOI: 10.1111/j.0019-2805.2003.01795.x,   PubMed: 15027908)
63. Nobuyuki Kamata, Eiichiro Kitaoka, 山之内 浩司, Yukihiro Momota, Yoshio Hayashi and Masaru Nagayama :
6歳児の下顎骨に発生した若年性(侵襲性)化骨性線維腫の1例,
Pediatric Oral and Maxillofacial Surgery, Vol.12, No.2, 25-28, 2002.
(CiNii: 50000725030)
64. Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Rieko Arakaki, Kouichi Ogawa, Ichiro Saito, Nobuhiko Katunuma and Yoshio Hayashi :
Cathepsin S-inhibitor prevents autoantigen presentation and autoimmunity,
The Journal of Clinical Investigation, Vol.110, No.3, 361-369, 2002.
(DOI: 10.1172/JCI14682,   PubMed: 12163455)
65. Kenji Mishima, Kazuya Inoue and Yoshio Hayashi :
Overexpression of extracelular-signal regulated kinases on oral squamous cell carcinoma,
Oral Oncology, Vol.38, No.5, 468-474, 2002.
(PubMed: 12110341)
66. Masayuki Azuma, Keiko Aota, Tetsuya Tamatani, Katsumi Motegi, Yuki Ashida, Yoshio Hayashi, Mitsunobu Sato and Mitsunobu Sato :
Suppression of TNF-α-induced MMP 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of NFκB, --- A possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjögren's syndrome patients ---,
Arthritis and Rheumatism, Vol.46, No.6, 1585-1594, 2002.
(DOI: 10.1002/art.10315,   PubMed: 12115190)
67. Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Kenji Mishima, Rieko Arakaki, Takashi Suda, Ichiro Saito and Yoshio Hayashi :
Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjogren's syndrome,
The Journal of Immunology, Vol.169, No.2, 1050-1057, 2002.
(PubMed: 12097413,   CiNii: 80015444001)
68. Naozumi Ishimaru, Kumiko Yanagi, Kouichi Ogawa, Takashi Suda, Ichiro Saito and Yoshio Hayashi :
Possible Role of Organ-Specific Autoantigen for Fas Ligand-Mediated Activation-Induced Cell Death in Murine Sjögren's Syndrome1,
The Journal of Immunology, Vol.167, No.10, 6031-6037, 2001.
(DOI: 10.4049/jimmunol.167.10.6031,   PubMed: 11698484,   Elsevier: Scopus)
69. Hiroko Inoue, Kazuo Tsubota, Masafumi Ono, Yasuhiro Kizu, Fumio Mizuno, Kenzo Takada, Koichi Yamada, Kumiko Yanagi, Yoshio Hayashi and Ichiro Saito :
Possible Involvement of EBV-Mediated α-Fodrin Cleavage for Organ-Specific Autoantigen in Sjogren's Syndrome,
The Journal of Immunology, Vol.166, No.9, 5801-5809, 2001.
(PubMed: 11313424,   Elsevier: Scopus)
70. Nobuaki Maeno, Syuji Takei, Hiroyuki Imanaka, Hiroshi Oda, Yoshio Hayashi and Koichiro Miyata :
Anti-alpha-fodrin antibodies in Sjogren's syndrome in children,
The Journal of Rheumatology, Vol.28, No.4, 860-864, 2001.
(PubMed: 11327263)
71. Ichiro Kobayashi, Nobuaki Kawamura, Motohiko Okano, Takaaki Shikano, Masahiko Mizutomo, Yoshio Hayashi and Kunihiko Kobayashi :
Anti-α-Fordrin Autoantibody Is an Early Diagnostic Marker for Childhood Primary Shogren Syndrome,
The Journal of Rheumatology, Vol.28, No.2, 363-365, 2001.
(PubMed: 11246678,   Elsevier: Scopus)
72. Kazuo Tsubota, Hiromi Fujita, Kimie Tadano, Tsutomu Takeuchi, Tadahiro Murakami, Ichiro Saito and Yoshio Hayashi :
Improvement of Lacrimal Function by Topical Application of CyA in Murine Models of Sjögren's Syndrome,
Investigative Ophthalmology & Visual Science, Vol.42, No.1, 101-110, 2001.
(PubMed: 11133854)
73. Kaoru Saegusa, Naozumi Ishimaru, Norio Haneji, Kumiko Yanagi, Tomoko Yoneda, Ichiro Saito and Yoshio Hayashi :
Mechanisms of neonatal tolerance induced in an animal model for primary Sjogren's syndrome by intravenous administration of autoantigen,
Scandinavian Journal of Immunology, Vol.52, No.3, 264-270, 2000.
(DOI: 10.1046/j.1365-3083.2000.00777.x,   PubMed: 10972902,   Elsevier: Scopus)
74. Hideaki Nakamura, Atsushi Kawakami, Satoshi Yamasaki, Tomoki Nakashima, Makoto Kamachi, Kiyoshi Migita, Yojiro Kawabe, Tatsufumi Nakamura, Takehiko Koji, Yoshio Hayashi and Katsumi Eguchi :
Expression and Function of X Chromosome-Linked Inhibitor of Apoptosis Protein in Sjogren's Syndrome,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.80, No.9, 1421-1427, 2000.
(PubMed: 11005210,   Elsevier: Scopus)
75. Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Norio Haneji, Mizuho Nishino, Masayuki Azuma, Ichiro Saito and Yoshio Hayashi :
Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjogren's syndrome,
The Journal of Immunology, Vol.165, No.4, 2251-2257, 2000.
(DOI: 10.4049/jimmunol.165.4.2251,   PubMed: 10925313,   Elsevier: Scopus)
76. Masayuki Azuma, Tetsuya Tamatani, Katsumi Motegi, Keiko Aota, Tsuyoshi Yamashita, Kouji Harada, Yoshio Hayashi and Mitsunobu Sato :
Suppression of tumor necrosis factor-a-induced matrix metalloproteinase-9-production by introduction of a super-repressor form of IkB-cDNA into immotalized human salivary gland acinar cells,
Arthritis and Rheumatism, Vol.43, No.8, 1756-1767, 2000.
(DOI: 10.1002/1529-0131(200008)43:8<1756::AID-ANR12>3.0.CO;2-H,   PubMed: 10943866,   Elsevier: Scopus)
77. Keiko Aota, Masayuki Azuma, Tsuyoshi Yamashita, Testuya Tamatani, Katsumi Motegi, Naozumi Ishimaru, Yoshio Hayashi and Mitsunobu Sato :
5-Fluorouracil Induces Apoptosis through the Suppression of NF-κB Activity in Human Salivary Gland Cancer Cells,
Biochemical and Biophysical Research Communications, Vol.273, No.3, 1168-1174, 2000.
(DOI: 10.1006/bbrc.2000.3072,   PubMed: 10891390)
78. Maki Kondo, Takashi Yamaoka, Soichi Honda, Yoshihiro Miwa, Maki Moritani, Kastuhiko Yoshimoto, Yoshio Hayashi and Mitsuo Itakura :
The Rate of Cell Growth Is Regulated by Purine Biosynthesis via ATP Production and G to Sphase Transition,
The Journal of Biochemistry, Vol.128, No.1, 57-64, 2000.
(PubMed: 10876158,   Elsevier: Scopus)
79. Naozumi Ishimaru, Tomoko Yoneda, Kaoru Saegusa, Kumiko Yanagi, Norio Haneji, Keiji Moriyama, Ichiro Saito and Yoshio Hayashi :
Severe destructive autoimmune lesions with aging in murine Sjogren's syndrome through Fas-mediated apoptosis,
The American Journal of Pathology, Vol.156, No.5, 1557-1564, 2000.
(DOI: 10.1016/S0002-9440(10)65027-4,   PubMed: 10793067,   Elsevier: Scopus)
80. Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Norio Haneji, Mizuho Nishino, Masayuki Azuma and Yoshio Hayashi :
Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome (SS) through up-regulated Th2 response,
Clinical and Experimental Immunology, Vol.119, No.2, 354-360, 2000.
81. Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagai, Norio Haneji, Mizuho Nishino, Masayuki Azuma, Ichiro Saito and Yoshio Hayashi :
Treatment with anti-CD 86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome(SS) through up-regulated Th2 response,
Clinical and Experimental Immunology, Vol.119, 354-360, 2000.
82. Maki Kondo, Takashi Yamaoka, Soichi Honda, Yoshihiro Miwa, Rumi Katashima, Maki Moritani, Katsuhiko Yoshimoto, Yoshio Hayashi and Mitsuo Itakura :
The Rate of Cell Growth is Regulated by Purine Biosynthesis via ATP Production and G1 to S Phase Transition.,
The Journal of Biochemistry, Vol.128, No.1, 57-64, 2000.
83. Naozumi Ishimaru, 羽地 則雄, 柳 久美子 and Yoshio Hayashi :
Theraputic effect of fosfomycin in animal model of sjögren's syndrome,
Japanese Journal of Chemotherapy, Vol.48, 775-779, 2000.
(DOI: 10.11250/chemotherapy1995.48.775,   Elsevier: Scopus)
84. 柳 久美子, Masayuki Azuma, Mitsunobu Sato and Yoshio Hayashi :
慢性GVHDにおける口腔粘膜·口唇腺の免疫組織化学的研究,
日本口腔粘膜学会雑誌, Vol.6, 62-68, 2000.
85. Kouji Nitta, Eiji Hayashi, Kenji Fujisawa, Nobuyuki Kamata, Masaru Nagayama, Naozumi Ishimaru and Yoshio Hayashi :
Two cases of ameloblastic fibro-odontoma,
Japanese Journal of Oral & Maxillofacial Surgery, Vol.46, No.8, 481-483, 2000.
(DOI: 10.5794/jjoms.46.481)
86. Naozumi Ishimaru, Kaoru Saegusa, Kumiko Yanagi, Norio Haneji, Ichiro Saito and Yoshio Hayashi :
Estrogen Deficiency Accelerates Autoimmune Exocrinopathy in Murine Sjögren's Syndrome through Fas-Mediated Apoptosis,
The American Journal of Pathology, Vol.155, No.1, 173-181, 1999.
87. Naozumi Ishimaru, Kaoru Saegusa, Kumiko Yanagi, Norio Haneji, Ichiro Saito and Yoshio Hayashi :
Estrogen dediciency accelerates autoimmune exocrinopathy in murine Sjogren's syndrome through Fas-dediated apoptosis,
The American Journal of Pathology, Vol.155, No.1, 173-181, 1999.
(DOI: 10.1016/S0002-9440(10)65111-5,   PubMed: 10393849,   Elsevier: Scopus)
88. Mariko Takahashi, Naozumi Ishimaru, Kumiko Yanagi, Kaoru Saegusa, Norio Haneji, Hiroshi Shiota and Yoshio Hayashi :
Requirement for splenic CD4+ T cells in the immune privilege of the anterior chamber of the eye,
Clinical and Experimental Immunology, Vol.116, No.2, 231-237, 1999.
89. Takahiro Watanabe, Tetsuya Tsuchida, Naoko Kanda, Katsunori Mori and Yoshio Hayashi :
Anti-α-fodrin antibodies in Sjogren's syndrome and lupus erythematosus,
Arch Dermatol, Vol.135, No.5, 535-539, 1999.
90. Ichiro Saito, Kumiko Haruta, Misa Shimuta, Hiroko Inoue, Hiroshi Sakurai, Koichi Yamada, Naozumi Ishimaru, Hiroyuki Higashiyama, Takayuki Sumida, Hiroshi Ishida, Takashi Suda, Tetsuo Noda, Yoshio Hayashi and Kazuo Tsubota :
Fas ligand-mediated exocrinopathy resembling Sjogren's syndrome in mice transgenic for IL-10,
The Journal of Immunology, Vol.162, No.5, 2488-2492, 1999.
(PubMed: 10072487,   Elsevier: Scopus)
91. Sachiko Miyagawa, Kumiko Yanagi, Akira Yoshioka, Kin-ichi Kidoguchi, Toshihiko Shirai and Yoshio Hayashi :
Neonatal lupus erythematosus: Maternal IgG antibodies bind to a recombinant NH2-terminal fusion protein encoded by human α-fodrin cDNA,
The Journal of Investigative Dermatology, Vol.111, No.6, 1189-1192, 1998.
(DOI: 10.1046/j.1523-1747.1998.00440.x,   PubMed: 9856838)
92. Kazuo Tsubota, Ichiro Saito, Naozumi Ishimaru and Yoshio Hayashi :
Use of topical cyclosporin A in a primary Sjogren's syndrome mouse model,
Investigative Ophthalmology & Visual Science, Vol.39, No.9, 1551-1559, 1998.
(PubMed: 9699544)
93. Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Norio Haneji, Mizuho Nishino and Yoshio Hayashi :
Mechanisms of transfer into SCID mice reconstituted with tissue-infiltrating cells from murine model for Sjogren's syndrome,
Oral Med Pathol, Vol.3, 67-74, 1998.
94. Kumiko Yanagi, Naozumi Ishimaru, Norio Haneji, Kaoru Saegusa, Ichiro Saito and Yoshio Hayashi :
Anti-120-kDa a-fodrin immune response withTh-1-cytokine profile in the NOD mouse model of Sjogren's syndrome,
Eur. J. Immunol., Vol.28, 3336-3345, 1998.
95. Masayuki Azuma, Katsumi Motegi, Keiko Aota, Yoshio Hayashi and Mitsunobu Sato :
Role of cytokines in the destruction of acinar structure in Sjogren's syndrome salivary glands,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.77, No.3, 269-280, 1997.
96. Norio Haneji, Takanori Nakamura, Koji Takio, Kumiko Yanagi, Hiroyuki Higashiyama, Ichiro Saito, Sumihare Noji, Hiromu Sugino and Yoshio Hayashi :
Identification of α-fodrin as a candidate autoantigen in primary sjögren's syndrome,
Science, Vol.276, No.5312, 604-607, 1997.
(DOI: 10.1126/science.276.5312.604,   PubMed: 9110981)
97. Naozumi Ishimaru, Norio Haneji, Hironori Hamano, Kumiko Yanagi, Mariko Takahashi and Yoshio Hayashi :
Accelerated onset of age-related autoimmune lesions in MRL/+ mice by ovariectomy,
Mechanisms of Ageing and Development, Vol.93, No.1-3, 145-156, 1997.
98. Mariko Takahashi, Naozumi Ishimaru, Kumiko Yanagi, Norio Haneji, Ichiro Saito and Yoshio Hayashi :
High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid,
Clinical and Experimental Immunology, Vol.109, 555-561, 1997.
99. Masayuki Azuma, Katsumi Motegi, Keiko Aota, Yoshio Hayashi and Mitsunobu Sato :
Role of cytokines of acinar structure in Sjogren's syndrome salivary glands,
Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.77, No.3, 269-280, 1997.
100. Kumiko Yanagi, Norio Haneji, Naozumi Ishimaru, Ichiro Saito and Yoshio Hayashi :
Analysis of T cell receptor Vb usage in the autoimmune sialadenitis of non-obese diabetic (NOD) mice,
Clinical and Experimental Immunology, Vol.110, 440-446, 1997.
101. Yoshio Hayashi, Norio Haneji, Hironori Hamano, Kumiko Yanagi, Mariko Takahashi and Naozumi Ishimaru :
Effector Mechanism of Experimental Autoimmune Sialadenitis in the Mouse Model for Primary Sjogren's Syndrome,
Cellular Immunology, Vol.171, No.2, 217-225, 1996.
(DOI: 10.1006/cimm.1996.0196,   PubMed: 8806790)
102. Youji Miyamoto, Kenji Fujisawa, Masaru Nagayama, Norio Haneji and Yoshio Hayashi :
Carcinoma in Pleomorphic Adenoma of the Tongue ; Report of a case,
Oral Medicine & Pathology, Vol.1, No.2, 111-114, 1996.
(CiNii: 110002985130)
103. Mariko Takahashi, Yasuo Mimura, Hironori Hamano, Norio Haneji, Kumiko Yanagi and Yoshio Hayashi :
Mechanism of the development of autoimmune dacryoadenitis in the mouse model for primary Sjogren's syndrome,
Cellular Immunology, Vol.170, No.1, 54-62, 1996.
(DOI: 10.1006/cimm.1996.0133,   PubMed: 8660799)
104. Youji Miyamoto, Masaru Nagayama and Yoshio Hayashi :
Verruciform xanthoma occurring within oral lichen planus,
Journal of Oral Pathology & Medicine, Vol.25, No.4, 188-191, 1996.
105. Kumiko Yanagi, Norio Haneji, Hironori Hamano, Mariko Takahashi, Hiroyuki Higashiyama and Yoshio Hayashi :
In vivo role of IL-10 and IL-12 during development of Sjogren's syndrome in MRL/lpr mice,
Cellular Immunology, Vol.168, No.2, 243-250, 1996.
(DOI: 10.1006/cimm.1996.0072,   PubMed: 8640871)
106. Sachiko Iseki, Akihiro Araga, Hideyo Ohuchi, Tsutomu Nohno, Hidefumi Yoshioka, Yoshio Hayashi and Sumihare Noji :
Sonic hedgehog is expressed in epithelial cells during development of whiskar, hair, and tooth,
Biochemical and Biophysical Research Communications, Vol.218, No.3, 688-693, 1996.
107. Eiki Koyama, Tomoichiro Yamaai, Sachiko Iseki, Hideyo Ohuchi, Tsutomu Nohno, Hidefumi Yoshioka, Yoshio Hayashi, Judith L. Leatherman, Eleanor B. Golden, Sumihare Noji and Maurizio Pacifici :
Polarizing activity, Sonic headgehog, and tooth development in embryonic and postnatal mouse,
Developmental Dynamics, Vol.206, 59-72, 1996.
108. Yoshio Hayashi, Norio Haneji and Hironori Hamano :
Cytokine gene expression and autoantibody production in Sjogren's syndrome in MRL/lpr mice,
Autoimmunity, Vol.23, No.4, 269-277, 1996.
(PubMed: 8915033)
109. Kumiko Yanagi, Norio haneji, Naozumi Ishimaru, Hironori Hamano and Yoshio Hayashi :
Immunopathological analysis of mucosal melanocyte distribution in the human lower lip of the elderly,
Pathobiology, Vol.64, No.3, 156-160, 1996.
110. Mariko Takahashi, Yasuo Mimura and Yoshio Hayashi :
Role of the ICAM-1/LFA-1 pathway during development of autoimmune dacryoadenitis in an animal model for Sjogren's syndrome,
Pathobiology, Vol.64, No.5, 269-274, 1996.
(DOI: 10.1159/000164058,   PubMed: 9068010)
111. Hironori Hamano, Norio Haneji, Kumiko Yanagi, Naozumi Ishimaru and Yoshio Hayashi :
Expression of HLA-DR and cytokine genes on interferon-γ-stimulated human salivary gland cell line,
Pathobiology, Vol.64, No.5, 255-261, 1996.
(PubMed: 9068008)
112. Hiroyuki Higashiyama, Ichiro Saito, Yoshio Hayashi and Nobuyuki Miyasaka :
: In situ hybridization study of vascular cell adhesion molecule-1 messenger RNA expression in eheumatoid synovium,
Journal of Autoimmunity, Vol.8, No.6, 947-957, 1995.
(PubMed: 8824717)
113. Yoshio Hayashi, N Haneji, K Yanagi, H Higashiyama, H Yagita and H Hamano :
Prevention of adoptive transfer of murine Sjogren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1),
Clinical and Experimental Immunology, Vol.102, No.2, 360-367, 1995.
(PubMed: 7586691)
114. 中村 みちる, 谷口 信行, Yoshio Hayashi, 川井 夫規子, 入江 喬介 and 伊藤 紘一 :
