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Research Activity

Field of Study

Biochemistry, Molecular Biology, Genetics

Subject of Study

Molecular Mechanisms of Insulin Transduction and Diabetes mellitus (insulin, signal transduction, cell proliferation and differentiation, diabetes)

Book / Paper

Book:

1. S Yamamoto, T Yoshimoto, Y Takahashi, H Suzuki, T Arakawa, Koji Kishimoto, T Oshima, GR Reddy, N Ueda, J Murakami, Y Yamamoto, C Yokoyama, Yousuke Ebina, S Matsuda, Y Konishi, Y Mimura, S Arase and M Okuma :
Mammalian lipoxygenases with special reference to arachidonate 12-lipoxygenase.,
Excerpta Medica, Jun. 1993.

Academic Paper (Judged Full Paper):

1. Asako Umehara, Mamiko Nishioka, Toshiyuki Obata, Yousuke Ebina, Hiroshi Shiota and Seiichi Hashida :
A novel ultra-sensitive enzyme immunoassay for soluble human insulin receptor ectodomain and its measurement in urine from healthy subjects and patients with diabetes mellitus.,
Clinical Biochemistry, Vol.42, No.13-14, 1468-1475, 2009.
(DOI: 10.1016/j.clinbiochem.2009.06.014,   PubMed: 19560451)
2. Tomoyuki Yuasa, Keiji Uchiyama, OGURA Yuko, Masafumi Kimura, TESHIGAWARA Kiyoshi, Toshio Hosaka, TANAKA Yoshinori, Toshiyuki Obata, SANO Hiroyuki, Kazuhiro Kishi and Yousuke Ebina :
The Rab GTPase-Activating Protein AS160 as a Common Regulator of Insulin- and Gαq-Mediated Intracellular GLUT4 Vesicle Distribution,
Endocrine Journal, Vol.56, No.3, 345-359, 2009.
(DOI: 10.1507/endocrj.K08E-216,   PubMed: 19139597)
3. L. Kyle Hoehn, Cordula Hohnen-Behrens, Anna Cederberg, E. Lindsay Wu, Nigel Turner, Tomoyuki Yuasa, Yousuke Ebina and E. David James :
IRS1-Independent Defects Define Major Nodes of Insulin Resistance,
Cell Metabolism, Vol.7, No.5, 421-433, 2008.
(DOI: 10.1016/j.cmet.2008.04.005,   PubMed: 18460333)
4. Katsuya Hirasaka, Kohno S, Goto J, Furochi H, Kazuaki Mawatari, Nagakatsu Harada, Toshio Hosaka, Yutaka Nakaya, Ishidoh K, Toshiyuki Obata, Yousuke Ebina, Gu H, Takeda S, Kyoichi Kishi and Takeshi Nikawa :
Deficiency of Cbl-b gene enhances infiltration and activation of macrophages in adipose tissue and causes peripheral insulin resistance in mice.,
Diabetes, Vol.56, No.10, 2511-2522, 2007.
(DOI: 10.2337/db06-1768,   PubMed: 17601987)
5. Toshiyuki Obata, Ichiro Yokota, Kazuhiro Yokoyama, Eiji Okamoto, Yoshiko Kanezaki, Yoshinori Tanaka, Hiroshi Maegawa, Kiyoshi Teshigawara, Fumiko Hirota, Tomoyuki Yuasa, Kazuhiro Kishi, Atsushi Hattori, Seiichi Hashida, Kazuhiko Masuda, Mitsuru Matsumoto, Toshio Matsumoto, Atsunori Kashiwagi and Yousuke Ebina :
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes mellitus.,
Diabetes, Vol.56, No.8, 2028-2035, 2007.
(DOI: 10.2337/db07-0394,   PubMed: 17563065)
6. Hossein Nazari, Akira Takahashi, Nagakatsu Harada, Kazuaki Mawatari, Masayuki Nakano, Kazuhiro Kishi, Yousuke Ebina and Yutaka Nakaya :
Angiotensin II inhibits insulin-induced actin stress fiber formation and glucose uptake via ERK1/2.,
The Journal of Medical Investigation : JMI, Vol.54, No.1,2, 19-27, 2007.
(Tokushima University Institutional Repository: 111490,   DOI: 10.2152/jmi.54.19,   PubMed: 17380010)
7. Kazuhiro Kishi, Kazuaki Mawatari, K Sakai-Wakamatsu, Tomoyuki Yuasa, M Wang, M Ogura-Sawa, Yutaka Nakaya, S Hatakeyama and Yousuke Ebina :
APS-mediated Ubiquitination of the Insulin Receptor Enhances its Internalization but does not Induce its Degradation.,
Endocrine Journal, Vol.54, No.1, 77-88, 2007.
(DOI: 10.1507/endocrj.K06-056,   PubMed: 17102568)
8. Elaine Xu, Mohan Kumar, Yi Zhang, William Ju, Toshiyuki Obata, Nina Zhang, Shiying Liu, Anna Wendt, Shaoping Deng, Yousuke Ebina, Michael B. Wheeler, Matthias Braun and Qinghua Wang :
Intra-islet insulin suppresses glucagon release via GABA-GABA(A) receptor system,
Cell Metabolism, Vol.3, No.1, 47-58, 2006.
(DOI: 10.1016/j.cmet.2005.11.015,   PubMed: 16399504,   Elsevier: Scopus)
9. Tomoyuki Yuasa, Rei Kakuhata, Kazuhiro Kishi, Toshiyuki Obata, Yasuo Shinohara, Yoshimi Bando, Keisuke Izumi, Fumiko Kajiura, Mitsuru Matsumoto and Yousuke Ebina :
Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect blood glucose levels,
Diabetes, Vol.53, No.11, 2776-2786, 2004.
(DOI: 10.2337/diabetes.53.11.2776,   PubMed: 15504957)
10. Satoshi Ugi, Takeshi Imamura, Hiroshi Maegawa, Katsuya Egawa, Ken Yoshizaki, Kun Shi, Toshiyuki Obata, Yousuke Ebina, Atsunori Kashiwagi and J. M. Olefsky :
Protein Phosphatase 2A Negatively Regulates insulin's Metabolic Signaling Pathway by Inhibiting AKT (Protein Kinase B) Activity in 3T3-L1 Adipocytes.,
Molecular and Cellular Biology, Vol.24, No.19, 8778-8789, 2004.
(DOI: 10.1128/MCB.24.19.8778-8789.2004,   PubMed: 15367694)
11. Yoshiko Kanezaki, Toshiyuki Obata, Rie Matsushima, Asako Minami, Tomoyuki Yuasa, Kazuhiro Kishi, Yoshimi Bando, Hisanori Uehara, Keisuke Izumi, Tasuku Mitani, Mitsuru Matsumoto, Yukari Takeshita, Yutaka Nakaya, Toshio Matsumoto and Yousuke Ebina :
KATP Channel Knockout Mice Crossbred with Transgenic Mice Expressing a Dominant-Negative Form of Human Insulin Receptor have Glucose Intolerance but not Diabetes,
Endocrine Journal, Vol.51, No.2, 133-144, 2004.
(DOI: 10.1507/endocrj.51.133,   PubMed: 15118262)
12. Asako Minami, Masanori Iseki, Kazuhiro Kishi, Miao Wang, Makoto Ogura, Noboru Furukawa, Sanae Hayashi, Mizuki Yamada, Toshiyuki Obata, Yukari Takeshita, Yutaka Nakaya, Yoshimi Bando, Keisuke Izumi, Shonna A Moodie, Fumiko Kajiura, Mitsuru Matsumoto, Kiyoshi Takatsu, Satoshi Takaki and Yousuke Ebina :
Increased Insulin Sensitivity and Hypoinsulinemia in APS Knockout Mice,
Diabetes, Vol.52, No.11, 2657-2665, 2003.
(DOI: 10.2337/diabetes.52.11.2657,   PubMed: 14578283)
13. Yoshiko Kanezaki, Rie Matsushima, Toshiyuki Obata, Yutaka Nakaya, Toshio Matsumoto and Yousuke Ebina :
