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Book / Paper

Book:

1. Naokatu Arakaki and Tomihiko Higuti :
"ファイバー"スーパーバイオミメティックス∼近未来創造テクノロジー∼,
NTS Inc., Tokyo, Oct. 2006.
2. Naokatu Arakaki, 蔵本 良範 and Tomihiko Higuti :
リポソーム応用の新展開 ー人工細胞の開発に向けて,
NTS Inc., Tokyo, Jun. 2005.
3. Hideyoshi Morita, Seiichi Wakaizumi, Masanori Miyata, Shuji Katsura, Kenji Mori, Nobuyoshi Nakajo, Tomihiko Higuti, Masanobu Haraguchi, Makoto Ohashi and Kenji Matsuura :
授業改善のための実例集ハンドブック,
Center for University Extension, Tokushima, Jan. 2005.
4. Kazuo Hosoi, Tomihiko Higuti, Masanori Kashimata, Rieko Arakaki, Naokatu Arakaki, Jun Tada, Keiko Tsumura, Tetsuya Akamatsu, Kyouko Takeda, Akemichi Ueno, Midori Suenaga, Yoshinobu Baba and others :
Experimental Manual for Molecular Cell Biology, 2nd Edition,
Nankodo, Tokyo, Apr. 2004.
5. 武田 京子, 姫田 敏樹 and Tomihiko Higuti :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
6. 武田 京子, 姫田 敏樹 and Tomihiko Higuti :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
7. 姫田 敏樹 and Tomihiko Higuti :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
8. 姫田 敏樹 and Tomihiko Higuti :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
9. 姫田 敏樹 and Tomihiko Higuti :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
10. Tomihiko Higuti :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
11. Tomihiko Higuti and 吉原 裕 :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
12. 吉原 裕 and Tomihiko Higuti :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
13. Tomihiko Higuti :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
14. Tomihiko Higuti and 吉原 裕 :
分子細胞生物学基礎実験法 改訂第2版,
Nankodo, Tokyo, Mar. 2004.
15. Toshiki Himeda and Tomihiko Higuti :
新ミトコンドリア学,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, Nov. 2001.
16. Naokatu Arakaki and Tomihiko Higuti :
新ミトコンドリア学,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, Nov. 2001.
17. 末永 みどり, 大脇 浩幸, Naokatu Arakaki and Tomihiko Higuti :
新ミトコンドリア学,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, Nov. 2001.
18. Tomihiko Higuti :
新ミトコンドリア学,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, Nov. 2001.
19. Tomihiko Higuti :
新ミトコンドリア学,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, Nov. 2001.
20. 前田 好正 and Tomihiko Higuti :
新ミトコンドリア学,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, Nov. 2001.
21. Tomihiko Higuti :
分子がつくるナノの不思議,
株式会社 クバプロ, Tokyo, Sep. 2000.

Academic Paper (Judged Full Paper):

1. Hirofumi Shibata, Nishitani Noriko, Yaohara Sayuri, Naokatu Arakaki, Tomihiko Higuti, Kazuyoshi Kawazoe and Kazuo Minakuchi :
Simvastatin represses translocation of Pseudomonas aeruginosa across Madin-Darby canine kidney cell monolayers,
The Journal of Medical Investigation : JMI, Vol.59, No.1,2, 186-191, 2012.
(Tokushima University Institutional Repository: 106020,   DOI: 10.2152/jmi.59.186,   PubMed: 22450007)
2. K Yoshikawa, M Ohtsu, N Kokudo, Hirofumi Shibata, Naokatu Arakaki, Tomihiko Higuti and T Hashimoto :
Phenolic constituents from the branch of Firmiana simplex.,
The Japanese Journal of Pharmacognosy, Vol.64, No.2, 102-103, 2010.
(CiNii: 110008685902)
3. Hirofumi Shibata, Tatsuro Nakano, Khasru M. Anowar Parvez, Yoshihiro Furukawa, Akio Tomoishi, Shingo Niimi, Naokatu Arakaki and Tomihiko Higuti :
Triple combinations of lower and longer alky1 gallates and oxacillin improve antibiotic synergy against methicillin-resistant Staphylococcus aureus,
Antimicrobial Agents and Chemotherapy, Vol.53, No.5, 2218-2220, 2009.
(DOI: 10.1128/AAC.00829-08,   PubMed: 19223633)
4. Hitoshi Kawazoe, kyoko Takaoka, Hirofumi Shibata, Naokatu Arakaki, Tomihiko Higuti, K Negayama, Hitoshi Houchi, Koichiro Tsuchiya and Yoshiharu Takiguchi :
Comparison of antibacterial activity of fluoroquinolones with their sucralfate-complexes against clinically-isolated bacteria,
Journal of Health Science, Vol.55, No.5, 790-795, 2009.
