徳島大学 / 教育研究者総覧 --- 宮本洋二

個人のホームページ

https://researchmap.jp/read0017487 (researchmap)

専門分野

○	歯学 (Dentistry)

研究テーマ

○

著書・論文

著書:

1.	Youji Miyamoto and Masayuki Fukuda : Application of biomaterials for cleft lip and palate surgery, Quintessence,
2.	工藤景子, 宮本洋二 : よくわかる口腔インプラント学, 医歯薬出版株式会社, 2023年2月.
3.	宮本洋二 : コラム1「インプラントと非可動性角化粘膜」, 医歯薬出版株式会社, 2023年2月.
4.	工藤景子, 宮本洋二 : 第8章手術および上部構造に関連する併発症とその対応，1「手術中の併発症」, 医歯薬出版株式会社, 2023年2月.
5.	栗尾奈愛, 宮本洋二 : 第5章口腔インプラント学のための基礎医学，Ⅲ外科手術，1「インプラント手術の準備と感染対策」, 医歯薬出版株式会社, 2023年2月.
6.	石川邦夫, 宮本洋二 : 第2章口腔インプラント学のための基礎医学，Ⅲ材料学，3骨補填材と遮断膜，1)「骨補填材」, 医歯薬出版株式会社, 2023年2月.
7.	山村佳子, 宮本洋二 : 周術期口腔機能管理に実際がよくわかる本, --- 第2章 4. 臓器移植手術と口腔管理 ---, クインテッセンス出版株式会社, 東京, 2020年9月.
8.	宮本洋二 : 第5章 1-Ⅲ 「歯根尖(端)切除術」, 医歯薬出版, 2017年9月.
9.	宮本洋二, 永井宏和 : 第5章 1-Ⅱ 「抜歯述」, 医歯薬出版, 2017年9月.
10.	宮本洋二 : 第5章 1-Ⅰ 「歯・歯周組織とその周囲の解剖」, 医歯薬出版, 2017年9月.
11.	日本口腔ケア学会編, 宮本洋二, 福田雅幸 : 歯ぎしりがひどい高齢者への対応, 永末書店, 2017年4月.
12.	宮本洋二 : インプラント治療後に腎疾患になったら?，第3章:高齢者にインプラント治療を行った後で疾病が発症したら?, 2014年6月.
13.	宮本洋二 : 医科への照会の仕方，Chapter16:医科への照会の仕方, 2014年5月.
14.	宮本洋二 : 抗凝固療法・抗血小板療法時の歯科治療，Chapter5:血液疾患, 2014年5月.
15.	M. Fukuda and Youji Miyamoto : Care for elderly patients with serious bruxism, Quintessence Publishing CO.,Ltd., Tokyo, 2011.
16.	浜田賢一, 宮本洋二, 淺岡憲三 : 骨修復材, 医歯薬出版株式会社, 東京, 2006年5月.
17.	宮本洋二, 福田雅幸 : うがいの一般的な方法として，誤っているものはどれか, 日総研出版, 2006年.
18.	Youji Miyamoto, Kunio Ishikawa, Shigeki Matsuya and Kenji Kawate : In Encyclopedia of Comprehensive structural integrity, 2003.

学術論文(審査論文):

