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Research Activity

Field of Study

Lipid Biochemistry

Subject of Study

Study on physiologicaqlly active phospholipids, Pathophysiological role of oxidized phospholipids (lysophospholipid, lysophosphatidic acid, atherosclerosis, platelet-activating factor, oxidized lipid) (Physiological roles of lysophospholipid mediators such as lysophosphatidic acid, lysophosphatidylcholine and sphingosine-1-phosphate have been examined. Characterizations of lysolipid-producing or degrading enzymes that controls their local levels in the body has been challenged, and clarification of their functional roles have been attempted. In response to increased oxidative stress, phospholipids in biomembranes are subjected peroxidation reaction, generating secondary phospholipids having an oxidatively shorten fatty acyl group that resembles platelet-activating factor (PAF, inflammatory mediator) in structure. Both mechanism of the PAF-like oxidized phospholipids and their diverse biological activities have been examined. Also, their possible involvement in the pathogenesis of vascular diseases including atherosclerosis has been evaluated.)

Book / Paper

Book:

1. Akira Tokumura :
6. 活性リン脂質,6.3 コリン含有リン脂質とその代謝物,
朝倉書店, Tokyo, Nov. 2010.
2. Akira Tokumura :
6.活性リン脂質 6.1 初めに(概要と歴史),
朝倉書店, Tokyo, Nov. 2010.
3. Kenji Fukuzawa, Kentaro Kogure, 真鍋 幸恵 and Akira Tokumura :
ビタミンE研究の進歩 XII,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, 2007.
4. Kenji Fukuzawa, 木崎 真弓, 真鍋 幸恵 and Akira Tokumura :
ビタミンE研究の進歩 XII,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, 2007.
5. Akira Tokumura :
環境衛生学辞典,
MARUZEN Co.,Ltd., 2005.
6. 真鍋 幸恵, Kentaro Kogure, 森田 健之, Akira Tokumura and Kenji Fukuzawa :
ビタミンE研究の進歩 XI,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, 2004.
7. Kenji Fukuzawa, Kentaro Kogure, 中島 佐和, 土江 明子 and Akira Tokumura :
ビタミンE研究の進歩 XI,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, 2004.
8. Kentaro Kogure, Akira Tokumura and Kenji Fukuzawa :
ビタミンE研究の進歩 X,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, 2002.
9. 濱 進, Kentaro Kogure, 森田 元喜, Akira Tokumura and Kenji Fukuzawa :
ビタミンE研究の進歩 X,
KYORITSU SHUPPAN.CO.,LTD, Tokyo, 2002.
10. Akira Tokumura :
基礎生化学実験法 5巻 脂質・糖質・複合糖質,
Tokyo Kagaku Dozin C., Ltd., 2000.
11. Akira Tokumura :
生物薬科学実験講座 1巻 生体構成成分と高分子1–3 脂質,
株式会社 廣川書店, Tokyo, 1998.
12. Akira Tokumura :
生物薬科学実験講座 1巻 生体構成成分と高分子1–3 脂質,
株式会社 廣川書店, Tokyo, 1998.
13. Tamotsu Tanaka, Kiyoshi Satouchi and Akira Tokumura :
高度不飽和脂肪酸ーAA,EPA,DHAー 分布,分離,代謝,機能と利用,
恒星社厚生閣, Tokyo, 1995.
14. Akira Tokumura and 塚谷 博昭 :
総説プロスタグランジン 2,
現代医療社, 1994.
15. Akira Tokumura and 塚谷 博昭 :
食品の生態調節機能,
Japan Scientific Societies Press, Tokyo, 1992.
16. Akira Tokumura :
続 医薬品の開発 5巻 生理活性物質の分離と精製,
株式会社 廣川書店, Tokyo, 1991.
17. Akira Tokumura :
膜酵素ー基礎と実験ー,
株式会社 廣川書店, Tokyo, 1990.
18. Akira Tokumura and 塚谷 博昭 :
現代化学増刊 17 血小板活性化因子-生合成,生理,病理-,
Tokyo Kagaku Dozin C., Ltd., 1988.
19. Akira Tokumura and 塚谷 博昭 :
現代化学増刊 17 血小板活性化因子-生合成,生理,病理-,
Tokyo Kagaku Dozin C., Ltd., 1988.
20. Akira Tokumura :
講座プロスタグランジン8巻 PGをめぐる新物質,
Tokyo Kagaku Dozin C., Ltd., Tokyo, 1988.
21. J Donald Hanahan, Hiroshi Homma, J Sugatani, Akira Tokumura and E D. Ayer :
Biochemical characteristics of the interaction of synthetic platelet-activating factor with platelets,
1986.
22. Akira Tokumura :
生物化学実験法 17巻生体膜成分の構造と機能,
Japan Scientific Societies Press, Tokyo, 1982.
23. Akira Tokumura :
生物化学実験法 17巻生体膜成分の構造と機能,
Japan Scientific Societies Press, Tokyo, 1982.
24. Akira Tokumura :
生物化学実験法 17巻生体膜成分の構造と機能,
Japan Scientific Societies Press, Tokyo, 1982.

Academic Paper (Judged Full Paper):

1. Sheuli Afroz, Ayano Yagi, Kouki Fujikawa, M. Motiur Rahman, Katsuya Morito, Tatsuya Fukuta, Shiro Watanabe, Kazunori Toida, Emi Kiyokage, Taro Shimizu, Tatsuhiro Ishida, Kentaro Kogure, Akira Tokumura and Tamotsu Tanaka :
Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro,
Prostaglandins & Other Lipid Mediators, Vol.135, 36-44, 2018.
(Tokushima University Institutional Repository: 112025,   DOI: 10.1016/j.prostaglandins.2018.01.003,   PubMed: 29462674,   Elsevier: Scopus)
2. Manami Inoue, Kazuhito Tsuboi, Yoko Okamoto, Mayumi Hidaka, Toru Uyama, Toshihiko Tsutsumi, Tamotsu Tanaka, Natsuo Ueda and Akira Tokumura :
Peripheral tissue levels and molecular species compositions of N-acyl-phosphatidylethanolamine and its metabolites in mice lacking N-acyl-phosphatidylethanolamine-specific phospholipase D.,
The Journal of Biochemistry, Vol.162, No.6, 449-458, 2017.
(DOI: 10.1093/jb/mvx054,   PubMed: 28992041,   Elsevier: Scopus)
3. Kida Takashi, Itoh Aoi, Kimura Akari, Matsuoka Hisatsugu, Imai Hiroyuki, Kentaro Kogure, Akira Tokumura and Tamotsu Tanaka :
Distribution of glycosylinositol phosphoceramide-specific phospholipase D activity in plants,
The Journal of Biochemistry, Vol.161, No.2, 187-195, 2017.
(DOI: 10.1093/jb/mvw060,   PubMed: 28175321,   CiNii: 40021133480,   Elsevier: Scopus)
4. S Afroz, Teru Ikoma, Ayano Yagi, Kentaro Kogure, Akira Tokumura and Tamotsu Tanaka :
Concentrated phosphatidic acid in cereal brans as potential protective agents against indomethacin-induced stomach ulcer.,
Journal of Agricultural and Food Chemistry, Vol.64, No.37, 6950-6957, 2016.
(DOI: 10.1021/acs.jafc.6b02884,   PubMed: 27561232)
5. Iffat Sonia Ara Rahman, Kazuhito Tsuboi, Zahir Hussain, Ryouhei Yamashita, Yoko Okamoto, Toru Uyama, Naoshi Yamazaki, Tamotsu Tanaka, Akira Tokumura and Natsuo Ueda :
Calcium-dependent generation of N-acylethanolamines and lysophosphatidic acids by glycerophosphodiesterase GDE7.,
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1861, No.12 pt A, 1881-1892, 2016.
(DOI: 10.1016/j.bbalip.2016.09.008,   PubMed: 27637550,   Elsevier: Scopus)
6. Junpei Yamamoto, Midori Omura, Koichiro Tuchiya, Mayumi Hidaka, Akira Kuwahara, Minoru Irahara, Tamotsu Tanaka and Akira Tokumura :
Preferable existence of polyunsaturated lysophosphatidic acids in human follicular fluid from patients programmed with in vitro fertilization.,
Prostaglandins & Other Lipid Mediators, Vol.126, 16-23, 2016.
(DOI: 10.1016/j.prostaglandins.2016.07.008,   PubMed: 27421691,   Elsevier: Scopus)
7. Toshihiko Tsutsumi, Yoko Okamoto, Syougo Yamakawa, Cheng Bingjun, Akira Ishihara, Tamotsu Tanaka and Akira Tokumura :
Reduced rat plasma lysophosphatidylglycerol or lysophosphatidic acid level as a biomarker of aristolochic acid-induced renal and adipose dysfunctions.,
Life Sciences, Vol.157, 208-216, 2016.
(DOI: 10.1016/j.lfs.2016.06.003,   PubMed: 27267499,   Elsevier: Scopus)
8. 喜田 孝史, 木村 朱里, 伊藤 葵, 山下 量平, Kentaro Kogure, Akira Tokumura and Tamotsu Tanaka :
食品に含まれるグリコシルイノシトールホスホセラミドおよびフィトセラミド-1-リン酸,
脂質栄養学, Vol.25, 75-85, 2016.