(DOI: 10.1248/jhs.55.790,   CiNii: 130000127968)
5. MAK Parvez, Hirofumi Shibata, Tatsuro Nakano, Shingo Niimi, Nobuo Fujii, Naokatu Arakaki and Tomihiko Higuti :
No relationship exists between PBP 2a amounts expressed in different MRSA strains obtained clinically and their beta-lactam MIC values,
The Journal of Medical Investigation : JMI, Vol.55, No.3-4, 246-253, 2008.
(Tokushima University Institutional Repository: 110867,   DOI: 10.2152/jmi.55.246,   PubMed: 18797139,   Elsevier: Scopus)
6. Kazuko Yoshikawa, Naoki Kokudo, Masami Tanaka, Tatsuro Nakano, Hirofumi Shibata, Naokatu Arakaki, Tomihiko Higuti and Toshihiro Hashimoto :
Novel abietane diterpenoids and aromatic compounds from Cladonia rangiferina and their antimicrobial activity against antibiotics resistant bacteria,
Chemical & Pharmaceutical Bulletin, Vol.56, No.1, 89-92, 2008.
(DOI: 10.1248/cpb.56.89,   PubMed: 18175983,   Elsevier: Scopus)
7. Naokatu Arakaki, Toshiyuki Kita, Hirofumi Shibata and Tomihiko Higuti :
Cell-surface H+-ATP synthase as a potential molecular target for anti-obesity drugs,
FEBS Letters, Vol.581, No.18, 3405-3409, 2007.
(DOI: 10.1016/j.febslet.2007.06.041,   PubMed: 17612527)
8. Naokatu Arakaki, Takeshi Nishihama, Akira Kohda, Hiroyuki Owaki, Reika Abe, Toshiyuki Kita, Midori Suenaga, Toshiki Himeda, Masamichi Kuwajima, Hirofumi Shibata and Tomihiko Higuti :
Regulation of mitochondrial morphology and cell survival by Mitogenin I and mitochondrial single-stranded DNA binding protein,
Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1760, No.9, 1364-1372, 2006.
(DOI: 10.1016/j.bbagen.2006.05.012,   PubMed: 16860483)
9. Hiroyuki Nakagawa, Yoshihisa Takaishi, Naonobu Tanaka, Koichiro Tsuchiya, Hirofumi Shibata and Tomihiko Higuti :
Chemical Constituents from the Peels of Citrus sudachi,
Journal of Natural Products, Vol.69, No.8, 1177-1179, 2006.
(DOI: 10.1021/np060217s,   PubMed: 16933871)
10. Naokatu Arakaki, Takeshi Nishihama, Hiroyuki Owaki, Yoshinori Kuramoto, Midori Suenaga, Eri Miyoshi, Yuka Emoto, Hirofumi Shibata, Masayuki Shono and Tomihiko Higuti :
Dynamics of mitochondria during the cell cycle,
Biological & Pharmaceutical Bulletin, Vol.29, No.9, 1962-1965, 2006.
(DOI: 10.1248/bpb.29.1962,   PubMed: 16946518)
11. F.A. Ramos, Yoshihisa Takaishi, M. Shirotori, Y. Kawaguchi, Koichiro Tsuchiya, Hirofumi Shibata, Tomihiko Higuti, T. Tadokoro and M. Takeuchi :
Antibacterial and Antioxidant Activities of Quercetin Oxidation Products from Yellow Onion (Alliu cepa) Skin,
Journal of Agricultural and Food Chemistry, Vol.54, No.10, 3551-3357, 2006.
(DOI: 10.1021/jf060251c,   PubMed: 19127724)
12. K Kondo, Yoshihisa Takaishi, Hirofumi Shibata and Tomihiko Higuti :
ILSMRs (intensifier of β-lactam-susceptibility in methicillin-resistant Staphylococcus aureus) from Tara [Caesalpinia spinosa (Molina) Kuntze],
Phytomedicine, Vol.13, No.3, 209-212, 2006.
(DOI: 10.1016/j.phymed.2004.08.001,   PubMed: 16428032)
13. Toshimasa Ochi, Hirofumi Shibata, Tomihiko Higuti, Ko-hei Kodama, Takenori Kusumi and Yoshihisa Takaishi :
Anti-Helicobacter pylori Compounds from Santalum album,
Journal of Natural Products, Vol.68, No.6, 819-824, 2005.
(DOI: 10.1021/np040188q,   PubMed: 15974602)
14. Hirofumi Shibata, Kyoko Kondo, Ryo Katsuyama, Kazuyoshi Kawazoe, Youichi Sato, Kotaro Murakami, Yoshihisa Takaishi, Naokatu Arakaki and Tomihiko Higuti :
Alkyl Gallates, Intensifiers of ß-Lactam Susceptibility in Methicillin-Resistant Staphylococcus aureus,
Antimicrobial Agents and Chemotherapy, Vol.49, No.2, 549-555, 2005.