Injection of the Insulin receptor alpha subunit increases blood glucose levels in mice,
Biochemical and Biophysical Research Communications, Vol.309, No.3, 572-577, 2003.
(DOI: 10.1016/j.bbrc.2003.08.028,   PubMed: 12963028)
14. Takashi Katome, Toshiyuki Obata, Rie Matsushima, Norihisa Masuyama, Lewis C. Cantley, Yukiko Gotoh, Kazuhiro Kishi, Hiroshi Shiota and Yousuke Ebina :
Use of RNA interference-mediated gene silencing and adenoviral overexpression to elucidate the roles of AKT/protein kinase B isoforms in insulin actions,
The Journal of Biological Chemistry, Vol.278, No.30, 28312-28323, 2003.
(DOI: 10.1074/jbc.M302094200,   PubMed: 12734182,   CiNii: 80016087388)
15. Reiko Kamei, Yoshinori Kitagawa, Michinori Kadokura, Fumiaki Hattori, Osamu Hazeki, Yousuke Ebina, Tatsuro Nishihara and Shinzo Oikawa :
Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway.,
Biochemical and Biophysical Research Communications, Vol.292, No.3, 624-651, 2002.
(DOI: 10.1006/bbrc.2002.6714,   PubMed: 11922615)
16. Keisuke Ishizawa, Masanori Yoshizumi, Koichiro Tsuchiya, Eiko Takishita, Yutaka Nakaya, Kazuhiro Kishi, Yousuke Ebina, Hitoshi Houchi, Kazuo Minakuchi and Toshiaki Tamaki :
Effects of losartan in combination with or without exercise on insulin resistance in Otsuka Long-Evans Tokushima Fatty rats.,
European Journal of Pharmacology, Vol.430, No.2-3, 359-367, 2001.
(DOI: 10.1016/S0014-2999(01)01405-4,   PubMed: 11711055,   Elsevier: Scopus)
17. Charles W Heilig, Jeffery I Kreisberg, Svend Freytag, Takashi Murakami, Yousuke Ebina, Lirong Guo, Kathleen Heilig, Robert Loberg, Xuan Qu, Ying Jin, Douglas Henry and Frank C. Brosius3rd :
Antisense GLUT-1 protects mesangial cells from glucose induction of GLUT-1 and fibronectin expression.,
American Journal of Physiology, Renal Physiology, Vol.280, No.4, F657-F666, 2001.
(PubMed: 11249857,   Elsevier: Scopus)
18. Kazuaki Yoshizato, Tetsuya Shiotani, Noboru Furukawa, Tetsuya Taguchi, Hiroyuki Motoshima, Tetsushi Toyanaga, Yoshiaki Hirashima, Junji Kawashima, Yousuke Ebina, Motoaki Shichiri and Eiichi Araki :
Identification of a cis-acting element and a novel trans-acting factor of the human insulin receptor gene in HepG2 and rat liver cells.,
Biochemical and Biophysical Research Communications, Vol.280, No.2, 428-434, 2001.
(DOI: 10.1006/bbrc.2000.4140,   PubMed: 11162534)
19. Kazuhiro Kishi, Tomoyuki Yuasa, Asako Minami, Mizuki Yamada, Akifumi Hagi, Hideki Hayashi, Bruce E. Kemp, Lee A. Witters and Yousuke Ebina :
AMP-Activated protein kinase is activated by the stimulations of G(q)-coupled receptors.,
Biochemical and Biophysical Research Communications, Vol.276, No.1, 16-22, 2000.
(DOI: 10.1006/bbrc.2000.3417,   PubMed: 11006075,   Elsevier: Scopus)
20. Wang Lihong, Hideki Hayashi, Kazuhiro Kishi, Luping Huang, Akifumi Hagi, Keisuke Tamaoka, Phillip T Hawkins and Yousuke Ebina :
Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase.,
The Biochemical Journal, Vol.345, No.Pt 3, 543-555, 2000.
(PubMed: 10642513)
21. Satoshi Noda, Kazuhiro Kishi, Tomoyuki Yuasa, Hideki Hayashi, Tetuso Ohnishi, Ikuko Miyata, Hiromu Nishitani and Yousuke Ebina :
Overexpression of wild-type Akt1 promoted insulin-stimulated p70S6 kinase (p70S6K) activity and affected GSK3 beta regulation, but did not promote insulin-stimulated GLUT4 translocation or glucose transport in L6 myotubes.,
The Journal of Medical Investigation : JMI, Vol.47, No.1-2, 47-55, 2000.
(Tokushima University Institutional Repository: 25669,   PubMed: 10740979)
22. Akifumi Hagi, Hideki Hayashi, Kazuhiro Kishi, Wang Lihong and Yousuke Ebina :
Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose transporter type 1 (GLUT1) translocation in Chinese hamster ovary (CHO) cells stably expressing fMLP or PAF receptor.,
The Journal of Medical Investigation : JMI, Vol.47, No.1-2, 19-28, 2000.
(Tokushima University Institutional Repository: 25668,   PubMed: 10740976)
23. Jin-Zhong Zhang, Hideki Hayashi, Yousuke Ebina, Rainer Prohaska and Faramarz Ismail-Beigi :
Association of stomatin (band 7.2b) with Glut1 glucose transporter.,
Archives of Biochemistry and Biophysics, Vol.372, No.1, 173-178, 1999.
(DOI: 10.1006/abbi.1999.1489,   PubMed: 10562431)
24. Atsunori Ueyama, Karen L Yaworsky, Qinghua Wang, Yousuke Ebina and Amira Klip :
GLUT-4myc ectopic expression in L6 myoblasts generates a GLUT-4-specific pool conferring insulin sensitivity.,
The American Journal of Physiology, Vol.277, No.3 Pt 1, E572-E578, 1999.
(PubMed: 10484371)
25. Yoshihiko Asahi, Hideki Hayashi, Wang Lihong and Yousuke Ebina :
Fluoromicroscopic detection of myc-tagged GLUT4 on the cell surface. Co-localization of the translocated GLUT4 with rearranged actin by insulin treatment in CHO cells and L6 myotubes.,
The Journal of Medical Investigation : JMI, Vol.46, No.3-4, 192-199, 1999.
(Tokushima University Institutional Repository: 23732,   PubMed: 10687315)
26. Lihong Wang, Hideki Hayashi and Yousuke Ebina :
Transient effect of platelet-derived growth factor on GLUT4 translocation in 3T3-L1 adipocytes.,
The Journal of Biological Chemistry, Vol.274, No.27, 19246-19253, 1999.
(DOI: 10.1074/jbc.274.27.19246,   PubMed: 10383432)
27. Oleg V Chaika, Nina Chaika, Deanna J Volle, Hideki Hayashi, Yousuke Ebina, Ling-Mei Wang, Jacalyn H Piece and Robert E Lewis :
Mutation of tyrosine 960 within the insulin receptor juxtamembrane domain impairs glucose transport but does not inhibit ligand-mediated phosphorylation of insulin receptor substrate-2 in 3T3-L1 adipocytes.,
The Journal of Biological Chemistry, Vol.274, No.17, 12075-12080, 1999.
(DOI: 10.1074/jbc.274.17.12075,   PubMed: 10207032)
28. Zayna Khayat, Theodoros Tsakiridis, Atsunori Ueyama, Romel Somwar, Yousuke Ebina and Klip Amira :
Rapid stimulation of glucose transport by mitochondrial uncoupling depends in part on cytosolic Ca2+ and cPKC.,
