徳島大学 / 教育研究者総覧 --- 東雅之

個人のホームページ

https://researchmap.jp/read0088392 (researchmap)

専門分野

○	歯学 (Dentistry)

研究テーマ

○

著書・論文

著書:

1.	千葉俊美, 山田浩之, 東雅之, 青田桂子 : 歯科医師のための内科学, 2021年3月.
2.	青田桂子, 東雅之 : 口腔外科学第4版, --- 局所麻酔 ---, 医歯薬出版株式会社, 東京, 2020年2月.
3.	青田桂子, 東雅之 : 悪性腫瘍治療時の口腔ケア, 医歯薬出版株式会社, 2014年5月.
4.	山村佳子, 東雅之 : 口腔真菌症, 医歯薬出版株式会社, 2014年5月.
5.	松本文博, 茂木勝美, 高野栄之, 可児耕一, 東雅之 : 口腔顎顔面に現れる全身性疾患, 医歯薬出版株式会社, 2014年5月.
6.	松本文博, 茂木勝美, 高野栄之, 可児耕一, 東雅之 : 口腔顎顔面に現れる全身性疾患, 医歯薬出版株式会社, 東京, 2014年5月.

学術論文(審査論文):

1.	Fumiya Kano, Noboru Hashimoto, Yao Liu, Linze Xia, Takaaki Nishihara, Wakana Oki, Keita Kawarabayashi, Noriko Mizusawa, Keiko Aota, Takayoshi Sakai, Masayuki Azuma, Hideharu Hibi, Tomonori Iwasaki, Tsutomu Iwamoto, Nobuyasu Horimai and Akihito Yamamoto : Therapeutic benefits of factors derived from stem cells from human exfoliated deciduous teeth for radiation-induced mouse xerostomia, Scientific Reports, Vol.13, No.1, 2706-2719, 2023. (要約) Radiation therapy for head and neck cancers is frequently associated with adverse effects on the surrounding normal tissue. Irreversible damage to radiation-sensitive acinar cells in the salivary gland (SG) causes severe radiation-induced xerostomia (RIX). Currently, there are no effective drugs for treating RIX. We investigated the efficacy of treatment with conditioned medium derived from stem cells from human exfoliated deciduous teeth (SHED-CM) in a mouse RIX model. Intravenous administration of SHED-CM, but not fibroblast-CM (Fibro-CM), prevented radiation-induced cutaneous ulcer formation (p < 0.0001) and maintained SG function (p < 0.0001). SHED-CM treatment enhanced the expression of multiple antioxidant genes in mouse RIX and human acinar cells and strongly suppressed radiation-induced oxidative stress. The therapeutic effects of SHED-CM were abolished by the superoxide dismutase inhibitor diethyldithiocarbamate (p < 0.0001). Notably, quantitative liquid chromatography-tandem mass spectrometry shotgun proteomics of SHED-CM and Fibro-CM identified eight proteins activating the endogenous antioxidant system, which were more abundant in SHED-CM than in Fibro-CM (p < 0.0001). Neutralizing antibodies against those activators reduced antioxidant activity of SHED-CM (anti-PDGF-D; p = 0.0001, anti-HGF; p = 0.003). Our results suggest that SHED-CM may provide substantial therapeutic benefits for RIX primarily through the activation of multiple antioxidant enzyme genes in the target tissue. (キーワード) Mice / Humans / Animals / Antioxidants / Stem Cells / Disease Models, Animal / Xerostomia / Tooth, Deciduous (徳島大学機関リポジトリ) ● Metadata: 118051 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-023-29176-w (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36792628 ● Summary page in Scopus @ Elsevier: 2-s2.0-85148115146 (徳島大学機関リポジトリ: 118051, DOI: 10.1038/s41598-023-29176-w, PubMed: 36792628, Elsevier: Scopus)
2.	桃田幸弘, 高野栄之, 可児耕一, 小野信二, 東雅之 : 漢方薬が奏効した特発性first bite syndromeの1例, 痛みと漢方, Vol.32, 1-5, 2023年.
3.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Shinji Ono and Masayuki Azuma : Idiopathic First Bite Syndrome Well-Treated with the Japanese Herbal Medicine Kakkonto: Analysis of Heart Rate Variability., Oral Science in Japan, Vol.2021, 31-32, 2021.
4.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Shinji Ono, Yukihiro Momota and Masayuki Azuma : Inhibition of JAK-STAT Signaling by Baricitinib Reduces Interferon-γ-Induced CXCL10 Production in Human Salivary Gland Ductal Cells., Inflammation, Vol.44, No.1, 206-216, 2021. (徳島大学機関リポジトリ) ● Metadata: 116171 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10753-020-01322-w (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32772240 ● Search Scopus @ Elsevier (PMID): 32772240 ● Search Scopus @ Elsevier (DOI): 10.1007/s10753-020-01322-w (徳島大学機関リポジトリ: 116171, DOI: 10.1007/s10753-020-01322-w, PubMed: 32772240)
5.	青田桂子, 山ノ井朋子, 可児耕一, 東雅之 : シェーグレン症候群の病態形成におけるCXCL10の役割, 口腔組織培養学会誌, Vol.29, No.2, 39-47, 2020年. (要約) Sjögren's syndrome (SS) is a common autoimmune disease characterized by the destruction of acinar structure by marked lymphocytic infiltrates in the salivary and lacrimal glands, resulting in sicca symptoms. Gene expression profiling of lip salivary glands (LSGs) shows that C-X-C motif chemokine 10 (CXCL10) expression is upregulated in patients with primary SS (pSS). CXCL10 and its receptor, C-X-C receptor 3 (CXCR3), contribute to the pathogenesis of SS. We investigated the clinical significance of CXCL10 and CXCR3 in the autoimmune lesions of pSS and the molecular mechanisms of CXCL10 upregulation in the salivary gland cells. CXCL10 showed particularly intense staining in LSG ductal cells from pSS patients. CXCR3 expression was detected primarily in CD163+ macrophages. The number of CXCR3+CD163+ macrophages was inversely correlated with the severity of LSG inflammatory lesions. Our in vitro experiments demonstrated that human salivary gland ductal (NS-SV-DC) cells produced higher levels of CXCL10 than acinar (NS-SV-AC) cells. Furthermore, NS-SV-DC and NS-SV-AC cells had different regulators of CXCL10 enhancement: interferon (IFN)-γ had more potential than IFN-α, tumor necrosis factor (TNF)-α, and interleukin (IL)1-β in the induction of CXCL10 production in NS-SV-DC cells, whereas TNF-α had the potential to induce CXCL10 production in NS-SV-AC cells. Our results suggest that CXCL10 overexpression in salivary glands is mainly caused by IFN-γ-stimulated salivary gland ductal cells. The enhanced production of CXCL10 by ductal cell IFN-γ results in the migration of CXCR3+ immune cells. CXCL10 plays an important role in SS pathogenesis, and CXCL10 regulation may be useful in the treatment of SS patients. (キーワード) Sjögren's syndrome / シェーグレン症候群 / C-X-C motif chemokine 10 / CXCL10 / interferon-gamma / IFN-γ (徳島大学機関リポジトリ) ● Metadata: 116159 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050852252685076224 (徳島大学機関リポジトリ: 116159, CiNii: 1050852252685076224)
6.	Yuriko Goto, Miho Ibi, Hirotaka Sato, Junichi Tanaka, Rika Yasuhara, Keiko Aota, Masayuki Azuma, Toshiyuki Fukada, Kenji Mishima and Tarou Irie : PLAG1 enhances the stemness profiles of acinar cells in normal human salivary glands in a cell type-specific manner., Journal of Oral Biosciences, Vol.62, No.1, 99-106, 2020. (要約) Details of the histogenesis of salivary gland tumors are largely unknown. The oncogenic role of PLAG1 in the salivary gland has been demonstrated in vivo. Herein, we demonstrate PLAG1 roles in the acinar and ductal cells of normal human salivary glands to clarify the early events that occur during the histogenesis of salivary gland tumors. Normal salivary gland cells with acinar and ductal phenotypes were transfected with PLAG1 plasmid DNA. Subsequently, PLAG1 overexpressed and mock cells were examined by cell proliferation, transwell migration, and salisphere formation assays. Differentiation and salivary and pluripotent stem cell marker expression levels were evaluated by quantitative reverse transcription-polymerase chain reaction and immunofluorescence. Alterations in transcriptional expressions were investigated via cap analysis of gene expression with gene-enrichment and functional annotation analysis. PLAG1 promoted cell proliferation and transwell migration in the acinar and ductal cells, and markedly enhanced the stemness profiles and luminal cell-like profiles in acinar cells; the stemness profiles were partially increased in the ductal cells. PLAG1 enhanced the stemness profiles in the acinar cells of normal human salivary glands in a cell type-specific manner. Thus, it may be involved in salivary gland tumorigenesis by increasing the stemness character of the normal salivary gland cells. (徳島大学機関リポジトリ) ● Metadata: 115184 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.job.2020.01.002 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32007659 ● Summary page in Scopus @ Elsevier: 2-s2.0-85079425125 (徳島大学機関リポジトリ: 115184, DOI: 10.1016/j.job.2020.01.002, PubMed: 32007659, Elsevier: Scopus)
7.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二, 東雅之 : 三剤併用が奏効した一次性舌痛症の3例, 日本口腔顔面痛学会雑誌, Vol.11, No.1, 21-27, 2019年. (要約) 一次性舌痛症は舌に痛みなどの異常感を訴えるものの，器質的または精神的要因のいずれも見出せないものとされる．近年，本症と神経障害性疼痛との関連が論じられている．今般，われわれはプレガバリン，トラマドール塩酸塩/アセトアミノフェン配合錠および加工附子末製剤の三剤併用が奏効した本症の3例を経験したので，その概要を報告する．患者は男性2名，女性1名，年齢42∼79歳(平均54.3歳)であった．全例に対してこれら三剤を併用した．痛みは緩解し，健康関連QOLも向上した．特記すべき有害事象は認められなかった．本症に対するこれら三剤併用の有用性が示唆された． (キーワード) 一次性舌痛症 / プレガバリン / トラマドール塩酸塩 / アセトアミノフェン / 加工附子末製剤 (出版サイトへのリンク) ● Publication site (DOI): 10.11264/jjop.11.21 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390846609775857792 ● Search Scopus @ Elsevier (DOI): 10.11264/jjop.11.21 (DOI: 10.11264/jjop.11.21, CiNii: 1390846609775857792)
8.	Keiko Aota, Shinji Ono, Tomoko Yamanoi, Kohichi Kani, Yukihiro Momota and Masayuki Azuma : MMP-9 inhibition suppresses interferon-γ-induced CXCL10 production in human salivary gland ductal cells., Inflammation, Vol.42, No.6, 2148-2158, 2019. (要約) Gene expression profiling of lip salivary gland (LSG) has shown that C-X-C motif chemokine 10 (CXCL10) and matrix metalloproteinase 9 (MMP9) expression is upregulated in primary Sjögren's syndrome (pSS) patients. Although CXCL10 and MMP-9 are both associated with pSS pathogenesis, the potential relationship between these two factors has not been investigated. In this study, we used LSG sections from pSS patients and human salivary gland cell lines to investigate the relationship between CXCL10 and MMP-9. Immunofluorescence analyses revealed that CXCL10 and MMP-9 were co-expressed in the LSG of pSS patients, particularly in expanded ductal cells. Furthermore, RT-qPCR analyses on human salivary gland ductal NS-SV-DC cells confirmed that CXCL10 expression was induced by interferon (IFN)-γ, whereas that of MMP9 was stimulated by IFN-α, tumor necrosis factor-α, and interleukin-1β. Remarkably, MMP-9 inhibition in IFN-γ-stimulated NS-SV-DC cells significantly decreased CXCL10 mRNA and secreted protein levels. Further analyses established that MMP-9 inhibition in IFN-γ-stimulated NS-SV-DC cells decreased STAT1 phosphorylation and hence suppressed IFN-γ signaling. Collectively, these results suggest that in addition to its reported role in the destruction of acinar structures, MMP-9 is involved in the IFN-γ-induced production of CXCL10 in pSS lesions. We believe that our findings open the door to the development of novel treatments for pSS, based on the modulation of MMP-9 activity. (キーワード) Cell Line / Cells, Cultured / Chemokine CXCL10 / Humans / Interferon-gamma / Matrix Metalloproteinase 9 / Phosphorylation / STAT1 Transcription Factor / Salivary Ducts / Salivary Glands / Sjogren's Syndrome (徳島大学機関リポジトリ) ● Metadata: 115182 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10753-019-01079-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31440939 ● Summary page in Scopus @ Elsevier: 2-s2.0-85070939843 (徳島大学機関リポジトリ: 115182, DOI: 10.1007/s10753-019-01079-x, PubMed: 31440939, Elsevier: Scopus)
9.	Keiko Aota, Kohichi Kani, Tomoko Yamanoi, Yukihiro Momota, Masami Ninomiya, Hiromichi Yumoto and Masayuki Azuma : Management of tooth extraction in a patient with ELANE gene mutation-induced cyclic neutropenia: A case report., Medicine, Vol.98, No.39, e17372, 2019. (要約) Cyclic neutropenia (CyN) is a rare hematological disease, and patients with CyN often experience an early onset of severe periodontitis and are forced to undergo tooth extraction. Here, we report a case of a patient with CyN who showed different periodicity and oscillations of neutrophil count compared with her mother, despite sharing the same novel genetic mutation. A 17-year-old Japanese girl who had been diagnosed with CyN shortly after birth presented to our hospital with a complaint of mobility of her teeth and gingivitis. Upon presentation, an intraoral examination was performed and revealed redness and swelling of the marginal and attached gingiva. Radiographs revealed extreme resorption of the alveolar bone and apical lesions in her mandibular lateral incisors. The patient's hematologic data demonstrated a lack of blood neutrophils (0/μL). The patient had no history of dental extraction, and her mother also had a history of CyN. The patient was diagnosed with severe periodontitis that was associated with CyN. Gene testing showed a novel heterozygous mutation in exon 4 of the ELANE gene (c.538delC, p.Leu180Ser fsX11). Based on the clinical findings, we planned to extract the patient's mandibular lateral incisors. Although the tooth extraction was scheduled considering the cyclic variation in neutrophil count, the patient's neutrophil count was 0/μL on the day before the planned extraction. Therefore, granulocyte-colony stimulating factor (G-CSF) was administered to increase the patient's neutrophil count. On the day of the patient's admission for the tooth extraction, she presented with fever (body temperature, 38.5°C), tonsillitis, and stomatitis. The extraction was subsequently delayed, and the patient was administered antibiotics and G-CSF for 4 days. At this time, the neutrophil count increased to 750/μL, and the tooth extraction was carried out safely. The postoperative course was uneventful, and the healing process at the extraction site was excellent. There is a possibility that the periodicity and oscillations of neutrophil count may change with growth in patients with CyN. Therefore, it is important to frequently examine and treat patients with fluctuating neutrophil levels for the management of invasive dental treatment in patients with CyN. (キーワード) Adolescent / Exons / 女性 (female) / Humans / Leukocyte Count / Leukocyte Elastase / Mutation / Neutropenia / Neutrophils / 歯周病 (periodontitis) / Tooth Extraction (徳島大学機関リポジトリ) ● Metadata: 115183 (出版サイトへのリンク) ● Publication site (DOI): 10.1097/MD.0000000000017372 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31574885 ● Summary page in Scopus @ Elsevier: 2-s2.0-85072847226 (徳島大学機関リポジトリ: 115183, DOI: 10.1097/MD.0000000000017372, PubMed: 31574885, Elsevier: Scopus)
10.	Yukihiro Momota, Hideyuki Takano and Masayuki Azuma : Effectiveness of Kampo Medicines against Intractable Stomatitis: A Mini-Review, International Journal of Medical and Dental Sciences, Vol.8, No.2, 1709-1714, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.18311/ijmds/2019/22935 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.18311/ijmds/2019/22935 (DOI: 10.18311/ijmds/2019/22935)
11.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Shinji Ono and Masayuki Azuma : Oral Lichen Planus Well-Treated with Kampo Medicines: Two Case Reports, IOSR Journal of Dental and Medical Sciences, Vol.18, No.2, 68-72, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.9790/0853-1802046872 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-1802046872 (DOI: 10.9790/0853-1802046872)
12.	Yukihiro Momota, Nao Masuda, Hideyuki Takano and Masayuki Azuma : A Case of Well-Managed Sarcoidosis with Cardiac Autonomic Dysfunction during Dental Therapy: Significance of Heart Rate Variability Analysis., IOSR Journal of Dental and Medical Sciences, Vol.18, No.1, 27-29, 2019. (出版サイトへのリンク) ● Publication site (DOI): 10.9790/0853-1801072729 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-1801072729 (DOI: 10.9790/0853-1801072729)
13.	Yukihiro Momota, Keiko Aota, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : Concomitant Pregabalin and Tramadol Hydrochloride/Acetaminophen Formulation Relieved Neuropathic Itch of Gingiva: A Case Report., IOSR Journal of Dental and Medical Sciences, Vol.17, No.12, 68-71, 2018. (出版サイトへのリンク) ● Publication site (DOI): 10.9790/0853-1712036871 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-1712036871 (DOI: 10.9790/0853-1712036871)
14.	Aya Ushio, Rieko Arakaki, Kunihiro Ohtsuka, Akiko Yamada, Takaaki Tsunematsu, Yasusei Kudo, Keiko Aota, Masayuki Azuma and Naozumi Ishimaru : CCL22-Producing Resident Macrophages Enhance T Cell Response in Sjögren's Syndrome., Frontiers in Immunology, Vol.9, 2594, 2018. (要約) Macrophages (MΦs) are critical regulators of immune response and serve as a link between innate and acquired immunity. The precise mechanism of involvement of tissue-resident MΦs in the pathogenesis of autoimmune diseases is not clear. Here, using a murine model for Sjögren's syndrome (SS), we investigated the role of tissue-resident MΦs in the onset and development of autoimmunity. Two unique populations of CD11b and CD11b resident MΦs were observed in the target tissue of the SS model. Comprehensive gene expression analysis of chemokines revealed effective production of CCL22 by the CD11b MΦs. CCL22 upregulated the migratory activity of CD4 T cells by increasing CCR4, a receptor of CCL22, on T cells in the SS model. In addition, CCL22 enhanced IFN-γ production of T cells of the SS model, thereby suggesting that CCL22 may impair the local immune tolerance in the target organ of the SS model. Moreover, administration of anti-CCL22 antibody suppressed autoimmune lesions in the SS model. Finally, histopathological analysis revealed numerous CCL22-producing MΦs in the minor salivary gland tissue specimens of the SS patients. CCL22-producing tissue-resident MΦs may control autoimmune lesions by enhancing T cell response in the SS model. These results suggest that specific chemokines and their receptors may serve as novel therapeutic or diagnostic targets for SS. (徳島大学機関リポジトリ) ● Metadata: 113526 (出版サイトへのリンク) ● Publication site (DOI): 10.3389/fimmu.2018.02594 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30467506 ● Summary page in Scopus @ Elsevier: 2-s2.0-85056303968 (徳島大学機関リポジトリ: 113526, DOI: 10.3389/fimmu.2018.02594, PubMed: 30467506, Elsevier: Scopus)
15.	Yukihiro Momota, Kohichi Kani, Nao Masuda, Satoru Eguchi, Ohtuka Ryo, Hideyuki Takano and Masayuki Azuma : A Case of Well-Managed Fibromyalgia with Autonomic Dysfunction during Dental Therapy: Significance of Heart Rate Variability Analysis, IOSR Journal of Dental and Medical Sciences, Vol.17, No.10, 33-35, 2018. (出版サイトへのリンク) ● Publication site (DOI): 10.9790/0853-1710033335 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-1710033335 (DOI: 10.9790/0853-1710033335)
16.	Keiko Aota, Kohichi Kani, Tomoko Yamanoi, Koh-ichi Nakashiro, Naozumi Ishimaru and Masayuki Azuma : Distinct Regulation of CXCL10 Production by Cytokines in Human Salivary Gland Ductal and Acinar Cells., Inflammation, Vol.41, No.4, 1172-1181, 2018. (要約) CXCL10, a CXC chemokine induced by interferon-gamma [IFN-γ], has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions. Although CXCL10 is known to be overexpressed in the salivary glands of individuals with primary Sjögren's syndrome (pSS), it is unclear which cells produce CXCL10 under what types of stimulations. Here, we investigated the precise molecular mechanisms by which CXCL10 was produced in human salivary gland ductal (NS-SV-DC) and acinar (NS-SV-AC) cell lines. Our results demonstrated that NS-SV-DC cells produced higher levels of CXCL10 compared to NS-SV-AC cells. In addition, our findings demonstrated that the regulator of the enhancement of CXCL10 was different between NS-SV-DC and NS-SV-AC cells, i.e., interferon-gamma (IFN-γ) had more potential than interferon-alpha (IFN-α), tumor necrosis factor (TNF)-α, and interleukin (IL)1-β in the induction of CXCL10 production in NS-SV-DC cells, whereas TNF-α had potential to induce CXCL10 production in NS-SV-AC cells. A Western blot analysis demonstrated that IFN-γ enhanced the production of CXCL10 via both the JAK/STAT1 pathway and the NF-κB pathway in NS-SV-DC cells, whereas TNF-α enhanced the production of CXCL10 via the NF-κB pathway in NS-SV-AC cells. The results of study suggest that the CXCL10 overexpression in the salivary glands is caused mainly by IFN-γ-stimulated salivary gland ductal cells. The enhanced production of CXCL10 by IFN-γ from ductal cells may result in the inflammation of pSS lesions. (キーワード) Acinar Cells / Cell Line / Chemokine CXCL10 / Cytokines / Humans / Interferon-gamma / NF-kappa B / Salivary Glands / Tumor Necrosis Factor-alpha (徳島大学機関リポジトリ) ● Metadata: 112923 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10753-018-0764-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29549479 ● Summary page in Scopus @ Elsevier: 2-s2.0-85044090734 (徳島大学機関リポジトリ: 112923, DOI: 10.1007/s10753-018-0764-0, PubMed: 29549479, Elsevier: Scopus)