(DOI: 10.1128/AAC.49.2.549-555.2005,   PubMed: 15673731)
15. Naokatu Arakaki, Ayano Toyofuku, Yuka Emoto, Tomoko Nagao, Yoshinori Kuramoto, Hirofumi Shibata and Tomihiko Higuti :
Induction of G1 cell-cycle arrest in human umbilical vein endothelial cells by flavone s inhibition of the ERK cascade.,
Biochemistry and Cell Biology, Vol.82, No.5, 583-588, 2004.
(DOI: 10.1139/o04-057,   PubMed: 15499387)
16. Youichi Sato, Hirofumi Shibata, Tsutomu Arai, Akira Yamamoto, Yousuke Okimura, Naokatu Arakaki and Tomihiko Higuti :
Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to β-lactam antibiotics,
International Journal of Antimicrobial Agents, Vol.24, No.3, 226-233, 2004.
(DOI: 10.1016/j.ijantimicag.2004.02.028,   PubMed: 15325425)
17. Mamoru Okasaka, Yoshihisa Takaishi, Kentaro Kogure, Kenji Fukuzawa, Hirofumi Shibata, Tomihiko Higuti, Gisho Honda, Michiho Ito, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
New Stilbene Derivatives from Calligonum leucocladum,
Journal of Natural Products, Vol.67, No.6, 1044-1046, 2004.
(DOI: 10.1021/np0304823,   PubMed: 15217293)
18. Midori Suenaga, Masamichi Kuwajima, Toshiki Himeda, Kayoko Morokami, Teruro Matsuura, Kiyokazu Ozaki, Naokatu Arakaki, Hirofumi Shibata and Tomihiko Higuti :
Identification of the up- and down-regulated genes in the heart of juvenile visceral steatosis mice,
Biological & Pharmaceutical Bulletin, Vol.27, No.4, 496-503, 2004.
(DOI: 10.1248/bpb.27.496,   PubMed: 15056854,   CiNii: 110003608793)
19. Youichi Sato, Hirofumi Shibata, Naokatu Arakaki and Tomihiko Higuti :
6,7-dihydroxyflavone dramatically intensifies the susceptibility of methicillin-resistant or -sensitive Staphylococcus aureus to beta-lactams.,
Antimicrobial Agents and Chemotherapy, Vol.48, No.4, 1357-1360, 2004.
(DOI: 10.1128/AAC.48.4.1357-1360.2004,   PubMed: 15047543)
20. Naokatu Arakaki, Tomoko Nagao, Rie NIki, Ayako Toyofuku, Hiroaki Tanaka, Yoshinori Kuramoto, Yuka Emoto, Hirofumi Shibata, Koji Magota and Tomihiko Higuti :
Possible role of cell surface H+-ATP synthase in the extracellular ATP synthesis and proliferation of human umbilical vein endothelial cells,
Molecular Cancer Research : MCR, Vol.1, No.13, 931-939, 2003.
(PubMed: 14638865,   Elsevier: Scopus)
21. Hirofumi Shibata, Chikako Shirakata, Hiromi Kawasaki, Youichi Sato, Tomomi Kuwahara, Yoshinari Ohnishi, Naokatu Arakaki and Tomihiko Higuti :
Flavone markedly affects phenotypic expression of beta-lactam resistance in methicillin-resistant Staphylococcus aureus strains isolated clinically.,
Biological & Pharmaceutical Bulletin, Vol.26, No.10, 1478-1483, 2003.
(DOI: 10.1248/bpb.26.1478,   PubMed: 14519958,   CiNii: 110003608328)
22. Kazuyoshi Kawazoe, Yoshiko Tsubouchi, Norasyikin Abdullah, Yoshihisa Takaishi, Hirofumi Shibata, Tomihiko Higuti, Hitoshi Hori and Makoto Ogawa :
Sesquiterpenoids from Artemisia gilvescens and an Anti-MRSA Compound,
Journal of Natural Products, Vol.66, No.4, 538-539, 2003.
(DOI: 10.1021/np020593m,   PubMed: 12713410)
23. Midori Suenaga, Naokatu Arakaki, Kayoko Morokami, Toshiki Himeda, Hirofumi Shibata, Masamichi Kuwajima and Tomihiko Higuti :
Functional disorders of the oxidative phosphorylation system in the heart mitochondria of mice with juvenile visceral steatosis,
Biological & Pharmaceutical Bulletin, Vol.26, No.3, 289-294, 2003.
(DOI: 10.1248/bpb.26.289,   PubMed: 12612434,   CiNii: 110003608419)
24. Tomihiko Higuti :
薬剤耐性克服のための新しい方法,
Shikoku Acta Medica, Vol.58, No.3, 107-121, 2002.