9. Ryouhei Yamashita, Yumika Tabata, Erina Iga, Michiyasu Nakao, Shigeki Sano, Kentaro Kogure, Akira Tokumura and Tamotsu Tanaka :
Analysis of molecular species profiles of ceramide-1-phosphate and sphingomyelin using MALDI-TOF mass spectrometry,
Lipids, Vol.51, No.2, 263-270, 2016.
(DOI: 10.1007/s11745-015-4082-0,   PubMed: 26694604,   Elsevier: Scopus)
10. Toshihiko Tsutsumi, Syougo Yamakawa, Akira Ishihara, Aimi Yamamoto, Tamotsu Tanaka and Akira Tokumura :
Reduced kidney levels of lysophosphatidic acids in rats after chronic administration of aristolochic acid: Its possible protective role in renal fibrosis,
Toxicology Reports, Vol.2, 121-129, 2015.
(DOI: 10.1016/j.toxrep.2015.02.012,   Elsevier: Scopus)
11. Yoshibumi Shimizu, Yoshiyuki Morikawa, Shinichi Okudaira, Shigenobu Kimoto, Tamotsu Tanaka, Junken Aoki and Akira Tokumura :
Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin.,
The American Journal of Pathology, Vol.184, No.5, 1593-1603, 2014.
(DOI: 10.1016/j.ajpath.2014.01.029,   PubMed: 24641902,   Elsevier: Scopus)
12. Tamotsu Tanaka, Sachika Uozumi, Katsuya Morito, Takashi Osumi and Akira Tokumura :
Metabolic conversion of C20 polymethylene-interrupted polyunsaturated fatty acids to essential fatty acids.,
Lipids, Vol.49, No.5, 423-429, 2014.
(DOI: 10.1007/s11745-014-3896-5,   PubMed: 24659112,   Elsevier: Scopus)
13. Tamotsu Tanaka, Mayumi Ohmoto, Katsuya Morito, H. Kondo, Mai Urikura, Kiyoshi Satouchi and Akira Tokumura :
Type 2 lysophosphatidic acid receptor in gastric surface mucous cells: Possible implication of prostaglandin E2 production,
BioFactors, Vol.40, No.3, 355-361, 2014.
(DOI: 10.1002/biof.1147,   PubMed: 24375908,   Elsevier: Scopus)
14. Yoshibumi Shimizu, Kazutoshi Murao, Tamotsu Tanaka, Yoshiaki Kubo and Akira Tokumura :
Increased lysophospholipase D activity of autotaxin in sera of patients with atopic dermatitis.,
Journal of Dermatological Science, Vol.74, No.2, 162-165, 2014.
(DOI: 10.1016/j.jdermsci.2014.01.010,   PubMed: 24582488,   Elsevier: Scopus)
15. Tamotsu Tanaka, T. Kida, H. Imai, J. Morishige, R. Yamashita, H. Matsuoka, S. Uozumi, K. Satouchi, M. Nagano and Akira Tokumura :
Identification of a sphingolipid-specific phospholipase D activity associated with the generation of phytoceramide-1-phosphate in cabbage leaves,
The FEBS Journal, Vol.280, No.16, 3797-3809, 2013.
(DOI: 10.1111/febs.12374,   PubMed: 23738625)
16. Mari Kotosai, Sachiko Shimada, Mai Kanda, Namiko Matsuda, Keiko Sekido, Yoshibumi Shimizu, Akira Tokumura, Toshiyuki Nakamura, Kaeko Murota, Yoshichika Kawai and Junji Terao :
Plasma HDL reduces nonesterified fatty acid hydroperoxides originating from oxidized LDL.,
Lipids, Vol.48, No.6, 569-578, 2013.
(DOI: 10.1007/s11745-013-3779-1,   PubMed: 23494578,   Elsevier: Scopus)
17. Junichi Morishige, Yoshihiro Uto, Hitoshi Hori, Kiyoshi Satouchi, Tanihiro Yoshiomoto and Akira Tokumura :
Lysophosphatidic Acid Produced by Hen Egg White Lysophospholipase D Induces Vascular Development on Extraembryonic Membranes,
Lipids, Vol.48, No.3, 251-262, 2013.
(DOI: 10.1007/s11745-013-3765-7,   PubMed: 23381130,   Elsevier: Scopus)
18. Tamotsu Tanaka, Morito K., Kinoshita M., Ohmoto M., Urikura M., Satouchi K. and Akira Tokumura :
Orally administered phosphatidic acids and lysophosphatidic acids ameliorate aspirin-induced stomach mucosal injury in mice,
Digestive Diseases and Sciences, Vol.58, No.4, 950-958, 2013.
(DOI: 10.1007/s10620-012-2475-y,   PubMed: 23161268)
19. Tohru Uyama, Natsuki Ikematsu, Manami Inoue, Naoki Shinohara, X-H Jin, Kazuhito Tsuboi, Tekuharu Tonai, Akira Tokumura and Natsuo Ueda :
Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family,
The Journal of Biological Chemistry, Vol.287, No.38, 31905-31919, 2012.
(DOI: 10.1074/jbc.M112.368712,   PubMed: 22825852,   Elsevier: Scopus)
20. Tamotsu Tanaka, Ayaka Kassai, Mayumi Ohmoto, Katsuya Morito, Yoshiki Kashiwada, Yoshihisa Takaishi, Mai Urikura, Jun-ichi Morishige, Kiyoshi Satouchi and Akira Tokumura :
Quantification of phosphatidic acid in foodstuffs using TLC-imaging technique,
Journal of Agricultural and Food Chemistry, Vol.60, No.16, 4156-4161, 2012.
(DOI: 10.1021/jf300147y,   PubMed: 22475031,   Elsevier: Scopus)
21. Akira Tokumura, Satoshi Taira, Masaki Kikuchi, Toshihiko Tsutsumi, Yoshibumi Shimizu and Michell A Watsky :
Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury.,
Prostaglandins & Other Lipid Mediators, Vol.97, No.3-4, 83-89, 2012.
(DOI: 10.1016/j.prostaglandins.2012.01.003,   PubMed: 22281604,   Elsevier: Scopus)
22. Tamotsu Tanaka, 盛重 純一, 瓜倉 真衣, Akira Tokumura and 里内 清 :
Mass spectrometric analysis of phospholipids with phosphate monoester residue using Phos-tag,
SEIBUTSU BUTSURI KAGAKU, Vol.56, s37-42, 2012.
(CiNii: 40019214190)
23. Masaki Ino, Yoshibumi Shimizu, Tamotsu Tanaka and Akira Tokumura :
Alterations of plasma levels of lysophosphatidic acid in response to fasting of rats,
Biological & Pharmaceutical Bulletin, Vol.35, No.11, 2059-2063, 2012.
(DOI: 10.1248/bpb.b12-00497,   PubMed: 23123475)
24. Kazuhito Tsuboi, Yasuo Okamoto, Natsuki Ikematsu, Manami Inoue, Yoshinobu Shimizu, Toru Uyama, Jun Wang, G Dale Deutsch, P Mattew Burns, M Nadine Ulloa, Akira Tokumura and Natsuo Ueda :
Enzymatic formation of N-acylethanolamine from N-acylethanlamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways.,
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1811, No.10, 568-577, 2011.
(DOI: 10.1016/j.bbalip.2011.07.009,   PubMed: 21801852,   Elsevier: Scopus)
25. Manami Inoue, Mika Adachi, Yoshibumi Shimizu, Toshihiko Tsutsumi and Akira Tokumura :
Compariosns of lysophospholipid levles in rat feces with those in a standard chow,
Journal of Agricultural and Food Chemistry, Vol.59, No.13, 7062-7067, 2011.
(DOI: 10.1021/jf200986k,   PubMed: 21648420,   Elsevier: Scopus)
26. Saki Yoshino, Aya Hara, Hiroyuki Sakakibara, Kyuichi Kawabata, Akira Tokumura, Akari Ishisaka, Yoshichika Kawai and Junji Terao :
Effect of quercetin and glucuronide metabolites on the monoamine oxidase-A reaction in mouse brain mitochondria.,
Nutrition, 2011.
(DOI: 10.1016/j.nut.2010.09.002,   PubMed: 21371861)
27. Akira Tokumura :
Physiological significance of lysophosphatidic acids that act on the lumen side of mammalian lower digestive tracts,
Journal of Health Science, Vol.57, No.2, 115-128, 2011.
(DOI: 10.1248/jhs.57.115,   CiNii: 130000663110)
28. Kaori Ueda, Masanori Yoshihara, Michiyasu Nakao, Tamotsu Tanaka, Shigeki Sano, Kenji Fukuzawa and Akira Tokumura :
Evaluation of inhibitory actions of flavonols and related substances on lysophospholipase d activity of serum autotaxin by a convenient assay using a chromogenic substrate.,
Journal of Agricultural and Food Chemistry, Vol.58, No.10, 6053-6063, 2010.
(DOI: 10.1021/jf904155a,   PubMed: 20415488)
29. Saori Oka, Shunsuke Arai, Keizo Waku, Akira Tokumura and Takayuki Sugiura :
Depolarization-induced rapid generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in rat brain synaptosomes,
The Journal of Biochemistry, Vol.141, No.5, 687-697, 2007.