小児顎下腺 エコ-レベルの年齢的変化,
Japanese Journal of Medical Ultrasonics, Vol.22, No.11, 17-22, 1995.
115. Hiroyuki Inoue, Hitoshi Miki, Kazushi Oshimo, Katuhiro Tanaka, Yasumasa Monden, Akihiro Yamamoto, Susumu Kagawa, Nobuya Sano, Eiji Hayashi, Masaru Nagayama and Yoshio Hayashi :
Familial hyperparathyroidism associated with jaw fibroma: case report and literature review,
Clinical Endocrinology, Vol.43, No.2, 225-229, 1995.
(DOI: 10.1111/j.1365-2265.1995.tb01919.x,   PubMed: 7554319)
116. Sachiko Iseki, Noriko Osumi-Yamashita, Kohei Miyazono, Peter Franzen, Hidenori Ichijo, Haruo Ohtani, Yoshio Hayashi and Kazuhiro Eto :
Localization of transforming growth factor-β type I and type II receptors in mouse development,
Experimental Cell Research, Vol.219, No.2, 339-347, 1995.
117. Yoshio Hayashi and 羽地 則雄 :
シェーグレン症候群疾患モデルのSCIDマウスへの移入,
Japanese Journal of Inflammation, Vol.15, No.3, 225-230, 1995.
118. Yoshio Hayashi and 羽地 則雄 :
NFS/sldミュータントマウスにおけるシェーグレン症候群疾患モデルの確立,
Clinical Immunology, Vol.27, No.4, 488-492, 1995.
119. Youji Miyamoto, Kazuhito Satomura, Koichi Rikimaru and Yoshio Hayashi :
Desmoplastic fibroma of the mandible associated with tuberous sclerosis,
Journal of Oral Pathology & Medicine, Vol.24, No.2, 93-96, 1995.
120. Yoshio Hayashi, Hironori Hamano, Norio Haneji, Naozumi Ishimaru and Kumiko Yanagi :
Biased T cell receptor Vβ gene usage during specific stages of the development of autoimmune sialadenitis in the MRL/lpr mouse model of Sjogren's syndrome,
Arthritis &Rheumatism, Vol.38, No.8, 1077-1084, 1995.
121. Norio Haneji, Hironori Hamano, Kumiko Yanagi and Yoshio Hayashi :
A new animal model for primary Sjogren's syndrome in NFS/sld mutant mice,
The Journal of Immunology, Vol.153, No.6, 2796-2777, 1994.
122. Chieri Kurashima, Masanori Utsuyama, Yoshio Hayashi and Katsuiku Hirokawa :
Epithelial class II MHC antigen normally expressed by submandibular glands of elderly people,
Pathobiology, Vol.62, No.5-6, 292-297, 1994.
123. Maki Moritani, Katsuhiko Yoshimoto, Fumi Tashiro, Chikara Hashimoto, Jun-ichi Miyazaki, Setsuko Ii, Eiji Kudo, Hiroyuki Iwahana, Yoshio Hayashi, Toshiaki Sano and Mitsuo Itakura :
Transgenic Expression of IL-10 in Pancreatic Islet A cells Accelerates Autoimmune Insulitis and Diabetes in Non-Obese Diabetic Mice.,
International Immunology, Vol.6, No.12, 1927-1936, 1994.
124. Yoshio Hayashi, Norio Haneji, Hironori Hamano and Kumiko Yanagi :
Transfer of Sjogren's syndrome-like autpoimmune lesions into SCID mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment,
Eur. J. Immunol, Vol.24, 2826-2831, 1994.
125. 出口 博代, 浜野 弘規 and Yoshio Hayashi :
唾液腺多形性腺腫における各種癌遺伝子産物の発現,
Journal of The Japanese Stomatological Society, Vol.42, No.4, 729-734, 1993.
126. Hironori Hamano, Ichiro Saito, Norio Haneji, Yuriko Mitsuhashi, Nobuyuki Miyasaka and Yoshio Hayashi :
Expression of cytokine genes during development of autoimmune sialadenitis in MRL/lpr mice,
European Journal of Immunology, Vol.23, No.10, 2387-2391, 1993.
(DOI: 10.1002/eji.1830231002,   PubMed: 8405038)
127. Hiroyo Deguchi, Hironori Hamano and Yoshio Hayashi :
c-myc, ras p21 and p53 expression in pleomorphic adenoma and its malignant form of the human salivary glands,
Acta Pathologica Japonica, Vol.43, No.7-8, 413-422, 1993.
(PubMed: 8396843)
128. Hiroyo Deguchi, Hironori Hamano, Norio Haneji, Mariko Takahashi and Yoshio Hayashi :
Immunopathology of phenotypic change on human parotid gland adenocarcinoma,
Pathobiology, Vol.61, No.2, 83-88, 1993.
(PubMed: 7692875)
129. Youji Miyamoto, 滝下 幸夫, 林 英司, Masaru Nagayama, 東 富雄, Yoshio Hayashi, 高橋 敬治 and 宇山 正 :
顎下腺と肺の重複癌の1例,
日本口腔腫瘍学会誌, Vol.4, No.2, 264-269, 1992.
130. Shinya Kawata, Eiji Hayashi, Youji Miyamoto, Masaru Nagayama, Hiroyo Deguchi, Tomio Azuma and Yoshio Hayashi :
Four cases of cementifying fibroma,
Japanese Journal of Oral & Maxillofacial Surgery, Vol.38, No.3, 479-485, 1992.
131. Eiji Hayashi, Akio Hori, Youji Miyamoto, Masaru Nagayama, Hiroyo Deguchi and Yoshio Hayashi :
Lung carcinoma suspected to metastarize to the submandibular region by the autopsy, --- Report of a case ---,
Japanese Journal of Oral & Maxillofacial Surgery, Vol.38, No.4, 679-680, 1992.
132. 三橋 由利子, 出口 博代 and Yoshio Hayashi :
ヒト口唇粘膜メラノサイトの分布とその加齢および性別変化,
Journal of The Japanese Stomatological Society, Vol.40, No.4, 766-771, 1991.
133. Youji Miyamoto, Masaru Nagayama and Yoshio Hayashi :
A Cleft Child With Lobulated Tongue and Lingual Hamartoma: Report of a Case,
Journal of Oral and Maxillofacial Surgery, Vol.49, No.6, 644-646, 1991.
(DOI: 10.1016/0278-2391(91)90348-P,   PubMed: 2037922)
134. Katsuhiro Yasuda, Kazuhito Satomura, Masaru Nagayama, Yoshio Hayashi and Atsuhito Nakanishi :
The behavior of human ameloblastoma tissue in collagen matrix in vitro:an immunohistochemical study,
Journal of Oral Pathology & Medicine, Vol.20, No.4, 187-190, 1991.
135. Youji Miyamoto, Fumihiro Matsumoto, Yukio Takishita, Masaru Nagayama, Hiroyo Deguchi and Yoshio Hayashi :
Solitary neurofibroma of the tongue: Report of a case,
Japanese Journal of Oral & Maxillofacial Surgery, Vol.37, No.6, 1187-1188, 1991.
136. Kenji Fujisawa, Hiroaki Nakanishi, Kazuhito Satomura, 安田 勝裕, Youji Miyamoto, Masaru Nagayama, 出口 博代 and Yoshio Hayashi :
石灰化歯原性嚢胞の3例,
Journal of The Japanese Stomatological Society, Vol.40, No.4, 900-911, 1991.
137. Akiyo Nakahata, Hiroyo Deguchi, Tetsuo Yanagawa, Hideo Yoshida, Mitsunobu Sato and Yoshio Hayashi :
Coexpression of intermediate-sized filaments in sialadenoma papilliferum and other salivary gland neoplasms,
Journal of Oral Pathology & Medicine, Vol.19, No.7, 313-318, 1990.
138. Yoshio Hayashi, Tamiko Takemura, Takumi Akashi, Yukiyoshi Esaki, Chieri Kurashima and Katsuiku Hirokawa :
Immunopathological analysis of interstitial renal lesions in elderly people,
Pathobiology, Vol.58, No.4, 230-235, 1990.
139. Yoshio Hayashi, Hiroyo Deguchi, Akiyo Nakahata, Chieri Kurashima and Katsuiku Hirokawa :
Immunopathological study of neuropeptide expression in human salivary gland neoplasms,
Pathobiology, Vol.58, No.4, 212-220, 1990.
(DOI: 10.1159/000163587,   PubMed: 1701303)
140. Yoshio Hayashi, M Utsuyama, C Kurashima and K Hirokawa :
Spontaneous development of organ-specific autoimmune lesions in aged C57BL/6 mice,
Clinical and Experimental Immunology, Vol.78, No.1, 120-126, 1989.
141. Yoshio Hayashi, T Hiyoshi, T Takemura, C Kurashima and K Hirokawa :
Focal lymphocytic infiltration in the adrenal cortex of the elderly: immunohistological analysis of infiltrating lymphocytes,
Clinical and Experimental Immunology, Vol.77, No.1, 1019-105, 1989.
142. Yoshio Hayashi, Tamiko Takemura and Katsuiku Hirokawa :
Expression of neuron-specific enolase, Leu-7, and neuropeptides in human fetal salivary gland epithelium,
The Journal of Histochemistry and Cytochemistry, Vol.37, No.7, 1147-1152, 1989.
143. Yoshio Hayashi and K Hirokawa :
Immunopathology of experimental autoallergic sialadenitis in C3H/He mice,
Clinical and Experimental Immunology, Vol.75, No.3, 471-476, 1989.
144. Yoshio Hayashi, Akinori Kojima, Mami Hata and Katsuiku Hirokawa :
A new mutation involving the sublingual gland in NFS/N mice, --- Partially arrested mucous cell differentiation ---,
The American Journal of Pathology, Vol.132, No.2, 187-191, 1988.
145. Yoshio Hayashi, C Kurashima, M Utsuyama and Katsuiku Hirokawa :
Spontaneous development of autoimmune sialadenitis in aging BDF1 mice,
The American Journal of Pathology, Vol.132, No.1, 173-179, 1988.
(PubMed: 3260751)
146. Yoshio Hayashi, Tetsuo Yanagawa, Hideo Yoshida, Masayuki Azuma, Toshinobu Nishida, Yoshiaki Yura and Mitsunobu Sato :
Expression of vasoactive intestinal polypeptide and amylase in a human parotid gland adenocarcinoma cell line in culture,
Journal of the National Cancer Institute, Vol.79, No.5, 1025-1037, 1987.
147. Yoshio Hayashi, Shinichi Nagamine, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura, Masayuki Azuma and Mitsunobu Sato :
Small cell undifferentiated carcinoma of the minor salivary gland containing exocrine, neuroendocrine, and squamous cells,
Cancer, Vol.60, No.7, 1583-1588, 1987.
148. Yoshio Hayashi, Hideo Yoshida, Shinichi Nagamine, Tetsuo Yanagawa, Yoshiaki Yura, Masayuki Azuma and Mitsunobu Sato :
Induction of cells with acinar cell phenotype including presence of intracellular amylase, --- Treatment with 12-O-tetradecanoyl-phorbol-13-acetate in a neoplastic human salivary intercalated duct cell line grown in athymic nude mice ---,
Cancer, Vol.60, No.5, 1000-1008, 1987.
149. Yoshio Hayashi, Toshinobu Nishida, Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura and Mitsunobu Sato :
Immunoreactive vasoactive intestinal polypeptide in acinic cell carcinoma of the parotid gland,
Cancer, Vol.60, No.5, 962-968, 1987.
150. Masayuki Azuma, Furumoto Nanayo, Kawamata Hitoshi, Hideo Yoshida, Yanagawa Tetsushi, Yura Yoshiaki, Yoshio Hayashi, Yoshihiro Takegawa and Mitsunobu Sato :
The relation of ras oncogene product p21 expression to clinocopathological status criteria and clinical outcome in squamous cell head and neck cancer,
The Cancer Journal, Vol.1, No.9, 375-380, 1987.
151. Toshinobu Nishida and Yoshio Hayashi :
ヒト唾液VIP様免疫活性の検出,
ホルモンと臨床, Vol.35, No.9, 81-84, 1987.
152. Tetsuo Yanagawa, Yoshio Hayashi, Hideo Yoshida, Yoshiaki Yura, Shinichi Nagamine, Takashi Bando and Mitsunobu Sato :
An adenoid squamous carcinoma-forming cell line established from an oral keratinizing squamous cell carcinoma expressing carcinoembryonic antigen,
The American Journal of Pathology, Vol.124, No.3, 496-509, 1986.
153. Yoshio Hayashi, Hideo Yoshida, Toshinobu Nishida, 永峰 伸一, 梁川 哲雄, 由良 義明 and Mitsunobu Sato :
耳下腺腺房細胞癌におけるVIPの発現,
Journal of Clinical and Experimental Medicine, Vol.138, No.3, 207-208, 1986.
154. Yoshio Hayashi, Haruhiko Saito, Shiro Saito, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura and Mitsunobu Sato :
Immunoreactive somatostatin in Warthin's tumor,
The American Journal of Pathology, Vol.123, No.2, 250-255, 1986.
155. Yoshio Hayashi, Yoshiaki Yura, Hideo Yoshida, Tetsuo Yanagawa and Mitsunobu Sato :
Development of allergic sialadenitis in mice immunized with mumps virus-infected submandibular salivary gland,
The American Journal of Pathology, Vol.123, No.2, 271-279, 1986.
156. Yoshio Hayashi, Hideo Yoshida, Furumoto Nanako, Yanagawa Tetsuo, Yura Yoshiaki, Yoshihiro Takegawa and Mitsunobu Sato :
Monoclonal antibody analysis of peripheral blood lymphocyte subpopulations in squamous cell head and neck cancer,
The Cancer Journal, Vol.1, No.1, 25-29, 1986.
157. Masayuki Azuma, Yoshio Hayashi, Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura, Akemichi Ueno and Mitsunobu Sato :
Emergence of differentiated subclones from a human salivary adenocarcinoma cell clone in culture after treatment with sodium butyrate,
Cancer Research, Vol.46, No.2, 770-777, 1986.
158. Toshinobu Nishida and Yoshio Hayashi :
RIA法によるヒト唾液epidermal growth factorの測定意義,
Journal of Clinical and Experimental Medicine, Vol.136, No.136, 61-62, 1986.
159. Tetsuo Yanagawa, Yoshio Hayashi, Toshinobu Nishida, Hideo Yoshida, Yoshiaki Yura, Masayuki Azuma and Mitsunobu Sato :
Immunohistochemical demonstration of carcinoembryonic antigen (CEA) on tissue sections from squamous cell head and neck cancer and plasma CEA levels of the patients,
International Journal of Oral and Maxillofacial Surgery, Vol.15, No.3, 296-306, 1986.
160. M Urata, Toshinobu Nishida, Yoshio Hayashi, Hideo Yoshida, N Furumoto, T Yanagawa, Y Yura and Mitsunobu Sato :
Immunoglobulin A circulating immune complexes in oral squamous cell cancer,
The Cancer Journal, Vol.1, No.2, 68-71, 1986.
161. Mitsunobu Sato, Hideo Yoshida, Yoshio Hayashi, Kenji Miyakami, Takashi Bando, Tetsuo Yanagawa, Yura Yura, Masayuki Azuma and Akemichi Ueno :
Expression of epidermal growth factor and transforming growth factor-beta in human salivary gland adenocarcinoma cell line,
Cancer Research, Vol.45, No.12 P 1, 6160-6167, 1985.
162. Mitsunobu Sato, Yoshio Hayashi, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura, Masayuki Azuma and Akemichi Ueno :
Intermediate-sized filaments and specific markers in a human salivary gland adenocarcinoma cell line and its nude mouse tumors,
Cancer Research, Vol.45, No.8, 3837-3790, 1985.
163. Yoshio Hayashi, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura, Toshiharu Nitta and Mitsunobu Sato :
Induction of other differentiation stages in neoplastic epithelial duct and myoepithelial cells from the human salivary gland grown in athymic nude mice,
Cancer, Vol.55, No.11, 2575-2583, 1985.
164. Yoshio Hayashi, Mitsunobu Sato and Katsuiku Hirokawa :
Induction of experimental allergic sialadenitis in mice,
The American Journal of Pathology, Vol.118, No.3, 476-483, 1985.
165. Yoshio Hayashi, Toshinobu Nishida, 古本 奈奈代, Hideo Yoshida, 梁川 哲雄, 由良 義明 and Mitsunobu Sato :
頭頸部癌患者の血清β2-microglobulin,
Journal of Clinical and Experimental Medicine, Vol.131, No.7, 451-452, 1984.
166. Toshinobu Nishida, Yoshio Hayashi and 中村 観善 :
臨床参考値の年齢差および性差について,
The Official Journal of Japanese Society of Laboratory Medicine, Vol.32, No.11, 1263-1270, 1984.
167. Mitsunobu Sato, Hideo Yoshida, Yanagawa Tetsuo, Yura Yoshiaki, Urata Mitsuru, Masayuki Azuma, Furumoto Nanayo, Yoshio Hayashi and Yoshihiro Takegawa :
Interferon Activity and Its Characterization in the Sera of Patients with Head and Neck Cancer,
Cancer, Vol.54, No.1, 1239-1251, 1984.
168. Yoshio Hayashi, Toshinobu Nishida, Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura, Nanayo Furumoto and Mitsunobu Sato :
Peripheral Tγ lymphocyte population in head and neck cancer,
Cancer Immunology, Immunotherapy, Vol.17, No.3, 160-164, 1984.
(DOI: 10.1007/BF00205480,   PubMed: 6236876)
169. Toshinobu Nishida, Yoshio Hayashi, Hideo Yoshida, Mitsunobu Sato, 小阪 昌明 and 斎藤 史郎 :
唾液分泌型 IgA の酵素免疫測定法とその臨床的意義,
Journal of Clinical and Experimental Medicine, Vol.129, No.11, 767-770, 1984.
170. Yoshio Hayashi, Toshinobu Nishida, Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura, Toshiharu Nitta and Mitsunobu Sato :
Peripheral K-lymphocyte population in head and neck cancer,
Cancer, Vol.53, No.11, 2507-2514, 1984.
171. Mitsunobu Sato, Yoshio Hayashi, Hideo Yoshida, Tetsuo Yanagawa and Yoshiaki Yura :
A family with hereditary lack of T4+ inducer/helper T cell subsets in peripheral blood lymphocytes,
The Journal of Immunology, Vol.132, No.3, 1071-1073, 1984.
172. Yoshio Hayashi, Mitsunobu Sato, 古本 奈奈代, Hideo Yoshida, 梁川 哲雄, 由良 義明 and Toshinobu Nishida :
頭頸部癌患者末梢血リンパ球サブセットの異常,
Journal of Clinical and Experimental Medicine, Vol.128, No.8, 507-508, 1984.
173. Mitsunobu Sato, Hideo Yoshida, Yanagawa Tetsuo, Yura Yoshiaki, Urata Mitsuru, Atsumi Masahiro, Yoshio Hayashi and Yoshihiro Takegawa :
Effects of intradermal administration of streptococcal preparation OK-432 on interferon and natural killer cell activities in patients with oral cancer,
International Journal of Oral Surgery, Vol.13, No.1, 7-15, 1984.
174. Yoshio Hayashi, Toshinobu Nishida, Hideo Yoshida, 梁川 哲雄, 由良 義明 and Mitsunobu Sato :
頭頸部眼患者からみたTγ細胞の機能,
Clinical Immunology, Vol.16, No.5, 416-425, 1984.
175. Yoshio Hayashi, Mitsunobu Sato, 古本 奈奈代, Hideo Yoshida, Toshinobu Nishida, 浜野 修一 and 中嶋 克行 :
単クローン抗体によるヒトリンパ球サブセットの加齢および性別変化,
Journal of Clinical and Experimental Medicine, Vol.127, No.1, 25, 1983.