(Tokushima University Institutional Repository: 110537)
25. Yukiko Tada, Yasuhiro Shikishima, Yoshihisa Takaishi, Hirofumi Shibata, Tomihiko Higuti, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov, Ozodbek Ashurmetov and Yasukazu Ohmoto :
Coumarins and γ-pyrone derivatives from Prangos pabularia: antibacterial activity and inhibition of cytokine release,
Phytochemistry, Vol.59, No.6, 649-654, 2002.
(DOI: 10.1016/S0031-9422(02)00023-7,   PubMed: 11867097,   CiNii: 80015400321)
26. Michiko Matsuhisa, Yasuhiro Shikishima, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Hirofumi Shibata, Tomihiko Higuti, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Benzoylphloroglucinol Derivatives from Hypericum scabrum,
Journal of Natural Products, Vol.65, No.3, 290-294, 2002.
(DOI: 10.1021/np010310a,   PubMed: 11908967)
27. Akira Shibata, A. Yorimitsu, H. Ikema, K. Minami, Satoru Ueno, E. Muneyuki and Tomihiko Higuti :
Photocurrent of purple membrane adsorbed onto a thin polymer film, --- action characteristics of the local anesthetics ---,
Colloids and Surfaces B:Biointerfaces, Vol.23, No.4, 375-382, 2002.
(DOI: 10.1016/S0927-7765(01)00272-7)
28. Tomihiko Higuti, H. Shibata, Y. Sato, C. Arai, C. Shirakata and N. Arakaki :
Dramatic Induction by Flavone and its derivatives of Susceptibility to β-Lactam Antibiotics in Methicillin-Resistant Staphylococcus Aureus,
Polyphenols Communications, 127-128, 2002.
29. Kimiko Tamemoto, Yoshihisa Takaishi, Bei Chen, Kazuyoshi Kawazoe, Hirofumi Shibata, Tomihiko Higuti, Gisho Honda, Michiho Ito, Yoshio Takeda, Olimjon K. Kodzhimatov and Ozodbek Ashurmetov :
Sesquiterpenoids from the fruits of Ferula kuhistanica and antibacterial activity of the constituents of F. kuhistanica,
Phytochemistry, Vol.58, No.5, 763-767, 2001.
(DOI: 10.1016/S0031-9422(01)00307-7,   PubMed: 11672742,   Elsevier: Scopus)
30. Akira Shibata, H. Ikema, Satoru Ueno, E. Muneyuki and Tomihiko Higuti :
Alkane derivative-bacteriorhodopsin interaction: proton transport and protein structure,
Colloids and Surfaces B:Biointerfaces, Vol.22, No.1, 31-38, 2001.
(DOI: 10.1016/S0927-7765(01)00155-2,   PubMed: 11438238,   Elsevier: Scopus)
31. Naokatu Arakaki, Yumiko Ueyama, Mayumi Hirose, Toshiki Himeda, Hirofumi Shibata, Shiroh Futaki, Kouki Kitagawa and Tomihiko Higuti :
Stoichiometry of subunit e in rat liver mitochondrial H+-ATP synthase and membrane topology of its putative Ca2+-dependent regulatory region,
Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol.1504, No.2-3, 220-228, 2001.
(DOI: 10.1016/S0005-2728(00)00248-6,   PubMed: 11245786)
32. A. Shibata, K. Yamada, H. Ikema, Satoru Ueno, E. Muneyuki and Tomihiko Higuti :
Photocurrent of purple membrane adsorbed onto a thin solid film: effects of monovalent and divalent ions,
Studies in Surface Science and Catalysis, Vol.132, 635-638, 2001.
(DOI: 10.1016/S0167-2991(01)82171-6,   Elsevier: Scopus)
33. Kazuyoshi Kawazoe, Aki Yutani, Kimiko Tamemoto, Shuko Yuasa, Hirofumi Shibata, Tomihiko Higuti and Yoshihisa Takaishi :
Phenylnaphthalene Compounds from the Subterranean Part of Vitex rotundifolia and Their Antibacterial Activity Against Methicillin-Resistant Staphylococcus aureus,
Journal of Natural Products, Vol.64, No.5, 588-591, 2001.
(DOI: 10.1021/np000307b,   PubMed: 11374949)
34. Toshiki Himeda, Kayoko Morokami, Naokatu Arakaki, Hirofumi Shibata and Tomihiko Higuti :
Synchronized transcriptional gene expression of H+-ATP synthase subunits in different tissues of Fischer 344 rats of different ages,
European Journal of Biochemistry, Vol.267, No.23, 6938-6942, 2000.