(DOI: 10.1093/jb/mvm070,   PubMed: 17339228,   Elsevier: Scopus)
30. Akira Tokumura, Tetsuya Kume, Kenji Fukuzawa, Masahiro Tahara, Keiichi Tasaka, Junken Aoki, Hiroyuki Arai, Katsuhiko Yasuda and Hideyo Kanzaki :
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity,
Life Sciences, Vol.80, No.18, 1641-1649, 2007.
(DOI: 10.1016/j.lfs.2006.12.041,   PubMed: 17367815,   Elsevier: Scopus)
31. Junichi Morishige, Kanako Touchika, Tamotsu Tanaka, Kiyoshi Satouchi, Kenji Fukuzawa and Akira Tokumura :
Production of bioactive lysophosphatidic acid by lysophospholipase D in hen egg white,
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1771, No.4, 491-499, 2007.
(DOI: 10.1016/j.bbalip.2007.01.005,   PubMed: 17321793)
32. Toshihiko Tsutsumi, Junichi Morishige, Kenji Fukuzawa and Akira Tokumura :
Movememt of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcinr kidney epithelial cell line LLC-PK1,
Prostaglandins & Other Lipid Mediators, Vol.83, No.1-2, 33-41, 2007.
(DOI: 10.1016/j.prostaglandins.2006.09.007,   PubMed: 17259070,   Elsevier: Scopus)
33. Kenji Fukuzawa, Aya Fujisaki, Kaori Akai, Akira Tokumura, Junji Terao and Jansuz M. Gebicki :
Measurement of phosphatidylcholine hydroperoxides in solution and in intact membranes by the ferric-xylenol orange assay,
Analytical Biochemistry: Methods in the Biological Sciences, Vol.359, No.1, 18-25, 2006.
(DOI: 10.1016/j.ab.2006.09.011,   PubMed: 17049475,   Elsevier: Scopus)
34. Junko Komatsu, Shuji Yamano, Akira Kuwahara, Akira Tokumura and Minoru Irahara :
The signalling pathways linking to lysophosphatidic acid-promoted meiotic maturation,
Life Sciences, Vol.79, No.5, 506-511, 2006.
(DOI: 10.1016/j.lfs.2006.01.028,   PubMed: 16492384)
35. Kentaro Kogure, Sachie Manabe, Ichiro Suzuki, Akira Tokumura and Kenji Fukuzawa :
Cytotoxicity of α-tocopheryl succinate, malonate and oxalate in normal and cancer cells in vitro and their anti-cancer effects on mouse melanoma in vivo,
Journal of Nutritional Science and Vitaminology, Vol.51, No.6, 392-397, 2005.
(DOI: 10.3177/jnsv.51.392,   PubMed: 16521697,   Elsevier: Scopus)
36. Yuko Fujiwara, Vineet Sardar, Akira Tokumura, Daniel Baker, Kimiko Murakami-Murofushi, Abby Parrill and Gabor Tigyi :
Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells.,
The Journal of Biological Chemistry, Vol.280, No.41, 35038-35050, 2005.
(DOI: 10.1074/jbc.M504351200,   PubMed: 16115890,   Elsevier: Scopus)
37. Koichiro Tsuchiya, Kaori Akai, Akira Tokumura, Shinji Abe, Toshiaki Tamaki, Yoshiharu Takiguchi and Kenji Fukuzawa :
Oxygen radical photo-induced by ferric nitrilotriacetate complex,
Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1725, No.1, 111-119, 2005.
(DOI: 10.1016/j.bbagen.2005.05.001,   PubMed: 15950386)
38. 三木 新也, 吉永 至宏務, 安田 恒雄, Akira Tokumura and Kenji Fukuzawa :
慢性絞扼障害モデルにおける新規神経因性疼痛治療薬OT-7100の効果,
薬理と治療, Vol.33, No.7, 705-711, 2005.
39. Kenji Fukuzawa, Yasuaki Saitoh, Kaori Akai, Kentaro Kogure, Satoru Ueno, Akira Tokumura, Masaki Otagiri and Akira Shibata :
Antioxidant effect of bovine serum albumin on membrane lipid peroxidation induced by iron chelate and superoxide,
Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1668, No.1, 145-155, 2005.
(DOI: 10.1016/j.bbamem.2004.12.006,   PubMed: 15670740)
40. Kentaro Kogure, Aiko Yamauchi, Akira Tokumura, Kyoko Kondou, Naonobu Tanaka, Yoshihisa Takaishi and Kenji Fukuzawa :
Novel antioxidants isolated from plants of the genera Ferula, Inula, Prangos and Rheum collected in Uzbekistan,
Phytomedicine, Vol.11, No.7-8, 645-651, 2004.
(DOI: 10.1016/j.phymed.2003.09.004,   PubMed: 15636179)
41. Tamotsu Tanaka, Hideki Tsutsui, Kaoru Hirano, Tohru Koike, Akira Tokumura and Kiyoshi Satouchi :
Quantitative analysis of lysophosphatidic acid by time-of-flight mass spectrometry using a phosphate-capture molecule,
Journal of Lipid Research, Vol.45, No.11, 2145-2150, 2004.
(DOI: 10.1194/jlr.D400010-JLR200,   PubMed: 15314093,   Elsevier: Scopus)
42. Koji Nakagawa, Shuji Yamano, Masaharu Kamada, Masahiko Maegawa, Akira Tokumura, Minoru Irahara and Hidekazu Saito :
Sperm-immobilizing antibodies suppress an increase in the plasma membrane fluidity of human spermatozoa,
Fertility and Sterility, Vol.82, No.Supplement 3, 1054-1058, 2004.
(DOI: 10.1016/j.fertnstert.2004.03.034,   PubMed: 15474073)
43. Kaori Akai, Koichiro Tsuchiya, Akira Tokumura, Kentaro Kogure, Satoru Ueno, Akira Shibata, Toshiaki Tamaki and Kenji Fukuzawa :
Ability of ferric nitrilotriacetate complex with three pH-dependent conformations to induce lipid peroxidation.,
Free Radical Research, Vol.38, No.9, 951-962, 2004.
(DOI: 10.1080/1071576042000261945,   PubMed: 15621713)
44. Kentaro Kogure, Susumu Hama, Mayumi Kisaki, Hideaki Takemasa, Akira Tokumura, Ichiro Suzuki and Kenji Fukuzawa :
Structural characteristic of terminal dicarboxyric moiety required for apoptogenic activity of α-Tocopheryl esters.,
Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1672, No.2, 93-99, 2004.
(DOI: 10.1016/j.bbagen.2004.03.001,   PubMed: 15110091,   Elsevier: Scopus)
45. Shuji Yamano, Jun Yamazaki, Minoru Irahara, Akira Tokumura, Koji Nakagawa and Hidekazu Saito :
Human spermatozoa capacitated with progesterone or a long incubation show accelerated internalization by an alkyl ether lysophospholipid,
Fertility and Sterility, Vol.81, No.3, 605-610, 2004.
(DOI: 10.1016/j.fertnstert.2003.07.036,   PubMed: 15037409)
46. Toshihiko Tsutsumi, Akira Tokumura, Masaya Yamaguchi, Shikifumi Kitazawa and Yusuke Tanigawara :
Phorbol Myristate Acetate Stimulates Degradation of a Structural Analogue of Platelet-Activating Factor to a Neutral Lipid in Human Leukemic K562 Cells: Relevance to the Release of Lipids,
Biological & Pharmaceutical Bulletin, Vol.27, No.1, 24-28, 2004.
(DOI: 10.1248/bpb.27.24,   PubMed: 14709893,   Elsevier: Scopus)
47. Kentaro Kogure, Sawa Nakashima, Akiko Tsuchie, Akira Tokumura and Kenji Fukuzawa :
Temporary membrane distortion of vascular smooth muscle cells is responsible for their apoptosis induced by platelet-activating factor-like oxidized phospholipids and thair degradation product lysophosphatidylcholine.,
Chemistry and Physics of Lipids, Vol.126, No.1, 29-38, 2003.
(DOI: 10.1016/S0009-3084(03)00091-4,   PubMed: 14580708,   Elsevier: Scopus)
48. Kentaro Kogure, Susumu Hama, Satoru GOTO, Tatsuo Munakata, Akira Tokumura and Kenji Fukuzawa :
alpha-Tocopheryl succinate activates protein kinase C in cellular and cell-free systems,
Journal of Nutritional Science and Vitaminology, Vol.49, No.5, 310-314, 2003.
(DOI: 10.3177/jnsv.49.310,   PubMed: 14703304,   CiNii: 10012074064,   Elsevier: Scopus)
49. Saori Oka, Akiko Tsuchie, Akira Tokumura, Mayumi Muramatsu, Yoshitomo Suhara, Hiroaki Takayama, Keizo Waku and Takayuki Sugiura :
Ether-linked analog of 2-arachidonoylglycerol (noladin ether) was not detected in the brains of various mammalian species,
Journal of Neurochemistry, Vol.85, No.6, 1374-1381, 2003.
(DOI: 10.1046/j.1471-4159.2003.01804.x,   PubMed: 12787057,   Elsevier: Scopus)
50. Kentaro Kogure, Sachie Manabe, Susumu Hama, Akira Tokumura and Kenji Fukuzawa :
Potentiation of anti-cancer effect by intravenous administration of vesiculated α-tocopheryl hemisuccinate on mouse melanoma in vivo.,
Cancer Letters, Vol.192, No.1, 19-24, 2003.