The American Journal of Physiology, Vol.275, No.6 Pt 1, C1487-1497, 1998.
(PubMed: 9843710)
29. David Lauro, Yoshiaki Kido, Arthur L Castle, Mary-Jane Zarnowski, Hideki Hayashi, Yousuke Ebina and Domenico Accili :
Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue.,
Nature Genetics, Vol.20, No.3, 294-298, 1998.
(DOI: 10.1038/3112,   PubMed: 9806552)
30. Takanobu Imanaka, Hideki Hayashi, Kazuhiro Kishi, Kazuo Ishi, Osamu Hazeki, Toshiaki Katada and Yousuke Ebina :
Reconstitution of insulin signaling pathways in rat 3Y1 cells lacking insulin receptor and insulin receptor substrate-1. Evidence that activation of Akt is insufficient for insulin-stimulated glycogen synthesis or glucose uptake in rat 3Y1 cells.,
The Journal of Biological Chemistry, Vol.273, No.39, 25347-25355, 1998.
(DOI: 10.1074/jbc.273.39.25347,   PubMed: 9738001)
31. Ichiro Yokota, Hideki Hayashi, Junko Matsuda, Etsuo Naito, Michinori Ito, Yousuke Ebina and Yasuhiro Kuroda :
Effect of growth hormone on the translocation of GLUT4 and its relation to insulin-like and anti-insulin action.,
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Vol.1404, No.3, 451-456, 1998.
(DOI: 10.1016/S0167-4889(98)00077-9,   PubMed: 9739173)
32. Qinghua Wang, Zayna Khayat, Kazuhiro Kishi, Yousuke Ebina and Amira Klip :
GLUT4 translocation by insulin in intact muscle cells: detection by a fast and quantitative assay.,
FEBS Letters, Vol.427, No.2, 193-197, 1998.
(DOI: 10.1016/S0014-5793(98)00423-2,   PubMed: 9607310)
33. Hiroyuki Sano, Takayuki Higashi, Kenshi Matsumoto, Jukka Melkko, Yoshiteru Jinnouchi, Kazuyoshi Ikeda, Yousuke Ebina, Hideichi Makino, Brad Smedsrod and Seikoh Horiuchi :
Insulin enhances macrophage scavenger receptor-mediated endocytic uptake of advanced glycation end products.,
The Journal of Biological Chemistry, Vol.273, No.15, 8630-8637, 1998.
(DOI: 10.1074/jbc.273.15.8630,   PubMed: 9535837)
34. Kazuhiro Kishi, Naoko Muromoto, Yutaka Nakaya, Ikuko Miyata, Akifumi Hagi, Hideki Hayashi and Yousuke Ebina :
Bradykinin directly triggers GLUT4 translocation via an insulin-independent pathway.,
Diabetes, Vol.47, No.4, 550-558, 1998.
(DOI: 10.2337/diabetes.47.4.550,   PubMed: 9568686,   Elsevier: Scopus)
35. Nitzan Kozlovsky, Assaf Rudich, Ruth Potashnik, Yousuke Ebina, Takashi Murakami and Nava Bashan :
Transcriptional activation of the Glut1 gene in response to oxidative stress in L6 myotubes.,
The Journal of Biological Chemistry, Vol.272, No.52, 33367-33372, 1997.
(DOI: 10.1074/jbc.272.52.33367,   PubMed: 9407130)
36. Lihong Wang, Naoko Muromoto, Hideki Hayashi, Yasumasa Mitani, Hisanori Uehara, Keisuke Izumi and Yousuke Ebina :
Hyperinsulinemia but no diabetes in transgenic mice homozygously expressing the tyrosine kinase-deficient human insulin receptor.,
Biochemical and Biophysical Research Communications, Vol.240, No.2, 446-451, 1997.
(DOI: 10.1006/bbrc.1997.7677,   PubMed: 9388499)
37. Kazuhiro Kishi, Hideki Hayashi, Lihong Wang, Seika Kamohara, Keisuke Tamaoka, Takao Shimizu, Fumitaka Ushikubi, Shuh Narumiya and Yousuke Ebina :
Gq-coupled receptors transmit the signal for GLUT4 translocation via an insulin-independent pathway.,
The Journal of Biological Chemistry, Vol.271, No.43, 26561-26568, 1996.
(PubMed: 8900127)
38. Mikio Todaka, Hideki Hayashi, Takanobu Imanaka, Yasumasa Mitani, Seika Kamohara, Kazuhiro Kishi, Keisuke Tamaoka, Fumihiko Kanai, Motoaki Shichiri, Narito Morii, Shuh Narumiya and Yousuke Ebina :
Roles of insulin, guanosine 5'-[gamma-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation.,
The Biochemical Journal, Vol.315, No.Pt 3, 875-882, 1996.
(PubMed: 8645171)
39. Lihong Wang, Hideki Hayashi, Yasumasa Mitani, Kazuo Ishii, Tetsuo Ohnishi, Yasuharu Niwa, Hiroshi Kido and Yousuke Ebina :
Cloning of a cDNA encoding a 190-kDa insulin receptor substrate-1-like protein of simian COS cells.,
Biochemical and Biophysical Research Communications, Vol.216, No.1, 321-328, 1995.
40. Masaharu Kan, Fumihiko Kanai, Mitsuru Iida, Hideaki Jinnouchi, Mikio Todaka, Takanobu Imanaka, Kimio Ito, Yasuhiko Nishioka, Tetsuo Ohnishi, Seika Kamohara, Hideaki Hayashi, Takashi Murakami, Susumu Kagawa, Hiroyuki Sano, Naotake Hashimoto, Sho Yoshida, Hideichi Makino and Yousuke Ebina :
Frequency of Mutations of Insulin Receptor Gene in Japanese Patients with NIDDM,
Diabetes, Vol.44, No.9, 1081-1086, 1995.
(DOI: 10.2337/diab.44.9.1081,   PubMed: 7657032)
41. Kazuo Ishii, Hideki Hayashi, Mikio Todaka, Seika Kamohara, Fumihiko Kanai, Hideaki Jinnouchi, Lihong Wang and Yousuke Ebina :
Possible domains responsible for intracellular targeting and insulin-dependent translocation of glucose transporter type 4.,
The Biochemical Journal, Vol.309, No.Pt 3, 813-823, 1995.
(PubMed: 7543750)
42. Seika Kamohara, Hideki Hayashi, Mikio Todaka, Fumihiko Kanai, Kazuo Ishii, Takanobu Imanaka, Jaime A Escobedo, Lewis T Williams and Yousuke Ebina :
Platelet-derived growth factor triggers translocation of the insulin-regulatable glucose transporter (type 4) predominantly through phosphatidylinositol 3-kinase binding sites on the receptor.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.92, No.4, 1077-1081, 1995.
(PubMed: 7862637)
43. Kazuo Ishii, Seika Kamohara, Hideki Hayashi, Mikio Todaka, Fumihiko Kanai, Takanobu Imanaka and Yousuke Ebina :
Epidermal growth factor triggers the translocation of insulin-responsive glucose transporter (GLUT4).,
Biochemical and Biophysical Research Communications, Vol.205, No.1, 857-863, 1994.
(DOI: 10.1006/bbrc.1994.2743,   PubMed: 7999123)
44. Mikio Todaka, Toshihiko Nishiyama, Takashi Murakami, Seiichiro Saito, Kimio Ito, Fumihiko Kanai, Masaharu Kan, Kazuo Ishii, Hideki Hayashi, Motoaki Shichiri and Yousuke Ebina :