17.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani, Koh-ichi Nakashiro, Naozumi Ishimaru and Masayuki Azuma : Inverse correlation between the number of CXCR3+ macrophages and the severity of inflammatory lesions in Sjögren's syndrome salivary glands: a pilot study, Journal of Oral Pathology & Medicine, Vol.47, No.7, 710-718, 2018. (要約) Mechanisms underlying immune cells' recruitment and activation into the inflammatory lesions of lip salivary glands (LSGs) from primary Sjögren's syndrome (pSS) patients are incompletely understood. Chemokines play pivotal roles in these processes, so we investigated the clinical significance of chemokine receptor CXCR3 and its ligands in the autoimmune lesions of pSS. We histologically determined the grade of LSG samples from 22 patients with pSS and subjected the samples to immunofluorescence analysis to determine the expressions of CXCR3 and its ligands: CXCL9, CXCL10, and CXCL11. To identify the immune cells expressing CXCR3 in the LSGs, we performed double immunofluorescence analysis using antibodies against CD3 (pan-T cells), CD80 (M1 macrophages), CD163 (M2 macrophages), and CD123 (plasmacytoid dendritic cells: pDCs). The relationship between the grade of lymphocytic infiltration and the number of positively stained cells was analyzed by Spearman's rank correlation test. The expressions of CXCL9 and CXCL10 showed particularly intense staining in the LSG samples' ductal cells. The CXCR3 expression was detected mainly in CD80 and CD163 macrophages. The number of CXCR3 CD163 macrophages inversely correlated with the LSG inflammatory lesions' severity (rs = -0.777, P < 0.001). Our results suggest that the enhanced production of CXCL9 and CXCL10 from ductal cells results in the CXCR3 macrophages' migration. There was an inverse correlation between these two parameters: that is, the number of CXCR3 CD163 macrophages decreased as the lymphocytic infiltration grade increased. Although CXCR3 is expressed in all of the innate immune cells, CXCR3 CD163 M2 macrophages may contribute to the anti-inflammatory functions in pSS lesions. (徳島大学機関リポジトリ) ● Metadata: 113977 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jop.12756 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29926992 ● Summary page in Scopus @ Elsevier: 2-s2.0-85050503684 (徳島大学機関リポジトリ: 113977, DOI: 10.1111/jop.12756, PubMed: 29926992, Elsevier: Scopus)
18.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二, 東雅之 : 一次性舌痛症における唾液アミラーゼ活性測定の試み, 日本口腔検査学会雑誌, Vol.10, No.1, 64-67, 2018年. (キーワード) 一次性舌痛症 / 唾液アミラーゼ活性 / 近赤外線星状神経節近傍照射 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845762642423424 (CiNii: 1050845762642423424)
19.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Yuki Miyamoto and Masayuki Azuma : Recurrent Aphthous Stomatitis Well-Treated with Inchinkoto: Two Case Reports, IOSR Journal of Dental and Medical Sciences, Vol.17, No.4, 6-11, 2018.
20.	可児耕一, 桃田幸弘, 高野栄之, 青田桂子, 山ノ井朋子, 東雅之 : Docetaxel・γ-tocotrienol併用療法による口腔癌移植ヌードマウス腫瘍への抗腫瘍効果の検討．, 口腔組織培養学会誌, Vol.27, No.1, 19-20, 2018年.
21.	Keiko Aota, Tomoko Yamanoi, Kohichi Kani and Masayuki Azuma : Cepharanthine inhibits IFN--induced CXCL10 by suppressing the JAK2/STAT1 signal pathway in human salivary gland ductal cells, Inflammation, Vol.41, No.1, 50-58, 2018. (要約) Cepharanthine, a biscolaurine alkaloid isolated from the plant Stephania cephalantha Hayata, has been reported to have potent anti-inflammatory properties. Here, we investigated the effects of cepharanthine on the expression of CXCL10 (a CXC chemokine induced by interferon-gamma [IFN-γ] that has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions) in IFN-γ-treated human salivary gland cell lines. We observed that IFN-γ-induced CXCL10 production in NS-SV-DC cells (a human salivary gland ductal cell line), but not in NS-SV-AC cells (a human salivary gland acinar cell line). Cepharanthine inhibited the IFN-γ-induced CXCL10 production in NS-SV-DC cells. A Western blot analysis showed that cepharanthine prevented the phosphorylation of JAK2 and STAT1, but did not interfere with the NF-κB pathway. Moreover, cepharanthine inhibited the IFN-γ-mediated chemotaxis of Jurkat T cells. These results suggest that cepharanthine suppresses IFN-γ-induced CXCL10 production via the inhibition of the JAK2/STAT1 signaling pathway in human salivary gland ductal cells. Our findings also indicate that cepharanthine could inhibit the chemotaxis of Jurkat T cells by reducing CXCL10 production. (徳島大学機関リポジトリ) ● Metadata: 112922 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s10753-017-0662-x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28879548 ● Search Scopus @ Elsevier (PMID): 28879548 ● Search Scopus @ Elsevier (DOI): 10.1007/s10753-017-0662-x (徳島大学機関リポジトリ: 112922, DOI: 10.1007/s10753-017-0662-x, PubMed: 28879548)
22.	桃田幸弘, 高野栄之, 可児耕一, 東雅之 : 五苓散と加工附子末製剤の併用が奏効した三叉神経痛の1例, 痛みと漢方, Vol.28, 151-155, 2018年.
23.	青田桂子, 山ノ井朋子, 高野栄之, 可児耕一, 桃田幸弘, 松本文博, 東雅之 : 徳島大学病院歯科診療所を受診したHIV感染症患者の臨床統計的検討, 有病者歯科医療, Vol.26, No.6, 444-450, 2017年. (徳島大学機関リポジトリ) ● Metadata: 113552 (徳島大学機関リポジトリ: 113552)
24.	西野豪志, 滝沢宏光, 澤田徹, 河北直也, 坪井光弘, 梶浦耕一郎, 鳥羽博明, 吉田光輝, 川上行奎, 近藤和也, 山村佳子, 東雅之 : 肺癌手術における周術期口腔機能管理の術後肺炎予防効果, 日本呼吸器外科学会雑誌, Vol.31, No.4, 432-438, 2017年. (出版サイトへのリンク) ● Publication site (DOI): 10.2995/jacsurg.31.432 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.2995/jacsurg.31.432 (DOI: 10.2995/jacsurg.31.432)
25.	西野豪志, 吉田卓弘, 井上聖也, 青山万理子, 滝沢宏光, 丹黒章, 山村佳子, 東雅之 : 外科診療におけるチーム医療の現況と展望 4．周術期の口腔ケア-食道癌，肺癌手術における周術期口腔機能管理-, 日本外科学会雑誌, Vol.118, No.2, 155-160, 2017年. (キーワード) 食道癌 / 肺癌 / 周術期 / 口腔機能管理 / 肺炎予防 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520290883087757568 (CiNii: 1520290883087757568)
26.	Tomoko Yamanoi, Keiko Aota, Yukihiro Momota and Masayuki Azuma : Treatment with the Biscoclaurine Alkaloid Cepharanthin Significantly Increases Salivary Selection in Primary Sjögren's Syndrome Patients, Journal of Oral Health and Biosciences, Vol.29, No.2, 39-48, 2017. (徳島大学機関リポジトリ) ● Metadata: 111058 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.29.2_39 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.20738/johb.29.2_39 (徳島大学機関リポジトリ: 111058, DOI: 10.20738/johb.29.2_39)
27.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, 高瀬奈緒, Yuki Miyamoto, Shinji Ono, Shigemasa Tomioka and Masayuki Azuma : A Case Series of Xerostomia Treated with Kampo Medicines: Assessment of Health-Related Quality of Life Based on the Japanese Version of the Short Form-8 Health Survey, Oral Science in Japan, Vol.2017, 79-82, 2017. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520572359919321344 (CiNii: 1520572359919321344)
28.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二, 東雅之 : 三剤併用が奏効した口腔顔面痛の3例, 日本口腔顔面痛学会雑誌, Vol.9, No.1, 53-59, 2016年. (キーワード) 三剤併用，口腔顔面痛，プレガバリン，トラマドール塩酸塩/アセトアミノフェン配合錠，加工附子末製剤 (出版サイトへのリンク) ● Publication site (DOI): 10.11264/jjop.9.53 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.11264/jjop.9.53 (DOI: 10.11264/jjop.9.53)
29.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 近藤智香, 高瀬奈緒, 宮本由貴, 東雅之 : 新規口腔ケア製品「ペプチサルシリーズ」の使用感に関する調査, 日本口腔ケア学会雑誌, Vol.11, No.1, 87-89, 2016年. (キーワード) 市販保湿剤 / 使用感 / 口腔乾燥 / Oral care products / Usability survey / Xerostomia (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523669555912256384 (CiNii: 1523669555912256384)
30.	吉岡昌美, 石川久子, 永井浩美, 伊賀弘起, 東雅之 : 外来化学療法患者の口腔健康管理に対する認識, 日本口腔ケア学会雑誌, Vol.11, No.1, 24-29, 2016年. (キーワード) 外来化学療法 / 口腔内有害事象 / 口腔健康管理 / 意識調査 / 患者教育 / outpatient chemotherapy / oral adverse event / oral health management / awareness survey / educational activity (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523388080931673088 (CiNii: 1523388080931673088)
31.	桃田幸弘, 細木眞紀, 二宮雅美, 高野栄之, 松香芳三, 東雅之 : 口腔ならびに呼吸器症状を呈した歯科用金属によるアレルギーの1例, 日本口腔検査学会雑誌, Vol.8, No.1, 39-44, 2016年.
32.	山村佳子, 滝沢宏光, 松本文博, 桃田幸弘, 青田桂子, 武川大輔, 近藤智香, 山ノ井朋子, 高野栄之, 可児耕一, 十川悠香, 河野文昭, 松尾敬志, 先山正二, 東雅之 : 胸腔鏡下肺葉切除術における周術期口腔機能管理の効果に関する検討―後ろ向き研究―, 日本口腔ケア学会雑誌, Vol.10, No.1, 106-110, 2016年. (キーワード) 胸腔鏡下肺葉切除術 / 周術期口腔機能管理 / 術後合併症 / thoracoscopic lung lobectomy / Perioperative oral management / postoperative complications (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1522262181026542720 (CiNii: 1522262181026542720)
33.	西野豪志, 滝沢宏光, 吉田卓弘, 乾友浩, 髙杉遥, 松本大資, 河北直也, 井上聖也, 先山正二, 丹黒章, 東雅之, 山村佳子 : 肺癌・食道癌の周術期における口腔ケアの現状とその効果, 胸部外科, Vol.69, No.1, 30-34, 2016年. (キーワード) 食道癌 / 肺癌 / 口腔ケア / 術後肺炎 / esophageal cancer / lung cancer / oral health care management / postoperative pneumonia (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26975640 ● CiNii @ 国立情報学研究所 (CRID): 1390283684942679808 ● Summary page in Scopus @ Elsevier: 2-s2.0-84979797876 (PubMed: 26975640, CiNii: 1390283684942679808, Elsevier: Scopus)
34.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Yamanoi Tomoko, Kondo Chika, Takase Nao, Miyamoto Yuki, Shigemasa Tomioka and Masayuki Azuma : Significance of Time-Domain Measurements of Heart Rate Variability in Burning Mouth Syndrome, IOSR Journal of Dental and Medical Sciences, Vol.15, No.1, 25-33, 2016.
35.	桃田幸弘, 東雅之 : 口腔異常感覚に対して白虎加人参湯が奏効した1症例, 漢方と診療, Vol.27, No.3, 27, 2016年.
36.	Yukihiro Momota, Yuki Miyamoto, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : A Case of Well-Managed Idiopathic Autonomic Neuropathy during Dental Therapy: Significance of Heart Rate Variability Analysis, Oral Science in Japan, Vol.2016, 37-8, 2016.
37.	Minami Sato, Shingo Kuroda, MANSJUR KARIMA QURNIA, KHALIUNAA GANZORIG, Kumiko Nagata, Shinya Horiuchi, Toshihiro Inubushi, Yoshiko Yamamura, Masayuki Azuma and Eiji Tanaka : Low-intensity pulsed ultrasound rescues insufficient salivary secretion in autoimmune sialadenitis., Arthritis Research & Therapy, Vol.17, 2015. (要約) TNF-α stimulation of NS-SV-AC and NS-SV-DC cells resulted in a significant decrease in cell number and net fluid secretion rate (p < 0.01), whereas LIPUS treatment abolished them (p < 0.05). The expression changes of AQP5 and TNF-α were also inhibited in LIPUS treatment by blocking the NF-κB pathway. Furthermore, we found that mRNA expression of A20, a negative feedback regulator, was significantly increased by LIPUS treatment after TNF-α or interleukin 1β stimulation (NS-SV-AC, p < 0.01; NS-SV-DC, p < 0.05). In vivo LIPUS exposure to MRL/lpr mice exhibited a significant increase in both salivary flow and AQP5 expression by reducing inflammation in salivary glands (p < 0.01). (徳島大学機関リポジトリ) ● Metadata: 109706 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s13075-015-0798-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26445930 ● Search Scopus @ Elsevier (PMID): 26445930 ● Search Scopus @ Elsevier (DOI): 10.1186/s13075-015-0798-8 (徳島大学機関リポジトリ: 109706, DOI: 10.1186/s13075-015-0798-8, PubMed: 26445930)
38.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano and Masayuki Azuma : Cerebellopontine Angle Mass Mimicking Lingual Nerve Injury after Dental Implant Placement: A Case Report., Australian Dental Journal, Vol.60, No.3, 412-5, 2015. (要約) This is a rare case report of a cerebellopontine angle (CPA) mass mimicking lingual nerve injury after a dental implant placement. Lingual nerve injury is a common complication following dental implant placement. CPA masses are likely to cause symptomatic trigeminal neuralgia, and thus can mimic and be easily confused with oral diseases. We experienced a case of CPA mass mimicking lingual nerve injury after dental implant placement. The patient was a 57-year-old Japanese female and complained of glossalgia. She underwent dental implant placement in the mandible before visiting our clinic. Panoramic x-ray radiography revealed no abnormalities; the salivary flow rate by gum test was 7.0 ml/10 min. She was diagnosed with lingual nerve injury and secondary burning mouth syndrome. Vitamin B12 and oral moisturizer did not provide relief; furthermore, numbness in the lower lip emerged. A Semmes Weinstein test demonstrated elevation of her sensitivity threshold. Finally, magnetic resonance imaging revealed a 20-mm-diameter mass in the CPA. The patient is now being followed under conservative management. Our experience underscores the importance of including CPA mass in the differential diagnosis of dental diseases. This article is protected by copyright. All rights reserved. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/adj.12224 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25280059 ● Search Scopus @ Elsevier (PMID): 25280059 ● Search Scopus @ Elsevier (DOI): 10.1111/adj.12224 (DOI: 10.1111/adj.12224, PubMed: 25280059)
39.	桃田幸弘, 東雅之 : 対応に苦慮した口腔異常感覚に対して五苓散が奏効した1症例, 漢方医学, Vol.39, No.2, 190-192, 2015年. (キーワード) 口腔異常感覚 / 五苓散 / Short Form-8 Health Survey / 健康関連QOL (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1523951029528558976 (CiNii: 1523951029528558976)
40.	Yukihiro Momota, Hideyuki Takano and Masayuki Azuma : Pregabalin Relieved Gingival Pruritus Associated with Oral Dysesthesia: A Case Report, IOSR Journal of Dental and Medical Sciences, Vol.14, No.8, 01-02, 2015. (出版サイトへのリンク) ● Publication site (DOI): 10.9790/0853-14830102 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-14830102 (DOI: 10.9790/0853-14830102)
41.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 近藤智香, 高瀬奈緒, 宮本由貴, 東雅之 : 一次性舌痛症に関する健康関連QOLの調査-MOS 36-Item Short-Form Health Survey Version 2日本語版を用いて-, 日本口腔内科学会雑誌, Vol.21, No.1, 9-14, 2015年. (要約) 一次性舌痛症は舌痛を訴えるものの確たる要因を見出せず，未だ十分な理解には達していない．MOS 36-Item Short-Form Health Survey Version 2 (SF-36v2)日本語版は健康関連QOL(Health-Related Quality of Life)の尺度である．今般，われわれはSF-36v2日本語版を用いて本疾患に関する健康関連QOLを調査した．2007年1月から2014年12月までに徳島大学病院口腔内科を受診した一次性舌痛症患者26名を対象とした．女性は男性と比較して，総じてSF-36v2下位尺度のスコアが低下し，高齢者では顕著であった．本疾患の病態は加齢によって複雑化し，高齢者に対する治療目標は疼痛だけに固執せず，心理・社会的問題に対する配慮も要すると考えられた．SF-36v2日本語版による健康関連QOLの調査は本疾患の理解と治療目標の設定において有意義であった． (キーワード) 一次性舌痛症 / 健康関連QOL / SF-36v2 / primary glossodynia / health-related quality of life / MOS 36-item short-from health survey version 2 (出版サイトへのリンク) ● Publication site (DOI): 10.6014/jjsom.21.9 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205424141312 ● Search Scopus @ Elsevier (DOI): 10.6014/jjsom.21.9 (DOI: 10.6014/jjsom.21.9, CiNii: 1390001205424141312)
42.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, Chika Kondo, Nao Takase, Yuki Miyamoto, Shigemasa Tomioka and Masayuki Azuma : A Case Series of Burning Mouth Syndrome Treated with Stellate Ganglion Near-Infrared Irradiation: Assessment of HealthRelated Quality of Life Based on the Japanese Version of the MOS 36-Item Short-Form Health Survey Version 2, IOSR Journal of Dental and Medical Sciences, Vol.14, No.6, 39-43, 2015. (出版サイトへのリンク) ● Publication site (DOI): 10.9790/0853-14643943 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9790/0853-14643943 (DOI: 10.9790/0853-14643943)
43.	Yukihiro Momota, Shigemasa Tomioka, Ryo Otsuka, Daisuke Shioguri, Hideyuki Takano and Masayuki Azuma : Well-Managed Postural Orthostatic Tachycardia Syndrome during Dental Therapy and Analysis of Heart Rate Variability: A Case Report, IOSR Journal of Dental and Medical Sciences, Vol.14, No.5, 23-26, 2015. (出版サイトへのリンク) ● Publication site (DOI): 10.6084/M9.FIGSHARE.1421905 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.6084/M9.FIGSHARE.1421905 (DOI: 10.6084/M9.FIGSHARE.1421905)
44.	Masayuki Azuma, Takanori Fujimura, Takashi Fujimoto, Tomoko Miyaoka and Shin Takasawa : Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG Ia, a new auto-antigen in Sjogren's syndrome patients, in salivary duct epithelial cells., Biochemistry and Biophysics Reports, Vol.2, No.1, 69-74, 2015. (キーワード) REgenerating gene / Interleukin-6 / シェーグレン症候群 (Sjögren's syndrome) (徳島大学機関リポジトリ) ● Metadata: 115020 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.bbrep.2015.05.006 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-84937028326 (徳島大学機関リポジトリ: 115020, DOI: 10.1016/j.bbrep.2015.05.006, Elsevier: Scopus)
45.	山村佳子, 青田桂子, 桃田幸弘, 松本文博, 長井幸二郎, 東雅之 : 徳島大学病院における慢性腎臓病患者の口腔管理について, 日本口腔ケア学会雑誌, Vol.9, No.1, 23-27, 2015年. (キーワード) 慢性腎臓病 / ステロイド治療 / ビスフォスフォネート製剤 / chronic kidney diseases / steroid preparation / bisphosphonate preparation (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1524232505861982208 (CiNii: 1524232505861982208)
46.	吉岡昌美, 永井浩美, 石川久子, 東雅之, 河野文昭, 松尾敬志 : 徳島県下の地域歯科診療所における病院・施設への往診/訪問歯科診療の現状, 四国公衆衛生学会雑誌, Vol.60, No.1, 103-107, 2015年.
47.	Hideyuki Takano, Yukihiro Momota, Kohichi Kani, Keiko Aota, Yoshiko Yamamura, Yamanoi Tomoko and Masayuki Azuma : γ-tocotrienol prevents 5-FU-induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5-FU-induced activation of Nrf2, International Journal of Oncology, Vol.46, No.4, 1453-1460, 2015. (要約) Chemotherapy induced oral mucositis is a common adverse event in patients with oral squamous cell carcinoma, and is initiated through a variety of mechanisms, including the generation of reactive oxygen species (ROS). In this study, we examined the preventive effect of γ tocotrienol on the 5 FU induced ROS production in human oral keratinocytes (RT7). We treated RT7 cells with 5 FU and γ tocotrienol at concentrations of 10 µg/ml and 10 nM, respectively. When cells were treated with 5 FU alone, significant growth inhibition was observed as compared to untreated cells. This inhibition was, in part, due to the ROS gene rated by 5 FU treatment, because N acetyl cysteine (NAC), a ROS scavenger, significantly ameliorated the growth of RT7 cells. γ tocotrienol showed no cytotoxic effect on the growth of RT7 cells. Simultaneous treatment of cells with these agents resulted in the significant recovery of cell growth, owing to the suppression of ROS generation by γ tocotrienol. Whereas 5 FU stimulated the expression of NF E2 related factor 2 (Nrf2) protein in the nucleus up to 12 h after treatment of RT7 cells, γ tocotrienol had no obvious effect on the expression of nuclear Nrf2 protein. Of note, the combined treatment with both agents stabilized the 5 FU induced nuclear Nrf2 protein expression until 24 h after treatment. In addition, expression of Nrf2 dependent antioxidant genes, such as heme oxygenase 1 (HO 1) and NAD(P)H:quinone oxidoreductase 1 (NQO 1), was significantly augmented by treatment of cells with both agents. These findings suggest that γ tocotrienol could prevent 5 FU induced ROS generation by stabilizing Nrf2 activation, thereby leading to ROS detoxification and cell survival in human oral keratinocytes. (徳島大学機関リポジトリ) ● Metadata: 109341 (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ijo.2015.2849 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25625649 ● Summary page in Scopus @ Elsevier: 2-s2.0-84923112564 (徳島大学機関リポジトリ: 109341, DOI: 10.3892/ijo.2015.2849, PubMed: 25625649, Elsevier: Scopus)
48.	青田桂子, 山村佳子, 山ノ井朋子, 武川大輔, 可児耕一, 高野栄之, 桃田幸弘, 松本文博, 菅原千恵子, 吉岡昌美, 河野文昭, 松尾敬志, 東雅之 : 徳島大学病院における周術期口腔機能管理の現状と課題, Journal of Oral Health and Biosciences, Vol.28, No.1, 29-36, 2015年. (要約) It has been shown that oral hygiene affects the onset of perioperative complications. The usefulness of perioperative oral function management aiming at the outbreak decrease in treatment complications and an early discharge was recognized. As a result, perioperative oral function management fee was founded at revision of medical service fees in Fiscal year 2012. In this clinical study, we evaluated the implementation of perioperative oral function management in Tokushima University Hospital. We examined 781 patients, including 563 patients for surgery and 218 patients for chemotherapy and radiotherapy. The mean age of patients was 58.8 ± 12.4 years old. The implementation rate of perioperative oral function management was 9.7% in the patients of surgery, and 17.4% in those of chemotherapy and radiotherapy. The highly required medical department was neurosurgery in the patients of surgery, and hematology in those of chemotherapy and radiotherapy. The mean number of tooth present was 21.3 ± 7.1 in the patients of surgery, and 19.8 ± 7.2 in those chemotherapy and radiotherapy. The rate of dental treatment was required in 40.5% of total patients who received surgery, and in 51.4% of patients who received chemotherapy and radiotherapy.The rate of patients who received denture treatment attained to 11.9% of the whole patients receiving surgery, and 13.3% of patients receiving chemotherapy and radiotherapy. It was revealed that there were many patients required potential demands in perioperative oral function management, and that there were many patients who need dental or denture treatment. We would like to develop perioperative oral function management by the interprofessional collaboration in health and social care.7月発行だが，6月号である． (キーワード) 徳島大学病院 / 周術期口腔機能管理 / チーム医療 (徳島大学機関リポジトリ) ● Metadata: 109866 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050564287418444544 (徳島大学機関リポジトリ: 109866, CiNii: 1050564287418444544)
49.	可児耕一, 桃田幸弘, 高野栄之, 青田桂子, 山ノ井朋子, 東雅之 : 口腔癌担癌ヌードマウスに対するdocetaxelおよびγ-tocotrienolの併用による抗腫瘍効果の検討, 日口組織培養誌, Vol.24, No.2, 23-30, 2015年.