(DOI: 10.1016/S0304-3835(02)00683-3,   PubMed: 12637149,   Elsevier: Scopus)
51. Kentaro Kogure, Susumu Hama, Sachie Manabe, Akira Tokumura and Kenji Fukuzawa :
High cytotoxicity of α-tocopheryl hemisuccinate to cancer cells is due to failure of their antioxidative defense systems.,
Cancer Letters, Vol.186, No.2, 151-156, 2002.
(DOI: 10.1016/S0304-3835(02)00344-0,   PubMed: 12213284,   Elsevier: Scopus)
52. Akira Tokumura, Yumi Kanaya, Maki Miyake, Shuji Yamano, Minoru Irahara and Kenji Fukuzawa :
Increased Production of Bioactive Lysophosphatidic Acid by Serum Lysophospholipase D in Human Pregnancy,
Biology of Reproduction, Vol.67, No.5, 1386-1392, 2002.
(DOI: 10.1095/biolreprod.102.004051,   PubMed: 12390867,   Elsevier: Scopus)
53. Akira Tokumura, Eiji Majima, Yuko Kariya, Kyoko Tominaga, Kentarou Kogure, KAtuhiko Yasuda and Kenji Fukuzawa :
Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase,
The Journal of Biological Chemistry, Vol.277, No.42, 39436-39442, 2002.
(DOI: 10.1074/jbc.M205623200,   PubMed: 12176993,   Elsevier: Scopus)
54. Takayuki Sugiura, Shinji Nakane, Seishi Kishimoto, keizo Waku, Yasuko Yoshioka and Akira Tokumura :
Lysophosphatidic acid, a growth factor-like lipid, in the saliva,
Journal of Lipid Research, Vol.43, No.12, 2049-2055, 2002.
(DOI: 10.1194/jlr.M200242-JLR200,   PubMed: 12454265,   Elsevier: Scopus)
55. Akira Tokumura, Junya Shinomiya, Seishi Kishimoto, Tamotsu Tanaka, Kentaro Kogure, Takayuki Sugiura, Kiyoshi Satouchi, Keizo Waku and Kenji Fukuzawa :
Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids,
The Biochemical Journal, Vol.365, No.Pt 3, 617-628, 2002.
(DOI: 10.1042/BJ20020348,   PubMed: 11982483,   CiNii: 80015451613,   Elsevier: Scopus)
56. Shinji Nakane, Saori Oka, Shunsuke Arai, Keizo Waku, Yoshio Ishima, Akira Tokumura and Takayuki Sugiura :
2-Arachidonoyl-sn-glycero-3-phosphate, an arachidonic acid-containing lysophosphatidic acid: occurrence and rapid enzymatic conversion to 2-arachidonoyl-sn-glycerol, a cannabinoid receptor ligand, in rat brain,
Archives of Biochemistry and Biophysics, Vol.402, No.1, 51-58, 2002.
(DOI: 10.1016/S0003-9861(02)00038-3,   PubMed: 12051682,   CiNii: 80015298377,   Elsevier: Scopus)
57. Kentaro Kogure, Motoki Morita, Susumu Hama, Sawa Nakashima, Akira Tokumura and Kenji Fukuzawa :
Enhancement by α-tocopheryl hemisuccinate of nitric oxide production induced by lypopolysaccharide and interferon-γ through up-regulation of protein kinase C in rat vascular smooth muscle cells.,
European Journal of Biochemistry, Vol.269, No.9, 2367-2372, 2002.
(DOI: 10.1046/j.1432-1033.2002.02894.x,   PubMed: 11985620,   CiNii: 80015568784,   Elsevier: Scopus)
58. Yumi Kanaya, Akira Tokumura, Masaki Kitahara, Maki Miyake, Yasuko Yoshioka and Kenji Fukuzawa :
Increased formation of lysophosphatidic acids by lysophospholipase D in serum of hypercholesterolemic rabbits.,
Journal of Lipid Research, Vol.43, No.2, 307-315, 2002.
(PubMed: 11861673,   Elsevier: Scopus)
59. Kenji Hinokio, Shuji Yamano, Koji Nakagawa, Minoru Irahara, Masaharu Kamada, Akira Tokumura and Toshihiro Aono :
Lysophosphatidic acid stimulates nuclear and cytoplasmic maturation of golden hamster immature oocytes in vitro via cumulus cells,
Life Sciences, Vol.70, No.7, 759-767, 2002.
(PubMed: 11833739)
60. Akira Tokumura, Kyoko Tominaga, Yasuda Katsuhiko, Hideharu Kanzaki, Kentaro Kogure and Kenji Fukuzawa :
Lack of significant differences in the corrected activity of lysophospholipase D, producer of phospholipid mediator lysophosphatidic acid, in incubated serum from women with and without ovarian tumors,
Cancer, Vol.94, No.1, 141-151, 2002.
(DOI: 10.1002/cncr.10146,   PubMed: 11815970,   Elsevier: Scopus)
61. Kentaro Kogure, Motoki Morita, Sawa Nakashima, Susumu Hama, Akira Tokumura and Kenji Fukuzawa :
Superoxide is responsible for apoptosis in rat vascular smooth muscle cells induced by α-tocopheryl hemisuccinate.,
Biochimica et Biophysica Acta (BBA) - General Subjects, Vol.1528, No.1, 25-30, 2001.
(DOI: 10.1016/S0304-4165(01)00168-4,   PubMed: 11514094)
62. Kazuaki Yokoyama, Shigeaki Saitoh, Mayuko Ishida, Yoshio Yamakawa, Kazumi Nakamura, Keizo Inoue, Ryo Taguchi, Akira Tokumura, Masahiro Nishijima, Mitsuhiro Yanagida and Morio Setaka :
Very-long-chain fatty acid-containing phospholipids accumulate in fatty acid synthase temperature-sensitive mutant strains of the fission yeast Schizosaccharomyces pombe fas2/lsd1,
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1532, No.3, 223-233, 2001.
(DOI: 10.1016/S1388-1981(01)00134-2,   PubMed: 11470243,   Elsevier: Scopus)
63. Shinji Nakane, Keizo Waku, Akira Tokumura and Takayuki Sugiura :
Hen egg yolk and white contain high amounts of lysophosphatidic acids, growth factor-like lipids: distinct molecular species compositions,
Lipids, Vol.36, No.4, 413-419, 2001.
(PubMed: 11383695,   Elsevier: Scopus)
64. Kenji Fukuzawa, Akira Tokumura, Kentaro Kogure, Masahito Iemura, Naoto Gondoh, Masanobu Fujii, Satoru Ueno and Akira Shibata :
A comparative study of the ability of ferric nitrilotriacetate and other iron chelators to assist membrane lipid peroxidation by superoxide radicals,
Chemistry and Physics of Lipids, Vol.110, No.1, 69-84, 2001.
(PubMed: 11245836)
65. Akira Tokumura, T. Sumida, M. Toujima, Kentaro Kogure, Kenji Fukuzawa, Y. Takahashi and S. Yamamoto :
Structural identification of phosphatidylcholines having an oxidatively shortened linoleate residue generated through its oxygenation with soybean or rabbit reticulocyte lipoxygenase.,
Journal of Lipid Research, Vol.41, No.6, 953-962, 2000.
(PubMed: 10828088,   Elsevier: Scopus)
66. Takayuki Sugiura, Shinji Nakane, Seishi Kishimoto, Keizo Waku, Yasuko Yoshioka, Akira Tokumura and Donald J Hanahan :
Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells,
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1440, No.2-3, 194-204, 1999.
(DOI: 10.1016/S1388-1981(99)00127-4,   PubMed: 10521703,   Elsevier: Scopus)
67. kenji Kunikata, Shuji Yamano, Akira Tokumura and Toshihiro Aono :
Effect of lysophosphatidic acid on the ovum transport in mouse oviducts,
Life Sciences, Vol.65, No.8, 833-840, 1999.
(DOI: 10.1016/S0024-3205(99)00310-0,   PubMed: 10466749,   Elsevier: Scopus)
68. Akira Tokumura, Maki Miyake, Yuko Nishioka, Shuji Yamano, Toshihiro Aono and Kenji Fukuzawa :
Production of Lysophosphatidic Acids by Lysophospholipase D in Human Follicular Fluids of In Vitro Fertilization Patients,
Biology of Reproduction, Vol.61, No.1, 195-199, 1999.
(DOI: 10.1095/biolreprod61.1.195,   PubMed: 10377049,   Elsevier: Scopus)
69. Akira Tokumura, Hiroaki Fujimoto, Osamu Yoshimoto, Yuko Nishioka, Maki Miyake and Kenji Fukuzawa :
Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats,
Life Sciences, Vol.65, No.3, 245-253, 1999.
(DOI: 10.1016/S0024-3205(99)00243-X,   PubMed: 10447209,   Elsevier: Scopus)
70. Takayo Sasagawa, Tatsuzo Oka, Akira Tokumura, Yuriko Nishimoto, Saturnino Munoz, Masashi Kuwahata, Misako Okita, Hideaki Tsuji and Yasuo Natori :
Analysis of the fatty acid components in a perchloric acid-soluble protein,
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1437, No.3, 317-324, 1999.