The role of insulin in activation of two enhancers in the mouse GLUT1 gene.,
The Journal of Biological Chemistry, Vol.269, No.46, 29265-29270, 1994.
(PubMed: 7961896)
45. Toshihiko Nishiyama, Tetsuya Shirotani, Takashi Murakami, Fumio Shimada, Mikio Todaka, Seiichiro Saito, Hideki Hayashi, Yoshihiko Noma, Kenji Shima, Hideichi Makino, Motoaki Shichiri, Jun-ichi Miyazaki, Ken-ichi Yamamura and Yousuke Ebina :
Expressing of the gene encoding the tyrosine kinase-deficient human insulin receptor in transgenic mice,
Gene, Vol.141, No.2, 187-192, 1994.
(PubMed: 8163187)
46. Hiroshi Suzuki, Koji Kishimoto, Tanihiro Yoshimoto, Shozo Yamamoto, Fumihiko Kanai, Yousuke Ebina, Akira Miyatake and Tadashi Tanabe :
Site-directed mutagenesis studies on the iron-binding domain and the determinant for the substrate oxygenation site of porcine leukocyte arachidonate 12-lipoxygenase.,
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1210, No.3, 308-316, 1994.
(DOI: 10.1016/0005-2760(94)90234-8,   PubMed: 8305485,   Elsevier: Scopus)
47. 吉本 谷博, Hiroshi Suzuki, Koji Kishimoto, 尚三 山本, 金井 文彦, Yousuke Ebina, 宮武 明 and 田辺 忠 :
アラキドン酸12-リポキシゲナーゼ反応におけるヒスチジン残基の役割.,
過酸化脂質研究, Vol.17, No.1, 19, 1993.
48. Fumihiko Kanai, Kimio Ito, Hideki Hayashi, Seika Kamohara, kazuo Ishii, Taro Okada, Osamu Hazeki, Michio Ui and Yousuke Ebina :
Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase.,
Biochemical and Biophysical Research Communications, Vol.195, No.2, 762-768, 1993.
(DOI: 10.1006/bbrc.1993.2111,   PubMed: 8396927)
49. Fumihiko Kanai, Yasuhiko Nishioka, Hideki Hayashi, Seika Kamohara, Mikio Todaka and Yousuke Ebina :
Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain.,
The Journal of Biological Chemistry, Vol.268, No.19, 14523-14526, 1993.
50. Hiroshi Suzuki, Koji Kishimoto, 吉本 谷博, 山本 尚三, 金井 文彦, Yousuke Ebina, 宮武 明 and 田辺 忠 :
ブタ白血球のアラキドン酸12-リポキシゲナーゼの部位特異的変異法による解析.,
脂質生化学研究35, Vol.35, 415-418, 1993.
51. Hideki Hayashi, Yasuhiko Nishioka, Seika Kamohara, Fumihiko Kanai, Kazuo Ishii, Yasuhisa Fukui, Futoshi Shabisaki, Tadaomi Takenawa, Hiroshi Kido, Nobuhiko Katsunuma and Yousuke Ebina :
The alpha-Type 85-kDa subunit of Phosphatidylinositol 3-Kinase is Phosphorylatedat Tyrosines 368, 580, and 607 by the Insulin Receptor,
The Journal of Biological Chemistry, Vol.268, No.10, 7107-7117, 1993.
52. S Yamamoto, T Yoshimoto, Y Takahashi, Hiroshi Suzuki, T Arakawa, Koji Kishimoto, T Hada, T Oshima, J Murakami, Y Yamamoto, C Yokoyama, Yousuke Ebina, E Takahashi, S Matsuda, Y Konishi, Y Mimura and M Okuma :
Biochemical and molecular biological approaches to two types of arachidonate 12-lipoxygenase,
Journal of Lipid Mediators, Vol.6, No.1-3, 69-73, 1993.
53. Hideki Hayashi, Seika Kamohara, Yasuhiko Nishioka, Fumihiko Kanai, Noriaki Miyake, Yasuhisa Fukui, Futoshi Shibasaki, Tadaomi Takenawa and Yousuke Ebina :
Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase in vivo.,
The Journal of Biological Chemistry, Vol.267, No.31, 22575-22580, 1992.
54. Takashi Murakami, Toshihiko Nishiyama, Tetsuya Shirotani, Yasuo Shinohara, Masaharu Kan, Kazuo Ishii, Fumihiko Kanai, Shoichi Nakazuru and Yousuke Ebina :
Identification of two enhancer elements in the gene encoding the type 1 glucose transporter from the mouse which are responsive to serum, growth factor, and oncogenes.,
The Journal of Biological Chemistry, Vol.267, No.13, 9300-9306, 1992.
(PubMed: 1339457)
55. Hideki Hayashi, Noriaki Miyake, Fumihiko Kanai, Futoshi Shibasaki, Tadaomi Takenawa and Yousuke Ebina :
Phosphorylation in vitro of the 85 kDa subunit of phosphatidylinositol 3-kinase and its possible activation by insulin receptor tyrosine kinase.,
The Biochemical Journal, Vol.280, No.Pt 3, 769-775, 1991.
(PubMed: 1722393)
56. Eiichi Araki, Takashi Murakami, Tetsuya Shirotani, Fumihiko Kanai, Yasuo Shinohara, Fumio Shimada, Masataka Mori, Motoaki Shichiri and Yousuke Ebina :
A cluster of four Sp1 binding sites required for efficient expression of the human insulin receptor gene.,
The Journal of Biological Chemistry, Vol.266, No.6, 3944-3948, 1991.
(PubMed: 1995641)
57. Fumio Shimada, Masato Taira, Yoshifumi Suzuki, Naotake Hashimoto, Osamu Nozaki, Masanori Taira, Masamiti Tatibana, Yousuke Ebina, Masato Tawata, Toshimasa Onaya, Hideichi Makino and Sho Yoshida :
Insulin-resistant diabetes associated with partial deletion of insulin-receptor gene.,
The Lancet, Vol.335, No.8699, 1179-1181, 1990.
(PubMed: 1971035)
58. Masato Taira, Masanori Taira, Naotake Hashimoto, Fumio Shimada, Yoshifumi Suzuki, Azuma Kanatsuka, Fumiko Nakamura, Yousuke Ebina, Masamiti Tatibana, Hideichi Makino and Sho Yoshida :
Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor.,
Science, Vol.245, No.4913, 63-66, 1989.
(DOI: 10.1126/science.2544997,   PubMed: 2544997)
59. Tadashi Seguchi, Akihiko Yoshimura, Mayumi Ono, Satoshi Shite, Michihiro Kasahara, Yousuke Ebina, J William Rutter and Michihiko Kuwano :
Insulin receptor and altered glucose transport in a monensin-resistant mutant of Chinese hamster ovary cell.,
Journal of Cellular Physiology, Vol.139, No.2, 229-236, 1989.
(DOI: 10.1002/jcp.1041390203,   PubMed: 2715185)
60. Araki Eiichi, Fumio Shimada, H Fukushima, Masataka Mori, Shichiri Motoaki and Yousuke Ebina :
Characterization of the promoter region of the human insulin receptor gene.,
Diabetes Research and Clinical Practice, Vol.7 Suppl 1, S31-3, 1989.
(PubMed: 2806055)
61. Kaoru Murakami, Yoshihiro Amaya, Masaki Takiguchi, Yousuke Ebina and Masataka Mori :
Reconstitution of mitochondrial protein transport with purified ornithine carbamoyltransferase precursor expressed in Escherichia coli.,
The Journal of Biological Chemistry, Vol.263, No.34, 18437-18442, 1988.
(PubMed: 3056942)
62. Yoshihiro Amaya, Hiroyuki Arakawa, Masaki Takiguchi, Yousuke Ebina, Sadaki Yokota and Masataka Mori :