Academic Paper (Unrefereed Paper):

1. Naozumi Ishimaru, 岸本 英博, Yoshio Hayashi and Sprent Jonathan :
NF-kB2によるT細胞の新たな調節機構,
実験医学 月刊, Vol.24, No.16, 2513-2516, 2006.
2. Reza Shiari, Ichiro Kobayashi, Nariaki Toita, Norikazu Hatano, Nobuaki Kawamura, Motohiko Okano, Yoshio Hayashi, Kunihiko Kobayashi and Tadashi Ariga :
Epitope mapping of anti-alpha-fodrin autoantibody in juvenile Sjögren's syndrome: difference in major epitopes between primary and secondary cases.,
The Journal of Rheumatology, Vol.33, No.7, 1395-1400, 2006.
(PubMed: 16821274)
3. Yoshio Hayashi, Naozumi Ishimaru and Rieko Arakaki :
RbAp48遺伝子導入マウスにおけるシェーグレン症候群様病態の出現,
Clinical Immunology, Vol.45, No.5, 533-537, 2006.

Review, Commentary:

1. Rieko Arakaki, Akiko Yamada, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru :
Mechanism of Activation-Induced Cell Death of T Cells and Regulation of FasL Expression.,
Critical Reviews in Immunology, Vol.34, No.4, 301-314, May 2014.
(DOI: 10.1615/CritRevImmunol.2014009988,   PubMed: 24941158,   Elsevier: Scopus)
2. Yoshio Hayashi, Rieko Arakaki and Naozumi Ishimaru :
Sjogren's syndrome,
The Journal of the Japanese Society of Internal Medicine, Vol.100, No.5, 1262-1268, Jun. 2011.
(DOI: 10.2169/naika.100.1262,   CiNii: 10029097111,   Elsevier: Scopus)
3. Naozumi Ishimaru, Takashi Izawa and Yoshio Hayashi :
Regulation of immune response by RANKL and Fas,
Clinical Immunology & Allergology, Vol.55, No.2., 142-147, Apr. 2011.
(CiNii: 40018745171)
4. Rieko Arakaki, Naozumi Ishimaru and Yoshio Hayashi :
Immunotherapeutic targets in estrogen deficiency-dependent Sjögren's syndrome-related manifestations,
Immunotherapy, Vol.2, No.3, 339-346, May 2010.
(DOI: 10.2217/imt.10.18,   PubMed: 20635899)
5. Takashi Izawa, Naozumi Ishimaru, Eiji Tanaka and Yoshio Hayashi :
Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance,
Clinical Immunology & Allergology, Vol.52, No.5, 471-477, Nov. 2009.
(CiNii: 40016915514)
6. Naozumi Ishimaru, 岸本 英博, Yoshio Hayashi and Sprent Jonathan :
NF-kB2によるT細胞の新たな調節機構,
Experimental Medicine, Vol.24, No.16, 2513-2516, Jan. 2007.
7. Naozumi Ishimaru and Yoshio Hayashi :
Crucial Roles of NF-κB for T Cell Activation,
Journal of Oral Biosciences, Vol.48, No.1, 12-17, Feb. 2006.
(DOI: 10.1016/S1349-0079(06)80014-9,   Elsevier: Scopus)
8. Yoshio Hayashi, Rieko Arakaki and Naozumi Ishimaru :
エストロゲンと自己免疫疾患,
Annual Review糖尿病・代謝・内分泌2006, 241-246, Jan. 2006.
9. Yoshio Hayashi, 石丸 直澄 and 新垣 理恵子 :
RbAp48遺伝子マウスにおけるシェーグレン様病態の出現,
Clinical Immunology, No.45, 533-537, 2006.
10. Masami Takei, Hidetaka Shiraiwa, Takashi Azuma, Yoshio Hayashi, Naoyuki Seki and Shigemasa Sawada :
The possible etiopathogenic genes of Sjögren's syndrome,
Autoimmunity Reviews, Vol.4, No.7, 479-484, Sep. 2005.
(DOI: 10.1016/j.autrev.2005.05.003,   PubMed: 16137615)
11. Yoshio Hayashi, Naozumi Ishimaru and 表原 文江 :
唾液腺の自己免疫病変,
病理と臨床, No.25, 116-121, 2005.
12. Yoshio Hayashi, Naozumi Ishimaru and Fumie Omotehara :
唾液腺の自己免疫病変,
病理と臨床, Vol.23, 116-121, 2005.
13. Takashi Fujibayashi, Susumu Sugai, Nobuyuki Miyasaka, Yoshio Hayashi and Kazuo Tsubota :
Revised Japanese criteria for Sjögrens syndrome (1999): availability and validity,
Modern Rheumatology, Vol.14, No.6, 425-434, Dec. 2004.
(DOI: 10.1007/s10165-004-0338-x)
14. Yoshio Hayashi, Rieko Arakaki and Naozumi Ishimaru :
Crucial Role of Tissue-Specific Apoptosis on the Development of Primary Sjogren's Syndrome,
Oral Science International, Vol.1, No.2, 55-64, Nov. 2004.
(DOI: 10.1016/S1348-8643(04)80007-7,   CiNii: 10017396417)
15. Yoshio Hayashi, Rieko Arakaki and Naozumi Ishimaru :
Apoptosis and Estrogen Deficiency in Primary Sjögren Syndrome,
Current Opinion in Rheumatology, Vol.16, No.5, 522-526, Sep. 2004.
(DOI: 10.1097/01.bor.0000135450.78047.78,   PubMed: 15314488)
16. Yoshio Hayashi, Hitomi Fukui and Naozumi Ishimaru :
Aging and Autoimmune Diseases,
日本アフェレシス学会雑誌, Vol.23, No.2, 176-181, May 2004.
17. Yoshio Hayashi, Rieko Arakaki and Naozumi Ishimaru :
The role of caspase cascade on the development of primary Sjogren's syndrome,
The Journal of Medical Investigation : JMI, Vol.50, No.1,2, 32-38, Feb. 2003.
(Tokushima University Institutional Repository: 110675,   PubMed: 12630566)
18. Yoshio Hayashi, Rieko Arakaki and Naozumi Ishimaru :
シェーグレン症候群発症の分子機構,
Clinical Immunology, Vol.40, 196-204, 2003.
19. 渡辺 恵, 市川 哲雄, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
接触性過敏症における樹状細胞の役割,
アレルギー科, Vol.15, 481-487, 2003.
20. Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
自己免疫疾患の発症とアポトーシス,
細胞, Vol.35, 20-23, 2003.
21. Yoshio Hayashi and Naozumi Ishimaru :
自己免疫疾患における分子模倣仮説,
Journal of Clinical and Experimental Medicine, Vol.206, 855-858, 2003.
22. Yoshio Hayashi, Rieko Arakaki and Naozumi Ishimaru :
シェ-グレン症候群発症の分子機構,
Clinical Immunology, Vol.40, 196-204, 2003.
23. Yoshio Hayashi :
シェーグレン症候群の新しい話題,
Progress in Medicine, Vol.22, 38-42, 2002.
24. Yoshio Hayashi :
シェーグレン症候群と動物モデル,
アレルギー・免疫, Vol.8, No.9, 40-47, Sep. 2001.
25. Yoshio Hayashi :
シェーグレン症候群の病因抗原,
Japan Medical Journal, Vol.4035, 12-14, Aug. 2001.
26. Yoshio Hayashi :
An essential role of apoptotic protease cascade in the pathogenesis of Sjogren's syndrome,
Dentistry in Japan, Vol.37, 16-19, Mar. 2001.
27. Yoshio Hayashi :
シェーグレンモデルマウス,
分子細胞治療, Vol.2, 99-104, 2001.
28. Yoshio Hayashi :
難治性口腔免疫疾患:シェーグレン症候群,ベーチェット病,天疱瘡など,
病理と臨床, Vol.19, 228-232, 2001.
29. Yoshio Hayashi :
シェーグレン症候群自己抗原αーフォドリンの病因的意義,
リウマチ科, Vol.23, 191-198, 2000.
30. 斎藤 一郎 and Yoshio Hayashi :
IL-10とシェーグレン症候群,
Immunology Frontier, Vol.10, 36-40, 2000.
31. Yoshio Hayashi, Kumiko Yanagi and Norio Haneji :
Involvement of apoptotic protease cascade for tissue destruction in Sjogren's syndrome,
Archivum Immunologiae et Therapiae Experimentalis, Vol.48, No.5, 399-403, 2000.
(PubMed: 11140467)
32. Yoshio Hayashi :
シェーグレン症候群:モデルマウスとヒトの疾患,
BIO Clinica, Vol.14, 28-33, Apr. 1999.
33. Yoshio Hayashi :
αーフォドリン,
KEY WORD 1999-2000 膠原病, 148-149, 1999.
34. Yoshio Hayashi :
Sjogren症候群とαーfodrin,
神経内科, Vol.51, 117-124, 1999.
35. Yoshio Hayashi :
シェーグレン症候群の発症に関与する自己抗原,
Inflammation & Immunology, Vol.7, 59-64, 1999.
36. Yoshio Hayashi, 柳 久美子 and Naozumi Ishimaru :
免疫異常からみたリウマチ性疾患の臓器病変:口腔内病変,
リウマチ科, Vol.21, 630-638, 1999.
37. Yoshio Hayashi :
Sjogren症候群のターゲット,αーフォドリン,
内科, Vol.83, No.1, 116-118, 1999.
38. 斎藤 一郎 and Yoshio Hayashi :
Sjogren症候群の臓器特異的自己抗原の検出とその成立機序,
Annual Review, 307-313, Dec. 1998.
39. Yoshio Hayashi :
シェーグレン症候群における臓器特異的自己抗原の同定,
Seikagaku, Vol.70, No.5, 381-385, May 1998.
40. Yoshio Hayashi :
シェーグレン症候群における自己抗原αーフォドリンの同定とその意義,
Clinical Immunology, Vol.30, 967-970, 1998.
41. Yoshio Hayashi :
シェーグレン症候群の原因抗原,
Infection, Inflammation & Immunity, Vol.28, 60-62, 1998.
42. Yoshio Hayashi :
シェーグレン症候群とその病因の解明,
モダンメディア別冊, Vol.44, 151-156, 1998.
43. Yoshio Hayashi, 柳 久美子 and 羽地 則雄 :
Sjogren症候群の新たな自己抗原,
最新医学, Vol.53, No.3, 545-554, 1998.
44. Yoshio Hayashi :
The immunology of Sjogren's syndrome: emphasis on the role of salivary gland autoantigen,
Biomedical Reviews, Vol.9, 131-141, 1998.
45. Yoshio Hayashi :
シェーグレン症候群における免疫機構,
BIO Clinica, Vol.12, No.9, 81-84, Aug. 1997.
46. Yoshio Hayashi :
シェーグレン症候群 原因自己抗原の解明,
難病と在宅ケア, Vol.3, No.5, 8-11, Aug. 1997.
47. 羽地 則雄 and Yoshio Hayashi :
シェーグレン症候群モデルマウスにおける臓器特異的自己抗体,
リウマチ, Vol.97, 95-101, 1997.
48. Yoshio Hayashi :
Sjogren症候群疾患モデルと臓器特異的自己抗原,
Molecular Medicine, Vol.34, 1425-1429, 1997.
49. Yoshio Hayashi :
Cytokines, adhesion molecules, and immune deviation in autoimmune salivary,
Oral Medicine & Pathology, Vol.1, No.1, 3-10, Jun. 1996.
(CiNii: 110002985147)
50. Yoshio Hayashi :
老化と自己免疫,免疫疾患,
Experimental Medicine, 144, 1996.
51. Yoshio Hayashi, Norio Hneji and Hironori Hamano :
Sjogren's syndrome of MRL/lpr mice,
Autoimmunity, Vol.23, No.4, 269-277, 1996.
52. Yoshio Hayashi :
シェーグレン症候群各種動物モデルによる実験的研究の動向と成果,
Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.53, No.10, 25-30, Oct. 1995.
53. Yoshio Hayashi :
老化に伴う自己免疫現象,
Journal of Clinical and Experimental Medicine, 198-201, 1995.
54. Yoshio Hayashi :
唾液腺,
Journal of Medical Technology, Vol.39, No.11, 134-136, 1995.
55. Ichiro Saito, Yoshio Hayashi and Roland Jonsson :
Sjogren's Syndrome,Systemic Lupus Erythematosus and Oral Mucosal Immunity,
Mucosal Immunology Update, Vol.3, No.2, 1-5, 1995.
56. Yoshio Hayashi, Norio Haneji and Hironori Hamamoto :
Pathogenesis of Sjogren's syndrome-like autoimmune lesions in MRL/lpr mice,
Pathology International, Vol.44, No.8, 559-568, Aug. 1994.
57. Yoshio Hayashi :
シェーグレン症候群の病因解析,
The Medical Frontline, Vol.49, No.1, 151-156, Jan. 1994.
58. Yoshio Hayashi :
老化と自己免疫 エイジングの科学,
現代化学, 165-169, 1994.
59. Yoshio Hayashi :
自己免疫疾患の発症機構におけるT細胞の役割,
Clinical Immunology, Vol.26, No.7, 776-783, 1994.
60. 浜野 弘規, 三橋 由利子 and Yoshio Hayashi :
Sjogren症候群の病態と病理,
Journal of Clinical and Experimental Medicine, Vol.163, No.1, 45-48, 1992.
61. Yoshio Hayashi :
Sjogren症候群疾患モデルの現状と展望,
Journal of Clinical and Experimental Medicine, Vol.163, No.1, 109-112, 1992.
62. Yoshio Hayashi :
シェーグレン症候群疾患モデルによる病因解析の展望,
Clinical Immunology, Vol.24, No.3, 351-362, 1992.
63. Yoshio Hayashi, Hiroyo Deguchi, Yuriko Mitsuhashi and Hironori Hamamoto :
Interstitial renal leions as a autoimmune phenomenon in the aged,
Geriatric Nephrol Urol, Vol.1, No.3, 191-199, 1992.
64. Yoshio Hayashi :
加齢に伴う自己免疫性臓器病変,
Clinical Immunology, Vol.23, No.7, 1056-1065, Jul. 1991.
65. Yoshio Hayashi, Hiroyo Deguchi, Akiyo Nakahata, Chieri Kurashima, Masanori Utsuyama and Katsuiku Hirokawa :
Autoimmune sialadenitis: possible models for Sjogren's syndrome and a common aging phenomenon,
Autoimmunity, Vol.5, No.3, 215-228, 1990.
66. Yoshio Hayashi :
高齢者剖検例にみられる自己免疫性臓器病変,
病理と臨床, Vol.7, No.11, 1389-1392, 1989.
67. Mitsunobu Sato, Yoshio Hayashi, Hideo Yoshida and 梁川 哲雄 :
ヒト唾液腺癌細胞の増殖と分化,
The Journal of Clinical Science, Vol.21, No.8, 1065-1072, 1985.
68. Mitsunobu Sato, Hideo Yoshida and Yoshio Hayashi :
歯槽歯肉癌,
Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.42, 952-958, 1984.
69. Yoshio Hayashi :
病理検査,
The Journal of Dental Medecine, Vol.17, No.3, 359-372, 1983.

Proceeding of International Conference:

1. Akiko Yamada, Rieko Arakaki, Mie Kurosawa, Tomoyuki Kondo, Koichi Yamada, Yoshio Hayashi and Naozumi Ishimaru :
Deficient differentiation of Treg cell in a murine model of Sjogren's syndrome.,
15th International Congress of Immunology, Milan, Aug. 2013.
2. Yosuke Shikama, Naozumi Ishimaru, Yasusei Kudo, Yukiko Bandou, Nanako Aki, Yoshio Hayashi and Makoto Funaki :
High Levels of Free Fatty Acids May Advance the Severity of Primary Sjögrens Syndrome,
Diabetes, Vol.62, No.Supplement 1, A166, Jul. 2013.
3. Masahiro Hiasa, Masahiro Abe, Rieko Arakaki, Akiko Yamada, Kenzo Asaoka, Toshio Matsumoto, Yoshio Hayashi and Naozumi Ishimaru :
RelB attenuates the activation of the classical NF-κB pathway to facilitate osteoblastogenesis,
ANZBMS Annual Scientific Meeting, Perth, Sep. 2012.
4. Ritsuko 徳永 律子 Oura, Akiko Yamada, Rieko Arakaki, Naozumi Ishimaru and Yoshio Hayashi :
Pathological Analysis of Autoimmunity in NF-B1KO/LPR mice.,
8th International Congress on Autoimmunity, Granada, May 2012.
5. Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8+T cell activity.,
8th International Congress on Autoimmunity, Granada, May 2012.
6. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Masahiro Hiasa, Yoshio Hayashi and Eiji Tanaka :
Hyperfunctions of osteoclasts in a rheumatoid arthritis model,
ASBMR 2011 Annual Meeting, San Diego, Sep. 2011.
7. Kazuma Matsumoto, Naozumi Ishimaru, Yoshio Hayashi and Eiji Tanaka :
Analysis of osteoclast activation in the pathogenesis of rheumatoid arthritis,
International Joint Symposium: The University of Tokushima, Universitas Gadjah Mada, Niigata University, Denpasar, Bali, Dec. 2010.
8. Ashrin Nur Meinar, Naozumi Ishimaru, Megumi Watanabe, Yoshio Hayashi and Tetsuo Ichikawa :
Analysis of Molecular Mechanism for Pathogenesis of Metal Allergy,
International Joint Symposium, The University of Tokushima-Niigata University-Gajah Mada University, Bali, Dec. 2010.
9. Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki, Yousuke Takahama and Yoshio Hayashi :
Critical Signaling Pathway via CCR7 of Foxp3+CD25+CD4+ Regulatory T Cells for the Egress from Lymph Nodes,
international immunology, Aug. 2010.
10. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Rieko Arakaki, Ritsuko 徳永 律子 Oura, Eiji Tanaka and Yoshio Hayashi :
Fas-independent apoptosis of T cells via DCs controls autoimmune arthritis,
international immunology, Vol.22, No.1, 113, Aug. 2010.
11. Ritsuko 徳永 律子 Oura, Naozumi Ishimaru, Rieko Arakaki, Takashi Izawa, Akiko Yamada, Kazuma Matsumoto, Eiji Tanaka and Yoshio Hayashi :
Rapid T cell death via interaction with CD11b+ macrophages in Fas-deficient host,
international immunology, Vol.22, No.1, 116, Aug. 2010.
12. Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki, Yousuke Takahama and Yoshio Hayashi :
Critical signaling pathway via CCR7 of Foxp3+CD25+CD4+ regulatory T cells for the egress from lymph nodes.,
第14回国際免疫学会, Kobe, Aug. 2010.
13. Ritsuko 徳永 律子 Oura, Naozumi Ishimaru, Eiji Tanaka and Yoshio Hayashi :
Rapid peripheral T cell death in Fas-deficient mice,
88th IADR, Barcelona, Jul. 2010.
14. Nao Kinouchi, Emi Kawakami, Yutaka Ohsawa, Naozumi Ishimaru, Hideyo Ohuchi, Yoshihide Sunada, Yoshio Hayashi, Eiji Tanaka and Sumihare Noji :
Atelocollagen-mediated Systemic Administration of Myostatin siRNA Improves Muscular Dystrophy,
88th IADR, Barcelona, Jul. 2010.
15. Emi Kawakami, Nao Kinouchi, Adachi Taro, Yutaka Ohsawa, Naozumi Ishimaru, Hideyo Ohuchi, Yoshihide Sunada, Yoshio Hayashi, Eiji Tanaka and Sumihare Noji :
Special Processed Collagen-mediated Application of Myostatin-siRNA for Muscular Atrophy Diseases,
88th IADR, Barcelona, Jul. 2010.
16. Emi Kawakami, Nao Kinouchi, Yutaka Osawa, Naozumi Ishimaru, Hideyo Ohuchi, Yoshihide Sunada, Yoshio Hayashi, Eiji Tanaka and Sumihare Noji :
Strategic study of atelocollagen-mediated application of mystatin-targeting siRNA for therapeutic use for muscular atrophy diseases,
QOL International Congress, Niigata, Feb. 2010.
17. Takashi Sakai, HoangNam Tran, Sun Mi Kim, Li Liu, Xichuan Teng, Yuji Shishido, Mukai-Sakai Rika, Mitsuru Matsumoto, Kazunori Ishimura, Yoshio Hayashi, Ryuji Kaji and Kiyoshi Fukui :
Nucling, a novel stress-sensitive protein, regulates NF-kappa B activation,
The 4th International Congress on Stress Responses in Biology and Medicine, The 4th Annual Meeting of the Biomedical Society for Stress Response, Sapporo, Oct. 2009.
18. Takeo Iwata, Masamichi Kuwajima, Akiko Sukeno, Naozumi Ishimaru, Yoshio Hayashi, M Wabitsch, Noriko Mizusawa, Mitsuo Itakura and Katsuhiko Yoshimoto :
YKL-40 secreted from macrophages infiltrating into adipose tissue inhibits degradation of type I collagen.,
International symposium on diabetes, Tokyo, Mar. 2009.
19. Takashi Sakai, Li Liu, Xichuan Teng, Naozumi Ishimaru, Rika Sakai, HoangNam Tran, Nobuya Sano, Yoshio Hayashi, Ryuji Kaji and Kiyoshi Fukui :
Inflammatory disease and cancer with a decrease in Kupffer cell numbers in Nucling-konckout mouse,
20th FAOBMB Taipei Conference, Taipei, Oct. 2008.
20. Nao Kinouchi, Yutaka Osawa, Naozumi Ishimaru, Yoshio Hayashi, Keiji Moriyama, Sumihare Noji and Eiji Tanaka :
Atelocollagen-mediated lapplications of myostatin-targeting siRNA increase skeletal muscle mass,
86th IADR, Toronto, Jul. 2008.
21. Yoshio Hayashi and Naozumi Ishimaru :
Development of autoimmune expcrinopathy resembling Sjogren's syndrome in RbAp48 transgenic mice.,
Boston, Nov. 2007.
22. Takashi Izawa, Naozumi Ishimaru, Keiji Moriyama and Yoshio Hayashi :
Immunoregulatory Role of RANKL-stimulated Dendritic Cells on Autoimmune Arthritis in MRL/lpr Mice,
ACR/ARHP 71th Annual Scientific Meeting, Vol.56, No.Suppl 9, S-105, Boston, Nov. 2007.
23. Yoshio Hayashi and Naozumi Ishimaru :
Developmant of autoimmune excrinopathy resembling Sjorgen`s syndrome in RbAp48 transgenic mice.,
The 71st Annual meeting of the American College of Rheumatology., Bostone,USA., Nov. 2007.
24. Takashi Izawa, Naozumi Ishimaru, Keiji Moriyama and Yoshio Hayashi :
Immunoregulatory role of RANKL-stimulated dendritic cells on autoimmune arthritis in MRL/lpr mice,
29th Annual Meeting of the American Society for Bone and Mineral Research, Vol.22, No.SUPPL 1, S270, Honolulu, Sep. 2007.
25. Jun Ooshima, Takashi Izawa, Naozumi Ishimaru, Yoshio Hayashi and Keiji Moriyama :
Immunoregulatory Effects of Dendritic Cells Stimulated with RANKL on the Development of Autoimmune Disease in Arthritis Model Mice,
The 1st International Symposium and Workshop "The Future Direction of Oral Sciences in the 21st Century", 55, Awaji, Mar. 2007.
26. Yoshio Hayashi, N Ishimaru and N Katunuma :
Cathepsin L-inhibitor prevents proinsulin peptide processing and autimmune diabetes in nonobase diabetuc(NOD)mice.,
International Sympojium on Medical and biological Perspectives in proteases and Their Inhibitors., Awaji ,Japan, Jun. 2006.
27. Yoshio Hayashi :
NFS/sld mouse model for primary Sjogren's syndrome.,
8th International Symposium on Sjogren's Syndrome, Washington, D.C., Apr. 2006.
28. Yoshio Hayashi and N Ishimaru :
Involvement of interstitial oneumoina in Sjogren`s syndrome mouse model with aging., --- T Cell Immunity & Aging. ---,
Freudenstadt-Lauterbad,Germany, Dec. 2005.
29. Yoshio Hayashi and Naozumi Ishimaru :
Involvement of Interstitial Pneumonia in Sjogren's Syndrome Mouse Model with Aging.,
International Symposium on T Cells in Aging., Stuttgart, Dec. 2005.
30. Yoshio Hayashi, R Arakaki and N Ishimaru :
Possible mechanism of autoimmune exocrinopathy resembling Sjogren`s syndrome through RbAp48 overexpression., --- Gordon Research Conference on Salivary Glands & Exocrine Secretion. ---,
Ventura,USA., Feb. 2005.
31. Yoshio Hayashi, Rieko Arakaki and Naozumi Ishimaru :
Possible Mechanism of Autoimmune Exocrinopathy Resembling Sjogren's Syndrome through RbAp48 Overexpression.,
Gordon Research Conference., Ventura, Feb. 2005.
32. Yoshio Hayashi and N Ishimaru :
Development of autoimmune arthritis in Sjogren`s syndrome mouse model with aging via bystander T cell activation,
12th International Congress of Immunology, Montreal, Jul. 2004.
33. Takashi Izawa, Keiji Moriyama and Yoshio Hayashi :
Role of Dendritic Cells Stimulated with RANKL for Modulation of Autoimmune Arthritis in MRL/lpr Mice,
25th Annual Meeting of the American Society for Bone and Mineral Research, Vol.18, No.SUPPL 2, S396, Minneapolis, Sep. 2003.
34. Yoshio Hayashi, N Ishimaru, R Arakaki and N Katunuma :
Critical role of cathepsin inhibitors on autoantigen processing and autoimmunity,
44th International Symposium on Regulation of Enzyme Activity and Synthesis, Indianapolis,USA, Sep. 2003.
35. Yoshio Hayashi and N Ishimaru :
Role of estrogen-deficiency on the development of salivary gland autoimmunity,
Gordon Research Conference, Ventura,USA, Feb. 2003.
36. Yoshio Hayashi and N Ishimaru :
Induction of oral tolerance with epitope peptide of autoantigen in the aged mouse model for primary Sjogren`s syndrome,
3rd European Congress of Gerontology, Frenze,Italy, Nov. 2002.
37. Takashi Izawa, Keiji Moriyama and Yoshio Hayashi :
Acceleration of Autoimmune Arthritis in MRL/lpr Mice Transferred with RANKL-stimulated Dendritic cells,
24th Annual Meeting of the American Society for Bone and Mineral Research, Vol.17, No.SUPPL 1, S490, San Antonio, Sep. 2002.
38. Yoshio Hayashi :
Pathogenic T cell epitope on alpha-fodrin autoantigen in Sjogren`s syndrome,
VIIIth International Symposium on Sjogren`s Syndrome, Kanazawa, May 2002.
39. Yoshio Hayashi :
Immunodominant T cell epitope on alpha-fodrin autoantigen in primary Sjogren`s syndrome,
1st International Congress on Salivary Gland Diseases, Genwva,Switzerland, Jan. 2002.
40. Yoshio Hayashi :
Acceleration of autoimmune exocrinopathy with aging in murine Sjogren`s syndrome through Fas-medeated apoptosis,
The 17th Congress of the International Association of Gerontology, Vancouver, Jul. 2001.
41. K Yanagi, N Haneji, I Saito and Yoshio Hayashi :
Autoreactive T cell clone against alpha-fodrin in Sjogren`s syndrome,
XXIII International Congress of the International Academy of Pathology, Nagoya, Oct. 2000.
42. Yoshio Hayashi :
Breakdown product of alpha-fodrin as an important autoantigen in Sjogren's syndrome,
VIIth International Symposium on Sjogren's Syndrome, Venice,Italy, Dec. 1999.
43. Yoshio Hayashi :
The role for alpha-fodrin as an autoantigen in Sjogren's syndrome,
Gordon Research Conference, Ventura,USA, Feb. 1999.
44. Yoshio Hayashi :
Alpha-fodrin as a potential candidate autoantigen in Sjogren's sndrome,
VIth International Symposium on Sjogren's Syndrome, Avon,USA, Oct. 1997.
45. Yoshio Hayashi :
A new mouse model of primary Sjogren`s syndrome,
International Conference on Immunopathology of Mucous Membrane and Exocrine Organs, Bergen,Norway, May 1997.
46. Yoshio Hayashi, N Haneji and N Ishimaru :
Acceleration of age-related autoimmunity in MRL/+mice through oophorectomy,
International Conference on Immunology and Aging, Bethesda,Maryland,USA, Jun. 1996.
47. Maki Moritani, Katsuhiko Yoshimoto, J. Miyazaki, F. Tashiro, Setsuko Ii, Eiji Kudo, Hiroyuki Iwahana, Yoshio Hayashi, Toshiaki Sano and Mitsuo Itakura :
(Workshop) Local Production of IL-10 in Pancreatic Islet A-Cells in Transgenic NOD Mice Accelerates Autoimmune Insulitis and Diabetes.,
Combined Meeting of the 8th International Lymphokine Workshop and The 4th International Workshop on Cytokines, Osaka, Oct. 1993.

Proceeding of Domestic Conference:

1. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Masahiro Hiasa, Eiji Tanaka and Yoshio Hayashi :
関節リウマチモデルマウスにおける破骨細胞の機能解析,
The Annual Meeting of the Japanese Society for Bone and Mineral Research Program & Abstracts, 256,
2. Eiichiro Kitaoka, Nobuyuki Kamata, 山之内 浩司, Yukihiro Momota, Yoshio Hayashi and Masaru Nagayama :
6歳児の下顎骨に発生した若年性(侵襲性)化骨性線維種の1例,
第14回日本小児口腔外科学会,
3. Eiichiro Kitaoka, Hiroaki Nakanishi, Youji Miyamoto, Nobuyuki Kamata, Yoshio Hayashi and Masaru Nagayama :
長期にわたり経過覿察を行っている先天性舌リンパ管腫の1例,
第15回日本小児口腔外学会,
4. Eiichiro Kitaoka, Nobuyuki Kamata, Yukihiro Momota, 山之内 浩司, Kenji Fujisawa, 瀧 雅行, Yoshio Hayashi and Masaru Nagayama :
顎関節に発症した滑膜性軟骨腫症の1例,
第57回日本口腔科学会総会,
5. 久米 里織, 友成 真弓, 高野 栄之, Masaaki Takechi, Hiroaki Nakanishi, Yoshio Hayashi and Masaru Nagayama :
両側性に舌下型ガマ腫を発症したシェーグレン症候群の1例,
第52回日本口腔科学会地方会,
6. 山崎 泰文, Tetsuya Yuasa, Kazuhito Satomura, Naozumi Ishimaru, Yoshio Hayashi and Masaru Nagayama :
舌背部にみられた骨性分離腫の1例,
第53回日本口腔科学会中国・四国地方部会,
7. Tetsuya Yuasa, Hiroaki Nakanishi, 日比 弓紀子, 友成 真弓, Reiko Tokuyama, 前田 恵利子, Fumie Omotehara, Yoshio Hayashi and Masaru Nagayama :
耳下腺腫瘍との鑑別が困難であった木村氏病の1例,
第59回日本口腔科学会総会,
8. Keiko Kudoh, Kazuhito Satomura, 山崎 泰文, Masaaki Takechi, Naozumi Ishimaru, Yoshio Hayashi and Masaru Nagayama :
膿原性肉芽腫(pyogenic granuloma)の混在を認めた舌扁平上皮癌の1例,
第35回 日本口腔外科学会・中四国地方会,
9. Hiroyoshi Hosokawa, Kenji Fujisawa, Keiko Kudoh, Seiko Tatehara, Reiko Tokuyama, Yoshio Hayashi and Kazuhito Satomura :
上顎に発生した歯牙エナメル上皮腫の1例,
第53回日本口腔外科学会総会・学術大会(2008.10.20∼10.21徳島),
10. Akiko Yamada, Rieko Arakaki, Mie Kurosawa, Tomoyuki Kondoh, 常松 貴明, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru :
シェーグレン症候群の発症における制御性T細胞の役割,
日本病理学会会誌, Vol.103, No.1, 268, Apr. 2014.
11. Rieko Arakaki, Akiko Yamada, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru :
ニッケルアレルギー発症におけるThmic Stromal Lymphopoiethinの重要性,
日本病理学会会誌, Vol.103, No.1, 268, Apr. 2014.
12. Rieko Arakaki, Hiroshi Eguchi, Akiko Yamada, Yasusei Kudo, Yoshinori Mitamura, Yoshio Hayashi and Naozumi Ishimaru :
Eye drop administration of rebamipide is effective to a dry eye symptom in a model mice of Sjogren's syndorome.,
Proceedings of the Japanese Society for Immunology, Dec. 2013.
13. Rieko Arakaki, Akiko Yamada, Yasusei Kudo, Hiroshi Eguchi, Yoshinori Mitamura, Yoshio Hayashi and Naozumi Ishimaru :
シェーグレン症候群モデルを用いたレバミピド点眼薬によるドライアイの改善効果とその作用機序,
第102回日本病理学会, Jun. 2013.
14. Rieko Arakaki, Hiroshi Eguchi, Akiko Yamada, Yasusei Kudo, Yoshinori Mitamura, Yoshio Hayashi and Naozumi Ishimaru :
An Effective Therapy of Ocular Lesions in a Murine Model for Sjogren's Syndorome by Eye Drop Administration of Rebamipide.,
Proceedings of the Japanese Society for Immunology, Dec. 2012.
15. Akiko Yamada, Rieko Arakaki, Mie Kurosawa, Tomoyuki Kondo, Yasusei Kudo, Yoshio Hayashi and Naozumi Ishimaru :
Functional defect of Foxp3+Treg cells in Sjogren's syndrome.,
Proceedings of the Japanese Society for Immunology, Dec. 2012.
16. Masahiro Hiasa, Masahiro Abe, Rieko Arakaki, Akiko Yamada, Kenzo Asaoka, Toshio Matsumoto, Yoshio Hayashi and Naozumi Ishimaru :
RelB antagonizes the classical NF-κB pathway and its suppression of osteoblastogenesis,
第30回日本骨代謝学会, Jul. 2012.
17. Akiko Yamada, Rieko Arakaki, Yoshio Hayashi and Naozumi Ishimaru :
シェーグレン症候群における制御性T細胞の役割,
第101回日本病理学会, Apr. 2012.
18. Ritsuko 徳永 律子 Oura, Rieko Arakaki, Akiko Yamada, Yoshio Hayashi and Naozumi Ishimaru :
Fas分子を介したマクロファージによる末梢T細胞の維持機構,
第101回日本病理学会, Apr. 2012.
19. Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki and Yoshio Hayashi :
自己免疫疾患におけるCCR7を介した制御性T細胞のパトローリング機能,
第101回日本病理学会, Apr. 2012.
20. Rieko Arakaki, Akiko Yamada, Yoshio Hayashi, Hiroshi Eguchi, 三田村 さやか, 堀田 芙美香, Yoshinori Mitamura and Naozumi Ishimaru :
シェーグレン症候群モデルマウスを利用したレバミピド点眼投与による病態抑制機序の解明,
第101回日本病理学会, Apr. 2012.
21. Kazuma Matsumoto, Rieko Arakaki, Akiko Yamada, Masahiro Hiasa, Ritsuko 徳永 律子 Oura, 岩浅 亮彦, Eiji Tanaka, Yoshio Hayashi and Naozumi Ishimaru :
Hyperfunctions of osteoclasts in pathogenesis of rheumatoid arthritis in MRL/lpr mice.,
第40回日本免疫学会学術集会, Nov. 2011.
22. Masahiro Hiasa, Rieko Arakaki, Akiko Yamada, Ritsuko 徳永 律子 Oura, Masahiro Abe, Toshio Matsumoto, Yoshio Hayashi, Naozumi Ishimaru and Kenzo Asaoka :
A novel role of NF-B relB in bone remodeling.,
第40回日本免疫学会学術集会, Nov. 2011.
23. Ritsuko 徳永 律子 Oura, Rieko Arakaki, Masahiro Hiasa, Akiko Yamada, Eiji Tanaka, Yoshio Hayashi and Naozumi Ishimaru :
In vivo T cell apoptosis via interaction with CD11b+ macrophages in Fas-deficient host.,
Proceedings of the Japanese Society for Immunology, Vol.40, 111, Nov. 2011.
24. Akihiko Iwasa, Rieko Arakaki, Akiko Yamada, Eiji Tanaka, Yoshio Hayashi and Naozumi Ishimaru :
A critical role of aromatase in the pathogenesis of Sjogren's syndrome.,
Proceedings of the Japanese Society for Immunology, Vol.40, 127, Nov. 2011.
25. Rieko Arakaki, Akiko Yamada, Yoshio Hayashi and Naozumi Ishimaru :
The role of Th17 cell on the development of Sjogren's syndrome in estrogen deficient NOD mice.,
Proceedings of the Japanese Society for Immunology, Vol.40, 128, Nov. 2011.
26. Nur Meinar Ashrin, Megumi Watanabe, Rieko Arakaki, Akiko Yamada, Tetsuo Ichikawa, Yoshio Hayashi and Naozumi Ishimaru :
Analysis of Immune Responess to Metal using Murine Nickel Allergy Model.,
Proceedings of the Japanese Society for Immunology, Vol.40, 102, Nov. 2011.
27. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Masahiro Hiasa, Ritsuko 徳永 律子 Oura, Akihiko Iwasa, Yoshio Hayashi and Eiji Tanaka :
関節リウマチモデルマウスにおける破骨細胞の機能亢進,
日本矯正歯科学会大会プログラム・抄録集, 218, Oct. 2011.
28. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Masahiro Hiasa, Eiji Tanaka and Yoshio Hayashi :
関節リウマチモデルマウスにおける破骨細胞の機能解析,
The Annual Meeting of the Japanese Society for Bone and Mineral Research Program & Abstracts, 256, Jul. 2011.
29. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Ritsuko 徳永 律子 Oura, Akihiko Iwasa, Yoshio Hayashi and Eiji Tanaka :
Analysis for mechanism of T cell activation via osteoclast in rheumatoid arthritis,
Journal of the Japanese Society for the Temporomandibular Joint, Vol.23, 102, Jul. 2011.
30. Kazuma Matsumoto, Naozumi Ishimaru, Rieko Arakaki, Akiko Yamada, Eiji Tanaka and Yoshio Hayashi :
関節リウマチ病態における破骨細胞を介したT細胞活性化機構の解析,
第100回日本病理学会学術集会, Vol.100, No.1, 60, Apr. 2011.
31. Rieko Arakaki, Naozumi Ishimaru, Akiko Yamada and Yoshio Hayashi :
エストロゲン欠乏によって誘導されるシェーグレン症候群病態増強へのTh17細胞の関与,
第100回日本病理学会学術集会, Vol.100, No.1, 63, Apr. 2011.
32. Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki and Yoshio Hayashi :
自己免疫疾患の病態におけるメモリーCD8陽性T細胞の役割,
第100回日本病理学会学術集会, Vol.100, No.1, 59, Apr. 2011.
33. Naozumi Ishimaru, 本間 尚子, 吉村 憲子, 原田 信広 and Yoshio Hayashi :
自己免疫疾患におけるアロマターゼの役割,
第18回ステロイドホルモン学会学術集会, Nov. 2010.
34. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Yoshio Hayashi and Eiji Tanaka :
Analysis of osteoclast activation in the pathogenesis of rheumatoid arthritis,
58th JADR, Nov. 2010.
35. Hiroyuki Mizuguchi, 玉田 美咲, Naozumi Ishimaru, Yoshiaki Kitamura, Yoshio Hayashi, Noriaki Takeda and Hiroyuki Fukui :
鼻過敏症ラット鼻粘膜におけるヒスタミンシグナルとサイトカインシグナルのクロストーク,
日本薬理学会第118回近畿部会, Nov. 2010.
36. Ritsuko 徳永 律子 Oura, Naozumi Ishimaru, Masahiro Hiasa, Kazuma Matsumoto, Yoshio Hayashi and Eiji Tanaka :
Fasを介した末梢T細胞維持機構の破綻による関節リウマチ発症機序の解明,
第69回日本矯正歯科学会, Sep. 2010.
37. Ritsuko 徳永 律子 Oura, Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki, Eiji Tanaka and Yoshio Hayashi :
Fas分子を介したマクロファージによる末梢T細胞の維持機構,
日本病理学会, Vol.99, No.1, 374, Apr. 2010.
38. Kazuma Matsumoto, Naozumi Ishimaru, Rieko Arakaki, Akiko Yamada, Ritsuko 徳永 律子 Oura, Eiji Tanaka and Yoshio Hayashi :
マウス関節炎モデル樹状細胞のRANKL/Fasシグナルを介した免疫抑制効果,
日本病理学会, Vol.99, No.1, 220, Apr. 2010.
39. Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki and Yoshio Hayashi :
シェーグレン症候群における調節性T細胞の役割,
日本病理学会会誌, Vol.99, No.1, 228, Apr. 2010.
40. Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
Ⅰ型糖尿病モデルマウスにおけるカテプシンL特異的阻害剤を用いた治療効果の検討,
日本病理学会会誌, Vol.99, No.1, 222, Apr. 2010.
41. Kazuma Matsumoto, Naozumi Ishimaru, Rieko Arakaki, Akiko Yamada, Ritsuko 徳永 律子 Oura, Eiji Tanaka and Yoshio Hayashi :
マウス関節炎モデル樹状細胞のRANKL/FASシグナルを介した免疫抑制効果,
日本病理学会会誌, Vol.99, No.1, 220, Apr. 2010.
42. Rieko Arakaki, Naozumi Ishimaru, Akiko Yamada and Yoshio Hayashi :
エストロゲン欠乏依存的に唾液腺に誘導される膵ラ氏島アミロイドポリペプチドの機能とその意義,
日本病理学会会誌, Vol.99, 307, Apr. 2010.
43. Hiroki Iga, Masanori Nakano, Daisuke Hinode, Kazumi Ozaki, Hisahiro Takeuchi, Katsuhiko Yoshimoto and Yoshio Hayashi :
口腔保健学を基軸とした国際的社会福祉教育プログラムの構築に向けて,
平成21年度 全学FD 徳島大学教育カンファレンス, Mar. 2010.
44. 玉田 美咲, Hiroyuki Mizuguchi, Naozumi Ishimaru, Yoshiaki Kitamura, Yoshio Hayashi, Noriaki Takeda and Hiroyuki Fukui :
ラット鼻粘膜におけるヒスタミンとインターロイキン -4 のクロストーク,
日本薬学会第130年会, Mar. 2010.
45. Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
Therapeutic Analysis by Selective Inhibition of Cathepsin L for Autoimmune Diabetes in NOD Mice,
日本免疫学会総会・学術集会, Dec. 2009.
46. Kazuma Matsumoto, Naozumi Ishimaru, Takashi Izawa, Rieko Arakaki, Ritsuko 徳永 律子 Oura, Eiji Tanaka and Yoshio Hayashi :