(DOI: 10.1016/S1388-1981(99)00025-6,   PubMed: 10101265,   Elsevier: Scopus)
71. Akira Tokumura, Yuko Nishioka, Osamu Yoshimoto, Junya Shinomiya and Kenji Fukuzawa :
Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma,
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1437, No.2, 235-245, 1999.
(DOI: 10.1016/S1388-1981(99)00011-6,   PubMed: 10064906,   Elsevier: Scopus)
72. Akira Tokumura, Maki Miyake, Osamu Yoshimoto, Mayumi Shimizu and Kenji Fukuzawa :
Metal-ion stimulation and inhibition of lysophospholipase D which generates bioactive lysophosphatidic acid in rat plasma,
Lipids, Vol.33, No.10, 1009-1015, 1998.
(DOI: 10.1007/s11745-998-0299-2,   PubMed: 9832081)
73. Kenji Fukuzawa, Yasuki Inokami, Akira Tokumura, Junji Terao and Asahi Suzuki :
Rate constants for quenching singlet oxygen and activities for inhibiting lipid peroxidation of carotenoids and alpha-tocopherol in liposomes,
Lipids, Vol.33, No.8, 751-756, 1998.
(PubMed: 9727604,   Elsevier: Scopus)
74. Sachiko Kondo, Takayuki Sugiura, Tomoko Kodaka, Naomi Kudo, Keizo Waku and Akira Tokumura :
Accumulation of VariousN-Acylethanolamines IncludingN-Arachidonoylethanolamine (Anandamide) in Cadmium Chloride-Administered Rat Testis,
Archives of Biochemistry and Biophysics, Vol.354, No.2, 303-310, 1998.
(DOI: 10.1006/abbi.1998.0688,   PubMed: 9637740,   Elsevier: Scopus)
75. Sachiko Kondo, Hironori Kondo, Shinji Nakane, Tomoko Kodaka, Akira Tokumura, Keizo Waku and Takayuki Sugiura :
2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist: identification as one of the major species of monoacylglycerols in various rat tissues, and evidence for its generation through Ca2+-dependent and -independent mechanisms,
FEBS Letters, Vol.429, No.2, 152-156, 1998.
76. Toshihiko Tsutsumi, Akira Tokumura and Shikifumi Kitazawa :
Undifferentiated HL-60 cells internalize an antitumor alkyl ether phospholipid more rapidly than resistant K562 cells,
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1390, No.1, 73-84, 1998.
(DOI: 10.1016/S0005-2760(97)00171-9,   PubMed: 9487142,   Elsevier: Scopus)
77. Akira Tokumura, Masaaki Okuno, Kenji Fukuzawa, Hitoshi Houchi, Koichiro Tsuchiya and Motoo Oka :
Positive and negative controls by protein kinases of sodium-dependent Ca2+ efflux from cultured bovine adrenal chromaffin cells stimulated by lysophosphatidic acid,
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1389, No.1, 67-75, 1998.
(DOI: 10.1016/S0005-2760(97)00130-6,   PubMed: 9443605)
78. Kenji Fukuzawa, Yasuki Inokami, Akira Tokumura, Junji Terao and Asahi Suzuki :
Singlet oxygen scavenging by lpha-tocopherol and eta-carotene: Kinetic studies in phospholipid membranes and ethanol solution,
BioFactors, Vol.7, No.1-2, 31-40, 1998.
(DOI: 10.1002/biof.5520070106,   PubMed: 9523026)
79. Akira Tokumura, Toshihiko Tsutsumi, Yuko Nishioka and Hiroaki Tsukatani :
Exogenously added alkylmethylglycerophosphocholine and alkylmethylcarbamylglycerophosphocholine accumulate in plasma membranes more than in intracellular membranes of rabbit platelets,
Chemistry and Physics of Lipids, Vol.86, No.1, 75-83, 1997.
(DOI: 10.1016/S0009-3084(97)02664-9,   PubMed: 9149390,   Elsevier: Scopus)
80. Akira Tokumura, Tomoko Moriyama, Hiroshi Minamino, Takao Hayakawa and Hiroaki Tsukatani :
Exogenous phosphatidic acid with saturated short-chain fatty acyl groups induces superoxide anion release from guinea pig peritoneal polymorphonuclear leukocytes by three different mechanisms,
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1344, No.1, 87-102, 1997.
(DOI: 10.1016/S0005-2760(96)00130-0,   PubMed: 9022758,   Elsevier: Scopus)
81. Kenji Fukuzawa, Kayo Matsuura, Akira Tokumura, Asahi Suzuki and Junji Terao :
Kinetics and Dynamics of Singlet Oxygen Scavenging by -Tocopherol in Phospholipid Model Membranes,
Free Radical Biology and Medicine, Vol.22, No.5, 923-930, 1997.
(DOI: 10.1016/S0891-5849(96)00485-6,   PubMed: 9119263,   Elsevier: Scopus)
82. Akira Tokumura, M Toujima, Yasuko Yoshioka and Kenji Fukuzawa :
Lipid peroxidation in low density lipoproteins from human plasma and egg yolk promotes accumulation of 1-acyl analogues of platelet-activating factor-like lipids,
Lipids, Vol.31, No.12, 1251-1258, 1996.
(DOI: 10.1007/BF02587909,   PubMed: 8972457,   Elsevier: Scopus)
83. Akira Tokumura, Masaaki Okuno, Kenji Fukuzawa, Hitoshi Houchi and Motoo Oka :
Two effects of lysophosphatidic acid on Ca(2+)-movement in cultured bovine adrenal chromaffin cells,
Journal of Lipid Mediators and Cell Signalling, Vol.14, No.1-3, 127-135, 1996.
(DOI: 10.1016/0929-7855(96)00518-4,   PubMed: 8906555,   Elsevier: Scopus)
84. Kenji Fukuzawa, Masahito Iemura and Akira Tokumura :
Lipid peroxidation in egg phosphatidylcholine liposomes: comparative studies on the induction systems Fe2+/ascorbate and Fe3+-chelates/xanthine-xanthine oxidase.,
Biological & Pharmaceutical Bulletin, Vol.19, No.5, 665-671, 1996.
(PubMed: 8741572,   CiNii: 110003641238,   Elsevier: Scopus)
85. Hitoshi Houchi, M. Okuno, Masayuki Shono, Akira Tokumura and M. Oka :
Regulations by cyclic nucleotides and phorbol ester of calcium efflux from cultured bovine adrenal chromaffin cells.,
Life Sciences, Vol.57, No.15, 211-215, 1995.
86. Akira Tokumura, T Yotsumoto, Y Masuda and S Tanaka :
Vasopressor effect of lysophosphatidic acid on spontaneously hypertensive rats and Wistar Kyoto rats,
Research Communications in Molecular Pathology and Pharmacology, Vol.90, No.1, 96-102, 1995.
(PubMed: 8581353,   Elsevier: Scopus)
87. Takayuki Sugiura, Atsushi Yamashita, Naomi Kudo, Teruo Fukuda, Tatsuya Miyamoto, Neng Neng Cheng, Seishi Kishimoto, Keizo Waku, Tamotsu Tanaka, Hiroaki Tsukatani and Akira Tokumura :
Platelet-activating factor and its structural analogues in the earthworm Eisenia foetida,
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1258, No.1, 19-26, 1995.
(DOI: 10.1016/0005-2760(95)00090-Y,   PubMed: 7654776,   Elsevier: Scopus)
88. Tamotsu Tanaka, Akira Tokumura and H. Tsukatani :
Platelet activating factor (PAF)-like phospholipids formed during peroxidation of phosphatidylcholines from different foodstuffs,
Bioscience, Biotechnology, and Biochemistry, Vol.59, No.8, 1389-1393, 1995.
(DOI: 10.1271/bbb.59.1389,   PubMed: 7549088)
89. Kazushi Minami, Yasushi Hirata, Akira Tokumura, Yutaka Nakaya and Kenji Fukuzawa :
Protein kinase c-independent inhibition of the Ca2+-activated K+ channel by angiotensin II and endothelin-1,
Biochemical Pharmacology, Vol.49, No.8, 1051-1056, 1995.
(DOI: 10.1016/0006-2952(95)98500-9,   PubMed: 7748184,   Elsevier: Scopus)
90. Kenji Fukuzawa, Keiji Soumi, Masahito Iemura, Satoru GOTO and Akira Tokumura :
Dynamics of xanthine oxidase- and Fe^{3+}-ADP-dependent lipid peroxidation in negatively charged phospholipid vesicles,
Archives of Biochemistry and Biophysics, Vol.316, No.1, 83-91, 1995.
(DOI: 10.1006/abbi.1995.1013,   PubMed: 7840682,   Elsevier: Scopus)
91. T. Sugiura, A. Yamashita, N. Kudo, Tamotsu Tanaka and Akira Tokumura :
Platelet-activating factor and its structural analogues in the earthworm Eisenia foetida,
Biochim. Biophys. Acta, Vol.1258, 19-26, 1995.