1.	Naoyuki Fukuda, Natsumi Takamaru, Kazuya Akita, Keiko Kudoh, Ishikawa Kunio and Youji Miyamoto : Application and evaluation of carbonate apatite granules for mandibular bone defect reconstruction after jawbone cyst enucleation-a retrospective case series, Oral and Maxillofacial Surgery, Vol.29, No.1, 14, 2024. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10006-024-01306-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 39572439 ● Search Scopus @ Elsevier (PMID): 39572439 ● Search Scopus @ Elsevier (DOI): 10.1007/s10006-024-01306-2 (DOI: 10.1007/s10006-024-01306-2, PubMed: 39572439)
2.	Kazuya Akita, Naoyuki Fukuda, Natsumi Takamaru, Keiko Kudoh, Ishikawa Kunio and Youji Miyamoto : Fabrication of a carbonate apatite granules sponge as a new bone substitute and its histological evaluation at rat calvarial bone defects, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2024. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ajoms.2024.05.004 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajoms.2024.05.004 (DOI: 10.1016/j.ajoms.2024.05.004)
3.	工藤隆治, 宮本洋二 : 片側頸部を標的とした強度変調回転照射における線量制約の検討, 歯科放射線, Vol.63, No.2, 47-53, 2024年. (キーワード) 片側 / 頸部 / 強度変調回転照射 / 線量制約 (徳島大学機関リポジトリ) ● Metadata: 119163 (出版サイトへのリンク) ● Publication site (DOI): 10.11242/dentalradiology.63.47 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390862623773836544 ● Search Scopus @ Elsevier (DOI): 10.11242/dentalradiology.63.47 (徳島大学機関リポジトリ: 119163, DOI: 10.11242/dentalradiology.63.47, CiNii: 1390862623773836544)
4.	田中茉里子, 堀内信也, 日浅雅博, 渡邉佳一郎, 岩浅亮彦, 髙丸菜都美, 永井宏和, 宮本洋二, 田中栄二 : 術後に顎関節に疼痛を訴えた顎偏位を伴う骨格性上顎前突症例, 中·四国矯正歯科学会雑誌, Vol.35, No.1, 77-86, 2023年.
5.	Akira Takahashi, Kumiko Kamada, Naoyuki Fukuda, Keiko Kudoh, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Analysis of the sublingual artery using contrast-enhanced computed tomography, Clinical Implant Dentistry and Related Research, Vol.25, No.3, 532-539, 2023. (要約) This in vivo study aimed to clarify the position of the sublingual artery (SLA) relative to the mandibular bone and to infer the potential risk for injury during dental implant surgery. Contrast-enhanced computed tomography images of the mouth of 50 edentulous patients (100 sides) treated at Tokushima University Hospital were reviewed. Curved planar reconstructed images perpendicular to the alveolar ridge were processed and classified into molar, premolar, canine, and incisor regions. The SLA and its branches were identified, and the distance from the mandible to the SLA was measured. The SLA was located close to the mandible (<2 mm) in the molar, premolar, canine, and incisor segments in 12.0% (95% confidence interval 5.6%-18.4%), 20.6% (12.6%-28.7%), 30.5% (21.3%-39.8%), and 41.8% (28.8%-54.9%) cases, respectively. The SLA was located within ±3 mm craniocaudally to the upper wall of the mandibular canal in the molar and premolar regions in 50% of cases and within ±5 mm craniocaudally to the mylohyoid ridge in the canine and incisor regions in the other cases, with no sex or age-related differences. The vertical distance from the alveolar ridge to the SLA was influenced by sex and age owing to alveolar resorption, indicating that the alveolar ridge is not a reliable reference for predicting SLA position. As the risk of SLA injury always exist during dental implant placement and there is no way to confirm the SLA pathways in a patient, clinicians must avoid injuring the sublingual soft tissue. (キーワード) Dental Implants / Mandible / Alveolar Process / Tomography, X-Ray Computed / Cone-Beam Computed Tomography / Arteries (出版サイトへのリンク) ● Publication site (DOI): 10.1111/cid.13197 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36896477 ● Search Scopus @ Elsevier (PMID): 36896477 ● Search Scopus @ Elsevier (DOI): 10.1111/cid.13197 (DOI: 10.1111/cid.13197, PubMed: 36896477)
6.	Atsushi Uesugi, Fumihiko Tsushima, Youji Miyamoto and Hiroyuki Harada : Pollen food allergy syndrome caused by Japanese radish: A case report, Indian Journal of Dermatology, Vol.68, No.1, 123, 2023. (要約) Pollen food allergy syndrome (PFAS) is a food allergy that manifests as hypersensitivity symptoms of the oropharyngeal mucosa on ingesting specific foods, and findings resemble herpetic gingivostomatitis. Few reports of PFAS caused by consuming radishes are found in the literature. A 31-year-old man presented to our department with stomatitis and pharyngeal pain. He had no history of allergies. Herpetic gingivostomatitis was suspected. He was admitted to the emergency room a few days later complaining of oral and epigastric pain. Symptoms were similar to those reported previously. He reported frequently consuming raw Japanese radish ( L.) which gave rise to his symptoms. Japanese radish was suspected as the allergen. The skin-prick test confirmed the diagnosis of PFAS. PFAS can be diagnosed easily once the food-causing symptoms are identified. Upon encountering widespread erosion in the oral cavity, it is essential to consider PFAS as the possible cause. (キーワード) herpetic gingivostomatitis / Japanese radish / pollen food allergy syndrome / Raphans sativus L. / skin prick test (出版サイトへのリンク) ● Publication site (DOI): 10.4103/ijd.ijd_405_22 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37151264 ● Search Scopus @ Elsevier (PMID): 37151264 ● Search Scopus @ Elsevier (DOI): 10.4103/ijd.ijd_405_22 (DOI: 10.4103/ijd.ijd_405_22, PubMed: 37151264)
7.	福田直志, 髙丸菜都美, 秋田和也, 浦田豊彰, 永井和弘, 宮本洋二 : 舌骨近傍に移動した舌内迷入魚骨の1例, 日本口腔外科学会雑誌, Vol.68, No.2, 58-62, 2023年. (キーワード) 魚骨 / 異物 / 舌 / 舌骨 / 術中超音波検査 / fishbone / foreign body / tongue / hyoid bone / intraoperative ultrasonography (出版サイトへのリンク) ● Publication site (DOI): 10.5794/jjoms.69.58 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390295823371025920 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.69.58 (DOI: 10.5794/jjoms.69.58, CiNii: 1390295823371025920)
8.	Keiko Kudoh, Go Ohe, Natsumi Takamaru, Kazuya Akita, Takaharu Kudoh, Akira Takahashi and Youji Miyamoto : Computed tomography-based morphological analysis for intraoral vertical ramus osteotomy in patients with mandibular prognathism, Oral Science International, Vol.21, No.1, 37-45, 2023. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/osi2.1176 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1002/osi2.1176 (DOI: 10.1002/osi2.1176)
9.	Naoyuki Fukuda, Keiko Kudoh, Kazuya Akita, Natsumi Takamaru, 石川邦夫 and Youji Miyamoto : Comparison of bioresorbable bone substitutes, carbonate apatite and β-tricalcium phosphate, for alveolar bone augmentation with simultaneous implant placement., Oral Science International, Vol.20, No.2, 1-8, 2023. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/osi2.1170 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1002/osi2.1170 (DOI: 10.1002/osi2.1170)
10.	Keiko Kudoh, Naoyuki Fukuda, Kazuya Akita, Natsumi Takamaru, Naito Kurio, 石川邦夫 and Youji Miyamoto : Reconstruction of rabbit mandibular bone defects using carbonate apatite honeycomb blocks with an interconnected porous structure., Journal of Materials Science. Materials in Medicine, Vol.34, No.1, 2022. (要約) Carbonate apatite (COAp) granules are useful as a bone substitute because they can be remodeled to new natural bone in a manner that conforms to the bone remodeling process. However, reconstructing large bone defects using COAp granules is difficult because of their granular shape. Therefore, we fabricated COAp honeycomb blocks (HCBs) with continuous unidirectional pores. We aimed to elucidate the tissue response and availability of COAp HCBs in the reconstruction of rabbit mandibular bone defects after marginal mandibulectomy. The percentages of the remaining COAp area and calcified bone area (newly formed bone) were estimated from the histological images. COAp area was 49.1 ± 4.9%, 30.3 ± 3.5%, and 25.5 ± 8.8%, whereas newly formed bone area was 3.0 ± 0.6%, 24.3 ± 3.3%, and 34.7 ± 4.8% at 4, 8, and 12 weeks, respectively, after implantation. Thus, COAp HCBs were gradually resorbed and replaced by new bone. The newly formed bone penetrated most of the pores in the COAp HCBs at 12 weeks after implantation. By contrast, the granulation tissue scarcely invaded the COAp HCBs. Some osteoclasts invaded the wall of COAp HCBs, making resorption pits. Furthermore, many osteoblasts were found on the newly formed bone, indicating ongoing bone remodeling. Blood vessels were also formed inside most of the pores in the COAp HCBs. These findings suggest that COAp HCBs have good osteoconductivity and can be used for the reconstruction of large mandibular bone defects. The COAp HCB were gradually resorbed and replaced by newly formed bone. (キーワード) Animals / Rabbits / Porosity / Apatites / Bone Substitutes / Bone and Bones / Porifera (徳島大学機関リポジトリ) ● Metadata: 118064 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10856-022-06710-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36586041 ● Summary page in Scopus @ Elsevier: 2-s2.0-85145354870 (徳島大学機関リポジトリ: 118064, DOI: 10.1007/s10856-022-06710-2, PubMed: 36586041, Elsevier: Scopus)
11.	Yoshitaka Suzuki, Kazuo Okura, Yasutomo Yoshihara, Junhel Dalanon, Kazuya Akita, Youji Miyamoto and Yoshizo Matsuka : Survey of oral maxillofacial injury experiences and sports mouthguard use in wakeboarders, International Journal of Sports Dentistry, Vol.15, No.1, 17-24, 2022.
12.	山村佳子, 鴨居耕平, 工藤景子, 栗尾奈愛, 鎌田久美子, 横田美保, 上杉篤史, 宮本洋二 : A Case of Ameloblastoma Removed Using a Three-dimensional Transparent Plastic Jaw Model Which Can Visualize Internal Jawbone Structures, Journal of Oral Health and Biosciences, Vol.35, No.1, 9-13, 2022年. (キーワード) ameloblastoma / three-dimensional jaw model / three-dimensional printer / visualization (徳島大学機関リポジトリ) ● Metadata: 117597 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.35.1_9 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390293412207632768 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.35.1_9 (徳島大学機関リポジトリ: 117597, DOI: 10.20738/johb.35.1_9, CiNii: 1390293412207632768)
13.	Yoshiko Yamamura, Keiko Miyoshi, Yasuhiro Mouri, Yasusei Kudo and Youji Miyamoto : miR 155 5p can be involved in acquisition of osseointegration on titanium surface, In Vitro Cellular & Developmental Biology. Animal, Vol.58, No.8, 693-701, 2022. (要約) Dental implants made of titanium are commonly used. Although titanium implants succeed by osseointegration with bone, the detailed molecular mechanism of osseointegration is unclear. To clarify the involvement of microRNA (miRNA) in the acquisition of osseointegration on titanium, here we compared the miRNA expression profiles of mouse osteoblast-like cells (MC3T3-E1) cultured on titanium-, gold-, and stainless steel-coating glass dishes by microarray analysis. Three kinds of metals, namely titanium, gold, and stainless steel, were coated on the surface of the glass dishes by sputtering with similar roughness and shape of their surface. After MC3T3-E1 cells were cultured on the dishes without coating or coating with titanium, gold, or stainless steel for 6 h, total RNA was extracted, and miRNA expression was analyzed by microarray. To confirm the expression of the selected miRNA during osteogenic differentiation of MC3T3-E1 cells, real-time PCR analysis was performed. Furthermore, the effects of selected miRNA were examined by ectopic overexpression in MC3T3-E1 cells. The microarray analysis revealed that the expressions of miR-155-5p and miR-7023-3p were significantly increased in MC3T3-E1 cells cultured on titanium-coating glass dishes, compared to non-coating, gold-, and stainless steel-coating glass dishes. Interestingly, miR-155-5p was upregulated during osteogenic differentiation of MC3T3-E1 cells. Furthermore, overexpression of miR-155-5p enhanced the expression of Runx2 and Col1a1. In this study, miR-155-5p may be involved in the acquisition of osseointegration on titanium implant via upregulating osteogenic differentiation-related genes. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s11626-022-00718-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36053380 ● Search Scopus @ Elsevier (PMID): 36053380 ● Search Scopus @ Elsevier (DOI): 10.1007/s11626-022-00718-2 (DOI: 10.1007/s11626-022-00718-2, PubMed: 36053380)
14.	山村佳子, 福井誠, 工藤隆治, 横田美保, 鎌田久美子, 秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 栗尾奈愛, 宮本洋二 : ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討, 日本口腔ケア学会雑誌, Vol.16, No.2, 52-56, 2022年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520579212289190912 (CiNii: 1520579212289190912)
15.	Tetsuya Nitta, Yoshiko Yamamura, Youji Miyamoto and Hiroshi Kurita : Prevalence of and risk factors for postoperative complications after lower third molar extraction: A multicenter prospective observational study in Japan, Medicine, Vol.101, No.32, e29989, 2022. (要約) Lower third molar extraction is the most common surgical treatment among routine dental and oral surgical procedures. while the surgical procedures for lower third molar extraction are well established, the difficulty of tooth extraction and the frequency of postoperative complications differ depending on the patient's background. To establish a management protocol for the lower third molars, the prevalence of and risk factors for postoperative complications after lower third molar extraction were investigated in a large number of Japanese patients in a multicenter prospective study. During 6 consecutive months in 2020, 1826 lower third molar extractions were performed at the 20 participating institutions. The medical records of the patients were reviewed, and relevant data were extracted. The prevalence of and risk factors for postoperative complications were analyzed. The prevalence of postoperative complications after lower third molar extraction was 10.0%. Multivariate analysis indicated that age (≤32 vs >32, odds ratio [OR]: 1.428, 95% confidence interval [95% CI]: 1.040-1.962, P < .05), the radiographic anatomical relationship between the tooth roots and mandibular canal (overlapping of the roots and canal vs no close anatomical relationship between the roots and the superior border of the canal, OR: 2.078, 95% CI: 1.333-3.238, P < .01; overlapping of the roots and canal vs roots impinging on the superior border of the canal, OR: 1.599, 95% CI: 1.050-2.435, P < .05), and impaction depth according to the Pell and Gregory classification (position C vs position A, OR: 3.7622, 95% CI: 2.079-6.310, P < .001; position C vs position B, OR: 2.574, 95% CI: 1.574-4.210, P < .001) are significant independent risk factors for postoperative complications after lower third molar extraction. These results suggested that higher age and a deeply impacted tooth might be significant independent risk factors for postoperative complications after lower third molar extraction. (キーワード) Humans / Japan / Mandible / Molar, Third / Postoperative Complications / Prevalence / Prospective Studies / Risk Factors / Tooth Extraction / Tooth, Impacted (徳島大学機関リポジトリ) ● Metadata: 117844 (出版サイトへのリンク) ● Publication site (DOI): 10.1097/MD.0000000000029989 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35960058 ● Search Scopus @ Elsevier (PMID): 35960058 ● Search Scopus @ Elsevier (DOI): 10.1097/MD.0000000000029989 (徳島大学機関リポジトリ: 117844, DOI: 10.1097/MD.0000000000029989, PubMed: 35960058)
16.	Masako Fujioka-Kobayashi, Youji Miyamoto, Kunio Ishikawa, Takafumi Satomi and Benoit Schaller : Osteoclast behaviors on the surface of deproteinized bovine bone mineral and carbonate apatite substitutes in vitro, Journal of Biomedical Materials Research. Part A, Vol.110, No.8, 1524-1532, 2022. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.a.37392 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85128206468 (DOI: 10.1002/jbm.a.37392, Elsevier: Scopus)
17.	Takaharu Kudoh, Akihiro Haga, Keiko Kudoh, Akira Takahashi, Motoharu Sasaki, Yasusei Kudo, Hitoshi Ikushima and Youji Miyamoto : Radiomics analysis of [18F]-fluoro-2-deoxyglucose positron emission tomography for the prediction of cervical lymph node metastasis in tongue squamous cell carcinoma, Oral Radiology, 2022. (要約) This study aimed to create a predictive model for cervical lymph node metastasis (CLNM) in patients with tongue squamous cell carcinoma (SCC) based on radiomics features detected by [F]-fluoro-2-deoxyglucose (F-FDG) positron emission tomography (PET). A total of 40 patients with tongue SCC who underwent F-FDG PET imaging during their first medical examination were enrolled. During the follow-up period (mean 28 months), 20 patients had CLNM, including six with late CLNM, whereas the remaining 20 patients did not have CLNM. Radiomics features were extracted from F-FDG PET images of all patients irrespective of metal artifact, and clinicopathological factors were obtained from the medical records. Late CLNM was defined as the CLNM that occurred after major treatment. The least absolute shrinkage and selection operator (LASSO) model was used for radiomics feature selection and sequential data fitting. The receiver operating characteristic curve analysis was used to assess the predictive performance of the F-FDG PET-based model and clinicopathological factors model (CFM) for CLNM. Six radiomics features were selected from LASSO analysis. The average values of the area under the curve (AUC), accuracy, sensitivity, and specificity of radiomics analysis for predicting CLNM from F-FDG PET images were 0.79, 0.68, 0.65, and 0.70, respectively. In contrast, those of the CFM were 0.54, 0.60, 0.60, and 0.60, respectively. The F-FDG PET-based model showed significantly higher AUC than that of the CFM. The F-FDG PET-based model has better potential for diagnosing CLNM and predicting late CLNM in patients with tongue SCC than the CFM. (徳島大学機関リポジトリ) ● Metadata: 116770 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s11282-022-00600-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35254609 ● Summary page in Scopus @ Elsevier: 2-s2.0-85125757133 (徳島大学機関リポジトリ: 116770, DOI: 10.1007/s11282-022-00600-7, PubMed: 35254609, Elsevier: Scopus)
18.	Naoyuki Fukuda, Kunio Ishikawa and Youji Miyamoto : Alveolar ridge preservation in beagle dogs using carbonate apatite bone substitute, Ceramics International, Vol.48, No.2, 1796-1804, 2022. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ceramint.2021.09.260 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85116543247 (DOI: 10.1016/j.ceramint.2021.09.260, Elsevier: Scopus)
19.	Natsumi Takamaru, Naoyuki Fukuda, Kazuya Akita, Keiko Kudoh and Youji Miyamoto : Association of PD L1 and ZEB 1 expression patterns with clinicopathological characteristics and prognosis in oral squamous cell carcinoma, Oncology Letters, Vol.23, No.3, 2022. (要約) Programmed cell death-1 (PD-1) and its ligand programmed cell death 1 ligand 1 (PD-L1) are immune checkpoint inhibitors that play an important role in the host immune avoidance mechanism of tumors. The relationship between PD-L1 expression and malignancy has been reported in various types of cancer, such as lung and gastric cancer. In addition, epithelial-mesenchymal transition (EMT) of cancer cells is deeply involved in the invasion and metastasis of cancer. It has been reported that zinc finger E-box binding homeobox 1 (ZEB-1), an EMT inducer, contributes to metastasis in pancreatic and colon cancer. The present study aimed to investigate the relationship between the expression patterns of two markers, PD-L1 and ZEB-1, and clinicopathological characteristics and prognosis of oral squamous cell carcinoma (OSCC). Biopsy or surgical excision specimens from 169 patients with OSCC were used in the present study. Immunohistochemical staining with monoclonal anti-PD-L1 antibody and anti-ZEB-1 antibody was conducted. Cases with >1% tumor cells positive for PD-L1 and those with >10% tumor cells positive for ZEB-1 were considered positive, respectively. The findings revealed that individual expression of PD-L1 and ZEB-1 in OSCC was not associated with tumor size, degree of differentiation or Yamamoto-Kohama invasion pattern classification. However, co-expression of PD-L1 and ZEB-1 was associated with higher cervical lymph node metastasis and a lower survival rate. In conclusion, the results of the present study indicated that co-expression of PD-L1 and ZEB-1 could serve as a potential marker for the prognosis of patients with OSCC. (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2022.13195 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35111244 ● Summary page in Scopus @ Elsevier: 2-s2.0-85123294766 (DOI: 10.3892/ol.2022.13195, PubMed: 35111244, Elsevier: Scopus)
20.	Y Ogino, Y Ayukawa, N Tachikawa, M Shimogishi, Youji Miyamoto, Keiko Kudoh, Naoyuki Fukuda, K Ishikawa and K Koyano : Staged Sinus Floor Elevation Using Novel Low-Crystalline Carbonate Apatite Granules: Prospective Results after 3-Year Functional Loading., Materials, Vol.14, No.19, 5760, 2021. (徳島大学機関リポジトリ) ● Metadata: 116822 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ma14195760 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85116466459 (徳島大学機関リポジトリ: 116822, DOI: 10.3390/ma14195760, Elsevier: Scopus)
21.	Go Ohe, Yasusei Kudo, Kumiko Kamada, Yasuhiro Mouri, Natsumi Takamaru, Keiko Kudoh, Naito Kurio and Youji Miyamoto : Soluble Factor from Oral Cancer Cell Lines Inhibits Interferon-γ Production by OK-432 via CD40/CD40Ligand Pathway, Cancers, Vol.13, No.13, 2021. (徳島大学機関リポジトリ) ● Metadata: 116508 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/cancers13133301 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85108890231 (徳島大学機関リポジトリ: 116508, DOI: 10.3390/cancers13133301, Elsevier: Scopus)
22.	Akira Takahashi, Kumiko Kamada, Keiko Kudoh, Takaharu Kudoh, Natsumi Takamaru, Naito Kurio, Chieko Sugawara and Youji Miyamoto : Evaluation of anatomical references for locating the course of the posterior superior alveolar artery for dental implant surgery, International Journal of Oral and Maxillofacial Surgery, Vol.51, No.2, 257-262, 2021. (要約) This retrospective cohort study aimed to identify the best anatomical reference for predicting the posterior superior alveolar artery (PSAA) location. Computed tomographic images of 90 maxillary sinuses were evaluated. We studied five references, including the alveolar crest, maxillary sinus floor, zygomatoalveolar crest, hard palate and soft palate, and measured the distances between them and the PSAA. Variations in the distance were evaluated by the standard deviation and coefficient of variation (CV). The zygomatoalveolar crest was an unstable reference, owing to its high standard deviation and CV. The smallest CV was for the distance between the alveolar crest and PSAA, although the distance was smaller in edentulous jaws than dentulous jaws. The distance between the sinus floor and PSAA was larger in male and edentulous patients. The PSAA was detected in 40.0%, 44.4%, 54.4% and 56.7% of the sinus walls at the first and second premolar and the first and second molar positions, respectively. At these tooth positions, the respective heights above the hard palate were 11.2 ± 4.9, 8.2 ± 4.9, 6.2 ± 2.8 and 8.1 ± 2.9 mm. The hard palate was the most stable reference for predicting the location of the PSAA, irrespective of sex, age and dentition. (キーワード) Arteries / Cone-Beam Computed Tomography / Dental Implants / Humans / Male / Maxillary Sinus / Retrospective Studies / Sinus Floor Augmentation (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijom.2021.05.013 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34083086 ● Summary page in Scopus @ Elsevier: 2-s2.0-85107155071 (DOI: 10.1016/j.ijom.2021.05.013, PubMed: 34083086, Elsevier: Scopus)
23.	山村佳子, 眞野隆充, 鎌田久美子, 横田美保, 福田直志, 髙丸菜都美, 工藤景子, 栗尾奈愛, 宮本洋二 : 口腔領域に発症した悪性リンパ腫の臨床的検討, 日本口腔腫瘍学会誌, Vol.33, No.2, 35-60, 2021年. (要約) 2008年から2018年までの11年間に当科で口腔領域に発症した悪性リンパ腫の18例について臨床的特徴を調べた．患者は，平均年齢が70.2歳の男性10例，女性8例であった．原発部位の10例(55.6%)は上顎歯肉で，初期症状は15例(83.3%)で腫瘤と腫脹であった．7例(38.9%)が初診時に臨床的に悪性リンパ腫と診断されたが，その他の11例は正しく診断することが困難であった．腫瘤形成や潰瘍のような様々な臨床症状が診断を困難にしており，1回の生検では確定診断が得られなかった．そこで，血液検査値が診断の指標であるかどうかを検討した．われわれの結果は，17例中8例のLDH(47.1%)と16例中11例のsIL-2R(68.8%)が高い値を示していた．さらに，われわれはリンパ球/単球数比(LMR)が診断に役立つかどうかを調べた．LMRの値は，17例中13例(76.5%)が有意に低く，非ML患者と比較しても有意差を認めた．以上のことより，LMRの血液検査も診断の補助的なマーカーであると考えられた． (キーワード) 悪性リンパ腫 / 臨床試験 / 口腔領域 / リンパ球/単球数比 (徳島大学機関リポジトリ) ● Metadata: 116069 (出版サイトへのリンク) ● Publication site (DOI): 10.5843/jsot.33.35 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390851398293094784 ● Search Scopus @ Elsevier (DOI): 10.5843/jsot.33.35 (徳島大学機関リポジトリ: 116069, DOI: 10.5843/jsot.33.35, CiNii: 1390851398293094784)
24.	Yoshiko Yamamura, Yasusei Kudo, Keiko Kudoh and Youji Miyamoto : Actinomycotic osteomyelitis of the mandible with bone destruction: Two case reports with a review of the Japanese literatures, Oral Science International, 2021. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/osi2.1088 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-85099385266 (DOI: 10.1002/osi2.1088, Elsevier: Scopus)
25.	工藤隆治, 高橋章, 工藤景子, 宮本洋二 : 強度変調放射線治療に伴う放射線性顎骨壊死の頻度と危険因子の検討, 歯科放射線, Vol.60, No.1, 17-20, 2020年. (徳島大学機関リポジトリ) ● Metadata: 115355 (出版サイトへのリンク) ● Publication site (DOI): 10.11242/dentalradiology.60.17 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.11242/dentalradiology.60.17 (徳島大学機関リポジトリ: 115355, DOI: 10.11242/dentalradiology.60.17)
26.	Keiko Kudoh, Kazumi Takaishi, Takaharu Kudoh, Natsumi Takamaru, Kumiko Kamada and Youji Miyamoto : Inferior alveolar nerve paresthesia caused by the extrusion of calcium hydroxide-based paste into themandibular canal: A case report., Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Vol.32, No.5, 366-369, 2020. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ajoms.2020.05.005 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajoms.2020.05.005 (DOI: 10.1016/j.ajoms.2020.05.005)
27.	Takamitsu Mano, Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Naito Kurio, Kunio Ishikawa and Youji Miyamoto : Histological comparison of three apatitic bone substitutes with different carbonate contents in alveolar bone defects in a beagle mandible with simultaneous implant installation., Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.108, No.4, 1450-1459, 2020. (要約) Since bone apatite is a carbonate apatite containing carbonate in an apatitic structure, carbonate content may be one of the factors governing the osteoconductivity of apatitic bone substitutes. The aim of this study was to evaluate the effects of carbonate content on the osteoconductivity of apatitic bone substitutes using three commercially available bone substitutes for the reconstruction of alveolar bone defects of a beagle mandible with simultaneous dental implant installation. NEOBONE, Bio-Oss, and Cytrans that contain 0.1, 5.5, and 12.0 mass% of carbonate, respectively, were used in this study. The amount of newly formed bone in the upper portion of the alveolar bone defect of the beagle's mandible was 0.7, 6.6, and 39.4% at 4 weeks after surgery and 4.7, 39.5, and 75.2% at 12 weeks after surgery for NEOBONE, Bio-Oss, and Cytrans, respectively. The results indicate that bone-to-implant contact ratio was the largest for Cytrans. Additionally, the continuity of the alveolar ridge was restored in the case of Cytrans, whereas the continuity of the alveolar ridge was not sufficient when using NEOBONE and Bio-Oss. Both Cytrans and Bio-Oss that have a relatively larger carbonate content in their apatitic structure was resorbed with time. We concluded that carbonate content is one of important factors governing the osteoconductivity of apatitic bone substitutes. (徳島大学機関リポジトリ) ● Metadata: 113813 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.b.34492 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31622016 ● Search Scopus @ Elsevier (PMID): 31622016 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.34492 (徳島大学機関リポジトリ: 113813, DOI: 10.1002/jbm.b.34492, PubMed: 31622016)
28.	栗尾奈愛, 鎌田久美子, 北川巧, 工藤保誠, 石丸直澄, 宮本洋二 : 上顎歯肉に発症したMicrocystic adnexal carcinomaの1例, 日本口腔外科学会雑誌, Vol.66, No.9, 455-459, 2020年. (要約) <p>Microcystic adnexal carcinoma (MAC) is a rare malignant tumor of skin appendages. MAC grows slowly, but is locally aggressive. The metastatic potential is low, but the recurrence rates are very high owing to insufficient dissection. The most common location of MAC is the skin of the midface of middle-aged adults. There has been no report about MAC arising in the gingiva. We report here an extremely rare case of MAC of the upper gingiva in a 53-year-old woman. She presented to our hospital with a 6-year history of a gradually increasing gingival mass. Intraoral examination revealed a smooth, poorly circumscribed mass with white granules resembling Fordyce spots on her upper gingiva. There was no bone destruction or regional lymph node swelling. The histopathological diagnosis was a tumor of skin appendages. Tumor resection was performed. Postoperative pathological examination revealed that the tumor differentiated into hair follicles and the sweat-gland-like structures and deeply infiltrated into muscle, perineural spaces, and bone. Since the surgical margins were positive, additional resection was performed after preoperative mapping biopsy. Finally, the tumor was completely excised. No tumor recurrence or metastasis have been observed over 1 year.</p> (出版サイトへのリンク) ● Publication site (DOI): 10.5794/jjoms.66.455 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1391975276372989696 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.66.455 (DOI: 10.5794/jjoms.66.455, CiNii: 1391975276372989696)
29.	Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Naito Kurio, Keiko Kudoh, Tsuru Kanji, Ishikawa Kunio and Youji Miyamoto : Fabrication of porous carbonate apatite granules using microfiber and its histological evaluations in rabbit calvarial bone defects, Journal of Biomedical Materials Research. Part A, Vol.108, No.3, 709-721, 2020. (要約) Carbonate apatite (CO Ap) granules are known to show good osteoconductivity and replaced to new bone. On the other hand, it is well known that a porous structure allows bone tissue to penetrate its pores, and the optimal pore size for bone ingrowth is dependent on the composition and structure of the scaffold material. Therefore, the aim of this study was to fabricate various porous CO Ap granules through a two-step dissolution-precipitation reaction using CaSO as a precursor and 30-, 50-, 120-, and 205-μm diameter microfibers as porogen and to find the optimal pore size of CO Ap. Porous CO Ap granules were successfully fabricated with pore size 8.2-18.7% smaller than the size of the original fiber porogen. Two weeks after the reconstruction of rabbit calvarial bone defects using porous CO Ap granules, the largest amount of mature bone was seen to be formed inside the pores of CO Ap (120) [porous CO Ap granules made using 120-μm microfiber] followed by CO Ap (50) and CO Ap (30). At 4 and 8 weeks, no statistically significant difference was observed based on the pore size, even though largest amount of mature bone was formed in case of CO Ap (120). It is concluded, therefore, that the optimal pore size of the CO Ap is that of CO Ap (120), which is 85 μm. (徳島大学機関リポジトリ) ● Metadata: 114682 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.a.36850 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31756282 ● Summary page in Scopus @ Elsevier: 2-s2.0-85076129237 (徳島大学機関リポジトリ: 114682, DOI: 10.1002/jbm.a.36850, PubMed: 31756282, Elsevier: Scopus)
30.	Takayuki Nakagawa, Keiko Kudoh, Naoyuki Fukuda, Noriko Tachikawa, Kiyoshi Koyano, Yasuyuki Matsushita, Kunio Ishikawa and Youji Miyamoto : Application of low-crystalline carbonate apatite granules in 2-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation., Journal of Periodontal & Implant Science, Vol.49, No.6, 382-396, 2019. (要約) The purpose of this study was to elucidate the efficacy and safety of carbonate apatite (COAp) granules in 2-stage sinus floor augmentation through the radiographic and histomorphometric assessment of bone biopsy specimens. Two-stage sinus floor augmentation was performed on 13 patients with a total of 17 implants. Radiographic assessment using panoramic radiographs was performed immediately after augmentation and was also performed 2 additional times, at 7±2 months and 18±2 months post-augmentation, respectively. Bone biopsy specimens taken from planned implant placement sites underwent micro-computed tomography, after which histological sections were prepared. Postoperative healing of the sinus floor augmentation was uneventful in all cases. The mean preoperative residual bone height was 3.5±1.3 mm, and this was increased to 13.3±1.7 mm by augmentation with the COAp granules. The mean height of the augmented site had decreased to 10.7±1.9 mm by 7±2 months after augmentation; however, implants with lengths in the range of 6.5 to 11.5 mm could still be placed. The mean height of the augmented site had decreased to 9.6±1.4 mm by 18±2 months post-augmentation. No implant failure or complications were observed. Few inflammatory cells or foreign body giant cells were observed in the bone biopsy specimens. Although there were individual differences in the amount of new bone detected, new bone was observed to be in direct contact with the COAp granules in all cases, without an intermediate layer of fibrous tissue. The amounts of bone and residual COAp were 33.8%±15.1% and 15.3%±11.9%, respectively. In this first demonstration, low-crystalline COAp granules showed excellent biocompatibility, and bone biopsy showed them to be replaced with bone in humans. COAp granules are a useful and safe bone substitute for two-stage sinus floor augmentation. ICTRP Identifier: JPRN-UMIN000019281. (徳島大学機関リポジトリ) ● Metadata: 114105 (出版サイトへのリンク) ● Publication site (DOI): 10.5051/jpis.2019.49.6.382 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31886030 ● Search Scopus @ Elsevier (PMID): 31886030 ● Search Scopus @ Elsevier (DOI): 10.5051/jpis.2019.49.6.382 (徳島大学機関リポジトリ: 114105, DOI: 10.5051/jpis.2019.49.6.382, PubMed: 31886030)
31.	Kunio Ishikawa, Melvin L. Munar, Kanji Tsuru and Youji Miyamoto : Fabrication of carbonate apatite honeycomb and its tissue response., Journal of Biomedical Materials Research. Part A, Vol.107, No.5, 1014-1020, 2019. (要約) Carbonate apatite (CO Ap) block can be used as a bone substitute because it can be remodeled to new natural bone in a manner conforming with the bone remodeling process. Among the many porous structures available, honeycomb (HC) structure is advantageous for rapid replacement of CO Ap to bone. In this study, the feasibility to fabricate a CO Ap HC was studied, along with its initial tissue response in rabbit femur bone defect. First, a mixture of Ca(OH) and a wax-based binder was extruded from a HC mold. Then the fabricated HC was heated for binder removal and carbonation at 450°C in a mixed O -CO atmosphere, forming a CaCO HC. When the CaCO HC was immersed in 1 mol/L Na PO solution at 80°C for 7 days, its composition changed from CaCO to CO Ap, maintaining the structure of the original CaCO HC. Compressive strengths of the CaCO and CO Ap HCs were 65.2 ± 7.4 MPa and 88.7 ± 4.7 MPa, respectively. When the rabbit femur bone defect was reconstructed with the CO Ap HC, new bone penetrated the CO Ap HC completely. Osteoclasts and osteoblasts were found on the surface of the newly formed bone and osteocytes were also found in the newly formed bone, indicating ongoing bone remodeling. Furthermore, blood vessels were formed inside the pores of CO Ap HC. Therefore, CO Ap HC has good potential as an ideal bone substitute. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1014-1020, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.a.36640 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30706693 ● Summary page in Scopus @ Elsevier: 2-s2.0-85061979238 (DOI: 10.1002/jbm.a.36640, PubMed: 30706693, Elsevier: Scopus)
32.	Naoyuki Fukuda, Kunio Ishikawa, Kazuya Akita, Kumiko Kamada, Naito Kurio, Yoshihide Mori and Youji Miyamoto : Effects of acidic calcium phosphate concentration on setting reaction and tissue response to β-tricalcium phosphate granular cement., Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 2019. (要約) Beta-tricalcium phosphate granular cement (β-TCP GC), consisting of β-TCP granules and an acidic calcium phosphate (Ca-P) solution, shows promise in the reconstruction of bone defects as it sets to form interconnected porous structures, that is, β-TCP granules are bridged with dicalcium phosphate dihydrate (DCPD) crystals. In this study, the effects of acidic Ca-P solution concentration (0-600 mmol/L) on the setting reaction and tissue response to β-TCP GC were investigated. The β-TCP GC set upon mixing with its liquid phase, based on the formation of DCPD crystals, which bridged β-TCP granules to one another. Diametral tensile strength of the set β-TCP GC was relatively the same, at ∼0.6 MPa, when the Ca-P concentration was 20-600 mmol/L. Due to the setting ability, reconstruction of the rat's calvarial bone defect using β-TCP GC with 20, 200, and 600 mmol/L Ca-P solution was much easier compared to that with β-TCP granules without setting ability. Four weeks after the reconstruction, the amount of new bone was the same, ∼17% in both β-TCP GC and β-TCP granules groups. Cellular response to β-TCP granules and β-TCP GC using the 20 mmol/L acidic Ca-P solution was almost the same. However, β-TCP GC using the 200 and 600 mmol/L acidic Ca-P solution showed a more severe inflammatory reaction. It is concluded, therefore, that β-TCP GC, using the 20 mmol/L acidic Ca-P solution, is recommended as this concentration allows surgical techniques to be performed easily and provides good mechanical strength, and the similar cellular response to β-TCP granules. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B, 2019. (徳島大学機関リポジトリ) ● Metadata: 116068 (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.b.34361 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30884116 ● Search Scopus @ Elsevier (PMID): 30884116 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.34361 (徳島大学機関リポジトリ: 116068, DOI: 10.1002/jbm.b.34361, PubMed: 30884116)
33.	Keiko Kudoh, Naoyuki Fukuda, Shohei Kasugai, Noriko Tachikawa, Kiyoshi Koyano, Yasuyuki Matsushita, Yoichiro Ogino, Kunio Ishikawa and Youji Miyamoto : Maxillary Sinus Floor Augmentation Using Low-Crystalline Carbonate Apatite Granules With Simultaneous Implant Installation: First-in-Human Clinical Trial., Journal of Oral and Maxillofacial Surgery, Vol.77, No.5, 985.e1-985.e11, 2018. (要約) Carbonate apatite (COAp), an inorganic component of human bone, can be fabricated in chemically pure form from calcium carbonate block via a dissolution-precipitation reaction. A first-in-human clinical trial was conducted in which low-crystalline COAp granules were evaluated for safety and efficacy in sinus floor augmentation and simultaneous implant installation. Procedures were performed in 8 patients (9 implants) with 2 granule sizes: small (300 to 600 μm) and medium (600 to 1,000 μm). Panoramic radiographic assessment was performed immediately after augmentation, 7 ± 2 months after augmentation, 6 ± 2 months after prosthetic loading, and 12 ± 2 months after prosthetic loading. Postoperative healing was uniformly uneventful, with no abnormal bleeding, pain, or swelling, and all implants achieved successful osseointegration. The mean residual maxillary molar bone height was 5.2 ± 0.8 mm preoperatively and increased to 14.0 ± 1.9 mm after augmentation. Implants 9.0 to 11.5 mm in length were placed. The post-augmentation height decreased to 12.4 ± 1.3 mm at 7 ± 2 months; after prosthetic loading, it decreased to 11.9 ± 0.8 mm at 6 ± 2 months and 11.7 ± 0.6 mm at 12 ± 2 months. No abnormal bone resorption of the augmented areas was observed, and bone height supporting the implants was maintained. The overall implant survival rate was 100%, with no implant failures or complications during the first year. Low-crystalline COAp granules were useful and safe for sinus floor augmentation and simultaneous implant installation, providing a promising bone substitute for dental implant surgery. (キーワード) Apatites / Dental Implantation, Endosseous / Dental Implants / Dental Restoration Failure / Follow-Up Studies / Humans / Maxillary Sinus / Sinus Floor Augmentation / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.joms.2018.11.026 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30597134 ● Summary page in Scopus @ Elsevier: 2-s2.0-85061215753 (DOI: 10.1016/j.joms.2018.11.026, PubMed: 30597134, Elsevier: Scopus)
34.	宮本洋二, 秋田和也, 福田直之, 鎌田久美子, 栗尾奈愛 : 新規骨補填材としての炭酸アパタイトの開発と骨再生医療に向けて, 顎顔面補綴, Vol.41, No.2, 15-19, 2018年.
35.	Masako Fujioka Kobayashi, Kanji Tsuru, Hirokazu Nagai, Kenji Fujisawa, Takaharu Kudoh, Go Ohe, Kunio Ishikawa and Youji Miyamoto : Fabrication and Evaluation of Carbonate Apatite-coated Calcium Carbonate Bone Substitutes for Bone Tissue Engineering, Journal of Tissue Engineering and Regenerative Medicine, Vol.12, No.10, 2077-2087, 2018. (要約) Carbonate apatite-coated calcium carbonate (CO Ap/CaCO ) was fabricated through a dissolution-precipitation reaction using CaCO granules as a precursor to accelerate bone replacement based on superior osteoconductivity of the CO Ap shell, along with Ca release from the CaCO core and quicker resorption of the CaCO core. In the present study, CaCO , 10% CO Ap/CaCO , 30% CO Ap/CaCO , and CO Ap granules were fabricated and examined histologically to evaluate their potential as bone substitutes. Larger contents of CaCO in the granules resulted in higher Ca release and promoted cell proliferation of murine preosteoblasts at 6 days compared with CO Ap. Interestingly, in a rabbit femur defect model, 10% CO Ap/CaCO induced significantly higher new bone formation and higher material resorption compared with CO Ap at 8 weeks. Nevertheless, CO Ap showed a superior osteoconductive potential compared with 10% CO Ap/CaCO at 8 weeks. All tested granules were most likely resorbed by cell mediation including multinucleated giant cell functions. Therefore, we conclude that CO Ap/CaCO has a positive potential for bone tissue engineering based on well-controlled calcium release, bone formation, and material resorption. (出版サイトへのリンク) ● Publication site (DOI): 10.1002/term.2742 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30058260 ● Summary page in Scopus @ Elsevier: 2-s2.0-85052842255 (DOI: 10.1002/term.2742, PubMed: 30058260, Elsevier: Scopus)
36.	Kenji Fujisawa, Kazuya Akita, Naoyuki Fukuda, Kumiko Kamada, Takaharu Kudoh, Go Ohe, Takamitsu Mano, Kanji Tsuru, Kunio Ishikawa and Youji Miyamoto : Compositional and histological comparison of carbonate apatite fabricated by dissolutionprecipitation reaction and Bio-Oss®., Journal of Materials Science. Materials in Medicine, Vol.29, No.8, 121, 2018. (要約) Carbonate apatite (COAp) is an inorganic component of bone. This study aimed to compare the composition and tissue response to of COAp (COAp-DP) fabricated by the dissolution-precipitation reaction using calcite as a precursor and Bio-Oss®, which is widely used in orthopedic and dental fields as a synthetic bone substitute. X-ray diffraction and Fourier transform infrared results showed that COAp-DP and Bio-Oss® were both B-type carbonate apatite with low crystallinity. The average sizes of COAp-DP and Bio-Oss® granules were 450 ± 58 and 667 ± 168μ m, respectively, and their carbonate contents were 12.1 ± 0.6 and 5.6 ± 0.1 wt%, respectively. COAp-DP had a larger amount of CO than Bio-Oss® but higher crystallinity than Bio-Oss®. When a bone defect made at the femur of rabbits was reconstructed with COAp-DP and Bio-Oss®, COAp-DP granules were partially replaced with bone, whereas Bio-Oss® remained at 8 weeks after implantation. COAp-DP granules elicited a significantly larger amount of new bone formation at the cortical bone portion than Bio-Oss® at 4 weeks after the implantation. The results obtained in the present study demonstrated that COAp-DP and Bio-Oss® showed different behavior even though they were both classified as COAp. The CO content in COAp played a more important role than the crystallinity of COAp for replacement to bone and high osteoconductivity. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10856-018-6129-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30032409 ● Summary page in Scopus @ Elsevier: 2-s2.0-85050411033 (DOI: 10.1007/s10856-018-6129-2, PubMed: 30032409, Elsevier: Scopus)
37.	Tetsuya Tamatani, Natsumi Takamaru, Go Ohe, Kazuya Akita, Takayuki Nakagawa and Youji Miyamoto : Expression of CD44,CD44v9ABCG2, CD24,Bmi-1 and ALDH1 in stage andoral spuamous cell carcinoma and their association with clinicopathological factors, Oncology Letters, Vol.16, No.1, 1133-1140, 2018. (要約) Cancer stem cells (CSCs) exhibit self-replication, self-differentiation, drug resistance and immune evasion activities. In recent years CSCs have become increasingly important for the treatment of malignant tumors. CSCs express specific markers, including cluster of differentiation (CD)44, CD44 variant 9 (CD44v9), ATP-binding cassette sub-family G member 2 (ABCG2), CD24, B lymphoma Mo-MLV insertion region 1 homolog (BMI-1) and aldehyde dehydrogenase 1 (ALDH1). However, the prognostic value of their expression in patients with oral squamous cell carcinoma (OSCC) are not well known. The present study evaluated these markers in stage I and II patients with OSCC and examined the association between T classification, histological differentiation, classification of invasion mode, lymph node metastasis and disease-free survival rate. Tissue specimens were obtained from 70 patients with stage I or II OSCC following either surgery or biopsy. Immunohistochemistry was performed and positive staining was defiend as 10% positive cells. CD44 and CD44v9 expressions were strongly detected in all OSCC tissues compared with normal epithelial cells. A total of 22 (31.4%) cases expressed ABCG2 and there was a significant association between ABCG2 expression and invasion. A total of 41 cases (59.0%) expressed CD24 and there was a significant association between CD24 expression and invasion. A total of 33 cases (47.1%) expressed BMI-1 and there was a significant association between BMI-1 expression and the disease-free survival rate. A total of 18 cases (25.7%) expressed ALDH1. Although there was no association between ALDH1 expression and T classification, there were significant associations between ALDH1 expression and histological differentiation, invasion mode, metastasis and the disease-free survival rate. Multivariate analysis revealed that ALDH1 expression was the only prognostic factor for disease-free survival rate. The results of the present study suggest that the positivity of ALDH1 detected in patients with OSCC correlates with the number of cells undergoing epithelial mesenchymal transition and metastasis. These findings indicated that the expression of ALDH1 may be an effective prognostic marker indicating the survival of patients with stage I and II OSCC. (徳島大学機関リポジトリ) ● Metadata: 113599 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2018.8703 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29963189 ● Summary page in Scopus @ Elsevier: 2-s2.0-85047608360 (徳島大学機関リポジトリ: 113599, DOI: 10.3892/ol.2018.8703, PubMed: 29963189, Elsevier: Scopus)
38.	Daisuke Uchida, Nobuyuki Kuribayashi, Makoto Kinouchi, Y Sawatani, M Shimura, T Mori, T Hasegawa, Youji Miyamoto and H Kawamata : Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells., Oncology Reports, Vol.40, No.1, 303-308, 2018. (要約) We have previously demonstrated that the stromal cell-derived factor (SDF-1)/CXCR4 system is involved in the metastasis of head and neck cancer. Additionally, it has been revealed that the blockade of CXCR4 by subcutaneous daily injection with AMD3100, a CXCR4 antagonist, may be effective in preventing metastasis in CXCR4-related head and neck cancer. Recent investigations have suggested that AMD070, a novel orally bioavailable inhibitor of CXCR4, may be minimally invasive compared with AMD3100. In the present study, we examined the effect of AMD070 on metastasis induced by the SDF-1/CXCR4 axis in B88-SDF-1 oral cancer cells, which express high levels of SDF-1 and CXCR4. Although treatment with AMD070 did not affect the anchorage-dependent growth of B88-SDF-1 cells, it significantly suppressed the anchorage-independent growth. Moreover, the SDF-1/CXCR4-dependent migration and invasion of B88-SDF-1 cells was significantly inhibited following treatment with AMD070. Subsequently, we performed an experimental therapy using AMD070 to prevent the distant metastasis of B88-SDF-1 cells in vivo. Daily oral administration of AMD070 significantly inhibited the lung metastasis of B88-SDF-1 cells in nude mice. These results indicated that AMD070 could be useful as a novel orally bioavailable inhibitor of oral cancer metastasis. (キーワード) Administration, Oral / Animals / Biological Availability / Cell Line, Tumor / Heterocyclic Compounds, 1-Ring / Humans / Lung Neoplasms / Mice / Mouth Neoplasms / Neoplasm Metastasis / Receptors, CXCR4 / Xenograft Model Antitumor Assays (出版サイトへのリンク) ● Publication site (DOI): 10.3892/or.2018.6400 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29749473 ● Summary page in Scopus @ Elsevier: 2-s2.0-85047937631 (DOI: 10.3892/or.2018.6400, PubMed: 29749473, Elsevier: Scopus)
39.	Akira Takahashi, Chieko Sugawara, Kazuya Akita, Kumiko Kamada, Keiko Kudoh, Tetsuya Tamatani and Youji Miyamoto : Prevalence and imaging characteristics of nasopharyngeal and eustachian tube tonsilloliths in 2244 patients determined using computed tomography, Dento Maxillo Facial Radiology, Vol.47, 20180052, 2018. (要約) Nasopharyngeal tonsilloliths (NT) and eustachian tube tonsilloliths (ET) are not as well-known to radiologists as palatine and lingual tonsilloliths. The aim of this investigation was to determine the prevalence and imaging characteristics of NT and ET using CT and panoramic radiographs. We retrospectively assessed the scans of 2244 patients who underwent consecutive CT and panoramic radiographs of the maxillofacial region. The prevalence, size, number, and position of NT and ET were analysed. NT and ET were detected in 14 (0.6%) and 6 (0.3%) of 2244 patients on CT, respectively, but they were undetectable on panoramic radiographs. No significant difference was found in the prevalence with respect to sex. Although there was also no significant difference in the prevalence among age groups, tonsilloliths were most commonly noted in patients over 40 years old; they appeared as small and round calcified bodies, ranging from 1 to 3 mm in diameter. All NT were found 0 to 3 mm beneath the nasopharyngeal mucosal surface. The prevalence of NT and ET on CT was lower than that of palatine and lingual tonsilloliths. However, since they are encountered more frequently than clinically significant calcifying diseases such as retropharyngeal calcific tendinitis, clinicians should be able to correctly diagnose NT and ET based on their anatomical features. (キーワード) nasopharynx / eustachian tube / tonsil / calculi / computed tomography / X-Ray (徳島大学機関リポジトリ) ● Metadata: 113564 (出版サイトへのリンク) ● Publication site (DOI): 10.1259/dmfr.20180052 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29714075 ● Search Scopus @ Elsevier (PMID): 29714075 ● Search Scopus @ Elsevier (DOI): 10.1259/dmfr.20180052 (徳島大学機関リポジトリ: 113564, DOI: 10.1259/dmfr.20180052, PubMed: 29714075)
40.	Akira Takahashi, Chieko Sugawara, Keiko Kudoh, Yoshiko Yamamura, Go Ohe, Tetsuya Tamatani and Youji Miyamoto : Lingual tonsillolith: prevalence and imaging characteristics evaluated on 2244 pairs of panoramic radiographs and CT images, Dento Maxillo Facial Radiology, Vol.47, No.1, 20170251, 2018. (要約) Lingual tonsilloliths are not as well-known to radiologists than palatine tonsilloliths, although they might be common in clinical practice. The aim of this investigation was to clarify the prevalence and imaging characteristics of lingual tonsilloliths using panoramic radiographs and CT images. This study included 2244 patients without pathology at the base of tongue who had undergone panoramic radiography and CT of the maxillofacial region. The size, number and position of lingual tonsilloliths relative to the mandible and tongue were evaluated. Lingual tonsilloliths were observed in 33 (1.5%) and 108 (4.8%) of all patients on panoramic radiographs and CT images, respectively. The prevalence was higher in patients aged ≥40 years than in those aged < 40 years (χ, p < 0.01). They appeared as small, round- or rod-shaped calcified bodies, and they always located closely anterior (1-17 mm) to the anterior border of oropharyngeal airway on panoramic radiographs. Lingual tonsilloliths were superimposed over the surrounding soft tissue inferior to the body of the mandible, posteroinferior to the angle of the mandible and posterior to the mandible in 16 (48.5%), 15 (45.5%) and 1 (3.0%) individual, respectively. A significant correlation was observed between the detectability on panoramic radiographs and size (Spearman's r = 0.961, p < 0.01) of tonsilloliths, as revealed by CT images. Lingual tonsilloliths commonly appear on CT. They also appear on panoramic radiography and may superimpose the surrounding soft tissue of the mandible. Although lingual tonsilloliths may resemble other pathological calcifications including submandibular sialoliths and lingual osseous cholistoma, they can be differentiated by carefully observing panoramic radiographs. When clinicians detect calcified bodies near the base of tongue, lingual tonsilloliths should be included in the differential diagnoses. (キーワード) panoramic radiography / X Ray Computed tomography / tonsil / tongue / calculi (徳島大学機関リポジトリ) ● Metadata: 113565 (出版サイトへのリンク) ● Publication site (DOI): 10.1259/dmfr.20170251 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28937280 ● Summary page in Scopus @ Elsevier: 2-s2.0-85040003219 (徳島大学機関リポジトリ: 113565, DOI: 10.1259/dmfr.20170251, PubMed: 28937280, Elsevier: Scopus)
41.	Shinya Sento, Naoya Kitamura, Tetsuya Yamamoto, Koichi Nakashiro, Hiroyuki Hamakawa, Soichiro Ibaragi, Akira Sasaki, Natsumi Takamaru, Youji Miyamoto, Isamu Kodani, Kazuo Ryoke, Katsuaki Mishima and Yoshiya Ueyama : Palonosetron Prevents Highly Emetogenic Chemotherapy-induced Nausea and Vomiting in Oral Cancer Patients, Anticancer Research, Vol.37, No.12, 6977-6981, 2017. (要約) To evaluate the efficacy of palonosetron in preventing acute and delayed nausea and vomiting in patients receiving highly emetogenic chemotherapy (HEC) in oral cancer patients. Oral cancer patients receiving HEC were enrolled; among the 40 patients, 87 courses of chemotherapy were administered. On day 1, 0.75 mg palonosetron was intravenously administrated just before chemotherapy. The primary endpoint was the proportion of patients with a complete response (CR) and the secondary endpoint was the proportion of patients with complete control (CC) during the acute and delayed phase. During the acute phase, 86 of 87 courses (98.9%) had CR and 84 of 87 courses (96.6%) had CC. During the delayed phase, 84 of 87 courses (96.6%) had CR and 70 of 87 courses (80.5%) had CC. Palonosetron is effective at preventing HEC-induced chemotherapy-induced nausea and vomiting (CINV) in oral cancer chemotherapeutic regimens in the acute and delayed phases. (キーワード) Administration, Intravenous / Adult / Aged / Aged, 80 and over / Antineoplastic Agents / Cisplatin / Drug Therapy, Combination / 女性 (female) / Humans / Isoquinolines / 男性 (male) / Middle Aged / Mouth Neoplasms / Nausea / Palonosetron / Quinuclidines / Serotonin Antagonists / Treatment Outcome / Vomiting (出版サイトへのリンク) ● Publication site (DOI): 10.21873/anticanres.12165 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29187483 ● Summary page in Scopus @ Elsevier: 2-s2.0-85038130164 (DOI: 10.21873/anticanres.12165, PubMed: 29187483, Elsevier: Scopus)
42.	工藤景子, 鎌田久美子, 髙丸菜都美, 山村佳子, 大江剛, 工藤隆治, 高橋章, 玉谷哲也, 藤澤健司, 宮本洋二 : 徳島県における口腔がん検診の現状, 日本歯科人間ドック学会誌, Vol.12, No.1, 21-25, 2017年.
43.	Natsumi Takamaru, Tetsuya Tamatani, Go Ohe, Yoshiko Yamamura, Keiko Kudoh and Youji Miyamoto : Single non-contact Nd: YAG laser irradiation treatment for venous malformations in the oral cavity, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Vol.29, No.5, 415-419, 2017. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ajoms.2017.05.010 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ajoms.2017.05.010 (DOI: 10.1016/j.ajoms.2017.05.010)
44.	Satoko Kujiraoka, Takaaki Tsunematsu, Yukiko Sato, Maki Yoshida, Ayataka Ishikawa, Rei Tohyama, Michio Tanaka, Yutaka Kobayashi, Tomoyuki Kondo, Aya Ushio, Kunihiro Otsuka, Mie Kurosawa, Masako Saito, Akiko Yamada, Rieko Arakaki, Hirokazu Nagai, Hiromasa Nikai, Kengo Takeuchi, Toshitaka Nagao, Youji Miyamoto, Naozumi Ishimaru and Yasusei Kudo : Establishment and characterization of a clear cell odontogenic carcinoma cell line with EWSR1-ATF1 fusion gene., Oral Oncology, Vol.69, 46-55, 2017. (要約) To the best of our knowledge, this is the first report on the establishment of a CCOC cell line. CCOC-T cells serve as a useful in vitro model for understanding the pathogenesis and nature of MOT. (徳島大学機関リポジトリ) ● Metadata: 111726 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.oraloncology.2017.04.003 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28559020 ● Search Scopus @ Elsevier (PMID): 28559020 ● Search Scopus @ Elsevier (DOI): 10.1016/j.oraloncology.2017.04.003 (徳島大学機関リポジトリ: 111726, DOI: 10.1016/j.oraloncology.2017.04.003, PubMed: 28559020)
45.	Akira Takahashi, Chieko Sugawara, Takaharu Kudoh, Go Ohe, Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Prevalence and imaging characteristics of palatine tonsilloliths evaluated on 2244 pairs of panoramic radiographs and CT images., Clinical Oral Investigations, Vol.21, No.1, 85-91, 2017. (要約) Palatine tonsilloliths incidentally detected on diagnostic imaging should be differentiated from pathologic calcifications to enable correct diagnosis and treatment. The aim of this study is to clarify the prevalence and imaging characteristics of palatine tonsilloliths on panoramic radiographs. We retrospectively reviewed 2244 individuals who underwent pairs of consecutive panoramic radiography and computed tomography (CT) of the head and neck region. The imaging characteristics of palatine tonsilloliths on panoramic radiography were compared with the findings from CT, which was considered the gold standard. Tonsilloliths were detected in 300 (13.4 %) and 914 (40.7 %) of the 2244 individuals on panoramic radiographs and CT, respectively. On panoramic radiographs, tonsilloliths were superimposed over the ramus of the mandible at the level coincident with and inferior to the soft palate in 176 (7.8 %) and 90 (4.0 %) individuals, respectively. Tonsilloliths were also superimposed over the surrounding soft tissue inferior to the body of the mandible, postero-inferior to the angle of the mandible, and posterior to the ramus of the mandible in 33 (1.5 %), 26 (1.2 %), and 28 (1.3 %) individuals, respectively. A significant correlation was observed between the detectability on panoramic radiographs and the size (Spearman r = 1.000) and number (Spearman r = 0.991) of tonsilloliths, as revealed by CT images. The present results suggest that tonsilloliths are commonly detected on panoramic radiographs. Furthermore, they can be superimposed on both the mandible and the surrounding soft tissue. Clinicians should include tonsilloliths among the differential diagnoses when calcified bodies are detected on panoramic radiographs. (徳島大学機関リポジトリ) ● Metadata: 113566 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00784-016-1752-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26892471 ● Search Scopus @ Elsevier (PMID): 26892471 ● Search Scopus @ Elsevier (DOI): 10.1007/s00784-016-1752-0 (徳島大学機関リポジトリ: 113566, DOI: 10.1007/s00784-016-1752-0, PubMed: 26892471)
46.	Takaharu Kudoh, Hitoshi Ikushima, Keiko Kudoh, Shunsuke Furutani, Takashi Kawanaka, Akiko Kubo, Natsumi Takamaru, Tetsuya Tamatani and Youji Miyamoto : Effectiveness of Newly Developed Water-Equivalent Mouthpiece during External Beam Radiotherapy for Oral Cancer, Ann Carcinog, Vol.2, No.1, 2017. (徳島大学機関リポジトリ) ● Metadata: 113606 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1570009752882329984 (徳島大学機関リポジトリ: 113606, CiNii: 1570009752882329984)
47.	Keiko Kudoh, Takaharu Kudoh, K Tsuru and Youji Miyamoto : A case of tophaceous pseudogout of the temporomandibular joint extending to the base of the skull, International Journal of Oral and Maxillofacial Surgery, Vol.46, No.3, 355-359, 2016. (要約) A case of tophaceous pseudogout (i.e., calcium pyrophosphate dihydrate (CPPD) crystal deposition disease) in the temporomandibular joint (TMJ), extending to the base of the skull, is reported. A 38-year-old man was referred to the hospital with mild pain in the right chin and tip of the tongue. Panoramic radiography showed a large calcified mass around the right TMJ. Computed tomography imaging revealed a large, granular, calcified mass surrounding the right condylar head and extending to the base of the skull. The mass was clinically and radiographically suspected to be a pseudogout lesion. A biopsy specimen was collected under general anaesthesia to confirm the diagnosis. On histology, the mass was found to contain deposits of numerous rod-shaped and rhomboid crystals, which suggested tophaceous pseudogout. The deposits were identified as CPPD crystal deposition, based on analysis by X-ray diffraction and Fourier transform infrared spectroscopy. These two crystallography methods were useful in confirming the diagnosis of CPPD crystal deposition disease in the TMJ. (キーワード) Adult / Biopsy / Chondrocalcinosis / Diagnosis, Differential / Humans / Male / Radiography, Panoramic / Spectroscopy, Fourier Transform Infrared / Temporomandibular Joint Disorders / Tomography, X-Ray Computed / X線回折 (X-ray diffraction) (徳島大学機関リポジトリ) ● Metadata: 112123 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijom.2016.08.018 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27641810 ● Summary page in Scopus @ Elsevier: 2-s2.0-84994787635 (徳島大学機関リポジトリ: 112123, DOI: 10.1016/j.ijom.2016.08.018, PubMed: 27641810, Elsevier: Scopus)
48.	山村佳子, 藤澤健司, 鎌田久美子, 髙丸菜都美, 工藤景子, 大江剛, 工藤隆治, 高橋章, 玉谷哲也, 永井宏和, 宮本洋二 : 口腔がん患者の歯科疾患罹患状況, 日本歯科人間ドック学会誌, Vol.11, No.1, 29-32, 2016年.
49.	藤澤健司, 大江剛, 永井宏和, 安陪晋, 宮本洋二 : 上顎洞底挙上術を併用したインプラントの3年経過後の臨床的評価, 日本口腔インプラント学会誌, Vol.29, No.3, 22-27, 2016年. (要約) <p>The purpose of this study was to evaluate the risk factors for the loss of implants with sinus floor elevation. We statistically carried out a clinical examination on 49 cases, 80 implants at 3 years after the fitting of implant-anchored fixed prostheses.<br/>The results are summarized as follows:<br/>1. Two implants failed in 80 implants, indicating survival rates of 97.5%.<br/>2. There was no statistically significant difference between implant placement timing, initial bone height, sinus membrane thickness, type, diameter, primary stability of implants and graft materials used for sinus floor elevation.<br/>3. The length of implant affected the survival of implants used for sinus floor elevation.</p> (キーワード) sinus floor elevation / lateral window technique / length of implant (出版サイトへのリンク) ● Publication site (DOI): 10.11237/jsoi.29.180 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205511023104 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.29.180 (DOI: 10.11237/jsoi.29.180, CiNii: 1390001205511023104)
50.	Kanae Hara, Kenji Fujisawa, Hirokazu Nagai, Natsumi Takamaru, Go Ohe, Kanji Tsuru, Kunio Ishikawa and Youji Miyamoto : Fabrication and Physical Evaluation of Gelatin-Coated Carbonate Apatite Foam, Materials, Vol.9, No.9, 711, 2016. (要約) Carbonate apatite (CO3Ap) foam has gained much attention in recent years because of its ability to rapidly replace bone. However, its mechanical strength is extremely low for clinical use. In this study, to understand the potential of gelatin-reinforced CO3Ap foam for bone replacement, CO3Ap foam was reinforced with gelatin and the resulting physical characteristics were evaluated. The mechanical strength increased significantly with the gelatin reinforcement. The compressive strength of gelatin-free CO3Ap foam was 74 kPa whereas that of the gelatin-reinforced CO3Ap foam, fabricated using 30 mass % gelatin solution, was approximately 3 MPa. Heat treatment for crosslinking gelatin had little effect on the mechanical strength of the foam. The gelatin-reinforced foam did not maintain its shape when immersed in a saline solution as this promoted swelling of the gelatin; however, in the same conditions, the heat-treated gelatin-reinforced foam proved to be stable. It is concluded, therefore, that heat treatment is the key to the fabrication of stable gelatin-reinforced CO3Ap foam. (徳島大学機関リポジトリ) ● Metadata: 113607 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ma9090711 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28773832 ● Summary page in Scopus @ Elsevier: 2-s2.0-84988983311 (徳島大学機関リポジトリ: 113607, DOI: 10.3390/ma9090711, PubMed: 28773832, Elsevier: Scopus)
51.	Chieko Sugawara, Akira Takahashi, Fumiaki Kawano, Yasusei Kudo, Naozumi Ishimaru and Youji Miyamoto : Intraoral Ultrasonography of Tongue Mass Lesions, Dento Maxillo Facial Radiology, Vol.45, No.5, 20150362, 2016. (要約) To demonstrate the usefulness of intraoral ultrasonography (IOUS) for tongue mass lesions, we analyzed surgery cases excluding squamous-cell carcinoma and leukoplakia and compared IOUS and pathological findings. We used the hospital information system and Radiology Information System to evaluate the IOUS and pathological findings of patients who underwent surgeries for tongue masses in the past 11 years. Surgeries for the tongues were performed in 268 cases. Imaging examinations were carried out in 52 (19.4%) cases including 42 (15.7%) cases by IOUS. The pathological results of the surgeries were as follows: 36 cases were inflammatory lesions, 74 cases were tumours, 131 cases were hyperplasia, 8 cases were cystic lesions and 19 cases were other miscellaneous lesions. On the other hand, the number of patients who received IOUS in the same period was 87, and 42 of them had surgeries. In 32 out of the 42 (76.2%) cases, pre-operative IOUS features matched with pathological results. Most of the haemangiomas and lipomas could be diagnosed by IOUS alone. IOUS of the tongue revealed the nature of the lesions including the border, size, location, depth, the presence or absence of a capsule and the internal structure including vascularity of the mass. The ultrasonographic findings well reflected the histological findings. IOUS is a simple and useful technique that provides additional information beyond inspection, clarifying the internal structure, blood flow and relationships with the adjacent tissues. In this article, we indicated 11 representative cases (fibrous polyp, haemangioma, pyogenic granuloma, lipoma, liposarcoma, chondroma, lymphangioma, schwannoma, neurofibroma, pleomorphic adenoma and amyloidosis) to show the usefulness of IOUS. (キーワード) 超音波 (ultrasound) (徳島大学機関リポジトリ) ● Metadata: 111906 (出版サイトへのリンク) ● Publication site (DOI): 10.1259/dmfr.20150362 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26915405 ● Search Scopus @ Elsevier (PMID): 26915405 ● Search Scopus @ Elsevier (DOI): 10.1259/dmfr.20150362 (徳島大学機関リポジトリ: 111906, DOI: 10.1259/dmfr.20150362, PubMed: 26915405)
52.	Maki Hosoki, Keisuke Nishigawa, Youji Miyamoto, Go Ohe and Yoshizo Matsuka : Allergic contact dermatitis caused by titanium screws and dental implants, Journal of Prosthodontic Research, Vol.60, No.3, 213-219, 2016. (要約) Titanium has been considered to be a non-allergenic material. However, several studies have reported cases of metal allergy caused by titanium-containing materials. We describe a 69-year-old male for whom significant pathologic findings around dental implants had never been observed. He exhibited allergic symptoms (eczema) after orthopedic surgery. The titanium screws used in the orthopedic surgery that he underwent were removed 1 year later, but the eczema remained. After removal of dental implants, the eczema disappeared completely. Titanium is used not only for medical applications such as plastic surgery and/or dental implants, but also for paints, white pigments, photocatalysts, and various types of everyday goods. Most of the usage of titanium is in the form of titanium dioxide. This rapid expansion of titanium-containing products has increased percutaneous and permucosal exposure of titanium to the population. In general, allergic risk of titanium material is smaller than that of other metal materials. However, we suggest that pre-implant patients should be asked about a history of hypersensitivity reactions to metals, and patch testing should be recommended to patients who have experienced such reactions. (キーワード) Aged / Bone Screws / Dental Implants / Dental Materials / Dermatitis, Allergic Contact / Device Removal / Humans / Male / Orthopedic Procedures / チタン (titanium) (徳島大学機関リポジトリ) ● Metadata: 111970 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jpor.2015.12.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26774509 ● CiNii @ 国立情報学研究所 (CRID): 1390282680276696576 ● Summary page in Scopus @ Elsevier: 2-s2.0-84953449555 (徳島大学機関リポジトリ: 111970, DOI: 10.1016/j.jpor.2015.12.004, PubMed: 26774509, CiNii: 1390282680276696576, Elsevier: Scopus)
53.	Natsumi Takamaru, Hirokazu Nagai, Go Ohe, Tetsuya Tamatani, Kaori Sumida, Seiichiro Kitamura and Youji Miyamoto : Measurement of the zygomatic bone and pilot hole technique for safer insertion of zygomaticus implants, International Journal of Oral and Maxillofacial Surgery, Vol.45, No.1, 104-109, 2016. (要約) The zygomaticus implant was developed for patients with severe bone resorption of the posterior maxilla. These may eliminate or minimize the need for bone grafting. Although the zygomaticus implant has shown a remarkable success rate in this difficult-to-treat patient population, the method requires an advanced surgical technique and carries an increased risk of complications. There have been few anatomical studies on the zygomatic bone in relation to the insertion of zygomaticus implants. The height and thickness of the zygomatic bone for the insertion were measured in this study. The thickness at the 90° angle point, where the upper margin of the zygomatic arch and the temporal margin of the frontal process of the zygomatic bone intersect and where the apex of the implant penetrates, was found to be 1.8±0.4 mm; this gradually increased inferiorly and anteriorly. Thus, the penetration point of the apex of the zygomaticus implant should be located more inferoanterior to the 90° angle point, as the thickness in this region is thinner than the diameter of the implant. Based on the results of this study, a newer and safer insertion method for the zygomaticus implant using a drill guide is proposed. (徳島大学機関リポジトリ) ● Metadata: 114011 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijom.2015.07.015 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26395065 ● Summary page in Scopus @ Elsevier: 2-s2.0-84952870149 (徳島大学機関リポジトリ: 114011, DOI: 10.1016/j.ijom.2015.07.015, PubMed: 26395065, Elsevier: Scopus)
54.	山本修史, 藤澤健司, 大江剛, 永井宏和, 宮本洋二 : インプラントの表面性状がオッセオインテグレーション喪失に及ぼす影響:滑面(機械加工面)と粗面(陽極酸化面)インプラント体の比較, 日本口腔インプラント学会誌, Vol.28, No.3, 18-25, 2015年. (出版サイトへのリンク) ● Publication site (DOI): 10.11237/jsoi.28.318 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.28.318 (DOI: 10.11237/jsoi.28.318)
55.	藤澤健司, 大江剛, 永井宏和, 安陪晋, 宮本洋二 : インプラント体の表面性状の違いが周囲骨吸収に及ぼす影響:埋入後5年経過時の同一患者の隣接するインプラント体により比較, 日本口腔インプラント学会誌, Vol.28, No.3, 12-17, 2015年. (出版サイトへのリンク) ● Publication site (DOI): 10.11237/jsoi.28.312 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.28.312 (DOI: 10.11237/jsoi.28.312)
56.	Hirokazu Nagai, Masako Fujioka-Kobayashi, Kenji Fujisawa, Go Ohe, Natsumi Takamaru, Kanae Hara, Daisuke Uchida, Tetsuya Tamatani, Kunio Ishikawa and Youji Miyamoto : Effects of low crystalline carbonate apatite on proliferation and osteoblastic differentiation of human bone marrow cells, Journal of Materials Science. Materials in Medicine, Vol.26, No.2, 99, 2015. (要約) Carbonated apatite (CO3Ap) is the inorganic component of bone. We have proposed a new method for the fabrication of CO3Ap blocks based on a dissolution-precipitation method using a synthetic precursor. The aim of this study is to examine the effects of low crystalline CO3Ap on initial cell attachment, proliferation and osteoblastic differentiation of human bone marrow cells (hBMCs) using sintered hydroxyapatite and tissue culture plates as controls. Initial cell attachment and proliferation were assessed with a MTT assay. Expression of osteoblastic markers was examined by reverse transcription-polymerase chain reaction. XRD and FT-IR results showed formation of B-type carbonate apatite with lower crystallinity. No difference was observed for initial cell attachment between HAp and CO3Ap discs. hBMSC attached more significantly on tissue culture plate than on HAp and CO3Ap discs. The number of cells on HAp was higher than that on CO3Ap until day 7, after which the number of cells was similar. hBMSC proliferated more significantly on tissue culture plate than on HAp and CO3Ap discs. In contrast, hBMCs incubated on CO3Ap demonstrated much higher expression of osteoblastic markers of differentiation, such as type I collagen, alkaline phosphatase, osteopontin and osteocalcin, than hBMCs on HAp. On the tissue culture plate, they were not any change throughout the culture period. These results demonstrated that low crystalline CO3Ap exhibit higher osteoinductivity than HAp. (キーワード) Alkaline Phosphatase / Apatites / Biomarkers / Bone Marrow Cells / Bone Substitutes / Cell Adhesion / Cell Culture Techniques / 細胞分化 (cell differentiation) / Cell Proliferation / Collagen Type I / 結晶化 (crystallization) / Durapatite / Humans / Materials Testing / Osteoblasts / Osteocalcin / Osteogenesis / オステオポンティン (osteopontin) / Spectroscopy, Fourier Transform Infrared / X線回折 (X-ray diffraction) (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10856-015-5431-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25655499 ● Summary page in Scopus @ Elsevier: 2-s2.0-84922324403 (DOI: 10.1007/s10856-015-5431-5, PubMed: 25655499, Elsevier: Scopus)
57.	Chieko Sugawara, Akira Takahashi, Fumiaki Kawano, Takaharu Kudoh, Akiko Yamada, Naozumi Ishimaru, Hara Kanae and Youji Miyamoto : Neuroendocrine tumor in the mandible: a case report with imaging and histopathologic findings, Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol.119, No.1, e41-e48, 2015. (要約) Neuroendocrine tumors (NETs) arise from neuroendocrine cells and are mostly observed in the gastrointestinal tract, pancreas, and lungs. NETs in the oral and maxillofacial region are extremely rare. We report a case of a 59-year-old woman with an NET in the mandible. The patient did not show any symptoms except for remarkable swelling and bleeding. The lesion appeared as a radiolucent honeycomb abnormality with bone destruction on panoramic radiography. The histopathologic diagnosis following a biopsy was NET. Contrast-enhanced computed tomography (CT), (18)F-fluorodeoxyglucose positron emission computed tomography ((18)F-FDG PET/CT), and adrenal scintigraphy-labeled meta-iodobenylguanidine were the modalities added to identify the primary site. Multiple lesions were confirmed in the gastrointestinal tract. Endoscopy was performed to identify the lesions, and several lesions were observed protruding from the mucous membranes. However, the endoscopy specimens did not yield an accurate diagnosis because adequate samples were not acquired. Blood and urine tests revealed no functional activity caused by the tumors. Although the origin was not histopathologically confirmed with endoscopy, this patient was situationally diagnosed with nonfunctional NET originating from the duodenum, as demonstrated by the metastases in the mandible. (キーワード) neuroendocrine tumor / neuroendocrine carcinoma / oral cavity / synaptophysin / chromogranin A (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.oooo.2014.09.024 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25459356 ● Summary page in Scopus @ Elsevier: 2-s2.0-84915767535 (DOI: 10.1016/j.oooo.2014.09.024, PubMed: 25459356, Elsevier: Scopus)
58.	Makoto Kinouchi, Daisuke Uchida, Nobuyuki Kuribayashi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Involvement of miR-518c-5p to Growth and Metastasis in Oral Cancer, PLoS ONE, Vol.9, No.12, e115936, 2014. (要約) We have previously demonstrated that a stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of metastasis in oral cancer. Recently, small non coding RNAs, microRNAs (miRNAs) have been shown to be involved in the metastatic process of several types of cancers. However, the miRNAs that contribute to metastases induced by the SDF-1/CXCR4 system in oral cancer are largely unknown. In this study, we examined the metastasis-related miRNAs induced by the SDF-1/CXCR4 system using B88-SDF-1 oral cancer cells, which exhibit functional CXCR4 and distant metastatic potential in vivo. Through miRNA microarray analysis, we identified the upregulation of miR-518c-5p in B88-SDF-1 cells, and confirmed the induction by real-time PCR analysis. Although an LNA-based miR-518c-5p inhibitor did not affect cell growth of B88-SDF-1 cells, it did significantly inhibit the migration of the cells. Next, we transfected a miR-518c expression vector into parental B88 cells and CAL27 oral cancer cells and isolated stable transfectants, B88-518c and CAL27-518c cells, respectively. The anchorage-dependent and -independent growth of miR-518c transfectants was significantly enhanced compared with the growth of mock cells. Moreover, we detected the enhanced migration of these cells. The LNA-based miR-518c-5p inhibitor significantly impaired the enhanced cell growth and migration of miR-518c transfectants, indicating that these phenomena were mainly dependent on the expression of miR-518c-5p. Next, we examined the function of miR-518c-5p in vivo. miR-518c transfectants or mock transfectants were inoculated into the masseter muscle or the blood vessels of nude mice. Tumor volume, lymph nodes metastasis, and lung metastasis were significantly increased in the mice inoculated with the miR-518c transfectants. These results indicated that miR-518c-5p regulates the growth and metastasis of oral cancer as a downstream target of the SDF-1/CXCR4 system. (徳島大学機関リポジトリ) ● Metadata: 109400 (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0115936 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25536052 ● Summary page in Scopus @ Elsevier: 2-s2.0-84919809244 (徳島大学機関リポジトリ: 109400, DOI: 10.1371/journal.pone.0115936, PubMed: 25536052, Elsevier: Scopus)
59.	Akira Takahashi, Chieko Sugawara, Takaharu Kudoh, Daisuke Uchida, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Prevalence and Imaging Characteristics of Palatine Tonsilloloths Detected by CT in 2,873 Consecutive Patients, The Scientific World Journal, 2014. (徳島大学機関リポジトリ) ● Metadata: 113567 (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2014/940960 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25389536 ● Summary page in Scopus @ Elsevier: 2-s2.0-84908347485 (徳島大学機関リポジトリ: 113567, DOI: 10.1155/2014/940960, PubMed: 25389536, Elsevier: Scopus)
60.	Yoshiro Abe, Ichiro Hashimoto, Shinji Matsuo, Keiichi Goishi, Keisuke Kashiwagi, Hirokazu Nagai, Youji Miyamoto and Hideki Nakanishi : Three-dimensional sodium chloride (NaCI) model for simulated mandibular reconstruction surgery : a new environmentally friendly material, The Journal of Medical Investigation : JMI, Vol.61, No.3,4, 318-324, 2014. (要約) Mandibular reconstruction using a fibular graft is a difficult procedure that requires technical expertise to enable adequate occlusal function and restore an aesthetic appearance. Here we used three-dimensional (3D) sodium chloride (NaCl) models for simulated mandibular reconstruction surgery. This study aimed to reveal the accuracy of mandibular reconstruction with fibular grafts using this model. Mandibular reconstructions using 3D NaCl models were performed in 5 cases. The maxilla, mandible, and fibular models were developed using computed tomography (CT) data. We performed preoperative cutting and simulation surgery using this model. Angles between the body of the corpus and symphysis were measured from the axial view (n = 4). Angles between the ramus and the body of the corpus were measured from the lateral and axial views (n = 6). These angles were measured on simulated models and postoperative CT images were compared. Differences between the angles measured on the simulated models and postoperative CT images were 0-5° (mean, 1.9°). We were able to reproduce the neomandibles with precise osteotomies using the 3D NaCl models. We believe that simulated mandibular reconstruction surgery using this model might help reduce the number of intraoperative neomandibular segment adjustments. (徳島大学機関リポジトリ) ● Metadata: 109579 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.61.318 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25264050 ● Summary page in Scopus @ Elsevier: 2-s2.0-84907501630 (徳島大学機関リポジトリ: 109579, DOI: 10.2152/jmi.61.318, PubMed: 25264050, Elsevier: Scopus)
61.	Hirokazu Nagai, Masako Fujioka-Kobayashi, Go Ohe, Kanae Hara, Natsumi Takamaru, Daisuke Uchida, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : Antitumour effect of valproic acid against salivary gland cancer in vitro and in vivo, Oncology Reports, Vol.31, No.3, 1453-1458, 2014. (要約) Salivary gland cancer (SGC) has a comparatively poor prognosis and is prone to frequent recurrence and metastases. Therefore, the development of more effective chemotherapy against SGC is desirable. The aim of the present study was to investigate the antitumour effects of valproic acid (VPA) against SGC in vitro and in vivo. Two human SGC cell lines (HSY and HSG cells) were used in the present study. The effects of VPA on the proliferation of SGC cells in vitro were assessed by MTT assay. Cancer cells treated with VPA were subjected to cell cycle analysis by flow cytometry. In addition, the expression levels of p21 and p27 were examined by real-time RT-PCR to identify the mechanisms of the antitumour effect of VPA on SGC. The effects of VPA on cancer growth in vivo were evaluated in a xenograft model. VPA inhibited the proliferation of SGC cells in a dose-dependent manner in vitro. Degenerated cancer cells were observed at high concentrations of VPA. In the cell cycle analysis, VPA induced cell-growth inhibition and G1 arrest of cell cycle progression in both cancer cell lines in a time- and dose-dependent manner. VPA markedly upregulated the mRNA expression levels of both p21 and p27 in both SGC cell lines in a time-dependent manner. In the xenograft model experiment, VPA treatment markedly inhibited the growth of salivary gland tumours when compared with the growth of the untreated controls. VPA may be a valuable drug in the development of better therapeutic regimens for SGC. (キーワード) Adenocarcinoma / Animals / Antineoplastic Agents / Cell Line, Tumor / Cell Survival / Cyclin-Dependent Kinase Inhibitor p21 / Cyclin-Dependent Kinase Inhibitor p27 / Gene Expression / Humans / Mice / Mice, Inbred BALB C / Mice, Nude / Salivary Gland Neoplasms / Valproic Acid / Xenograft Model Antitumor Assays (徳島大学機関リポジトリ) ● Metadata: 113603 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/or.2013.2959 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24398788 ● Summary page in Scopus @ Elsevier: 2-s2.0-84896709497 (徳島大学機関リポジトリ: 113603, DOI: 10.3892/or.2013.2959, PubMed: 24398788, Elsevier: Scopus)
62.	藤原慎視, 中村竜也, 永田久美子, 桂智子, 塩田智子, 堀内信也, 黒田晋吾, 清家卓也, 橋本一郎, 中西秀樹, 永井宏和, 宮本洋二, 田中栄二 : 顎顔面領域における骨治癒に対する低出力超音波パルス照射の使用経験, 四国歯学会雑誌, Vol.26, No.2, 41-47, 2014年. (徳島大学機関リポジトリ) ● Metadata: 109843 (徳島大学機関リポジトリ: 109843)
63.	藤澤健司, 大江剛, 内田大亮, 玉谷哲也, 永井宏和, 宮本洋二 : ショートインプラントの有用性に関する臨床的検討, 日本口腔インプラント学会誌, Vol.26, No.4, 26-33, 2013年. (要約) The purpose of this study was to determine whether clinical success can be achieved with Brånemark system short implants (Nobel Biocare) three years after the placement of implants. <br/>One hundred and thirteen short implants (10 mm) were installed:42 implants with smooth surfaces and 71 implants with rough surfaces. Twenty-two implants were installed in the maxilla, and 91 implants in the mandible. All implants were submerged. A chi-square test was used to evaluate the significance of implant loss of short implants with implants longer than 10 mm.<br/>There was no significant difference in the failure rates between short implants and implants longer than 10 mm. Among smooth surface implants, the failure rate of short implants was significantly higher than that of implants longer than 10 mm, but among rough surface implants, no significant difference in the failure rates was observed between short implants and implants longer than 10 mm. These results demonstrated that short implants with rough surfaces were as useful as implants longer than 10 mm. (キーワード) short implants / implant surface roughness (出版サイトへのリンク) ● Publication site (DOI): 10.11237/jsoi.26.676 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205506584064 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.26.676 (DOI: 10.11237/jsoi.26.676, CiNii: 1390001205506584064)
64.	Nobuyuki Kuribayashi, Daisuke Uchida, Makoto Kinouchi, Natsumi Takamaru, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : The Role of Metabotropic Glutamate Receptor 5 on the Stromal Cell-Derived Factor-1/CXCR4 System in Oral Cancer, PLoS ONE, Vol.8, No.11, e80773, 2013. (要約) We have demonstrated that blocking CXCR4 may be a potent anti-metastatic therapy for CXCR4-related oral cancer. However, as CXCR4 antagonists are currently in clinical use to induce the mobilization of hematopoietic stem cells, continuous administration as an inhibitor for the metastasis may lead to persistent leukocytosis. In this study, we investigated the novel therapeutic downstream target(s) of the SDF-1/CXCR4 system, using B88-SDF-1 cells, which have an autocrine SDF-1/CXCR4 system and exhibit distant metastatic potential in vivo. Microarray analysis revealed that 418 genes were upregulated in B88-SDF-1 cells. We identified a gene that is highly upregulated in B88-SDF-1 cells, metabotropic glutamate receptor 5 (mGluR5), which was downregulated following treatment with 1,1' -[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD3100), a CXCR4 antagonist. The upregulation of mGluR5 mRNA in the SDF-1/CXCR4 system was predominately regulated by the Ras-extracellular signal-regulated kinase (ERK)1/2 pathway. Additionally, the growth of B88-SDF-1 cells was not affected by the mGluR5 agonist (S)-3,5-DHPG (DHPG) or the mGluR5 antagonists 2-Methyl-6-(phenylethynyl)pyridine (MPEP) and 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP). However, we observed that DHPG promoted B88-SDF-1 cell migration, whereas both MPEP and MTEP inhibited B88-SDF-1 cell migration. To assess drug toxicity, the antagonists were intraperitoneally injected into immunocompetent mice for 4 weeks. Mice injected with MPEP (5 mg/kg) and MTEP (5 mg/kg) did not exhibit any side effects, such as hematotoxicity, allergic reactions or weight loss. The administration of antagonists significantly inhibited the metastasis of B88-SDF-1 cells to the lungs of nude mice. These results suggest that blocking mGluR5 with antagonists such as MPEP and MTEP could prevent metastasis in CXCR4-related oral cancer without causing side effects. (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0080773 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24236200 ● Search Scopus @ Elsevier (PMID): 24236200 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0080773 (DOI: 10.1371/journal.pone.0080773, PubMed: 24236200)