Immunoregulatory effect via RANKL and Fas signaling of dendritic cells in immurine autoimmune arthritis models,
日本免疫学会総会・学術集会, Dec. 2009.
47. Ritsuko 徳永 律子 Oura, Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki, Takashi Izawa, Kazuma Matsumoto, Eiji Tanaka and Yoshio Hayashi :
Immune Regulation by Macrophages through cross-talk between Fas and NF-B Signaling,
日本免疫学会総会・学術集会, Dec. 2009.
48. Naozumi Ishimaru, Rieko Arakaki, Akiko Yamada, Yousuke Takahama and Yoshio Hayashi :
In situ patrolling of regulatory T cells is essential for protecting organ-specific autoimmunity,
日本免疫学会総会・学術集会, Dec. 2009.
49. Masayuki Kohashi, Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki and Yoshio Hayashi :
Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)causes autoimmunity due to the disruption of Tcell tolerance,
2009日本免疫学会総会・学術集会記録, Vol.39, Dec. 2009.
50. Kazuma Matsumoto, Takashi Izawa, Ritsuko 徳永 律子 Oura, Yoshio Hayashi and Eiji Tanaka :
関節リウマチにおけるRANKL/Fasシグナルを介した骨・軟骨破壊機構の解析,
第68回日本矯正歯科学会学術大会, Nov. 2009.
51. Takeo Iwata, Naozumi Ishimaru, Yoshio Hayashi, Noriko Mizusawa and Katsuhiko Yoshimoto :
脂肪組織におけるYKL-40の役割,
第51回歯科基礎医学会学術大会, Sep. 2009.
52. Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki and Yoshio Hayashi :
Local Toleranceの破綻による臓器特異的自己免疫疾患の発症機序,
日本病理学会会誌, Vol.98, No.1, 249, May 2009.
53. Rieko Arakaki, Naozumi Ishimaru, Akiko Yamada and Yoshio Hayashi :
エストロゲン欠乏によって唾液腺に誘導される樹状細胞の同定とその機能,
日本病理学会会誌, Vol.98, No.1, 365, May 2009.
54. Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
Ⅰ型糖尿病マウスにおけるカテプシンLを介した治療学的解析,
日本病理学会会誌, Vol.98, No.1, 240, May 2009.
55. Yoshio Hayashi :
唾液腺の分子病理学,
日本口腔科学会, Apr. 2009.
56. Takashi Izawa, Naozumi Ishimaru, Rieko Arakaki, Ritsuko 徳永 律子 Oura, Eiji Tanaka and Yoshio Hayashi :
Analysis of RANKL and Fas signaling through NF-kB in dendritic cell activation in murine autoimmune arthritis models,
Proceedings of the Japanese Society for Immunology, Vol.38, 176, Dec. 2008.
57. Rieko Arakaki, Naozumi Ishimaru, Akiko Yamada and Yoshio Hayashi :
Identification and functional analysis of CD11c+B220+ dendritic cells induced by estrogen deficiency in salivary glands .,
第38回日本免疫学会総会・学術集会, Vol.38, 97, Dec. 2008.
58. Naozumi Ishimaru, Kohashi Masayuki, Akiko Yamada, Rieko Arakaki and Yoshio Hayashi :
Neonatal exposure to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)causes autoimmunity due to the disruption of T cell tolerance,
第38回日本免疫学会総会・学術集会, Vol.38, 97, Dec. 2008.
59. Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
Therapeutic analysis for autoimmune diabetes in NOD mice using specific inhibitor for cathepsin L,
第38回日本免疫学会総会・学術集会, Vol.38, 93, Dec. 2008.
60. Takashi Izawa, Yoshio Hayashi and Eiji Tanaka :
Analysis for mechanism of articular bone and cartilage destruction via RANKL signal in rheumatoid arthritis,
第67回日本矯正歯科学会学術大会, Sep. 2008.
61. Hiroyoshi Hosokawa, Kazuhito Satomura, Keiko Kudoh, Seiko Tatehara, Reiko Tokuyama, Hideyuki Takano, Masaru Nagayama, Naozumi Ishimaru and Yoshio Hayashi :
頬粘膜に発生した血管筋腫の1例,
Journal of The Japanese Stomatological Society, Vol.57, No.3, 348, Jul. 2008.
62. Hiroyoshi Hosokawa, Kazuhito Satomura, Keiko Kudoh, Seiko Tatehara, Reiko Tokuyama, 高野 栄之, Naozumi Ishimaru, Yoshio Hayashi and Masaru Nagayama :
頬粘膜に発生した血管筋腫の1例,
Journal of The Japanese Stomatological Society, Vol.57, No.3, 348, Jul. 2008.
63. Hoang Nam Tran, Takashi Sakai, Salah M. El-Sayed, Li Liu, Rika Sakai, Naozumi Ishimaru, Yoshio Hayashi, Ryuji Kaji and Kiyoshi Fukui :
新規アポトーシス制御分子ヌクリングはNF-κB の制御に関与する,
第49回日本生化学会中国四国支部例会, May 2008.
64. Naozumi Ishimaru and Yoshio Hayashi :
自己免疫病と性差,
第97回日本病理学会総会, Vol.97, No.1, 170, May 2008.
65. Rieko Arakaki, Naozumi Ishimaru, Akiko Yamada and Yoshio Hayashi :
エストロゲン欠乏による外分泌腺上皮クラスⅡ発現の誘導メカニズム,
第97回日本病理学会総会, Vol.97, No.1, 322, May 2008.
66. Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
Ⅰ型糖尿病モデルマウスにおけるカテプシンL阻害剤を用いた治療学的解析,
第97回日本病理学会総会, Vol.97, No.1, 266, May 2008.
67. Takashi Sakai, HoangNam Tran, Li Liu, Xichuan Teng, Naozumi Ishimaru, Rika Sakai, Nobuya Sano, Ryuji Kaji, Yoshio Hayashi and Kiyoshi Fukui :
Nucling is essential for the maintenance of Kupffer cells related to tumorgenesis in liver,
The 30th Annual Meetings of the Molecular Biology Society of Japan/The 80th Annual Meeting of the Japanese Biochemical Society, Dec. 2007.
68. Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
IFN-γ-producing epithelial cells links autoimmune exocrinopathy resembling SS in RbAp48 TG mice,
第37回日本免疫学会総会・学術集会, Vol.37, 263, Nov. 2007.
69. Rieko Arakaki, Naozumi Ishimaru, Akiko Yamada and Yoshio Hayashi :
Role of estrogen deficiency for aberrant MHC class 2 expression in the exocring gland cells,
第37回日本免疫学会総会・学術集会, Vol.37, 265, Nov. 2007.
70. Akiko Yamada, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
T cell functions with aging in NF-kB1-deficient mice,
第37回日本免疫学会総会・学術集会, Vol.37, 174, Nov. 2007.
71. Takashi Izawa, Naozumi Ishimaru, Masayuki Kohashi, Rieko Arakaki and Yoshio Hayashi :
Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance,
第37回日本免疫学会総会・学術集会 ワークショップ, Vol.37, Nov. 2007.
72. Miho Okuno, Naozumi Ishimaru, Takashi Izawa, Rieko Arakaki, Akiko Yamada and Yoshio Hayashi :
Analysis of NF-kB in T cell activation in murine autoimmune model,
第37回日本免疫学会総会・学術集会, Vol.37, 119, Nov. 2007.
73. Masayuki Kohashi, Naozumi Ishimaru, Akiko Yamada, Rieko Arakaki, Jun Kanno and Yoshio Hayashi :
The effect of TCDD administration on murine model for Sjogren's syndrome,
第37回日本免疫学会総会・学術集会, Vol.37, 116, Nov. 2007.
74. Takashi Izawa, Yoshio Hayashi and Keiji Moriyama :
RANKLシグナルを介した関節炎モデルマウス樹状細胞の機能解析,
第66回日本矯正歯科学会大会 学術展示, Sep. 2007.
75. Takashi Izawa, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
関節リウマチモデルMRL/lprマウス樹状細胞の機能解析,
第6回四国免疫フォーラム 一般演題, Jul. 2007.
76. Hiroyoshi Hosokawa, Kazuhito Satomura, Yukihiro Momota, Keiko Kudoh, Seiko Tatehara, Reiko Tokuyama, Hideyuki Takano, Naozumi Ishimaru, Yoshio Hayashi, Masaru Nagayama and 第17回日本口腔粘膜学会 :
口腔白板症の臨床病理学的検討,
第17回日本口腔粘膜学会 2007.7.5∼7.6,東京, Jul. 2007.
77. Takashi Sakai, Li Liu, Xichuan Teng, Naozumi Ishimaru, Rika Sakai, Nobuya Sano, Ryuji Kaji, Hoang Nam Tran, Yoshio Hayashi and Kiyoshi Fukui :
新規アポトーシス制御分子ヌクリングの肝癌発症機構における役割の解明,
第48回日本生化学会中国四国支部例会, May 2007.
78. Kohashi Masayuki, Rieko Arakaki, Naozumi Ishimaru and Yoshio Hayashi :
シェーグレン症候群モデルマウスにおけるレバミピドの病態抑制効果,
第96回日本病理学会総会, Vol.96, No.1, 295, Mar. 2007.
79. Rieko Arakaki, Naozumi Ishimaru, Kohashi Masayuki and Yoshio Hayashi :
シェーグレン症候群類似RbAp48遺伝子導入マウスにおける病態形成の解析,
第96回日本病理学会総会, Vol.96, No.1, 295, Mar. 2007.
80. Rieko Arakaki, Naozumi Ishimaru, Masayuki Kohashi and Yoshio Hayashi :
シェーグレン症候群類似RbAp48遺伝子導入マウスにおける病態形成の解析,
日本病理学会会誌, Vol.96, No.1, Mar. 2007.
81. Masayuki Kohashi, Rieko Arakaki, Naozumi Ishimaru and Yoshio Hayashi :
シェーグレン症候群モデルマウスにおけるレバミピドの病態抑制効果,
日本病理学会会誌, Vol.96, No.1, Mar. 2007.
82. Naozumi Ishimaru, 高木 篤也, 菅野 純 and Yoshio Hayashi :
新生仔マウスへのダイオキシン投与による免疫系への影響,
日本病理学会会誌, Vol.96, No.1, Mar. 2007.
83. Naozumi Ishimaru, 高木 篤也, 菅野 純 and Yoshio Hayashi :
新生仔マウスへのダイオキシン投与による免疫系への影響,
第96回日本病理学会総会, Vol.96, No.1, 224, Mar. 2007.
84. Yoshio Hayashi :
新生児マウスへのダイオキシン投与による免疫系への影響,
第17回環境ホルモン学会(日本内分泌撹乱化学物質学会), Feb. 2007.
85. Takashi Izawa, Naozumi Ishimaru, Rieko Arakaki, Keiji Moriyama and Yoshio Hayashi :
Immunoregulatory role of RANKL-stimulated dendritic cells on autoimmune arthritis in MRL/lpr mice,
第36回日本免疫学会総会・学術集会 ワークショップ, Vol.36, 284, Dec. 2006.
86. Naozumi Ishimaru, Masayuki Kohashi, Rieko Arakaki, Hidehiro Kishimoto and Yoshio Hayashi :
NF-κB2 pathway in T cell activation for autoimmunity,
日本免疫学会総会・学術集会記録, Vol.36, Dec. 2006.
87. Masayuki Kohashi, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
Effect of rebamipide administration on Sjogren's syndrome mouse model,
日本免疫学会総会・学術集会記録, Vol.36, Dec. 2006.
88. Rieko Arakaki, Naozumi Ishimaru and Yoshio Hayashi :
Development of exocrinopathy resembling Sjogren's syndrome in RbAp48 transgenic mice,
日本免疫学会総会・学術集会記録, Vol.36, Dec. 2006.
89. Naozumi Ishimaru and Yoshio Hayashi :
NF-kBシグナルを介した自己免疫疾患の発症機序,
第54回NPO法人日本口腔科学会, Nov. 2006.
90. 大嶋 淳, Takashi Izawa, Naozumi Ishimaru, Yoshio Hayashi and Keiji Moriyama :
関節炎モデルマウスを用いた樹状細胞移入による関節リウマチ病態の修飾,
第65回日本矯正歯科学会大会 学術展示, 217, Sep. 2006.
91. Naozumi Ishimaru, Keisuke Izumi and Yoshio Hayashi :
LECラットに発生する炎症性腸疾患の解析,
第3回日本病理学会カンファレンス ポスター発表, Aug. 2006.
92. Yoshio Hayashi, Naozumi Ishimaru and Nobuhiko Katunuma :
Cathepsin L-inhibitor Prevents Proinsulin Peptide Processing and Autoimmune Diabetes in Nonobetic(NOD)Mice,
Satellite Meeting of the 20th IUBMB International Congress and 11th FAOBMB Congress, Jun. 2006.
93. Naozumi Ishimaru and Yoshio Hayashi :
In Vivo Role of NF-κB-inducing Kinase for T Cell Activation,
Satellite Meeting of the 20th IUBMB International Congress and 11th FAOBMB Congress, Jun. 2006.
94. Rieko Arakaki, Naozumi Ishimaru and Yoshio Hayashi :