(DOI: 10.1046/j.1432-1327.2000.01805.x,   PubMed: 11082207,   Elsevier: Scopus)
35. Youichi Sato, Shiho Suzaki, Takako Nishikawa, Masaru Kihara, Hirofumi Shibata and Tomihiko Higuti :
Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus.,
Journal of Ethnopharmacology, Vol.72, No.3, 483-488, 2000.
(DOI: 10.1016/S0378-8741(00)00265-8,   PubMed: 10996290)
36. Youichi Sato, H Oketani, T Yamada, K Singyouchi, T Ohtsubo, Masaru Kihara, Hirofumi Shibata and Tomihiko Higuti :
A Xanthanolide with Potent Antibacterial Activity against Methicillin-resistant Staphylococcus aureus.,
The Journal of Pharmacy and Pharmacology, Vol.49, 1042-1044, 1997.
37. Hidehiro Sangawa, Toshiki Himeda, Hirofumi Shibata and Tomihiko Higuti :
Gene expression of subunit c(P1), subunit c(P2), and oligomycin sensitivity-conferring protein may play a key role in biogenesis of H+-ATP synthase in various rat tissues,
The Journal of Biological Chemistry, Vol.272, No.9, 6034-6037, 1997.
(DOI: 10.1074/jbc.272.9.6034,   PubMed: 9038226,   Elsevier: Scopus)
38. Youichi Sato, H Oketani, K Singyouchi, T Ohtubo, Masaru Kihara, Hirofumi Shibata and Tomihiko Higuti :
Extraction and Purification of Effective Antimicrobial Constituents of Terminalia chebula RETS. against Methicillin-Resistant Staphylococcus aureus.,
Biological & Pharmaceutical Bulletin, Vol.20, 401-404, 1997.
39. Mark Prescott, Tomihiko Higuti, Phillip Nagley and Rodney J. Devenish :
The Functional Expression of a Rat cDNA Encoding OSCP in the Yeast Saccharomyces cerevisiae,
Biochemical and Biophysical Research Communications, Vol.207, No.3, 943-949, 1995.
40. Junji Ezaki, Leonhard S. Wolfe, Tomihiko Higuti, Kazumi Ishidoh and Eiki Kominami :
Specific Delay of Degradation of Mitochondrial ATP Synthase Subunit c in Late Infantile Neuronal Ceroid Lipofuscinosis (Batten Disease),
Journal of Neurochemistry, Vol.64, No.2, 733-741, 1995.
41. Tomisaburo Kakuno, Kazuo Hosoi, Tomihiko Higuti and Takekazu Horio :
Electron and proton transports in Rhodospirillum rubrum chromatophores,
The Journal of Biochemistry, Vol.74, No.6, 1193-1203, 1973.

Review, Commentary:

1. Tomihiko Higuti, Toshiki Himeda, Yuko Koto and Kayoko Morokami :
Concerted gene expression and master factor in molecular architecture of mammalian H+-ATP synthase,
In Molecular Superstructure Design and Creation (Kajiyama, T. ed.), 362-366, 1998.

Proceeding of International Conference:

1. Kawano Wataru, Hirofumi Shibata, Hikichi Kaori, Masanori Higuti, Kazuyoshi Kawazoe, Kazuo Minakuchi and Tomihiko Higuti :
Antiviral Effect of Octyl Gallate,
11th Western Pacific Congress on Chemotherapy and Infectious Diseases, 0, Taipei, Dec. 2008.
2. Kazuyoshi Kawazoe, Tubouchi Yoshiko, Abdullah Norasyikin, Yoshihisa Takaishi, Hirofumi Shibata, Tomihiko Higuti and Hitoshi Hori :
Sesquiterpenoids from Artemisia gilvescens Miq.,
International Symposium on the Chemistry of Essential Oils, Therpenes and Aromatics, 273-275, Tokushima, Oct. 2002.
3. Toshiki Himeda, Kayoko Morokami, Naokatu Arakaki, Hirofumi Shibata and Tomihiko Higuti :
Synchronized transcriptional gene expression of H+-ATP synthase subunits in different tissues of Fischer 344 rats of different ages,
The First International Symposium on Molecular Synchronization for Design of New Materials System, Tokyo, Sep. 2000.
4. Toshiki Himeda, Kayoko Morokami, Hidehiro Sangawa, Hirofumi Shibata and Tomihiko Higuti :
Gene expression of subunit c(P1), subunit c(P2), and oligomycin sensitivity conferring protein may play a key role in biogenesis of ATP synthase in various rat tissues,
17th International Congress of Biochemistry and Molecular Biology, San Francisco, Aug. 1997.
5. Hidehiro Sangawa, Toshiki Himeda and Tomihiko Higuti :
Age-Related Changes of Transcriptional Regulatory Systems of H+-ATP Synthase Subunits in Rat Tissues,
12th International Symposium of Federation of Asian and Oceanian Biochemists and Molecular Biologists. Gene Regulation of Biological Functions, Tokushima, Jul. 1996.