50.	山村佳子, 青田桂子, 武川大輔, 十川悠香, 近藤智香, 山ノ井朋子, 高野栄之, 可児耕一, 松本文博, 桃田幸弘, 里見淳一郎, 河野文昭, 松尾敬志, 永廣信治, 東雅之 : 徳島大学病院脳卒中センターにおける口腔管理の意義について, Journal of Oral Health and Biosciences, Vol.9, No.1, 37-41, 2015年.
51.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Keiko Aota, Daisuke Takegawa, Yamanoi Tomoko, Kondo Chika, Shigemasa Tomioka and Masayuki Azuma : High-Wattage Pulsed Irradiation of Linearly Polarized Near-Infrared Light to Stellate Ganglion Area for Burning Mouth Syndrome, Case Reports in Dentistry, 2014. (要約) The purpose of this study was to apply high-wattage pulsed irradiation of linearly polarized near-infrared light to the stellate ganglion area for burning mouth syndrome (BMS) and to assess the efficacy of the stellate ganglion area irradiation (SGR) on BMS using differential time-/frequency-domain parameters (D parameters). Three patients with BMS received high-wattage pulsed SGR; the response to SGR was evaluated by visual analogue scale (VAS) representing the intensity of glossalgia and D parameters used in heart rate variability analysis. High-wattage pulsed SGR significantly decreased the mean value of VAS in all cases without any adverse event such as thermal injury. D parameters mostly correlated with clinical condition of BMS. High-wattage pulsed SGR was safe and effective for the treatment of BMS; D parameters are useful for assessing efficacy of SGR on BMS. (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2014/171657 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25386367 ● Search Scopus @ Elsevier (PMID): 25386367 ● Search Scopus @ Elsevier (DOI): 10.1155/2014/171657 (DOI: 10.1155/2014/171657, PubMed: 25386367)
52.	Yukihiro Momota, Shigemasa Tomioka, Mayuko Furukita, Kenji Fujisawa, Hideyuki Takano and Masayuki Azuma : Orthostatic Dysregulation during Postural Change on the Dental Chair and Intraoperative Monitoring by Heart Rate Variability Analysis., Case Reports in Dentistry, Vol.2014, 2014. (要約) This is the first case report of orthostatic dysregulation (OD) manifested during postural change on the dental chair and intraoperatively monitored by heart rate variability (HRV) analysis. OD-associated autonomic dysfunction is induced by postural changes and easily leads to disturbance in circulatory dynamics; however, most dental practices have not yet realized the importance of managing OD. We measured autonomic activity in a patient with OD during dental therapy and assessed the clinical significance of HRV analysis for OD. The patient was a 17-year-old Japanese female. She was diagnosed with impacted wisdom teeth and had no previous history of a distinct systemic disease. A surgical procedure to extract the teeth was safely performed under both local anesthesia and sedation with nitrous oxide and midazolam. After the surgery, her postural change to sitting induced orthostatic hypotension. HRV variables showed parasympathetic dominance due to the upright position. Subsequently, her posture was returned to supine, and atropine sulfate administration for the immediate treatment of OD returned her blood pressure to normal levels. HRV variables showed relative sympathetic dominance due to an atropine-derived parasympathetic blockade. HRV analysis revealed OD-associated autonomic dysfunction and should become a standard tool for safe and secure dental management of OD. (出版サイトへのリンク) ● Publication site (DOI): 10.1155/2014/656045 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25045545 ● Search Scopus @ Elsevier (PMID): 25045545 ● Search Scopus @ Elsevier (DOI): 10.1155/2014/656045 (DOI: 10.1155/2014/656045, PubMed: 25045545)
53.	桃田幸弘, 高野栄之, 可児耕一, 高石和美, 中川弘, 富岡重正, 郡由紀子, 橋本俊顕, 北畑洋, 東雅之 : いわゆる病病連携による障害者歯科医療連携が奏功した集学的歯科治療について, 四国歯学会雑誌, Vol.26, No.2, 35-40, 2014年.
54.	高野栄之, 桃田幸弘, 山村佳子, 田岡計久, 東雅之 : インプラント埋入後に生じたオトガイ神経麻痺が契機となり診断に至った下顎骨悪性リンパ腫の1例, 日本口腔インプラント学会誌, Vol.27, No.2, 170-174, 2014年. (要約) We present a case of malignant lymphoma of the mandible diagnosed by coincidentally-developed mental hypoesthesia after placement of a dental implant. A 60-year old woman who underwent dental implant placement by a dental practitioner visited our hospital because of postoperative mental hypoesthesia. Orthopantomography and CT revealed perforated bone defects at the posterior molar and ramus region of the mandible, but could not demonstrate a causal relationship between the implantation and the hypoesthesia. In blood test results, the values of sIL-2R and LDH were abnormally elevated. A tumor arising from soft tissue around the molar region was biopsied, and a diagnosis of diffuse large B-cell lymphoma was confirmed histopathologically. This tumor was treated at the Department of Hematology by the R-CHOP chemotherapy regimen, resulting in complete remission of the tumor, and masticatory function was adequately restored using dental implants. It was concluded that early detection and rapid cure are the key to maintaining oral function. (キーワード) dental implant placement / mental hypoesthesia / malignant lymphoma of the mandible / dental implant placement / mental hypoesthesia / malignant lymphoma of the mandible (出版サイトへのリンク) ● Publication site (DOI): 10.11237/jsoi.27.170 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680486454272 ● Search Scopus @ Elsevier (DOI): 10.11237/jsoi.27.170 (DOI: 10.11237/jsoi.27.170, CiNii: 1390282680486454272)
55.	桃田幸弘, 可児耕一, 高野栄之, 松本文博, 青田桂子, 武川大輔, 山ノ井朋子, 近藤智香, 東雅之 : 一次性舌痛症における手掌部発汗の発現-皮膚水分量測定の有用性について-, 日本歯科人間ドック学会誌, Vol.9, 18-23, 2014年.
56.	茂木勝美, 桃田幸弘, 高野栄之, 可児耕一, 山村佳子, 東雅之 : 抜歯後の止血困難をきっかけに発見された後天性血友病Aの1例, 日本口腔外科学会雑誌, Vol.59, No.12, 786-790, 2013年. (要約) Acquired hemophilia A is a rare disease. It is caused by the acquirement of factor VIII inhibitor. We report a case of acquired hemophilia A incidentally diagnosed on bleeding after tooth extraction. A 75-yearold woman referred to our hospital because of bleeding after tooth extraction. Hematological examination revealed a prolonged activated partial thromboplastin time (APTT) and decreased coagulation activity of factor VIII. In addition, a high level of factor VIII inhibitor was detected. Therefore, our patient was given a diagnosis of acquired hemophilia A. The patient was admitted to our hospital and received corticosteroids and bypass hemostasis using recombinant coagulation factor VII. On hospital day 42, APTT and factor VIII activity returned to the normal range. Moreover, factor VIII inhibitor disappeared. The patient was discharged and is being treated at a local general hospital. (キーワード) acquiredhemophilia(後天性血友病) / factorⅧinhibitor(第Ⅷ因子インヒビター) / toothextraction(抜歯) (出版サイトへのリンク) ● Publication site (DOI): 10.5794/jjoms.59.786 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001206533265664 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.59.786 (DOI: 10.5794/jjoms.59.786, CiNii: 1390001206533265664)
57.	Keiko Aota and Masayuki Azuma : Targeting TNF- suppresses the production of MMP-9 in human salivary gland cells., Archives of Oral Biology, Vol.58, No.12, 1761-1768, 2013. (要約) Tumour necrosis factor- (TNF-) is a pleiotropic cytokine that plays an essential role in inflammation and apoptosis. Our previous study suggested that TNF--induced activation of matrix metalloproteinase-9 (MMP-9) resulted in the destruction of acinar tissue in the salivary glands of patients with Sjögren's syndrome (SS) via disruption of the acinar cell-basement membrane. Recently, a wide array of biological agents has been designed to inhibit TNF, including etanercept and adalimumab. In this study, we demonstrate the suppressive effect of anti-TNF agents on TNF--induced MMP-9 production in NS-AV-AC, an immortalized human salivary gland acinar cell line. NS-AV-AC cells were treated with etanercept or adalimumab after TNF- treatment. MMP-9 production and enzymatic activity were, respectively, visualized by real-time PCR and ELISA assay, and evaluated by gelatin zymography, and apoptosis was evaluated by DNA fragmentation assay. TNF- induced the production of MMP-9 in NS-SV-AC cells. However, this production was greatly inhibited by treatment with etanercept or adalimumab. In addition, TNF--induced DNA fragmentation was prevented by treatment with etanercept or adalimumab. These results may indicate that anti-TNF agents would have therapeutic efficacy for preventing destruction of the acinar structure in the salivary glands of patients with SS. (キーワード) Acinar Cells / Antibodies, Monoclonal, Humanized / Antirheumatic Agents / Apoptosis / Cell Line / DNA Fragmentation / Electrophoresis, Polyacrylamide Gel / Enzyme-Linked Immunosorbent Assay / Gene Expression / Humans / Immunoglobulin G / Matrix Metalloproteinase 9 / RNA, Messenger / Real-Time Polymerase Chain Reaction / Receptors, Tumor Necrosis Factor / Salivary Glands / Sjogren's Syndrome / Tumor Necrosis Factor-alpha (徳島大学機関リポジトリ) ● Metadata: 113553 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.archoralbio.2013.09.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24200302 ● Search Scopus @ Elsevier (PMID): 24200302 ● Search Scopus @ Elsevier (DOI): 10.1016/j.archoralbio.2013.09.004 (徳島大学機関リポジトリ: 113553, DOI: 10.1016/j.archoralbio.2013.09.004, PubMed: 24200302)
58.	青田桂子, 山村佳子, 可児耕一, 高野栄之, 茂木勝美, 桃田幸弘, 石丸直澄, 東雅之 : Sjogren症候群患者の唾液腺腺房構造破壊阻止 : セファランチンの有効性に関する臨床病理学的研究, 日本口腔科学会雑誌, Vol.62, No.4, 254-261, 2013年. (要約) Sjögren's syndrome (SS) is characterized by the eventual total replacement of the acinar structure by marked infiltration of lymphocytes into the salivary and lacrimal glands. We previously demonstrated that tumor necrosis factor-α (TNF-α) induced matrix metalloproteinase-9 (MMP-9) production by the stimulating transcription factor, nuclear factor-κB (NF-κB), in human salivary gland acinar cells and that cepharanthin, a biscoclaurine alkaloid, prevented the activation of TNF-α-induced NF-κB activity. In addition, we have shown that cepharanthin prevented the destruction of acinar tissues in murine SS. Thus, in this study, we investigated the clinicopathological effect of cepharanthin on the patients with SS. <br>Ten patients with a diagnosis of primary SS were enrolled in this study. They were treated with cepharanthin for three months, followed by the evaluation of salivary production, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-SS-A antibody, anti-SS-B antibody, pathological examination of labial salivary gland biopsy specimens, and the symptom of drymouth. <br>Average salivary production was 4.25ml/10minutes before the study. This average production increased to 6.46ml/10minutes after the study. There were no remarkable changes in CRP, ESR, anti-SS-A antibody and anti-SS-B antibody. In pathological findings, although the decreases in infiltration of lymphocytes were observed in 5 out of 5 cases, the reduction of destruction of acinar structures was clearly detected in 5 cases. Improvement of symptom of drymouth was detected in 7 out of 10 cases. <br>These observations suggest that cepharanthin treatment might provide an efficient and useful therapeutic approach for countering the destruction of acinar tissue in salivary glands of patients with SS. (キーワード) Sjogren'ssyndrome(Sjogren症候群) / cepharanthin(セファランチン) / salivaryglandacinarcell(唾液腺腺房細胞) (出版サイトへのリンク) ● Publication site (DOI): 10.11277/stomatology.62.254 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001206436002048 ● Search Scopus @ Elsevier (DOI): 10.11277/stomatology.62.254 (DOI: 10.11277/stomatology.62.254, CiNii: 1390001206436002048)
59.	青田桂子, 高野栄之, 細川浩良, 可児耕一, 山村佳子, 東雅之 : リツキシマブの投与によって生じた口腔・上部消化管潰瘍の1例, 日本口腔外科学会雑誌, Vol.59, No.7, 478-482, 2013年. (キーワード) rituximab(リツキシマブ) / oral,pharyngeal,esophageal,andgastriculcer(口腔・咽頭・食道・胃潰瘍) / delayed-onsetneutropenia(遅発性好中球減少症) / Waldenstrommacroglobulinemia(原発性マクログロプリン血症) (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001206533368832 (CiNii: 1390001206533368832)
60.	桃田幸弘, 細川浩良, 高野栄之, 可児耕一, 松本文博, 茂木勝美, 青田桂子, 山村佳子, 大守真由子, 東雅之 : 口腔白板症の臨床病理学的検討-悪性化に関する臨床病理学的指標について-, 日本口腔検査学会雑誌, Vol.5, No.1, 26-30, 2013年. (キーワード) oral leukoplakia / epithelial dysplasia / malignant transformation (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050001337712179328 (CiNii: 1050001337712179328)
61.	山村佳子, 桃田幸弘, 松本文博, 茂木勝美, 青田桂子, 高野栄之, 大守真由子, 河野文昭, 東雅之 : 徳島大学病院内の口腔ケア依頼状況, 日本口腔ケア学会雑誌, Vol.7, No.1, 31-35, 2013年. (キーワード) 有病者 / 口腔ケア / 歯科的介入 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1522543656003631232 (CiNii: 1522543656003631232)
62.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura, Mayuko Omori, Shigemasa Tomioka and Masayuki Azuma : Frequency analysis of heart rate variability: a useful assessment tool of linearly polarized near-infrared irradiation to stellate ganglion area for burning mouth syndrome., Pain Medicine, Vol.14, No.3, 351-357, 2013. (要約) Burning mouth syndrome (BMS) is characterized by the following subjective complaints without distinct organic changes: burning sensation in mouth or chronic pain of tongue. BMS is also known as glossodynia; both terms are used equivalently in Japan. Although the real cause of BMS is still unknown, it has been pointed out that BMS is related to some autonomic abnormality, and that stellate ganglion near-infrared irradiation (SGR) corrects the autonomic abnormality. Frequency analysis of heart rate variability (HRV) is expected to be useful for assessing autonomic abnormality. This study investigated whether frequency analysis of HRV could reveal autonomic abnormality associated with BMS, and whether autonomic changes were corrected after SGR. Eight subjects received SGR; the response to SGR was assessed by frequency analysis of HRV. No significant difference of autonomic activity concerning low-frequency (LF) norm, high-frequency (HF) norm, and low-frequency/high-frequency (LF/HF) was found between SGR effective and ineffective groups. Therefore, we proposed new parameters: differential normalized low frequency (D LF norm), differential normalized high frequency (D HF norm), and differential low-frequency/high-frequency (D LF/HF), which were defined as differentials between original parameters just before and after SGR. These parameters as indexes of responsiveness of autonomic nervous system (ANS) revealed autonomic changes in BMS, and BMS seems to be related to autonomic instability rather than autonomic imbalance. Frequency analysis of HRV revealed the autonomic instability associated with BMS and enabled tracing of autonomic changes corrected with SGR. It is suggested that frequency analysis of HRV is very useful in follow up of BMS and for determination of the therapeutic efficacy of SGR. (キーワード) Adult / Aged / Aged, 80 and over / Autonomic Nervous System Diseases / Burning Mouth Syndrome / Female / Heart Rate / Humans / Male / Middle Aged / Stellate Ganglion / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1111/pme.12008 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23240990 ● Summary page in Scopus @ Elsevier: 2-s2.0-84875054662 (DOI: 10.1111/pme.12008, PubMed: 23240990, Elsevier: Scopus)
63.	Kohichi Kani, Yukihiro Momota, Michito Harada, Yoshiko Yamamura, Keiko Aota, Tomoko Yamanoi, Hideyuki Takano, Katsumi Motegi and Masayuki Azuma : γ-tocotrienol enhances the chemosensitivity of human oral cancer cells to docetaxel through the down regulation of the expression of NF-kB-regulated anti-apoptotic gene products., International Journal of Oncology, Vol.42, No.1, 75-82, 2013. (要約) Taxanes, including docetaxel, are widely used for the treatment of squamous cell carcinoma of the head and neck. However, the gastrointestinal toxicity of docetaxel has limited its high-dose clinical use. In this study, we examined the synergistic anticancer effects of combined low-dose docetaxel and γ-tocotrienol treatment on human oral cancer (B88) cells. We treated B88 cells with docetaxel and γ-tocotrienol at concentrations of 0.5 nM and 50 µM, respectively. When cells were treated with either agent alone at a low dose, no significant cytotoxic effect was observed. However, the simultaneous treatment of cells with both agents almost completely suppressed cell growth. Whereas docetaxel stimulated the expression of nuclear factor-κB (NF-κB) p65 protein in B88 cells, γ-tocotrienol slightly inhibited the expression of constitutive nuclear p65 protein. Of note, the combined treatment with both agents inhibited docetaxel-induced nuclear p65 protein expression. Electrophoretic mobility shift assay (EMSA) revealed that the simultaneous treatment with these agents suppressed the NF-κB DNA binding activity in B88 cells. In addition, γ-tocotrienol downregulated the docetaxel-induced expression of NF-κB-regulated gene products associated with the inhibition of apoptosis. Furthermore, the activation of initiator caspases, caspases-8 and -9, and the effector caspase, caspase-3, was detected following treatment with both agents. Finally, apoptosis was also clearly observed as demonstrated by the cleavage of poly(ADP-ribose) polymerase (PARP) and nuclear fragmentation through the activation of caspase-3 by combined treatment with docetaxel and γ-tocotrienol. These findings suggest that the combination treatment with these agents may provide enhanced therapeutic response in oral cancer patients, while avoiding the toxicity associated with high-dose β-tubulin stabilization monotherapy. (キーワード) Antineoplastic Agents / アポトーシス (apoptosis) / Apoptosis Regulatory Proteins / Blotting, Western / Caspase 3 / Cell Nucleus / Cell Proliferation / Chromans / Cytoplasm / Down-Regulation / Drug Resistance, Neoplasm / Electrophoretic Mobility Shift Assay / Humans / Mouth Neoplasms / NF-kappa B / Peptide Library / Poly(ADP-ribose) Polymerases / Taxoids / Tumor Cells, Cultured / Vitamin E (出版サイトへのリンク) ● Publication site (DOI): 10.3892/ijo.2012.1692 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23138939 ● Summary page in Scopus @ Elsevier: 2-s2.0-84873667169 (DOI: 10.3892/ijo.2012.1692, PubMed: 23138939, Elsevier: Scopus)
64.	高野栄之, 桃田幸弘, 可児耕一, 山村佳子, 松本文博, 茂木勝美, 東雅之 : イムノクロマト法による口腔カンジダ症迅速診断の臨床的有用性, 日歯人間ドック学会誌, Vol.8, No.1, 57-60, 2013年.
65.	青田桂子, 山村佳子, 大守真由子, 山田祐子, 可児耕一, 高野栄之, 茂木勝美, 桃田幸弘, 松本文博, 東雅之 : 精神科神経科入院患者の口腔環境評価と専門的口腔ケアの有用性について, 有病者歯科医療, Vol.22, No.2, 83-90, 2013年.
66.	大守真由子, 青田桂子, 山村佳子, 山田佑子, 可児耕一, 高野栄之, 茂木勝美, 桃田幸弘, 松本文博, 東雅之 : 徳島大学病院精神科神経科入院患者に対する口腔ケアの意義, 四国歯学会雑誌, Vol.25, No.2, 55-60, 2013年. (徳島大学機関リポジトリ) ● Metadata: 109829 (徳島大学機関リポジトリ: 109829)
67.	Yukihiro Momota, Shigemasa Tomioka, Mayuko Furukita, Toyoko Satsuma, Hideyuki Takano and Masayuki Azuma : Adrenergic urticaria and glossalgia induced by stress during dental therapy and monitored by heart variability analysis: A case report, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, Vol.25, 264-266, 2013. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ajoms.2013.02.008 (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-84880725006 (DOI: 10.1016/j.ajoms.2013.02.008, Elsevier: Scopus)
68.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 茂木勝美, 青田桂子, 山村佳子, 大守真由子, 東雅之 : 舌痛などの舌症状を主訴とする患者の臨床統計学的検討—舌痛症の特異性についてー., 日本口腔顔面痛学会雑誌, Vol.5, No.1, 27-35, 2012年. (要約) 目的:舌痛の器質的要因をスクリーニングする系統的診断システムを提案し，本法によって診断された舌痛関連疾患を検討する．方法:2007年1月から2009年12月までに舌痛などの舌症状を主訴としてで徳島大学病院歯科口腔外科を受診した患者104名(男性12名，女性92名，平均68歳2か月)を臨床統計学的に検討した．病歴聴取，口腔内・外診査，パノラマエックス線検査，血液検査，培養検査および唾液分泌検査を行った．局所麻酔薬と非ステロイド性抗炎症薬の効果も確認した．結果:原因疾患は口腔カンジダ症，口腔乾燥症，舌炎，舌痛症などであった．器質的変化や自覚症状の乏しい口腔カンジダ症や口腔乾燥症が認められた．舌痛症の多くは舌尖に発現し，食餌性刺激による誘発痛や圧痛が認められないものが多く，局所麻酔薬や非ステロイド系抗炎症薬の効果も乏しかった．舌痛症における味覚異常や低亜鉛血症の発現頻度は低く，手掌部発汗が高頻度に認められた．結論:培養検査や唾液分泌検査が不可欠であり，器質的変化や自覚症状の乏しい口腔カンジダ症や口腔乾燥症は舌痛症と診断される可能性があった．舌尖部疼痛を有し，食餌性刺激による誘発痛や圧痛がないことが舌痛症特異的な所見と考えられ，その病態に舌粘膜障害の関与は否定的であった．味覚障害や低亜鉛血症は舌痛症特異的な所見ではなかった．手掌部発汗は舌痛症特異的な所見と考えられ，その病態に自律神経異常の関与が示唆された． (キーワード) 舌痛 / 舌痛症 / 診断 (出版サイトへのリンク) ● Publication site (DOI): 10.11264/jjop.5.27 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205301100160 ● Search Scopus @ Elsevier (DOI): 10.11264/jjop.5.27 (DOI: 10.11264/jjop.5.27, CiNii: 1390001205301100160)
69.	桃田幸弘, 茂木勝美, 青田桂子, 高野栄之, 可児耕一, 東雅之 : ワルファリン療法中に急速に増大・破裂した軟硬口蓋粘膜下血腫の1例, 日本口腔内科学会雑誌, Vol.18, No.2, 68-71, 2012年. (要約) ワルファリン療法中に急速に増大・破裂した軟硬口蓋粘膜下血腫の1例を経験した．<br>症例は76歳，男性．食事中，急に口蓋が腫脹し，呼吸困難を訴え救急搬送された．発作性心房細動，糖尿病，高血圧症でワルファリン療法中であった．正球性貧血とPT-INR値は1.52を呈した．呼吸・循環動態に異常なく，軟硬口蓋粘膜が広範に剥離していたが，圧迫止血後，粘膜弁を縫合閉鎖した．<br>症例は留意すべき口腔の出血性合併症であった． (キーワード) ワルファリン / 出血性合併症 / 軟硬口蓋粘膜下血腫 / warfarin / bleeding complication / soft and hard platine submucous hematoma (出版サイトへのリンク) ● Publication site (DOI): 10.6014/jjsom.18.68 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282680400080640 ● Search Scopus @ Elsevier (DOI): 10.6014/jjsom.18.68 (DOI: 10.6014/jjsom.18.68, CiNii: 1390282680400080640)