臓器特異的アポトーシスと自己免疫,
第5回四国免疫フォーラム 一般演題, Jun. 2006.
95. Naozumi Ishimaru, Hidehiro Kishimoto, Yoshio Hayashi and Sprent Jonathan :
T細胞活性化機構におけるNF-kB2経路の役割,
第16回Kyoto T Cell Conference(KTCC) ワークショップ, Jun. 2006.
96. Naozumi Ishimaru, Keisuke Izumi and Yoshio Hayashi :
LECラットに発生する炎症性腸疾患の解析,
第16回LECラット研究会大会, May 2006.
97. Fumie Omotehara, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
シェーグレン症候群加齢モデルマウスにおける間質性肺病変の解析,
第95回日本病理学会総会 一般口演, Vol.95, No.1, 211, May 2006.
98. Naozumi Ishimaru, Rieko Arakaki, Fumie Omotehara and Yoshio Hayashi :
NF-kBシグナルを介した自己免疫疾患の発症機序,
第95回日本病理学会総会 一般口演, Vol.95, No.1, 211, May 2006.
99. Katsushi Miyazaki, Noriaki Takeda, Naozumi Ishimaru and Yoshio Hayashi :
原発性シェーグレン症候群における自己抗原α-フォドリンの生体内での役割の解析,
第107回日本耳鼻咽喉科学会総会, May 2006.
100. Naozumi Ishimaru, Hidehiro Kishimoto, Jonathan Sprent and Yoshio Hayashi :
Immunoregulation by NF-kB for T cell activation in autoimmune disease,
日本免役学会総会·学術集会記録, Vol.35, 275, Dec. 2005.
101. Naozumi Ishimaru, Hidehiro Kishimoto, Jonathan Sprent and Yoshio Hayashi :
Immunoregulation by NF-kB for T cell activation in autoimmune disease,
第35回日本免疫学会総会・学術集会 ワークショップ, Vol.35, 275, Dec. 2005.
102. Takashi Izawa, Naozumi Ishimaru, Fumie Omotehara, Rieko Arakaki, 大嶋 淳, Keiji Moriyama and Yoshio Hayashi :
RANKL刺激活性化DCを介したMRL/lprマウス関節炎の病態修飾,
第35回日本免疫学会総会・学術集会 ワークショップ, Vol.35, 249, Dec. 2005.
103. Megumi Watanabe, Naozumi Ishimaru, Rieko Arakaki, Fumie Omotehara and Yoshio Hayashi :
Niアレルギーにおける樹状細胞及びT細胞の活性化機構,
日本免役学会総会·学術集会記録, Vol.35, 140, Dec. 2005.
104. Megumi Watanabe, Naozumi Ishimaru, Rieko Arakaki, Fumie Omotehara and Yoshio Hayashi :
Niアレルギーにおける樹状細胞及びT細胞の活性化機構,
第35回日本免疫学会総会・学術集会 ワークショップ, Vol.35, 140, Dec. 2005.
105. Fumie Omotehara, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
シェーグレン症候群加齢モデルマウスにおける間質性肺病変の解析,
日本免役学会総会·学術集会記録, Vol.35, 36, Dec. 2005.
106. 小橋 真之, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
シェーグレン症候群モデルマウスにおけるレバミピドの治療効果の検討,
日本免役学会総会·学術集会記録, Vol.35, 33, Dec. 2005.
107. Fumie Omotehara, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
シェーグレン症候群加齢モデルマウスにおける間質性肺病変の解析,
第35回日本免疫学会総会・学術集会 ワークショップ, Vol.35, 36, Dec. 2005.
108. 小橋 真之, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
シェーグレン症候群モデルマウスにおけるレバミピドの治療効果の検討,
第35回日本免疫学会総会・学術集会 ワークショップ, Vol.35, 33, Dec. 2005.
109. Chieko Sugawara, Hirokazu Iwasaki, Keiko Kudoh, Masaru Nagayama and Yoshio Hayashi :
舌悪性腫瘍により内頸静脈腫瘍塞栓をきたした症例の画像所見,
Japanese Journal of Oral & Maxillofacial Surgery, Vol.51, 94, Oct. 2005.
110. 大嶋 淳, Takashi Izawa, Yoshio Hayashi and Keiji Moriyama :
樹状細胞移入によるMRL/lprマウス関節リウマチ病態の修飾,
第64回 日本矯正歯科学会大会 学術展示, Oct. 2005.
111. Yoshio Hayashi :
シェーグレン症候群発症の分子機序,
第二回日本病理学会カンファレンス 招待講演, 22, Jul. 2005.
112. 大嶋 淳, Takashi Izawa, Naozumi Ishimaru, Fumie Omotehara, Rieko Arakaki, Keiji Moriyama and Yoshio Hayashi :
樹状細胞移入によるMRL/lprマウス関節リウマチ病態の修飾,
第2回日本病理学会カンファレンス ポスター発表, 46, Jul. 2005.
113. Fumie Omotehara, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
RbAp48トランスジェニックマウスを用いたシェーグレン症候群新規モデルの作成,
第2回日本病理学会カンファレンス ポスター発表, 48, Jul. 2005.
114. Naozumi Ishimaru and Yoshio Hayashi :
自己免疫疾患におけるNF-kBを介したT細胞活性化機構の解析,
第二回日本病理学会カンファレンス ポスター発表, 38, Jul. 2005.
115. Naozumi Ishimaru and Yoshio Hayashi :
T細胞活性化機構におけるRelBの役割,
第4回四国免疫フォーラム, Jun. 2005.
116. Takashi Izawa, Yoshio Hayashi and Keiji Moriyama :
関節リウマチ自然発症モデルマウスを用いた関節骨破壊機構の解析,
第59回日本口腔科学会総会 ミニシンポジウム 口演発表, Apr. 2005.
117. Naozumi Ishimaru, Rieko Arakaki, Fumie Omotehara and Yoshio Hayashi :
自己免疫疾患におけるNF-kBを介したT細胞活性化機構の解析,
第94回日本病理学会総会 一般口演, Vol.94, No.1, 224, Apr. 2005.
118. Rieko Arakaki, Naozumi Ishimaru, Fumie Omotehara and Yoshio Hayashi :
RbAp48遺伝子導入マウスにみられるシェーグレン症候群類似病変の解析,
第94回日本病理学会総会 一般口演, Vol.94, No.1, 206, Apr. 2005.
119. Fumie Omotehara, Naozumi Ishimaru, Rieko Arakaki, 大嶋 淳 and Yoshio Hayashi :
シェーグレン症候群における自己抗原120kDa α-フォドリンの意義,
第94回日本病理学会総会 一般口演, Vol.94, No.1, 206, Apr. 2005.
120. Jun Oshima, Naozumi Ishimaru, Rieko Arakaki, Fumie Omotehara and Yoshio Hayashi :
RANKL刺激樹状細胞移入によるMRL/lprマウス関節リウマチ病変の解析,
第94回日本病理学会総会 一般口演, Vol.94, No.1, 197, Apr. 2005.
121. Yoshio Hayashi :
シェーグレン症候群発症の分子基盤,
第94回日本病理学会総会 ワークショップ, Vol.94, No.1, 159, Apr. 2005.
122. Yukihiro Momota, Hiroaki Nakanishi, Seiko Tatehara, Tetsuya Yuasa, Hideyuki Takano, 南口 知穂, Kazuhito Satomura, Yoshio Hayashi and 長山 勝 :
TS-1を投与した舌癌の2例,
第3回中四国口腔癌研究会, Oct. 2004.
123. Yoshio Hayashi :
Autoimmunity and aging,Aging and Immunity,
第27回日本基礎老化学会国際シンポジウム, Jun. 2004.
124. Takashi Izawa, Naozumi Ishimaru, Rieko Arakaki and Yoshio Hayashi :
RANKL刺激樹状細胞移入によるMRL/lprマウス自己免疫性関節炎の病態修飾,
第33回日本免疫学会総会・学術集会 ワークショップ, Dec. 2003.
125. Takashi Izawa, Yoshio Hayashi and Keiji Moriyama :
RANKL刺激樹状細胞移入によるMRL/lprマウス自己免疫性関節炎の病態修飾,
第62回 日本矯正歯科学会 学術展示, Oct. 2003.
126. Yoshio Hayashi :
自己免疫疾患の分子病理,
第2回日本口腔科学会シンポジウム, Aug. 2003.
127. Takashi Izawa, Keiji Moriyama and Yoshio Hayashi :
RANKL刺激樹状細胞移入によるMRL/lprマウス自己免疫性関節炎の病態修飾,
第21回 日本骨代謝学会 ポスター発表, Jun. 2003.
128. Yoshio Hayashi :
シェーグレン症候群の病因と治療戦略,
日本リウマチ学会第47回総会シンポジウム, Apr. 2003.
129. Takashi Izawa, Keiji Moriyama and Yoshio Hayashi :
RANKL刺激による活性化樹状細胞を用いたMRL/lprマウス関節病変の増悪,
第20回 日本骨代謝学会 口演発表, Jul. 2002.
130. Yoshio Hayashi :
シェーグレン症候群の新規治療戦略,
日本口腔粘膜学会第12回総会シンポジウム, Jul. 2002.
131. Yoshio Hayashi :
シェーグレン症候群の病因と治療戦略,
日本口腔科学会第49回特別講演, Nov. 2001.
132. Yoshio Hayashi :
マウスモデルを用いた自己抗原の研究,
臨床免疫学会第28回総会ワークショップ, Sep. 2000.
133. Yoshio Hayashi :
動物モデルとヒトの疾患:シェーグレン症候群疾患モデルについて,
日本実験動物学会総会第47回特別講演, May 2000.
134. Yoshio Hayashi :
シェーグレン症候群自己抗原アルファーフオドリンの病原性,
日本リウマチ学会第44回総会シンポジウム, May 2000.
135. Yoshio Hayashi :
シェーグレン症候群モデルマウスにおける老化とアポートシス,
日本病理学会第89回総会ワークショップ, Apr. 2000.
136. Yoshiko Noda, Kenji Fujisawa, 小積 麻衣子, Nobuyuki Kamata, Masaru Nagayama and Yoshio Hayashi :
下顎骨に発生した形質細胞腫の1例,
第29回日本口腔外科学会中国四国地方会, 2000.
137. Reiko Tokuyama, Hiroaki Nakanishi, Kenji Fujisawa, Yoshio Hayashi and Masaru Nagayama :
長期経過をたどった口腔粘膜多発癌の1例,
第49回日本口腔科学会中国・四国地方部会, 2000.
138. Yoshio Hayashi :
シェーグレン症候群自己抗原アルファーフオドリンの病因的意義,
日本リウマチ学会第43回総会シンポジウム, Jun. 1999.
139. Yoshio Hayashi :
シェーグレン症候群の病理,
日本病理学会第88回総会宿題報告, Apr. 1999.
140. Yoshio Hayashi :
シェーグレン症候群における自己抗原アルファーフオドリンの性状とその意義,
第5回自己抗体と自己抗原シンポジウム, Feb. 1998.
141. Yoshio Hayashi :
120K alpha-fodrin as a candidate autoantigen in primary Sjogren`s syndrome,
日本免疫学会第26回総会国際シンポジウム, Nov. 1996.
142. Yoshio Hayashi and 羽地 則雄 :
シェーグレン症候群モデルマウスにおける臓器特異的自己抗原の解析,
日本リウマチ学会第40回総会シンポジウム, May 1996.
143. 濱口 幸子, Katsuhiko Yoshimoto, Toshiaki Sano, Hiroyuki Iwahana, Yoshio Hayashi and Mitsuo Itakura :
IFN-γを膵ランゲルハンス島(膵ラ島)A細胞で発現するトランスジェニックマウス(IFN-γ Tg)における耐糖能異常の出現,
第38回日本糖尿病学会年次学術集会(大宮), May 1995.
144. Maki Moritani, Katsuhiko Yoshimoto, 田代 文, 橋本 力, 宮崎 純一, Hiroyuki Iwahana, Yoshio Hayashi, Toshiaki Sano and Mitsuo Itakura :
膵ランゲルハンス島(膵島)A細胞に発現させたIL-10による膵島炎促進の系統依存性,
第24回日本免疫学会総会・学術集会(京都), Nov. 1994.
145. 濱口 幸子, Katsuhiko Yoshimoto, 小海 康夫, Toshiaki Sano, Hiroyuki Iwahana, Yoshio Hayashi and Mitsuo Itakura :
IFNγを膵ランゲルハンス島(膵ラ島)A細胞で発現するトランスジェニックマウス(IFNγTg)における耐糖能異常の出現,
第67回日本内分泌学会秋期学術大会(広島), Nov. 1994.
146. Yoshio Hayashi :
シェ-グレン症候群疾患モデルのSCIDマウスへの移入,
日本炎症学会第16回総会シンポジウム, Jul. 1994.
147. Katsuhiko Yoshimoto, Maki Moritani, 田代 文, 橋本 力, 宮崎 純一, Setsuko Ii, Eiji Kudo, Hiroyuki Iwahana, Yoshio Hayashi, Toshiaki Sano and Mitsuo Itakura :
膵ランゲルハンス島A細胞にIL-10を発現させたトランスジェニックNODマウスにおける糖尿病発症の促進,
第67回日本内分泌学会学術総会(長崎), Jun. 1994.
148. Maki Moritani, Katsuhiko Yoshimoto, 田代 文, 橋本 力, 宮崎 純一, Setsuko Ii, Eiji Kudo, Hiroyuki Iwahana, Yoshio Hayashi, Toshiaki Sano and Mitsuo Itakura :
(膵ランゲルハンス島(膵ラ島)A細胞にIL-10を発現させたトランスジェニックマウス(Tg)における糖尿病発症の促進,
第37回日本糖尿病学会年次学術集会(徳島), May 1994.
149. Mitsuo Itakura, Maki Moritani, Katsuhiko Yoshimoto, 田代 文, 橋本 力, 宮崎 純一, Setsuko Ii, Eiji Kudo, Hiroyuki Iwahana, Yoshio Hayashi and Toshiaki Sano :
(ワークショップ)「トランスジェニック動物の糖尿病学への貢献」,IL-10を膵ラ氏島A細胞で発現するNODトランスジェニックマウス,
第37回日本糖尿病学会年次学術集会(徳島), May 1994.
150. Maki Moritani, Katsuhiko Yoshimoto, 田代 文, 橋本 力, 宮崎 純一, Setsuko Ii, Eiji Kudo, 岩花 弘之, Yoshio Hayashi, Toshiaki Sano and Mitsuo Itakura :
膵ランゲルハンス島(膵ラ島)A細胞からIL-10を分泌するNODトランスジェニックマウス(Tg)における膵ラ島B細胞の自己免疫性破壊の促進,
第23回日本免疫学会総会・学術集会(仙台), Nov. 1993.
151. Yoshio Hayashi :
シェーグレン症候群実験モデルマウスによる病因解析の試み,
日本病理学会第38回秋期総会A演説, Nov. 1992.
152. 林 義典, 城野 良三, Yoshihiro Takegawa, Mitsunobu Sato, 梁川 哲夫 and Yoshio Hayashi :
骨破壊を伴った上顎洞真菌症の一例,
日本医学放射線学会第63回中国・四国地方会(岡山), Nov. 1984.
153. Yoshio Hayashi, Mitsunobu Sato, 吉本 奈奈代, Hideo Yoshida, 梁川 哲雄, 由良 義明 and Toshinobu Nishida :
頭頸部癌患者末梢血リンパ球サブセットの異常,
Journal of Clinical and Experimental Medicine, Vol.128, No.8, 507-508, 1984.
154. Yoshio Hayashi, Toshinobu Nishida, Tetsuo Yanagawa, Hideo Yoshida and Mitsunobu Sato :
Expression of carcinoemryonic antigen in the neoplastic cells originated from human salivary gland,
Tissue Culture in Dentistry, Vol.19, 27-28, 1982.
155. Yoshio Hayashi, Toshinobu Nishida, Toshiharu Nitta, Tetsuo Yanagawa, Hideo Yoshida and Mitsunobu Sato :
Peripheral k lymphocytes as an immunologic parameter in the patients with oral cancer,
Tissure Culture in Dentistry, Vol.19, 25-26, 1982.