A noncleavable signal for mitochondrial import of 3-oxoacyl-CoA thiolase.,
The Journal of Biological Chemistry, Vol.263, No.28, 14463-14470, 1988.
(PubMed: 3049578)
63. Eiichi Araki, Fumio Shimada, Haruo Uzawa, Masataka Mori and Yousuke Ebina :
Characterization of the promoter region of the human insulin receptor gene. Evidence for promoter activity.,
The Journal of Biological Chemistry, Vol.262, No.33, 16186-16191, 1987.
(PubMed: 3680248)
64. Yousuke Ebina, Eiichi Araki, Masato Taira, Fumio Shimada, Masataka Mori, S Charles Craik, Kenneth Siddle, B Sarah Pierce, A Richard Roth and J. William Rutter :
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.84, No.3, 704-708, 1987.
65. Yasuyoshi Nishida, Mami Hata, Yasuaki Nishizuka, J William Rutter and Yousuke Ebina :
Cloning of a Drosophila cDNA encoding a polypeptide similar to the human insulin receptor precursor.,
Biochemical and Biophysical Research Communications, Vol.141, No.2, 474-481, 1986.
(DOI: 10.1016/S0006-291X(86)80197-8,   PubMed: 3099787)
66. Yousuke Ebina, Mark Edery, Leland Ellis, David Standring, Jacqueline Beaudoin, A Richard Roth and J. William Rutter :
Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.82, No.23, 8014-8018, 1985.
(PubMed: 3906655)
67. Komei Shirabe, Yousuke Ebina, Toru Miki, Teruko Nakazawa and Atsushi Nakazawa :
Positive regulation of the colicin E1 gene by cyclic AMP and cyclic AMP receptor protein.,
Nucleic Acids Research, Vol.13, No.13, 4687-4698, 1985.
68. Yousuke Ebina, Leland Ellis, Kurt Jarnagin, Marc Edery, Laszlo Graf, Eric Clauser, Jing-hsiung Ou, Frank Masiarz, W Y Kan, D I Goldfine, Richard A Roth and William J Rutter :
The Human Insulin Receptor cDNA: The structural Basis for Hormone-Activated Transmembrane Signalling,
Cell, Vol.40, No.4, 747-758, 1985.
(DOI: 10.1016/0092-8674(85)90334-4,   PubMed: 2859121)
69. Sachie Inouye, Yousuke Ebina, Atsushi Nakazawa and Teruko Nakazawa :
Nucleotide sequence surrounding transcription initiation site of xylABC operon on TOL plasmid of Pseudomonas putida.,
Proc Natl Acad Sci U S A., Vol.81, No.6, 1688-1691, 1984.
70. Toru Miki, Komei Shirabe, Yousuke Ebina and Atsushi Nakazawa :
Transcription analysis of the lexA gene of Escherichia coli: attenuation and cotranscription with the neighboring region.,
Nucleic Acids Research, Vol.12, No.2, 1203-1217, 1984.
(PubMed: 6320118)
71. Ruth Sager, Kiyoji Tanaka, Ching C Lau, Yousuke Ebina and Anthony Anisowicz :
Resistance of human cells to tumorigenesis induced by cloned transforming genes.,
Proc Natl Acad Sci U S A. 1983 Dec;80(24):7601-5., Vol.80, No.24, 7601-7605, 1983.
72. Yousuke Ebina, Yoshiyuki Takahara, Fumio Kishi, Atsushi Nakazawa and Roger Brent :
LexA protein is a repressor of the colicin E1 gene.,
The Journal of Biological Chemistry, Vol.258, No.21, 13258-13261, 1983.
(PubMed: 6355108)
73. Yousuke Ebina, Yoshiyuki Takahara, Komei Shirabe, Mamoru Yamada, Teruko Nakazawa and Atsushi Nakazawa :
Plasmid-encoded regulation of colicin E1 gene expression.,
Journal of Bacteriology, Vol.156, No.2, 487-492, 1983.
(PubMed: 6313603)
74. Yousuke Ebina and Atsushi Nakazawa :
Cyclic AMP-dependent initiation and rho-dependent termination of colicin E1 gene transcription.,
The Journal of Biological Chemistry, Vol.258, No.11, 7072-7078, 1983.
(PubMed: 6304076)
75. Chieko Nakai, Hiroyuki Kagamiyama, Mitsuhiro Nozaki, Teruko Nakazawa, Sachie Inouye, Yousuke Ebina and Atsushi Nakazawa :
Complete nucleotide sequence of the metapyrocatechase gene on the TOI plasmid of Pseudomonas putida mt-2.,
The Journal of Biological Chemistry, Vol.258, No.5, 2923-2928, 1983.
(PubMed: 6826546)
76. Fumio Kishi, Yousuke Ebina, Toru Miki, Teruko Nakazawa and Atsushi Nakazawa :
Purification and characterization of a protein from Escherichia coli which forms complexes with superhelical and single-stranded DNAs.,
The Journal of Biochemistry, Vol.92, No.4, 1059-1068, 1982.
(PubMed: 6294066)
77. Yousuke Ebina, Fumio Kishi and Atsushi Nakazawa :
Direct participation of lexA protein in repression of colicin E1 synthesis.,
Journal of Bacteriology, Vol.150, No.3, 1479-1481, 1982.
78. Mamoru Yamada, Yousuke Ebina, Takashi Miyata, Teruko Nakazawa and Atsushi. Nakazawa :
Nucleotide sequence of the structural gene for colicin E1 and predicted structure of the protein.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.79, No.9, 2827-2831, 1982.
79. Yousuke Ebina, Fumio Kishi, Toru Miki, Hiroyuki Kagamiyama, Teruko Nakazawa and Atsushi Nakazawa :
The nucleotide sequence surrounding the promoter region of colicin E1 gene.,
Gene, Vol.15, No.2-3, 119-126, 1981.
(DOI: 10.1016/0378-1119(81)90121-9,   PubMed: 6271636)
80. Toru Miki, Yousuke Ebina, Fumio Kishi and Atsushi Nakazawa :
Organization of the lexA gene of Escherichia coli and nucleotide sequence of the regulatory region.,
Nucleic Acids Research, Vol.9, No.3, 529-543, 1981.
(PubMed: 6261224)
81. Horomi Ashino-Fuse, Yousuke Ebina, Kiyoshi Sunaga and Yoshiaki Miura :
Puromycin-insensitive catabolic effect of glucocorticoid in mice.,
Cellular and Molecular Biology, Including Cyto-Enzymology, Vol.27, No.2-3, 105-111, 1981.
(PubMed: 6117374)
82. Yousuke Ebina, Fumio Kishi, Teruko Nakazawa and Atsushi Nakazawa :
Gene expression in vitro of colicin El plasmid.,
Nucleic Acids Research, Vol.7, No.3, 639-649, 1979.
(PubMed: 388345)
83. Teruko Nakazawa, Emiko Hayashi, Takeshi Yokota, Yousuke Ebina and Atsushi Nakazawa :
Isolation of TOL and RP4 recombinants by integrative suppression.,
Journal of Bacteriology, Vol.134, No.1, 270-277, 1978.
(PubMed: 418059)
84. Yousuke Ebina, Hajime Iwai, Noriko Fukui, Hidesato Otsuka and Yoshiaki Miura :
Prereplicative enzymic changes in regenerating rat liver.,
The Journal of Biochemistry, Vol.77, No.3, 641-645, 1975.
(PubMed: 168185)