70.	細川浩良, 桃田幸弘, 藤澤健司, 可児耕一, 東雅之 : 上顎に発生した歯牙エナメル上皮腫の1例, 日本口腔外科学会雑誌, Vol.58, No.8, 480-484, 2012年. (要約) Odontoameloblastoma is a rare odontogenic tumor, in which dentin and enamel are formed. Histologically, odontoameloblastoma is similar to ameloblastoma. We report a case of odontoameloblastoma arising in the maxilla.<br>A 12-year-old boy complained of swelling and pain at the incisor region on the left side of the maxilla and visited our department. Computed tomography showed a unilocular radiolucency, in which many calcified bodies were observed around the impacted canine. The clinical diagnosis was an odontogenic tumor, and the lesion was extirpated under general anesthesia. Histopathological examination of the resected specimens showed the presence of hard tissues, enamel, and dentin, accompanied by an enamel organ. Consequently, the tumor was diagnosed to be an odontoameloblastoma. There has been no evidence of recurrence for 3.5 years after the operation. (キーワード) odontoameloblastoma(歯牙エナメル上皮腫) / odontogenictumor(歯原性腫瘍) / maxilla(上顎骨) (出版サイトへのリンク) ● Publication site (DOI): 10.5794/jjoms.58.480 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390282681508695424 ● Search Scopus @ Elsevier (DOI): 10.5794/jjoms.58.480 (DOI: 10.5794/jjoms.58.480, CiNii: 1390282681508695424)
71.	Yoshiko Yamamura, Katsumi Motegi, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Keiko Aota, Tomoko Yamanoi and Masayuki Azuma : TNF-a inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation., Journal of Cellular and Molecular Medicine, Vol.16, No.8, 1766-1775, 2012. (要約) Sjögren's syndrome is a systemic autoimmune disease characterized by reductions in salivary and lacrimal secretions. The mechanisms underlying these reductions remain unclear. We have previously shown that TNF-α plays an important role in the destruction of acinar structures. Here we examined TNF-α's function in the expression of aquaporin (AQP) 5 in human salivary gland acinar cells. Immortalized human salivary gland acinar (NS-SV-AC) cells were treated with TNF-α, and then the expression levels of AQP5 mRNA and protein were analysed. In addition, the mechanisms underlying the reduction of AQP5 expression by TNF-α treatment were investigated. TNF-α-treatment of NS-SV-AC cells significantly suppressed the expression levels of AQP5 mRNA and protein, and reduced the net fluid secretion rate. We examined the expression and activation levels of DNA methyltransferases (Dnmts) in NS-SV-AC cells treated with TNF-α. However, no significant changes were observed in the expression or activation levels of Dnmt1, Dnmt3a or Dnmt3b. Although we also investigated the role of NF-κB activity in the TNF-α-induced suppression of AQP5 expression in NS-SV-AC cells, we detected similar TNF-α suppression of AQP5 expression in non-transfected cells and in a super-repressor form of IκBα cDNA-transfected cell clones. However, interestingly, chromatin immunoprecipitation analysis demonstrated a remarkable decrease in levels of acetylated histone H4 associated with the AQP5 gene promoter after treatment with TNF-α in NS-SV-AC cells. Therefore, our results may indicate that TNF-α inhibition of AQP5 expression in human salivary gland acinar cells is due to the epigenetic mechanism by suppression of acetylation of histone H4. (キーワード) Acetylation / Acinar Cells / Aquaporin 5 / Chromatin / Fluorescent Antibody Technique / Gene Expression Regulation / Histones / Humans / Methyltransferases / NF-kappa B / Promoter Regions, Genetic / RNA, Messenger / 唾液腺 (salivary glands) / Tumor Necrosis Factor-alpha / Water (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1582-4934.2011.01456.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21973049 ● Summary page in Scopus @ Elsevier: 2-s2.0-84864383757 (DOI: 10.1111/j.1582-4934.2011.01456.x, PubMed: 21973049, Elsevier: Scopus)
72.	Yoshiko Yamamura, Keiko Aota, T Yamanoi, Kohichi Kani, H Takano, Yukihiro Momota, Katsumi Motegi and Masayuki Azuma : DNA demethylating agent decitabine increases AQP5 expression and restores salivary function., Journal of Dental Research, Vol.91, No.6, 612-617, 2012. (要約) Xerostomia is the symptom of oral dryness resulting most frequently, but not exclusively, from salivary gland hypofunction. Because the prevalence of xerostomia may increase with age, it has multiple oral health consequences in aging populations. In the present study, we demonstrate that the in vivo administration of 5-aza-2'-deoxycytidine (5-Aza-CdR; decitabine), a DNA demethylating agent, to the murine aging model C57BL/6CrSlc mice (24 wks old) increased the volumes of salivary flow compared with those of control mice. Western blot analysis and immunohistochemical staining demonstrated the augmented expression of AQP5 protein in the salivary glands of 5-Aza-CdR-treated mice compared with those of control mice. In addition, AQP5 protein expression levels in 5-Aza-CdR-treated old mice (27 wks old) were much higher than those in untreated and young mice (6 wks old). Global methylation levels in the salivary glands were significantly lower in the 5-Aza-CdR-treated mice than in the untreated mice. Moreover, the induction of demethylation in the AQP5 promoter of 5-Aza-CdR-treated mice was stronger than in the control mice. Analysis of our data therefore suggests that a DNA demethylating agent may be a useful drug for restoring hyposalivation in elderly individuals, thereby leading to the resolution of xerostomia. (キーワード) 加齢 (aging) / Animals / Aquaporin 5 / Azacitidine / Cell Membrane Permeability / DNA Methylation / DNA Modification Methylases / Female / Gene Expression Regulation / Mice / Mice, Inbred C57BL / Models, Animal / Promoter Regions, Genetic / Saliva / 唾液腺 (salivary glands) / Salivation / Specific Pathogen-Free Organisms / Xerostomia (出版サイトへのリンク) ● Publication site (DOI): 10.1177/0022034512446343 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22522773 ● Summary page in Scopus @ Elsevier: 2-s2.0-84860815326 (DOI: 10.1177/0022034512446343, PubMed: 22522773, Elsevier: Scopus)
73.	高野栄之, 桃田幸弘, 可児耕一, 松本文博, 茂木勝美, 青田桂子, 山村佳子, 大守真由子, 東雅之 : 副オトガイ孔を走行する神経様組織の捻除により口唇感覚異常が改善した症候性三叉神経痛の1例-神経学的検査の有用性について-, 日本口腔検査学会雑誌, Vol.4, No.1, 45-48, 2012年. (キーワード) accessory mental foramen / neurologic examination / lip paresthesia / symptomatic trigeminal neuralgia (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050282812688506368 (CiNii: 1050282812688506368)
74.	山村佳子, 桃田幸弘, 高野栄之, 可児耕一, 茂木勝美, 松本文博, 東雅之 : 真菌培養検査におけるカンジダの検出に影響する臨床的要因の検討ー口腔乾燥の関連についてー, 四国歯学会雑誌, Vol.24, No.2, 29-34, 2012年. (徳島大学機関リポジトリ) ● Metadata: 109812 (徳島大学機関リポジトリ: 109812)
75.	Tetsuya Tamatani, Masayuki Azuma, Katsumi Motegi, Natsumi Takamaru, Yuichiro Kawashima and Takashi Bando : Cepharanthin-enhanced radiosensitivity through the inhibition of radiation-induced nuclear factor-kappaB activity in human oral squamous cell carcinoma cells., International Journal of Oncology, Vol.31, No.4, 761-768, 2007. (要約) We have already demonstrated that human head and neck cancer cells have significantly enhanced levels of transcription factor nuclear factor (NF)-kappaB activity compared to their normal counterparts, suggesting that NF-kappaB plays an important role in the development of head and neck cancer. However, it has been reported that chemotherapeutic agents and radiation activate NF-kappaB activity in cancer cells, thus making the cells radioresistant and chemoresistant. In addition, we have shown that the suppression of NF-kappaB activity enhanced apoptosis in oral squamous cell carcinoma cells. In this study, we examined whether cepharanthin-induced inhibition of NF-kappaB activity enhances radiosensitivity in human oral carcinoma cells. Cepharanthin is a biscoclaurine alkaloid extracted from the roots of Stephania cepharantha hayata, and is widely used in Japan for the treatment of patients with leucopenia, nasal allergy, and venomous snakebites. gamma-irradiation (IR) induces NF-kappaB activity in oral carcinoma cells through the activation of upstream molecules, including Akt and IkappaB kinase. However, a luciferase assay revealed that cepharanthin suppresses IR-induced NF-kappaB activity in oral squamous cell carcinoma cells, thereby enhancing the radio-sensitivity. Western blot analysis showed an enhanced cleavage of poly-(ADP-ribose) polymerase protein in carcinoma cells by both cepharanthin treatment and IR exposure compared to IR or cepharanthin alone. In an in vivo study, B88 cells were s.c. inoculated into the backs of nude mice. Tumor-bearing nude mice received either cepharanthin, IR alone, or a combination of cepharanthin and IR. The combined treatment suppressed tumor growth significantly more than either cepharanthin or IR alone. Cepharanthin inhibited the production of IR-induced IL-6 and IL-8, which are downstream targets of NF-kappaB. In quantitative real-time RT-PCR, IR also induced the expression of anti-apoptotic proteins [cellular inhibitor of apoptosis protein (cIAP)-1 and -2] in carcinoma cells. Treatment of cancer cells with cepharanthin combined with exposure to IR decreased cIAP-1 and -2 mRNA expression. These findings suggested that the combination of radiotherapy and cepharanthin could enhance radiosensitivity in the treatment of human oral cancer. (キーワード) Alkaloids / Animals / Apoptosis / Benzylisoquinolines / Blotting, Western / Carcinoma, Squamous Cell / Cell Line, Tumor / Fluorescent Antibody Technique / Gamma Rays / Humans / I-kappa B Kinase / Inhibitor of Apoptosis Proteins / Interleukin-6 / Interleukin-8 / Luciferases / Mice / Mice, Inbred BALB C / Mice, Nude / Mouth Neoplasms / NF-kappa B / RNA, Messenger / Radiation, Ionizing / Radiation-Protective Agents (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17786306 ● Summary page in Scopus @ Elsevier: 2-s2.0-35848957914 (PubMed: 17786306, Elsevier: Scopus)
76.	Masayuki Azuma, Yuki Ashida, Tetsuya Tamatani, Katsumi Motegi, Natsumi Takamaru, Naozumi Ishimaru, Yoshio Hayashi and Mitsunobu Sato : Cepharanthin,a biscoclaurine alkaloid,prevents destruction of acinar tissues in murine Sjogren's syndrome., The Journal of Rheumatology, Vol.33, No.5, 912-920, 2006. (要約) Our previous study suggested that suppression by cepharanthin of tumor necrosis factor-a (TNF-a)-induced matrix metalloproteinase-9 (MMP-9) could prevent destruction of the acinar structure in the salivary glands of patients with Sjögren's syndrome (SS). In this study, we observed that in vivo administration of cepharanthin prevented severe damage to acinar tissues in the murine model of human SS. Cepharanthin was intraperitoneally administered to thymectomized female NFS/sld mice. Inflammatory lesions in the salivary and lacrimal glands were then examined histologically. Expression of phosphorylated IkB-a, MMP-9, and type IV collagen was analyzed immunohistochemically. The apoptotic cell death of acinar cells was determined. Although extensive mononuclear cell infiltration and destruction of acinar tissue in salivary and lacrimal glands were observed in control mice, significant improvement of these lesions was evident in mice treated with cepharanthin. Immunohistochemical analysis revealed that p65, phosphorylated IkB-a, and MMP-9 were more strongly stained in the acinar cells of control mice than in cepharanthin-treated mice. Although no staining for type IV collagen was observed in the acinar tissues of control mice, continuity of staining for type IV collagen was observed in acinar tissues of cepharanthin-treated mice. Destruction of acinar tissues was attributed to the induction of apoptosis, suggesting that cepharanthin inhibits apoptosis by suppressing phosphorylation of IkB-a, followed by prevention of MMP-9 activation. Our findings suggest that cepharanthin may be a promising agent for use in preventing destruction of acinar tissues in murine SS. (キーワード) Alkaloids / Animals / Apoptosis / Benzylisoquinolines / Carrier Proteins / Collagen Type IV / Female / I-kappa B Proteins / Immunohistochemistry / Lacrimal Apparatus / Matrix Metalloproteinase 9 / Mice / Mice, Mutant Strains / Neoplasm Proteins / Salivary Glands / Sjogren's Syndrome / Transcription Factor RelA (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16652422 ● Search Scopus @ Elsevier (PMID): 16652422 (PubMed: 16652422)
77.	玉谷哲也, 東雅之, 茂木勝美, 芦田有紀, 髙丸菜都美, 板東髙志, 吉田秀夫, 佐藤光信 : 口腔扁平上皮癌細胞に対するセファランチンによる放射線感受性増強作用 : 分子標的NF-κBの抑制, 日本口腔科学会雑誌, Vol.54, No.2, 230-236, 2005年. (キーワード) Cepharanthin / Radiosensitization / NF-κB (出版サイトへのリンク) ● Publication site (DOI): 10.11277/stomatology1952.54.230 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520290883462556800 ● Search Scopus @ Elsevier (DOI): 10.11277/stomatology1952.54.230 (DOI: 10.11277/stomatology1952.54.230, CiNii: 1520290883462556800)
78.	Katsumi Motegi, Masayuki Azuma, Tetsuya Tamatani, Yuki Ashida and Mitsunobu Sato : Expression of aquaporin-5 in and fluid secretion from immortalized human salivary gland ductal cells by treatment with 5-aza-2'-deoxycytidine: a possibility for improvement of xerostomia in patients with Sjögren's syndrome., Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.85, No.3, 342-353, 2005. (要約) The aim of the present study was to investigate the possibility that ductal cells, which preferentially survive and/or proliferate in Sjögren's syndrome (SS) salivary glands of patients with SS, could acquire the functional expression of membrane water channel aquaporin-5 (AQP5). Thus, in this study, we demonstrate that an immortalized normal human salivary gland ductal cell (NS-SV-DC) line, lacking the expression of AQP5, acquires AQP5 gene expression in response to treatment with 5-aza-2'-deoxycytidine (5-Aza-CdR), a DNA demethylating agent. Confocal microscopic analysis revealed the localization of AQP5 expression mainly at the apical and lateral sides of the plasma membrane. The expressed AQP5 protein was functionally active because AQP5 expression resulted in a significant increase in the osmotically directed net fluid rate across monolayers of NS-SV-DC cells. By the analysis of bisulfite sequencing of CpG islands in the AQP5 promoter, hypermethylation within the consensus Sp1-binding sites was commonly observed in parental cell clones, whereas demethylation at the CGs, one in the second consensus Sp1 element and the other outside of the third consensus Sp1 element in the AQP5 promoter, was detected in NS-SV-DC cells after treatment with 5-Aza-CdR. By analyzing the luciferase activity of transfected AQP5 promoter vectors, it became evident that demethylation at the CGs cooperatively functions between these two sites to induce AQP5 expression. Our data, therefore, suggest that treatment of ductal cells with 5-Aza-CdR could result in the expression of the AQP5 gene, thereby leading to increased fluid secretion from ductal cells in SS salivary glands. (キーワード) シェーグレン症候群 (Sjögren's syndrome) / アクアポリン5 / 唾液腺細胞 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/labinvest.3700234 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15640830 ● Summary page in Scopus @ Elsevier: 2-s2.0-14744285908 (DOI: 10.1038/labinvest.3700234, PubMed: 15640830, Elsevier: Scopus)
79.	Tetsuya Tamatani, Masayuki Azuma, Y Ashida, Katsumi Motegi, R Takashima, Koji Harada, S Kawaguchi and Mitsunobu Sato : Enhanced radiosensitization and chemosensitization in NF-κB-suppressed human oral cancer cells via the inhibition of g-irradiation- and 5-FU-induced production of IL-6 and IL-8, International Journal of Cancer, Vol.108, No.6, 912-921, 2004. (要約) We examined the mechanisms underlying the enhancement of radiosensitivity and chemosensitivity to gamma-irradiation (IR) and 5-Fluorouracil (5-FU) in human oral carcinoma cells (B88) in which NF-kappaB activity was constitutively suppressed. Three super-repressor form of IkappaBalpha cDNA-transfected cell (B88mI) clones and 1 empty vector-transfected cell clone (B88neo) have been established. We found that the tumor-forming ability in nude mice of B88mI clones was significantly lower than that of B88 or B88neo. This suppressed ability in tumorigenicity was attributed to the down-regulation of the expression of interleukin (IL)-1alpha, IL-6, IL-8, vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP)-9 in B88mI cell clones as compared to that in B88 or B88neo. IR and 5-FU induced a much greater degree of apoptosis, as evidenced by flow cytometry analysis and annexin V staining, in B88mI cell clones than in B88 or B88neo. When tumor-bearing nude mice were treated with IR or 5-FU, the suppression of tumor growth was significantly augmented in B88mI cell clones as compared to that in B88 or B88neo. ELISA analysis indicated that although a remarkable increase in production of IL-6 and IL-8 was observed in B88 and B88neo after in vitro exposure to IR or treatment with 5-FU, radiotherapy and chemotherapy-induced production of these cytokines was significantly suppressed in B88mI cell clones. These findings suggest that production of angiogenic factors and growth factors in response to radiotherapy and chemotherapy is a principal mechanism of inducible radioresistance and chemoresistance in human oral cancers, and establish the inhibition of NF-kappaB as a rational approach to improve conventional radiotherapy and chemotherapy outcomes. (キーワード) Animals / Annexin A5 / Antimetabolites, Antineoplastic / Apoptosis / Blotting, Western / Carcinoma / Cell Division / Cell Nucleus / Cell Separation / Culture Media, Conditioned / Cytosol / DNA, Complementary / Enzyme-Linked Immunosorbent Assay / Flow Cytometry / Fluorouracil / Gamma Rays / Genetic Vectors / Humans / I-kappa B Proteins / Immunohistochemistry / Interleukin-6 / Interleukin-8 / Luciferases / Matrix Metalloproteinase 9 / Mice / Mice, Nude / Mouth Neoplasms / Mutation / NF-kappa B / Neovascularization, Pathologic / Oligonucleotides / Time Factors / Transfection / Vascular Endothelial Growth Factor A (出版サイトへのリンク) ● Publication site (DOI): 10.1002/ijc.11640 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14712497 ● Search Scopus @ Elsevier (PMID): 14712497 ● Search Scopus @ Elsevier (DOI): 10.1002/ijc.11640 (DOI: 10.1002/ijc.11640, PubMed: 14712497)
80.	Mitsunobu Sato, Masayuki Azuma, Tetsuya Tamatani, Yuki Ashida, Rina Takashima and Koji Harada : Cisplatin induces apoptosis in oral squamous carcinoma cells by the mitochondria-mediated but not the NF-kB-suppressed pathway, Oral Oncology, Vol.39, No.3, 282-289, 2003. (要約) Cisplatin (CDDP) is a potent DNA-damaging anticancer agent, and its cytotoxic action is exerted by the induction of apoptosis. However, activation of the transcription factor NF-kappaB results in protection against apoptosis. We examined the molecular mechanisms involved in the induction of apoptosis by CDDP as regards both suppression of NF-kappaB and activation of caspases. Human oral squamous carcinoma cells (B88) were employed in this study. We found that CDDP treatment affected neither NF-kappaB activity nor the expression levels of antiapoptotic proteins, including TRAF-1, TRAF-2, and cFLIP, in B88 cells. However, two apoptosome molecules, cytochrome c and Apaf-1, were significantly augmented in the cytoplasm by CDDP treatment. Further, the activation of caspase-9 and caspase-3, downstream molecules leading to mitochondria-mediated apoptosis, were detected after treatment with CDDP. Finally, apoptosis was also clearly observed, as evidenced by cleavage of PARP through the activation of caspase-3. These findings suggest that CDDP exerts its apoptotic action by the mitochondria-mediated activation of caspases but not by the activation of caspases due to the inhibition of NF-kappaB activity that follows the suppression of antiapoptotic proteins. (キーワード) Antineoplastic Agents / Apoptosis / Carcinoma, Squamous Cell / Caspases / Cell Division / Cisplatin / Cytochrome c Group / Dose-Response Relationship, Drug / Humans / Mitochondria / Mouth Neoplasms / NF-kappa B / Receptors, Tumor Necrosis Factor / Reverse Transcriptase Polymerase Chain Reaction / Tumor Cells, Cultured (出版サイトへのリンク) ● Publication site (DOI): 10.1016/S1368-8375(02)00116-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12618201 ● Search Scopus @ Elsevier (PMID): 12618201 ● Search Scopus @ Elsevier (DOI): 10.1016/S1368-8375(02)00116-1 (DOI: 10.1016/S1368-8375(02)00116-1, PubMed: 12618201)