Et cetera, Workshop:

1. Naozumi Ishimaru and Yoshio Hayashi :
臓器特異的アポトーシスとシェーグレン症候群,
第15回日本シェーグレン症候群研究会, Sep. 2006.
2. Yoshio Hayashi, Rieko Arakaki and Hitomi Fukui :
Experimental approach for Sjögren s syndrome,
細胞, Vol.36, No.6, 30-33, Jun. 2004.

Report:

1. Masayuki Shibuya, Hiroshi Kido, Yoshio Hayashi, Hisao Nemoto, Shigeki Sano, Koji Yasutomo, Hiroyuki Azuma, Yasuhiko Nishioka, Junji Terao, Takeshi Nikawa, Hiroaki Misawa, Shigeki Matsuo, Yoshinobu Baba, Kozo Matsumoto, Hirokazu Miyoshi and Saburo Sone :
徳島大学先端医療開発研究センター設置準備室成果報告書,
Dec. 2002.

Patent:

1. Yoshio Hayashi : Methods for Treating Autoimmune Diseases and Screening Method for Preventive or Therapeutic Agent for the Same., US2005/0026824A1, .

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 抗原特異的調節性T細胞による細胞免疫療法の開発 (Project/Area Number: 22659341 )
  • 自己抗原に依存した未知の調節性T細胞に関する探索的研究 (Project/Area Number: 21659434 )
  • Immunotherapeutic analysis using newly established murine models for Sjogren' s syndrome (Project/Area Number: 21249090 )
  • Molecular analysis of pathogenesis on Sjogren's syndrome and its application of new diagnosis and therapy (Project/Area Number: 17109016 )
  • Fasリガンド分子制御によるシェーグレン症候群治療法の研究開発 (Project/Area Number: 15659094 )
  • Mechanism of bone destruction due to Rheumatoid Arthritis in the fields of Osteoimmunology (Project/Area Number: 15390637 )
  • 歯科用金属の溶出と局所免疫クロストークの相関性に関する研究 (Project/Area Number: 14657504 )
  • シェーグレン症候群診断基準査定調査の企画 (Project/Area Number: 13897017 )
  • カスパーゼ活性阻害によるシェーグレン症候群制御法の開発 (Project/Area Number: 13877305 )
  • SCREENING OF SALIVARY GLAND PROTEASE WHICH SPECIFICALLY CLEAVAGES SJOGREEN'S SYNDROME RELATED AUTOANTIGEN a-PODRIN FRAGMENT (Project/Area Number: 13670218 )
  • Development of disease-specific diagnosis and immunotherapy for Sjogren's syndrome (Project/Area Number: 12557022 )
  • Analysis of the mechanism of membranous proteolysis and the immunoregulation for Sjogren's syndrome (Project/Area Number: 12307040 )
  • A study of molecular pathology in experimental Sjogren's syndrome in mice (Project/Area Number: 08407057 )
  • Experimental study of the therapeutic effect of synthetic peptide for Sjogren's syndrome (Project/Area Number: 07557121 )
  • Experimental study of pathogenesis and therapeutic effect for Sjogren's syndrome (Project/Area Number: 05557079 )
  • Establishment of animal model for Sjogren's syndrome in mutant mice (Project/Area Number: 03454422 )
  • 唾液腺ミュ-タントマウスに見られる形質発現調節異常の解析 (Project/Area Number: 01571007 )
  • 老化に伴う臓器局在性自己免疫疾患の発症機序に関する実験的研究 (Project/Area Number: 63570171 )
  • Immune Responses Associated with Killer-Lymphocyte Population in Oral Cancer and their Therapeutic Significance (Project/Area Number: 61440083 )
  • Search by Researcher Number (00127854)