Academic Paper (Unrefereed Paper):

1. 西岡 麻未子, 梅原 麻子, Toshiyuki Obata, Hiroshi Shiota, Yousuke Ebina and Seiichi Hashida :
Development of the Diabetic Risk Evaluation using Resistin and Insulin Receptor-alpha in Urine and the Application to Exercise/Nutrition Education,
Research bulletin of Tokushima Bunri University, Vol.76, 1-19, 2008.
(CiNii: 110007147051)

Academic Letter:

1. Eiichi Araki, Fumio Shimada, Motoaki Shichiri, Masataka Mori and Yousuke Ebina :
pSV00CAT: low background CAT plasmid.,
Nucleic Acids Research, Vol.16, No.4, 1627, 1988.
(PubMed: 3162302)

Review, Commentary:

1. Yousuke Ebina :
インスリンによる細胞内へのグルコース取り込み促進機構 インスリン反応性グルコーストランスポーターのトランスロケーション,
化学と生物, Vol.34, No.1, 11-12, Jan. 1996.
(CiNii: 10004765272)
2. Ichiro Yokota, 林 日出喜, Junko Matsuda, Etsuo Naito, 伊藤 道徳, Yousuke Ebina and Yasuhiro Kuroda :
Impaired Sginal transduction of insulin action in two patients with Alstrom syndrome is not associated with receptor dysfunction.,
ホルモンと臨床, Vol.43, No.9, 63-66, Sep. 1995.
(CiNii: 10007089986)
3. 平良 真人, 牧野 英一, 橋本 尚武, 岩岡 秀明, 金塚 東, 桜田 正也, 山口 卓秀, 吉田 尚, Yousuke Ebina and 島田 典生 :
ヒトインスリンレセプター遺伝子におけるRestriction Fragment Length Polymorphismの検討(第755回 千葉医学会例会・第二内科例会),
Chiba Medical Journal, Vol.64, No.4, 272, 1988.
(CiNii: 110006181622)
4. Yousuke Ebina :
インスリン受容体とその遺伝子,
Seikagaku, Vol.58, No.7, p477-482, Jul. 1986.
(CiNii: 40002015086)

Proceeding of International Conference:

1. Tomoyuki Yuasa, Hisao Nagaya, Seiichi Hashida, Umehara Asako, Ichiro Yokota, Toshiyuki Obata and Yousuke Ebina :
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.,
XI INTERNATIONAL SYMPOSIUM ON INSULIN RECEPTORS AND INSULIN ACTION, Naples, Oct. 2010.
2. S Yamamoto, T Yoshimoto, Y Takahashi, Hiroshi Suzuki, T Arakawa, Koji Kishimoto, T Oshima, GR Reddy, N Ueda, J Murakami, Y Yamamoto, C Yokoyama, Yousuke Ebina, S Matsuda, Y Konishi, Y Mimura, S Arase and M Okuma :
Mammalian lipoxygenases with special reference to arachidonate 12-lipoxygenase,
Proceedings of The Fifth Scientific Meeting of the Society for Research on Polyunsaturated Fatty Acids, Vol.1025, 7-12, Jul. 1993.
3. S Yamamoto, T Yoshimoto, Y Takahashi, H Suzuki, T Arakawa, Koji Kishimoto, T Oshima, GR Reddy, N Ueda, J Murakami, Y Yamamoto, C Yokoyama, Yousuke Ebina, S Matsuda, Y Konishi, Y Mimura, S Arase and M Okuma :
Mammalian lipoxygenases with special reference to arachidonate 12-lipoxygenase.,
5th Scientific Meeting of the Society for Research on Polyunsaturated Fatty Acid, Tokyo, Nov. 1992.
4. Hiroshi Suzuki, Koji Kishimoto, T Yoshimoto, S Yamamoto and Yousuke Ebina :
Structure on iron-binding ligands of arachidonate 12-lipoxygenase of porcine leukocyte by site-directed mutagenesis.,
The 8th International conference on Prostaglandins and Related Compounds, Montreal, Jul. 1992.

Proceeding of Domestic Conference:

1. Tomoyuki Yuasa, Munehide Matsuhisa, 橋田 誠一 and Yousuke Ebina :
可溶性インスリン受容体が担うインスリン抵抗性の可能性,
第56回日本糖尿病学会年次学術集会 特別シンポジウム3, May 2013.
2. 本島 寛之, Tomoyuki Yuasa, 堤 厚之, 井形 元維, 近藤 龍也, 河島 淳司, 松村 剛, 福永 麻希子, 前田 貴子, 川崎 修二, 花谷 聡子, 石井 規夫, 下田 誠也, Noboru Furukawa, 水流添 覚, 西川 武志, Yousuke Ebina and 荒木 栄一 :
短期血糖コントロール指標としての血中可用性インスリン受容体 -ステロイドによる糖代謝悪化を検出できるのか-,
第54回日本糖尿病学会年次学術集会, Vol.54, No.sup1, S119, May 2011.
3. 高田 浩史, 井上 眞理, 池田 幸雄, 石橋 綾子, 公文 義雄, Tomoyuki Yuasa, Yousuke Ebina and 寺田 典生 :
2型糖尿病患者における血中インスリン受容体αサブユニット濃度の検討,
第53回日本糖尿病学会年次学術集会, May 2010.
4. 本島 寛之, Tomoyuki Yuasa, 西川 武志, 下田 誠也, 近藤 龍也, 河島 淳司, 松村 剛, 後藤 理英子, 大久保 美那, 前田 貴子, 武田 佳代, 山城 武司, 川崎 修二, 堤 厚之, 石井 規夫, 久木留 大介, Noboru Furukawa, 水流添 覚, 宮村 信博, Yousuke Ebina and Seiichi Hashida :
短期血糖コントロール指標としての血中可溶性インスリン受容体αサブユニットの有用性,
第53回日本糖尿病学会年次学術集会, May 2010.
5. Asako Umehara, 平島 由絵, 吉村 英悟, 内田 悦子, 末田 浩子, 津田 とみ, Yousuke Ebina and Seiichi Hashida :
尿中成長ホルモンを指標とした運動評価の検討,
第53回日本糖尿病学会年次学術集会, May 2010.
6. 本島 寛之, 河島 淳司, 下田 誠也, 前田 貴子, 大久保 美那, 西川 武志, 宮村 信博, 荒木 栄一, Tomoyuki Yuasa and Yousuke Ebina :
血中インスリン受容体αサブユニットは血糖コントロールを反映する,
第287回 日本内科学会九州地方会例会, Nov. 2009.
7. 本島 寛之, Tomoyuki Yuasa, 河島 淳司, 下田 誠也, 前田 貴子, 久木留 大介, 大久保 美那, 榊田 光倫, Yousuke Ebina, 西川 武志 and 荒木 栄一 :
可溶性インスリン受容体αサブユニットは血糖値および血糖指標と相関する,
第47回 日本糖尿病学会九州地方会, Oct. 2009.
8. Tomoyuki Yuasa, Toshiyuki Obata, Ichiro Yokota, Eiji Okamoto, Yoshiko Kanezaki, Hiroshi Maegawa, Fumiko Hirota, Kazuhiro Kishi, Seiichi Hashida, Hisao Nagaya, Ogura Yuko, Masuda Kazuhiko, Mitsuru Matsumoto, Toshio Matsumoto, Atsunori Kashiwagi and Yousuke Ebina :
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.,
International Symposium on Diabetes - Kickoff of Hannover-Tokushima Research Communiation, Mar. 2009.
9. 河野 尚平, Katsuya Hirasaka, 加川 祥子, 中尾 玲子, Kazuaki Mawatari, Nagakatsu Harada, Yutaka Nakaya, 石堂 一巳, Yousuke Ebina, Kyoichi Kishi and Takeshi Nikawa :
Cbl-b遺伝子欠損によるマクロファージの活性化を介した耐糖能異常,
第19回分子糖尿病学シンポジウム, Dec. 2007.
10. Hiroshi Suzuki, Koji Kishimoto, 吉本 谷博, 尚三 山本, 金井 文彦, Yousuke Ebina, 宮武 明 and 田辺 忠 :
12-リポキシゲナーゼの鉄含有量に与えるヒスチジン残基部位特異的変異の影響.,
第66回日本生化学会大会, Oct. 1993.
11. 吉本 谷博, Hiroshi Suzuki, Koji Kishimoto, 尚三 山本, 金井 文彦, Yousuke Ebina, 宮武 明 and 田辺 忠 :
アラキドン酸12-リポキシゲナーゼ反応におけるヒスチジン残基の役割.,
第17回日本過酸化脂質フリ-ラジカル学会, Oct. 1993.
12. Hiroshi Suzuki, Koji Kishimoto, 吉本 谷博, 山本 尚三, 金井 文彦, Yousuke Ebina, 宮武 明 and 田辺 忠 :
ブタ白血球のアラキドン酸12-リポキシゲナーゼの部位特異的変異法による解析.,
第35回日本脂質生化学研究会研究集会, Jun. 1993.
13. Hiroshi Suzuki, Koji Kishimoto, 吉本 谷博, 尚三 山本 and Yousuke Ebina :
ブタ白血球の 12-リポキシゲナーゼの鉄結合部位に関する検討.,
第65回日本生化学会大会(本人口頭), Oct. 1992.
14. Hiroshi Suzuki, Koji Kishimoto, 吉本 谷博, 尚三 山本 and Yousuke Ebina :
12-リポキシゲナーゼへの酸素添加部位を決定するアミノ酸残基の検索.,
第65回日本生化学会大会, Oct. 1992.