65.	Go Ohe, Akiko Sasai, Daisuke Uchida, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Effect of soluble factors derived from oral cancer cells on the production of interferon-γ from peripheral blood mononuclear cells following stimulation with OK-432, Oncology Reports, Vol.30, No.2, 945-951, 2013. (要約) The streptococcal antitumor agent OK-432 is commonly used as an immunopotentiator for immunotherapy in various types of malignant tumors including oral cancer. It has been demonstrated that OK-432 elicits an antitumor effect by stimulating immunocompetent cells, thereby inducing multiple cytokines including interferon (IFN)-γ, interleukin (IL)-2 and IL-12. Serum concentrations of IFN-γ in patients with oral cancer were examined 24 h after administration of OK-432. Serum concentrations of IFN-γ in patients with advanced cancer were significantly lower than those in patients with early cancer. These results suggested that some soluble factors produced by cancer cells may inhibit IFN-γ production with OK-432. Thus, in the present study, an in vitro simulation model was established for the immune status of patients with oral cancer by adding conditioned medium (CM) derived from oral cancer cell lines into a culture of peripheral blood mononuclear cells (PBMCs) derived from a healthy volunteer. We investigated whether soluble factors derived from oral cancer cells affected IFN-γ production from PBMCs following stimulation with OK-432. PBMCs stimulated with OK-432 produced a large amount of IFN-γ; however, both IFN-γ production and cytotoxic activity from PBMCs induced by OK-432 were inhibited by the addition of CM in a dose-dependent manner. In order to examine these inhibitory effects against IFN-γ production, the contribution of inhibitory cytokines such as IL-4, IL-6, IL-10, transforming growth factor-β and vascular endothelial growth factor was investigated. However, neutralization of these inhibitory cytokines did not recover IFN-γ production inhibited by CM. These results indicated that unknown molecules may inhibit IFN-γ production from PBMCs following stimulation with OK-432. (徳島大学機関リポジトリ) ● Metadata: 113600 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/or.2013.2480 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23685791 ● Search Scopus @ Elsevier (PMID): 23685791 ● Search Scopus @ Elsevier (DOI): 10.3892/or.2013.2480 (徳島大学機関リポジトリ: 113600, DOI: 10.3892/or.2013.2480, PubMed: 23685791)
66.	Tetsuya Tamatani, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : Bortezomib-enhanced radiosensitization through the suppression of radiation-induced nuclear factor B activity in human oral cancer cells., International Journal of Oncology, Vol.42, No.3, 935-944, 2013. (要約) Oral cancer cells have a significantly augmented nuclear factor-κB (NF-κB) activity and the inhibition of this activity suppresses tumor growth. Bortezomib is a proteasome inhibitor and a drug used for molecular-targeted therapy (targets NF-κB). In this study, we investigated whether bortezomib would be effective as an inhibitor of proliferation and a radiosensitizer for the treatment of oral cancer. We demonstrate that bortezomib inhibits NF-κB activity and cell proliferation. The combined treatment with bortezomib and radiation (RT) suppressed NF-κB activity and cell growth in vitro and in vivo compared with RT treatment alone. To investigate the mechanisms by which bortezomib suppresses tumor growth, the expression of signaling molecules downstream of NF-κB were examined by ELISA. The combined treatment significantly inhibited the radiation-induced production of angiogenic factors and decreased the number of blood vessels in the tumor tissues. Although the expression of anti-apoptotic proteins was upregulated by RT, bortezomib downregulated the RT-induced expression of these proteins. Moreover, the expression of cleaved poly(ADP-ribose) polymerase in vitro and in vivo was enhanced by bortezomib, indicating that bortezomib inhibits tumor growth by inducing apoptosis. This study clearly demonstrates that bortezomib significantly inhibits tumor growth and that the combined treatment with bortezomib and RT results in a significant inhibition of tumor growth. The mechanisms underlying the inhibition of tumor growth by bortezomib include the suppression of angiogenesis and the induction of apoptosis. A novel molecular targeting therapy including bortezomib may be effective in the treatment of oral cancer by suppressing NF-κB activity. (キーワード) Animals / Antineoplastic Agents / Apoptosis / Boronic Acids / Cell Line, Tumor / Cell Proliferation / Female / Humans / I-kappa B Proteins / Interleukin-6 / Interleukin-8 / Mice / Mice, Inbred BALB C / Mice, Nude / Mouth Neoplasms / NF-kappa B / Neoplasm Transplantation / Neovascularization, Pathologic / Poly(ADP-ribose) Polymerases / Pyrazines / Radiation-Sensitizing Agents / Transcription Factor RelA / Vascular Endothelial Growth Factor A / Xenograft Model Antitumor Assays (徳島大学機関リポジトリ) ● Metadata: 113601 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ijo.2013.1786 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23340716 ● Search Scopus @ Elsevier (PMID): 23340716 ● Search Scopus @ Elsevier (DOI): 10.3892/ijo.2013.1786 (徳島大学機関リポジトリ: 113601, DOI: 10.3892/ijo.2013.1786, PubMed: 23340716)
67.	Daisuke Uchida, Nobuyuki Kuribayashi, Go Ohe, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Expression and function of CXCR4 in human salivary gland cancers, Clinical & Experimental Metastasis, Vol.30, No.2, 133-142, 2013. (要約) Salivary gland cancers (SGCs) frequently metastasize to cervical lymph nodes and distant organs. Currently, the mechanisms responsible for the metastatic behavior of SGC cells are not fully understood. We previously demonstrated that the stromal cell-derived factor-1 (SDF-1; also known as CXCL12)/CXCR4 system is involved in the establishment of metastasis in oral squamous cell carcinoma. In the present study, we investigated the role of CXCR4 in the metastatic behavior of SGCs. We examined the expression of CXCR4 mRNA and protein in human SGC cell lines by quantitative RT-PCR and western blotting, respectively. The expression of CXCR4 mRNA and protein were frequently upregulated in 5 out of 6 SGC cell lines. Functional CXCR4 expression was demonstrated by the ability of these SGC cell lines to migrate toward an SDF-1 gradient. SDF-1 rapidly activated extracellular signal-regulated kinase (ERK)1/2 in SGC cell lines. Immunohistochemical analysis revealed that CXCR4 protein expression was detected in either the nucleus or cytoplasm of cancer cells in 16 out of 20 tissues of adenoid cystic carcinoma (ACC) and in 4 out of 6 tissues of mucoepidermoid carcinoma, which are representative of SGC. Furthermore, ACC cell lines exhibited dramatic metastasis to the lung following intravenous inoculation, whereas AMD3100, a CXCR4 antagonist, significantly inhibited lung metastasis of the cells, ameliorated body weight loss and improved the survival rate of tumor-bearing nude mice. These results indicate that CXCR4 expression contributes to the metastatic potential of SGCs. (キーワード) Animals / Blotting, Western / Carcinoma, Squamous Cell / Cell Adhesion / Cell Movement / Chemokine CXCL12 / Enzyme-Linked Immunosorbent Assay / Flow Cytometry / Heterocyclic Compounds / Humans / Immunoenzyme Techniques / Lung Neoplasms / Lymphatic Metastasis / Mice / Mice, Inbred BALB C / Mice, Nude / Mitogen-Activated Protein Kinase 3 / RNA, Messenger / Real-Time Polymerase Chain Reaction / Receptors, CXCR4 / Reverse Transcriptase Polymerase Chain Reaction / Salivary Gland Neoplasms / Tumor Cells, Cultured (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10585-012-9518-9 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22847686 ● Summary page in Scopus @ Elsevier: 2-s2.0-84875066432 (DOI: 10.1007/s10585-012-9518-9, PubMed: 22847686, Elsevier: Scopus)
68.	髙丸菜都美, 内田大亮, 大江剛, 永井宏和, 石丸直澄, 宮本洋二 : 下顎小臼歯部に発生した骨形成を伴う巨細胞エプーリスの1例, 日本口腔外科学会雑誌, Vol.58, No.11, 651-654, 2012年. (要約) Giant cell epulis (peripheral giant cell granuloma) is a granuloma consisting of a large number of multinucleated giant cells. Its incidence is high in Europe and the United States, but is very low in Japan. Giant cell epulis accompanied by bone formation is extremely rare in Japan. We report a case of giant cell epulis accompanied by bone formation. A 46-year-old woman visited our hospital because of a mass in the left mandibular molar region. There was a well-demarcated, pedunculated mass in the left mandibular molar region. The mass was excised under the clinical diagnosis of epulis. Histopathologically, the resected specimen consisted of spindle cells resembling fibroblasts and many multinucleated giant cells. Moreover, newly synthesized bone was observed in the center of the mass. The pathological diagnosis was a giant cell granuloma. Two years six months after the operation, there has been no evidence of recurrence. (キーワード) giant cell epulis(巨細胞エプーリス) / giant cell epulis(キョサイボウエプーリス) / bone formation(骨形成) / bone formation(ホネケイセイ) (出版サイトへのリンク) ● Publication site (DOI): 10.5794/jjoms.58.651 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282681509153536 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.58.651 (DOI: 10.5794/jjoms.58.651, CiNii: 1390282681509153536)
69.	Masako Fujioka-Kobayashi, Masato Ota, Asako Shimoda, Ken-ichi Nakahama, Kazunari Akiyoshi, Youji Miyamoto and Sachiko Iseki : Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering., Biomaterials, Vol.33, No.30, 7613-7620, 2012. (要約) To create a drug delivery system that allows the controlled release of proteins, such as growth factors, over a long-term period, cholesteryl group- and acryloyl group-bearing pullulan (CHPOA) nanogels were aggregated to form fast-degradable hydrogels (CHPOA/hydrogels) by cross-linking with thiol-bearing polyethylene glycol. The gold standard of clinical bone reconstruction therapy with a physiologically active material is treatment with recombinant human bone morphogenetic protein 2 (BMP2); however, this approach has limitations, such as inflammation, poor cost-efficiency, and varying interindividual susceptibility. In this study, two distinct growth factors, BMP2 and recombinant human fibroblast growth factor 18 (FGF18), were applied to a critical-size skull bone defect for bone repair by the CHPOA/hydrogel system. The CHPOA-FGF18/hydrogel displayed identical results to the control CHPOA-PBS/hydrogel, and the CHPOA-BMP2/hydrogel treatment imperfectly induced bone repair. By contrast, the CHPOA-FGF18 + BMP2/hydrogel treatment strongly enhanced and stabilized the BMP2-dependent bone repair, inducing osteoprogenitor cell infiltration inside and around the hydrogel. This report indicates that the CHPOA/hydrogel system can successfully deliver two different proteins to the bone defect to induce effective bone repair. The combination of the CHPOA/hydrogel system with the growth factors FGF18 and BMP2 might be a step towards efficient bone tissue engineering. (キーワード) Acrylates / Animals / Bone Morphogenetic Protein 2 / Bone Regeneration / Bone and Bones / Cell Lineage / コレステロール (cholesterol) / Drug Delivery Systems / Fibroblast Growth Factors / Glucans / Humans / Mice / Mice, Inbred C57BL / Osteoblasts / Polyethylene Glycols / Polyethyleneimine / Recombinant Proteins / Rhodamines / 再生医学 (tissue engineering) / Tomography, X-Ray Computed / Transforming Growth Factor beta / Wound Healing (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.biomaterials.2012.06.075 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22800537 ● Summary page in Scopus @ Elsevier: 2-s2.0-84864963987 (DOI: 10.1016/j.biomaterials.2012.06.075, PubMed: 22800537, Elsevier: Scopus)
70.	Chieko Sugawara, Akira Takahashi, Michiko Kubo, Hideki Otsuka, Naozumi Ishimaru, Youji Miyamoto and Eiichi Honda : Preoperative evaluation of patients with squamous cell carcinoma of the oral cavity: fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography and ultrasonography versus histopathology., Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol.114, No.4, 516-525, 2012. (要約) PET/CT and US are complementary tools to evaluate preoperative patients. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.oooo.2012.06.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22986248 ● Search Scopus @ Elsevier (PMID): 22986248 ● Search Scopus @ Elsevier (DOI): 10.1016/j.oooo.2012.06.004 (DOI: 10.1016/j.oooo.2012.06.004, PubMed: 22986248)
71.	Tetsuya Tamatani, Tarannum Ferdous, Natsumi Takamaru, Kanae Hara, Makoto Kinouchi, Nobuyuki Kuribayashi, Go Ohe, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : Antitumor efficacy of sequential treatment with docetaxel and 5-fluorouracil against human oral cancer cells, International Journal of Oncology, Vol.41, No.3, 1148-1156, 2012. (要約) Docetaxel (DOC) and 5-fluorouracil (5-FU) are important anticancer agents widely used in the treatment of a variety of cancers including oral squamous cell carcinoma (OSCC). The purpose of this study was to determine the antitumor efficacy of the sequential administration of DOC and 5-FU against OSCC cells (B88 and CAL27 cells) in vitro and in vivo. In in vitro growth inhibition assays, sequential treatment with DOC followed by 5-FU was more effective in inhibiting cancer cell growth than 5-FU followed by DOC, single treatment with DOC or 5-FU, or combined treatment with DOC and 5-FU. Furthermore, DOC followed by 5-FU significantly inhibited tumor growth in vivo compared to 5-FU followed by DOC. To understand the mechanisms underlying the enhanced growth inhibitory effect of the administration sequence, DOC followed by 5-FU, we examined the expression of 5-FU metabolic enzymes such as thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT), which were known to regulate the antitumor effect of 5-FU, by real-time RT-PCR and western blot analysis. Downregulation of TS and DPD expression and upregulation of OPRT expression were induced by DOC treatment, suggesting that DOC enhanced the efficacy of 5-FU by altering the expression of its metabolic enzymes. These results indicate that sequential treatment with DOC followed by 5-FU could be a promising therapeutic strategy for oral cancer. (キーワード) Animals / Antineoplastic Combined Chemotherapy Protocols / Cell Line, Tumor / Dihydrouracil Dehydrogenase (NADP) / Down-Regulation / Fluorouracil / Humans / Mice / Mice, Nude / Mouth Neoplasms / Orotate Phosphoribosyltransferase / Taxoids / Thymidylate Synthase / Up-Regulation / Xenograft Model Antitumor Assays (徳島大学機関リポジトリ) ● Metadata: 113602 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ijo.2012.1544 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22766915 ● Search Scopus @ Elsevier (PMID): 22766915 ● Search Scopus @ Elsevier (DOI): 10.3892/ijo.2012.1544 (徳島大学機関リポジトリ: 113602, DOI: 10.3892/ijo.2012.1544, PubMed: 22766915)
72.	Satoshi Hino, Hiroyuki Hamakawa, Youji Miyamoto, Kazuo Ryoke, Jyouji Sekine, Akira Sasaki, Tetsuya Yamamoto and The Oral Cancer Study Group Of Chugoku-shikoku : Effects of a concurrent chemoradiotherapy with S-1 for locally advanced oral cancer, Oncology Letters, Vol.2, No.5, 839-843, 2011. (要約) A number of regimens composed of concurrent chemoradiotherapy (CCRT) have been attempted as radical or adjuvant therapies for locally advanced oral cancer. CCRT with S-1 is considered promising due to its efficacy and simplicity of application. Patients (n=16) with locally advanced squamous cell carcinoma of the oral cavity were enrolled. Chemotherapy consisted of oral administration of S-1 (65 mg/m(2)) for 14 consecutive days followed by a 1-week rest. Radiation treatment at a dose of 30 Gy in 15 fractions was administered concomitantly with S-1. A course schedule of 3 weeks of treatment was applied twice. The overall response rate was 87.5%. Median progression-free survival and median overall survival were 6.3 and 42.5 months, respectively. Although no grade 4 adverse events were observed, grade 3 adverse events, such as anemia (12.5%), stomatitis (25%) and anorexia (18.8%) were present. Thus, CCRT with S-1 is an effective modality that can be safely conducted with minimal burden on patients. (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ol.2011.347 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22866137 ● Search Scopus @ Elsevier (PMID): 22866137 ● Search Scopus @ Elsevier (DOI): 10.3892/ol.2011.347 (DOI: 10.3892/ol.2011.347, PubMed: 22866137)
73.	永井宏和, 髙丸菜都美, 大江剛, 内田大亮, 玉谷哲也, 藤澤健司, 岩本誠司, 宮本洋二 : 口腔扁平上皮癌に対するS-1を併用したDocetaxel超選択的動注化学療法の臨床効果に関する研究, 癌と化学療法, Vol.38, No.5, 777-781, 2011年. (要約) The purpose of this study was to evaluate the effectiveness and adverse events of combination chemotherapy with oral S-1 administration following docetaxel(DOC)treatment by superselective intra-arterial infusion as neo-adjuvant chemotherapy (NAC)for patients with oral squamous cell carcinoma. Thirteen patients were enrolled in this study(9 men and 4 women, with a mean age of 61. 0 years). All patients were given S-1 65mg/m / 2 per day for 14 days, and DOC 40-50mg/m2 by intraarterial infusion was administered. The locoregional response evaluated 3 weeks after administration was 100%, including a 69. 2% complete response. According to Oboshi and Shimosato's classification, histological evaluation of surgical specimens revealed that 3 cases were Grade IIa, 4 cases Grade IIb, 1 case Grade IVa, and 4 cases Grade IVc. The severe side effects were neutropenia and cerebral infarction. The present study suggests that combination chemotherapy with S-1 and DOC by superselective intra-arterial infusion would be an effective and safe regimen in NAC for oral squamous cell carcinomas. (キーワード) Administration, Oral / Adult / Aged / Aged, 80 and over / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Squamous Cell / Cerebral Infarction / Drug Combinations / Female / Humans / Infusions, Intra-Arterial / Male / Middle Aged / Mouth Neoplasms / Neoplasm Staging / Neutropenia / Oxonic Acid / Taxoids / Tegafur (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21566436 ● Summary page in Scopus @ Elsevier: 2-s2.0-79960998915 (PubMed: 21566436, Elsevier: Scopus)
74.	Daisuke Uchida, Tomitaro Onoue, Nobuyuki Kuribayashi, Yoshifumi Tomizuka, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases., European Journal of Cancer, Vol.47, No.3, 452-459, 2011. (要約) We have previously demonstrated that a stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (OSCC). In this study, we investigated whether the blockade of CXCR4 inhibits lymph node metastasis in B88 OSCC cells. These cells harbour a functional CXCR4 and have the potential to metastasise to the lymph node in vivo. Following introduction of a vector that expresses short hairpin small interfering RNA (shRNA) against CXCR4, we isolated three clones (shCXCR4-16, -17 and -21) that showed decreased expression of CXCR4 mRNA. These clones also had reduced CXCR4 protein levels and showed impairments in calcium flux and cell migration in response to SDF-1. These cells were orthotopically inoculated into the masseter muscle of nude mice. Lymph node metastases, loss in body weight and tumour volumes were significantly inhibited in mice inoculated with shCXCR4-17 cells compared to mice inoculated with control cells. SDF-1-induced migration of B88 cells was significantly inhibited in vitro by the treatment with 1,1'-[1,4-phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane octahydrochloride (AMD3100), a CXCR4 antagonist. Subcutaneous administration of AMD3100 significantly inhibited the lymph node metastases of B88 cells when they were orthotopically inoculated into the masseter muscle of nude mice. Moreover, the enhanced production of interleukin (IL)-6 and IL-8 in response to SDF-1 was inhibited by shRNA against CXCR4 or by treatment with AMD3100. These results suggest that blockade of CXCR4 may be a potent anti-metastatic therapy against lymph node metastases in cases of CXCR4-related OSCC. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ejca.2010.09.028 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20965717 ● Search Scopus @ Elsevier (PMID): 20965717 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ejca.2010.09.028 (DOI: 10.1016/j.ejca.2010.09.028, PubMed: 20965717)
75.	Seiko Tatehara, Youji Miyamoto, Masaaki Takechi, Yukihiro Momota and Tetsuya Yuasa : Osteoporosis influences the early period of the healing after distraction osteogenesis in a rat osteoporotic model., Journal of Cranio-Maxillo-Facial Surgery, Vol.39, No.1, 2-9, 2010. (要約) Despite the clinical adoption of distraction osteogenesis (DO), studies examining the bone healing process at the distraction gap in osteoporotic bone are limited. We examined the effect of osteoporosis in the ovariectomized rat on DO. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jcms.2010.03.001 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20456966 ● Search Scopus @ Elsevier (PMID): 20456966 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jcms.2010.03.001 (DOI: 10.1016/j.jcms.2010.03.001, PubMed: 20456966)
76.	舘原誠晃, 藤澤健司, 永井宏和, 重本修伺, 大倉一夫, 石丸直澄, 林良夫, 宮本洋二 : 切除からインプラントを維持源としたエピテーゼまで一貫治療を行った上顎洞悪性線維性組織球腫の1例, 四国歯学会雑誌, Vol.22, No.2, 179-183, 2010年. (徳島大学機関リポジトリ) ● Metadata: 109796 (徳島大学機関リポジトリ: 109796)
77.	Daisuke Uchida, Tomitaro Onoue, Nasima-Mila Begum, Nobuyuki Kuribayashi, Yoshifumi Tomizuka, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cells., Molecular Cancer, Vol.8, 62, 2009. (要約) BACKGROUND: We have demonstrated that the stromal cell-derived factor-1 (SDF-1; CXCL12)/CXCR4 system is involved in the establishment of lymph node metastasis in oral squamous cell carcinoma (SCC). Chemotherapy is a powerful tool for the treatment of oral cancer, including oral SCC; however, the effects of chemotherapeutic agents on the expression of CXCR4 are unknown. In this study, we examined the expression of CXCR4 associated with the chemotherapeutic agents in oral cancer cells. RESULTS: The expression of CXCR4 was examined using 3 different chemotherapeutic agents; 5-fluorouracil, cisplatin, and vesnarinone (3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2-(1H)-quinolinone) in B88, a line of oral cancer cells that exhibits high levels of CXCR4 and lymph node metastatic potential. Of the 3 chemotherapeutic agents that we examined, only vesnarinone downregulated the expression of CXCR4 at the mRNA as well as the protein level. Vesnarinone significantly inhibited lymph node metastasis in tumor-bearing nude mice. Moreover, vesnarinone markedly inhibited 2.7-kb human CXCR4 promoter activity, and we identified the transcription factor, Krüppel-like factor 2 (KLF2), as a novel vesnarinone-responsive molecule, which was bound to the CXCR4 promoter at positions -300 to -167 relative to the transcription start site. The forced-expression of KLF2 led to the downregulation of CXCR4 mRNA and impaired CXCR4 promoter activity. The use of siRNA against KLF2 led to an upregulation of CXCR4 mRNA. CONCLUSION: These Results indicate that vesnarinone downregulates CXCR4 via the upregulation of KLF2 in oral cancer. (キーワード) Animals / Antineoplastic Agents / Cell Line, Tumor / Cell Movement / Cisplatin / Down-Regulation / Flow Cytometry / Fluorouracil / Gene Expression Regulation, Neoplastic / Hela Cells / Humans / Kruppel-Like Transcription Factors / Luciferases / Mice / Mice, Inbred BALB C / Mice, Nude / Mouth Neoplasms / Oligonucleotide Array Sequence Analysis / Promoter Regions, Genetic / Quinolines / RNA Interference / Receptors, CXCR4 / Reverse Transcriptase Polymerase Chain Reaction / Tumor Burden / Xenograft Model Antitumor Assays (出版サイトへのリンク) ● Publication site (DOI): 10.1186/1476-4598-8-62 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19671192 ● Search Scopus @ Elsevier (PMID): 19671192 ● Search Scopus @ Elsevier (DOI): 10.1186/1476-4598-8-62 (DOI: 10.1186/1476-4598-8-62, PubMed: 19671192)
78.	桃田幸弘, 里村一人, 湯淺哲也, 工藤景子, 高野栄之, 林良夫, 宮本洋二 : 著しい骨吸収を伴う歯性上顎洞炎の1例, 四国歯学会雑誌, Vol.21, No.2, 407-411, 2009年. (キーワード) 宮本
79.	藤澤健司, 舘原誠晃, 湯淺哲也, 桃田幸弘, 山内英嗣, 宮本洋二 : 即時荷重インプラントに関する臨床的検討:3年経過時の臨床成績 ., 日本口腔インプラント学会誌, Vol.21, No.4, 563-569, 2008年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205508947712 (CiNii: 1390001205508947712)
80.	藤澤健司, 山内英嗣, Seiko Takehara, 高野栄之, 湯淺哲也, 桃田幸弘, 宮本洋二 : 共鳴振動周波数分析装置を用いた即時荷重インプラント安定性の経時的評価, 日本顎顔面インプラント学会誌, Vol.7, No.3, 205-210, 2008年.
81.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Hideyuki Takano, Shiho Minamiguchi and Masaru Nagayama : Histological evaluation of apatite cement containing atelocollagen, Dental Materials Journal, Vol.26, No.2, 194-200, 2007. (要約) Tissue response to apatite cement (AC) containing atelocollagen (AC (ate)) was evaluated using conventional AC (c-AC) as a control material. At one week, the only difference between AC (ate) and c-AC was found in the soft tissue response. With c-AC, a moderate inflammatory response was exhibited: small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were aggregated around the scattered c-AC, whereas AC (ate) showed only a slight inflammatory response with few foreign body giant cells. In terms of bone tissue response, difference between AC (ate) and c-AC was observed at four weeks. New bone formation was observed along the cement at the edge of the pre-existing cortical bone in both c-AC and AC (ate). However, in the case of AC (ate), more abundant and thicker new bone was formed along the cement in the bone marrow when compared with c-AC. (キーワード) Animals / Bone Cements / Bone Regeneration / Bone and Bones / Cattle / Collagen / Foreign-Body Reaction / Hydroxyapatites / Male / Rats / Rats, Wistar / Subcutaneous Tissue / X-Ray Diffraction (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.26.194 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17621934 ● Search Scopus @ Elsevier (PMID): 17621934 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.26.194 (DOI: 10.4012/dmj.26.194, PubMed: 17621934)
82.	舘原誠晃, 武知正晃, 桃田幸弘, 湯浅哲也, 高野栄之, 徳山麗子, 宮本洋二, 長山勝 : HAP-PLGA複合体による顎骨再生への応用に関する実験的研究, 日本口腔外科学会雑誌, Vol.53, No.10, 588-593, 2007年. (キーワード) *Hydroxyapatite
83.	成田王彦, 今政幸, 永井宏和, 福田雅幸, 田中清志, 福士省治, 五十嵐淳子, 宮本洋二 : 硫酸カリウム水溶液による急速加熱型クリストバライト埋没材の鋳型放置時間の短縮, --- -クラウン適合精度, 硬化膨張, 加熱膨張に及ぼす影響- ---, 日本歯科技工学会雑誌, Vol.27, No.2, 115-120, 2006年. (キーワード) potassium sulfate / setting time / setting expansion / thermal expansion / size accuracy (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1570854175412706048 (CiNii: 1570854175412706048)
84.	永井宏和, 中田憲, 畠山成知, 福田雅幸, 南條博, 宮本洋二 : 頬部に生じた孤立性神経線維腫の1例, 日本口腔外科学会雑誌, Vol.52, No.11, 592-595, 2006年. (要約) Neurofibroma is a benign tumor originating from Schwann cells, perineural fibroblasts, or both. It is commonly associated with neurofibromatosis (von Recklinghausen's disease), while solitary neurofibroma rarely occurs in the oral region. We report a rare case of solitary neurofibroma arising in the cheek. The patient was a 47-year-old woman who had no symptoms, except for a painless swelling in the right side of the cheek. We found neither cafe-au-lait spots nor tumors on the skin of her body. Intraoral examination revealed a solitary, mobile, welldelimited, elastic soft mass 25 mm in diameter in the cheek. CT scan revealed an enhanced tumor mass in the cheek. The tumor was surgically removed. Histopathologically, it was composed of proliferating spindle cells and collagen-like fibers. Immunohistochemical studies showed positive staining of tumor cells with S-100 protein. The histopathological diagnosis was neurofibroma. About 12 months after the operation, there is no evidence of recurrence. (キーワード) neurofibroma / solitary / cheek (出版サイトへのリンク) ● Publication site (DOI): 10.5794/jjoms.52.592 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282681510124416 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.52.592 (DOI: 10.5794/jjoms.52.592, CiNii: 1390282681510124416)
85.	Takayoshi Ohnuki, Masayuki Fukuda, Akira Nakata, Hirokazu Nagai, Tetsuyuki Takahashi, Takashi Sasano and Youji Miyamoto : Evaluation of the position, mobility, and morphology of the disc by MRI before and after four different treatments for temporomandibular joint disorders., Dento Maxillo Facial Radiology, Vol.35, No.2, 103-109, 2006. (要約) The purpose of this study was to evaluate changes in disc position, mobility, and morphology in patients with temporomandibular joint disorders (TMD) in response to four different treatments, splint therapy, pumping manipulation, arthrocentesis, and arthroscopic surgery, using magnetic resonance imaging (MRI). Eighty-five joints (85 patients) with unilateral internal derangement or osteoarthritis that were successfully treated were included in this study. The patients were divided into four groups as follows: splint therapy group, pumping manipulation group, arthrocentesis group, and arthroscopic surgery group. Changes in the disc position, mobility, and morphology before and after treatment were compared among the four groups using MRI. All discs showed anterior disc displacement (ADD) without reduction before treatment. Only 10% of the joints became ADD with reduction after treatment, and the other joints remained ADD without reduction in spite of treatment. Discs treated by arthroscopic surgery were located more anteriorly compared with pre-treatment. In pre-treatment MRI, the rate of stuck disc increased as the stage of the treatment advanced. In post-treatment MRI, all temporomandibular joints (TMJs) had mobile discs. The disc deformity advanced after arthrocentesis and arthroscopic surgery. Even though clinical signs and symptoms were alleviated by treatment, most discs remained ADD without reduction on MRI in spite of treatment. This suggests that the four treatments do not necessarily improve the position and deformity of the disc, and that arthroscopic surgery advances the deformity and anterior displacement of the disc. Disc mobility is important for improving clinical signs and symptoms. (キーワード) Adolescent / Adult / Aged / Arthroscopy / Dislocations / Female / Follow-Up Studies / Humans / 磁気共鳴映像法 (magnetic resonance imaging) / Male / Manipulation, Orthopedic / Middle Aged / Occlusal Splints / Osteoarthritis / Paracentesis / Range of Motion, Articular / Temporomandibular Joint Disc / Temporomandibular Joint Disorders (出版サイトへのリンク) ● Publication site (DOI): 10.1259/dmfr/25020275 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16549437 ● Summary page in Scopus @ Elsevier: 2-s2.0-33645324023 (DOI: 10.1259/dmfr/25020275, PubMed: 16549437, Elsevier: Scopus)
86.	Takahiro Otani, Noriaki Tomura, Koumei Narita, Satoshi Takahashi, Ikuo Sakuma, Kaku Yasuda, Jiro Watarai, Takayoshi Ohnuki and Youji Miyamoto : Serial contrast-enhanced MRI of the dondyle and posterior disk attachment for assessing temporomandibular joint disorders, Akita Journal of Medicine, Vol.32, No.3-4, 175-186, 2006.
87.	Hirokazu Nagai, Youji Miyamoto, Akira Nakata, Shigetomo Hatakeyama, Yoichi Iwanami and Masayuki Fukuda : Isolation and characterization of synovial cells from the human temporomandibular joint., Journal of Oral Pathology & Medicine, Vol.35, No.2, 104-110, 2006. (要約) The synovial tissues with temporomandibular disorders (TMDs) often show chronic inflammatory changes and the synovial cells participate in the pathogenic processes of TMDs. The synovial membrane is composed of a synovial lining layer and a connective sublining layer. The synovial lining layer is made up of two kinds of cells: macrophage-like type A and fibroblastic type B cells. The aim of this study was to isolate and characterize synovial cells from the human temporomandibular joint (TMJ). (キーワード) Antigens, CD / Antigens, Differentiation, Myelomonocytic / Biological Markers / 細胞分離 (cell separation) / Cells, Cultured / Connective Tissue Cells / Fibroblasts / Heat-Shock Proteins / Humans / 免疫組織化学 (immunohistochemistry) / Laminin / Macrophages / Phenotype / Procollagen-Proline Dioxygenase / Synovial Membrane / 顎関節 (temporomandibular joint) / Vimentin (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1600-0714.2006.00369.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16430741 ● Search Scopus @ Elsevier (PMID): 16430741 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0714.2006.00369.x (DOI: 10.1111/j.1600-0714.2006.00369.x, PubMed: 16430741)
88.	成田王彦, 今政幸, 田中清志, 永井宏和, 福田雅幸, 福士省冶, 五十嵐淳子, 宮本洋二 : 硫酸カリウム水溶液による急速加熱型クリストバライト埋没材の鋳型放置時間の短縮クラウン適合精度，硬化膨張，加熱膨張に及ぼす影響, 日本歯科技工学会雑誌, Vol.27, No.2, 115-120, 2006年.
89.	三好康太郎, 大貫敬嘉, 永井宏和, 武蔵哲貞, 柏木了, 福田雅幸, 宮本洋二 : 下顎枝矢状分割術を施行した外科的矯正治療前後における顎関節MRI所見の変化, 日本顎関節学会雑誌, Vol.17, No.3, 224-231, 2005年. (キーワード) MRI所見 / 外科的矯正治療 / 下顎枝矢状分割術 / 顎関節 (temporomandibular joint) (出版サイトへのリンク) ● Publication site (DOI): 10.11246/gakukansetsu1989.17.224 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204420886912 ● Search Scopus @ Elsevier (DOI): 10.11246/gakukansetsu1989.17.224 (DOI: 10.11246/gakukansetsu1989.17.224, CiNii: 1390001204420886912)
90.	山岡薫, Masayuki Fukuda, Shigetomo Hatakeyama, Daigo Murayama, Ryo Kashiwagi, Tetsusada Musashi, Takayoshi Ohnuki, Kotaro Miyoshi, 永井宏和, Hiroshi Nanjo, 宮本洋二 : 口腔扁平上皮癌に対するDocetaxelとNedaplatin併用療法の臨床的検討, 癌と化学療法, Vol.32, No.10, 1411-1414, 2005年. (要約) The purpose of this study was to evaluate the effectiveness and safety of combination chemotherapy with docetaxel (TXT) and nedaplatin (CDGP) for patients with oral squamous cell carcinomas. Eight patients were enrolled in this study (4 men and 4 women, with a mean age of 61.7 years). TXT and CDGP were administered at a dose of 60 mg/m(2) and 70 mg/m(2) by drip infusion for 120 minutes, respectively. Three patients received one more administration 4 weeks after the first one. The locoregional response was evaluated 4 weeks after the final administration of TXT and CDGP. As a result, the locoregional response rate after 1 course was 62.5% including 25.0% of complete response (CR). The response rate after 2 courses was 100.0% with 66.7% of CR. According to Oboshi and Shimosato's classification, histological evaluation of surgical specimens revealed that four cases were Grade IIa, two cases Grade IIb, and two cases Grade IV. The severe adverse events were neutropenia and leukopenia, which were effectively managed with granulocyte colony-stimulating factor (G-CSF). No other severe side effects were recognized. The present study suggested that the combination chemotherapy with TXT and CDGP would be an effective and safe regimen in neo-adjuvant chemotherapy for oral squamous cell carcinomas. (キーワード) Adult / Aged / Alopecia / Antineoplastic Combined Chemotherapy Protocols / Carcinoma, Squamous Cell / Chemotherapy, Adjuvant / Drug Administration Schedule / Female / Granulocyte Colony-Stimulating Factor / Humans / Leukopenia / Male / Middle Aged / Mouth Neoplasms / Neoplasm Staging / Neutropenia / Organoplatinum Compounds / Taxoids (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16227739 ● Summary page in Scopus @ Elsevier: 2-s2.0-27744485118 (PubMed: 16227739, Elsevier: Scopus)
91.	藤澤健司, 宮本洋二, 桃田幸弘, 日比弓紀子, 長山勝 : インプラントの安定性評価における共鳴振動周波数分析装置と歯牙動揺度測定装置の比較, 日本口腔インプラント学会誌, Vol.18, No.3, 406-414, 2005年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205506100608 (CiNii: 1390001205506100608)
92.	山岡薫, 福田雅幸, 大貫敬嘉, 三好康太郎, 永井宏和, 面川進, 宮本洋二 : 上顎骨切り術(Le Fort I型骨切り術)における貯血式自己血輸血の有用性に関する検討, 自己血輸血, Vol.18, No.1, 79-83, 2005年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1573105975220424192 (CiNii: 1573105975220424192)
93.	田中清志, 福田雅幸, 神谷修, 成田王彦, 宮本洋二 : 顎義歯支持におけるインプラント体の配置に関する研究:ストレート型埋入モデルとアーチ型埋入モデルとの比較, 日本歯技, No.435, 33-40, 2005年.
94.	村山大悟, 永井宏和, 戸嶋慎一, 福田雅幸, 小野寺健, 宮本洋二 : 高齢者の下顎に発生した顎骨中心性神経鞘腫の1例, 日本口腔科学会雑誌, Vol.54, No.3, 368-372, 2005年. (キーワード) Schwannoma / Mandible / 下顎骨 / Elderly patient (出版サイトへのリンク) ● Publication site (DOI): 10.11277/stomatology1952.54.368 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282681412308224 ● Search Scopus @ Elsevier (DOI): 10.11277/stomatology1952.54.368 (DOI: 10.11277/stomatology1952.54.368, CiNii: 1390282681412308224)
95.	福田雅幸, 宮本洋二, 武蔵哲貞, 大貫敬嘉, 永井宏和 : チタンメッシュトレーと腸骨骨髄海綿骨細片移植による下顎骨再建後のインプラント義歯の機能評価, 日本口腔インプラント学会誌, Vol.18, No.2, 302-309, 2005年. (キーワード) dental implant / mandibular reconstruction / particulate cancellous bone and marrow graft / segmental defect / titanium mesh tray (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205506693888 (CiNii: 1390001205506693888)
96.	宮本洋二, 藤澤健司, 福田雅幸, 湯淺哲也, 長山勝, 山内英嗣, 河野文昭, 日野出大輔 : 即時荷重インプラントに関する臨床的検討: 臨床術式と1年経過時の臨床成績, 日本口腔インプラント学会誌, Vol.18, No.2, 292-301, 2005年. (キーワード) dental implant / early loading / immediate loading / load (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571135650275179904 (CiNii: 1571135650275179904)
97.	成田王彦, 宮本洋二, 今政幸, 田中清志, 神谷修 : 硫酸カリウム水溶液による急速加熱型クリストバライト埋没材の鋳型放置時間短縮の試み, 日本歯科技工学会雑誌, Vol.26, No.1, 16-20, 2005年. (キーワード) 硬化時間 / 硬化促進剤 / 寸法精度 / 埋没材 / 硫酸カリウム (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571417125213049344 (CiNii: 1571417125213049344)
98.	田中清志, 宮本洋二, 成田王彦, 飯野光喜, 福田雅幸 : 新しい外鼻矯正装置付口蓋床の作製法と臨床応用, 日本歯科技工学会雑誌, Vol.26, No.1, 89-93, 2005年.
99.	Tetsuya Yuasa, Youji Miyamoto, Masayuki Kon, Kunio Ishikawa, Masaaki Takechi, Yukihiro Momota, Seiko Tatehara, Hideyuki Takano, Shiro Minamiguchi and Masaru Nagayama : Proliferation and Differentiation of Cultured MC3T3-E1 Osteoblasts on Surface-layer Modified Hydroxyapatite Ceramic with Acid and Heat Treatments, Dental Materials Journal, Vol.24, No.2, 207-212, 2005. (要約) Effects of functionally gradient calcium phosphate consisting of hydroxyapatite (HAP) and alpha-tricalcium phosphate (alpha-TCP) on proliferation and differentiation of osteoblasts were evaluated using MC3T3-E1 cells. There were no significant differences in the proliferation of MC3T3-E1 cells among HAP-alpha-TCP functionally gradient calcium phosphate, pure HAP, and cell culture plastic wells. mRNA expressions of type I collagen, alkaline phosphate, and osteocalcine were evaluated as indexes of initial; mid-stage, and late-stage osteoblastic differentiation. Basically, HAP-alpha-TCP functionally gradient calcium phosphate and pure HAP enhanced the expressions of the three markers when compared with that of cell culture plastic wells. For type I collagen and alkaline phosphate expressions, HAP-alpha-TCP functionally gradient calcium phosphate showed the same expression level as pure HAP. For osteocalcine expression, HAP-alpha-TCP functionally gradient calcium phosphate showed a higher level than pure HAP. We concluded, therefore, HAP-alpha-TCP functionally gradient calcium phosphate has good potential to be a bone filler material with high osteoconductivity. (キーワード) Osteoblasts / α-tricalcium phosphate / ハイドロキシアパタイト (hydroxyapatite) (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.24.207 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16022440 ● Search Scopus @ Elsevier (PMID): 16022440 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.24.207 (DOI: 10.4012/dmj.24.207, PubMed: 16022440)
100.	Masayuki Kon, Mayumi Luciana Hirakata, Youji Miyamoto, H Kasahara and Kenzo Asaoka : Strengthening of calcium phosphate cement by compounding calcium carbonate whiskers, Dental Materials Journal, Vol.24, No.1, 104-110, 2005. (要約) The purpose of this study was to investigate how aragonite (calcium carbonate) whiskers influenced the strengthening and carbonating of alpha-tricalcium phosphate (alpha-TCP) based calcium phosphate cement. Aragonite whiskers of 0.95 microm width with an aspect ratio of 6.6 were prepared. The cement powder, alpha-TCP containing 0-50 mass% aragonite whisker, was mixed with 0.6 mol/L NaH2PO4 solution and incubated at 37 degrees C and 100% relative humidity. Diametral tensile strength (DTS) value increased significantly when appropriate amount of aragonaite whiskers was added. For example, DTS value of set cement containing 20 mass% aragonite whisker was 5.8 +/- 0.5 MPa, whereas DTS value of set cement containing no whiskers was 1.3 +/- 0.2 MPa after 1-week incubation. SEM observation revealed that the shape of the whiskers and the densification of the structure could have contributed to the strengthening of the set cement. Moreover, FTIR spectra implied that a bone-like carbonated apatite was precipitated in the cement. The results obtained in the present study revealed that the shape as well as any slight dissolution of aragonite whiskers could contribute to improving the properties of a-TCP based calcium phosphate cement. (キーワード) Apatites / Calcium Carbonate / Calcium Phosphates / Carbon / Crystallography, X-Ray / Dental Cements / Dental Stress Analysis / Materials Testing / Microscopy, Electron, Scanning / Spectroscopy, Fourier Transform Infrared / Tensile Strength (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.24.104 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15881216 ● Summary page in Scopus @ Elsevier: 2-s2.0-20644468599 (DOI: 10.4012/dmj.24.104, PubMed: 15881216, Elsevier: Scopus)
101.	山岡薫, 福田雅幸, 大貫敬嘉, 三好康太郎, 永井宏和, 面川進, 宮本洋二 : 上顎骨切り術(Le Fort I型骨切り術)における貯血式自己血輸血の有用性に関する検討, 自己血輸血, Vol.18, No.1, 79-83, 2005年.
102.	福田雅幸, 宮本洋二, 飯野光喜, 幸地省子 : 常温重合型粘弾性レジンを用いた小型鼻口腔瘻栓塞子, 日本口蓋裂学会雑誌, Vol.29, No.3, 322-324, 2004年. (キーワード) oronasal fistula / obturator / self-curing viscoelastic resin (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680429996544 (CiNii: 1390282680429996544)
103.	宮本洋二, 藤澤健司, 住友孝史, 湯淺哲也, 長山勝, 山内英嗣, 河野文昭, 日野出大輔 : インプラントの表面性状がオッセオインテグレーション獲得に及ぼす影響, --- 滑面と粗面(陽極酸化面)フィクスチャーの比較 ---, 日本口腔インプラント学会誌, Vol.17, No.2, 216-226, 2004年. (キーワード) dental implant / early failure / osseointegration / prognosis / surface roughness (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680487133824 (CiNii: 1390282680487133824)
104.	湯淺哲也, 宮本洋二, 中西宏彰, 藤澤健司, 舘原誠晃, 瀧雅行, 長山勝 : 顔面多発骨折の変形治療に対し顎矯正手術および骨移植術により形態·機能を改善した1例, 口腔顎顔面外傷, Vol.3, No.1, 26-31, 2004年. (キーワード) 顎矯正手術 / 顔面多発骨折後の変形治癒 / 咬合平面板
105.	山之内浩司, 鎌田伸之, 宮本洋二, 桃田幸弘, 北岡栄一郎 : 舌体部へのピアス迷入の1例, 日本口腔外科学会雑誌, Vol.50, No.4, 255-258, 2004年. (要約) Body piercing is becoming more popular. Increasing popularity of tongue piercing has led to a rise in infectious complications and secondary metal allergy. We report a rare case of a deeply impacted metal barbelltype pierced ornament into the tongue.<BR>A 19-year-old man was referred to our hospital by a general practitioner bacause of discomfort of the tongue and difficulty in eating. The patient had a slight swelling of the tongue. Physical examination revealed a hard mass in the body of the tongue. Mandibular occlusal radiographs showed a radiopaque body measuring about 3×3mm in the center of the tongue. The clinical diagnosis was a foreign body in the tongue. The foreign body was removed surgically under local anesthesia. We performed element analysis of the removed foreign body. The patient's progress has been good, without functional disorders of the tongue. (キーワード) tongue pierce / foreign body / element analysis (出版サイトへのリンク) ● Publication site (DOI): 10.5794/jjoms.50.255 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001206530515712 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.50.255 (DOI: 10.5794/jjoms.50.255, CiNii: 1390001206530515712)
106.	Masaaki Takechi, Youji Miyamoto, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama and Kunio Ishikawa : Effects of various sterilization methods on the setting and mechanical properties of apatite cement, Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.69B, No.1, 58-63, 2004. (要約) Sterilization capability is a necessary requirement for any material that is to be used in a medical application. Therefore, it is necessary for apatite cement (AC) to be sterilized. Because there is little information on the sterilization methods of AC, the aims of this investigation were to evaluate the effects of various sterilization methods, including steam, dry heat, ethylene oxide (EtO) gas, and gamma irradiation sterilizations, on the setting and mechanical properties of AC. In the case of steam sterilization, because AC powder aggregated before setting-time measurements, the setting time could not be measured. When the powder was sterilized by dry heat or EtO gas, the setting time was prolonged significantly and the wet diametral tensile strength (DTS) value decreased significantly. Therefore, sterilizations with steam, dry heat, or EtO gas were suggested to be inappropriate methods for AC. Accordingly, the following experiments focused on gamma sterilization. The setting time of AC was retarded with an increase in gamma irradiation dose. The wet DTS value decreased with the increase in gamma irradiation dose. There was no compositional change due to the gamma irradiation. The following tests were carried out in order to examine the effect of the gamma irradiation on the setting reaction of AC in detail. Tetracalcium phosphate [TTCP: Ca(4)(PO(4))(2)O] and dicalcium phosphate anhydrous (DCPA: CaHPO(4)) were separately irradiated, and the cements were produced with the use of irradiated powder and nonirradiated powder. Although the wet DTS value of AC produced from irradiated TTCP and nonirradiated DCPA decreased with increasing gamma irradiation dose, there was no significant difference. In contrast, the wet DTS value of AC produced from irradiated DCPA and nonirradiated TTCP significantly decreased with the increase in gamma irradiation dose. In conclusion, although the detailed mechanism of the delayed setting time and decreased DTS value was not clarified by the present study, it was found that gamma irradiation affected DCPA more than TTCP. (キーワード) apatite / apatite cement / mechanical properties / gamma / sterilization (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.b.10031 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15015210 ● Search Scopus @ Elsevier (PMID): 15015210 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.10031 (DOI: 10.1002/jbm.b.10031, PubMed: 15015210)
107.	Yukihiro Momota, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara and Masaru Nagayama : Effects of neutral sodium hydrogen phosphate on the setting property and hemostatic ability of hydroxyapatite putty as a local hemostatic agent for bone, Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.69B, No.1, 99-103, 2004. (要約) Hydroxyapatite (HAP) putty has been reported to have good hemostatic ability and excellent biocompatibility. Although the setting reaction of HAP putty and resulting transformation to HAP is the reason for this excellent biocompatibility, it also limits the handling period. In this study, the relationship between the setting reaction of HAP putty and its hemostatic ability was investigated, where neutral sodium hydrogen phosphate concentration and post-preparation time were used as indexes. A higher concentration of neutral sodium hydrogen phosphate was found to result in decreased hemostatic ability. The hemostatic ability of HAP putty decreased with time after its preparation; thus it was important to use HAP putty within 10 min after its preparation. The adhesive strength of HAP putty to bone increased with time. Therefore reliable hemostasis can be expected with HAP putty. Although the limited handling time is a drawback, HAP putty is thought to have a good potential as a hemostatic agent-it is highly reliable, and has a high hemostatic ability with excellent biocompatibility. (キーワード) hemostatic agents / hydroxyapatite putty / apatite cement / calcium- phosphate cement / setting reaction (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.b.20034 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15015217 ● Search Scopus @ Elsevier (PMID): 15015217 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.b.20034 (DOI: 10.1002/jbm.b.20034, PubMed: 15015217)
108.	Tetsuya Yuasa, Youji Miyamoto, Kunio Ishikiawa, Masaaki Takechi, Yukihiro Momota, Seiko Tatehara and Masaru Nagayama : Effects of apatite cements on proliferation and differentiation of human osteoblasts in vitro, Biomaterials, Vol.25, No.7-8, 1159-1166, 2004. (要約) Although apatite cement (AC) and sintered hydroxyapatite (s-HAP) are known to show good osteoconductivity, it is not clear whether or not the degree of their osteoconductivity is the same. In addition, it has not been clarified whether or not it is dependent on the type of AC; conventional AC (c-AC), fast-setting AC (fs-AC) or anti-washout AC (aw-AC). The aim of this study was to investigate the effects of ACs on cultured human osteoblasts, as they may provide a useful index of osteoconductivity. Human osteoblasts were cultured on the surfaces of ACs and s-HAP, and were evaluated with respect to cell attachment, proliferation, and differentiation. We found that ACs and s-HAP showed similar cell attachment. No significant difference between ACs and s-HAP was found with respect to the proliferation of osteoblasts. In contrast, we found that the differentiation of osteoblasts was enhanced on the surface of ACs compared with that of s-HAP. However, there was no difference among the types of AC. We therefore concluded that AC may show better osteoconductivity than s-HAP, and that osteoconductivity of AC may be similar, regardless of the type of AC. (キーワード) Biocompatible Materials / Bone Cements / Cell Adhesion / 細胞分化 (cell differentiation) / 細胞分裂 (cell division) / Cells, Cultured / Humans / Hydroxyapatites / Materials Testing / Molecular Conformation / Osseointegration / Osteoblasts (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.biomaterials.2003.08.003 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14643589 ● CiNii @ 国立情報学研究所 (CRID): 1572261551649164288 ● Search Scopus @ Elsevier (PMID): 14643589 ● Search Scopus @ Elsevier (DOI): 10.1016/j.biomaterials.2003.08.003 (DOI: 10.1016/j.biomaterials.2003.08.003, PubMed: 14643589, CiNii: 1572261551649164288)
109.	Ken'ichi Yokoyama, Kazuyuki Kaneko, Youji Miyamoto, Kenzo Asaoka, Jun'ichi Sakai and Michihiko Nagumo : Fracture associated with hydrogen absorption of sustained tensile-loaded titanium in acid and neutral fluoride solutions, Journal of Biomedical Materials Research. Part A, Vol.68, No.1, 150-158, 2004. (要約) The fracture of commercial pure titanium in acid and neutral fluoride solutions has been examined by a sustained tensile-loading test and hydrogen thermal desorption analysis. It was found that the fracture of titanium occurred in neutral 2.0% NaF solution as well as in 2.0% acidulated phosphate fluoride (APF) solution. The time to fracture decreased with increasing applied stress in both 2.0% APF and 2.0% NaF solutions. In the case of the same applied stress, the time to fracture in the 2.0% APF solution was shorter than that in the 2.0% NaF solution. General corrosion was exhibited on the side surface of the tested specimens. The formation of sodium titanium fluoride was observed on the surface of the immersed specimens in the 2.0% APF solution. Hydrogen desorption of the tested specimen in the 2.0% APF solution was observed with a peak at approximately 600 degrees C. The amount of absorbed hydrogen was >300 mass ppm in the 2.0% APF solution under an applied stress for 24 h. The results of the present study imply that applying stress to titanium by immersing in fluoride solutions leads to the degradation of its mechanical properties. (キーワード) titanium / fracture / hydrogen embrittlement / corrosion / fluoride / STRESS-CORROSION CRACKING / TI SUPERELASTIC ALLOY / PURE TITANIUM / CATHODIC POLARIZATION / HYDROCHLORIC-ACID / HYDRIDE FORMATION / HOLLOW IMPLANTS / EMBRITTLEMENT / RESISTANCE / BEHAVIOR (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.a.20067 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14661260 ● Search Scopus @ Elsevier (PMID): 14661260 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.a.20067 (DOI: 10.1002/jbm.a.20067, PubMed: 14661260)
110.	藤澤健司, 横山和博, 宮本洋二, 鎌田伸之, 長山勝 : 薬物療法を行った顎関節症患者の臨床的検討, 日本顎関節学会雑誌, Vol.15, No.3, 260-265, 2003年. (キーワード) TMD patients / drug therapy / clinical study (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001204420398464 (CiNii: 1390001204420398464)
111.	Youji Miyamoto, Kenji Fujisawa, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama and Eiji Yamauchi : Effect of the additional installation of implants in the posterior region on the prognosis of treatment in the edentulous mandibular jaw, Clinical Oral Implants Research, Vol.14, No.6, 727-733, 2003. (要約) The aim of this study was to elucidate the effect of the additional installation of implants in the posterior region on the prognosis of treatment in the edentulous mandibular jaw. Fifteen patients who had received implants (Brånemark system, Nobel Biocare, Gotebörg, Sweden) in the edentulous mandible and completed a 1-year follow-up after the fitting of implant-anchored fixed prostheses were selected. In seven patients (Group A), four or five implants were installed between the mental foramina, and in eight patients (Group P), one or two implants, one on each side, were installed in the posterior regions in addition to the implants between the foramina. All implants of both groups achieved osseointegration. In Group A, there was no implant loss after loading. Six implants were lost in five patients of Group P within 1 year after loading. All of them were located in the posterior region. To elucidate whether or not the failure rate of the implants in the posterior region of Group P after loading was especially high, the failures were also compared with 89 implants, which were installed in the posterior region of the mandibles to support implant-anchored fixed partial prosthesis, during the same period (Group C). The cumulative survival rate of the implants of Group P was 60%, while that of the implants of Group C was 100% (P<0.001). When the survival rates of posterior implants with the same length of the two groups were compared, there were significant differences for the 7- and 10-mm-length implants only. These data demonstrate that the posterior implants in Group P are at greater risk. Deformation of the mandible due to jaw movement was thought to be the most likely cause of the implant loss. Therefore, when such modified treatment is chosen, it should be performed with meticulous attention. (キーワード) fully edentulous mandible / deformation / failure / distortion (出版サイトへのリンク) ● Publication site (DOI): 10.1046/j.0905-7161.2003.00958.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15015949 ● Search Scopus @ Elsevier (PMID): 15015949 ● Search Scopus @ Elsevier (DOI): 10.1046/j.0905-7161.2003.00958.x (DOI: 10.1046/j.0905-7161.2003.00958.x, PubMed: 15015949)
112.	Kenji Fujisawa, Youji Miyamoto and Masaru Nagayama : Basic fibroblast growth factor and epidermal growth factor reverse impaired ulcer healing of the rabbit oral mucosa, Journal of Oral Pathology & Medicine, Vol.32, No.6, 358-366, 2003. (キーワード) bFGF / EGF / impaired ulcer healing / oral mucosa / wound healing / FACTOR-BETA / DESALIVATED RATS / TISSUE-REPAIR / WOUNDS / MODEL / EXPRESSION / SALIVA / MICE (出版サイトへのリンク) ● Publication site (DOI): 10.1034/j.1600-0714.2003.t01-1-00111.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12787043 ● Search Scopus @ Elsevier (PMID): 12787043 ● Search Scopus @ Elsevier (DOI): 10.1034/j.1600-0714.2003.t01-1-00111.x (DOI: 10.1034/j.1600-0714.2003.t01-1-00111.x, PubMed: 12787043)
113.	宮本洋二, 藤澤健司, 湯淺哲也, 桃田幸弘, 長山勝, 山内英嗣, 坂東永一, 日野出大輔 : 歯科インプラントのオッセオインテグレーション喪失に関与するリスクファクターの検討, 日本口腔インプラント学会誌, Vol.16, No.2, 278-288, 2003年. (キーワード) dental implant / late failure / osseointegration / clinical factor / risk factor (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205509924608 (CiNii: 1390001205509924608)
114.	宮本洋二, 舘原誠晃, 藤澤健司, 北岡栄一郎, 湯淺哲也, 鎌田伸之, 長山勝, 山内英嗣 : 垂直的歯槽骨延長と即時荷重インプラントによって機能回復を図った外傷性歯槽骨欠損の1例, 日本口腔顎顔面外傷雑誌, Vol.22, No.1, 15-21, 2003年. (キーワード) 骨延長 / 歯槽骨増生 / 即時荷重インプラント
115.	藤澤健司, 住友孝史, 舘原誠晃, 宮本洋二, 鎌田伸之, 長山勝 : 下顎骨関節突起骨折の臨床的検討, 日本顎関節学会雑誌, Vol.15, No.1, 18-23, 2003年. (キーワード) 関節突起骨折 / 臨床的検討 / 予後 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282679397933440 (CiNii: 1390282679397933440)
116.	舘原誠晃, 宮本洋二, 藤澤健司, 武知正晃, 桃田幸弘, 湯淺哲也, 長山勝, 山内英嗣 : 垂直的歯槽骨延長におけるインプラント型骨延長器の使用経験, 日本口腔インプラント学会誌, Vol.16, No.1, 91-96, 2003年. (キーワード) distractor / distraction osteogenesis / alveolar ridge angmentation / osseointegrated implant
117.	佐竹秀太, 高木豊明, 堀内信也, 横関雅彦, 藤澤健司, 宮本洋二, 伊賀弘起, 吉田秀夫, 長山勝, 佐藤光信, 森山啓司 : 徳島大学歯学部附属病院矯正歯科における顎変形症患者の臨床統計学的検討, 四国歯学会雑誌, Vol.15, No.2, 257-262, 2003年.
118.	藤澤健司, 宮本洋二, 鎌田伸之, 長山勝, 松本文博 : クローズドロックに対するパンピング·マニピュレーション，上関節腔洗浄療法について, 四国歯学会雑誌, Vol.15, No.2, 243-250, 2003年.
119.	宮本洋二, 藤澤健司, 武知正晃, 桃田幸弘, 長山勝, 山内英嗣, 坂東永一, 日野出大輔 : 歯科インプラントのオッセオインテグレーション獲得に関与する臨床的要因の検討, 日本口腔インプラント学会誌, Vol.15, No.4, 436-445, 2002年. (キーワード) dental implant / early failure / osseointegration / clinical factor (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680486990592 (CiNii: 1390282680486990592)
120.	Masaaki Takechi, Youji Miyamoto, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama, Kunio Ishikawa and Kasuomi Suzuki : The in vitro antibiotic release from anti-washout apatite cement using chitosan, Journal of Materials Science. Materials in Medicine, Vol.13, No.10, 973-978, 2002. (要約) The in vitro antibiotic release from anti-washout apatite cement using chitosan (aw-AC(chi)) was investigated in a preliminary evaluation. Flomoxef sodium was employed as the antibiotic and was incorporated into the powder phase aw-AC(chi) at up to 10%. The setting times were measured for aw-AC(chi) containing various amounts of flomoxef sodium. X-ray diffraction (XRD) analysis was also conducted for the identification of products. To evaluate the drug release profile, set aw-AC was immersed in saline and the released flomoxef sodium was determined at regular intervals. The setting time was prolonged slightly with the addition of flomoxef sodium. The difference at 10% flomoxef sodium (0% vs. 10%) was not significant (p>0.05), and can be negligible in clinic. The XRD analysis revealed that formation of hydroxyapatite (HAP) from aw-AC(chi) was reduced, even after 24 h, when the aw-AC(chi) contained flomoxef sodium at 8% or more. The flomoxef sodium release from aw-AC(chi) showed the typical profile observed in skeleton type drug delivery system (DDS). Changing the concentration of chitosan can control the rate of drug release from aw-AC. Therefore, we conclude that aw-AC(chi) is a good candidate for potential use as a DDS carrier that may be useful in surgical operations. (出版サイトへのリンク) ● Publication site (DOI): 10.1023/A:1019816830793 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15348192 ● Search Scopus @ Elsevier (PMID): 15348192 ● Search Scopus @ Elsevier (DOI): 10.1023/A:1019816830793 (DOI: 10.1023/A:1019816830793, PubMed: 15348192)
121.	Masayuki Kon, Hirakata Mayumi Luciana, Youji Miyamoto, Fumiaki Kawano and Kenzo Asaoka : Surface-layer modification of hydroxyapatite ceramic with acid and heat treatments, Dental Materials Journal, Vol.21, No.2, 170-180, 2002. (要約) The purpose of this study was to examine or characterize the surface layer of a calcium phosphate ceramic with a gradual compositional change from alpha-tricalcium phosphate (alpha-TCP) on the surface to hydroxyapatite (HAP) on the inside. The surface of a dense HAP ceramic was acid-treated for 1 hour with orthophosphoric acid (H3PO4) solutions of several concentrations (0.5, 1.0 and 5.0 mol/L) or a buffered solution (pH 4.0) consisting of phosphate solutions. After acid treatment, specimens were heat-treated at 1,250 degrees C for 1 hour. X-ray photoelectron spectroscopy revealed that the compositional gradient layer could be modified on the surface of the HAP ceramic with all acid and heat treatments, and that 5.0 mol/L H3PO4 solution and heat treatments had a maximal thickness of approximately 2 microm for the surface-modified layer. It was confirmed that the outermost layer of HAP ceramics modified with the treatments, except 5.0 mol/L H3PO4 solution, showed a compound such alpha-TCP. (キーワード) Apatite ceramic / Surface treatment / α-Tricalcium phosphate (出版サイトへのリンク) ● Publication site (DOI): 10.4012/dmj.21.170 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12238785 ● CiNii @ 国立情報学研究所 (CRID): 1390282679692695424 ● Search Scopus @ Elsevier (PMID): 12238785 ● Search Scopus @ Elsevier (DOI): 10.4012/dmj.21.170 (DOI: 10.4012/dmj.21.170, PubMed: 12238785, CiNii: 1390282679692695424)
122.	Kenichi Hamada, Masayuki Kon, Takao Hanawa, Ken'ichi Yokoyama, Youji Miyamoto and Kenzo Asaoka : Hydrothermal modification of titanium surface in calcium solutions, Biomaterials, Vol.23, No.10, 2265-2272, 2002. (要約) Hydrothermal modification of a titanium surface in calcium solutions was performed. The apatite precipitation on the modified surface in Hanks' solution, as a simulated body fluid, was evaluated and the surface microstructure changes after the modification were characterized by thin-film X-ray diffractometry (TF-XRD) and X-ray photoelectron spectroscopy (XPS). Hydrothermal modification in CaO solution enhanced the precipitation of apatite on the titanium surface. High pH, high pressure and high temperature of the CaO solution increased the thickness of the surface-modified layer and enhanced the synthesis of calcium titanate which possibly promoted the precipitation of apatite in Hanks' solution. Hydrothermal modification in CaCl2 solution, on the other hand, showed reverse effects. The modification of titanium in CaO solution with hydrothermal treatment is expected to result in excellent osteointegration and can be easily performed by using an autoclave, a clinical apparatus widely used. (キーワード) Apatites / Body Fluids / Bone and Bones / カルシウム (calcium) / Calcium Chloride / Chemical Precipitation / Electron Probe Microanalysis / Hydrogen-Ion Concentration / Microscopy, Electron, Scanning / Models, Chemical / Oxygen / 圧力 (pressure) / 温度 (temperature) / チタン (titanium) / Water / X線回折 (X-ray diffraction) (出版サイトへのリンク) ● Publication site (DOI): 10.1016/S0142-9612(01)00361-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11962668 ● Search Scopus @ Elsevier (PMID): 11962668 ● Search Scopus @ Elsevier (DOI): 10.1016/S0142-9612(01)00361-1 (DOI: 10.1016/S0142-9612(01)00361-1, PubMed: 11962668)
123.	Kunio Ishikawa, Youji Miyamoto, Tetsuya Yuasa, Atsuo Ito, Masaru Nagayama and Kazuomi Suzuki : Fabrication of Zn containing apatite cement and its initial evaluation using human osteoblastic cells, Biomaterials, Vol.23, No.2, 423-428, 2002. (要約) Recently, the effects of Zn2+ on osteogenesis stimulation have become major topics in the research fields of bone formation and organism essential elements. Based on the fundamental finding of Zn2+ with respect to osteogenesis stimulation, Ito et al. have prepared Zn doped beta-tricalcium phosphate (ZnTCP) and have reported that ZnTCP enhances the proliferation of MC3T3-E1 cells. In this investigation, we studied the effects of ZnTCP added to apatite cement (AC) with respect to its setting reaction and proliferation of human osteoblastic cells as an initial evaluation for the feasibility of AC containing ZnTCP. Compositional analysis using powder X-ray diffractometer revealed that ZnTCP shows no reactivity with the setting reaction of AC. As a result, the mechanical strength of set AC decreased increasing amounts of added ZnTCP as if ZnTCP acts as a pore in AC. The setting time of AC was not affected by addition of ZnTCP up to 10%. When AC containing ZnTCP was immersed in alpha-MEM containing 10% bovine serum, Zn2+ was released from AC. Larger amounts of Zn2+ were released from AC containing larger amounts of ZnTCP. When human osteoblastic cells were incubated on the surface of AC discs, proliferation of human osteoblastic cells was significantly increased on the surface of AC that contained 5% ZnTCP when compared with that containing no ZnTCP. In contrast, proliferation of human osteoblastic cells decreased on the surface of AC that contained 10% ZnTCP when compared with that free from ZnTCP; indicating cytotoxicity. We concluded therefore, that addition of ZnTCP to AC is useful to enhance the osteoconductivity of AC when release of Zn2+ can be carefully regulated. (キーワード) ZnTCP / Apatite cement / Osteoblasts / Proliferation (出版サイトへのリンク) ● Publication site (DOI): 10.1016/S0142-9612(01)00121-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11761162 ● CiNii @ 国立情報学研究所 (CRID): 1571417126705406208 ● Search Scopus @ Elsevier (PMID): 11761162 ● Search Scopus @ Elsevier (DOI): 10.1016/S0142-9612(01)00121-1 (DOI: 10.1016/S0142-9612(01)00121-1, PubMed: 11761162, CiNii: 1571417126705406208)
124.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikiawa, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara, Kazuomi Suzuki and Masaru Nagayama : Effects of powder phase sterilization on basic properties of apatite cement, Key Engineering Materials, Vol.218-220, 339-342, 2002. (キーワード) Apatite Cement / Hydroxyapatite / γ-Ray Irradiation (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-0036166816 (Elsevier: Scopus)
125.	Yukihiro Momota, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama and Kazuomi Suzuki : Evaluation of Feasibility of Hydroxyapatite Putty as a Local Hemostatic Agent for Bone., Journal of Biomedical Materials Research, Vol.63, No.5, 542-547, 2002. (要約) Although bone wax is known to cause an inflammatory reaction in soft tissue and a delay of bone healing, it is usually the first choice to arrest bleeding from bone. Hydroxyapatite (HAP) putty is proposed here. This study evaluated the feasibility of HAP putty with respect to whether or not it has potential value as a hemostatic agent for bone. First, the adhesive strength of HAP putty to bone was evaluated. The adhesive strength of HAP putty to wet bone was much higher when compared with that of bone wax, even though the adhesive strengths of HAP putty and bone wax to dry bone were equivalent. Next, to evaluate the hemostatic ability of HAP putty, bony defects were made in rabbits. HAP putty could arrest bleeding from bone within 3 min. However, when the hemostasis was performed with bone wax, bleeding was arrested within 8 min. Thus, HAP putty showed better hemostatic ability than bone wax. Finally, the tissue response to HAP putty in rabbit subcutaneous tissue was evaluated. Histological observation revealed a slight inflammatory response around HAP putty, whereas bone wax was surrounded by moderate inflammatory tissue. In conclusion, HAP putty has good potential value to be a hemostatic agent for bone because it has strong adhesion, good hemostatic ability, and biocompatibility. (キーワード) hemostatic agents / hydroxyapatite putty / bone wax / apatite cement, calcium phosphate cement (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jbm.10332 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12209899 ● Search Scopus @ Elsevier (PMID): 12209899 ● Search Scopus @ Elsevier (DOI): 10.1002/jbm.10332 (DOI: 10.1002/jbm.10332, PubMed: 12209899)
126.	Masaaki Takechi, Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama and Kazuomi Suzuki : Tissue responses to anti-washout apatite cement using chitosan when implanted in the rat tibia, Journal of Materials Science. Materials in Medicine, Vol.12, No.7, 597-602, 2001. (要約) The tissue response to anti-washout apatite cement using chitosan (aw-AC(chi)) was evaluated by implanting aw-AC(chi) into bone defects of rat tibiae using conventional apatite cement (c-AC) as a control material. During the experimental period up to 16 weeks, the only difference between aw-AC and c-AC was found at two weeks in the tissue response of soft tissue. At two weeks, c-AC showed a moderate inflammatory response; small particles of c-AC were scattered in the cutaneous tissue and many foreign body giant cells were collected around the scattered c-AC, whereas aw-AC showed only a slight inflammatory response and few foreign body giant cells. We found no difference between aw-AC(chi) and c-AC with respect to bone tissue response. Both AC were almost completely surrounded by mature bone at eight weeks. No promotion or reduction of osteoconductivity was observed by chitosan even though it is considered to promote bone formation. We concluded, therefore, that enhancement of bone formation cannot be expected by employing chitosan to obtain anti-washout properties, at least in the concentration used in this study, even though aw-AC(chi) is much more useful than c-AC. (出版サイトへのリンク) ● Publication site (DOI): 10.1023/A:1011285509391 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15348252 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034928206 (DOI: 10.1023/A:1011285509391, PubMed: 15348252, Elsevier: Scopus)
127.	Youji Miyamoto, Taketomo Toh, Kunio Ishikawa, Tetsuya Yuasa, Masaru Nagayama and Kazuomi Suzuki : Effect of added NaHCO₃ on the basic properties of apatite cement, Journal of Biomedical Materials Research, Vol.54, No.3, 311-319, 2001. (要約) Alternation of a composition of set apatite cement (AC) from carbonate-free apatite (CO3-free AP) to carbonate apatite (CO3-AP) may accelerate replacement of the set AC with bone because CO3-AP can be dissolved much faster than CO3-free AP in the weak acidic solution produced by osteoclasts. In this investigation, NaHCO3 was added to the AC component and the effects of added NaHCO3 on cement-setting behavior and on set mass were studied as an initial step for the fabrication of AC, which can be replaced with bone faster than current AC. When NaHCO3 was added to AC, the resultant set mass contained CO3. Although not all CO3 was incorporated in the set AC, the amount of CO3 incorporated into the set AC increased with the amount of added NaHCO3. Powder X-ray diffraction analysis and Fourier transform infrared spectrometer measurements revealed the formation of B-type CO3-AP. The setting time measured in an incubator at 37 degrees C and 100% relative humidity slowed from 30 to 45 min, indicating that NaHCO3 has an inhibitory effect on AP formation. The diametral tensile strength of the set AC decreased significantly with the addition of NaHCO3. Scanning electron microscopic observation revealed that fine crystals were formed in the set AC when NaHCO3 was added to AC. As a result, the crystallinity indices of the set AC measured using X-ray diffraction and Fourier transform infrared spectroscopy decreased with an increase in the amount of added NaHCO3. The dissolution rate of set AC in weak acid, pH 5.5, increased with the amount of added NaHCO3. We concluded that the formation of B-type CO3-AP and the resulting faster dissolution of set AC in weak acidic solution is preferable for the faster replacement of set AC with bone even though the decreased diametral tensile strength value is a shortcoming. (キーワード) apatite cement / calcium phosphate cement / carbonate apatite / hydroxyapatite / NaHCO₃ (出版サイトへのリンク) ● Publication site (DOI): 10.1002/1097-4636(20010305)54:3<311::AID-JBM10>3.0.CO;2-H (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11189035 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035809306 (DOI: 10.1002/1097-4636(20010305)54:3<311::AID-JBM10>3.0.CO;2-H, PubMed: 11189035, Elsevier: Scopus)
128.	Tetsuya Yuasa, Youji Miyamoto, Kunio Ishikiawa, Masaaki Takechi, Masaru Nagayama and Kazuomi Suzuki : In vitro resorption of three apatite cements with osteoclasts, Journal of Biomedical Materials Research, Vol.54, No.3, 344-350, 2001. (要約) To evaluate the replacement of apatite cement (AC) with bone, osteoclasts were incubated for 48 h on the surface of three AC types: conventional AC (c-AC), fast-setting AC (fs-AC), and anti-washout AC (aw-AC), using sintered apatite (AP) and cortical bone as control materials. We found osteoclasts attached to the surface of AC and osteoclastic resorption pits after 48 h of incubation for all experimental AC types. In contrast, no resorption pit was observed on the surface of sintered AP although osteoclasts were attached to the surface of sintered AP. There was no significant difference among the types of AC with respect to the resorption area, but the resorption areas were only approximately 1% of that on the surface of cortical bone. We concluded, therefore, that ACs could be replaced with bone regardless of the type but that it takes extensive time for the ACs to be completely replaced with bone. (キーワード) apatite cement / calcium phosphate cement / hydroxyapatite / osteoclasts / resorption (出版サイトへのリンク) ● Publication site (DOI): 10.1002/1097-4636(20010305)54:3<344::AID-JBM50>3.0.CO;2-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11189039 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035809842 (DOI: 10.1002/1097-4636(20010305)54:3<344::AID-JBM50>3.0.CO;2-1, PubMed: 11189039, Elsevier: Scopus)
129.	飛梅悟, 藤澤健司, 中西宏彰, 林英司, 宮本洋二, 長山勝 : 顎矯正手術により顔貌および咬合の改善が得られた第1·第2鰓弓症候群の1例, 日本口腔外科学会雑誌, Vol.46, No.2, 96-98, 2000年. (要約) We describe a case of first and second branchial arch syndrome in a patient whose profile and occlusion improved in response to orthognatic surgery.<BR>A 2-year-9-month-old boy was referred to our clinic for the treatment of open bite. Because symptoms were mild the patient was placed under observation. However, open bite and bird face became severer as he grew older. Cephalometric analysis indicated mandibular micrognathia. Before operation, we made and analyzed computer tomography-based three-dimensional models. The models were very useful for operation planning. After preoperative orthodontic treatment, sagittal splitting ramus osteotomy and horizontal sliding advancement genioplasty were performed in two stages. (キーワード) 第1・第2鰓弓症候群 / 顎矯正手術 (出版サイトへのリンク) ● Publication site (DOI): 10.5794/jjoms.46.96 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001206529016704 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.46.96 (DOI: 10.5794/jjoms.46.96, CiNii: 1390001206529016704)
130.	藤澤健司, 中西宏彰, 宮本洋二, 宮本悦子, 野田純子, 林英司, 長山勝, 島川清司, 阿部秀吉, 森瞬次 : 徳島県立ひのみね整肢医療センター歯科における心身障害児(者)の診療実態について, 四国歯学会雑誌, Vol.12, No.2, 269-275, 2000年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1573950400938250112 (CiNii: 1573950400938250112)
131.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Taketomo Toh, Tetsuya Yuasa, Masaru Nagayama and Kazuomi Suzuki : Histological and compositional evaluations of three types of calcium phosphate cements when implanted in subcutaneous tissue immediately after mixing, Journal of Biomedical Materials Research, Vol.48, No.1, 36-42, 1999. (要約) To evaluate the soft tissue response of calcium phosphate cement (CPC), consisting of an equimolar mixture of tetracalcium phosphate (TTCP) and dicalcium phosphate anhydrous (DCPA) under conditions close to those encountered in actual surgical procedures, we implanted three types of CPC [conventional CPC (c-CPC), fast-setting CPC (FSCPC), and antiwashout type FSCPC (aw-FSCPC; formerly called nondecay type FSCPC or nd-FSCPC)] subcutaneously in the abdomens of rats immediately (1 min) after mixing. At 1 week after surgery, histological examination and compositional analysis were performed using light microscopy and powder X-ray diffraction (XRD), respectively. The implanted c-CPC was crumbled completely, whereas FSCPC and aw-FSCPC retained their shape. Large vesicles containing copious inflammatory effusion were subcutaneously formed around the c-CPC. Histologically, many foreign-body giant cells were collected around the c-CPC, and moderate inflammatory cell infiltration was observed at 1 week after surgery. In contrast, the FSCPC and aw-FSCPC were covered with a thin layer of granulation tissue that included few giant cells and presented slight inflammatory cell infiltration, and no effusion was observed. The XRD analysis of the c-CPC revealed the presence of some unreacted DCPA even 1 week after implantation, whereas almost no DCPA was found in the FSCPC or aw-FSCPC. In conclusion, it was found that CPC does not always show excellent tissue response. When c-CPC is implanted subcutaneously in rats immediately after mixing, it fails to set and causes a severe inflammatory response. Therefore, the type of CPC should be chosen according to the clinical particulars. CPC should be used in a manner that assures its setting reaction. We recommend the use of FSCPC and aw-FSCPC for surgical applications, such as orthopedics, plastic and reconstructive surgery, and oral and maxillofacial surgery, where the cement might otherwise crumble due to the pressure before setting. (キーワード) Animals / Biocompatible Materials / Bone Cements / Calcium Phosphates / Foreign Bodies / Granuloma / Male / Prostheses and Implants / Rats / Rats, Wistar / 皮膚 (skin) / Skin Diseases (出版サイトへのリンク) ● Publication site (DOI): 10.1002/(sici)1097-4636(1999)48:1%3C36::aid-jbm8%3E3.0.co;2-i (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10029148 ● Search Scopus @ Elsevier (PMID): 10029148 ● Search Scopus @ Elsevier (DOI): 10.1002/(sici)1097-4636(1999)48:1%3C36::aid-jbm8%3E3.0.co;2-i (DOI: 10.1002/(sici)1097-4636(1999)48:1%3C36::aid-jbm8%3E3.0.co;2-i, PubMed: 10029148)
132.	Michiyo Kuwahara, Kikuji Yamashita, Youji Miyamoto, Fumio Nasu and Hiroshi Ishizuka : Ultrastructures of the sublingual and interpapillar surface of the human tongue, Japanese Journal of Oral Biology, Vol.41, 11-20, 1999. (キーワード) human tongue / 微細構造 (ultrastructure) / sublingual epithelium / interpapillar epithelium / microridge
133.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Masaru Nagayama, Masayuki Kon, Kenzo Asaoka and Kazuomi Suzuki : Effects of added antibiotics on the basic properties of anti-washout-type fast-setting calcium phosphate cements, Journal of Biomedical Materials Research, Vol.39, No.2, 308-316, 1998.
134.	宮本洋二, 藤澤健司, 武知正晃, 中野孝三郎, 長山勝, 鈴木温, 池田隆志, 坂東永一, 日野出大輔 : 口腔癌切除後の外科的再建部へオッセオインテグレーテッドインプラントを応用した3例, --- インプラント周囲の外科的再建組織の処理法に関する考察 ---, 日本口腔インプラント学会誌, Vol.11, No.2, 69-77, 1998年.
135.	Masayuki Kon, Youji Miyamoto, Kenzo Asaoka, Kunio Ishikiawa and Hae-Hyoung Lee : Development of calcium phosphate cement for rapid crystallization to apatite, Dental Materials Journal, Vol.17, No.4, 223-232, 1998.
136.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Taketomo Toh, Tetsuya Yuasa, Masaru Nagayama and Kazuomi Suzuki : Basic properties of calcium phosphate cement containing atelocollagen in its liquid or powder phases, Biomaterials, Vol.19, 707-715, 1998.
137.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikiawa, Taketomo Toh, Tetsuya Yuasa, Masaru Nagayama and Kazuomi Suzuki : Initial histological evaluation of anti-washout type fast-setting calcium phosphate cement following subcutaneous implantation, Biomaterials, Vol.19, 2057-2063, 1998.
138.	Takao Hanawa, Masayuki Kon, Hidemi Ukai, Kouichi Murakami, Youji Miyamoto and Kenzo Asaoka : Surface modification of titanium in calcium-ion-containing solutions, Journal of Biomedical Materials Research, Vol.34, No.3, 273-278, 1997.
139.	Kunio Ishikiawa, Youji Miyamoto, Masaaki Takechi, Taketomo Toh, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Non-decay type fast-setting calcium phosphate cement: Hydroxyapatite putty containing an increased amount of sodium alginate, Journal of Biomedical Materials Research, Vol.36, No.3, 393-399, 1997.
140.	Kunio Ishikawa, Youji Miyamoto, Masaru Nagayama and Kenzo Asaoka : Blast coating method: New method of coating titanium surface with hydroxyapatite at room temperature, Journal of Biomedical Materials Research, Vol.38, No.2, 129-134, 1997.
141.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Taketomo Toh, Yuki Yoshida, Masaru Nagayama, Masayuki Kon and Kenzo Asaoka : Tissue response to fast-setting calcium phosphate cement in bone, Journal of Biomedical Materials Research, Vol.37, No.4, 457-464, 1997.
142.	Youji Miyamoto, Kenji Fujisawa, Masaru Nagayama, Norio Haneji and Yoshio Hayashi : Carcinoma in Pleomorphic Adenoma of the Tongue ; Report of a case, Oral Medicine & Pathology, Vol.1, No.2, 111-114, 1996. (要約) A carcinoma in pleomorphic adenoma occurring in the tongue of a 47-year-old Japanese woman is reported. The present report is the first to describe a carcinoma in pleomorphic adenoma derived from the posterior lingual glands. (キーワード) carcinoma in pleomorphic adenoma / lingual gland / malignant mixed tumor / pleomorphic adenoma / tongue (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1570009752234590720 (CiNii: 1570009752234590720)
143.	Youji Miyamoto, Masaru Nagayama and Yoshio Hayashi : Verruciform xanthoma occurring within oral lichen planus, Journal of Oral Pathology & Medicine, Vol.25, No.4, 188-191, 1996.
144.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Non-decay type fast-setting calcium phosphate cement: setting behaviour in calf serum and its tissue response, Biomaterials, Vol.17, 1429-1435, 1996.
145.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Soft tissue response of calcium phosphate cements, Bioceramics, Vol.9, 263-266, 1996.
146.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikiawa, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Basic properties of hydroxyapatite putty made with fast-setting calcium phosphate cement and sodium alginate, Bioceramic, Vol.9, 235-238, 1996.
147.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Masaru Nagayama, Masayuki Kon and Kenzo Asaoka : Non-decay type fast-setting calcium phosphate cement using chitosan, Journal of Materials Science Materials in Medicine, Vol.7, No.6, 317-322, 1996.
148.	Kunio Ishikawa, Youji Miyamoto, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Non-decay type fast-setting calcium phosphate cement, --- : Composite with sodium alginate ---, Biomaterials, Vol.16, No.7, 527-432, 1995.
149.	Masayuki Kon, Kunio Ishikawa, Youji Miyamoto and Kenzo Asaoka : Development of calcium phosphate based functional gradient bioceramics, Biomaterials, Vol.16, No.9, 709-714, 1995.
150.	Youji Miyamoto, Kunio Ishikawa, Hirokazu Fukao, Masahiro Sawada, Masaru Nagayama, Masayuki Kon and Kenzo Asaoka : In vivo setting behavior of fast-setting calcium phosphate cement, Biomaterials, Vol.16, No.11, 855-860, 1995. (要約) The in vivo setting behaviour of fast-setting calcium phosphate cement (FSCPC) between femoral muscles of the rat was investigated to evaluate the possible value of FSCPC for medical and dental application. Conventional CPC (c-CPC) and FSCPC were implanted between femoral muscles, and various aspects of the setting behaviour such as setting time, mechanical strength and conversion ratio of cement into hydroxyapatite (HAP: Ca10(PO4)6(OH)2) were measured by the Vicat needle method, diametral tensile strength (DTS) measurement, and quantitative powder X-ray diffraction (XRD) analysis, respectively. The setting time of FSCPC in vivo was 5-7 min, in contrast to 48 min for c-CPC. As a result of its fast setting, set specimens of FSCPC showed higher mechanical strength from the initial stage than c-CPC. Higher DTS values were observed in FSCPC than c-CPC implanted after 24 h. Powder XRD analysis revealed faster conversion of FSCPC than c-CPC into HAP, which was responsible both for the faster setting and higher mechanical strength from the initial stage. We concluded, therefore, that FSCPC may be used for a wide range of clinical applications, i.e. fields where fast setting is required such as orthopaedic, plastic and reconstructive, and oral and maxillofacial surgery. (キーワード) Animals / Biocompatible Materials / Bone Cements / Calcium Phosphates / Durapatite / Femur / Male / Muscle, Skeletal / Prostheses and Implants / Rats / Rats, Wistar / Tensile Strength / X線回折 (X-ray diffraction) (出版サイトへのリンク) ● Publication site (DOI): 10.1016/0142-9612(95)94147-D (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8527601 ● Search Scopus @ Elsevier (PMID): 8527601 ● Search Scopus @ Elsevier (DOI): 10.1016/0142-9612(95)94147-D (DOI: 10.1016/0142-9612(95)94147-D, PubMed: 8527601)
151.	里村一人, 力丸浩一, 林英司, 野沢孝行, 宮本洋二, 長山勝 : 過去10年間のガマ腫39症例の臨床的検討, 日本口腔科学会雑誌, Vol.44, No.2, 261-264, 1995年.
152.	里村一人, 板東泰博, 林英司, 宮本洋二, 長山勝 : 維持透析患者に生じた舌癌の1治験例, 日本口腔外科学会雑誌, Vol.40, No.9, 1009-1011, 1994年.
153.	宮本洋二, 滝下幸夫, 林英司, 長山勝, 東富雄, 林良夫, 高橋敬治, 宇山正 : 顎下腺と肺の重複癌の1例, 日本口腔腫瘍学会誌, Vol.4, No.2, 264-269, 1992年.
154.	川田真也, 林英司, 宮本洋二, 長山勝, 出口博代, 東富雄, 林良夫 : セメント質形成線維腫の4例, 日本口腔外科学会雑誌, Vol.38, No.3, 479-485, 1992年.
155.	林英司, 堀昭夫, 宮本洋二, 長山勝, 出口博代, 林良夫 : 剖検により原発性肺癌の顎下部転移と考えられた1例, 日本口腔外科学会雑誌, Vol.38, No.4, 679-680, 1992年.
156.	Youji Miyamoto, Masaru Nagayama and Yoshio Hayashi : A Cleft Child With Lobulated Tongue and Lingual Hamartoma: Report of a Case, Journal of Oral and Maxillofacial Surgery, Vol.49, No.6, 644-646, 1991. (キーワード) Cleft Palate / Female / Hamartoma / Humans / Infant / Tongue / Tongue Neoplasms (出版サイトへのリンク) ● Publication site (DOI): 10.1016/0278-2391(91)90348-P (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 2037922 ● Search Scopus @ Elsevier (PMID): 2037922 ● Search Scopus @ Elsevier (DOI): 10.1016/0278-2391(91)90348-P (DOI: 10.1016/0278-2391(91)90348-P, PubMed: 2037922)
157.	宮本洋二, 松本文博, 滝下幸夫, 長山勝, 出口博代, 林良夫 : 舌に孤立性に生じた神経線維腫の1例, 日本口腔外科学会雑誌, Vol.37, No.6, 1187-1188, 1991年.
158.	Fumihiro Matsumoto, Youji Miyamoto and Masaru Nagayama : Light-and Electron-Microscopic Observations on the Mandibular Condylar Cartilages in Growing Rats on a Low-Calcium Diet, Acta Anatomica, Vol.142, No.1, 41-48, 1991. (要約) In order to obtain more insight into the physiologic mechanism of endochondral ossification, histological changes occurring in the mandibular condylar cartilage of growing rats fed on a low-calcium diet were investigated by light and electron microscopy. Twenty-three-day-old rats were fed on a normal diet or a low-calcium diet for 8 weeks. For the histological observations the mandibular condyles were dissected from each animal at 1, 2, 4, 5 and 8 weeks after the initiation of the experiment. Histological changes occurring in the mandibular condylar cartilages of the rats fed on a low-calcium diet were as follows: (1) narrow proliferative and mature cell zones and a wide hypertrophic cell zone, (2) inhibition of development of cell organelles in the mature chondrocytes, (3) decrease in dead cells in the proliferative zone, (4) decrease in glycogen accumulation in the chondrocytes and (5) inhibition of calcification in the extracellular matrix of the hypertrophic cell zone. Additionally at the end of the experimental period, the following findings were observed: (1) appearance of small light cells in the mature cell zone and the hypertrophic cell zone and (2) decrease in proteoglycan granules and appearance of large collagen fibrils in the pericellular region of the hypertrophic cell zone. (キーワード) Animals / Bone Development / Calcium, Dietary / Cartilage, Articular / Collagen / Diet / Male / Mandible / Organelles / Rats / Rats, Inbred Strains (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 1781238 ● Search Scopus @ Elsevier (PMID): 1781238 (PubMed: 1781238)
159.	宮本洋二, 安田勝裕, 林英司, 藤澤健司, 川田真也, 原友則, 長山勝 : 当科における5年間の小児入院患者の臨床統計的観察, 小児口腔外科, Vol.1, No.2, 111-117, 1991年.
160.	藤澤健司, 中西宏彰, 里村一人, 安田勝裕, 宮本洋二, 長山勝, 出口博代, 林良夫 : 石灰化歯原性嚢胞の3例, 日本口腔科学会雑誌, Vol.40, No.4, 900-911, 1991年.
161.	宮本洋二, 長山勝, 高木知道 : マウス(BALB/c)二次口蓋突起癒合に関する研究, --- 変性細胞の分布と上皮細胞の移動について ---, 解剖学雑誌, Vol.62, No.1, 5-18, 1987年.
162.	Tomomichi Takagi, Kazuyoshi Nishikawa, Noboru Kanematsu, Youji Miyamoto and Hideo Tsutsui : On the double relief pattern of incisors and the central tubercles of premolars, Japanese Journal of Oral Biology, Vol.28, No.6, 752-756, 1986.
163.	喜多孝志, 佐藤圭, 河田耕治, 吉成美予, 兼松登, 岩目益芳, 福田望, 安田勝裕, 宮本洋二, 佐藤純, 椋本稔敏, 吉田幸子 : 口腔悪性腫瘍に対するPepleomycin使用についての臨床的検討, 日本口腔外科学会雑誌, Vol.31, No.8, 1911-1916, 1985年.