92. Hitoshi Houchi, Masaaki Okuno, Akira Tokumura, M Yoshizumi, Kenji Fukuzawa and Motoo Oka :
Stimulatory effect of lysophosphatidic acid on calcium efflux from cultured bovine adrenal chromaffin cells,
Life Sciences, Vol.57, 205-210, 1995.
93. Hitoshi Houchi, Masaaki Okuno, M Shono, Akira Tokumura and Motoo Oka :
Regulation by cyclic nucleotides and phorbol ester of calcium efflux from cultured bovine Adrenal chromaffin ccells,
Life Sciences, Vol.57, 211-215, 1995.
94. Hitoshi Houchi, Masaaki Okuno, Katsuji Kitamura, Yasuko Ishimura, Takeshi Ohuchi, Akira Tokumura and Motoo Oka :
Stimulatory effect of angiotensin II on calcium efflux from cultured bovine adrenal chromaffin cells,
Life Sciences, Vol.56, No.5, 109-114, 1994.
(DOI: 10.1016/0024-3205(94)00962-7,   PubMed: 7837925,   Elsevier: Scopus)
95. Tsuzuki Kobayashi, Shuji Yamano, Shinji Murayama, Hiromi Ishikawa, Akira Tokumura and Toshihiro Aono :
Effect of lysophosphatidic acid on the preimplantation development of mouse embryos,
FEBS Letters, Vol.351, No.1, 38-40, 1994.
(DOI: 10.1016/0014-5793(94)00815-9,   PubMed: 8076690,   Elsevier: Scopus)
96. Akira Tokumura, Makoto Iimori, Yuko Nishioka, Maki Kitahara, Mitsuaki Sakashita and Sakuya Tanaka :
Lysophosphatidic acids induce proliferation of cultured vascular smooth muscle cells from rat aorta,
The American Journal of Physiology, Vol.267, No.1 Pt 1, 204-210, 1994.
(PubMed: 8048480,   Elsevier: Scopus)
97. Takayuki Sugiura, Akira Tokumura, L Gregory, Teri Nouchi, T S. Weintraub and J Donald Hanahan :
Biochemical Characterization of the Interaction of Lipid Phosphoric Acids with Human Platelets: Comparison with Platelet Activating Factor,
Archives of Biochemistry and Biophysics, Vol.311, No.2, 358-368, 1994.
(DOI: 10.1006/abbi.1994.1249,   PubMed: 8203898,   Elsevier: Scopus)
98. Tamotsu Tanaka, M Iimori, Hiroaki Tsukatani and Akira Tokumura :
Platelet-aggregating effects of platelet-activating factor-like phospholipids formed by oxidation of phosphatidylcholines containing an sn-2-polyunsaturated fatty acyl group,
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1210, No.2, 202-208, 1994.
(DOI: 10.1016/0005-2760(94)90122-8,   PubMed: 8280771,   Elsevier: Scopus)
99. Tamotsu Tanaka, H. Iimori, H. Tsukatani and Akira Tokumura :
Platelet-aggregating effects of platelet-activating factor-like phospholipids formed by oxidation of phosphatidylcholines containing an sn-2 polyunsaturated fatty acyl group,
Biochim. Biophys. Acta, Vol.1210, 202-208, 1994.
100. Tamotsu Tanaka, H. Minamino, S. Unezaki, H. Tsukatani and Akira Tokumura :
Formation of platelet-activating factor-like phospholipids by Fe2+/ascorbate/EDTA-induced lipid peroxidation,
Biochim. Biophys. Acta, Vol.1210, 202-208, 1994.
101. Marilena E Lekka, Akira Tokumura, Hideaki Tsuji and Donald J Hanahan :
Isolation of a phospholipid inhibitor of platelet activating factor-induced activity from perfused rat liver: identification as phosphatidylglycerol,
Archives of Biochemistry and Biophysics, Vol.302, No.2, 380-384, 1993.
(DOI: 10.1006/abbi.1993.1227,   PubMed: 8489242,   Elsevier: Scopus)
102. Tamotsu Tanaka, Hiroshi Minamino, S Unezaki, Hiroaki Tsukatani and Akira Tokumura :
Formation of platelet-activating factor-like phospholipids by Fe2+/ascorbate/EDTA-induced lipid peroxidation,
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1166, No.2-3, 264-274, 1993.
(DOI: 10.1016/0005-2760(93)90107-K,   PubMed: 8443246,   Elsevier: Scopus)
103. Yasuhito Nakagawa, Masaki Sugai, Ken Karasawa, Akira Tokumura, Hiroaki Tsukatani, Morio Setaka and Shoshichi Nojima :
Possible influence of lysophospholipase on the production of 1-acyl-2-acetylglycerophosphocholine in macrophages,
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.1126, No.3, 277-285, 1992.
(DOI: 10.1016/0005-2760(92)90241-M,   PubMed: 1637856,   Elsevier: Scopus)
104. Akira Tokumura, Toshihiko Tsutsumi and Hiroaki Tsukatani :
Transbilayer movement and metabolic fate of ether-linked phosphatidic acid (1-O-Octadecyl-2-acetyl-sn-glycerol 3-phosphate) in guinea pig peritoneal polymorphonuclear leukocytes,
The Journal of Biological Chemistry, Vol.267, No.11, 7275-7283, 1992.
105. Akira Tokumura, Takashi Yotsumoto, T. Hoshikawa, Tamotsu Tanaka and Hiroaki Tsukatani :
Quantitative analysis of platelet-activating factor in rat brain,
Life Sciences, Vol.51, 303-308, 1992.
106. Masanobu Fujii, Akira Tokumura, Toshihiko Tsutsumi, Hiroaki Tsukatani, Mikiko Kano and Akira Tanaka :
Residue analysis of oleic acid in cucumber fruits after spraying sodium oleate solution,
Journal of Pesticide Science, Vol.17, No.3, 141-145, 1992.
(DOI: 10.1584/jpestics.17.3_141,   CiNii: 130004263055)
107. Akira Tokumura, Takashi Yotsumoto, Takefumi Hoshikawa, Tamotsu Tanaka and Hiroaki Tsukatani :
Quantitative analysis of platelet-activating factor in rat brain,
Life Sciences, Vol.51, No.4, 303-308, 1992.
(DOI: 10.1016/0024-3205(92)90089-8,   PubMed: 1625522,   Elsevier: Scopus)
108. Akira Tokumura, Nobuyuki Yube, Motonori Terao and Hiroaki Tsukatani :
Antagonism of platelet-activating factor in isolated rat colon: possible mechanism,
Lipids, Vol.26, No.12, 1344-1346, 1991.
(DOI: 10.1007/BF02536563,   PubMed: 1819730,   Elsevier: Scopus)
109. Akira Tokumura, Nobuyuki Yube, Hiroaki Fujimoto and Hiroaki Tsukatani :
Lysophosphatidic acids induce contraction of rat isolated colon by two different mechanisms,
The Journal of Pharmacy and Pharmacology, Vol.43, No.11, 774-778, 1991.
(DOI: 10.1111/j.2042-7158.1991.tb03480.x,   PubMed: 1686905,   Elsevier: Scopus)
110. Akira Tokumura, Tamotsu Tanaka, Takashi Yotsumoto and Hiroaki Tsukatani :
Identification of sn-2-ω-hydroxycarboxylate-containing phospholipids in a lipid extract from bovine brain,
Biochemical and Biophysical Research Communications, Vol.177, No.1, 466-473, 1991.
(DOI: 10.1016/0006-291X(91)92007-7,   PubMed: 2043133,   Elsevier: Scopus)
111. Akira Tokumura, Toshihiko Tsutsumi, Junichi Yoshida and Hiroaki Tsukatani :
Translocation of exogenous platelet-activating factor and its lyso-compound through plasma membranes is a rate-limiting step for their metabolic conversions into alkylacylglycerophosphocholines in rabbit platelets and guinea-pig leukocytes,
Biochimica et Biophysica Acta (BBA) - Bioenergetics, Vol.1044, No.1, 91-100, 1990.
(DOI: 10.1016/0005-2760(90)90223-K,   PubMed: 2340312,   Elsevier: Scopus)
112. Akira Tokumura, Kazuya Morisawa, Akihiko Hiroshima, Toshihiko Tsutsumi, Kenji Fukuzawa and Hiroaki Tsukatani :
Calcium movements in rabbit platelets induced by platelet-activating factor and its regulation by an antagonist of platelet-activating factor,,
platelet-activating factor and its regulation by an antagonist of platelet-activating factor,, Vol.9, 63-71, 1990.
113. Kenji Fukuzawa, Y Kurotori, Akira Tokumura and Hiroaki Tsukatani :
Vitamin E. deficiency increases the synthesis of platelet-activating factor (PAF) in rat polymorphonuclear leucocytes,
Lipids, Vol.24, No.3, 236-239, 1989.
(DOI: 10.1007/BF02535242,   PubMed: 2761359,   Elsevier: Scopus)
114. Akira Tokumura, Kenkichi Takauchi, Tsuyoshi Asai, Koumei Kamiyasu, Tadashi Ogawa and Hiroaki Tsukatani :
Novel molecular analogues of phosphatidylcholines in a lipid extract from bovine brain: 1-long-chain acyl-2-short-chain acyl-sn-glycero-3- phosphocholines,
Journal of Lipid Research, Vol.30, No.2, 219-224, 1989.
