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Research

Field of Study

○ 薬品合成化学

Subject of Study

○ 生物有機化学 (antibiotics, DNA, chemistry, synthesis) (制がん抗生物質の化学的研究，DNA切断活性物質の分子設計と合成，生理活性天然物の構造と機能)

Book / Paper

Academic Paper (Judged Full Paper):

1. Hisao Nemoto, Rujiani Ma, Tomoyuki Kawamura, Kenji Yatsuzuka, Masaki Kamiya and Masayuki Shibuya :
One-pot Synthesis of alpha-Siloxyesters Using a Silylated Masked Acyl Cyanide,
Synthesis, No.23, 3819-3827, 2008.
(DOI: 10.1055/s-0028-1083219)
2. Hisao Nemoto, Rujiani Ma, Hideki Moriguchi, Tomoyuki Kawamura, Masaki Kamiya and Masayuki Shibuya :
Direct One-pot Synthesis of alpha-Siloxy-Weinreb Amides from Aldehydes,
The Journal of Organic Chemistry, Vol.72, No.25, 9850-9853, 2007.
(DOI: 10.1021/jo701859a,   PubMed: 17988149)
3. Hisao Nemoto, Hideki Moriguchi, Rujian Ma, Tomoyuki Kawamura, Masaki Kamiya and Masayuki Shibuya :
Highly diastereoselective nucleophilic addition reactions of masked acyl cyanide reagents to tert-butanesulfiminides,
Tetrahedron: Asymmetry, Vol.18, No.3, 383-389, 2007.
(DOI: 10.1016/j.tetasy.2007.01.032,   Elsevier: Scopus)
4. Hisao Nemoto, Rujian Ma, Tomoyuki Kawamura, Masaki Kamiya and Masayuki Shibuya :
Synthesis of alpha-Amino Acid Precursors Directly from Aldehydes using Masked Acyl Cyanide Reagents and N,O-Dialkylated Hydroxylamines,
The Journal of Organic Chemistry, Vol.71, No.16, 6038-6043, 2006.
(DOI: 10.1021/jo0607515,   PubMed: 16872186)
5. Hisao Nemoto, Tmoaki Kawano, Nobuo Ueji, Nobutaka Sakamoto, Takaaki Araki, Norikazu Miyoshi, Ichiro Suzuki and Masayuki Shibuya :
Synthesis of a water-soluble molecular tweezer and a recognition study in an aqueous media,
Tetrahedron Letters, Vol.46, No.4, 551-553, 2005.
(DOI: 10.1016/j.tetlet.2004.12.002)
6. Ichiro Suzuki, Shinsaku Uno, Yuko Tsuchiya, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Synthesis and DNA damaging ability of enediyne model compounds possessing photo-triggering devices,
Bioorganic & Medicinal Chemistry Letters, Vol.14, No.11, 2959-2962, 2004.
(DOI: 10.1016/j.bmcl.2004.02.096,   PubMed: 15125968)
7. Ichiro Suzuki, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Synthesis and DNA damaging ability of enediyne polyamine conjugates,
Tetrahedron Letters, Vol.45, No.9, 1955-1959, 2004.
(DOI: 10.1016/j.tetlet.2003.12.139)
8. Ichiro Suzuki, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Developments of Enediyne Model Compounds Generating Biradicals with an Enhanced Radical Character Regulation of Triggering Devices,
Heterocycles, Vol.62, No.1, 503-519, 2004.
(CiNii: 1520573329872209792,   Elsevier: Scopus)
9. Hisao Nemoto, Hiroe Tsutsumi, Satomi Yuzawa, Xian Peng, Weihui Zhong, Jun Xie, Norikazu Miyoshi, Ichiro Suzuki and Masayuki Shibuya :
Highly efficient chiral resolution and determination of absolute configuration of 2-alkanols by using a cyclopenta[b]furan derivative.,
Tetrahedron Letters, Vol.45, No.8, 1667-1670, 2004.
(DOI: 10.1016/j.tetlet.2003.12.104,   CiNii: 1572261551645106560)
10. Ichiro Suzuki, Akira Shigenaga, Atsuo Manabe, Hisao Nemoto and Masayuki Shibuya :
Synthesis, reactions and DNA damaging abilities of 10-membered enediyne-sulfone and related compounds,
Tetrahedron, Vol.59, No.30, 5691-5704, 2003.
(DOI: 10.1016/S0040-4020(03)00903-7)
11. Hisao Nemoto, Li Xinming, Ma Rujian, Ichiro Suzuki and Masayuki Shibuya :
A three-step preparation of MAC reagents from malononitrile,
Tetrahedron Letters, Vol.44, No.1, 73-75, 2003.
(DOI: 10.1016/S0040-4039(02)02483-8)
12. Ichiro Suzuki, Yuko Tsuchiya, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Synthesis of enediyne model compounds possessing a cyanohydrin moiety as a triggering device,
Tetrahedron Letters, Vol.43, No.38, 6779-6781, 2002.
(DOI: 10.1016/S0040-4039(02)01529-0,   Elsevier: Scopus)
13. Hisao Nemoto, Ryujian Ma, Xinming Li, Ichiro Suzuki and Masayuki Shibuya :
Synthesis of Methyl 3-Amino-2-hydoroxy-4-phenylbutanoates,Important Core Intermediates for Peptide Mimics Possessing Biological Activities,
Tetrahedron Letters, Vol.42, No.11, 2145-2147, 2001.
(DOI: 10.1016/S0040-4039(01)00120-4,   Elsevier: Scopus)
14. Ichiro Suzuki, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Acid-catalyzed Cycloaromatization of Enediyne Model Compounds via Enyne-allene Intermediates.,
Heterocycles, Vol.54, No.2, 571-576, 2001.