81.	Masayuki Azuma, Keiko Aota, Tetsuya Tamatani, Katsumi Motegi, Yuki Ashida, Yoshio Hayashi, Mitsunobu Sato and Mitsunobu Sato : Suppression of TNF-α-induced MMP 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of NFκB, --- A possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjögren's syndrome patients ---, Arthritis and Rheumatism, Vol.46, No.6, 1585-1594, 2002. (要約) Our previous results suggested that suppression of tumor necrosis factor alpha (TNFalpha)-induced matrix metalloproteinase 9 (MMP-9) could prevent the destruction of acinar tissue in the salivary glands of patients with Sjögren's syndrome (SS). The present study was undertaken to investigate the effect of cepharanthine on the suppression of TNFalpha-induced MMP-9 production in NS-SV-AC, an SV40-immortalized normal human acinar cell clone. After pretreatment with or without cepharanthine, NS-SV-AC cells were treated with TNFalpha alone or with a combination of TNFalpha and cepharanthine. The expression of MMP-9 was then examined at the protein and messenger RNA levels. In addition, the effect of cepharanthine on the morphogenetic behavior of NS-SV-AC cells cultured on type IV collagen-coated dishes in the presence of TNFalpha was examined. Although TNFalpha induced the production of MMP-9 in NS-SV-AC cells, this production was greatly suppressed when cells were pretreated with cepharanthine, followed by treatment with both TNFalpha and cepharanthine. In addition, cepharanthine suppressed the TNFalpha-stimulated NF-kappaB activity by partly preventing the degradation of IkappaBalpha protein in NS-SV-AC cells. When NS-SV-AC cells were seeded on type IV collagen-coated dishes in the presence of both TNFalpha and plasmin, type IV collagen interaction with the cells was lost and the cells entered apoptosis. However, pretreatment with cepharanthine restored the aberrant in vitro morphogenesis of the NS-SV-AC cells. These results may indicate a molecular mechanism by which cepharanthine is able to protect against the destruction of the acinar structure in salivary glands from patients with SS. (キーワード) Alkaloids / Anti-Inflammatory Agents, Non-Steroidal / Antibodies / Benzylisoquinolines / Cell Division / Cells, Cultured / Collagen Type II / DNA-Binding Proteins / Down-Regulation / Enzyme Activation / Gene Expression Regulation, Enzymologic / Humans / I-kappa B Proteins / Matrix Metalloproteinase 9 / NF-kappa B / Promoter Regions, Genetic / RNA, Messenger / Salivary Glands / Tumor Necrosis Factor-alpha (出版サイトへのリンク) ● Publication site (DOI): 10.1002/art.10315 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 12115190 ● Search Scopus @ Elsevier (PMID): 12115190 ● Search Scopus @ Elsevier (DOI): 10.1002/art.10315 (DOI: 10.1002/art.10315, PubMed: 12115190)
82.	Mitsunobu Sato, Keiko Aota, Masayuki Azuma, Tetsuya Tamatani, Tuyoshi Yamashita and Yuki Ashida : Stable inhibition of NF-kB in salivary gland cells does not enhance sensitivity to TNF-a-induced apoptosis due to upregulation of TRAF-1 expression, Experimental Cell Research, Vol.276, No.1, 111-119, 2002. (要約) The transcription factor NF-kappa B inhibits the apoptotic response induced by TNF-alpha. However, in salivary gland cell clones (ACMT-6 and ACMT-7) in which NF-kappa B activation was suppressed by introduction of a super-repressor form of I kappa B-alpha cDNA, TNF-alpha did not cause apoptosis. Thus, to investigate the molecular mechanism involved in the unresponsiveness of these cell clones to TNF-alpha-induced apoptosis, we examined the effect of TNF-alpha on the expression of antiapoptotic proteins, including TNF receptor-associated factor (TRAF)-1, TRAF-2, cellular inhibitor of apoptosis protein (cIAP)-1, and cIAP-2. Here we show that expression of TRAF-1 was commonly detected by treatment with TNF-alpha in ACMT-6, ACMT-7, and an empty vector-transfected cell clone (ACpRc-1) and that downregulation of TRAF-1 protein by either treatment with an antisense oligonucleotide or introduction of an antisense plasmid resulted in the induction of apoptosis in these cell clones. Our results, therefore, suggest that one of the mechanisms by which cells acquire resistance to TNF-alpha-induced apoptosis is a TNF-alpha induction of TRAF-1. (キーワード) Apoptosis / Cell Division / Cell Line, Transformed / Clone Cells / Humans / NF-kappa B / Oligonucleotides, Antisense / Protein Biosynthesis / Proteins / RNA, Messenger / Salivary Glands / TNF Receptor-Associated Factor 1 / Transcriptional Activation / Transfection / Tumor Necrosis Factor-alpha / Up-Regulation (出版サイトへのリンク) ● Publication site (DOI): 10.1006/excr.2002.5515 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11978013 ● Search Scopus @ Elsevier (PMID): 11978013 ● Search Scopus @ Elsevier (DOI): 10.1006/excr.2002.5515 (DOI: 10.1006/excr.2002.5515, PubMed: 11978013)
83.	Tetsuya Tamatani, Masayuki Azuma, Aota K, Yamashita T, Takashi Bando and Mitsunobu Sato : Enhanced IkB kinase activity is responsible for the augmented activity of NF-_B in human head and neck carcinoma cells, Cancer Letters, Vol.171, No.2, 165-172, 2001. (要約) The nuclear transcription factor kappaB (NF-kappaB) plays an important role in the development and progression of cancers. However, the mechanism by which cancer cells in the head and neck region acquire high NF-kappaB activity has not yet been clarified. In this study, we examined the NF-kappaB binding activity and the expression of the signal-transduction-related proteins of NF-kappaB in head and neck carcinoma cell lines. These cancer cells showed significantly higher NF-kappaB binding activity than normal oral epithelial and salivary gland cells. We also demonstrated the increased phosphorylation and degradation of IkappaB-alpha protein in cancer cells. Thus, enhanced NF-kappaB activity in cancer cells is attributable to the rapid phosphorylation and degradation of IkappaB-alpha protein. To further elucidate the mechanism involved in this phenomenon, we analyzed both the expression levels of upstream kinases (IkappaB kinase- (IKK-) alpha, IKK-beta, IKK-gamma, and NF-kappaB-inducing kinase (NIK)) and the IKK activity in cells. Although there was no significant difference in the expression levels of NIK, IKK-beta, or IKK-gamma in cancer cell lines compared to those in normal cells, increased expression of IKK-alpha protein was observed in cancer cells. In addition, IKK activity was significantly augmented in cancer cells as compared to normal cells. Thus, our results suggest that enhanced NF-kappaB activity in head and neck cancer cells may be due to the augmentation of IKK activity. (キーワード) Carcinoma, Squamous Cell / Head and Neck Neoplasms / Humans / I-kappa B Kinase / Isoenzymes / NF-kappa B / NF-kappa B p50 Subunit / Phosphorylation / Protein Binding / Protein-Serine-Threonine Kinases / RNA, Messenger / Reverse Transcriptase Polymerase Chain Reaction / Transcription Factor RelA / Tumor Cells, Cultured (出版サイトへのリンク) ● Publication site (DOI): 10.1016/S0304-3835(01)00611-5 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11520600 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035840790 (DOI: 10.1016/S0304-3835(01)00611-5, PubMed: 11520600, Elsevier: Scopus)
84.	玉谷哲也, 東雅之, 吉田秀夫, 佐藤光信 : 口腔癌細胞への変異型IkB-a遺伝子導入による抗血管新生作用を介した腫瘍増殖抑制効果, 口腔組織培養学会誌, Vol.10, No.2, 45-54, 2001年.
85.	Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Norio Haneji, Mizuho Nishino, Masayuki Azuma, Ichiro Saito and Yoshio Hayashi : Autoantigen-specific CD4+CD28low T cell subset prevents autoimmune exocrinopathy in murine Sjogren's syndrome, The Journal of Immunology, Vol.165, No.4, 2251-2257, 2000. (要約) Organ-specific autoimmune exocrinopathy resembling Sjögren's syndrome (SS) that spontaneously develops in NFS/sld mutant mice thymectomized 3 day after birth is dependent on Th1-type CD4+ T cells. We previously reported that a cleavage product of 120-kDa alpha-fodrin may be an important autoantigen in the pathogenesis of SS in both an animal model and the patients. We demonstrate that in an animal model of SS with overt exocrinopathy, a unique CD4+ T cell subset expressing CD28low is dramatically increased in spleen cells before the disease onset, but that the CD4+ T cells of diseased mice were virtually all CD28high. We found that the spleen cells in these mice before the disease onset showed a significant increase in autoantigen-specific T cell proliferation. Analysis of in vitro cytokine production by spleen cells indicated, before the disease onset, severely impaired production of IL-2 and IFN-gamma in the animal model, whereas high levels of IL-4 were observed. Expression of cytokine genes, including IL-4, IL-10, and TGF-beta, was detected in FACS-sorted CD4+CD28low T cells by RT-PCR analysis. Transfer of CD4+CD28low T cells into the animal model actually prevented the development of autoimmune lesions including autoantibody production. These results suggest that a CD4+CD28low T cell subset that is continuously activated by an organ-specific autoantigen may play a regulatory role in the development of organ-specific autoimmune disease in an animal model of SS. (キーワード) Adoptive Transfer / Animals / Autoantigens / CD28 Antigens / CD4-Positive T-Lymphocytes / Carrier Proteins / Cells, Cultured / Epitopes, T-Lymphocyte / Female / Flow Cytometry / Injections, Intraperitoneal / Lymphocyte Activation / Mice / Mice, Inbred BALB C / Mice, Inbred C57BL / Mice, Mutant Strains / Microfilament Proteins / Sjogren's Syndrome / T-Lymphocyte Subsets (出版サイトへのリンク) ● Publication site (DOI): 10.4049/jimmunol.165.4.2251 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10925313 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034664060 (DOI: 10.4049/jimmunol.165.4.2251, PubMed: 10925313, Elsevier: Scopus)
86.	Masayuki Azuma, Tetsuya Tamatani, Katsumi Motegi, Keiko Aota, Tsuyoshi Yamashita, Kouji Harada, Yoshio Hayashi and Mitsunobu Sato : Suppression of tumor necrosis factor-a-induced matrix metalloproteinase-9-production by introduction of a super-repressor form of IkB-cDNA into immotalized human salivary gland acinar cells, Arthritis and Rheumatism, Vol.43, No.8, 1756-1767, 2000. (要約) We have previously shown that specific enhancement in acinar cells of proteolytic activity induced by tumor necrosis factor alpha (TNFalpha) may be responsible for the destruction of the acinar structure in the salivary glands of patients with Sjögren's syndrome. Because matrix metalloproteinase 9 (MMP-9) is regulated by nuclear factor kappaB (NF-kappaB), we investigated the effect of a super-repressor form of inhibitor of nuclear factor kappaBalpha (srIkappaBalpha) on the suppression of TNFalpha-induced MMP-9 production in acinar cells. Two srIkappaBalpha complementary DNA (cDNA)-transfected acinar cell clones (ACMT-6 and ACMT-7) and 1 empty vector-transfected cell clone (ACpRc-1) were established. After treatment of cell clones with TNFalpha, the expression of MMP-9 was examined. In addition, the effect of TNFalpha on cell growth and the morphogenetic behavior of cell clones cultured on type IV collagen-coated dishes were examined. TNFalpha induced the production of MMP-9 in the ACpRc-1 cell clone, but greatly suppressed MMP-9 production in ACMT-6 and ACMT-7 clones. No apparent cytotoxic effect of TNFalpha treatment was observed in these cell clones. When ACpRc-1 cells were seeded on type IV collagen-coated dishes in the presence of both TNFalpha and plasmin, type IV collagen interaction with the cells was lost and the cells entered apoptosis. However, even when ACMT-6 and ACMT-7 cells were cultured under the same culture conditions as those for ACpRc-1, these cell clones attached to the substrate and grew consistently without showing apoptosis. Conclusion. These observations indicate that suppression of TNFalpha-induced MMP-9 production by the introduction of srIkappaBalpha cDNA corrected the aberrant in vitro morphogenesis of acinar cells grown on type IV collagen. (キーワード) Blotting, Western / Cell Division / Clone Cells / Collagen / Culture Media / DNA, Complementary / Fibrinolysin / Gene Expression / Humans / Immunohistochemistry / Matrix Metalloproteinase 9 / NF-kappa B / RNA, Messenger / Salivary Glands / Tissue Inhibitor of Metalloproteinase-1 / Tumor Necrosis Factor-alpha (出版サイトへのリンク) ● Publication site (DOI): 10.1002/1529-0131(200008)43:8<1756::AID-ANR12>3.0.CO;2-H (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10943866 ● Summary page in Scopus @ Elsevier: 2-s2.0-0033892746 (DOI: 10.1002/1529-0131(200008)43:8<1756::AID-ANR12>3.0.CO;2-H, PubMed: 10943866, Elsevier: Scopus)
87.	Keiko Aota, Masayuki Azuma, Tsuyoshi Yamashita, Testuya Tamatani, Katsumi Motegi, Naozumi Ishimaru, Yoshio Hayashi and Mitsunobu Sato : 5-Fluorouracil Induces Apoptosis through the Suppression of NF-κB Activity in Human Salivary Gland Cancer Cells, Biochemical and Biophysical Research Communications, Vol.273, No.3, 1168-1174, 2000. (要約) Activation of the transcription factor NF-kappaB results in protection against apoptosis, and the chemotherapeutic agent 5-Fluorouracil (5-FU) exerts its cytotoxic effect through the induction of apoptosis. Thus, we examined whether 5-FU could induce apoptosis through the suppression of NF-kappaB activity. We found that upon treatment of a human salivary gland cancer cell line (cl-1) with 5-FU, the NF-kappaB activity was suppressed in a time-dependent manner. This inhibition was mediated by a prevention of the degradation of the inhibitory IkappaB-alpha protein. In addition, the expression of TRAF-2 and cIAP-1, which are transcriptionally regulated by NF-kappaB and function as anti-apoptotic molecules through the interruption of caspase pathway, was also inhibited by 5-FU. Finally, the activity of caspase-8 and caspase-3 showed a significant increase in response to 5-FU. By flow cytometric analysis, 5-FU did not affect the expression level of Fas on the cell surface. Thus, our results suggest that one of the molecular mechanisms involved in 5-FU-induced apoptosis in cl-1 cells may be due to the suppression of NF-kappaB activity, resulting in the activation of the pro-apoptotic pathway. (キーワード) NF-κB / IκB-α / salivary gland cancer cells / 5-FU / アポトーシス (apoptosis) / TRAF-2 / cIAP-1 / Fas / caspase-8 / caspase-3 (出版サイトへのリンク) ● Publication site (DOI): 10.1006/bbrc.2000.3072 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10891390 ● Search Scopus @ Elsevier (PMID): 10891390 ● Search Scopus @ Elsevier (DOI): 10.1006/bbrc.2000.3072 (DOI: 10.1006/bbrc.2000.3072, PubMed: 10891390)
88.	Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagi, Norio Haneji, Mizuho Nishino, Masayuki Azuma and Yoshio Hayashi : Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome (SS) through up-regulated Th2 response, Clinical and Experimental Immunology, Vol.119, No.2, 354-360, 2000. (キーワード) CD86 costimulation / Preventive Effect / α-Fodrin / Autoantigen / Th2 Cytokine / Sjogren's Syndrome
89.	Kaoru Saegusa, Naozumi Ishimaru, Kumiko Yanagai, Norio Haneji, Mizuho Nishino, Masayuki Azuma, Ichiro Saito and Yoshio Hayashi : Treatment with anti-CD 86 costimulatory molecule prevents the autoimmune lesions in murine Sjogren's syndrome(SS) through up-regulated Th2 response, Clinical and Experimental Immunology, Vol.119, 354-360, 2000.
90.	柳久美子, 東雅之, 佐藤光信, 林良夫 : 慢性GVHDにおける口腔粘膜·口唇腺の免疫組織化学的研究, 日本口腔粘膜学会雑誌, Vol.6, 62-68, 2000年.
91.	Masayuki Azuma, Katsumi Motegi, Keiko Aota, Yoshio Hayashi and Mitsunobu Sato : Role of cytokines in the destruction of acinar structure in Sjogren's syndrome salivary glands, Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.77, No.3, 269-280, 1997.
92.	Mitsunobu Sato, Koji Harada, Hideo Yoshida, Yura Yoshiaki, Masayuki Azuma, Hiroki Iga, Takashi Bando, Kawamata Hitoshi and Yoshihiro Takegawa : Therapy for oral squamous cell carcinoma by tegafur and streptococcal agent OK-432 in combination with radiotherapy : Association of the therapeutic effect with differentiation and apoptosis in the cancer cells, Apoptosis, Vol.2, No.2, 227-238, 1997. (要約) Twenty patients with oral squamous cell carcinoma having mainly stage II or III lesions without distant metastasis, were treated with tegafur and streptococcal agent, OK-432, in combination with radiotherapy. As a consequence, 16 cases among the treated 20 cases showed complete remission by this therapy alone. Especially, we have found that the squamous cell carcinoma arising in non-keratinizing oral epithelium rather than in keratinizing oral epithelium has better response to this therapy. Among the 16 cases with complete remission (CR) by the current therapy, 10 cases were histopathologically diagnosed as well-differentiated squamous cell carcinoma and six cases as moderately differentiated squamous cell carcinoma. When we examined immunohistochemically the expression of various antigens such as proliferating cell nuclear antigen (PCNA), p53 and LeY or the presence of DNA fragmentation by nick-end labelling in the biopsy materials taken at the first visit to our clinic from 20 patients treated with the current therapy, the CR group showed a significantly increased LeY expres-sion level ( p< 0.05) and DNA fragmentation rate (p< 0.05) as compared with the partial response (PR, n= 3) + no change (NC, n= 1) group. On the other hand, the CR group with respect to PCNA expression level was significantly decreased as compared with the PR + NC group ( p< 0.05). From these findings, it can be considered that the therapy for oral squamous cell carcinoma by UFT and OK-432 in combination with radiotherapy is very effective, which may be associated with differentiation or apoptosis in oral squamous carcinoma cells. In addition, we present the clinical findings and results of immunohistochemical staining for the biopsy materials obtained from four CR cases treated with the current therapeutic method. (出版サイトへのリンク) ● Publication site (DOI): 10.1023/a:1026428918301 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 14646559 ● Summary page in Scopus @ Elsevier: 2-s2.0-0001412157 (DOI: 10.1023/a:1026428918301, PubMed: 14646559, Elsevier: Scopus)
93.	Masayuki Azuma, Katsumi Motegi, Keiko Aota, Yoshio Hayashi and Mitsunobu Sato : Role of cytokines of acinar structure in Sjogren's syndrome salivary glands, Laboratory Investigation; a Journal of Technical Methods and Pathology, Vol.77, No.3, 269-280, 1997.
94.	Yoshio Hayashi, Tetsuo Yanagawa, Hideo Yoshida, Masayuki Azuma, Toshinobu Nishida, Yoshiaki Yura and Mitsunobu Sato : Expression of vasoactive intestinal polypeptide and amylase in a human parotid gland adenocarcinoma cell line in culture, Journal of the National Cancer Institute, Vol.79, No.5, 1025-1037, 1987.
95.	Yoshio Hayashi, Shinichi Nagamine, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura, Masayuki Azuma and Mitsunobu Sato : Small cell undifferentiated carcinoma of the minor salivary gland containing exocrine, neuroendocrine, and squamous cells, Cancer, Vol.60, No.7, 1583-1588, 1987.
96.	Yoshio Hayashi, Hideo Yoshida, Shinichi Nagamine, Tetsuo Yanagawa, Yoshiaki Yura, Masayuki Azuma and Mitsunobu Sato : Induction of cells with acinar cell phenotype including presence of intracellular amylase, --- Treatment with 12-O-tetradecanoyl-phorbol-13-acetate in a neoplastic human salivary intercalated duct cell line grown in athymic nude mice ---, Cancer, Vol.60, No.5, 1000-1008, 1987.
97.	Masayuki Azuma, Furumoto Nanayo, Kawamata Hitoshi, Hideo Yoshida, Yanagawa Tetsushi, Yura Yoshiaki, Yoshio Hayashi, Yoshihiro Takegawa and Mitsunobu Sato : The relation of ras oncogene product p21 expression to clinocopathological status criteria and clinical outcome in squamous cell head and neck cancer, The Cancer Journal, Vol.1, No.9, 375-380, 1987.
98.	Masayuki Azuma, Yoshio Hayashi, Hideo Yoshida, Tetsuo Yanagawa, Yoshiaki Yura, Akemichi Ueno and Mitsunobu Sato : Emergence of differentiated subclones from a human salivary adenocarcinoma cell clone in culture after treatment with sodium butyrate, Cancer Research, Vol.46, No.2, 770-777, 1986.
99.	Mitsunobu Sato, Hideo Yoshida, Yoshio Hayashi, Kenji Miyakami, Takashi Bando, Tetsuo Yanagawa, Yura Yura, Masayuki Azuma and Akemichi Ueno : Expression of epidermal growth factor and transforming growth factor-beta in human salivary gland adenocarcinoma cell line, Cancer Research, Vol.45, No.12 P 1, 6160-6167, 1985.
100.	Mitsunobu Sato, Yoshio Hayashi, Tetsuo Yanagawa, Hideo Yoshida, Yoshiaki Yura, Masayuki Azuma and Akemichi Ueno : Intermediate-sized filaments and specific markers in a human salivary gland adenocarcinoma cell line and its nude mouse tumors, Cancer Research, Vol.45, No.8, 3837-3790, 1985.
101.	Mitsunobu Sato, Hideo Yoshida, Yanagawa Tetsuo, Yura Yoshiaki, Urata Mitsuru, Masayuki Azuma, Furumoto Nanayo, Yoshio Hayashi and Yoshihiro Takegawa : Interferon Activity and Its Characterization in the Sera of Patients with Head and Neck Cancer, Cancer, Vol.54, No.1, 1239-1251, 1984. (文献検索サイトへのリンク) ● Summary page in Scopus @ Elsevier: 2-s2.0-0021170090 (Elsevier: Scopus)