115. Akira Tokumura, Tsuyoshi Asai, Keichnki Takauchi, Koumei Kamiyasu, Tadashi Ogawa and Hiroaki Tsukatani :
Novel phospholipids with aliphatic dicarboxylic acid residues in a lipid extract from bovine brain,
Biochemical and Biophysical Research Communications, Vol.155, No.2, 863-869, 1988.
(DOI: 10.1016/S0006-291X(88)80575-8,   PubMed: 3421972,   Elsevier: Scopus)
116. Akira Tokumura, M Terao, M Okamoto, K Yoshida and Hiroaki Tsukatani :
Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis,
European Journal of Pharmacology, Vol.148, No.3, 353-360, 1988.
(PubMed: 3384001,   Elsevier: Scopus)
117. Kenji Fukuzawa, Katsuya Kishikawa, Toyohiro Tadokoro, Akira Tokumura, Hiroaki Tsukatani and Janusz M Gebicki :
The effect of a-tocopherol on site-specific lipid peroxidation induced by iron in charged micelles,
Archives of Biochemistry and Biophysics, Vol.260, No.1, 153-160, 1988.
(DOI: 10.1016/0003-9861(88)90436-5,   PubMed: 3341738,   Elsevier: Scopus)
118. Hiroshi Homma, Akira Tokumura and J Donald Hanahan :
Binding and internalization of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in washed rabbit platelets,
The Journal of Biological Chemistry, Vol.262, No.22, 10582-10587, 1987.
(PubMed: 3038889,   Elsevier: Scopus)
119. Akira Tokumura, Koumei Kamiyasu, Kenkichi Takauchi and Hiroaki Tsukatani :
Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain,
Biochemical and Biophysical Research Communications, Vol.145, No.1, 415-425, 1987.
(DOI: 10.1016/0006-291X(87)91338-6,   PubMed: 3593346,   Elsevier: Scopus)
120. Akira Tokumura, Junichi Yoshida, Takayuki Maruyama, Kenji Fukuzawa and Hiroaki Tsukatani :
Platelet aggregation induced by ether-linked phospholipids. 1. Inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor,
Thrombosis Research, Vol.46, No.1, 51-63, 1987.
(DOI: 10.1016/0049-3848(87)90206-4,   PubMed: 3647677,   Elsevier: Scopus)
121. Akira Tokumura, Junichi Yoshida, Nobuko Okasaka, Kenji Fukuzawa and Hiroaki Tsukatani :
Platelet aggregation induced by ether-linked phospholipids. 2. Mechanism of desensitization of rabbit platelets by platelet activating factor and reversibility of inhibitory actions of its antagonists,
Thrombosis Research, Vol.46, No.1, 153-161, 1987.
(DOI: 10.1016/0049-3848(87)90215-5,   PubMed: 3590110,   Elsevier: Scopus)
122. Junichi Yoshida, Akira Tokumura, Kenji Fukuzawa, Motomori Terao, Kenkichi Takauchi and Hiroaki Tsukatani :
A platelet-aggregating and hypotensive phospholipid isolated from bovine brain,
The Journal of Pharmacy and Pharmacology, Vol.38, No.12, 878-882, 1986.
(DOI: 10.1111/j.2042-7158.1986.tb03375.x,   PubMed: 2880959)
123. Akira Tokumura, William Kramp and Donald J Hanahan :
Alkylacetylglycerophosphocholine effects on the metabolism of phospholipids in rabbit platelets: effects of extracellular Ca2+ and prostacyclin,
Archives of Biochemistry and Biophysics, Vol.247, No.2, 403-413, 1986.
(DOI: 10.1016/0003-9861(86)90599-0,   PubMed: 3013094,   Elsevier: Scopus)
124. Akira Tokumura, Yasuko Yoshioka, Hiroaki Tsukatani and Yasomi Handa :
Gas chromatographic/mass spectrometric analyses of ether-linked lysophosphatidic acid and its analogues,
Biomedical & Environmental Mass Spectrometry, Vol.13, No.4, 175-180, 1986.
(DOI: 10.1002/bms.1200130405)
125. Akira Tokumura, Kengo Harada, Kenji Fukuzawa and Hiroaki Tsukatani :
Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma.,
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Vol.875, No.1, 31-38, 1986.
(DOI: 10.1016/0005-2760(86)90007-X,   PubMed: 3632787,   Elsevier: Scopus)
126. Kenji Fukuzawa, K Kishikawa, Akira Tokumura, Hiroaki Tsukatani and M Shibuya :
Fluorescent pigments by covalent binding of lipid peroxidation by-products to protein and amino acids,
Lipids, Vol.20, No.12, 854-861, 1985.
(DOI: 10.1007/BF02534768,   PubMed: 4094516,   Elsevier: Scopus)
127. J Donald Hanahan, T Susan Weintraub, J Samuel Friedberg, Akira Tokumura and E D. Ayer :
A novel approach to structure proof of glyceryl ether-containing glycerophospholipids. Base-catalyzed methanolysis of platelet-activating factor (AGEPC) at 60 degrees C,
Journal of Lipid Research, Vol.26, No.11, 1345-1355, 1985.
(PubMed: 4067422,   Elsevier: Scopus)
128. Akira Tokumura, Hiroshi Homma and J Donald Hanahan :
Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation,
The Journal of Biological Chemistry, Vol.260, No.23, 12710-12714, 1985.
(PubMed: 3840169,   Elsevier: Scopus)
129. Akira Tokumura, T Suzuki, Kenkichi Takauchi and Hiroaki Tsukatani :
Gas chromatographic-mass spectrometric analysis of biologically active phospholipids having an sn-2-acetyl group.,
Journal of Chromatography, Vol.343, No.1, 138-142, 1985.
(DOI: 10.1016/S0378-4347(00)84576-4,   PubMed: 4066848,   Elsevier: Scopus)
130. Kenkichi Takauchi, Akira Tokumura, Junichi Yoshida, T Iwama, Yasomi Handa, H Tatsumichi and Hiroaki Tsukatani :
Identification of steroidal compounds as acetates in a lysate of "Depressor-I," an antihypertensive phospholipid occurring in acetone-soluble fraction of bovine brain,
Chemical & Pharmaceutical Bulletin, Vol.33, No.4, 1334-1341, 1985.
(DOI: 10.1248/cpb.33.1334,   PubMed: 4042217,   CiNii: 130003770158)
131. Hiroaki Tsukatani, Kenkichi Takauchi, Junichi Yoshida, Sadaji Yamada, Akira Tokumura and C Hamaguchi :
Isolation of diosgenin[(25R)-spirost-5-en-3 beta-ol] from a lysate of a new hypotensive phospholipid occurring in bovine brain,
Journal of Neurochemistry, Vol.44, No.2, 658-661, 1985.
(PubMed: 3965623,   Elsevier: Scopus)
132. Akira Tokumura, H M. Mostafa, R D. Nelson and J Donald Hanahan :
Stimulation of (Ca2++Mg2+)-ATPase in human erythrocytes membranes by synthetic lysophosphatidic acids and lysophosphatidylcholines. Effects of chain length and degree of unsaturation,
Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.812, No.2, 568-574, 1985.
(DOI: 10.1016/0005-2736(85)90332-3,   PubMed: 3155625,   Elsevier: Scopus)
133. Akira Tokumura, T Maruyama, Kenji Fukuzawa and Hiroaki Tsukatani :
Effects of lysophosphatidic acids and their structural analogs on arterial blood pressure of cats,
Arzneimittel-Forschung, Vol.35, No.3, 287-292, 1985.
(PubMed: 3846454,   Elsevier: Scopus)
134. Hiroaki Tsukatani, Junichi Yoshida, Kenkichi Takauchi, Sadaji Yamada, Akira Tokumura, K Nakanishi and T Hayakawa :
Comparison of antispasmodic effect of synthetic lysolecithins with various fatty acid moieties on guinea pig ileum,
Journal of Pharmacobio-Dynamics, Vol.7, No.6, 400-406, 1984.
(PubMed: 6481614,   Elsevier: Scopus)
135. Akira Tokumura, K Harada, Yasuko Yoshioka, Hiroaki Tsukatani and Yasomi Handa :
Analyses of lysophosphatidic acids by gas chromatography mass spectrometry without hydrolytic pretreatment,
Biomedical Mass Spectrometry, Vol.11, No.4, 167-171, 1984.
(DOI: 10.1002/bms.1200110406,   PubMed: 6563919)
136. Akira Tokumura, Kenji Fukuzawa and Hiroaki Tsukatani :
Contractile action of 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine on strips of isolated rat intestine,
The Journal of Pharmacy and Pharmacology, Vol.36, No.3, 210-212, 1984.
(PubMed: 6144763)
137. Akira Tokumura, Yasomi Handa, Yasuko Yoshioka and Hiroaki Tsukatani :
Mass spectrometric analyses of biologically active choline phospholipids and their lysoderivatives,
Chemical & Pharmaceutical Bulletin, Vol.31, No.12, 4425-4435, 1983.
(CiNii: 110003624209)
138. Akira Tokumura, K Harada, Kenji Fukuzawa and Hiroaki Tsukatani :
Biphasic action of platelet-activating factor on isolated guinea-pig ileum,
Lipids, Vol.18, No.11, 848-850, 1983.