(CiNii: 1523669555350886528,   Elsevier: Scopus)
15. Ichiro Suzuki, Masakazu Wakayama, Akira Shigenaga, Hisao Nemoto and Masayuki Shibuya :
Synthesis of Endiyne Model Compounds Producing Toluene Diradicals Possessing a Highly Radical Character via Enyne-allene Intermediates,
Tetrahedron Letters, Vol.41, No.51, 10019-10023, 2000.
(DOI: 10.1016/S0040-4039(00)01788-3,   Elsevier: Scopus)
16. Hisao Nemoto, Rujian Ma, Ichiro Suzuki and Masayuki Shibuya :
A New One-Pot Method for the Synthesis of a-Siloxyamides from Aldehydes or ketones and Its Application to the Synthesis of (-)-Bestain,
Organic Letters, Vol.2, No.26, 4245-4247, 2000.
(PubMed: 11150210)
17. Hisao Nemoto, Rujian Ma, Hideki Moriguchi, Ichiro Suzuki and Masayuki Shibuya :
Synthesis of optically active phenylglycine derivatives from Ss-(+)-N-(benzylidene)-p-toluenesulfinamide by using Lewis acids and tert-amines,
Journal of Organometallic Chemistry, Vol.611, No.1-2, 445-448, 2000.
(DOI: 10.1016/S0022-328X(00)00478-2)
18. Hisao Nemoto, Tomoaki Kawano, Nobuo Ueji, Masahiko Bando, Masaru Kido, Ichiro Suzuki and Masayuki Shibuya :
A conformationally Reliable Spacer for Molecular Tweezers,
Organic Letters, Vol.2, No.8, 1015-1017, 2000.
(PubMed: 10804542,   Elsevier: Scopus)
19. Hisao Nemoto, Ryujian Ma, Touru Ibaragi, Ichiro Suzuki and Masayuki Shibuya :
Development of method for the preparation of a-azido-masked acyl cyanides,synthetic equivalents of N-protected C-activated a-amino acids,
Tetrahedron, Vol.56, No.11, 1463-1468, 2000.
20. Masakazu Wakayama, Ichiro Suzuki, Tadaaki Kawakami, Hisao Nemoto and Masayuki Shibuya :
Decarboxylative cycloaromatization of enediyne model compounds, --- Mechanism of the radical and ionic pathway ---,
Tetrahedron Letters, Vol.41, No.1, 95-98, 2000.
21. Hisao Nemoto, Touru Ibaragi, Masahiko Bando, Masaru Kido and Masayuki Shibuya :
Stereoselective synthesis of alkyenylated malonic diamide using masked acylcyanide,
Tetrahedron Letters, Vol.40, No.7, 1319-1322, 1999.
22. Hisao Nemoto, Junya Kikuishi, Shiho Yanagida, Tomoaki Kawano, Mizuki Yamada, Hideyoshi Harasima, Hiroshi Kiwada and Masayuki Shibuya :
Design and synthesis of cholestane derivatives bearing a cascade-type polyol and the effect of their property on a complement system in rat serum,
Bioorganic & Medicinal Chemistry Letters, Vol.9, No.2, 205-208, 1999.
23. Masayuki Shibuya, Masakazu Wakayama, Hiromi Iitsuka and Ichiro Suzuki :
Photocleavage of DNA bu the Halo Benzamide Derivatives of Oligo-N-Methylpyrrolecarboxamides,
Heterocycles, Vol.51, No.2, 325-336, 1999.
24. Kozo Shishido, Shigenori Haruna, Hiromi Iitsuka and Masayuki Shibuya :
Synthesis and Evalution of Enantiomerically Pure Azinomycin-Lexitropsin Hybrid Moleculeswith DNA-Cleaving Activity,
Heterocycles, Vol.49, No.1, 109-112, 1998.
25. Ichiro Suzuki, Yoshimitsu Naoe, Masahiko Bando, Hisao Nemoto and Masayuki Shibuya :
pH dependent cycloaromatization of enediyne model compounds via γ-oxo ketene acetal intermediates,
Tetrahedron Letters, Vol.39, No.16, 2361-2364, 1998.
26. Kozo Shishido, Shigenori Haruna, Chisato Yamamura, Hiromi Iitsuka, Hisao Nemoto, Yasuo Shinohara and Masayuki Shibuya :
Synthesis and evaluation of the hybrid molecules possessing DNA-cleaving activity,
Bioorganic & Medicinal Chemistry Letters, Vol.7, No.20, 2617-2622, 1997.
27. Masakazu Wakayama, Hisao Nemoto, Masayuki Shibuya and Yoshinori Yamamoto :
Pyridoxal-mediated cycloaromatization of an enediyne model system,
Tetrahedron Letters, Vol.37, No.30, 5397-5400, 1996.
28. Hisao Nemoto, Junya Kikuishi and Masayuki Shibuya :
A new method for the preparation of phenyl-substituted cis-enediyne from a phthalide derivative,
Chemical & Pharmaceutical Bulletin, Vol.44, No.11, 2186-2188, 1996.
29. Masayuki Shibuya, Masakazu Wakayama, Yoshimitsu Naoe, Tadaaki Kawakami, Katsuya Ishigaki, Hisao Nemoto, Hisasi Shimizu and Yoshimitsu Nagao :
Cycloaromatization of enediyne model compounds via a reaction cascade triggered by hydrolysis of the a-alkynylmalonates,
Tetrahedron Letters, Vol.37, 865-868, 1996.
30. Yoshimitsu Naoe, Junya Kikuishi, Katsuya Ishigaki, Hiromi Iitsuka, Hisao Nemoto and Masayuki Shibuya :
pH dependent cycloaromatization of enediyne model compounds via enyne-allene intermediates,
Tetrahedron Letters, Vol.36, 9165-9168, 1995.