学術論文(紀要・その他):

1.	宮本洋二, 福田直志, 工藤景子 : 口腔領域における骨補填材としての炭酸アパタイトの現状と今後の展開, 日本口腔インプラント学会誌, Vol.35, No.4, 268-275, 2022年. (キーワード) 骨造成術 / 骨補塡材 / 骨再生医療 / 炭酸アパタイト / ハイドロキシアパタイト (hydroxyapatite) (徳島大学機関リポジトリ) ● Metadata: 117953 (出版サイトへのリンク) ● Publication site (DOI): 10.11237/jsoi.35.268 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390857899425066624 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.35.268 (徳島大学機関リポジトリ: 117953, DOI: 10.11237/jsoi.35.268, CiNii: 1390857899425066624)
2.	K Ishikawa, Youji Miyamoto, A Tsuchiya, K Hayashi, K Tsuru and Go Ohe : Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and -Tricalcium Phosphate Bone Substitutes., Materials, Vol.11, No.10, 2018. (要約) Three commercially available artificial bone substitutes with different compositions, hydroxyapatite (HAp; Neobone), carbonate apatite (CO3Ap; Cytrans), and β-tricalcium phosphate (β-TCP; Cerasorb), were compared with respect to their physical properties and tissue response to bone, using hybrid dogs. Both Neobone (HAp) and Cerasorb (β-TCP) were porous, whereas Cytrans (CO3Ap) was dense. Crystallite size and specific surface area (SSA) of Neobone (HAp), Cytrans (CO3Ap), and Cerasorb (β-TCP) were 75.4 ± 0.9 nm, 30.8 ± 0.8 nm, and 78.5 ± 7.5 nm, and 0.06 m²/g, 18.2 m²/g, and 1.0 m²/g, respectively. These values are consistent with the fact that both Neobone (HAp) and Cerasorb (β-TCP) are sintered ceramics, whereas Cytrans (CO3Ap) is fabricated in aqueous solution. Dissolution in pH 5.3 solution mimicking Howship's lacunae was fastest in CO3Ap (Cytrans), whereas dissolution in pH 7.3 physiological solution was fastest in β-TCP (Cerasorb). These results indicated that CO3Ap is stable under physiological conditions and is resorbed at Howship's lacunae. Histological evaluation using hybrid dog mandible bone defect model revealed that new bone was formed from existing bone to the center of the bone defect when reconstructed with CO3Ap (Cytrans) at week 4. The amount of bone increased at week 12, and resorption of the CO3Ap (Cytrans) was confirmed. β-TCP (Cerasorb) showed limited bone formation at week 4. However, a larger amount of bone was observed at week 12. Among these three bone substitutes, CO3Ap (Cytrans) demonstrated the highest level of new bone formation. These results indicate the possibility that bone substitutes with compositions similar to that of bone may have properties similar to those of bone. (徳島大学機関リポジトリ) ● Metadata: 115588 (出版サイトへのリンク) ● Publication site (DOI): 10.3390/ma11101993 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30332751 ● Summary page in Scopus @ Elsevier: 2-s2.0-85054990038 (徳島大学機関リポジトリ: 115588, DOI: 10.3390/ma11101993, PubMed: 30332751, Elsevier: Scopus)
3.	北村清一郎, 二宮雅美, 宮本洋二 : カラーアトラス:皮膚・粘膜の下，透けて見えますか, --- 歯科医師・口腔外科医に必要な解剖学の知識 ---, 歯界展望, Vol.10, No.6, 2007年.
4.	北村清一郎, 篠原千尋, 宮本洋二 : 歯科局所麻酔時に必要な解剖学の知識, --- より効果的な麻酔を目指して ---, 「見える! わかる! 臨床に役立つ解剖写真集 5」，歯界展望, Vol.101, No.5, 964-968, 2006年.
5.	宮本洋二, 藤澤健司, 山内英嗣 : 口腔外科の視点からみた即時荷重インプラント, 補綴臨床別冊即時インプラント, 36-42, 2005年.
6.	宮本洋二 : 歯科インプラントの安定性評価のための共鳴振動周波数分析装置「オステル」について, 日本歯科評論, Vol.63, No.11, 119-124, 2003年.
7.	Masayuki Kon, Mayumi Luciana Hirakata, Youji Miyamoto and Kenzo Asaoka : Evaluation of bioceramics containing a-tricalcium phosphate, Archives of BioCeramics Research, Vol.3, 118-123, 2003.
8.	Mayumi Luciana Hirakata, Masayuki Kon, Tetsuya Yuasa, Youji Miyamoto and Kenzo Asaoka : Influences of crystal phases on bioactivity of calcium phosphate cements, Key Engineering Materials, Vol.218-220, 343-346, 2001.
9.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Soft tissue responses of calcium phosphate cements, Bioceramics, Vol.9, 263-266, 1996.
10.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Basic properties of hydroxyapatite putty made with fast-setting calcium phosphate cement and sodium alginate, Bioceramics, Vol.9, 235-238, 1996.
11.	Kunio Ishikawa, Youji Miyamoto, Masaaki Takechi, Taketomo Toh, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Approaches for bone-replacing calcium phosphate cement, --- Effect of NaHCO3 addition on the properties of calcium phosphate cement ---, Bioceramics, Vol.9, 255-258, 1996.