Et cetera, Workshop:

1. Keiji Uchiyama and Yousuke Ebina :
Functional roles of TUG and p97/VCP in Glut4 trafficking.,
第34回分子生物学会年会, 4T14a-3, Dec. 2011.
2. Keiji Uchiyama and Yousuke Ebina :
Functional roles of TUG and p97/VCP in Glut4 trafficking.,
第34回分子生物学会年会, 3P-0673, Dec. 2011.
3. Keiji Uchiyama and Yousuke Ebina :
Role of BIG2, a Guanine-Nucleotide Exchanging Factor for ADP-Ribosylation Factors, in Insulin-Regulated Glucose Transporter Translocation,
第32回 日本分子生物学会年会, 168, Dec. 2009.
4. Tomoyuki Yuasa, Toshiyuki Obata, Ichiro Yokota, 岡本 英治, Hisao Nagaya, Seiichi Hashida, 前川 聡, Atsunori kasiwagi, Mitsuru Matsumoto, Toshio Matsumoto, Kazuhiro Kishi and Yousuke Ebina :
可溶性インスリン受容体細胞外ドメイン(sIRα)は高血糖に相関して血中濃度が高まる,
第7回 1型糖尿病研究会, Nov. 2009.
5. Tomoyuki Yuasa, Seiji Yano, Yasuhiko Nishioka, Yoshiaki Kubo, Masayuki Takahashi, Hiroyoshi Nakatsuji, Hisao Nagaya, Hiro-omi Kanayama, Seiji Arase, Saburo Sone and Yousuke Ebina :
Soluble insulin receptor ectodomain in the plasma is a possible broad-spectrum tumor marker,
第68回 日本癌学会学術総会記事, 450, Oct. 2009.
6. Tomoyuki Yuasa, Toshiyuki Obata, Seiji Yano, 岡本 英治, Yasuhiko Nishioka, Yoshiaki Kubo, Masayuki Takahashi, Hiroyoshi Nakatsuji, Hisao Nagaya, Hiro-omi Kanayama, Seiji Arase, Saburo Sone and Yousuke Ebina :
Soluble insulin receptor ectodomain level was elevated in the plasma of cancer patients,
第29回 日本分子腫瘍マーカー研究会 プログラム, 70-71, Sep. 2009.
7. 本島 寛之, 西川 武志, Tomoyuki Yuasa, 河島 淳司, 後藤 理英子, 小野 薫, 花谷 聡子, 木下 博之, 川崎 修二, 堤 厚之, 児島 協, 松村 剛, 近藤 龍也, 宮村 信博, Yousuke Ebina and 荒木 栄一 :
血中インスリン受容体αサブユニット量は血糖コントロール指標となりうるか?,
第52回 日本糖尿病学会年次学術集会, Vol.52, No.1, S-294, May 2009.
8. Tomoyuki Yuasa, Toshiyuki Obata, Ichiro Yokota, Eiji Okamoto, Yoshiko Kanezaki, Hiroshi Maegawa, Fumiko Hirota, Kazuhiro Kishi, Seiichi Hashida, Hisao Nagaya, Ogura Yuko, Masuda Kazuhiko, Mitsuru Matsumoto, Toshio Matsumoto, Atsunori Kashiwagi and Yousuke Ebina :
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.,
The 1st Insulin Resistance in Metabolic Disease Forum, Aug. 2008.
9. 西岡 麻未子, 梅原 麻子, Toshiyuki Obata, Hiroshi Shiota, Yousuke Ebina and Seiichi Hashida :
尿および乾燥ろ紙血による糖尿病リスク評価法の構築 1)レジスチン,2)遊離インスリン受容体α,
第49回 日本生化学会中国・四国支部例会, Vol.80, No.7, 689, May 2008.
10. Yousuke Ebina :
Effects of Glucocorticoid on Amino Acids and Protein Metabolism,
Chiba Medical Journal, Vol.53, No.3, 77-83, Jun. 1977.
(CiNii: 110006443840)

Patent:

1. 岡本 英治, Yousuke Ebina and Toshiyuki Obata : インスリンレセプターαサブユニットの測定方法, 2009-297228 (Dec. 2009), 2010-145409 (Jul. 2010), 4530286 (Jun. 2010).
2. Yousuke Ebina, Toshiyuki Obata and Seiichi Hashida : インスリン受容体αサブユニットの測定試薬, 2007-253814 (Sep. 2007), 2009-085685 (Apr. 2009), .
3. Yousuke Ebina and Toshiyuki Obata : トランスジェニック非ヒト動物, 2007-121974 (May 2007), 2008-271913 (Nov. 2008), .
4. 岡本 英治, Yousuke Ebina and Toshiyuki Obata : Methods for Measuring the Insulin Receptor Alpha Subunit, PCT/JP2004/005412 (Apr. 2004), WO2004/097414 (Feb. 2006), 1624305 (Jun. 2010).