Academic Paper (Unrefereed Paper):

1. Shigenori Haruna, Osamu Irie, Kozo Shishido, Hiromi Iitsuka, Hisao Nemoto and Masayuki Shibuya :
Development of molecules possessing DNA cleaving activity,
Tennen Yuki Kagobutsu Toronkai Koen Yoshishu 38th, 745-750, 1996.

Proceeding of International Conference:

1. Ichiro Suzuki, Akira Shigenaga, Yuki Mitami, Hisao Nemoto and Masayuki Shibuya :
Synthesis and DNA damaging ability of enediyne polyamine conjugates,
Pharmaceutical Sciences World Congress, Kyoto, May 2004.
2. Hisao Nemoto, Xian Peng, Weihui Zhong, Jun Xie, Ichiro Suzuki and Masayuki Shibuya :
Highly Efficient Chiral Resolving Agents for secondary Alcohols,
The 10th Japan-Korea Joint Symposium on Drug Design and Develoment, Tokushima, Apr. 2004.
3. Tomoyuki Kawamura, Ichiro Suzuki, Hisao Nemoto and Masayuki Shibuya :
One-pot Synthesis of alpha-amino acid derivatives from inactivated imines by using MAC reagents,
The 10th Japan-Korea Joint Symposium on Drug Design and Develoment, Tokushima, Apr. 2004.
4. Dong Ning, Ichiro Suzuki, Hisao Nemoto and Masayuki Shibuya :
Preparation of the peptide mimics by using MAC reagents and the optimization of their diastereoselectivity,
The 10th Japan-Korea Joint Symposium on Drug Design and Develoment, Tokushima, Apr. 2004.
5. Mayuko Takahashi, Ichiro Suzuki, Hisao Nemoto and Masayuki Shibuya :
Synthesis and DNA Photo-damage of Fluoroquinolone-oligo-N-methylpyrrole Conjugates,
The 10th Japan-Korea Joint Symposium on Drug Design and Develoment, Tokushima, Apr. 2004.
6. Hisao Nemoto, Rujian Ma, Xinming Li, Hideki Moriguchi, Ichiro Suzuki and Masayuki Shibuya :
A New One-pot Method for the Synthesis of (±)-Siloxy Carbony Compounds,
The 15th french-Japanese Synposium on Medicinal and Fine Chemistry, Nara, Jul. 2001.

Proceeding of Domestic Conference:

1. 川野 正記, 西野 勝, 金子 麻衣, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
高い緩和率を持つMRI造影剤として期待されるGd-DTPA誘導体の設計および合成,
日本薬学会 第124年会, Vol.30[P2]I-286, Mar. 2004.
2. 河村 知志, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
低反応性イミンを出発原料としたα-アミノエステルのOne-pot合成,
日本薬学会 第124年会, Vol.30[P1]I-193, Mar. 2004.
3. 真鍋 敦雄, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
複素環化合物の新規合成法の開発,
日本薬学会 第124年会, Vol.30[P1]I-104, Mar. 2004.
4. 髙橋 真由子, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
DNA親和性部位を有するフルオロキノロン誘導体の合成とDNA切断活性,
日本薬学会 第124年会, Vol.29[P2]I-397, Mar. 2004.
5. Akira Shigenaga, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
ポリアミン部位を有するビラジカル生成モデル化合物に関する研究,
日本薬学会 第124年会, Vol.29[P2]I-396, Mar. 2004.
6. 真鍋 敦雄, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
Myers-Saito型芳香環化反応を用いたヘテロ環化合物の新規合成法の開発,
第42回 日本薬学会·日本病院薬剤師会中国四国支部学術大会, Vol.15A13-030, Nov. 2003.
7. 髙橋 真由子, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
DNA親和性部位を有するフルオロキノロン誘導体の合成とDNA切断活性,
第42回 日本薬学会·日本病院薬剤師会中国四国支部学術大会, Vol.15A13-00, Nov. 2003.
8. Akira Shigenaga, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
DNA親和性部位を有するビラジカル生成モデル化合物に関する研究,
日本薬学会 第123年会, Vol.29[P1]I-007, Mar. 2003.
9. 荒木 崇彰, 川野 正記, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
ポリオール型水溶性増強化試薬の合成および生理活性化合物への適用,
日本薬学会 第123年会, Vol.28[P1]I-091, Mar. 2003.
10. 坂本 信敬, 寺村 和起, Hisao Nemoto and Masayuki Shibuya :
全トランス縮環型パーヒドロナフタセン骨格を基盤とする新規ホスト分子の設計·合成と分子認識能,
日本薬学会 第123年会, Vol.28[P1]I-069, Mar. 2003.
11. 鈴木 一郎, 髙橋 真由子, Hisao Nemoto and Masayuki Shibuya :
DNA 親和性部位を有するフルオロキノロン誘導体に関する研究,
日本薬学会 第123年会, Vol.28[P1]I-018, Mar. 2003.
12. Hisao Nemoto, 堤 寛恵, 由澤 智美, 森口 英記, 松本 浩二, 三宅 洋子, 鈴木 一郎, Masayuki Shibuya, 坂本 圭 and 山田 俊郎 :
シクロペンタ[b]フラン骨格を有するアセタール型光学分割剤,
第32回 複素環化学討論会, Vol.1P-47, Dec. 2002.
13. 宇野 晋策, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
光反応による脱保護をトリガーとするビラジカル生成モデルの開発,
第41回 日本薬学会·日本病院薬剤師会中国四国支部学術大会, Vol.10C10-30, Nov. 2002.
14. 崎山 誠, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
チオール類の付加反応をトリガーとするビラジカル生成モデルの開発,
第41回 日本薬学会·日本病院薬剤師会中国四国支部学術大会, Vol.10C10-20, Nov. 2002.
15. 坂本 信敬, 寺村 和起, Ichiro Suzuki, Hisao Nemoto and Masayuki Shibuya :
直方型空洞を形成する際の全トランス宿環型パーヒドロナフタセン骨格の影響,