総説・解説:

1.	湯本浩通, 山村佳子, 石丸直澄, 宮本洋二 : Dd診断力てすと歯肉と頬粘膜の白色病変, デンタルダイアモンド, Vol.48, No.5, 25-26, 2023年4月.
2.	宮本洋二, 福田直志, 秋田和也, 工藤景子, 栗尾奈愛 : 骨補填材としての炭酸アパタイトの現状と今後の展開, 日本顎顔面インプラント学会誌, Vol.20, No.2, 88-95, 2021年8月. (要約) A main inorganic component of human bone is not hydroxyapatite but carbonate apatite (CQ3Ap). Hydroxyapatite is not resorbed in the body but C03Ap can be resorbed and replaced with bone. We have succeeded in fabricating low crystalline CQ3Ap without sintering by dissolution-precipitation reaction using calcium hydroxide as a precursor. C03Ap showed excellent biocompatibility and faster bone formation compared to other bone substitutes (anorganic bovine bone and hydroxyapatite) in rabbit femur and dog mandible. Clinical study on effectiveness and safety of C03Ap granules in sinus floor augmentation was successfully concluded in 2016. CQ3Ap granules were approved by Japanese government in 2017, and marketed in 2018 as Cytrans® Granules. This comprehensive review explains the clinical cases of sinus lift and alveolar ridge augmentation of Cytrans® and its recommended clinical usage. Furthermore, we have succeeded in developing porous C03Ap and showed it was useful for reconstruction of mandibular bone defect in rabbit model and also aim to use it as a scaffold for bone regenerative medicine. (キーワード) apatite / bone substitute / bone regenerative medicine / carbonate apatite / アパタイト / 骨補填材 / 骨再生医療 / 炭酸アパタイト (徳島大学機関リポジトリ) ● Metadata: 116329 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1010576118550922112 (徳島大学機関リポジトリ: 116329, CiNii: 1010576118550922112)
3.	宮本洋二, 栗尾奈愛, 工藤景子, 髙丸菜都美 : インプラント治療における口腔外科の基本手技とリスクマネージメント, 日本口腔インプラント学会誌, Vol.34, No.1, 26-32, 2021年3月. (キーワード) 歯科インプラント / 医療事故 / 手術手技 / dental implant / medical accident / operative procedure (出版サイトへのリンク) ● Publication site (DOI): 10.11237/jsoi.34.26 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390287827491626624 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.34.26 (DOI: 10.11237/jsoi.34.26, CiNii: 1390287827491626624)
4.	宮本洋二, 山中克之, 福田直志, 秋田和也 : 再生療法の最前線 Ⅳ．サイトランスグラニュールを活用するためのポイント(Q&A), 日本歯科評論, Vol.79, No.9, 58-63, 2019年8月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1521417755960165504 (CiNii: 1521417755960165504)
5.	宮本洋二, 山中克之, 福田直志, 秋田和也 : 再生療法の最前線 Ⅲ．サイトランスグラニュールを効果的に使用するために知っておきたい知識(概説), 日本歯科評論, Vol.79, No.9, 54-57, 2019年8月. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1522262179862336768 (CiNii: 1522262179862336768)
6.	宮本洋二, 工藤景子, 大江剛, 髙丸菜都美 : 再生療法の最前線 Ⅴ．サイトランスグラニュールを用いた上顎洞底挙上術の長期経過, 日本歯科評論, Vol.79, No.9, 68-73, 2019年8月.
7.	高石和美, 藤原茂樹, 江口覚, 大塚良, 赤澤友基, 北村尚正, 上田(山口) 公子, 中川弘, 可児耕一, 青田桂子, 桃田幸弘, 山村佳子, 工藤景子, 大江剛, 玉谷哲也, 宮本洋二, 東雅之, 岩本勉, 北畑洋 : 当院における全身麻酔下歯科治療について -障害をもつ方へ安全な歯科治療の提供-, Journal of Oral Health and Biosciences, Vol.31, No.1, 62-67, 2018年7月. (要約) We report about general anesthesia for disabled patients with special needs or young children during dental treatment in Tokushima University Hospital. We have administered ambulatory anesthesia or general anesthesia with short-term hospitalization for the patients. In this report, we showed anesthesia as a behavior management technique and the system for the patients who schedule ambulatory anesthesia in our hospital. We indicated the present situation of dental treatment under general anesthesia and supposed the prospects of dental care for the patients with special needs. (キーワード) 全身麻酔 / 障害者 / 日帰り全身麻酔 / 歯科治療 (徳島大学機関リポジトリ) ● Metadata: 111940 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.31.1_62 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390845712973457920 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_62 (徳島大学機関リポジトリ: 111940, DOI: 10.20738/johb.31.1_62, CiNii: 1390845712973457920)
8.	宮本洋二 : 新規骨補填材としての炭酸アパタイトの開発と薬事承認, 歯界展望, Vol.131, No.5, 877-883, 2018年5月.
9.	宮本洋二, 玉谷哲也, 大江剛, 髙丸菜都美, 工藤景子, 山村佳子, 藤澤健司, 永井宏和 : 新しい外科の概念と手術手技の進歩, Journal of Oral Health and Biosciences, Vol.29, No.1, 7-12, 2016年6月. (要約) Although the recent progress in surgery is remarkable, many dentists do not recognize it enough. From three viewpoints, we introduce and exposit new concept of treatment for wound, device (instrument) for arrest of hemorrhage, and operation procedure by surgical knife. It is always important for dentists to continue taking in new knowledge and techniques. (キーワード) 創傷処置 / 消毒 / 手術時手洗い / エナジーデバイス (徳島大学機関リポジトリ) ● Metadata: 109747 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050583647831063808 (徳島大学機関リポジトリ: 109747, CiNii: 1050583647831063808)
10.	永田俊彦, 宮本洋二 : ビスフォスフォネート関連顎骨壊死をめぐる話題 (特集すべての医師のための骨粗鬆症診療ガイド2010), 綜合臨牀, Vol.59, No.4, 540-543, 2010年4月. (キーワード) 顎骨壊死 / ビスフォスフォネート / 副作用 / 骨粗鬆症 / 悪性腫瘍 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520854805754960640 (CiNii: 1520854805754960640)
11.	藤澤健司, 永井宏和, 宮本洋二 : 自家骨を用いたサイナスリフトの術式と予後について, 四国歯学会雑誌, Vol.22, No.2, 191-197, 2010年. (徳島大学機関リポジトリ) ● Metadata: 109798 (徳島大学機関リポジトリ: 109798)
12.	北村清一郎, 高橋章, 宮本洋二 : 口腔外科医に必要な局所解剖学の知識11-頸部前面の深層—口腔の炎症が全身に拡がる経路を理解するために, 歯界展望, Vol.111, No.5, 904-911, 2008年5月.
13.	北村清一郎, 高橋章, 宮本洋二 : 歯科医師・口腔外科医に必要な局所解剖学の知識11, --- 頸部前面の深層—口腔の炎症が全身に拡がる経路を理解するために ---, 歯界展望, Vol.111, No.5, 904-911, 2008年5月.
14.	北村清一郎, 高橋章, 宮本洋二 : 歯科医師・口腔外科医に必要な局所解剖学の知識10—前頸部の皮下組織と顎下部—顎下部の腫れを理解するために, 歯界展望, Vol.111, No.4, 690-697, 2008年4月.
15.	北村清一郎, 高橋章, 宮本洋二 : 口腔外科医に必要な局所解剖学の知識9—翼突下顎隙と翼突前隙—口腔の「奥座敷(炎症波及路)」としての重要性を考, 歯界展望, Vol.111, No.3, 494-501, 2008年3月.
16.	北村清一郎, 高橋章, 宮本洋二 : 歯科医師・口腔外科医に必要な局所解剖学の知識8—咬筋・耳下腺部と側頭部，および下顎後窩—耳下腺手術および下顎骨折時の対応のために, 歯界展望, Vol.111, No.2, 280-287, 2008年2月.
17.	北村清一郎, 山下菊治, 宮本洋二 : 口腔外科医に必要な局所解剖学の知識5—舌と下顎骨—口腔機能の立役者である舌の機能を理解する, 歯界展望, Vol.110, No.5, 868-875, 2007年11月.
18.	北村清一郎, 益井孝文, 宮本洋二 : 口腔外科医に必要な局所解剖学の知識4—舌下部—この恐い部位を克服するために, 歯界展望, Vol.110, No.4, 652-659, 2007年10月.
19.	宮本洋二, 北村清一郎, 益井孝文 : カラーアトラス:皮膚・粘膜の下，透けて見えますか, --- 歯科医師・口腔外科医に必要な解剖学の知識 ---, 歯界展望, Vol.110, No.4, 652-659, 2007年10月.
20.	北村清一郎, 二宮雅美, 宮本洋二 : 口腔外科医に必要な局所解剖学の知識3口腔前庭—外科処置に失敗しないために, 歯界展望, Vol.110, No.3, 458-465, 2007年9月.
21.	北村清一郎, 二宮雅美, 宮本洋二 : 歯科医師・口腔外科医に必要な局所解剖学の知識3口腔前庭—外科処置に失敗しないために, 歯界展望, Vol.110, No.3, 458-465, 2007年9月.
22.	北村清一郎, 角田佳折, 宮本洋二 : 歯科医師・口腔外科医に必要な局所解剖学の知識1顔の皮下組織—``顔の美しさを守るプロ''として知っておくべきこと, 歯界展望, Vol.110, No.1, 62-69, 2007年7月.
23.	Daisuke Hinode, Shin-ichi Tanabe, Masaaki Yokoyama, Kenji Fujisawa, Eiji Yamauchi and Youji Miyamoto : Influence of smoking on osseointegrated implant failure: a meta-analysis, Clinical Oral Implants Research, Vol.17, No.4, 473-478, Aug. 2006. (要約) The aim of this study was to examine the influence of smoking on osseointegrated implant failure by performing a meta-analysis. A computerized literature search using PubMed database (in English) and Japana Centra Revuo Medicina (in Japanese) was carried out to identify all relevant studies. Among 175 studies identified and chosen for detailed review, 19 were appropriate for inclusion in our meta-analysis. When smokers were compared with non-smokers, odds ratio (OR) for osseointegrated implant failure was significantly elevated (OR 2.17, 95% confidence intervals (CI), 1.67-2.83). Seven studies were appropriate to examine the influence of intra-oral location (maxillary arch vs. mandibular arch) of implant failure on smoking. The OR for implant failure occurring in the maxillary arch was significantly elevated (OR 2.06, 95% CI, 1.61-2.65), whereas the OR in the mandibular arch did not demonstrate a significant increased risk associated with smoking (OR 1.32, 95% CI, 0.72-2.4). Our meta-analysis revealed a significant relationship between smoking and the risk of osseointegrated implant failure, more particularly those implants located in the maxillary arch. (キーワード) Dental Arch / Dental Implantation, Endosseous / Dental Implants / Dental Restoration Failure / Epidemiologic Methods / Humans / Mandible / Maxilla / Smoking (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1600-0501.2005.01244.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16907781 ● Search Scopus @ Elsevier (PMID): 16907781 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1600-0501.2005.01244.x (DOI: 10.1111/j.1600-0501.2005.01244.x, PubMed: 16907781)
24.	北村清一郎, 篠原千尋, 宮本洋二 : 見える!わかる!臨床に役立つ解剖写真集5, --- 歯科局所麻酔時に必要な解剖学の知識 -より効果的な麻酔を目指して- ---, 歯界展望, Vol.107, No.5, 964-968, 2006年5月.
25.	宮本洋二 : 歯科インプラント失敗のリスクファクターと治療成績向上のための対策, 四国歯学会雑誌, Vol.18, No.2, 211-220, 2006年1月. (徳島大学機関リポジトリ) ● Metadata: 254 (徳島大学機関リポジトリ: 254)
26.	北村清一郎, 石橋淳, 宮本洋二 : 臼後三角の局所解剖学, --- 下顎智歯抜歯時の偶発症を防ぐには ---, 「見える! わかる! 臨床に役立つ解剖写真集 6」，歯界展望, Vol.101, No.6, 1194-1199, 2006年.
27.	面川進, 宮本洋二 : 歯科口腔外科領域における自己多血小板血漿ゲルの有用性, 日本アフェレシス学会誌, Vol.25, No.3, 197-203, 2006年.
28.	北村清一郎, 石橋淳, 宮本洋二 : 見える!わかる!臨床に役立つ解剖写真集—6, --- 臼後三角の局所解剖学—下顎智歯抜歯時の偶発症を防ぐには ---, 歯界展望, Vol.107, No.6, 1194-1199, 2006年.
29.	宮本洋二 : 歯科インプラントの現況と課題:歯がなくなってお困りではないですか?, 秋田医学, Vol.32, No.2, 105-112, 2005年9月.
30.	田部慎一, 日野出大輔, 横山正明, 宮本洋二, 中村亮 : 骨結合型インプラント治療の予後に対する喫煙の影響文献的考察から, 口腔衛生学会雑誌, Vol.51, No.3, 196-202, 2001年7月.
31.	宮本洋二, 長山勝 : 顎・顔面の再建手術について, 四国歯学会雑誌, Vol.9, No.2, 99-113, 1997年1月.