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Is insulin inactivated by the binding with serum soluble insulin receptor(sIR)? (Project/Area Number: 23659156 )
  • インスリン受容体過剰発現を用いた糖尿病の未来治療の試み (Project/Area Number: 21659080 )
  • Molecular mechanisms of Insulin signal transduction and diabetes mellitus (Project/Area Number: 20390095 )
  • Molecular mechanisms of insulin signal transduction and diabetes mellitus (Project/Area Number: 18390104 )
  • インスリン受容体細胞内ドメインは転写因子となりうるのか? (Project/Area Number: 17659085 )
  • Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes (Project/Area Number: 17590269 )
  • Molecular mechanisms of insulin signal transduction and diabetes mellitus (Project/Area Number: 16390097 )
  • APSノックアウトマウスは肥満によるインスリン抵抗性を回避できる (Project/Area Number: 16046215 )
  • ヒト血清中に可溶性インスリンレセプターは存在するか? (Project/Area Number: 15659079 )
  • Elucidation of the molecular mechanisms of insulin transduction using APS knockout mice (Project/Area Number: 15590249 )
  • Crystallization and structural analysis of the human insulin receptor (Project/Area Number: 15570099 )
  • Mechanism of voluntary exercise and effect of exercise training on life-style related disease studied using a line of rats for high levels of voluntary wheel running (Project/Area Number: 15500448 )
  • Molecular mechanisms of insulin signal transduction and diabetes mellitus (Project/Area Number: 14370045 )
  • PDGF投与により血糖値が下がるマウスを作れるか? (Project/Area Number: 13877018 )
  • New cDNAs and proteins phosphorylated by insulin using proteome analysis (Project/Area Number: 13680691 )
  • Molecular mechanisms of glucose uptake by insulin-independent pathway (Project/Area Number: 13670144 )
  • Development of a drug for diabetes using human genome information (Project/Area Number: 13557011 )
  • II型糖尿病の遺伝要因のゲノム的解析と分子病態の解明 (Project/Area Number: 13204065 )
  • インスリンは血中グルコース濃度を下げることのできる唯一のホルモンなのか? (Project/Area Number: 12878118 )
  • Molecular mechanisms of insulin signal transduction and diabetas mellitus (Project/Area Number: 12470027 )
  • II型糖尿病の遺伝要因のゲノム的解析と分子病態の解明 (Project/Area Number: 12204082 )
  • 肝臓におけるインスリン作用不全がII型糖尿病発症の真の原因か? (Project/Area Number: 11877028 )
  • 肝細胞増殖因子受容体(c-Met)を介するシグナル伝達の分子機構 (Project/Area Number: 07273108 )
  • インスリンシグナル伝達転換マウスの作製 (Project/Area Number: 10878097 )
  • Development of a simple screening system for the discovery of a new drug for diabetes (Project/Area Number: 10557019 )
  • Molecular mechanisms of insulin signal transduction and diabetes mellitus (Project/Area Number: 10470032 )
  • インスリン受容体とその作用メカニズムの解析 (Project/Area Number: 10169246 )
  • myc-tagを用いたインスリン反応性グリコーストランスポーターの構造と機能解析 (Project/Area Number: 08878091 )
  • Development of a simple screening system for the discovery of a new drug for diabetes (Project/Area Number: 08558074 )
  • Molecular mechanisms of insulin signal transduction and diabetes mellitus (Project/Area Number: 08457050 )
  • グルコーストランスポーターの構造・機能相関 (Project/Area Number: 08268238 )
  • インスリンシグナル伝達における蛋白質高次構造認識機構 (Project/Area Number: 07268215 )
  • インスリン作用とGTP結合蛋白質 (Project/Area Number: 07256211 )
  • Molecular mechanisms of insulin signal transduction and diabetes mellitus (Project/Area Number: 06454178 )
  • インスリンシグナル伝達における蛋白質高次構造認識機構 (Project/Area Number: 06276213 )
  • インスリン作用とGTP結合蛋白質 (Project/Area Number: 06264213 )
  • グルコーストランスポーターの細胞内局在変化の分子メカニズムとインスリン作用 (Project/Area Number: 06248221 )
  • インスリン作用とGTP結合蛋白質 (Project/Area Number: 05271212 )
  • インスリンレセプター遺伝子異常と糖尿病 (Project/Area Number: 05253214 )
  • グルコーストランスポーターの細胞内局在変化の分子メカニズムとインスリン作用 (Project/Area Number: 05252225 )
  • インスリンレセプター遺伝子異常と糖尿病 (Project/Area Number: 04260217 )
  • ヒト異常インスリン受容体遺伝子導入による糖尿病モデルマウスの作製 (Project/Area Number: 04206203 )
  • 生体受容体を機能性材料として開発するための基礎的研究 (Project/Area Number: 04205108 )
  • Molecular mechanisms of insulin signal transduction and its disorder (Project/Area Number: 03454161 )
  • インスリンレセプタ-遺伝子異常と糖尿病 (Project/Area Number: 03265210 )
  • インスリン刺激によるグルコ-ストランスポ-タ-の細胞内局在変化の分子メカニズム (Project/Area Number: 03264214 )
  • ヒト異常インスリン受容体遺伝子導入による糖尿病モデルマウスの作製 (Project/Area Number: 03206204 )
  • 生体受容体を機能材料として開発するための基礎的研究 (Project/Area Number: 03205097 )
  • Establishment of a simple diagnostic method for the detection of mutations of insulin receptor gene in Non-Insulin Dependent Diabetes Mellitus (Project/Area Number: 02557017 )
  • Protein-tyrosine phosphorylation and its biological significance (Project/Area Number: 02304034 )
  • ヒト異常インスリン受容体遺伝子導入による糖尿病モデルマウスの作製 (Project/Area Number: 02206202 )
  • 生体受容体を機能材料として開発するための基礎的研究 (Project/Area Number: 02205094 )
  • 細胞増殖シグナルによるグルコ-ストランスポ-タ-動的変化の分子機構 (Project/Area Number: 02152082 )
  • 細胞増殖シグナルの伝達・発現とその制御 (Project/Area Number: 02151080 )
  • 細胞増殖シグナルの発現・伝達とその制御 (Project/Area Number: 03151075 )
  • 3T3-L1線維芽細胞から脂肪細胞への分化誘導因子の分離と精製 (Project/Area Number: 01654513 )
  • インスリンシグナル伝達機構におけるGTP結合蛋白質の役割 (Project/Area Number: 01641527 )
  • ヒト異常インスリン受容体遺伝子導入による糖尿病モデルマウスの作製 (Project/Area Number: 01619504 )
  • 生体情報伝達機能の発現と新機能材料の設計 (Project/Area Number: 01604008 )
  • Structure and Function of Insulin Receptor, its Gene Expression and its Signal Transduction Mechanism (Project/Area Number: 01480148 )
  • 細胞増殖因子受容体チロシンキナーゼによる細胞増殖の制御機構 (Project/Area Number: 01015072 )
  • 細胞増殖シグナルの伝達とその制御 (Project/Area Number: 01010083 )
  • 生体情報伝達機能の発現機構と新機能材料の設計 (Project/Area Number: 63604008 )
  • Analysis of Insulin Receptor Gene in Insulin Resistant Diabetes (Project/Area Number: 63570523 )
  • 細胞増殖因子受容体チロシンキナーゼ細胞増殖の制御機構 (Project/Area Number: 63015073 )
  • 細胞増殖制御系におけるシグナル伝達機構 (Project/Area Number: 63010019 )
  • 新しい機能をもつ受容体作製の基礎的研究 (Project/Area Number: 62604596 )
  • Development of DNA diagnosis of urea cycle diseases and diabetes due to insulin receptor abnormality (Project/Area Number: 61870019 )
  • Structure and the regulation of the gene expression of the human insulin receptor gene and its abnormalities (Project/Area Number: 61480131 )
  • Structures, Expression and their Desorders of the Genes for Mitochondrial Proteins (Project/Area Number: 61480123 )
  • 核支配ミトコンドリア蛋白質遺伝子の構造と発現 (Project/Area Number: 61228014 )
  • Search by Researcher Number (00112227)