Proceeding of Domestic Conference:

1. 喜多 俊行, 西田 華, Naokatu Arakaki, Hirofumi Shibata and Tomihiko Higuti :
Sirt2の発現抑制安定株の作成とミトコンドリアに与える影響の解析,
日本薬学会第130年会, Mar. 2010.
2. 西田 華, 喜多 俊行, Naokatu Arakaki, Hirofumi Shibata and Tomihiko Higuti :
ポリフェノール類の脂肪細胞に対する効果とその機構の解析,
日本薬学会第130年会, Mar. 2010.
3. 引地 香織, Hirofumi Shibata and Tomihiko Higuti :
銀翹散のin vitro抗インフルエンザウイルス活性について,
第57回日本化学療法学会総会, Jun. 2009.
4. 三木 あかね, 菊石 美也子, Harumi Hinode, Mami Azuma, Tomihiko Higuti, Koichiro Tsuchiya, Masaru Kihara and Yoshihisa Takaishi :
徳島大学薬学部における自学能力育成への取組,
日本薬学会129年会, 0, Mar. 2009.
5. 伏谷 秀治, Hirofumi Shibata, 柴田 高洋, Kazuyoshi Kawazoe, 安倍 正博, Shinji Abe, Tomihiko Higuti, 庄野 文章 and Kazuo Minakuchi :
徳島大学病院病棟における環境中の浮遊真菌調査について,
第24回日本環境感染学会総会, Feb. 2009.
6. 河野 渉, 引地 香織, Hirofumi Shibata, Shinji Abe, Kazuyoshi Kawazoe, Kazuo Minakuchi and Tomihiko Higuti :
銀翹散のin vitro抗インフルエンザウイルス活性につて,
第47回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, 97, Nov. 2008.
7. 河野 渉, 引地 香織, Hirofumi Shibata, Shinji Abe, 川添 和義, 水口 和生 and Tomihiko Higuti :
銀翹散のin vitro抗インフルエンザウイルス活性について,
第47回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Nov. 2008.
8. 引地 香織, Hirofumi Shibata and Tomihiko Higuti :
銀翹散のin vitro抗インフルエンザウイルス活性について,
第57回日本感染症学会東日本地方学術集会第55回日本化学療法学会東日本支部総会合同学会, Oct. 2008.
9. 立石 樹理, Hirofumi Shibata and Tomihiko Higuti :
緑膿菌排出ポンプに対するアルキルガレートの作用,
第61回日本細菌学会中国四国支部総会, Oct. 2008.
10. Takanori Kamakura, Yoshiki Kashiwada, Hirofumi Shibata, Tomihiko Higuti and Yoshihisa Takaishi :
キク科カレープラントHelichrysum itallicum subsp. serotinumの抗MRSA活性成分の探索研究,
日本生薬学会第55回(2008)年会, 279, Sep. 2008.
11. 柴田 高洋, Hirofumi Shibata, 伏谷 秀治, Kazuyoshi Kawazoe, 阿倍 正博, Tomihiko Higuti, Kazuo Minakuchi and 庄野 文章 :
徳島大学病院病棟内における浮遊菌調査,
第18回日本医療薬学会年会, 246, Sep. 2008.
12. 石塚 洋, Hirofumi Shibata and Tomihiko Higuti :
緑膿菌の侵襲性を指標とした新規抗菌活性物質のスクリーニング,
第56回日本化学療法学会総会, Jun. 2008.
13. 西谷 典子, 石塚 洋, Hirofumi Shibata, 川添 和義, Tomihiko Higuti and 水口 和生 :
MDCK cellmonolayerpenetrationassayによる漢方製剤の緑膿菌侵襲性に及ぼす影響,
日本薬学会第128年会, Mar. 2008.
14. 橋本 敏弘, 浅川 義範, 中野 達郎, Hirofumi Shibata, 新垣 尚捷 and Tomihiko Higuti :
苔類より単離されるビスビベンジル化合物の抗耐性菌活性,
日本薬学会第128年会, Mar. 2008.
15. 青井 博志, Hirofumi Shibata and Tomihiko Higuti :
短鎖アルキルガレートによるオクチルガレートの -ラクタム剤感受性増強効果の発現増強作用,
第81回日本細菌学会総会, Mar. 2008.
16. MAK Parvez, Hirofumi Shibata and Tomihiko Higuti :
No relationship exists between PBP 2a amounts expressed in MRSA and -lactams MIC-values,
第81回日本細菌学会総会, Mar. 2008.
17. 河添 仁, 高岡 恭子, 阿部 真博, Hirofumi Shibata, 新垣 尚捷, Tomihiko Higuti, 芳地 一, 土屋 浩一郎 and 滝口 祥令 :
ニューキノロン系抗菌薬と金属カチオンの相互作用を利用した腸内殺菌療法,
第28回日本臨床薬理学会年会, Nov. 2007.