国際会議:

1.	Tetsuya Yuasa, Youji Miyamoto, Yukihiro Momota, Nobuyuki Kamata, Masaru Nagayama, Masayuki Kon and Kunio Ishikawa : Effects of sintered apatite, apatite cement on differentiation of human immortalized dental papilla cells, 3rd Asian BioCeramic Symposium(ABC 2003)in conjunction with Hard-Tissue Nano-Biomaterials Symposium 2003, Fukuoka, (要約) 1
2.	Seiko Tatehara, Youji Miyamoto, Tetsuya Yuasa, Masaaki Takechi, Masaru Nagayama, Masayuki Kon and Kunio Ishikawa : Mechanism for promotion of the differentiation of human cultured osteoblasts by calciumphosphate ceramics, 3rd Asian BioCeramic Symposium(ABC 2003)in conjunction with Hard-Tissue Nano-Biomaterials Symposium 2003, Fukuoka, (要約) 1
3.	Youji Miyamoto, Seiko Tatehara, Tetsuya Yuasa, Hiroaki Nakanishi, Kenji Fujisawa and Masaru Nagayama : Measurement of the Zygomatic bone and pilot hole technique for safer installation of zygomatic implant, 16th International Conference on Oral and Maxillofacial Surgery(ICOMS), Athens, (要約) 1
4.	Seiko Tatehara, Youji Miyamoto, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa and Masaru Nagayama : Effect of locally applied basic firoblast growth factor on distraction osteogenesis in ovadectomized rats, 16th Intemational Conference on Oral and Maxillofacial Surgery(ICOMS), Athens, (要約) 1
5.	Shiho Minamiguchi, Masaaki Takechi, Tetsuya Yuasa, Yukihiro Momota, Seiko Tatehara, Hideyuki Takano, Youji Miyamoto, Kazuhito Satomura and Masaru Nagayama : A basic research on hydroxyapatite-poly(D L-lactide-co glycolic acid)composite scaffolds for bone tissue engineering, The 5th Asian Bio Ceramics Simposium, (要約) 1
6.	宮本洋二 : 新規骨補填材としての炭酸アパタイトの現状と骨再生医療への展開, 第21回再生医療学会総会，シンポジウム「新しく開発された生体材料による骨再生研究の最前線」, 2022年3月.
7.	Naoyuki Fukuda, Takamitsu Mano, Kazuya Akita, 鎌田久美子, Takayuki Nakagawa and Youji Miyamoto : Effects Of Acidic Calcium Phosphate Concentration On Setting Reaction To ß-Tricalcium Phosphate Granular Cement, 24th Congress of the European Association for Cranio Maxillo Facial Surgery, Sep. 2018.
8.	Takamitsu Mano, Naoyuki Fukuda, Kazuya Akita, Kumiko Kamada, Naito Kurio and Youji Miyamoto : Comparative Study On Tissue Response To Low Crystalline Carbonate Apatite, NEOBONE® And Bio-Oss® In A Dog Model, 24th Congress of the European Association for Cranio Maxillo Facial Surgery, Sep. 2018.
9.	Yoshiko Yamamura, Tetsuya Tamatani, Keiko Kudoh, 秋田和也, 鎌田久美子 and Youji Miyamoto : The Changes Of Genes And MicroRNA Expression Induced By Submandibular Gland Atrophy, 24th Congress of the European Association for Cranio Maxillo Facial Surgery, Sep. 2018.
10.	Masako Fujioka-Kobayashi, Tsuru Kanji, Ishikawa Kunio and Youji Miyamoto : Fabrication and Evaluation of Carbonate Apatite-coated Calcium Carbonate Bone Substitutes, The 4th National Osteology Symposium in Switzerland, Jan. 2018.
11.	Tetsuya Tamatani, Natsumi Takamaru, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : Expression of SOX2 and Oct4 in human oral squamous cell carcinoma and its relationship with clinical factors, AACR Annual Meeting 2017, Apr. 2017.
12.	Tetsuya Tamatani, Natsumi Takamaru, Kenji Fujisawa, Hirokazu Nagai and Youji Miyamoto : Expression of ALDH1, Bmi-1 and CD24 in human oral squamous cell carcinoma and its relationship with clinical factors, AACR Annual Meeting 2016, Apr. 2016.
13.	Masako Fujioka-Kobayashi, Hirokazu Nagai, Kanae Hara, Kenji Fujisawa, Daisuke Uchida, Tetsuya Tamatani and Youji Miyamoto : Nobel Bone Regeneration System Using Carbonate Apatite-coated Carbonate Calcium in Vivo, American association of Oral Maxillofacial Surgeons(aaoms) 96th Annual Meeting, scientific Sessions & Exhibition, Sep. 2014.
14.	Hirokazu Nagai, Kanae Hara, Masako Fujioka-Kobayashi, Go Ohe, Tetsuya Tamatani, Kenji Fujisawa and Youji Miyamoto : Application of Low Crystalline Carbonate Apatite Combined With BMP-2 to Bone Reconstruction, American association of Oral Maxillofacial Surgeons(aaoms) 96th Annual Meeting, scientific Sessions & Exhibition, Sep. 2014.
15.	Natsumi Takamaru, Tetsuya Tamatani, Daisuke Uchida, Nobuyuki Kuribayashi, Go Ohe, Hirokazu Nagai and Youji Miyamoto : Clinicopathological Evaluation of Late cervical Lymph Node Metastatsis fo Oral Squamous Cell Carcinoma, American association of Oral Maxillofacial Surgeons(aaoms) 96th Annual Meeting, scientific Sessions & Exhibition, Sep. 2014.
16.	Tetsuya Tamatani, Natsumi Takamaru, Makoto Kinouchi, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai and Youji Miyamoto : Express of ABCG2, ALDH1A1, CD44, and CD44 variant 9 in human oral squamous cell carcinoma and its relationship with clinical factors., AACR Annual Meeting 2014, Apr. 2014.
17.	Nobuyuki Kuribayashi, Daisuke Uchida, Makoto Kinouchi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : The role of metabotropic glutamate receptor 5 on the lymph node metastases in oral cancer., AACR Annual Meeting 2014, Apr. 2014.
18.	Makoto Kinouchi, Daisuke Uchida, Nobuyuki Kuribayashi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Isolation of a novel metastasis-related microRNA, miR-518c-5p, induced by the stromal cell-derived factor(SDF)-1/CXCR4 system in oral cancer, AACR Annual Meeting 2014, Apr. 2014.
19.	Makoto Kinouchi, Daisuke Uchida, Nobuyuki Kuribayashi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Functional analysis of metastasis-related microRNA induced by the stromal-cell derived factor (SDF)-1/CXCR4 system in oral cancer, American Associattion for Cancer Research Annual Meeting 2013, Apr. 2013.
20.	Nobuyuki Kuribayashi, Daisuke Uchida, Yasusei Kudo, Makoto Kinouchi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Expression and function of CXCR4 in human salivary gland cancers, American Associattion for Cancer Research Annual Meeting 2013, Apr. 2013.
21.	Tetsuya Tamatani, Natsumi Takamaru, Makoto Kinouchi, Nobuyuki Kuribayashi, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : The expression of nuclear factor-B in human oral squamous cell carcinoma and its relationship with clinical factors, AACR Annual Meeting 2013, Apr. 2013.
22.	Daisuke Uchida, Nobuyuki Kuribayashi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Induction of VEGF-C expression via mGluR5 in the lymph node metastases of oral cancer by the SDF-1/CXCR4 system, American Associattion for Cancer Research Annual Meeting 2012, Apr. 2012.
23.	Tetsuya Tamatani, Natsumi Takamaru, Daisuke Uchida, Hirokazu Nagai, Kenji Fujisawa and Youji Miyamoto : The expression of X-linked inhibitor of apoptosis in human oral squamous cell carcinoma and its relationship with clinical factors, American Associattion for Cancer Research Annual Meeting 2012, Apr. 2012.
24.	Daisuke Uchida, Nobuyuki Kuribayashi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Inhibition of SDF-1/CXCR4 dependent-metastases by the treatment with metabotropic glutamate receptor 5 (mGluR5) antagonists in oral cancer, AACR 102nd Annual Meeting 2011 Proceedings, Vol.52, 583, Apr. 2011.
25.	Daisuke Uchida, Nobuyuki Kuribayashi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Isolation and analysis of metastasis-related genes in an oral cancer cells with autocrine stromal cell-derived factor -1/CXCR4 system, Proceeding of American Association for Cancer Research, Apr. 2010.
26.	Siho Minamiguchi, Masaaki Takechi, Yukihiro Momota, Youji Miyamoto, Kazuhito Satomura and Masaru Nagayama : A research on the rat subcutaneous tissue of hydroxyapatite-polyD, L-Iactic-co-glycolic acid (PLGA)composite scaffolds for allopatry bone generation., 第1回国際シンポジウム・FDワークショップ「21 世紀の口腔科学が目指すべき方向性」, Awaji, 2007. (要約) 1
27.	Yukihiro Momota, Youji Miyamoto, K Ishikawa, Masaaki Takechi, H Takano and Masaru Nagayama : Enhancing Effects on Aggregation of Platelets by Hydroxyapatite Putty as a Topical Hemostatic Agent for Bone, The First International Conference on Mechanics of Biomaterials and Tissues, hawaii, Dec. 2005.
28.	Kenji Fujisawa, Youji Miyamoto, Eiji Yamauchi, Masaaki Takechi, Yukihiro Momota, Tetsuya Yuasa, Seiko Tatehara and Masaru Nagayama : Immediate functional loading of Branemark system implants: One year clinical follow-up study, International Journal of Oral & Maxillofacial Surgery, Vol.34, No.supplement 1, 129, Aug. 2005.
29.	Masaaki Takechi, Yukihiro Momota, Youji Miyamoto, Kazuhito Satomura, Kenji Fujisawa and Masaru Nagayama : Effect of FGF-2 and Melatonin on the promotion of Osseogenesis around Titanium implants., First International Conference on Mechanics of Biomaterials &Tissues, 2005. (要約) 1
30.	Yukihiro Momota, Youji Miyamoto, Ishikawa Kunio, Masaaki Takechi, Takano Hideyuki and Masaru Nagayama : Enhancing effects aggregation of platelets by hydroxyapatite putty as a topieal hemontatie agent for bone., First International Conference on Mechanics of Biomaterials&Tissues, 2005. (要約) 1
31.	Yukihiro Momota, Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara and Masaru Nagayama : Effects of neutral sodium hydrogen phosphate on the setting property and hemostatic ability of hydroxyapatite putty as a local hemostatic agent for bone, Journal of Biomedical Materials Research. Part B, Applied Biomaterials, Vol.69B, No.1, 99-103, Apr. 2004. (要約) Hydroxyapatite (HAP) putty has been reported to have good hemostatic ability and excellent biocompatibility. Although the setting reaction of HAP putty and resulting transformation to HAP is the reason for this excellent biocompatibility, it also limits the handling period. In this study, the relationship between the setting reaction of HAP putty and its hemostatic ability was investigated, where neutral sodium hydrogen phosphate concentration and post-preparation time were used as indexes. A higher concentration of neutral sodium hydrogen phosphate was found to result in decreased hemostatic ability. The hemostatic ability of HAP putty decreased with time after its preparation; thus it was important to use HAP putty within 10 min after its preparation. The adhesive strength of HAP putty to bone increased with time. Therefore reliable hemostasis can be expected with HAP putty. Although the limited handling time is a drawback, HAP putty is thought to have a good potential as a hemostatic agent-it is highly reliable, and has a high hemostatic ability with excellent biocompatibility. (キーワード) hemostatic agents / hydroxyapatite putty / apatite cement / calcium- phosphate cement / setting reaction
32.	Hirakata Mayumi Luciana, Masayuki Kon, Tetsuya Yuasa, Youji Miyamoto and Kenzo Asaoka : Evaluation of apatite ceramics containing a-tricalcium phosphate in the surface layer, Journal of Dental Research, Vol.82, No.Spec B, 336, Goteborg, Jun. 2003.
33.	Youji Miyamoto, Yukihiro Momota, Masaaki Takechi, Tetsuya Yuasa, Seiko Tatehara, Masaru Nagayama and Kunio Ishikiawa : Effects of Neutral Sodium Hydrogen Phosphate on Setting Property and Hemostatic Ability of Hydroxyapatite Putty as a Local Hemostatic Agent for Bone, 15th International Symposium on Ceramics in Medicine, Vol.240-242, 373-376, Sydney, Dec. 2002. (キーワード) hydroxyapatite putty / haemostatic agent / bone wax / bome cement
34.	Kenzo Asaoka, Masayuki Kon, Kazuhito Satomura and Youji Miyamoto : Sintered porous titanium and Ti-6Al-4V alloys with calcium phosphate modification, Transactions of the Society for Biomaterials, Vol.28th Annual Meeting, 630, Tampa, Apr. 2002.
35.	Mayumi Luciana Hirakata, Masayuki Kon, Kenzo Asaoka, Youji Miyamoto and Masaaki Takechi : In vitro and in vivo reactions of compositional gradient bioceramics, Journal of Dental Research, Vol.80, No.Spec, 590, Chiba, Jun. 2001.
36.	Yukihiro Momota, Youji Miyamoto, K Ishikawa, Masaaki Takechi, Tetsuya Yuasa, T Toh, Masaru Nagayama and K Suzuki : Evalution of Hydroxyapatite-Putty as a Hemostatic Agent, Proceeding of the 13th Int.Symp.on Ceramics in Medicine, Vol.22-26, 849-852, Bologna, Nov. 2000. (キーワード) Apatite Cement / Bone Wax / Calcium Phosphate Cement / Hemostatic Agents
37.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Kenzo Asaoka and Masaru Nagayama : Effects of antibiotics addition on the basic properties of nd-FSCPC, Journal of Dental Research, Vol.76, No.Spec, 242, Orlando, Mar. 1997.
38.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon, Kenzo Asaoka and Masaru Nagayama : Basic properties of calcium phosphate cement containing collagen, Journal of Dental Research, Vol.76, No.Spec, 243, Orlando, Mar. 1997.
39.	Masayuki Kon, Hae-Hyoung Lee, Kunio Ishikawa, Youji Miyamoto and Kenzo Asaoka : Development of calcium phosphate cement for fast-transformation to apatite, Journal of Dental Research, Vol.76, No.Spec, 421, Orlando, Mar. 1997.
40.	Kunio Ishikawa, Youji Miyamoto, Masaaki Takechi, Masayuki Kon, Kenzo Asaoka and Masaru Nagayama : Basic properties and tissue response of hydroxyapatite putty, Journal of Dental Research, Vol.76, No.Spec, 150, Orlando, Mar. 1997.
41.	Youji Miyamoto, Kunio Ishikawa, Masaaki Takechi, Masayuki Kon and Masaru Nagayama : Soft tissue responses of calcium phosphate cements, Proceedings of the 9th International Symposium on Ceramics in Medicine, 263-266, Otsu, Nov. 1996.
42.	Masaaki Takechi, Youji Miyamoto, Kunio Ishikawa, Masayuki Kon and Masaru Nagayama : Basic properties of hydroxyapatite putty made with fast-setting calcium phosphate cement and sodium alginate, Proceedings of the 9th International Symposium on Ceramics in Medicine, 235-238, Otsu, Nov. 1996.
43.	Kunio Ishikawa, Youji Miyamoto, Masaaki Takechi, Taketomo Toh, Masayuki Kon, Masaru Nagayama and Kenzo Asaoka : Approaches for bone-replacing calcium phosphate cement, --- Effect of NaHCO3 addition on the properties of calcium phosphate cement ---, Proceedings of the 9th International Symposium on Ceramics in Medicine, 255-258, Otsu, Nov. 1996.
44.	Kunio Ishikawa, Youji Miyamoto, Masayuki Kon and Kenzo Asaoka : Non-decay type fast setting calcium phosphate cement, The 2nd International Meeting of Pacific Rim Ceramic Societies, Cairns, Jul. 1996.
45.	Kunio Ishikawa, Youji Miyamoto, Masayuki Kon and Kenzo Asaoka : Behavior of non-decay-type fast- setting calcium phosphate cement, Journal of Dental Research, Vol.75, No.Spec, 21, San Francisco, Mar. 1996.
46.	H Fukao, Youji Miyamoto, M Sawada, Masaru Nagayama, Masayuki Kon, Kunio Ishikawa and Kenzo Asaoka : In vivo reactions of functionally gradient ceramic calcium phosphate, 3rd World Congress for Oral Implantology, Yokohama, Apr. 1994.

国内講演発表:

1.	高井三和, 宮本洋二, 藤澤健司, 住友孝史, 瀧雅行, 長山勝 : 右側上顎第二乳臼歯が萌出後に歯槽骨内に埋入した1例, 第50回日本口腔科学会中国四国地方部会, (要約) 1
2.	宮本洋二, 藤澤健司, 舘原誠晃, 武知正晃, 桃田幸弘, 湯淺哲也, 長山勝, 山内英嗣, 日野出大輔 : ブローネマルクインプラントを使用した即時荷重インプラントの経験, 第47回日本口腔外科学会, (要約) 1
3.	中西宏彰, 住友孝史, 横山和博, 藤澤健司, 宮本洋二, 鎌田伸之, 長山勝 : 下顎骨骨折線上の歯に関する臨床統計学的検討, 第2回日本外傷歯学会, (要約) 1
4.	藤澤健司, 宮本洋二, 湯淺哲也, 桃田幸弘, 武知正晃, 舘原誠晃, 長山勝, 山内英嗣 : 頬骨インプラント埋入のための頬骨の計測およびpilot hole techniqueの考案, 第32回日本口腔インプラント学会, (要約) 1
5.	藤澤健司, 飛梅悟, 宮本洋二, 鎌田伸之, 長山勝 : 関節突起骨折患者の臨床統計的観察, 第15回日本顎関節学会総会, (要約) 1
6.	舘原誠晃, 宮本洋二, 武知正晃, 桃田幸弘, 湯淺哲也, 長山勝 : 骨粗鬆症ラットの仮骨延長に関する実験的研究, 第56回日本口腔科学会総会, (要約) 1
7.	前田恵利子, 藤澤健司, 中西宏彰, 桃田幸弘, 日比弓紀子, 宮本洋二, 長山勝 : 片側性下唇痩に口蓋垂裂を合供したvan der Woude症候群の1例, 第51回日本口腔科学会中国四国地方部会, (要約) 1
8.	北岡栄一郎, 中西宏彰, 宮本洋二, 鎌田伸之, 林良夫, 長山勝 : 長期にわたり経過覿察を行っている先天性舌リンパ管腫の1例, 第15回日本小児口腔外学会,
9.	住友孝史, 宮本洋二, 藤澤健司, 湯淺哲也, 長山勝, 山内英嗣, 河野文昭, 日野出大輔 : インプラントの表面形状がオッセオインテグレーション獲得に及ぼす影響一滑面と粗面インプラントの比較-, 第33回日本口腔インプラント学会総会,
10.	日比弓紀子, 宮本洋二, 藤澤健司, 桃田幸弘, 湯淺哲也, 舘原誠晃, 住友孝史, 長山勝 : インプラント安定性評価における共鳴振動周波数分析装置(Osstell)の信頼性一ペリオテストとの比較-, 第33回日本口腔インプラント学会総会,
11.	藤澤健司, 横山和博, 宮本洋二, 鎌田伸之, 長山勝 : 薬物療法を行った顎関節症患者の臨床統計的検討, 第16回日本顎関節学会総会, (要約) 1
12.	宮本洋二, 藤澤健司, 舘原誠晃, 桃田幸弘, 湯淺哲也, 長山勝 : ブローネマルクシステムを使用した即時荷重インプラントの13例, 第57回日本口腔科学会総会, (要約) 1
13.	湯淺哲也, 宮本洋二, 武知正晃, 桃田幸弘, 舘原誠晃, 長山勝, 今政幸 : カルシウム溶液処理による表面改質チタンが培養骨芽細胞に及ぼす影響, 第57回日本口腔科学会総会, (要約) 1
14.	藤澤健司, 宮本洋二, 日比弓紀子, 武知正晃, 湯淺哲也, 桃田幸弘, 舘原誠晃, 長山勝 : 水平的歯槽骨延長を行いインプラントを埋入した1例, 第34回日本口腔インプラント学会総会, (要約) 1
15.	湯淺哲也, 宮本洋二, 中西宏彰, 藤澤健司, 舘原誠晃, 瀧雅行, 長山勝 : 顔面多発骨折の変形治癒に対し顎矯正手術・骨移植術により咀嚼，審美障害の改善を認めた1例, 第6回日本口腔顎顔面外傷学会, (要約) 1
16.	藤澤健司, 湯淺哲也, 鎌田伸之, 宮本洋二, 長山勝, 北瀬由紀子, 掘内信也, 森山啓司 : 口唇口蓋裂に伴う上顎劣成長に対し，RED systemを用いて骨延長を行った2例, 第14回日本顎変形症学会総会, (要約) 1
17.	藤澤健司, 武知正晃, 山内英嗣, 宮本洋二, 湯淺哲也, 桃田幸弘, 長山勝 : 共鳴振動周波数分析装置を用いたインプラント安定性の評価1．Implant StabilityQuotient(ISQ)とインプラントの安定性に関連する因子との比較, 第35回日本口腔インプラント学会総会・学術大会, (要約) 1
18.	桃田幸弘, 宮本洋二, 石川邦夫, 南口知穂, 長山勝 : 骨止血剤(HAP putty)による血小板凝集能の亢進, 第7回日本口腔顎顔面外傷学会総会・学術大会, (要約) 1
19.	高橋章, 秋田和也, 福田直志, 髙丸菜都美, 栗尾奈愛, 菅原千恵子, 宮本洋二 : 造影CT検査による舌下動脈走行の解析, 日本歯科放射線学会第64回学術大会, Vol.64, 40, 2024年5月. (キーワード) X線CT / 歯科用インプラント / 口底 / 下顎骨舌側脈管 / 口腔出血 / 術後出血 / 舌下動脈
20.	工藤隆治, 工藤景子, 髙丸菜都美, 高橋章, 栗尾奈愛, 外礒千智, 久保亜貴子, 川中崇, 宮本洋二, 生島仁史 : 片側頸部を標的とした強度変調回転照射, 日本歯科放射線学会第64回学術大会, 2024年5月.
21.	安陪晋, 栗尾奈愛, 友竹偉則, 鎌田久美子, 大川敏永, 山内英嗣, 宮本洋二, 市川哲雄 : 下顎区域切除欠損に対して遊離腓骨皮弁による再建と広範囲顎骨支持型補綴装置を用いて機能回復を図った歯肉癌の1例, 日本口腔インプラント学会誌第43回関東・甲信越支部学術大会, 105, 2024年2月.
22.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 顎骨嚢胞摘出後に炭酸アパタイト骨補填材を充填した2例, 第27回日本顎顔面インプラント学会総会・学術大会, 2023年12月.
23.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 操作・保持性を向上した炭酸アパタイト・コラーゲンスポンジの開発と骨再建への応用, 第27回日本顎顔面インプラント学会総会・学術大会, 2023年12月.
24.	栗尾奈愛, 鎌田久美子, 上杉篤史, 横田美保, 赤井亨輔, 山村佳子, 高橋章, 宮本洋二 : ヒアルロン酸阻害薬による口腔扁平上皮癌細胞の老化誘導とsenolytic therapy, 第68回日本口腔外科学会総会・学術大会, 2023年11月.
25.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 工藤隆治, 栗尾奈愛, 宮本洋二 : 炭酸アパタイト製骨補填材の炭酸基量を変えることによる吸収性と骨新生のコントロール, 第68回日本口腔外科学会総会・学術大会, 2023年11月.
26.	福田直志, 秋田和也, 工藤景子, 石川邦夫, 宮本洋二 : 顎骨欠損に使用した炭酸アパタイト人工骨の長期経過について, 第45回日本バイオマテリアル学会大会, 2023年11月.
27.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : インプラント治療を前提とした炭酸アパタイト骨補填材を用いた骨増生法の提案, 第43回日本口腔インプラント学会中国・四国支部学術大会, 2023年10月.
28.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 顎骨嚢胞摘出後の骨欠損に使用した炭酸アパタイト骨補填材の長期経過, 第43回日本口腔インプラント学会近畿・北陸支部学術大会, 2023年10月.
29.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイト骨補填材の歯槽骨造成術への応用, 第43回日本口腔インプラント学会近畿・北陸支部学術大会, 2023年10月.
30.	野上幸裕, 福田直志, 秋田和也, 浦田豊彰, 髙丸菜都美, 工藤隆治, 高橋章, 宮本洋二 : 下顎のエナメル上皮腫と歯原性角化嚢胞のCTによる画像診断学的検討, 第70回NPO法人日本口腔科学会中国・四国地方部会, 2023年10月.
31.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイトハニカムブロックによる新規骨再建・骨造成法の開発, 第53回公益社団法人日本口腔インプラント学会学術大会, 2023年9月.
32.	髙丸菜都美, 福田直志, 栗尾奈愛, 宮本洋二 : 顎矯正手術患者の術後悪心嘔吐に対するオンダンセトロンの有用性の検討, 第33回特定非営利活動法人日本顎変形症学会総会・学術大会, 2023年6月.
33.	秋田和也, 髙丸菜都美, 福田直志, 浦田豊彰, 宮本洋二 : 術後再発をきたしたセメント芽細胞腫の1例, 第77回NPO法人日本口腔科学会学術集会, 2023年5月.
34.	山村佳子, 毛利安宏, 鎌田久美子, 栗尾奈愛, 工藤景子, 工藤保誠, 宮本洋二 : 唾液腺の発達・再生におけるNrepの役割, 第77回NPO法人日本口腔科学会学術集会, 2023年5月.
35.	浦田豊彰, 髙丸菜都美, 福田直志, 秋田和也, 宮本洋二 : 当科におけるメトトレキサート関連リンパ増殖性疾患(MTX-LPD)の臨床的検討, 第51回口腔外科学会中国四国支部学術集会(WEB開催), 2022年12月.
36.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸含有量が多孔質炭酸アパタイト顆粒の骨置換性に及ぼす影響, 第26回日本顎顔面インプラント学会総会, 2022年11月.
37.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 石川邦夫, 宮本洋二 : 炭酸含有量を調整した多孔質炭酸アパタイト顆粒による骨形成と吸収能の制御, 第44回日本バイオマテリアル学会大会, 2022年11月.
38.	福田直志, 秋田和也, 鎌田久美子, 髙丸菜都美, 工藤景子, 栗尾奈愛, 宮本洋二 : 炭酸アパタイト製骨補填材を用いた上顎洞底挙上術後の長期予後について, 公益社団法人日本口腔インプラント学会第42回中国・四国支部学術大会, 2022年11月.
39.	上杉篤史, 栗尾奈愛, 鎌田久美子, 横田美保, 工藤景子, 宮本洋二 : 機能的スクリーニングによる新規の口腔癌関連癌抑制microRNAの検索, 第67回公益社団法人日本口腔外科学会総会・学術大会, 2022年11月.
40.	山村佳子, 栗尾奈愛, 鎌田久美子, 工藤隆治, 高橋章, 工藤景子, 宮本洋二 : チタン製インプラント体のオッセオインテグレーション獲得に関与するmiRNAの検索, 第67回日本口腔外科学会総会・学術大会, 2022年11月.
41.	秋田和也, 福田直志, 髙丸菜都美, 工藤隆治, 工藤景子, 栗尾奈愛, 宮本洋二 : 炭酸基量の異なる多孔質炭酸アパタイト顆粒の開発と骨再建, 第67回日本口腔外科学会総会・学術集会, 2022年11月.
42.	鎌田久美子, 栗尾奈愛, 上杉篤史, 山村佳子, 宮本洋二 : 口腔扁平上皮癌細胞株に対するヒアルロン酸合成阻害の抗腫瘍効果, 第67回公益社団法人日本口腔外科学会総会・学術大会, 2022年11月.
43.	福田直志, 髙丸菜都美, 秋田和也, 工藤景子, 常松貴明, 石丸直澄, 宮本洋二 : 超選択的動脈塞栓術を併用して治療した上顎中心性巨細胞肉芽腫の1例, 第67回日本口腔外科学会総会・学術大会, 2022年11月.
44.	髙丸菜都美, 福田直志, 秋田和也, 工藤景子, 宮本洋二 : 3次元網状連通気孔を有する炭酸アパタイトブロックの開発, 第67回日本口腔外科学会総会・学術大会, 2022年11月.
45.	工藤景子, 福田直志, 秋田和也, 工藤隆治, 髙丸菜都美, 栗尾奈愛, 宮本洋二 : ハニカム構造を有する炭酸アパタイト多孔体によるウサギ下顎骨再建への応用, 第67回日本口腔外科学会総会・学術大会, 2022年11月.
46.	横田美保, 栗尾奈愛, 鎌田久美子, 上杉篤史, 宮本洋二 : 翼突鉤切除を行ったPterygoid hamulus bursitisの1例, 第69回(公社)日本口腔科学会中国四国支部学術集会, 2022年10月.
47.	秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイト顆粒と豚コラーゲンの複合化による新規骨補填材の開発と骨再生, 第52回公益社団法人日本口腔インプラント学会学術大会, 2022年9月.
48.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイトハニカムブロックによる新規骨造成法の開発, 第52回公益社団法人日本口腔インプラント学会学術大会, 2022年9月.
49.	宮本洋二 : なぜ，今，口腔がん検診か? -口腔がん・口腔粘膜疾患の診かた・見つけ方-, 日本歯科衛生学会第17回学術大会，教育講演，WEB開催, 2022年9月.
50.	宮本洋二 : 歯科領域における新しいバイオセラミックスのニーズと開発 ―新規骨補填材としての炭酸アパタイトの開発と骨再生医療への応用―, 日本セラミックス協会第35回秋季シンポジウム・招待講演,特定セッションH「先進セラミックバイオマテリアル研究のフロンティア ― SDGs達成を指向した医歯工学における材料機能高度制御技術の開拓と未来展望」, 2022年9月.
51.	田中茉里子, 堀内信也, 日浅雅博, 渡邉佳一郎, 岩浅亮彦, 髙丸菜都美, 永井宏和, 宮本洋二, 田中栄二 : 術後に顎関節に変調をきたした顎偏位を伴う骨格性上顎前突症例, 第32回日本顎変形症学会総会・学術大会, Vol.32, No.2, 171, 2022年6月.
52.	宮本洋二 : 新規骨補填材としての炭酸アパタイトの現状と顎骨再建・再生医療への展開, 第76回NPO法人日本口腔科学会学術集会，シンポジウム8「骨補填材のSDGsと未来」, 2022年4月.
53.	福田直志, 髙丸菜都美, 秋田和也, 工藤景子, 宮本洋二 : 炭酸アパタイトハニカムブロックの開発と外側性骨造成への応用, 第76回NPO法人日本口腔科学会学術集会, 2022年4月.
54.	宮本洋二 : 新規骨補填材としての炭酸アパタイトの現状と骨再生医療への展開, 第21回再生医療学会総会,シンポジウム13 「新しく開発された生体材料による骨再生研究の最前線」, 2022年3月.
55.	秋田和也, 福田直志, 髙丸菜都美, 工藤隆治, 工藤景子, 栗尾奈愛, 高橋章, 宮本洋二 : 炭酸アパタイト顆粒(サイトランスグラニュール)の歯槽骨造成術およびソケットプリザベーションへの応用, 第50回(公社)日本口腔外科学会中国四国支部学術集会, 2022年1月.
56.	鎌田久美子, 栗尾奈愛, 上杉篤史, 横田美保, 秋田和也, 福田直志, 山村佳子, 工藤隆治, 髙丸菜都美, 工藤景子, 高橋章, 宮本洋二 : 歯性感染症により発症した側頭部ガス壊疽の1例, 第50回(公社)日本口腔外科学会中国四国支部学術集会, 2022年1月.
57.	秋田和也, 福田直志, 椋本修平, 髙丸菜都美, 工藤景子, 都留寛治, 石川邦夫, 宮本洋二 : 炭酸基含有量の異なる多孔質炭酸アパタイト顆粒の開発, 第51回公益財団法人日本口腔インプラント学会学術大会, 2021年12月.
58.	福田直志, 秋田和也, 椋本修平, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイト製骨補填材による広範囲骨欠損の即時再建, 第51回公益財団法人日本口腔インプラント学会学術大会, 2021年12月.
59.	福田直志, 秋田和也, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイトハニカムブロックを用いたベニアグラフトの実験的検討, 第25回公益社団法人日本顎顔面インプラント学会総会・学術大会, 2021年12月.
60.	宮本洋二 : 歯科領域における新規の骨置換性バイオセラミックスのニーズと開発 -炭酸アパタイトを中心に-, 第43回日本バイオマテリアル学会大会,第8回アジアバイオマテリアル学会大会医歯薬工連携シンポジウム, 2021年11月.
61.	秋田和也, 福田直志, 鎌田久美子, 上杉篤史, 山村佳子, 工藤隆治, 髙丸菜都美, 工藤景子, 栗尾奈愛, 高橋章, 宮本洋二 : 炭酸アパタイト顆粒(サイトランスグラニュール)を用いて歯槽骨造成を行った2例, 第68 回NPO 法人日本口腔科学会中国・四国地方部会, 2021年11月.
62.	工藤隆治, 工藤景子, 生島仁史, 芳賀昭弘, 高橋章, 宮本洋二 : 片側頸部を標的とした強度変調放射線治療における線量評価:線量集中性と対側頸部・顎骨への吸収線量について, 第19 回中国四国口腔癌研究会学術集会, 2021年11月.
63.	山村佳子, 工藤保誠, 鎌田久美子, 栗尾奈愛, 横田美保, 上杉篤史, 宮本洋二 : 唾液腺の発達・再生におけるΔNp63-Nrep axisの役割, 第66回日本口腔外科学会総会・学術大会, 2021年11月.
64.	福田直志, 髙丸菜都美, 秋田和也, 椋本修平, 工藤景子, 宮本洋二 : 嚢胞摘出後の骨欠損を炭酸アパタイト製骨補填材で即時再建した1例, 第66回日本口腔外科学会総会・学術大会, 2021年11月.
65.	工藤景子, 福田直志, 秋田和也, 工藤隆治, 椋本修平, 髙丸菜都美, 栗尾奈愛, 鎌田久美子, 宮本洋二 : 炭酸アパタイト顆粒と魚うろこコラーゲンの複合化による新規骨補填材の開発, 第66回公益社団法人日本口腔外科学会総会・学術大会, 2021年11月.
66.	宮本洋二 : 口腔領域における骨補填材としての炭酸アパタイトの現状と今後の展開, 第51回日本口腔インプラント学会，シンポジウム6 「各種造成手術における既承認骨補填材を評価する」, 2021年10月.
67.	宮本洋二 : サイトランスグラニュール臨床使用3周年を迎えて, GC友の会学術講演会，東京講演会「骨再生治療の過去，現在，未来を語る -サイトランスシリーズの臨床評価と歯周組織再生治療のトレンドを知る-, 2021年7月.
68.	秋田和也, 福田直志, 鎌田久美子, 大江剛, 眞野隆充, 石川邦夫, 都留寛治, 宮本洋二 : マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発とウサギ頭蓋骨における組織学的評価, 第75回日本口腔科学会学術集会, 2021年5月.
69.	山村佳子, 工藤保誠, 毛利安宏, 卲文華, 横田美保, 宮本洋二 : 腺房細胞の再生に関わる遺伝子ネットワークの同定, 第75回日本口腔科学会学術集会, 2021年5月.
70.	椋本修平, 秋田和也, 福田直志, 髙丸菜都美, 工藤景子, 宮本洋二 : 炭酸アパタイト顆粒(サイトランスグラニュール)の嚢胞摘出術への応用, 第49回(公社)日本口腔外科学会中国四国支部学術大会, 2021年2月.
71.	秋田和也, 眞野隆充, 福田直志, 宮本洋二 : 炭酸アパタイトと豚コラーゲンの複合化による新規骨補填材の開発と骨再建への応用, 第24回日本顎顔面インプラント学会学術大会, 2020年12月.
72.	宮本洋二 : 骨補填材としての炭酸アパタイトの現状と今後の展開, 第24回日本顎顔面インプラント学会学術大会, 2020年12月.
73.	髙丸菜都美, 福田直志, 鎌田久美子, 秋田和也, 大江剛, 栗尾奈愛, 宮本洋二 : 早期口腔扁平上皮癌におけるPD-L1とZEB-1の発現と予後との関連について, 第65回日本口腔外科学会総会・学術大会, 2020年11月.
74.	福田直志, 工藤景子, 秋田和也, 工藤隆治, 髙丸菜都美, 大江剛, 栗尾奈愛, 宮本洋二 : 一方向連通気孔を有する炭酸アパタイトハニカムブロックの開発と顎骨再建への応用, 第65回日本口腔外科学会総会・学術大会, 2020年11月.
75.	上杉篤史, 津島文彦, 宮本洋二, 原田浩之 : 大根おろしによる口腔アレルギー症候群の一例, 第33回日本口腔診断学会，第30回日本口腔内科学会, 2020年10月.
76.	宮本洋二 : インプラント治療における口腔外科の基本手技とリスクマネージメント, 第50回日本口腔インプラント学会教育講演, 2020年9月.
77.	福田直志, 秋田和也, 椋本修平, 髙丸菜都美, 工藤景子, 宮本洋二 : 新規骨補填材としてのβ型リン酸三カルシウム顆粒セメントの開発と垂直的骨造成への応用, 第50回公益社団法人日本口腔インプラント学会記念学術大会, 2020年9月.
78.	友竹偉則, 石田雄一, 安陪晋, 渡邉恵, 富永賢, 松香芳三, 宮本洋二, 市川哲雄 : 徳島大学病院口腔インプラント診療部門における臨床と研究への取り組み, 日本口腔インプラント学会誌, 2020年9月.
79.	山村佳子, 眞野隆充, 栗尾奈愛, 工藤隆治, 工藤景子, 福田直志, 宮本洋二 : ピロカルピン塩酸塩を用いた口腔リンス法の有用性と安全性の検討, 第17回日本口腔ケア学会総会・学術大会, 2020年9月.
80.	宮本洋二 : サイトランスグラニュール臨床使用2周年を迎えて, GC友の会学術講演会，大阪講演会「骨再生治療の過去，現在，未来を語る -骨補填材「サイトランスグラニュール」の臨床評価とその実力-」, 2020年7月.
81.	宮本洋二 : 新規骨補填材としての炭酸アパタイト -その特徴，適応症と再生医療への展開-, 日本補綴歯科学会第129回学術大会シンポジウム5:最新の骨補填材について考える(Web開催), 2020年6月.
82.	秋田和也, 福田直志, 工藤景子, 眞野隆充, 宮本洋二 : マイクロファイバーをポロジェンとして用いた炭酸アパタイト多孔体の開発と骨再生医療への応用, 徳島県歯科医学大会, 2020年2月.
83.	宮本洋二 : 徳島大学の現状と今後の取り組み, 第1回徳島県歯科医学大会シンポジウム「徳島県における歯科医療の現状と将来」, 2020年2月.
84.	工藤景子, 秋田和也, 福田直志, 工藤隆治, 栗尾奈愛, 大江剛, 眞野隆充, 宮本洋二 : 新規骨補填材としての炭酸アパタイトの開発と骨再生医療への応用, 徳島県歯科医学大会, 2020年2月.
85.	鈴木善貴, 大倉一夫, 秋月皆人, 吉原靖智, 秋田和也, 安達聡, 田岡計久, 笠原信治, 森秀司, 宮本洋二, 松香芳三 : ウェイクボード世界大会2018における徳島大学病院・徳島県歯科医師会の歯科医療活動とマウスガードの使用実態の調査, 徳島県歯科医学大会, 2020年2月.
86.	宮本洋二, 石川邦夫 : 歯科発日本発世界初の炭酸アパタイト人工骨の開発, 日本歯学系学会協議会第17回講演会「基礎と臨床との連携」, Vol.17, 2-21, 2020年1月.
87.	宮本洋二, 石川邦夫 : 基礎と臨床との連携 -歯科発日本発世界初の炭酸アパタイト人工骨の開発-, 日本歯学系学会協議会，第17回講演会, 2020年1月.
88.	栗尾奈愛, 鎌田久美子, 横田美保, 山村佳子, 牛尾綾, 工藤保誠, 石丸直澄, 宮本洋二 : 上顎歯肉に発生した微小嚢胞性付属器癌の1例, 第38回日本口腔腫瘍学会総会・学術大会, 2020年1月.
89.	山村佳子, 大江剛, 工藤保誠, 栗尾奈愛, 鎌田久美子, 福田直志, 工藤景子, 眞野隆充, 石丸直澄, 宮本洋二 : 口腔扁平苔癬からの癌化が疑われた口腔扁平上皮癌の4例, 第38回日本口腔腫瘍学会総会・学術大会, 2020年1月.
90.	鎌田久美子, 栗尾奈愛, 大江剛, 工藤景子, 工藤保誠, 眞野隆充, 石丸直澄, 宮本洋二 : 口底に発生した類基底扁平上皮癌の1例, 第38回日本口腔腫瘍学会総会・学術大会, 2020年1月.
91.	福田直志, 工藤景子, 秋田和也, 工藤隆治, 大江剛, 眞野隆充, 宮本洋二 : 一方向連通気孔を有する炭酸アパタイトハニカムブロックの創製と新規GBR法の開発, 第23回日本顎顔面インプラント学会総会・学術大会, 2019年11月.
92.	工藤景子, 秋田和也, 工藤隆治, 福田直志, 眞野隆充, 大江剛, 林幸壱朗, 石川邦夫, 宮本洋二 : 炭酸アパタイト顆粒と魚うろこコラーゲンの複合化による新規骨補填材の創製, 第41回日本バイオマテリアル学会大会, 2019年11月.
93.	福田直志, 工藤景子, 秋田和也, 工藤隆治, 大江剛, 眞野隆充, 林幸壱朗, 石川邦夫, 宮本洋二 : 一方向連通気孔を有する炭酸アパタイトハニカムブロックの創製と下顎骨再建への応用, 第41回日本バイオマテリアル学会大会, 2019年11月.
94.	福田直志, 眞野隆充, 秋田和也, 鎌田久美子, 中島世市郎, 工藤景子, 工藤隆治, 大江剛, 宮本洋二 : 炭酸アパタイト顆粒を用いた上顎洞底拳上術症例の検討, 日本口腔インプラント学会第39回中国・四国支部学術大会, 2019年11月.
95.	秋田和也, 福田直志, 鎌田久美子, 山村佳子, 工藤景子, 工藤隆治, 栗尾奈愛, 大江剛, 眞野隆充, 宮本洋二 : ナイロンファイバーをポロゲンとして用いた炭酸アパタイト多孔体の開発と骨再建, 第64回日本口腔外科学会総会・学術大会, 2019年10月.
96.	鎌田久美子, 栗尾奈愛, 大江剛, 工藤景子, 山村佳子, 福田直志, 眞野隆充, 工藤保誠, 石丸直澄, 宮本洋二 : 上顎歯肉に発生したMicorocystic adnexal carcinoma(MAC)の1例, 第64回日本口腔外科学会総会・学術大会, 2019年10月.
97.	山村佳子, 玉谷哲也, 工藤景子, 栗尾奈愛, 鎌田久美子, 大江剛, 眞野隆充, 宮本洋二 : チタン上で培養したマウス骨芽細胞様細胞のmirVana miRNA-155-5p発現解析, 第64回日本口腔外科学会総会・学術大会, 2019年10月.
98.	工藤景子, 福田直志, 秋田和也, 工藤隆治, 大江剛, 栗尾奈愛, 山村佳子, 鎌田久美子, 眞野隆充, 宮本洋二 : ハニカム構造を有する炭酸アパタイト多孔体の開発と下顎骨再建への応用, 第64回日本口腔外科学会総会・学術大会, 2019年10月.
99.	栗尾奈愛, 鎌田久美子, 大江剛, 横田美保, 山村佳子, 工藤景子, 工藤保誠, 眞野隆充, 石丸直澄, 宮本洋二 : 歯肉腫瘤により白血病化が明らかとなった骨髄異形成症候群の1例, 第67回日本口腔科学会中国・四国地方部会, 2019年10月.
100.	工藤隆治, 工藤景子, 鎌田久美子, 福田直志, 山村佳子, 栗尾奈愛, 眞野隆充, 宮本洋二 : Radiomicsを用いた舌癌の頸部リンパ節転移の予測, 第67回日本口腔科学会中国・四国地方部会, 2019年10月.
101.	鎌田久美子, 栗尾奈愛, 大江剛, 山村佳子, 工藤景子, 工藤保誠, 石丸直澄, 宮本洋二 : 口底に発生した類基底扁平上皮癌の1例, 第18回中四国口腔癌研究会, 2019年10月.
102.	宮本洋二 : 新規骨補填材としての炭酸アパタイト顆粒の臨床応用 ‐その特徴，適応症と再生医療への展開‐, 第49回日本口腔インプラント学会学術大会企画講演, 2019年9月.
103.	大江剛, 秋田和也, 鎌田久美子, 工藤景子, 真野隆充, 石川邦夫, 宮本洋二 : 新規骨補填材としての炭酸アパタイト顆粒を用いた骨造成術の21例, 第49回日本口腔インプラント学会学術大会, 2019年9月.
104.	宮本洋二 : 新規骨補填材としての炭酸アパタイトの実用化と再生医療への展開, 再生歯科シンポジウム岡山, 2019年5月.
105.	鎌田久美子, 栗尾奈愛, 工藤景子, 山村佳子, 福田直志, 中川貴之, 大江剛, 眞野隆充, 宮本洋二 : 開口障害を主訴に来院した破傷風の1症例, 第48回(公社)日本口腔外科学会中国四国支部学術集会, 2019年5月.
106.	工藤景子, 鎌田久美子, 山村佳子, 大江剛, 栗尾奈愛, 秋田和也, 工藤隆治, 高橋章, 眞野隆充, 宮本洋二 : 上顎洞内異物迷入8症例の臨床的検討, 第48回(公社)日本口腔外科学会中国四国支部学術集会, 2019年5月.
107.	栗尾奈愛, 鎌田久美子, 山村佳子, 工藤景子, 宮本洋二 : 潰瘍性大腸炎の合併症と考えれらた難治性口腔潰瘍の一例, 第73回日本口腔科学会学術集会, 2019年4月.
108.	秋田和也, 福田直志, 鎌田久美子, 工藤隆治, 眞野隆充, 宮本洋二 : マイクロファイバーを用いた多孔質炭酸アパタオトの創製と骨再建, 第73回日本口腔科学会学術集会, 2019年4月.
109.	鈴木善貴, 大倉一夫, 秋田和也, 安達聡, 田岡計久, 笠原信治, 森秀司, 宮本洋二, 松香芳三 : ウェイクボード世界大会におけるスポーツ歯科活動, 四国歯学会第54回例会, 2019年3月.
110.	山村佳子, 玉谷哲也, 眞野隆充, 宮本洋二 : 当科における悪性リンパ腫の臨床的検討, 第37回日本口腔腫瘍学会総会・学術大会, 2019年1月.
111.	福田直志, 宮本洋二 : 生体不活性プラスチックに骨伝導性を付与できるか?, 第22回日本顎顔面インプラント学会総会・学術大会, 2018年12月.
112.	宮本洋二 : 炭酸アパタイトの開発と骨再生医療への展開, 第22回日本顎顔面インプラント学会学術大会, 2018年12月.
113.	工藤景子, 工藤隆治, 福田直志, 秋田和也, 眞野隆充, 大江剛, 中川貴之, 鎌田久美子, 宮本洋二 : 魚うろこコラーゲンと炭酸アパタイト顆粒の複合化による新規骨再建材料の開発, 第22回日本顎顔面インプラント学会総会・学術大会, 2018年12月.
114.	榊原健人, 中川貴之, 福田直志, 栗尾奈愛, 玉谷哲也, 眞野隆充, 大塚邦紘, 工藤保誠, 石丸直澄, 宮本洋二 : 下顎骨に発生した腺性歯原性嚢胞の1例, 第66回日本口腔科学会中国・四国地方部会, 2018年11月.
115.	工藤隆治, 工藤景子, 福田直志, 秋田和也, 眞野隆充, 大江剛, 中川貴之, 宮本洋二 : 炭酸アパタイト顆粒と魚うろこコラーゲンの複合化による新規骨再建材料の開発, 日本口腔インプラント学会第38回中国・四国支部学術大会, 2018年11月.
116.	大江剛, 宮本洋二 : 口腔扁平苔癬の癌化が疑われた口腔扁平上皮癌の2例, ジャパンオーラルヘルス学会第21回学術大会, 2018年11月.
117.	髙丸菜都美, 玉谷哲也, 鎌田久美子, 秋田和也, 栗尾奈愛, 中川貴之, 大江剛, 宮本洋二 : 舌扁平上皮癌におけるPD-L1とZEB-1の発現と予後との関連について, 2018年11月.
118.	福田直志, 秋田和也, 眞野隆充, 宮本洋二 : リン酸カルシウム溶液濃度が自己硬化型β-TCP顆粒セメントに及ぼす影響, 第63回日本口腔外科学会総会・学術大会, 2018年11月.
119.	山村佳子, 玉谷哲也, 工藤景子, 鎌田久美子, 工藤隆治, 栗尾奈愛, 大江剛, 髙丸菜都美, 宮本洋二 : 唾液腺の委縮により誘導される遺伝子およびマイクロRNA 発現の変化, 第63回日本口腔外科学会総会・学術大会, 2018年11月.
120.	宮本洋二 : -, 日本口腔インプラント学会第38回東北・北海道支部学術大会, 2018年10月.
121.	秋田和也, 福田直志, 鎌田久美子, 大江剛, 眞野隆充, 都留寛治, 石川邦夫, 宮本洋二 : マイクロファイバーを用いた多孔質炭酸アパタイト顆粒の開発と骨再建への応用, 第48回日本口腔インプラント学会学術大会, 2018年9月.
122.	横田美保, 大江剛, 玉谷哲也, 秋田和也, 鎌田久美子, 髙丸菜都美, 栗尾奈愛, 大塚邦紘, 工藤保誠, 宮本洋二 : 当科におけるエナメル上皮腫の臨床統計学的検討, 第47回(公社)日本口腔外科学会中国四国支部学術集会, 2018年6月.
123.	鎌田久美子, 栗尾奈愛, 工藤景子, 中川貴之, 大江剛, 秋田和也, 福田直志, 髙丸菜都美, 玉谷哲也, 眞野隆充, 宮本洋二 : 炭酸アパタイト顆粒(サイトランス○REAグラニュール)の上顎洞底挙上術への応用 -インプラント体同時埋入症例-, 第47回(公社)日本口腔外科学会中国四国支部学術集会, 2018年6月.
124.	秋田和也, 福田直志, 大江剛, 藤澤健司, 眞野隆充, 宮本洋二 : ナイロンファイバーを用いた多孔質炭酸アパタイトの開発, 第72回日本口腔科学会学術集会, 2018年5月.
125.	谷脇竜弥, 杉田知世, 村上圭史, 天羽崇, 田端厚之, 山村佳子, 玉谷哲也, 長宗秀明, 宮本洋二, 藤猪英樹 : 幼児口腔内創部より検出された多剤耐性レンサ球菌について, 四国歯学会第52回例会, 2018年3月.
126.	髙丸菜都美, 玉谷哲也, 眞野隆充, 宮本洋二 : 口腔扁平上皮癌におけるPD-L1発現と予後の検討, 第36回日本口腔腫瘍学会総会・学術大会, 2018年1月.
127.	工藤景子, 工藤隆治, 玉谷哲也, 山村佳子, 髙丸菜都美, 大江剛, 高橋章, 藤澤健司, 横田美保, 鎌田久美子, 宮本洋二 : 当科における口腔扁平苔癬症例の臨床的検討, 日本歯科人間ドック学会第20 回学術大会, 2017年12月.
128.	鎌田久美子, 藤澤健司, 工藤景子, 中川貴之, 大江剛, 秋田和也, 福田直志, 髙丸菜都美, 玉谷哲也, 眞野隆充, 宮本洋二 : 低結晶性炭酸アパタイト顆粒の上顎洞底挙上術への応用徳島大学病院におけるインプラント体同時埋入法の治験症例について, 日本顎顔面インプラント学会総会・学術大会, 2017年12月.
129.	鴨居浩平, 安陪晋, 藤澤健司, 友竹偉則, 堀川恵理子, 山内英嗣, 宮本洋二, 河野文昭 : 着脱を容易にする機構を付与したセメント固定式上部構造を用いた1症例, 第37回公益社団法人日本口腔インプラント学会, 2017年11月.
130.	秋田和也, 藤澤健司, 福田直志, 大江剛, 髙丸菜都美, 都留寛治, 石川邦夫, 宮本洋二 : 低結晶性炭酸アパタイト顆粒の顎骨再建への応用 –イヌ顎骨に埋植したインプラント体周囲における組織学的検討-, 日本口腔インプラント学会第37回中国・四国支部学術大会, 2017年11月.
131.	福田直志, 秋田和也, 鎌田久美子, 髙丸菜都美, 中川貴之, 大江剛, 藤澤健司, 宮本洋二 : 硬化遅延材としてのクエン酸が自己硬化型β-TCP顆粒セメントに及ぼす影響, 日本口腔インプラント学会第37回中国・四国支部学術大会, 2017年11月.
132.	宮本洋二, 鎌田久美子, 山村佳子, 工藤景子, 髙丸菜都美, 大江剛, 玉谷哲也, 藤澤健司, 眞野隆充 : 頸部郭清術術後のリンパ漏・乳糜漏への対応, 第65回NPO法人日本口腔科学会中国・四国地方部会, 2017年11月.
133.	鎌田久美子, 髙丸菜都美, 工藤景子, 山村佳子, 大江剛, 玉谷哲也, 眞野隆充, 宮本洋二 : 特発性血小板減少性紫斑病を有する口底癌患者の治療経験, 第65回NPO法人日本口腔科学会中国・四国地方部会, 2017年11月.
134.	山村佳子, 玉谷哲也, 工藤隆治, 鎌田久美子, 工藤景子, 髙丸菜都美, 大江剛, 藤澤健司, 中川貴之, 栗尾奈愛, 眞野隆充, 宮本洋二 : 放射線治療患者におけるピロカルピン塩酸塩を用いた口腔リンス法の有用性, 第16回中国四国口腔癌研究会, 2017年11月.
135.	宮本洋二 : 新規骨増生用バイオマテリアルとしての炭酸アパタイトの開発と薬事承認, 第62回日本口腔外科学会学術大会, 2017年10月.
136.	中川貴之, 太田耕司, 武知正晃, 宮本洋二 : 破骨細胞前駆細胞の分化におけるゾレドロン酸の標的遺伝子の網羅的探索, 第62回日本口腔外科学会学術大会, 2017年10月.
137.	髙丸菜都美, 永井宏和, 秋田和也, 工藤保誠, 石丸直澄, 宮本洋二 : 翼突下顎隙に生じた紡錐細胞脂肪腫の1例, 第62回日本口腔外科学会学術大会, 2017年10月.
138.	秋田和也, 福田直志, 大江剛, 藤澤健司, 宮本洋二 : 炭酸アパタイト・コラーゲン複合体を用いた骨再建に関する基礎的研究, 第62回日本口腔外科学会学術大会, 2017年10月.
139.	山村佳子, 玉谷哲也, 工藤景子, 福田直志, 中川貴之, 髙丸菜都美, 大江剛, 藤澤健司, 宮本洋二 : チタン上で培養したマウス骨芽細胞様細胞の硬組織分化にグルコース濃度が及ぼす影響, 第62回日本口腔外科学会学術大会, 2017年10月.
140.	福田直志, 秋田和也, 森悦秀, 宮本洋二 : 新規骨補填再建材としての自己硬化型β-TCP顆粒セメントの開発, 第62回日本口腔外科学会学術大会, 2017年10月.
141.	大江剛, 髙丸菜都美, 中川貴之, 玉谷哲也, 秋田和也, 宮本洋二 : 免疫チェックポイント阻害剤抗PD-L1抗体とOK-432の併用による口腔癌に対する抗腫瘍効果, 第62回日本口腔外科学会学術大会, 2017年10月.
142.	宮本洋二 : 骨補填材としての炭酸アパタイトの開発と薬事承認に向けて, 第47回日本口腔インプラント学会学術大会, 2017年9月.
143.	秋田和也, 福田直志, 大江剛, 藤澤健司, 宮本洋二, 都留寛治, 石川邦夫 : 新規骨再生材料としての炭酸アパタイト・コラーゲン複合体の開発, 第47回日本口腔インプラント学会学術大会, 2017年9月.
144.	藤澤健司, 秋田和也, 福田直志, 大江剛, 髙丸菜都美, 都留寛治, 石川邦夫, 宮本洋二 : 低結晶性炭酸アパタイト顆粒の骨再生への応用 –ウサギ大腿骨内における組織学的検討‐, 第47回日本口腔インプラント学会学術大会, 2017年9月.
145.	横田美保, 工藤景子, 玉谷哲也, 鎌田久美子, 福田直志, 髙丸菜都美, 山村佳子, 中川貴之, 大江剛, 工藤隆治, 高橋章, 藤澤健司, 鯨岡聡子, 工藤保誠, 石丸直澄, 宮本洋二 : 当科における歯原性角化嚢胞の臨床的検討, 第46回日本口腔外科学会中国四国学術集会, 2017年5月.
146.	秋田和也, 髙丸菜都美, 玉谷哲也, 鎌田久美子, 山村佳子, 工藤景子, 大江剛, 藤澤健司, 宮本洋二 : 当科における手術拒否口腔癌症例の臨床的検討, 第46回日本口腔外科学会中国四国学術集会, 2017年5月.
147.	高橋章, 工藤隆治, 工藤景子, 髙丸菜都美, 大江剛, 玉谷哲也, 藤澤健司, 菅原千恵子, 宮本洋二 : 咽頭扁桃結石に関するX線診断学的検討, 第71回NPO法人日本口腔科学会学術集会, 2017年4月.
148.	玉谷哲也, 髙丸菜都美, 大江剛, 高橋章, 藤澤健司, 宮本洋二 : 早期口腔扁平上皮癌患者におけるABCG2，ALDH1，Bmi-1，CD24およびCD44発見に関する検討, 第71回NPO法人日本口腔科学会学術集会, 2017年4月.
149.	山村佳子, 藤澤健司, 工藤隆治, 工藤景子, 秋田和也, 中村勇貴, 髙丸菜都美, 大江剛, 玉谷哲也, 宮本洋二 : ピロカルピン塩酸塩(サラジェン)を用いた口腔リンス法の有効性と安全性の検討, 第14回日本口腔ケア学会総会・学術大会, 2017年4月.
150.	髙丸菜都美, 玉谷哲也, 永井宏和, 宮本洋二 : 早期口腔扁平上皮癌患者におけるCD20の発現に関する検討, 第35回日本口腔腫瘍学会総会・学術大会, 2017年1月.
151.	工藤景子, 鎌田久美子, 横田美保, 髙丸菜都美, 山村佳子, 大江剛, 工藤隆治, 高橋章, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 当科における口腔がん検診の現況, 日本歯科人間ドック学会第19回学術大会, 2016年12月.
152.	大江剛, 藤澤健司, 永井宏和, 宮本洋二 : 低結晶性炭酸アパタイトを用いた骨再建に関する基礎的研究, 第20回公益社団法人日本顎顔面インプラント学会総会・学術大会, 2016年12月.
153.	仙頭慎哉, 北村直也, 山本哲也, 浜川裕之, 佐々木朗, 宮本洋二, 両家和男, 上山吉哉 : 口腔癌に対する化学療法におけるパロノセトロンの悪心・嘔吐予防効果, 第61回(公社)日本口腔外科学会総会・学術大会, 2016年11月.
154.	山之内浩司, 工藤景子, 小暮大地, 宮本洋二 : 過去10年間における抗血栓療法下でのインプラント治療に対する臨床的検討, 第61回(公社)日本口腔外科学会総会・学術大会, 2016年11月.
155.	山村佳子, 玉谷哲也, 大江剛, 藤澤健司, 髙丸菜都美, 工藤景子, 永井宏和, 宮本洋二 : チタン上で培養したヒト骨髄間葉系幹細胞の遺伝子およびmicroRNA発現の解析, 第61回(公社)日本口腔外科学会総会・学術大会, 2016年11月.
156.	髙丸菜都美, 鎌田久美子, 工藤景子, 玉谷哲也, 山村佳子, 大江剛, 永井宏和, 宮本洋二 : 口腔内に発生したメトトレキサート関連リンパ増殖性疾患の2例, 第61回(公社)日本口腔外科学会総会・学術大会, 2016年11月.
157.	山村佳子, 玉谷哲也, 大江剛, 藤澤健司, 髙丸菜都美, 工藤景子, 永井宏和, 宮本洋二 : チタンが培養ヒト骨髄間葉系幹細胞に及ぼす影響 –マイクロアレイによる解析-, 日本バイオマテリアル学会シンポジウム2016, 2016年11月.
158.	堀川恵理子, 安陪晋, 藤澤健司, 高橋章, 山内英嗣, 友竹偉則, 宮本洋二, 河野文昭 : 単独歯インプラントの隣在歯の生存率に関する調査, 日本口腔インプラント学会中国・四国支部学術大会, 45, 2016年11月.
159.	鎌田久美子, 高橋章, 大江剛, 髙丸菜都美, 藤澤健司, 永井宏和, 安陪晋, 宮本洋二 : CT画像による副オトガイ孔の発現頻度に関する検討, 日本口腔インプラント学会中国・四国歯部学術大会, 33, 2016年11月.
160.	玉谷哲也, 髙丸菜都美, 鎌田久美子, 横田美保, 山村佳子, 工藤景子, 大江剛, 工藤隆治, 高橋章, 藤澤健司, 永井宏和, 宮本洋二 : 当科における早期口腔扁平上皮癌患者の臨床的検討, 第64回NPO法人日本口腔科学会中国・四国地方部会, 2016年10月.
161.	横田美保, 藤澤健司, 山村佳子, 玉谷哲也, 髙丸菜都美, 工藤景子, 大江剛, 永井宏和, 鯨岡聡子, 石丸直澄, 宮本洋二 : 骨破壊を伴った顎放線菌症の2例, 第64回NPO法人日本口腔科学会中国・四国地方部会, 2016年10月.
162.	高橋章, 鎌田久美子, 山村佳子, 髙丸菜都美, 工藤隆治, 工藤景子, 大江剛, 藤澤健司, 玉谷哲也, 永井宏和, 宮本洋二 : 口腔扁平上皮癌の頸部リンパ節転移診断におけるFDG-PET検査の有用性, 第15回中国四国口腔癌研究会, 2016年10月.
163.	玉谷哲也, 髙丸菜都美, 永井宏和, 宮本洋二 : 口腔扁平上皮癌におけるSOX2発現の臨床病理学的意義, 第75回日本癌学会学術大会総会, 2016年10月.
164.	藤澤健司, 永井宏和, 髙丸菜都美, 都留寛治, 石川邦夫, 宮本洋二 : 低結晶性炭酸アパタイトのインプラント領域への応用 –イヌ顎骨への印プラント体との同時埋植-, 第46回公益社団法人日本口腔インプラント学会学術大会, 2016年9月.
165.	大江剛, 小林真左子, 藤澤健司, 永井宏和, 宮本洋二 : 炭酸アパタイト被膜炭酸カルシウムを用いた新規骨置換材料による骨再生の試み, 第46回公益社団法人日本口腔インプラント学会学術大会, 2016年9月.
166.	工藤隆治, 工藤景子, 高橋章, 宮本洋二 : 口腔癌に対する強度変調放射線治療の有効性について, NPO法人日本歯科放射線学会第57回学術大会・第13回定例総会, 2016年6月.
167.	鎌田久美子, 工藤景子, 玉谷哲也, 髙丸菜都美, 山村佳子, 大江剛, 藤澤健司, 永井宏和, 宮本洋二 : 舌に発生したメトトレキサート関連リンパ増殖性疾患の1例, 第45回(公社)日本口腔外科学会中国四国支部学術大会, 2016年5月.
168.	大江剛, 鎌田久美子, 髙丸菜都美, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 頬粘膜に発生した基底細胞腺腫の1例, 第45回(公社)日本口腔外科学会中国四国支部学術大会, 2016年5月.
169.	高橋章, 工藤隆治, 工藤景子, 髙丸菜都美, 大江剛, 玉谷哲也, 永井宏和, 藤澤健司, 宮本洋二 : 硬口蓋を基準とした後上歯槽動脈の走行に関する検討, 第70回NPO法人日本口腔科学会学術集会, 2016年4月.
170.	工藤隆治, 玉谷哲也, 藤澤健司, 工藤景子, 髙丸菜都美, 永井宏和, 宮本洋二 : 口腔癌に対する強度変調放射線治療に関する臨床的検討, 第34回日本口腔腫瘍学会総会・学術大会, 2016年1月.
171.	菅原千恵子, 高橋章, 工藤隆治, 河野文昭, 宮本洋二 : 歯科受診を契機にして発見された他科領域の悪性疾患症例, 日本歯科放射線学会第35回関西・九州合同地方会, 2015年12月.
172.	山村佳子, 藤澤健司, 宮本洋二 : 口腔がん患者の歯科疾患罹患状況, 第18回日本歯科人間ドック学会・学術大会, 2015年12月.
173.	大江剛, 鎌田久美子, 藤澤健司, 永井宏和, 宮本洋二 : 低結晶性炭酸アパタイトを用いた骨再生療法に関する基礎的研究, 第19回日本顎顔面インプラント学会学術大会, 2015年11月.
174.	藤澤健司, 永井宏和, 髙丸菜都美, 大江剛, 都留寛治, 石川邦夫, 宮本洋二 : ゼラチン複合型炭酸アパタイトフォームの物理学的評価, 第37回日本バイオマテリアル学会大会, 2015年11月.
175.	高橋章, 菅原千恵子, 工藤隆治, 工藤景子, 髙丸菜都美, 大江剛, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 舌扁桃結石に関するX線診断学的検討, 第63回NPO法人日本口腔科学会中国・四国地方部会, 2015年11月.
176.	藤澤健司, 大江剛, 髙丸菜都美, 玉谷哲也, 山村佳子, 工藤景子, 永井宏和, 宮本洋二 : 上顎洞底挙上術を併用したインプラントの予後に関する臨床的検討, 第63回NPO法人日本口腔科学会中国・四国地方部会, 2015年11月.
177.	玉谷哲也, 髙丸菜都美, 大江剛, 永井宏和, 宮本洋二 : 口腔扁平上皮癌におけるCD44,ABCG2およびALDH1の発現に関する検討, 第60回公益社団法人日本口腔外科学会総会・学術大会, 2015年10月.
178.	永井宏和, 藤澤健司, 大江剛, 小林真左子, 髙丸菜都美, 工藤隆治, 玉谷哲也, 宮本洋二 : 低結晶性炭酸アパタイトの骨再建への応用第1報イヌ歯槽骨欠損部への移植, 第60回公益社団法人日本口腔外科学会総会・学術大会, 2015年10月.
179.	髙丸菜都美, 大江剛, 玉谷哲也, 永井宏和, 宮本洋二 : 静脈性血管奇形に対するNd:YAGレーザーを用いた光凝固療法, 第60回公益社団法人日本口腔外科学会総会・学術大会, 2015年10月.
180.	玉谷哲也, 髙丸菜都美, 大江剛, 永井宏和, 宮本洋二 : 口腔癌におけるBmi-1とCD24発現の臨床病理病理学的意義, 第74回日本癌学会学術総会, 2015年10月.
181.	永井宏和, 藤澤健司, 都留寛治, 石川邦夫, 宮本洋二 : 低結晶性炭酸アパタイトの骨再建への応用イヌ顎骨に作製した骨欠損部への移植, 第45回公益社団法人日本口腔インプラント学会学術大会, 2015年9月.
182.	宮本洋二 : 外科の新しい概念および手術手技, 四国歯学会第47回例会, 2015年6月.
183.	高橋章, 菅原千恵子, 工藤隆治, 工藤景子, 髙丸菜都美, 大江剛, 玉谷哲也, 永井宏和, 宮本洋二 : 口蓋扁桃結石に関するX線診断学的検討 -パノラマX線写真における描出状況, 第69回日本口腔科学会学術集会, 2015年5月.
184.	鎌田久美子, 栗林伸行, 髙丸菜都美, 大江剛, 玉谷哲也, 永井宏和, 藤澤健司, 宮本洋二 : 超選択的動注化学療法が奏功した頸部リンパ節転移を伴った下顎歯肉癌の1例, 第44回(公社)日本口腔外科学会中国四国支部学術集会, 2015年4月.
185.	小林真左子, 栗林伸行, 玉谷哲也, 永井宏和, 宮本洋二 : 下顎に発生したエナメル上皮線維象牙質腫の一例, 第33回日本口腔腫瘍学会学術大会, 2015年1月.
186.	鎌田久美子, 大江剛, 藤澤健司, 永井宏和, 宮本洋二 : インプラントの経過不良により来科したビスフォスフォネート製剤投与患者の臨床的検討, 公益社団法人日本口腔外科学会・学術大会第34回中国・四国支部学術大会, 2014年11月.
187.	宮本洋二 : インプラント治療の良い点，悪い点, 公益社団法人日本口腔外科学会・学術大会第34回中国・四国支部学術大会, 2014年11月.
188.	小林真左子, 永井宏和, 藤澤健司, 都留寛治, 石川邦夫, 山中克之, 熊谷知宏, 宮本洋二 : 炭酸アパタイト被覆炭酸カルシウムを用いたハイブリッド型骨補填材料による骨再生の試み, 第36回日本バイオマテリアル学会大会, 2014年11月.
189.	工藤景子, 玉谷哲也, 髙丸菜都美, 木内誠, 鎌田久美子, 永井宏和, 高石和美, 宮本洋二 : 水酸化カルシウム系根管充填材料の根尖外溢出により下歯槽神経麻痺が生じた1例, 第62回NPO法人日本口腔科学会中国・四国地方部会, 2014年10月.
190.	工藤隆治, 栗林伸行, 工藤景子, 大江剛, 小林真左子, 玉谷哲也, 永井宏和, 近藤智之, 石丸直澄, 宮本洋二 : 舌に発生した孤立性神経線維腫の1例, 第62回NPO法人日本口腔科学会中国・四国地方部会, 2014年10月.
191.	工藤景子, 玉谷哲也, 髙丸菜都美, 木内誠, 鎌田久美子, 永井宏和, 高石和美, 宮本洋二 : 水酸化カルシウム系根管充填材料の根尖外溢出により下歯槽神経麻痺が生じた1例, 第62回NPO法人日本口腔科学会中国・四国地方部会, 2014年10月.
192.	小林真左子, 永井宏和, 原香苗, 鎌田久美子, 工藤隆治, 藤澤健司, 宮本洋二 : 炭酸アパタイト被膜炭酸カルシウムを用いた新規骨置換材料による骨再生の試み, 第59回(公社)日本口腔外科学会総会・学術大会, 2014年10月.
193.	小林真左子, 永井宏和, 原香苗, 鎌田久美子, 工藤隆治, 藤澤健司, 宮本洋二 : 炭酸アパタイト被膜炭酸カルシウムを用いた新規骨置換材料による骨再生の試み, 第59回(公社)日本口腔外科学会総会・学術大会, 2014年10月.
194.	菅原千恵子, 高橋章, 河野文昭, 宮本洋二 : 歯科領域における超音波検査の現状, 日本超音波医学会第24回四国地方会学術集会, 2014年10月. (キーワード) 口腔悪性腫瘍 / 頸部リンパ節転移
195.	玉谷哲也, 髙丸菜都美, 木内誠, 栗林伸行, 内田大亮, 永井宏和, 宮本洋二 : 口腔癌におけるABCG2とALDH1A1発現の臨床病理学的意義, 第73回日本癌学会学術総会, 2014年9月.
196.	木内誠, 内田大亮, 栗林伸行, 玉谷哲也, 永井宏和, 宮本洋二 : miR-518c-5pの口腔癌におけるmetastamiRとしての可能性, 第6回日本RNAi研究会, 2014年8月.
197.	藤澤健司, 宮本洋二, 山本愛美, 和田明人, 早雲講二, 安田勝裕, 齋賀洋二, 福井一裕, 齋賀明彦, 日下淳, 槇大, 川島周, 神山有史, 笠井祥資, 石上安希子, 西村明儒 : 徳島県における合同遺体対応訓練-歯科医師と他職種の連携について-．, 第13回警察歯科医会全国大会, 95, 2014年8月.
198.	鎌田久美子, 大江剛, 工藤隆治, 永井宏和, 宮本洋二 : 舌根部に発生した骨性分離腫の1例, 第68回NPO法人日本口腔科学会学術集会, 2014年5月.
199.	木内誠, 内田大亮, 栗林伸行, 玉谷哲也, 永井宏和, 宮本洋二 : CXCR4システムにより誘導されるmiR-518c-5pの口腔癌における転移関連microRNAとしての可能性, 第68回NPO法人日本口腔科学会学術集会, 2014年5月.
200.	高橋章, 栗林伸行, 工藤隆治, 内田大亮, 玉谷哲也, 永井宏和, 宮本洋二 : 口腔癌の頸部リンパ節マッピングによる頸部リンパ節転移診断精度の検討, 日本口腔外科学会中国四国支部学術大会徳島, 2014年4月.
201.	小林真左子, 栗林伸行, 内田大亮, 玉谷哲也, 永井宏和, 宮本洋二 : 口腔領域にみられた転移性癌の臨床的検討, 32回日本口腔腫瘍学会学術集会, 2014年1月.
202.	鎌田久美子, 大江剛, 藤澤健司, 内田大亮, 宮本洋二 : 吸収性メッシュと骨髄海綿骨細片骨移植で再建した上顎前歯部にインプラント治療を行った1例, 第17回日本顎顔面インプラント学会学術大会, 2013年11月.
203.	鎌田久美子, 大江剛, 藤澤健司, 内田大亮, 宮本洋二 : 吸収性メッシュと骨髄海綿骨細片骨移植で再建した上顎前歯部にインプラント治療を行った1例, 第17回日本顎顔面インプラント学会学術大会, 2013年11月.
204.	永井宏和, 原香苗, 小林真左子, 藤澤健司, 都留寛治, 山本克史, 石川邦夫, 宮本洋二 : 低結晶性炭酸アパタイトの顎骨再建への応用に関する基礎的研究第6報 BMP-2との併用効果, 第35回日本バイオマテリアル学会大会, 2013年11月.
205.	小林真左子, 藤澤健司, 大江剛, 大倉一夫, 安陪晋, 内田大亮, 永井宏和, 宮本洋二 : 当科における過去 20 年間のインプラント脱落症例の検討―early failure と late failure の比較―, 第33回口腔インプラント学会中国・四国支部学術集会, 2013年11月.
206.	安陪晋, 藤澤健司, 山本修史, 河野文昭, 宮本洋二 : サイナスリフトと同時に即時加重インプラント治療を行った1症例, 公益社団法人日本口腔インプラント学会第33回中国四国支部総会学術大会, 2013年11月.
207.	小林真左子, 藤澤健司, 大江剛, 安陪晋, 大倉一夫, 内田大亮, 永井宏和, 宮本洋二 : 当科における過去 20 年間のインプラント脱落症例の検討―early failure と late failure の比較―, 第33回口腔インプラント学会中国・四国支部学術集会, 2013年11月.
208.	藤澤健司, 工藤隆治, 小林真左子, 工藤景子, 玉谷哲也, 永井宏和, 宮本洋二 : 下顎枝垂直骨切り術後の下顎頭位変化の検討, 第61回NPO法人日本口腔科学会中国・四国地方部会, 2013年11月.
209.	工藤隆治, 藤澤健司, 工藤景子, 小林真左子, 栗林伸行, 髙丸菜都美, 大江剛, 内田大亮, 髙橋章, 玉谷哲也, 永井宏和, 生島仁史, 宮本洋二 : 当科における強度変調放射線治療(IMRT)の経験, 第12回中国四国口腔癌研究会学術講演会, 2013年11月.
210.	玉谷哲也, 髙丸菜都美, 小林真左子, 栗林伸行, 大江剛, 内田大亮, 藤澤健司, 永井宏和, 宮本洋二 : 当科を受診した悪性リンパ腫の臨床的検討, 第58回(公社)日本口腔外科学会総会・学術大会, 2013年10月.
211.	髙丸菜都美, 鎌田久美子, 永井宏和, 宮本洋二 : 舌から喉頭蓋前間隙へ移動した迷入魚骨の1例, 第58回(公社)日本口腔外科学会総会・学術大会, 2013年10月.
212.	小林真左子, 工藤景子, 栗林伸行, 永井宏和, 宮本洋二 : 顎関節に生じた頭蓋底まで及んだ偽痛風の1例, 第58回(公社)日本口腔外科学会総会・学術大会, 2013年10月.
213.	栗林伸行, 内田大亮, 木内誠, 玉谷哲也, 永井宏和, 宮本洋二 : CXCR4システムを介した口腔癌のリンパ節転移におけるmGluR5のリンパ管新生への関与, 第58回(公社)日本口腔外科学会総会・学術大会, 2013年10月.
214.	玉谷哲也, 髙丸菜都美, 木内誠, 栗林伸行, 内田大亮, 永井宏和, 宮本洋二 : 口腔癌におけるNF-κB 発現の臨床病理学的意義, 第72回日本癌学会学術大会総会, 2013年10月.
215.	栗林伸行, 内田大亮, 木内誠, 玉谷哲也, 永井宏和, 宮本洋二 : CXCR4伝達経路によるmGluR5の転写調節機構, 第72回日本癌学会学術大会総会, 2013年10月.
216.	木内誠, 内田大亮, 栗林伸行, 玉谷哲也, 永井宏和, 宮本洋二 : 口腔癌におけるCXCR4システムにより誘導される新規転移関連microRNAの同定, 第72回日本癌学会学術大会総会, 2013年10月.
217.	鎌田久美子, 藤澤健司, 大江剛, 永井宏和, 宮本洋二 : オッセオインテグレーション獲得前のインプラント脱落症例の検討-最近10年間とそれ以前の症例との比較-, 第43回公益社団法人日本口腔インプラント学会学術大会, 2013年9月.
218.	木内誠, 内田大亮, 栗林伸行, 玉谷哲也, 永井宏和, 宮本洋二 : stromal-cell derived factor (SDF)-1/CXCR4システムにより誘導される口腔癌の転移関連マイクロRNAの検索, 第5回日本RNAi研究会, 2013年8月.
219.	小林真左子, 栗林伸行, 髙丸菜都美, 工藤景子, 大江剛, 内田大亮, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 当科における過去8年間の下顎関節突起骨折の臨床的検討, 第15回口腔顎顔面外傷学会学術大会, 2013年7月.
220.	堀内信也, 泰江章博, 川合暢彦, 黒田晋吾, 宮本洋二, 田中栄二 : 先端巨大症に起因した骨格性下顎前突症に対し舌縮小術を併用して外科的矯正治療を行った1例, 第23回日本顎変形症学会大会, 2013年6月.
221.	髙丸菜都美, 永井宏和, 大江剛, 内田大亮, 玉谷哲也, 藤澤健司, 宮本洋二 : 当科におけるビスフォスフォネート関連顎骨壊死(BRONJ)患者の臨床的検討, 第67回NPO法人日本口腔科学会学術集会, 2013年6月.
222.	木内誠, 内田大亮, 栗林伸行, 玉谷哲也, 永井宏和, 宮本洋二 : Stromal-cell derived factor(SDF)-1/CXCR4システムにより誘導される口腔癌の転移関連マイクロRNAの検索, 第37回日本頭頸部癌学会, 2013年6月.
223.	高橋章, 工藤隆治, 菅原千恵子, 宮本洋二 : 口蓋扁桃石灰化に関するX線診断学的検討 -CTにおける描出状況-, 第54回NPO法人日本歯科放射線学会学術大会, 2013年6月.
224.	髙丸菜都美, 永井宏和, 大江剛, 内田大亮, 玉谷哲也, 藤澤健司, 宮本洋二 : 当科におけるビスフォスフォネート関連顎骨壊死(BRONJ)患者の臨床的検討, 第67回NPO法人日本口腔科学会学術集会, 2013年5月.
225.	小林真左子, 宮本洋二, 井関祥子 : BMP2の骨誘導に対するFGFファミリーの併用効果, 第67回NPO法人日本口腔科学会学術集会, 2013年5月.
226.	鎌田久美子, 工藤景子, 小林真左子, 栗林伸行, 髙丸菜都美, 大江剛, 内田大亮, 玉谷哲也, 藤澤健司, 永井宏和, 安田勝裕, 横山正秋, 宮本洋二 : 徳島県における口腔がん検診と口腔がん啓発のための活動状況, 第42回(公社)日本口腔外科学会中四国支部学術集会, 2013年4月.
227.	小林真左子, 髙丸菜都美, 玉谷哲也, 内田大亮, 大江剛, 永井宏和, 宮本洋二 : ナビゲーションシステムを用いて腫瘍切除を行い，腸骨移植とインプラントで再建した骨形成線維腫の1例, 第42回(公社)日本口腔外科学会中四国支部学術集会, 2013年4月.
228.	木内誠, 内田大亮, 栗林伸行, 永井宏和, 玉谷哲也, 宮本洋二 : stromal-cell derived factor (SDF)-1/CXCR4システムにより誘導される口腔癌の転移関連マイクロRNAの同定, 第31回日本口腔腫瘍学会総会・学術大会, 2013年1月.
229.	栗林伸行, 永井宏和, 内田大亮, 木内誠, 玉谷哲也, 藤澤健司, 石丸直澄, 宮本洋二 : 頬粘膜に生じた明細胞癌NOSの1例, 第31回日本口腔腫瘍学会総会・学術大会, 2013年1月.
230.	原香苗, 永井宏和, 都留寛治, 石川邦夫, 宮本洋二 : ゼラチン複合型炭酸アパタイトフォームの創製, 日本バイオマテリアルシンポジウム2012, 2012年11月.
231.	山本修史, 大江剛, 藤澤健司, 永井宏和, 宮本洋二 : ナビゲーションシステムを用いた下顎骨辺縁切除術後に骨移植とインプラント治療を行った骨形成線維腫の1例, 第32回日本口腔インプラント学会中国・四国支部学術大会, 2012年11月.
232.	宮本洋二 : シンポジウムテーマ:「インプラントの光と影 ‐この10年とこれからの10年‐」私のインプラント治療の進化と淘汰, 第32回日本口腔インプラント学会中国・四国支部学術大会, 2012年11月.
233.	小林真左子, 宮本洋二, 井関祥子 : 新規徐放性ナノゲルを用いたFGF18によるBMP2依存的な骨修復能の改良, 第57回公益社団法人日本口腔外科学会, 2012年10月.
234.	永井宏和, 藤澤健司, 髙丸菜都美, 内田大亮, 玉谷哲也, 大江剛, 石丸直澄, 宮本洋二 : 頬部に生じた粘液種の1例, 第57回公益社団法人日本口腔外科学会, 2012年10月.
235.	玉谷哲也, 髙丸菜都美, 栗林伸行, 大江剛, 内田大亮, 永井宏和, 宮本洋二 : 口腔扁平上皮癌におけるXIAPの発現に関する検討, 第57回公益社団法人日本口腔外科学会, 2012年10月.
236.	栗林伸行, 内田大亮, 木内誠, 玉谷哲也, 永井宏和, 宮本洋二 : SDF-1/CXCR4システムを介した口腔癌のリンパ節転移におけるmGluR5の臨床病理学的意義, 第57回公益社団法人日本口腔外科学会, 2012年10月.
237.	小林真左子, 宮本洋二, 井関祥子([東京医科歯科大学医歯学総合研究科分子発生学分野 : 新規徐放性ナノゲルを用いたFGF18によるBMP2依存的な骨修復能の改良, 第57回公益社団法人日本口腔外科学会, 2012年10月.
238.	鈴木悠, 大江剛, 髙丸菜都美, 内田大亮, 玉谷哲也, 永井宏和, 宮本洋二 : 抜歯後疼痛を対象としたセレコキシブの有効性および安全性の検討, 第60回NPO法人日本口腔科学会中国・四国地方部会, 2012年10月.
239.	栗林伸行, 内田大亮, 木内誠, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 口腔への転移性癌に関する臨床的検討, 第11回中国四国口腔癌研究会学術講演会, 2012年10月.
240.	藤澤健司, 大江剛, 内田大亮, 永井宏和, 宮本洋二 : 上部構造装着後のインプラント脱落症例の検討ー滑面と粗面インプラントの比較ー, 第42回日本口腔インプラント学会, 2012年9月.
241.	Makoto Kinouchi, Daisuke Uchida, Nobuyuki Kuribayashi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Role of mGluR5 on the lymph node metastases of oral cancer by the SDF-1/CXCR4 system in salivary gland adenoid cystic carcinoma, 第71回日本癌学会学術総会, Sep. 2012.
242.	Nobuyuki Kuribayashi, Daisuke Uchida, Makoto Kinouchi, Tetsuya Tamatani, Hirokazu Nagai and Youji Miyamoto : Role of mGluR5 on the lymph node metastases of oral cancer by the SDF-1/CXCR4 system, 第71回日本癌学会学術総会, Sep. 2012.
243.	髙丸菜都美, 鎌田久美子, 大江剛, 内田大亮, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 口腔癌術後補助化学療法としてのS-1の短期成績, 第66回日本口腔科学会学術集会, 2012年5月.
244.	大江剛, 小出真理子, 髙丸菜都美, 内田大亮, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 下顎枝垂直骨切り術のためのCTを用いた下顎枝形態の検討, 第66回日本口腔科学会学術集会, 2012年5月.
245.	原香苗, 永井宏和, 栗林伸行, 山本修史, 髙丸菜都美, 大江剛, 内田大亮, 玉谷哲也, 藤澤健司, 宮本洋二 : 当科における悪性リンパ腫の臨床的検討, 第41回(社)日本口腔外科学会中・四国地方会, 2012年4月.
246.	佐藤裕子, 髙丸菜都美, 大江剛, 内田大亮, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 当科におけるビスフォスフォネート関連顎骨壊死(BRONJ)患者の臨床的検討, 第41回(社)日本口腔外科学会中・四国地方会, 2012年4月.
247.	内田大亮, 大江剛, 栗林伸行, 永井宏和, 宮本洋二 : 抗血栓療法継続下にNd-YAGレーザーによる光凝固療法を行った舌血管腫の一例, 有病者歯科医療学会, 2012年3月.
248.	栗林伸行, 内田大亮, 玉谷哲也, 永井宏和, 宮本洋二 : ヒト唾液腺癌におけるケモカインレセプターCXCR4 の発現と機能的役割, 第30回日本口腔腫瘍学会学術大会, 2012年1月.
249.	藤澤健司, 大江剛, 内田大亮, 髙丸菜都美, 玉谷哲也, 永井宏和, 宮本洋二 : ショートインプラントの生存率に関する臨床的検討, 第15回日本学顔面インプラント学会, 2011年12月.
250.	木内誠, 藤澤健司, 髙丸菜都美, 大江剛, 内田大亮, 玉谷哲也, 永井宏和, 藤原慎視, 田中栄二, 宮本洋二 : 下顎枝矢状分割骨切り術と下顎枝垂直骨切り術の術後安定性に関する検討, 第59回NPO法人日本口腔科学会中国・四国地方部会, 2011年11月.
251.	小出真理子, 大江剛, 髙丸菜都美, 内田大亮, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 術前CTを用いた下顎枝の形態学的検討, 第59回NPO法人日本口腔科学会中国・四国地方部会, 2011年10月.
252.	鎌田久美子, 髙丸菜都美, 大江剛, 内田大亮, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : S-1による術後補助化学療法に関する検討, 第10回中四国口腔癌研究会学術講演会, 2011年10月.
253.	髙丸菜都美, 永井宏和, 大江剛, 内田大亮, 玉谷哲也, 石丸直澄, 宮本洋二 : 下顎骨に発生した歯原性粘液腫の1例, 第 56回日本口腔外科学会総会・学術大会, 2011年10月.
254.	内田大亮, 栗林伸行, 玉谷哲也, 永井宏和, 宮本洋二 : SDF-1/CXCR4システムを介した口腔癌のリンパ節転移におけるmGluR5によるVEGFCの誘導, 第 56回日本口腔外科学会総会・学術大会, 2011年10月.
255.	川上恵実, 堀内信也, 松田りえ, 内田玲子, 黒田晋吾, 宮本洋二, 天真覚, 田中栄二 : 骨格性開咬症に対する下顎骨の反時計方向を伴う外科的下顎骨移動術の長期安定性:15年経過症例, 第70回日本矯正歯科学会学術大会, 322, 2011年10月.
256.	川上恵実, 堀内信也, 松田りえ, 内田玲子, 黒田晋吾, 宮本洋二, 天真覚, 田中栄二 : 骨格性開咬症に対する下顎骨の反時計方向を伴う外科的下顎骨移動術の長期安定性:15年経過症例, 第70回日本矯正歯科学会学術大会, 2011年10月.
257.	宮本洋二 : 骨置換性の新規骨補填材料の開発-炭酸アパタイトの臨床応用に向けて-, 第31回日本口腔インプラント学会中国・四国支部総会・学術大会, 2011年10月.
258.	山本修史, 大江剛, 藤澤健司, 永井宏和, 宮本洋二 : コンピュータ支援手術システムを用いたインプラント手術の経験, 第31回公益社団法人日本口腔インプラント学会中国・四国支部学術大会, 2011年10月.
259.	栗林伸行, 内田大亮, 玉谷哲也, 永井宏和, 宮本洋二 : stromal-cell derived factor (SDF)-1/CXCR4システムにより誘導される口腔癌における転移関連microRNAの同定, 第70回日本癌学会学術総会, 2011年10月.
260.	藤澤健司, 大江剛, 内田大亮, 永井宏和, 宮本洋二 : ショートインプラントに関する臨床統計学的検討, 第41回日本口腔インプラント学会, Vol.24, No.Specioal Issue, 242, 2011年9月.
261.	小林真左子, 太田正人, 下田麻子, 秋吉一成, 宮本洋二, 井関祥子 : 新規徐放性ナノゲルを用いたFGF18によるBMP2依存的な骨修復能の改良, 第32回日本炎症・再生医学会, 2011年6月.
262.	小林真左子, 太田正人, 下田麻子, 秋吉一成, 宮本洋二, 井関祥子 : 新規徐放性ナノゲルを用いたFGF18によるBMP2依存的な骨修復能の改良, 第32回日本炎症・再生医学会, 2011年6月.
263.	佐藤裕子, 宮内美和, 内田大亮, 髙丸菜都美, 玉谷哲也, 藤澤健司, 永井宏和, 久保典子, 菅原千恵子, 高橋章, 宮本洋二 : 口腔扁平上皮癌の頸部リンパ節転移の診断におけるFDG-PET検査の有用性, 第40回(社)日本口腔外科学会中・四国地方会, 2011年5月.
264.	山本修史, 内田大亮, 栗林伸行, 大江剛, 玉谷哲也, 藤澤健司, 永井宏和, 宮本洋二 : 舌対称性脂肪腫症の1例, 第40回(社)日本口腔外科学会中・四国地方会, 2011年5月.
265.	宮内美和, 宮本洋二 : ビスフォスフォネート関連顎骨壊死に関する最新の知見, 第38回四国歯学会例会, 2011年3月.
266.	藤澤健司, 髙丸菜都美, 工藤景子, 大江剛, 内田大亮, 玉谷哲也, 永井宏和, 宮本洋二 : インプラント治療に関連したと思われるビスフォスフォネート製剤による顎骨壊死の2例, Japanese Journal of Maxillo Facial Implants, Vol.9, No.3, 86, 2010年9月.
267.	髙丸菜都美, 玉谷哲也, 内田大亮, 堀内信也, 永井宏和, 田中栄二, 宮本洋二 : 最近，頭を悩ませた臨床症例その5∼片側性下顎頭過成長を伴う顔面非対称症例の治療経験, 四国歯学会第36回例会, 2010年3月.
268.	内田大亮, 尾上富太郎, 大江剛, 茂木勝美, 玉谷哲也, 東雅之, 永井宏和, 宮本洋二 : 最近，頭を悩ませた臨床症例(その4), 四国歯学会雑誌, Vol.22, No.2, 205, 2010年.
269.	栗林伸行, 佐々井明子, 玉谷哲也, 湯淺哲也, 工藤景子, 藤澤健司, 永井宏和, 宮本洋二 : 当院における角化嚢胞性歯原性腫瘍の臨床的検討, 日本口腔科学会雑誌, Vol.59, No.2, 89, 2010年.
270.	藤岡真左子, 大江剛, 茂木勝美, 内田大亮, 玉谷哲也, 永井宏和, 宮本洋二 : 当科における最近5年間の顎顔面骨骨折の臨床統計的検討, 日本口腔科学会雑誌, Vol.59, No.2, 92, 2010年.
271.	藤澤健司, 湯淺哲也, 大江剛, 永井宏和, 宮本洋二 : 即時荷重インプラントに関する臨床的検討 5年経過時の臨床成績, 日本口腔インプラント学会誌, Vol.23, 184, 2010年.
272.	髙丸菜都美, 玉谷哲也, 永井宏和, 宮本洋二 : 下顎頭の片側性過成長による顔面非対称症例の治療経験, 日本口腔外科学会雑誌, Vol.56, No.Suppl., 151, 2010年.
273.	栗林伸行, 内田大亮, 玉谷哲也, 永井宏和, 宮本洋二 : 頭頸部癌細胞株におけるCD44の癌幹細胞マーカーとしての検証, 日本口腔外科学会雑誌, Vol.56, No.Suppl., 258, 2010年.
274.	髙丸菜都美, 玉谷哲也, 内田大亮, 堀内信也, 永井宏和, 田中栄二, 宮本洋二 : 最近，頭を悩ませた臨床症例(その5) 片側性下顎頭過成長を伴う顔面非対称症例の治療経験, 四国歯学会雑誌, Vol.23, No.2, 142, 2010年.
275.	藤岡真左子, 大江剛, 永井宏和, 内田大亮, 玉谷哲也, 宮本洋二 : 唾液腺癌に対するバルプロ酸の抗腫瘍効果, 日本口腔科学会雑誌, Vol.60, No.1, 126-127, 2010年.
276.	栗林伸行, 内田大亮, 尾上富太郎, 玉谷哲也, 永井宏和, 宮本洋二 : metabotropic glutamate receptor 5阻害剤による口腔扁平上皮癌の転移抑制, 日本口腔科学会雑誌, Vol.60, No.1, 159, 2010年.
277.	玉谷哲也, 髙丸菜都美, 内田大亮, 藤澤健司, 永井宏和, 宮本洋二 : 口腔扁平上皮癌におけるsurvivinの発現に関する検討, 口腔組織培養学会誌, Vol.20, No.1, 59-60, 2010年.
278.	高野栄之, 藤澤健司, 桃田幸弘, 湯淺哲也, 舘原誠晃, 宮本洋二 : 顎裂への骨移植部に対しインプラントによる補綴を行った3症例, 日本口腔インプラント学会誌, Vol.22, No.2, 206, 2009年9月.
279.	舘原誠晃, 宮本洋二, 永井宏和, 藤澤健司, 桃田幸弘, 湯淺哲也, 高野栄之, 福田雅幸 : 低結晶性炭酸アパタイトの顎骨再建への応用に関する基礎的研究骨組織内での長期評価, 日本口腔外科学会雑誌, Vol.55, No.Suppl., 286, 2009年9月.
280.	舘原誠晃, 宮本洋二, 永井宏和, 藤澤健司, 桃田幸弘, 湯淺哲也, 高野栄之, 福田雅幸 : 低結晶性炭酸含有アパタイトの顎骨再建への応用に関する基礎的研究ウサギ大腿骨内での組織学的検討, 日本口腔科学会雑誌, Vol.58, No.4, 223, 2009年9月.
281.	藤澤健司, 湯淺哲也, 舘原誠晃, 桃田幸弘, 高野栄之, 山内英嗣, 宮本洋二 : 粗面インプラントのオッセオインテグレーション喪失症例の検討, 日本口腔インプラント学会誌, Vol.22, 191, 2009年8月.
282.	高野栄之, 桃田幸弘, 湯淺哲也, 舘原誠晃, 藤澤健司, 宮本洋二 : 低結晶性炭酸含有アパタイトの顎骨再建への応用に関する基礎的研究ウサギ上顎洞内での組織学的検討, 日本口腔インプラント学会誌, Vol.22, 261, 2009年8月.
283.	松田りえ, 堀内信也, 川上恵実, 森博子, 宮本洋二, 田中栄二 : 上顎縦骨折による咬合不全に対し，急速拡大装置を逆回転することで整復した1症例, 第52回中・四国矯正歯科学会学術大会, 2009年7月.
284.	佐々井明子, 大江剛, 内田大亮, 尾上富太郎, 茂木勝美, 玉谷哲也, 東雅之, 永井宏和, 宮本洋二 : 口腔癌由来液性因子がOK-432による末梢血単核球のIFN-γ産生に与える影響, 日本口腔腫瘍学会誌, Vol.21, No.4, 342-343, 2009年.
285.	藤澤健司, 武知正晃, 山内英嗣, 安陪晋, 大塩恭仁, 宮本洋二, 河野文昭, 長山勝 : 共鳴振動数分析装置を用いたインプラント安定性の評価2一即時荷重インプラントにおけるImplant Stability Quotientの経時的変化-, 日本口腔インプラント学会誌, Vol.20, No.1, 123-124, 2007年3月.
286.	南口知穂, 武知正晃, 湯淺哲也, 桃田幸弘, 舘原誠晃, 高野栄之, 石川邦夫, 宮本洋二, 長山勝 : 低結晶性炭酸アパタイト含有PLGA複合体が多核巨細胞に与える影響, 第60回日本口腔科学会総会, 2007年1月. (要約) 1
287.	桃田幸弘, 宮本洋二, 石川邦夫, 武知正晃, 湯淺哲也, 舘原誠晃, 高野栄之, 南口知穂, 長山勝 : HAP Putty(骨止血剤)が血小板凝集および血小板由来増殖因子の分泌に及ぼす影響．, 第60回日本口腔科学会総会, 2007年1月. (要約) 1
288.	舘原誠晃, 武知正晃, 桃田幸弘, 湯淺哲也, 高野栄之, 宮本洋二, 長山勝 : bFGF合浸Hap-PLGA複合体における骨組織反応について, 第50回(社)日本口腔外科学会総会, 2005年9月. (要約) 1
289.	南口知穂, 武知正晃, 湯淺哲也, 桃田幸弘, 舘原誠晃, 高野栄之, 宮本洋二, 里村一人, 長山勝 : 骨組織再生におけるHAP-PLGA複合体の有用性に関する基礎研究, 第59回日本口腔科学会総会, 2005年9月. (要約) 1
290.	桃田幸弘, 宮本洋二, 石川邦夫, 武知正晃, 湯淺哲也, 舘原誠晃, 高野栄之, 南口知穂, 長山勝 : 骨止血剤(HAP putty)による血小板凝集能の亢進, 口腔顎顔面外傷, Vol.4, No.1, 24-25, 2005年6月.
291.	高野栄之, 宮本洋二, 藤澤健司, 湯淺哲也, 桃田幸弘, 長山勝 : 歯科インプラントのオッセオインテグレーション喪失に関する臨床統計学的検討, 第32回日本口腔外科学会中国四国地方部会, 2004年1月. (要約) 1
292.	山之内浩司, 宮本洋二, 桃田幸弘, 久米景子, 鎌田伸之 : 舌体深部へのボディーピアス迷入の1例, 第31回日本口腔外科学会中・四国地方会, 2002年6月. (要約) 1
293.	藤澤健司, 宮本洋二, 舘原誠晃, 武知正晃, 桃田幸弘, 湯淺哲也, 長山勝, 大倉一夫, 山内英嗣, 郡元治, 松浦広輿, 坂東永一, 池田隆志 : 眼窩エピテーゼの維持源にオッセオインテグレーティツドインプラントを応用した1例, 第21回日本口腔インプラント学会中国・四国支部総会・学術大会, 2001年. (要約) 1
294.	宮本洋二, 藤澤健司, 湯淺哲也, 桃田幸弘, 武知正晃, 長山勝, 山内英嗣, 坂東永一, 日野出大輔 : 下顎無歯顎インプラント患者のオトガイ孔後方へのfixture埋入は是か非か?, 第31回日本口腔インプラント学会総会・学術大会, 2001年. (要約) 1
295.	舘原誠晃, 宮本洋二, 藤澤健司, 武知正晃, 桃田幸弘, 湯淺哲也, 増田尚子, 長山勝 : インプラント型仮骨延長器による垂直的歯槽骨延長の経験, 第46回(社)日本口腔外科学会総会, 2001年. (要約) 1
296.	藤澤健司, 宮本洋二, 武知正晃, 桃田幸弘, 湯淺哲也, 藤武智, 増田尚子, 舘原誠晃, 長山勝 : ブローネマルクインプラントの臨床統計学的検討一上部構造装着後のフイクスチャー除去症例について-, 第55回日本口腔科学会総会, 2001年. (要約) 1
297.	舘原誠晃, 宮本洋二, 藤澤健司, 武知正晃, 桃田幸弘, 湯淺哲也, 藤武智, 飛梅悟, 増田尚子, 長山勝, 郡元治, 松浦広輿, 山内英嗣, 大倉一夫, 日野出大輔 : 当科におけるブローネマルクインプラントの臨床統計的検討-Osseointegration獲得に関与する因子について-, 第20回日本口腔インプラント学会中国・四国支部総会・学術大会, 2000年. (要約) 1
298.	合田大亮, 藤澤健司, 宮本洋二, 武知正晃, 林英司, 長山勝 : PLLA(ポリ-L-乳酸)メッシュトレイおよび新鮮自家腸骨海綿骨細片移植による下顎再建後にインプラントを応用した1例, 第20回日本口腔インプラント学会中国・四国支部総会・学術大会, 2000年. (要約) 1
299.	宮本洋二, 武知正晃, 桃田幸弘, 湯淺哲也, 藤武智, 長山勝, 今政幸 : カルシウム溶液処理によるチタン表面の改質と疑似体液中における挙動, 第45回日本口腔外科学会総会, 2000年. (要約) 1
300.	藤武智, 宮本洋二, 武知正晃, 桃田幸弘, 湯淺哲也, 長山勝, 石川邦夫, 鈴木一臣 : 炭酸水素ナトリウムを用いた骨置換型アパタイトセメントー培養破骨細胞による吸収性の評価-, 第45回日本口腔外科学会総会, 2000年. (要約) 1
301.	武知正晃, 宮本洋二, 藤澤健司, 桃田幸弘, 湯淺哲也, 藤武智, 長山勝, 鈴木温, 日野出大輔 : 当科におけるインプラント失敗例に関する臨床的検討一上部構造装着前の失敗症例について一, 第30回日本口腔インプラント学会総会・学術大会, 2000年. (要約) 1
302.	宮本洋二, 武知正晃, 桃田幸弘, 湯淺哲也, 藤武智, 長山勝 : 急速アパタイト転換型リン酸カルシウムセメントの開発, 第30回日本口腔インプラント学会総会・学術大会, 2000年. (要約) 1
303.	山之内浩司, 里村一人, 藤澤健司, 宮本洋二, 長山勝, 中村克彦 : 確定診断に至らなかった難治性口内炎の1例, 第10回日本口腔粘膜学会総会, 2000年. (要約) 1