学術論文(紀要・その他):

1.	山ノ井朋子, 青田桂子, 東雅之 : ヒト唾液腺細胞におけるピロカルピン塩酸塩の AQP5 発現に関する研究, 口腔組織培養学会誌, Vol.28, No.1, 21-22, 2019年.
2.	高野栄之, 桃田幸弘, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二, 金川裕子, 東雅之 : 徳島大学病院口腔内科-発足前後5年間における外来・入院患者の臨床統計的観察-, 日本口腔内科学会雑誌, Vol.22, No.1, 59, 2016年.

学術レター:

1.	佐藤光信, 吉田秀夫, 由良義明, 東雅之, 伊賀弘起, 加地亮詞, 板東高志, 梁川哲雄, 竹川佳宏 : 口腔扁平上皮癌に対するUFT,OK-432, 放射線治療を併用した一次治療, BIOTHERAPY, Vol.6, No.1, 108-111, 1992年.

総説・解説:

1.	桃田幸弘, 東雅之 : 口内炎の予防と体質改善-口内炎を治療してきた歯科医の提言-, 徳島大大学開放実践センター紀要, Vol.28, 49-53, 2019年3月. (徳島大学機関リポジトリ) ● Metadata: 113513 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050845763756941440 (徳島大学機関リポジトリ: 113513, CiNii: 1050845763756941440)
2.	高石和美, 藤原茂樹, 江口覚, 大塚良, 赤澤友基, 北村尚正, 上田(山口) 公子, 中川弘, 可児耕一, 青田桂子, 桃田幸弘, 山村佳子, 工藤景子, 大江剛, 玉谷哲也, 宮本洋二, 東雅之, 岩本勉, 北畑洋 : 当院における全身麻酔下歯科治療について -障害をもつ方へ安全な歯科治療の提供-, Journal of Oral Health and Biosciences, Vol.31, No.1, 62-67, 2018年7月. (要約) We report about general anesthesia for disabled patients with special needs or young children during dental treatment in Tokushima University Hospital. We have administered ambulatory anesthesia or general anesthesia with short-term hospitalization for the patients. In this report, we showed anesthesia as a behavior management technique and the system for the patients who schedule ambulatory anesthesia in our hospital. We indicated the present situation of dental treatment under general anesthesia and supposed the prospects of dental care for the patients with special needs. (キーワード) 全身麻酔 / 障害者 / 日帰り全身麻酔 / 歯科治療 (徳島大学機関リポジトリ) ● Metadata: 111940 (出版サイトへのリンク) ● Publication site (DOI): 10.20738/johb.31.1_62 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390845712973457920 ● Search Scopus @ Elsevier (DOI): 10.20738/johb.31.1_62 (徳島大学機関リポジトリ: 111940, DOI: 10.20738/johb.31.1_62, CiNii: 1390845712973457920)
3.	桃田幸弘, 高野栄之, 東雅之 : 舌痛症の診断を再考する, 徳島大学大学開放実践センター紀要, Vol.27, 41-46, 2018年3月. (徳島大学機関リポジトリ) ● Metadata: 112229 (徳島大学機関リポジトリ: 112229)
4.	可児耕一, 桃田幸弘, 青田桂子, 東雅之 : 口腔扁平上皮癌に対するNF-κBを分子標的とした新規併用癌化学療法の開発, BIO Clinica, Vol.33, No.2, 74-79, 2018年2月.
5.	桃田幸弘, 東雅之, 小林真之 : 歯科領域の漢方概説-難治性疾患に対する漢方薬の効用-, 歯科薬物療法, Vol.37, No.3, in-press, 2018年.
6.	桃田幸弘, 東雅之 : 口の痛みについて-口腔顔面痛とその随伴症状-, 徳島大学大学開放実践センター紀要, Vol.26, 57-66, 2017年. (徳島大学機関リポジトリ) ● Metadata: 112225 (徳島大学機関リポジトリ: 112225)
7.	青田桂子, 東雅之 : HIV感染症/AIDSによる口腔カンジダ症, デンタルハイジーン, Vol.35, No.6, 637-639, 2015年6月.
8.	桃田幸弘, 東雅之 : 歯科用金属によるアレルギー, デンタルハイジーン, Vol.35, No.5, 513-5, 2015年5月.
9.	桃田幸弘, 高野栄之, 東雅之 : 貧血による舌炎, デンタルハイジーン, Vol.35, No.4, 357-9, 2015年4月.
10.	東雅之, 山村佳子 : くすり&全身疾患㈭ヘルパンギーナ, デンタルハイジーン, Vol.35, No.8, 869-871, 2015年.
11.	桃田幸弘, 東雅之 : 臓器移植後の歯科治療, 月刊「歯界展望」別冊歯科医師のための医学ハンドブック, 192-193, 2014年5月.
12.	東雅之 : シェーグレン症候群に対する病期対応型テーラーメード医療の構築, 四国歯学会雑誌, Vol.23, No.2, 85-89, 2011年2月. (キーワード) シェーグレン症候群 (Sjögren's syndrome) (徳島大学機関リポジトリ) ● Metadata: 109802 (徳島大学機関リポジトリ: 109802)
13.	桃田幸弘, 東雅之 : 舌痛を訴える患者について考える, 四国歯学会雑誌, Vol.23, No.2, 133-137, 2011年. (徳島大学機関リポジトリ) ● Metadata: 109807 (徳島大学機関リポジトリ: 109807)

国際会議:

1.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, N Takase, Hiroko Kanagawa, Tomoko Yamanoi, Yuki Miyamoto, Shigemasa Tomioka and Masayuki Azuma : Intractable Stomatitis Well-Treated with Kampo Medicines: A Case Series, The 13th Asian Congress on Oral and Maxillofacial Surgery, Taipei, Nov. 2018.
2.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, 高瀬奈緒, 宮本由貴, Shinji Ono and Masayuki Azuma : A Case Series of Xerostomia Treated with Kampo Medicines: Assessment of Health-Related Quality of Life Based on the Japanese Version of the Short Form-8 Health Survey, 23rd International Conference on Oral and Maxillofacial Surgery, Hong Kong, Mar. 2017. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijom.2017.02.1247 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijom.2017.02.1247 (DOI: 10.1016/j.ijom.2017.02.1247)
3.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Fumihiro Matsumoto, Keiko Aota, Tomoko Yamanoi, Nao Takase, Yuki Miyamoto, Shinji Ono and Masayuki Azuma : Orofacial Pain Well-Treated with Concomitant Pregabalin, Tramadol Hydrochloride, Acetaminophen, and Powdered Processed Aconite Roots: A Case Series, International Congress on Orofacial Pain, Yokohama, Sep. 2016.
4.	Minami Sato, Kumiko Nagata, Shingo Kuroda, MANSJUR KARIMA QURNIA, Shinya Horiuchi, Yoshiko Yamamura, Masayuki Azuma and Eiji Tanaka : Effects of low-intensity pulsed ultrasound on salivary gland, The 3rd ASEAN Plus and Tokushima Joint International Conference, Makassar, Indonesia., Dec. 2014.
5.	Yukihiro Momota, Kohichi Kani, Hideyuki Takano, Fumihiro Matsumoto, Katsumi Motegi, Keiko Aota, Yoshiko Yamamura and Masayuki Azuma : Clinical significance of time-domain analysis of heart rate variability in burning mouth syndrome, 96th Annual Meeting Scientific Sessions & Exhibition, Hawaii, Sep. 2014.
6.	Yoshiko Yamamura, Katsumi Motegi, Yukihiro Momota, Keiko Aota, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : A mechanism underlying the constitutive expression of AQP5 in human salivary gland acinar cells, 21st International canference on oral and maxillofacial surgery, Barcelona, Oct. 2013.
7.	Keiko Aota, Yoshiko Yamamura, Mayuko Omori and Masayuki Azuma : Effectiveness of professional oral care for the improvement of oral hygiene in patients with psychiatry neurology., Asean Plus and Tokushima Joint International Conference, Indonesia, Dec. 2012.
8.	Yoshiko Yamamura, Katsumi Motegi, Keiko Aota, Tomoko Yamanoi, Yukihiro Momota and Masayuki Azuma : Mechanism involved in the constitutive expression of AQP5 in human salivary gland acinar cells., Asean Plus and Tokushima Joint International Conference, Indnesia, Dec. 2012.
9.	Yukihiro Momota, Hideyuki Takano, Kohichi Kani, Yoshiko Yamamura and Masayuki Azuma : Frequency analysis of heart rate variability: a useful assessment tool of linearly polarized near-infrared irradiation to stellate ganglion area for burning mouth syndrome., 10th Asian Congress on Oral and Maxillofacial Surgeons, Bali, Nov. 2012.
10.	Yoshiko Yamamura, Keiko Aota, Katsumi Motegi, T Yamanoi, Yukihiro Momota, Hideyuki Takano, Kohichi Kani and Masayuki Azuma : Augmented Expression of Aquaporin 5 in Aging Mice, The 2nd International Joint Symposium on Oral and Dental Sciences in Conjunction with Dental Specialists Seminar, Indonesia, Mar. 2012.
11.	Masayuki Azuma : Functional Regeneration of Salivary Gland, The 2nd International Joint Symposium on Oral and Dental Sciences, Yogyakarta, Mar. 2012.
12.	Masayuki Azuma, Katsumi Motegi, Yoshiko Yamamura, Kohichi Kani, Hideyuki Takano, Yukihiro Momota, Keiko Aota and T Yamanoi : TNF-a inhibits aquaporin 5 expression in human salivary gland acinar cells via suppression of histone H4 acetylation., Autoimmunity Congress Asia, Vol.1, No.1, 1-5, Singapore, Nov. 2011.

国内講演発表:

1.	青田桂子, 可児耕一, 桃田幸弘, 石丸直澄, 東雅之 : シェーグレン症候群唾液腺におけるJAKsの発現解析, 第76回日本口腔科学会学術集会, 2022年4月. (キーワード) シェーグレン症候群 (Sjögren's syndrome) / JAK
2.	青田桂子, 可児耕一, 桃田幸弘, 石丸直澄, 東雅之 : シェーグレン症候群唾液腺におけるJAK1およびJAK2の発現解析, 第66回日本口腔外科学会学術集会, 2021年11月.
3.	青田桂子, 山ノ井朋子, 可児耕一, 桃田幸弘, 東雅之 : シェーグレン症候群新規治療薬としてのJAK阻害薬の可能性, 第75回日本口腔科学会学術集会, 2021年5月.
4.	大山博行, 青田桂子, 中原崇道, 山ノ井朋子, 可児耕一, 桃田幸弘, 松本文博, 東雅之 : Fontan術後患者に対して埋伏智歯抜歯を施行した1例, 第49回日本口腔外科学会中国四国支部学術集会, 2021年2月.
5.	桃田幸弘, 高野栄之, 可児耕一, 小野信二, 東雅之 : 葛根湯が奏効した特発性first bite syndromeの1例, 第25回日本口腔顔面痛学会, 2020年11月.
6.	桃田幸弘, 可児耕一, 高野栄之, 小野信二, 青田桂子, 松本文博, 山ノ井朋子, 中原崇道, 大山博行, 金川裕子, 東雅之 : 当科における直接経口抗凝固薬投与下の観血的処置の現状分析, 第30回日本口腔内科学会学術集会, 2020年11月.
7.	青田桂子, 山ノ井朋子, 可児耕一, 東雅之 : JAK阻害薬バリシチニブは唾液腺細胞のIFN-γ誘導性CXCL10を抑制する, 第65回日本口腔外科学会・学術集会, 2020年11月.
8.	高野栄之, 桃田幸弘, 可児耕一, 宮本悦子, 東山祐陽, 西英光, 飛梅悟, 郡由紀子, 河野美枝子, 東雅之 : 第4回バリフリBOX における摂食嚥下等に関するアンケート調査, 第17回日本口腔ケア学会, 2020年9月.
9.	青田桂子, 山ノ井朋子, 可児耕一, 桃田幸弘, 東雅之 : シェーグレン症候群唾液腺でのMMP-9過剰発現機序とCXCL10への関与, 第74回日本口腔科学会学術集会, 2020年4月.
10.	河原林啓太, 加納史也, 橋本登, 寺町順平, 青田桂子, 東雅之, 岩本勉, 山本朗仁 : 歯髄幹細胞由来無血清培養上清を用いた口腔乾燥症の治療法の開発, 徳島県歯科医学大会, 20, 2020年2月.
11.	青田桂子, 山ノ井朋子, 可児耕一, 東雅之 : 唾液腺導管細胞の IFN-γ 誘導性CXCL10 過剰発現における MMP-9 の関与, 第56回日本口腔組織培養学会学術集会, 2019年11月.
12.	西窪美波, 可児耕一, 桃田幸弘, 青田桂子, 松本文博, 山ノ井朋子, 中原崇道, 東雅之 : 上唇に生じた疣贅性黄色腫の1例, 第67回NPO法人日本口腔科学会中国・四国地方部会, 2019年10月.
13.	中原崇道, 青田桂子, 西窪美波, 山ノ井朋子, 可児耕一, 桃田幸弘, 松本文博, 東雅之 : 舌下神経麻痺とNumb Chin症候群を初発症状としたBurkittリンパ腫の1例, 第67回NPO法人日本口腔科学会中国・四国地方部会, 2019年10月.
14.	桃田幸弘, 高野栄之, 可児耕一, 小野信二, 松本文博, 青田桂子, 益田奈緒, 山ノ井朋子, 金川裕子, 東雅之 : 薬物療法が奏効した口腔顔面痛の11例, 第24回日本口腔顔面痛学会, 2019年9月.
15.	桃田幸弘, 高野栄之, 可児耕一, 小野信二, 東雅之 : 漢方薬が奏効した口腔扁平苔癬の2例, 第29回日本口腔内科学会・第12回日本口腔検査学会・第30回日本臨床口腔病理学会・第32回日本口腔診断学会合同学術大会, 2019年9月.
16.	青田桂子, 山ノ井朋子, 可児耕一, 石丸直澄, 東雅之 : シェーグレン症候群の病態形成におけるCXCL10-CXCR3の役割, 第28回日本シェーグレン症候群学会, 2019年9月.
17.	西窪美波, 可児耕一, 桃田幸弘, 青田桂子, 松本文博, 山ノ井朋子, 中原崇道, 東雅之 : Addison病による急性副腎不全を伴った歯性感染症の1例, 第48回日本口腔外科学会中国四国支部学術集会, 2019年5月.
18.	山ノ井朋子, 青田桂子, 高野栄之, 可児耕一, 桃田幸弘, 松本文博, 石丸直澄, 東雅之 : 舌下-オトガイ下型類皮嚢胞の一例, 第48回日本口腔外科学会中四国支部学術集会, 2019年5月.
19.	高野栄之, 桃田幸弘, 可児耕一, 宮本悦子, 東山祐陽, 飛梅悟, 郡由紀子, 河野美枝子, 東雅之 : バリフリBOX 2018における口腔ケア等に関するアンケート調査, 第16回日本口腔ケア学会総会・学術大会, 2019年4月.
20.	青田桂子, 山ノ井朋子, 可児耕一, 石丸直澄, 東雅之 : シェーグレン症候群の病態形成におけるCXCL10-CXCR3の役割, 第73回日本口腔科学会学術集会, 2019年4月.
21.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 高瀬奈緒, 山ノ井朋子, 小野信二, 金川裕子, 東雅之 : 当科における直接経口抗凝固薬投与下の観血的処置の現状, 第73回日本口腔科学会学術集会, 2019年4月.
22.	青田桂子, 山ノ井朋子, 可児耕一, 益田奈緒, 高野栄之, 桃田幸弘, 松本文博, 東雅之 : 若年周期性好中球減少症患者の抜歯経験, 第63回日本口腔外科学会総会・学術集会, 2018年11月.
23.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 高瀬奈緒, 金川裕子, 山ノ井朋子, 宮本由貴, 東雅之 : 漢方薬が奏効した難治性口内炎の6例, 第63回日本口腔外科学会学術大会, 2018年11月.
24.	桃田幸弘, 高野栄之, 可児耕一, 高瀬奈緒, 宮本由貴, 富岡重正, 東雅之 : 茵蔯蒿湯と五苓散の併用が奏効した難治性口内炎の2例, 第28回日本口腔内科学会・第31回日本口腔診断学会合同学術大会, 2018年9月.
25.	高野栄之, 桃田幸弘, 寺田賢治, 東雅之 : 画像解析による口腔内写真からのデンタルチャート作成, 第17回警察歯科医会全国大会, 2018年8月.
26.	桃田幸弘, 高野栄之, 可児耕一, 東雅之 : アミトリプチリン塩酸塩と加工附子末製剤の併用が奏効した特発性歯痛の1例, 第23回日本口腔顔面痛学会, 2018年7月.
27.	高野栄之, 宮本由貴, 福井誠, 玉木直文, 伊藤博夫, 東雅之 : 当院栄養サポートチームにおける歯科医師連携の現況, 四国歯学会第53回例会, 2018年7月.
28.	青田桂子, 山ノ井朋子, 可児耕一, 桃田幸弘, 東雅之 : 唾液腺細胞における CXCL10 発現機構の解析, 第72回日本口腔科学会学術集会, 2018年5月.
29.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二, 東雅之 : 一次性舌痛症における唾液アミラーゼ活性測定の有用性, 第72回日本口腔科学会学術集会, 2018年5月.
30.	高野栄之, 小野信二, 福井誠, 玉木直文, 吉岡昌美, 桃田幸弘, 伊藤博夫, 東雅之 : 徳島大学病院NSTにおける歯科医師連携の現況と課題, 第15回日本口腔ケア学会総会・学術大会, 2018年4月.
31.	高野栄之, 岡本拓也, 桃田幸弘, 寺田賢治, 東雅之 : 画像解析を用いたデンタルチャート作成の試み, 第11回日本法歯科医学会学術大会, 2017年11月.
32.	青田桂子, 山ノ井朋子, 可児耕一, 東雅之 : セファランチンはヒト唾液腺導管細胞由来IFNγ誘導性CXCL10を抑制する, 第54回日本口腔組織培養学会学術大会, 2017年11月.
33.	青田桂子, 宮本由貴, 高瀬奈緒, 山ノ井朋子, 高野栄之, 可児耕一, 桃田幸弘, 松本文博, 東雅之 : 当科における顎骨骨髄炎の臨床統計的検討, 第62回日本口腔外科学会総会・学術総会, 2017年10月.
34.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二, 東雅之 : 三剤併用が奏効した一次性舌痛症の3例-口腔領域の難治性疼痛への対応-, 第62回日本口腔外科学会学術大会, 2017年10月.
35.	高瀬奈緒, 青田桂子, 桃田幸弘, 松本文博, 可児耕一, 高野栄之, 山ノ井朋子, 宮本由貴, 小野信二, 東雅之 : 左側下顎骨筋突起基部から埋伏歯の突出を認めた角化嚢胞性歯原性腫瘍の1例, 第46回日本口腔外科学会中国四国支部学術集会, 2017年5月.
36.	宮本由貴, 桃田幸弘, 可児耕一, 松本文博, 青田桂子, 高野栄之, 高瀬奈緒, 山ノ井朋子, 小野信二, 牛尾綾, 石丸直澄, 東雅之 : 上顎に発生した石灰化を伴わない石灰化上皮性歯原性腫瘍の1例, 第46回日本口腔外科学会中国四国支部学術集会, 2017年5月.
37.	桃田幸弘, 高野栄之, 可児耕一, 東雅之 : 五苓散と加工附子末製剤の併用が奏効した三叉神経痛の1例, 第71回日本口腔科学会学術集会, 2017年4月.
38.	高野栄之, 桃田幸弘, 小野信二, 金川裕子, 吉岡昌美, 松本文博, 青田桂子, 可児耕一, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 東雅之 : 徳島大学病院緩和ケアセンターにおける口腔機能管理の現況と課題, 第71回日本口腔科学会学術集会, 2017年4月.
39.	青田桂子, 山ノ井朋子, 可児耕一, 石丸直澄, 東雅之 : シェーグレン症候群におけるCXCR3+マクロファージの動態, 第71回日本口腔科学会学術集会, 2017年4月.
40.	高野栄之, 桃田幸弘, 小野信二, 可児耕一, 松本文博, 青田桂子, 金川裕子, 東雅之 : 口腔機能管理を行った重症多形滲出性紅斑の2例, 第14回日本口腔ケア学会総会・学術大会, 2017年4月.
41.	高野栄之, 桃田幸弘, 可児耕一, 中津忠則, 東雅之 : 徳島赤十字ひのみね総合療育センター歯科における受診患者の動向, 第61回日本口腔外科学会学術大会, 2016年11月.
42.	可児耕一, 桃田幸弘, 高野栄之, 松本文博, 青田桂子, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二, 東雅之 : ピロカルピン塩酸塩顆粒による有害事象の発現についての検討, 第61回日本口腔外科学会学術大会, 2016年11月.
43.	桃田幸弘, 宮本由貴, 高野栄之, 可児耕一, 東雅之 : 経上顎洞的対孔形成術と化学療法を施行した上顎洞アスペルギルス症の1例, 第61回日本口腔外科学会学術大会, 2016年11月.
44.	青田桂子, 山ノ井朋子, 可児耕一, 石丸直澄, 東雅之 : ヒト唾液腺細胞株における CXCL10 の発現機能解析, 第53回日本口腔組織培養学会学術大会, 2016年11月.
45.	大塚邦紘, 牛尾綾, 宮本由貴, 鯨岡聡子, 山田安希子, 青田桂子, 工藤保誠, 東雅之, 石丸直澄 : 1, 第64回日本口腔科学会中国四国地方部会, Vol.64, 2016年10月.
46.	宮本由貴, 桃田幸弘, 可児耕一, 松本文博, 青田桂子, 高野栄之, 高瀬奈緒, 山ノ井朋子, 小野信二, 東雅之 : 上顎歯肉に発症した骨髄肉腫の1例, 第64回日本口腔科学会中四国地方部会, 2016年10月.
47.	高瀬奈緒, 桃田幸弘, 可児耕一, 宮本由貴, 山ノ井朋子, 小野信二, 高野栄之, 青田桂子, 松本文博, 牛尾綾, 石丸直澄, 東雅之 : 上唇粘膜下に生じた血管筋腫の1例, 第64回日本口腔科学会中四国地方部会, 2016年10月.
48.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二, 東雅之 : プレガバリン，トラマドール塩酸塩/アセトアミノフェン配合錠および加工附子末製剤の三剤併用が奏効した口腔顔面痛の3例, 第21回日本口腔顔面痛学会, 2016年9月.
49.	高瀬奈緒, 青田桂子, 宮本由貴, 山ノ井朋子, 小野信二, 高野栄之, 可児耕一, 桃田幸弘, 石丸直澄, 東雅之 : 口蓋に生じた筋上皮腫の1例, 第45回日本口腔外科学会中四国支部学術集会, 2016年5月.
50.	青田桂子, 山ノ井朋子, 可児耕一, 桃田幸弘, 東雅之 : 唾液腺細胞における CXCL10 発現機構の解析, 第72回日本口腔科学会学術集会, 2016年5月.
51.	可児耕一, 桃田幸弘, 青田桂子, 高野栄之, 東雅之 : 抜歯後出血に対して動脈塞栓術が奏効した1例, 第45回日本口腔外科学会中国四国支部学術集会, 2016年5月.
52.	桃田幸弘, 宮本由貴, 高野栄之, 可児耕一, 東雅之 : 特発性自律神経ニューロパチーの抜歯術の1例-心拍間変異分析による術中管理について-, 第70回日本口腔科学会学術集会, 2016年4月.
53.	山ノ井朋子, 青田桂子, 高野栄之, 可児耕一, 松本文博, 桃田幸弘, 高瀬奈緒, 宮本由貴, 石丸直澄, 東雅之 : シェーグレン症候群患者におけるセファランチンの作用機序の解明, 第70回日本口腔科学会学術集会, 2016年4月.
54.	青田桂子, 山ノ井朋子, 可児耕一, 高野栄之, 桃田幸弘, 松本文博, 石丸直澄, 東雅之 : Sjögren 症候群唾液腺における IP-10 の発現制御機構, 第70回日本口腔科学会学術集会, 2016年4月.
55.	高野栄之, 小野信二, 桃田幸弘, 後藤崇晴, 水頭英樹, 金川裕子, 松本文博, 青田桂子, 可児耕一, 東雅之 : 徳島大学病院における癌化学療法に対する周術期口腔機能管理の現状と課題, 第13回日本口腔ケア学会総会・学術大会, 2016年4月.
56.	可児耕一, 桃田幸弘, 高野栄之, 青田桂子, 山ノ井朋子, 東雅之 : 口腔癌移植ヌードマウスに対するdocrtaxel・γ-tocotrienol併用療法による抗腫瘍効果の検討, 第52回日本口腔組織培養学会学術大会, 2015年11月.
57.	佐藤南, 永田久美子, 堀内信也, 黒田晋吾, 山村佳子, 東雅之, 田中栄二 : 低出力パルス超音波は唾液腺炎に対して抗炎症作用を有し唾液分泌を促進させる, 第74回日本矯正歯科学会大会プログラム・抄録集, 164, 2015年11月.
58.	宮本由貴, 松本文博, 桃田幸弘, 高野栄之, 可児耕一, 青田桂子, 高瀬奈緒, 近藤智香, 山ノ井朋子, 小野信二, 東雅之 : 糖尿病による顎口腔領域の神経障害性疼痛が疑われた1例, 第63回日本口腔科学会中国・四国地方部会, Vol.0, No.0, 0, 2015年11月.
59.	高野栄之, 桃田幸弘, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 近藤智香, 小野信二, 高瀬奈緒, 宮本由貴, 金川裕子, 東雅之 : 小児の舌根部に生じた骨性分離腫の1例, 第63回日本口腔科学会中国・四国地方部会, Vol.0, No.0, 0, 2015年11月.
60.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 東雅之 : 一次性舌痛症に関する健康関連QOLの調査-SF-36v2日本語版を用いて-, 第60回日本口腔外科学会学術大会, 2015年10月.
61.	桃田幸弘, 東雅之 : 舌痛をどう捉え，どう対応するか, 第60回日本口腔外科学会学術大会, 2015年10月.
62.	青田桂子, 山ノ井朋子, 近藤智香, 高野栄之, 武川大輔, 山村佳子, 可児耕一, 桃田幸弘, 松本文博, 東雅之 : 進行期肺がん患者の口腔管理∼ゾレドロン酸，デノスマブ投与前の歯科治療を考える∼, 第12回口腔ケア学会総会, 2015年6月.
63.	高野栄之, 桃田幸弘, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 金川裕子, 小野信二, 東雅之 : 徳島大学病院口腔内科発足前後5年間における外来ならびに入院患者動向について, 第47回四国歯学会例会・第34回四国歯学会総会, 2015年6月.
64.	桃田幸弘, 可児耕一, 高野栄之, 松本文博, 青田桂子, 武川大輔, 山ノ井朋子, 近藤智香, 東雅之 : 新規口腔ケア製品「ペプチサルシリーズ」の使用感に関する調査, 第12回日本口腔ケア学会, 2015年6月.
65.	青田桂子, 山ノ井朋子, 近藤智香, 可児耕一, 高野栄之, 桃田幸弘, 松本文博, 東雅之 : Sjögren 症候群唾液腺における IP-10 の発現機能解析, 第69回日本口腔科学会学術集会, 2015年5月.
66.	桃田幸弘, 細木眞紀, 二宮雅美, 高野栄之, 松香芳三, 東雅之 : 口腔ならびに呼吸器症状を伴った歯科用金属によるアレルギーの1例, 第69回日本口腔科学会学術集会, 2015年5月.
67.	近藤智香, 松本文博, 桃田幸弘, 可児耕一, 高野栄之, 青田桂子, 山ノ井朋子, 東雅之 : 当科における顎関節脱臼症例の臨床的検討, 第44回日本口腔外科学会中国四国支部学術集会, 2015年4月.
68.	濱本恵, 篠永晴美, 佐藤紀, 兼本ひろみ, 東雅之, 松山美和, 江西哲也, 加藤真介 : 多発性筋炎により嚥下障害を呈した一症例, 日本摂食·嚥下リハビリテーション学会雑誌, Vol.18, No.3, S99, 2014年12月. (キーワード) 嚥下障害(リハビリテーション,病因) 筋炎-多発性(合併症) リハビリテーション嚥下訓練ヒト中年(45∼64) 女
69.	青田桂子, 山村佳子, 山ノ井朋子, 近藤智香, 武川大輔, 可児耕一, 高野栄之, 桃田幸弘, 松本文博, 東雅之 : Sjögren 症候群唾液腺における IP-10 の役割, 第51回日本口腔組織培養学会学術大会, 2014年11月.
70.	山村佳子, 滝沢宏光, 松本文博, 桃田幸弘, 青田桂子, 武川大輔, 可児耕一, 高野栄之, 山ノ井朋子, 近藤智香, 金川裕子, 高瀬奈緒, 十川悠香, 東雅之 : 肺癌患者における周術期口腔機能管理の有用性について-術後合併症の観点より-, 第62回NPO法人日本口腔科学会中国・四国地方部会, 2014年10月.
71.	高野栄之, 桃田幸弘, 可児耕一, 橋本俊顕, 久保宜明, 東雅之 : 頬部脂肪萎縮性脂肪織炎の1例, 第62回NPO法人日本口腔科学会中国・四国地方部会, 2014年10月.
72.	佐藤南, 永田久美子, 堀内信也, 黒田晋吾, 山村佳子, 東雅之, 田中栄二 : 唾液腺に対する低出力パルス超音波照射の影響の検討, 第73回日本矯正歯科学会大会プログラム・抄録集, 176, 2014年10月.
73.	桃田幸弘, 可児耕一, 高野栄之, 松本文博, 青田桂子, 山ノ井朋子, 近藤智香, 東雅之 : 一次性舌痛症に対する心拍間変異分析-Time-Domain測定の意義-, 第59回日本口腔外科学会学術大会, 2014年10月.
74.	高野栄之, 桃田幸弘, 可児耕一, 松本文博, 青田桂子, 山ノ井朋子, 近藤智香, 東雅之 : 5-FUによるヒト口腔粘膜上皮細胞の増殖抑制とγ-T3によるその解除機構の検討, 第59回日本口腔外科学会学術大会, 2014年10月.
75.	青田桂子, 山ノ井朋子, 近藤智香, 高野栄之, 桃田幸弘, 可児耕一, 松本文博, 東雅之 : Sjögren症候群におけるサイトカイン/ケモカイン発現の解析, 第59回日本口腔外科学会学術大会, 2014年10月.
76.	可児耕一, 桃田幸弘, 高野栄之, 松本文博, 青田桂子, 山村佳子, 武川大輔, 山ノ井朋子, 近藤智香, 金川裕子, 東雅之 : 徳島大学病院口腔内科組織改編前後の患者動向について, 第24回日本口腔内科学会, 2014年9月.
77.	石川久子, 永井浩美, 吉岡昌美, 伊賀弘起, 東雅之, 松尾敬志, 丹黒章 : 外来化学療法患者の口腔健康管理に対する意識調査, 第11回日本口腔ケア学会・旭川, 2014年6月.
78.	永井浩美, 吉岡昌美, 石川久子, 東雅之, 河野文昭, 松尾敬志 : 地域歯科診療所における医科歯科連携の実態調査ー病院・施設への訪問診療の現状分析ー, 第11回日本口腔ケア学会, 2014年6月.
79.	青田桂子, 山村佳子, 可児耕一, 高野栄之, 桃田幸弘, 松本文博, 河野文昭, 松尾敬志, 東雅之 : 徳島大学病院における周術期口腔機能管理の現状と課題, 第11回日本口腔ケア学会総会・学術大会, 2014年6月.
80.	山村佳子, 青田桂子, 桃田幸弘, 松本文博, 可児耕一, 高野栄之, 東雅之 : 頭頸部領域に対する癌化学放射線療法による口腔粘膜炎の実態調査, 第11回日本口腔ケア学会総会, 2014年6月.
81.	可児耕一, 桃田幸弘, 高野栄之, 松本文博, 青田桂子, 山村佳子, 武川大輔, 山ノ井朋子, 近藤智香, 金川裕子, 東雅之 : 徳島大学病院口腔内科発足前後の患者動向について, 第45回四国歯学会例会・第33回四国歯学会総会, 2014年6月.
82.	青田桂子, 山村佳子, 可児耕一, 高野栄之, 茂木勝美, 松本文博, 石丸直澄, 東雅之 : ドライマウス患者における唾液中のTNF-αとMMP-9発現に関する研究, 第68回日本口腔科学会学術集会, 2014年5月.
83.	山村佳子, 茂木勝美, 青田桂子, 桃田幸弘, 東雅之 : 唾液腺腺房細胞におけるMAPK経路を介したAQP5発現機構-SMRTとHDAC3発現からの解析-, 第68回日本口腔科学会学術集会, 2014年5月.
84.	桃田幸弘, 可児耕一, 高野栄之, 松本文博, 茂木勝美, 青田桂子, 山村佳子, 東雅之 : 一次性舌痛症における手掌部発汗の発現-皮膚水分量測定の有用性について-, 第68回日本口腔科学会学術集会, 2014年5月.
85.	松本文博, 桃田幸弘, 高野栄之, 山村佳子, 可児耕一, 青田桂子, 茂木勝美, 東雅之 : 顎関節脱臼患者における臨床的検討, 第43回日本口腔外科学会中・四国地方会, 2014年4月.
86.	高野栄之, 桃田幸弘, 湯淺哲也, 東雅之 : イムノクロマト法を用いた口腔カンジダ症迅速診断-往診診療における臨床的有用性-, 第3回健康科学創成・栄養連携部門ミニフォーラム, 2014年4月.
87.	山ノ井朋子, 青田桂子, 近藤智香, 山村佳子, 高野栄之, 可児耕一, 桃田幸弘, 松本文博, 東雅之 : 抜歯後出血を契機に診断された後天性von Willebrand症候群の1例, 第43回日本口腔外科学会中四国支部学術集会, 2014年4月.
88.	山村佳子, 茂木勝美, 青田桂子, 東雅之 : ヒト唾液腺腺房細胞におけるAQP5発現機構 -MAPK経路の関与-, 日本口腔組織培養学会設立50周年記念学術大会, 2013年11月.
89.	可児耕一, 桃田幸弘, 高野栄之, 青田桂子, 東雅之 : 下顎歯肉に生じた周辺性エナメル上皮腫の1例, 第61回日本口腔科学会中国・四国地方部会, 2013年11月.
90.	可児耕一, 桃田幸弘, 高野栄之, 青田桂子, 山村佳子, 東雅之 : ヒト口腔癌移植ヌードマウスに対するdocetaxel・γ-tocotrienol併用による抗腫瘍効果の検討, 第12回中四国口腔癌研究会, 2013年11月.
91.	山村佳子, 青田桂子, 松本文博, 桃田幸弘, 茂木勝美, 可児耕一, 高野栄之, 東雅之 : 入院精神疾患患者に対する歯科介入について, 第30回日本障碍者歯科学会学術大会, 2013年10月.
92.	石川久子, 永井浩美, 十川悠香, 吉岡昌美, 日野出大輔, 東雅之, 河野文昭 : 大学病院を拠点とした医科歯科地域連携の取り組みと活動状況, 日本歯科衛生学会第8回学術大会, 2013年9月.
93.	十川悠香, 石川久子, 田口侑子, 武川香織, 高橋侑子, 廣瀬薫, 永井浩美, 吉岡昌美, 東雅之, 河野文昭 : 周術期口腔機能管理の現状分析から見えてきた課題, 日本歯科衛生学会第8回学術大会, 2013年9月.
94.	青田桂子, 可児耕一, 山村佳子, 高野栄之, 桃田幸弘, 松本文博, 東雅之 : 口腔粘膜に初発した自己免疫性水疱症5例の臨床的検討, 第23回日本口腔内科学会, 2013年9月.
95.	十川悠香, 青田桂子, 石川久子, 田口侑子, 武川香織, 高橋侑子, 廣瀬薫, 永井浩美, 吉岡昌美, 菅原千恵子, 山村佳子, 高野栄之, 可児耕一, 茂木勝美, 桃田幸弘, 松本文博, 東雅之, 河野文昭 : 徳島大学病院における周術期口腔機能管理の現状, 第10回日本口腔ケア学会・総会, 2013年6月.
96.	山村佳子, 桃田幸弘, 青田桂子, 高野栄之, 東雅之 : 徳島大学病院腎臓内科との医・歯連携 - 腎疾患治療前からの積極的介入 -, 第10回日本口腔ケア学会学術大会, 2013年6月.
97.	桃田幸弘, 茂木勝美, 青田桂子, 高野栄之, 可児耕一, 東雅之 : ワルファリン療法中に急速に増大・破裂した軟硬口蓋粘膜下血腫の1例, 第67回日本口腔科学会学術集会, 2013年5月.
98.	山村佳子, 青田桂子, 高野栄之, 可児耕一, 桃田幸弘, 東雅之 : ヒト唾液腺腺房細胞における恒常的AQP5発現制御機構, 第67回日本口腔科学会学術集会, 2013年5月.
99.	青田桂子, 山村佳子, 可児耕一, 高野栄之, 桃田幸弘, 松本文博, 石丸直澄, 東雅之 : シェーグレン症候群に対する新規治療戦略―唾液腺腺房構造の破壊を阻止する-, 第67回日本口腔科学会学術集会, 2013年5月.
100.	山村佳子, 桃田幸弘, 青田桂子, 高野栄之, 可児耕一, 東雅之 : 徳島大学病院腎臓内科との医・歯連携―腎疾患患者の口腔管理について-, 第42回日本口腔外科学会中国四国支部学術集会, 2013年4月.
101.	青田桂子, 高野栄之, 可児耕一, 山村佳子, 東雅之 : リツキシマブの投与によって生じた口腔・上部消化管潰瘍の1例, 第57回日本口腔外科学会総会, 2013年.
102.	青田桂子, 山村佳子, 可児耕一, 茂木勝美, 桃田幸弘, 東雅之 : 抗TNF製剤のヒト唾液腺腺房細胞に及ぼす影響―抗TNF製剤はシェーグレン症候群の治療薬と成り得るか―, 第49回日本口腔組織培養学会, 2012年11月.
103.	青田桂子, 高野栄之, 可児耕一, 山村佳子, 東雅之 : リツキシマブ投与半年後に難治性口底潰瘍を生じた原発性マクログロブリン血症の1例, 第57回日本口腔外科学会総会学術大会, 2012年10月.
104.	東雅之 : 臨床における唾液腺機能再生医療, 第57回日本口腔外科学会総会学術大会, 2012年10月.
105.	茂木勝美, 桃田幸弘, 高野栄之, 可児耕一, 青田桂子, 山村佳子, 東雅之 : 抜歯後の止血困難をきっかけに発見された後天性血友病の1例, 第57回日本口腔外科学会総会学術大会, 2012年10月.
106.	山村佳子, 青田桂子, 茂木勝美, 桃田幸弘, 東雅之 : 加齢に伴う唾液腺機能低下に対するDNA脱メチル化剤の有効性, 第57回日本口腔外科学会総会学術大会, 2012年10月.
107.	可児耕一, 桃田幸弘, 高野栄之, 松本文博, 茂木勝美, 青田桂子, 山村佳子, 山田佑子, 山ノ井朋子, 原田道人, 東雅之 : ドセタキセルとg-トコトリエノールの併用による舌癌細胞株に対する抗腫瘍効果の検討, 第57回日本口腔外科学会総会学術大会, 2012年10月.
108.	山田佑子, 青田桂子, 桃田幸弘, 松本文博, 可児耕一, 大守真由子, 山村佳子, 高野栄之, 茂木勝美, 東雅之 : 頬粘膜下に生じた炎症性偽嚢胞の1例, 第60回日本口腔科学会中国四国地方部会, 2012年10月.
109.	山村佳子, 青田桂子, 茂木勝美, 山ノ井朋子, 可児耕一, 東雅之 : 加齢関連メチル化遺伝子AQP5の機能回復と唾液分泌促進作用, 第60回日本口腔科学会中国四国地方部会, 2012年10月.
110.	山村佳子, 青田桂子, 大守真由子, 松本文博, 東雅之 : 精神疾患患者の歯科介入の重要性についての検討, 第29回日本障害者歯科学会学術大会, 2012年9月.
111.	高野栄之, 桃田幸弘, 可児耕一, 原田道人, 松本文博, 茂木勝美, 青田桂子, 山村佳子, 花木秀明, 東雅之 : カンジダ検出イムノクロマトを用いた口腔カンジダ迅速検査法の有用性, 第25回日本口腔診断学会, 2012年9月.
112.	青田桂子, 茂木勝美, 山村佳子, 高野栄之, 東雅之 : シェーグレン症候群患者におけるセファランチンの唾液分泌促進効果, 第21回シェーグレン症候群学会学術集会, 2012年9月.
113.	青田桂子, 山村佳子, 大守真由子, 桃田幸弘, 東雅之 : 徳島大学病院精神科神経科入院患者における口腔ケアの有用性について, 第9回日本口腔ケア学会学術総会, 2012年6月.
114.	青田桂子, 山村佳子, 大守真由子, 東雅之 : シェーグレン症候群患者の唾液腺腺房構造破壊阻止ーセファランチンの有効性に関する臨床病理学的研究ー, 第66回日本口腔科学会学術集会, 2012年5月.
115.	可児耕一, 桃田幸弘, 高野栄之, 松本文博, 茂木勝美, 青田桂子, 山村佳子, 大守真由子, 東雅之 : 舌癌細胞株に対するドセタキセルの抗腫瘍効果に及ぼすg-tocotrienolの影響, 第66回日本口腔科学会学術集会, 2012年5月.
116.	青田桂子, 茂木勝美, 桃田幸弘, 石丸直澄, 東雅之 : シェーグレン症候群患者の唾液腺腺房構造破壊阻止―セファランチンの有効性に関する臨床病理学的研究―, 第66回日本口腔科学会学術総会, 2012年5月.
117.	高野栄之, 桃田幸弘, 可児耕一, 青田桂子, 大守真由子, 松本文博, 茂木勝美, 山村佳子, 河野文昭, 東雅之 : 徳島大学病院ICUにおける口腔ケアで遭遇する舌褥瘡性潰瘍に対する試み, 第41回(社)日本口腔外科学会中・四国地方会, 2012年4月.
118.	山村佳子, 桃田幸弘, 高野栄之, 青田桂子, 大守真由子, 東雅之 : 医科疾患を有する患者の治療前歯科口腔ケア介入について, 第41回日本口腔外科学会中四国地方会, 2012年4月.
119.	高野栄之, 桃田幸弘, 可児耕一, 青田桂子, 東雅之 : 徳島大学病院における口腔ケアで遭遇する舌褥瘡性潰瘍に対する試み, 第41回日本口腔外科学会中四国地方会, 2012年4月.
120.	青田桂子, 山村佳子, 大守真由子, 東雅之 : 徳島大学病院精神科神経科患者に対する歯科治療に関する検討, 第21回(社)日本有病者歯科医療学会学術総会, 2012年3月.
121.	山村佳子, 茂木勝美, 山ノ井朋子, 桃田幸弘, 高野栄之, 可児耕一, 青田桂子, 東雅之 : 加齢マウスにおける唾液分泌/AQP5発現低下に対するDNA脱メチル化剤の有効性の検討, 第59回日本口腔科学会中国四国地方部会, 2011年11月.
122.	山村佳子, 茂木勝美, 青田桂子, 桃田幸弘, 東雅之 : TNF-αによる唾液腺腺房細胞でのヒストンH4アセチル化を介したAQP5発現抑制, 第48回日本口腔組織培養学会学術大会, 2011年11月.
123.	高野栄之, 桃田幸弘, 可児耕一, 山村佳子, 松本文博, 細川浩良, 東雅之 : 舌痛症患者に対する知覚・痛覚定量分析装置による痛みの客観的評価, 日本口腔科学会雑誌, Vol.60, No.1, 121, 2011年11月.
124.	山村佳子, 茂木勝美, 桃田幸弘, 青田桂子, 可児耕一, 高野栄之, 東雅之 : 唾液腺線房細胞におけるTNF-αによるAQP5発現抑制機構, 第56回日本口腔外科学会総会, 2011年10月.
125.	山村佳子, 茂木勝美, 桃田幸弘, 青田桂子, 可児耕一, 高野栄之, 東雅之 : 唾液腺腺房細胞におけるTNF-aによるAQP5発現抑制機構, 第56回日本口腔外科学会総会学術大会, 2011年10月.
126.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 茂木勝美, 青田桂子, 山村佳子, 東雅之 : 当科を受診した舌痛症患者の臨床統計学的検討 ―自律神経系の関与について―, 第56回日本口腔外科学会総会学術大会, 2011年10月.
127.	高野栄之, 桃田幸弘, 東雅之 : 舌痛症患者に対する知覚，痛覚定量分析装置による痛みの客観的評価, 2011年6月.
128.	青田桂子, 松本憲, 由良義明, 東雅之 : 10歳女児に発症した開花性骨異型性の長期治療経過, 第40回(社)日本口腔外科学会中・四国地方会, 2011年5月.
129.	高野栄之, 桃田幸弘, 可児耕一, 山村佳子, 茂木勝美, 松本文博, 東雅之 : 抗癌剤誘発口腔粘膜炎発症モデルハムスターにおける致死因子としての口腔粘膜炎の役割, 第40回日本口腔外科学会中国四国地方会, 2011年5月.
130.	青田桂子, 松本憲, 金崎朋彦, 由良義明, 東雅之 : 10歳女児に発症した開花性骨異形成症の長期治療経過, 第40回日本口腔外科学会中国四国地方会, 2011年5月.
131.	高野栄之, 桃田幸弘, 可児耕一, 松本文博, 茂木勝美, 細川浩良, 山村佳子, 東雅之 : 副オトガイ孔から走行する神経様組織の切断により口腔異常感覚が改善した症候性三叉神経痛の1例, 第65回日本口腔科学会学術集会, 2011年4月.
132.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 茂木勝美, 細川浩良, 山村佳子, 東雅之 : 舌痛を主訴に当科を受診した患者の臨床統計学的検討, 第65回日本口腔科学会学術集会, 2011年4月.
133.	茂木勝美, 東雅之 : シェーグレン症候群唾液腺へのリンパ球浸潤における性ホルモン修飾酵素の役割, 2010年11月.
134.	可児耕一, 松本文博, 山村佳子, 細川浩良, 高野栄之, 桃田幸弘, 茂木勝美, 東雅之 : 口腔白板症の臨床病理学的検討―悪性化の指標を探る―, 第58回日本口腔科学会中・四国地方会, 2010年11月.
135.	山村佳子, 桃田幸弘, 高野栄之, 細川浩良, 東雅之 : カンジダ菌の検出と口腔乾燥の関連性, 第19回日本口腔感染症学会総会, 2010年11月.
136.	桃田幸弘, 茂木勝美, 東雅之 : 単純性骨嚢胞を疑う骨性異形成症と考えられた1例, 2010年11月.
137.	桃田幸弘, 茂木勝美, 東雅之 : 臼歯部離開を呈した閉口末期の閉口障害の1例, 2010年11月.
138.	茂木勝美, 東雅之 : シェーグレン症候群唾液腺へのリンパ球浸潤における性ホルモン修飾酵素の役割, 2010年10月.
139.	細川浩良, 桃田幸弘, 松本文博, 茂木勝美, 高野栄之, 山村佳子, 可児耕一, 藤澤健司, 湯淺哲也, 工藤景子, 東雅之 : 口腔白板症の臨床病理学的検討 ―悪性化の指標を探る―, 第55回日本口腔外科学会総会, 2010年10月.
140.	桃田幸弘, 東雅之 : 舌痛を訴える患者さんについて考えるー舌痛症を中心にー, 2010年7月.
141.	東雅之 : 徳島大学歯学部における口腔内科学分野の役割, 2010年7月.
142.	山村佳子, 桃田幸弘, 高野栄之, 可児耕一, 茂木勝美, 松本文博, 東雅之 : 当科における口腔カンジダ症の臨床統計学的検討, 第39回(社)日本口腔外科学会中・四国地方会, 2010年5月.
143.	佐々井明子, 大江剛, 内田大亮, 尾上富太郎, 茂木勝美, 玉谷哲也, 東雅之, 永井宏和, 宮本洋二 : 口腔癌由来液性因子がOK-432による末梢血単核球のIFN-γ産生に与える影響, 日本口腔腫瘍学会誌, Vol.21, No.4, 342-343, 2009年.