18. 青井 博志, 森吉 雅代, Hirofumi Shibata and Tomihiko Higuti :
アルキルガレートによる黄色ブドウ球菌エンテロトキシンの分泌阻害,
第46回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Nov. 2007.
19. 石塚 洋, 西谷 典子, Hirofumi Shibata, 新見 伸吾, 川添 和義, 水口 和生 and Tomihiko Higuti :
緑膿菌の侵襲性を指標とした新規抗菌活性物質探索スクリーニングシステムの構築,
第46回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Nov. 2007.
20. 西村 和也, 鎌倉 孝法, Yoshiki Kashiwada, Yoshihisa Takaishi, Hirofumi Shibata and Tomihiko Higuti :
白コショウ(Piper nigrum)の成分研究, --- - ---,
第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会要旨集, Nov. 2007.
21. Hirofumi Shibata and Tomihiko Higuti :
アルキルガレートによるメチシリン耐性黄色ブドウ球菌のβ‐ラクタム剤感受性増強メカニズムの解析,
第55回日本化学療法学会西日本支部総会, Oct. 2007.
22. 中野 達朗, Hirofumi Shibata and Tomihiko Higuti :
MRSAに対するオクチルガレートのβ-ラクタム剤感受性増強効果の短鎖アルキルガレートによる増強作用,
第60回日本細菌学会中国四国支部総会, Oct. 2007.
23. 中野 達朗, Hirofumi Shibata, 岡坂 衛, 村上 光太郎, 高石 喜久 and Tomihiko Higuti :
MRSAをはじめとする薬剤耐性菌に対する生薬由来の抗菌活性成分の探索,
第52回ブドウ球菌研究会, Sep. 2007.
24. MAK Anowar Khasru Parvez Md., Hirofumi Shibata, T Nakano, N Eguchi, H Aoi, Y Itoh and Tomihiko Higuti :
Action mechanism of ILSMRs in MRSA,
第52回ブドウ球菌研究会, Sep. 2007.
25. Yoshiki Kashiwada, Yoshihisa Takaishi, Hirofumi Shibata, Tomihiko Higuti and 黒川 昌彦 :
エラグ酸誘導体の抗MRSA活性及び抗HSV活性, --- - ---,
第52回日本ブドウ球菌研究会要旨集, Sep. 2007.
26. Yoshiki Kashiwada, Hirofumi Shibata, Tomihiko Higuti and Yoshihisa Takaishi :
エラグ酸誘導体の抗菌活性について,
日本生薬学会第54年会, Sep. 2007.
27. Hirofumi Shibata and Tomihiko Higuti :
アルキルガレートによる黄色ブドウ球菌エンテロトキシンの分泌阻害,
第55回日本化学療法学会総会, Jun. 2007.
28. 鎌倉 孝法, 越智 俊政, Yoshiki Kashiwada, Yoshihisa Takaishi, Hirofumi Shibata and Tomihiko Higuti :
メースMyristica fragrans)の成分研究,
日本薬学会第127年会, Mar. 2007.
29. 中野 達朗, Hirofumi Shibata and Tomihiko Higuti :
MRSAのβ-ラクタム剤に対する耐性のオクチルガレートと金属イオンによるモジュレーション,
第80回日本細菌学会総会, Mar. 2007.
30. Kazuyoshi Kawazoe, Hirofumi Shibata, Tomihiko Higuti and Yoshihisa Takaishi :
植物に新しい抗MRSA薬を求めて,
日本化学会西日本大会, 265, Nov. 2006.
31. Mami Azuma, Masaru Kihara, Tomihiko Higuti, Yoshihisa Takaishi and Takashi Yamauchi :
徳島大学における早期体験学習導入とその評価,
第16回 日本医療薬学会年会, Sep. 2006.
32. Hirofumi Shibata, 近藤 京子, Kazuyoshi Kawazoe, Yoshihisa Takaishi, Yoshimitsu Nagao and Tomihiko Higuti :
MRSAに対するオクチルガレートの抗菌・抗アイルスマー活性に及ぼす金属イオンの影響,
第51回日本ブドウ球菌研究会, Sep. 2006.
33. 鎌倉 孝法, 越智 俊政, Yoshihisa Takaishi, Hirofumi Shibata and Tomihiko Higuti :
メース(Myristica fragrans)の成分研究,
日本薬学会第126年会, Mar. 2006.
34. 江口 奈穂子, Hirofumi Shibata, 近藤 京子, 荒井 勉, 塔本 香奈, 友石 章夫, Kazuyoshi Kawazoe, Yoshihisa Takaishi, 堀内 義史, 樋口 雅紀 and Tomihiko Higuti :
アイルスマー(MRSAに対するβ-ラクタム剤感受性増強薬)の創製,
第44回日本薬学会・日本病院薬剤師会中国四国支部学術大会, 84, Nov. 2005.