作品:

1.	石川邦夫, 宮本洋二 : インプラント治療用人工骨「ジーシーサイトランスグラニュール®」の開発と臨床応用. Ⅰ.驚異の炭酸アパタイト人工骨補填材, Dental Diamond, Vol.43, No.9, 142-146, 2018年9月.
2.	石川邦夫, 宮本洋二 : インプラント治療用人工骨「ジーシーサイトランスグラニュール®」の開発と臨床応用. Ⅱ. サイトランスグラニュール®の開発と臨床応用, Dental Diamond, Vol.49, No.3, 147-151, 2018年8月.
3.	石川邦夫, 宮本洋二, 春日井昇平, 古谷野潔 : 日本で初めてインプラントの併用が認可された骨補填材:サイトランス® グラニュールとは?, Quintessence DENTAL Implantology, Vol.25, No.4, 631-633, 2018年7月.

その他・研究会:

1.	宮本洋二 : 新規骨補填材としての炭酸アパタイトの開発．-サイトランスグラニュール-, 結志会, 2019年2月.
2.	宮本洋二 : 私の行っている大胸筋皮弁, 第6回岡山大学臨床解剖口腔外科手術手技研修会, 2019年2月.
3.	宮本洋二 : 気管切開術, 第6回岡山大学臨床解剖口腔外科手術手技研修会, 2019年2月.
4.	尾上真奈美, 高石和美, 工藤景子, 髙丸菜都美, 鎌田久美子, 大塚良, 藤原茂樹, 江口覚, 宮本洋二, 北畑洋 : 根管治療後に下歯槽神経感覚障害が生じた1例, 第32回中国·四国歯科麻酔研究会, 2017年7月.
5.	宮本洋二 : 口腔がん検診とは-全国の実施状況と徳島の現状-, 平成23年度徳島県歯科医師会四国歯学会合同シンポジウム「徳島県における口腔がん検診に向けて-わが国の口腔がん検診の現状-」, 2011年9月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

骨補填材兼GBR用スペーサー機能をもつ炭酸アパタイト／魚コラーゲンシートの開発 (研究課題/領域番号: 23K09372 )
遺伝的多様性に基づいた新規口腔がん特異的分子標的の探索 (研究課題/領域番号: 23K24546 )
唾液腺幹/前駆細胞の維持・再生に関わる遺伝子の同定と新たな口腔乾燥症治療への応用 (研究課題/領域番号: 22K10121 )
Lubricinによる変形性顎関節症に対する新規治療法の開発 (研究課題/領域番号: 21K10096 )
感染制御と骨再生を同時に可能とするハイブリッド型骨補填材による顎骨骨髄炎治療戦略 (研究課題/領域番号: 21K10095 )
カーボネイトアパタイトの高い骨伝導能・骨再生能を細胞の分子メカニズムから解明する (研究課題/領域番号: 21H03139 )
多孔質炭酸アパタイト・魚コラーゲン複合体をスキャフォールドとした戦略的骨再生治療 (研究課題/領域番号: 20K10180 )
頸部リンパ節転移の超早期検出への挑戦－転移可視化モデルの樹立と超音波診断法の構築 (研究課題/領域番号: 20K10140 )
一方向連通気孔を持つ炭酸アパタイトによる顎骨再建と骨再生医療への応用 (研究課題/領域番号: 19K10333 )
ハイドロキシアパタイトの優れた骨伝導能とバイオインテグレーションの本質を解明する (研究課題/領域番号: 19K10290 )
放射線性顎骨壊死モデルの確立とスタチンの血管新生・骨形成作用による予防・治療戦略 (研究課題/領域番号: 19K10268 )
初期化と遺伝子変異の導入によるヒト口腔癌を模倣した新規癌幹細胞モデルの確立 (研究課題/領域番号: 19H03853 )
スポンジ状の弾性を有する新規炭酸アパタイト骨補填材の開発 (研究課題/領域番号: 18K09815 )
3種類のサンプリングによるアレイ解析を用いた口腔癌のセツキシマブ耐性化機構の解明 (研究課題/領域番号: 18K09792 )
変形性顎関節症の新規治療法の開発を目指したLubricinの発現調節機構の解明 (研究課題/領域番号: 18K09769 )
スタチンの血管新生作用と骨形成作用による薬剤関連顎骨壊死の予防・治療法の開発 (研究課題/領域番号: 18K09746 )
癌幹細胞と口腔癌転移患者血液の２つに着目した転移特異的miRNA同定と診断法確立 (研究課題/領域番号: 18K09745 )
骨置換性炭酸アパタイト多孔体と栄養血管を利用した皮膚と骨の複合的再生療法の開発 (研究課題/領域番号: 18H03002 )
硫酸カルシウムから作製した多孔質炭酸アパタイトと骨髄幹細胞による骨再生医療の開発 (研究課題/領域番号: 16K11752 )
発生期の上皮間葉相互作用を再現したiPS細胞の分化誘導法と唾液腺再生医療の開発 (研究課題/領域番号: 16K11751 )
口腔癌顎骨浸潤モデルの確立と、顎骨浸潤評価を目的としたＣＴ検査の開発 (研究課題/領域番号: 16K11505 )
染色体パッセンジャー複合体タンパクの分解とその破綻による口腔発癌機構の解明と制御 (研究課題/領域番号: 16H05542 )
オッセオインテグレーションとバイオインテグレーションの本質を細胞サイドから探る (研究課題/領域番号: 15K15741 )
iPS細胞と低結晶性炭酸アパタイトを用いたハイブリッド型人工骨による骨再生医療 (研究課題/領域番号: 15K11315 )
口腔癌頸部リンパ節転移のバイオマーカーとしての血液中microRNAの探索 (研究課題/領域番号: 15K11294 )
創傷治癒不全および難治性口内炎に対する新規治癒促進剤としてのレプチンの挑戦 (研究課題/領域番号: 15K11253 )
CXCR4システムを介した口腔癌の転移機構におけるmiR-518c-5pの役割 (研究課題/領域番号: 26463046 )
口腔癌根治を目指した放射線治療の挑戦―分子標的薬と抗癌剤の最適な併用法の追究― (研究課題/領域番号: 26462838 )
骨の微小環境を利用したスキャフォールドによるiPS細胞の骨芽細胞への分化誘導促進 (研究課題/領域番号: 25670859 )
ゼラチン複合型炭酸アパタイトフォームの創製と顎骨再生への応用 (研究課題/領域番号: 25463137 )
新規培養法CTOSを用いた口腔癌に対する抗癌剤感受性試験の開発と耐性機構の解明 (研究課題/領域番号: 25463110 )
NF-κBとCXCR4関連miRNAを標的とした口腔癌に対する複合的治療法の開発 (研究課題/領域番号: 25293411 )
ポリＡＤＰーリボース合成酵素（ＰＡＲＰ）を分子標的とした口腔癌の新規治療法の開発 (研究課題/領域番号: 24593036 )
不死化歯原性細胞との相互作用を利用した人工多能性幹（ｉＰＳ）細胞による歯再生医療 (研究課題/領域番号: 24592989 )
ＳＤＦー１／ＣＸＣＲ４システムを介した口腔癌の転移機構におけるｍｉＲＮＡの役割 (研究課題/領域番号: 23592964 )
炭酸アパタイト骨置換材の多孔性制御による骨置換速度の飛躍的増進 (研究課題/領域番号: 23390444 )
人工多能性幹(iPS)細胞の間葉系幹細胞を経由した骨芽細胞への分化誘導法の確立 (研究課題/領域番号: 22659370 )
多孔性リン酸カルシウムセメントへのアプローチ (研究課題/領域番号: 22659358 )
骨置換性炭酸アパタイトの既成スペーサーを用いた骨移植を必要としないサイナスリフト (研究課題/領域番号: 22592260 )
抗アポトーシス蛋白とNF-kBを分子標的とした口腔癌の新規治療法の開発 (研究課題/領域番号: 21592556 )
歯の発生過程における上皮-間葉相互作用の分子メカニズムを応用した歯再生医療の開発 (研究課題/領域番号: 21592528 )
ビスホスホネートによる顎骨壊死の予測マーカーならびに発症メカニズムに関する検討 (研究課題/領域番号: 21592386 )
海綿骨型骨置換材の創製 (研究課題/領域番号: 20390500 )
ケイ酸カルシウム処理による骨伝導性制御 (研究課題/領域番号: 19659510 )
脂肪組織から分離した間葉系幹細胞と低結晶性炭酸アパタイトを用いた歯再生医療の開発 (研究課題/領域番号: 19592282 )
リンパ管造影CTを用いたセンチネルリンパ節同定法の口腔癌への応用と有用性の検討 (研究課題/領域番号: 19592281 )
不死化歯由来細胞株と生体内吸収性材料を用いた歯の再生医療用スキャフォールドの開発 (研究課題/領域番号: 18659588 )
柔軟性を示す骨置換材の創製 (研究課題/領域番号: 18659578 )
機械的圧縮ストレスがヒト顎関節滑膜細胞へ及ぼす骨代謝作用における分子生物学的解析 (研究課題/領域番号: 18592196 )
骨置換性カーボネイトアパタイトによる顎骨再建と骨再生用スキャフォールドへの応用 (研究課題/領域番号: 18390533 )
破骨細胞吸収型骨置換材の創製 (研究課題/領域番号: 18390517 )
歯胚より樹立した歯の前駆細胞を用いた歯再生のための細胞導入治療法の開発 (研究課題/領域番号: 18300159 )
海綿骨の形態と組成を模倣した完全連通型骨置換材の創製 (研究課題/領域番号: 17659612 )
ヒト顎関節滑膜細胞株を用いたストレスシグナル伝達経路の解析と遺伝子治療への応用 (研究課題/領域番号: 17592065 )
テーラーメイド医療を目指した傾斜機能型骨置換材に関する研究 (研究課題/領域番号: 16659537 )
骨・軟骨再生医療用の吸収性多孔質高分子ポリマーの作製と血管柄付き移植による骨再建 (研究課題/領域番号: 16592003 )
顎関節造影MRIと滑液・滑膜分析を用いた顎関節内障の病態解明に関する研究 (研究課題/領域番号: 16591981 )
骨成長端組成から学ぶ高骨形成能骨置換材の創製 (研究課題/領域番号: 16390559 )
生体吸収性のガラス繊維とポリマーの複合による硬組織再生支援FRPの開発 (研究課題/領域番号: 15592053 )
アパタイトプレフォームの創製に関する研究 (研究課題/領域番号: 14657505 )
ヒト末分化間葉系幹細胞から骨芽細胞への分化過程における遺伝子発現に関する研究 (研究課題/領域番号: 14571938 )
骨模倣型アパタイトセメントによる骨置換速度の増進 (研究課題/領域番号: 14571897 )
骨髄間質および末梢循環血中に在存する体性幹細胞の分離とその再生医療への応用 (研究課題/領域番号: 14571895 )
骨再生医療用の吸収性多孔体バイオセラミックスの作製と血管柄付き移植による骨再建 (研究課題/領域番号: 14571894 )
リン酸カルシウム系材料の疑似体液浸漬による骨伝導能評価法の確立 (研究課題/領域番号: 13672040 )
組織再生を目的とした自己硬化型細胞制御膜に関する研究 (研究課題/領域番号: 13470415 )
三次元骨梁構造セラミックスフォームの試作と骨内組織反応 (研究課題/領域番号: 12877315 )
連続気孔形成によるアパタイトセメントの骨置換速度の増進 (研究課題/領域番号: 11671992 )
骨置換型の炭酸含有アパタイトセメントの試作とその組織学的検討 (研究課題/領域番号: 10671885 )
骨置換型アパタイトセメントへのアプローチ (研究課題/領域番号: 09470438 )
骨置換性リン酸カルシウム・コーティング・チタンインプラントの試作と骨内反応 (研究課題/領域番号: 07857144 )
酸処理法による傾斜機能バイオセラミックスの試作について (研究課題/領域番号: 07672115 )
非崩壊型アパタイトセメントの顎骨再建への応用 (研究課題/領域番号: 07557280 )
迅速硬化型アパタイトセメントの生体親和性に関する検討 (研究課題/領域番号: 07557274 )
ラット可移植性口腔癌細胞の単クローン抗体作製と免疫電顕法による癌細胞動態の研究 (研究課題/領域番号: 06771920 )
傾斜機能バイオセラミックス多孔体の試作と生体内反応 (研究課題/領域番号: 06671955 )
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名誉教授 : 宮本洋二

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名誉教授 : 宮本 洋二

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名誉教授 : 宮本洋二