第41回 日本薬学会·日本病院薬剤師会中国四国支部学術大会, Vol.10C10-00, Nov. 2002.
16. 荒木 崇彰, 河野 正記, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
ポリオール構造をもつ新規水溶性増強化試薬の合成とその応用,
第41回 日本薬学会·日本病院薬剤師会中国四国支部学術大会, Vol.10C09-50, Nov. 2002.
17. 浜 進, Kentaro Kogure, Satoru GOTO, Ichiro Suzuki, Akira Tokumura, Masayuki Shibuya and Kenji Fukuzawa :
トコフェロール-コハク酸によるPKCを介したNO産生促進機構,
第41回日本薬学会·日本病院薬剤師会中国四国支部学術大会, Oct. 2002.
18. 鈴木 一郎, 土屋 優子, Akira Shigenaga, Hisao Nemoto, 中馬 寛 and Masayuki Shibuya :
Ab-initio法を用いたエンジインモデル化合物の分子設計,
第24回 情報科学討論会, Nov. 2001.
19. 鈴木 一郎, Akira Shigenaga, 土屋 優子, Hisao Nemoto and Masayuki Shibuya :
炭素ビラジカルの反応性制御に基づいた低イオン性ビラジカル生成モデルの開発,
有機合成化学協会 第17回化学道場, Jul. 2001.
20. 金本 憲始, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
開環系エンジインモデル化合物の芳香環化反応,
日本薬学会 第121年会, Vol.30[PA]I-009, Mar. 2001.
21. Akira Shigenaga, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
10員環含硫エンジインモデル化合物の芳香環化合物,
日本薬学会 第121年会, Vol.30[PA]I-008, Mar. 2001.
22. 鈴木 一郎, 土屋 優子, 宇野 晋策, Hisao Nemoto, 中馬 寛 and Masayuki Shibuya :
ビラジカルの反応性制御に基づくエンジインモデル化合物の開発,
日本薬学会 第121年会, Vol.30[PA]I-007, Mar. 2001.
23. 由澤 智美, 堤 寛恵, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
新規高効率光学分割剤としての[3.3.0]-Bicyclooxaoctene,
日本化学会 第79春期年会, Vol.3H138, Mar. 2001.
24. 河野 友昭, 上路 喜生, 坂本 信敬, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
全トランス接合型パーヒドロナフタセンを有する新規水溶性Tweezers型化合物の合成,
日本化学会 第79春期年会, Vol.3H137, Mar. 2001.
25. 馬 汝建, 李 新明, 鈴木 一郎, Hisao Nemoto and Masayuki Shibuya :
MAC反応剤を用いた，β-アミノ-α-ヒドロキシエステルの高効率合成法,
日本化学会 第79春期年会, Vol.1G318, Mar. 2001.

Report:

1. Masayuki Shibuya, Hiroshi Kido, Yoshio Hayashi, Hisao Nemoto, Shigeki Sano, Koji Yasutomo, Hiroyuki Azuma, Yasuhiko Nishioka, Junji Terao, Takeshi Nikawa, Hiroaki Misawa, Shigeki Matsuo, Yoshinobu Baba, Kozo Matsumoto, Hirokazu Miyoshi and Saburo Sone :
徳島大学先端医療開発研究センター設置準備室成果報告書,
Dec. 2002.

Patent:

1. Hisao Nemoto and Masayuki Shibuya : 光学活性体の絶対配置決定剤，その製造方法及びこれを用いる光学活性体の絶対配置決定方法, 2002-244394 (2002).
2. Hisao Nemoto and Masayuki Shibuya : Preparation of bicyclooxaoctanes and bicyclooxaoctenes as optical resolving agents and method for optical resolution of alcohols using said agents, .
3. Hisao Nemoto and Masayuki Shibuya : 抱接性化合物, 2001-71283 (2002).