その他・研究会:

1.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 高瀬奈緒, 山ノ井朋子, 小野信二, 金川裕子, 東雅之 : 葛根湯が奏効した特発性first bite syndromeの1例-心拍間変異分析と健康関連QOLの評価について-, 徳島大学歯学部口腔内科同門会誌, Vol.35, 8-12, 2020年12月.
2.	桃田幸弘, 高野栄之, 可児耕一, 松本文博, 青田桂子, 高瀬奈緒, 山ノ井朋子, 小野信二, 金川裕子, 東雅之 : 当科における直接経口抗凝固薬投与下の観血的処置の現状, 徳島大学歯学部口腔内科同門会誌, Vol.34, 8-12, 2019年12月.
3.	可児耕一, 桃田幸弘, 高野栄之, 松本文博, 青田桂子, 青田桂子, 山ノ井朋子, 高瀬奈緒, 宮本由貴, 小野信二, 東雅之 : ピロカルピン塩酸塩顆粒による有害事象の発現についての検討, 徳島大学歯学部口腔内科同門会誌,, Vol.31, 10-11, 2016年.
4.	里見淳一郎, 山村佳子, 青田桂子, 武川大輔, 松本文博, 十川悠香, 東雅之 : 徳島大学病院脳卒中センターにおける口腔管理の意義について, 第17回徳島脳卒中研究会, 2015年2月.
5.	高野栄之, 桃田幸弘, 可児耕一, 東雅之 : γ-トコトリエノールはNrf2-Keap1経路と抗酸化タンパク質の誘導を介して5-FUによる口腔粘膜上皮細胞の増殖抑制を解除する, 第13回中四国口腔癌研究会, 2014年10月.
6.	可児耕一, 桃田幸弘, 高野栄之, 青田桂子, 松本文博, 山村佳子, 武川大輔, 山ノ井朋子, 近藤智香, 金川裕子, 東雅之 : がん治療における周術期口腔機能管理の現状と課題, 徳島大学病院Cancer Board, 2014年9月.
7.	可児耕一, 桃田幸弘, 高野栄之, 青田桂子, 東雅之 : 下顎歯肉に生じた周辺性エナメル上皮腫の1例, 徳島大学歯学部口腔内科同門会誌, Vol.28, 13-14, 2013年.
8.	青田桂子, 山村佳子, 茂木勝美, 石丸直澄, 東雅之 : シェーグレン症候群患者に対するセファランチンの有効性に関する臨床病理学的研究, 四国歯学会雑誌, 2012年3月.
9.	高野栄之, 桃田幸弘, 可児耕一, 東雅之 : 口腔カンジダ症に対する迅速免疫学的検査-イムノクロマト法の有用性について-, 徳島大学歯学部口腔内科同門会誌, Vol.27, 10-11, 2012年.
10.	高野栄之, 桃田幸弘, 可児耕一, 松本文博, 茂木勝美, 山村佳子, 東雅之 : 副オトガイ孔を走行する神経様組織の切断によって口唇感覚異常が改善した症候性三叉神経痛の1例, 徳島大学歯学部口腔内科同門会誌, Vol.26, 8-10, 2011年.
11.	高野栄之, 桃田幸弘, 可児耕一, 東雅之 : 知覚・痛覚定量分析装置による舌痛症の痛みの定量的評価, 徳島大学歯学部口腔内科同門会誌, Vol.25, 6-7, 2010年.

報告書:

1.	桃田幸弘, 高野栄之, 可児耕一, 東雅之 : ローヤルゼリーの口腔顔面痛に対する治療効果の検討-小型脳波センサーを用いて-, 第4回みつばち研究助成基金報告書, Vol.4, 23, 2012年.
2.	高野栄之, 宮本悦子, 桃田幸弘, 可児耕一, 東雅之 : 心身障害者や自閉症児に対する蜂蜜を使用した歯みがきの有効性, 第3回みつばち研究助成基金報告書, No.3, 6, 2011年.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

シェーグレン症候群に対する病期・病態対応型シームレス医療の構築 (研究課題/領域番号: 20K10119 )
疾患関連分子群の発現制御を基盤とするシェーグレン症候群治療法の開発 (研究課題/領域番号: 17K11842 )
口腔顔面痛に対する自律神経調節機能の強化－心拍変動バイオフィードバック法の試み－ (研究課題/領域番号: 16K11888 )
口腔顔面痛の診断マーカーの探索－小型脳波センサーと光トポグラフィを用いて－ (研究課題/領域番号: 25463247 )
口腔扁平苔癬に対する新規疾患病因論とそれに基づく治療戦略 (研究課題/領域番号: 24659896 )
シェーグレン症候群に対する病期対応型テーラーメード医療の構築 (研究課題/領域番号: 23390464 )
NF-κB依存型分子プロファイリングによる口腔癌特異的バイオマーカー (研究課題/領域番号: 20592362 )
腫瘍壊死因子とアクアポリン5を分子標的としたシェーグレン症候群の新規治療法の開発 (研究課題/領域番号: 20592337 )
NF-κBシグナリング制御による口腔癌に対するリンパ管新生阻止療法の開発 (研究課題/領域番号: 18592221 )
頭頚部癌に対する新規薬剤併用療法の開発-DNA脱メチル化剤と抗癌剤の併用- (研究課題/領域番号: 15390617 )
Toll様受容体-4シグナル:口腔癌における抗癌剤・放射線治療の増強効果 (研究課題/領域番号: 14207090 )
口腔癌に対する変異型IkBα遺伝子導入による抗腫瘍効果発現機構 (研究課題/領域番号: 13672102 )
口腔癌に対するiNOS遺伝子導入と放射線治療との併用療法の開発 (研究課題/領域番号: 12557176 )
口腔扁平上皮癌細胞におけるnm23遺伝子の分化誘導抑制効果とその制御 (研究課題/領域番号: 10877326 )
転写因子NF-_kBの発現抑制-唾液腺癌細胞におけるアポトーシス誘導の増強- (研究課題/領域番号: 10671884 )
唾液腺粘液嚢胞発症モデルシステムの樹立とその治療法の開発に関する研究 (研究課題/領域番号: 06557112 )
ヒト唾液腺癌細胞における新規な薬物受容体の検出と分化・アポトーシス誘導機構 (研究課題/領域番号: 06404072 )
高転移性ヒト唾液腺癌細胞株の樹立とその転移機構の解析に関する研究 (研究課題/領域番号: 05671673 )
ヒト唾液腺癌細胞を用いた細胞分化誘導剤のスクリーニングシステムの開発 (研究課題/領域番号: 05557084 )
唾液腺癌の分化誘導療法に関する研究 (研究課題/領域番号: 03454467 )
Ras癌遺伝子産物p21の発現からみた口腔粘膜癌の臨床的悪性度評価 (研究課題/領域番号: 62570901 )
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名誉教授 : 東雅之

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名誉教授 : 東 雅之

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名誉教授 : 東雅之