Patent:

1. Tomihiko Higuti, Hirofumi Shibata, Youichi Sato, Yoshihisa Takaishi, Kazuyoshi Kawazoe and Kotaro Murakami : Medical composition for treating infection with drugresistant Staphylococcus aureus, PIXXD2 WO 2004066992 A1 20040812 CAN 141:167738 AN 2004:648378 CAPLUS (Apr. 2004).
2. Kazuyoshi Kawazoe, Yoshihisa Takaishi, Tomihiko Higuti and Hirofumi Shibata : Anti-MRSA agents, 2001-400259 (Dec. 2001), 3979843 (Jul. 2007).

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Second survey on the folk medicine of minority groups in Yunnan Province of China, and a study about its utilization (Project/Area Number: 18406028 )
  • Molecular analysis of anteliotic-tolerance and stress response in adherent bacteria (Project/Area Number: 17591914 )
  • JVSマウスを用いたミトコンドリアのバイオジェネシスに係わる新規蛋白質因子の解析 (Project/Area Number: 15657029 )
  • Mechanism of encephalitis after influenza virus infection based on defect of β-oxidation in liver (Project/Area Number: 15590942 )
  • JVSマウスを用いたミトコンドリアのバイオジェネシスに係わる新規蛋白質因子の解析 (Project/Area Number: 14658207 )
  • TITLE OF PROJECT : Invention of intensifiers of antibiotics-susceptibility against multi-drugs resistant pathogenic bacteria and invesrigation for novel control system of multi-drugs resistance (Project/Area Number: 14390038 )
  • ミトコンドリア増生の分子シンクロナイゼイションと新規蛋白質因子の解析 (Project/Area Number: 13022248 )
  • 血管新生をターゲットにした癌悪性化阻止戦略―血管内皮細胞膜に存在するH^+-ATP合成酵素阻害剤のスクリーニングと癌治療への応用― (Project/Area Number: 13216077 )
  • Novel factors in the biogenesis of mitochondrial reticulum found from heart of juvenile visceral steatosis mouse (Project/Area Number: 12480191 )
  • Development of "induces of β-lactam-susceptibility in MRSA (ILSMR)" and elucidaton of the novel regulatory mechanism (Project/Area Number: 11558085 )
  • ATP合成酵素の分子構築における遺伝子制御の分子シンクロナイゼイション機構 (Project/Area Number: 11167259 )
  • Studies on new antimicrobial agents from crude drugs against nosocomial methicillin-resistant Staphylococcus aureus (Project/Area Number: 07558095 )
  • 生体分子素構造の人工的組織構造化による新機能発現 (Project/Area Number: 07241103 )
  • Mitochondrial H^+-ATP synthase as a Paralled Condenser (Project/Area Number: 07044274 )
  • Transcriptional regulation proteins of human ATP synthae subunit b gene (Project/Area Number: 06454656 )
  • ヒトH^+-ATP合成酵素subunit b遺伝子の発現制御に係る蛋白質因子の解析 (Project/Area Number: 05680555 )
  • ミトコンドリアATP合成酵素-分子構築,エネルギー変換とCa制御の分子機作の解明 (Project/Area Number: 05259219 )
  • ヒトH±ATP合成酵素のsubunitb遺伝子の発現制御機作 (Project/Area Number: 04680196 )
  • ミトコンドリアH^+-ATP合成酵素の分子構築とエネルギー変換機作 (Project/Area Number: 04266215 )
  • 抗がん剤の効果増強の新システムの開発 (Project/Area Number: 04253230 )
  • 生体情報・エネルギー変換分子材料の設計および機能制御 (Project/Area Number: 04204007 )
  • 生体情報・エネルギ-変換分子材料の設計および機能制御 (Project/Area Number: 03204009 )
  • 生体情報・エネルギ-変換分子材料の設計および機能制御 (Project/Area Number: 02204009 )
  • Developmental research of selective toxic anticancer drug and cancer-diagnose drug targeting cancer mitochondria (Project/Area Number: 01880022 )
  • チャージリンーその三次構造の解明とエネルギー変換機作の研究 (Project/Area Number: 63617508 )
  • CHARGERIN---ITS TERTIARY STRUCTURE AND THE MECHANISM OF ENERGY TRANSDUCTION (Project/Area Number: 63480502 )
  • チャージリンーその分子構造とエネルギー変換機作の研究 (Project/Area Number: 62580124 )
  • Chargerins which generate Negative Charges on the Outer Surface of Mitochondrial Inner Membrane (Project/Area Number: 60480502 )
  • Search by Researcher Number (50035557)