(DOI: 10.1007/BF02534647,   PubMed: 6656539,   Elsevier: Scopus)
139. Akira Tokumura, Kenji Fukuzawa and Hiroaki Tsukatani :
Contractile actions of lysophosphatidic acids with a chemically-defined fatty acyl group on longitudinal muscle from guinea-pig ileum.,
The Journal of Pharmacy and Pharmacology, Vol.34, No.8, 514-516, 1982.
(PubMed: 6126563,   Elsevier: Scopus)
140. Kenji Fukuzawa, Akira Tokumura, S Ouchi and Hiroaki Tsukatani :
Antioxidant activities of tocopherols on Fe2+-ascorbate-induced lipid peroxidation in lecithin liposomes,
Lipids, Vol.17, No.7, 511-513, 1982.
(DOI: 10.1007/BF02535334,   PubMed: 7121213,   Elsevier: Scopus)
141. Akira Tokumura, Yasomi Handa, Yasuko Yoshioka, Minoru Higashimoto and Hiroaki Tsukatani :
Mass Spectrometric analyses of lysophosphatidic acids and their dimethyl ester,
Chemical & Pharmaceutical Bulletin, Vol.30, 2119-2126, 1982.
142. Akira Tokumura, Tetsuya Kume, Kenji Fukuzawa and Hiroaki Tsukatani :
Cardiovascular effects of lysophosphatidic acid and its structural analogs in rats,
The Journal of Pharmacology and Experimental Therapeutics, Vol.219, No.1, 219-224, 1981.
(PubMed: 6116795,   Elsevier: Scopus)
143. Akira Tokumura, Kenji Fukuzawa, Junichi Isobe and Hiroaki Tsukatani :
Lysophosphatidic acid-induced aggregation of human and feline platelets: Structure-activity relationship,
Biochemical and Biophysical Research Communications, Vol.99, No.2, 391-398, 1981.
(DOI: 10.1016/0006-291X(81)91758-7,   PubMed: 6909028,   Elsevier: Scopus)
144. Kenji Fukuzawa, Hisako Chiba, Akira Tokumura and Hiroaki Tsukatani :
Antioxidative. effect of a-tocopherol incorporation into. lecithin liposomes on ascorbic acid-. Fe2+-induced lipid peroxidation,
Archives of Biochemistry and Biophysics, Vol.206, No.1, 173-180, 1981.
(DOI: 10.1016/0003-9861(81)90078-3,   PubMed: 7212715,   Elsevier: Scopus)
145. Yasomi Handa, Minoru Higashimoto, 俣野 景典, Akira Tokumura and Hiroaki Tsukatani :
市販リン脂質中のグリセリン酸の分解,
Journal of the Pharmaceutical Society of Japan, Vol.101, 749-752, 1981.
146. Akira Tokumura, Kenji Fukuzawa, S Yamada and Hiroaki Tsukatani :
Stimulatory effect of lysophosphatidic acids on uterine smooth muscles of non-pregant rats,
Archives internationales de Pharmacodymie et de Therapie, Vol.245, No.1, 74-83, 1980.
(PubMed: 6902643)
147. hiroaki Tsukatani, Sadaji Yamada, Akira Tokumura, Takafumi Itami and Kenkichi Takauchi :
Occurrence of short-duration hypotensive phospholipid from dog peritoneal dialysate,
Journal of Pharmaceutical Sciences, Vol.68, No.11, 1426-1429, 1979.
(DOI: 10.1002/jps.2600681124,   PubMed: 512894,   Elsevier: Scopus)
148. Hiroaki Tsukatani, Sadaji Yamada, Akira Tokumura and T Itami :
Action of depressor-I, a hypotensive phospholipid from bovine brain, on systemic and arterial blood pressures of various species,
The Japanese Journal of Pharmacology, Vol.29, No.5, 695-705, 1979.
(PubMed: 295088)
149. Hiroaki Tsukatani, Sadaji Yamada, Akira Tokumura, Kenkichi Takauchi and T Itami :
A hypotensive phospholipid from dog peritoneal dialysate,
The Journal of Pharmacy and Pharmacology, Vol.31, No.8, 569-571, 1979.
(PubMed: 40007)
150. Kenji Fukuzawa, H Ikeno, Akira Tokumura and Hiroaki Tsukatani :
Effect of α-tocopherol incorporation on glucose permeability and phase transition of lecithin liposomes,
Chemistry and Physics of Lipids, Vol.23, No.1, 13-22, 1979.
(DOI: 10.1016/0009-3084(79)90019-7,   PubMed: 445689,   Elsevier: Scopus)
151. Hiroaki Tsukatani, Sadaji Yamada, Kenkichi Takauchi, Akira Tokumura, H Tatsumichi and K Kumegawa :
Physico-chemical characteristics of D-I, a hypotensive factor occurred in acetone extract of the bovine brain,
Chemical & Pharmaceutical Bulletin, Vol.26, No.11, 3281-3288, 1978.
(PubMed: 729116,   Elsevier: Scopus)
152. Akira Tokumura, Kenji Fukuzawa and Hiroaki Tsukatani :
Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species,
Lipids, Vol.13, No.8, 572-574, 1978.
(DOI: 10.1007/BF02533598,   PubMed: 703535)
153. Akira Tokumura, Kenji Fukuzawa, Yasue Akamatsu, Sadaji Yamada, Tetsuya Suzuki and Hiroaki Tsukatani :
Identification of vasopressor phospholipid in crude soybean lecithin,
Lipids, Vol.13, No.7, 468-472, 1978.
(DOI: 10.1007/BF02533615,   PubMed: 567731,   Elsevier: Scopus)
154. Kenji Fukuzawa, Akira Tokumura, Sadaji Yamada and Hiroaki Tsukatani :
Oral Toxicity of Sodium Dodecyl Sulfate,
Japanese Journal of Toxicology and Environmental Health, Vol.24, No.2, 107-110, 1978.
(DOI: 10.1248/jhs1956.24.107,   CiNii: 110003642701,   Elsevier: Scopus)
155. Akira Tokumura, Yasue AKAMATSU, Sadaji YAMADA and Hiroaki TSUKATANI :
Chemical and pharmacological properties of vasopressor phospholipid in crude soybean lecithin,
Agricultural and Biological Chemistry, Vol.42, No.3, 515-521, 1978.
(DOI: 10.1271/bbb1961.42.515,   CiNii: 130003525976)
156. Hiroaki Tsukatani, Sadaji Yamada, Akira Tokumura, T Miyamoto and Kenkichi Takauchi :
Isolation of an acute hypotensive substance from bovine brain lipid fraction,
Chemical & Pharmaceutical Bulletin, Vol.24, No.10, 2294-2300, 1976.
(PubMed: 1017075)
157. Kenji Fukuzawa and Akira Tokumura :
Glutathione peroxidase activity in tissues of vitamin E-deficient mice,
Journal of Nutritional Science and Vitaminology, Vol.22, No.5, 405-407, 1976.
(PubMed: 1011051)
158. Mitsuri Fukuda, Akira Tokumura, Tadashi Ogawa and Kei Sakaoka :
D-Alanine in germinating Pisum sativum seedlings,
Phytochemistry, Vol.12, No.11, 2593-2595, 1973.
(DOI: 10.1016/0031-9422(73)85061-7,   Elsevier: Scopus)
159. K Takeo, Akira Tokumura and T Kuge :
Complexes of starch and its related materials with organic compounds. Part X, X-ray diffraction of amylose-fatty acid complexes,
Starke, Vol.25, No.11, 357-362, 1973.
(DOI: 10.1002/star.19730251102)

Academic Paper (Unrefereed Paper):

1. Junichi Morishige, Hideko Nagasawa, Hitoshi Hori, Kenji Fukuzawa and Akira Tokumura :
ニワトリ卵白のリゾホスホリパーゼDによるリゾホスファチジン酸の産生,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.48, No.0, 91-94, 2006.
(CiNii: 10024354781)
2. Akira Tokumura, 土江 明子, 平良 智, 黒川 ふみ and Kenji Fukuzawa :
喫煙による循環血液での酸化リン脂質の産生ー血管病変への関与の可能性ー,
平成17年度喫煙科学研究財団研究年報, 321-326, 2006.
3. Akira Tokumura, 土江 明子, 平良 智 and Kenji Fukuzawa :
喫煙による循環血液での酸化リン脂質の産生ー血管病変への関与の可能性ー,
平成16年度喫煙科学研究財団研究年報, 334-348, 2005.
4. Akira Tokumura, 土江 明子, 平良 智 and Kenji Fukuzawa :
ウサギ房水のリゾホスホリパーゼD活性によるリゾホスファチジルコリンの分解,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.46, 69-72, 2004.
5. Kenji Fukuzawa, Kentaro Kogure, 中島 佐和, 土江 明子 and Akira Tokumura :
リン脂質酸化二次作物による血管平滑筋細胞のアポトーシス誘導とビタミンEによる抑制作用,
ビタミンE研究の進歩Ⅺ, 115-127, 2004.
6. 真鍋 幸恵, Kentaro Kogure, 森田 健之, Akira Tokumura and Kenji Fukuzawa :
抗ガン作用の増強を志向したビタミンEコハク酸ベシクル,
ビタミンE研究の進歩Ⅺ, 45-49, 2004.
7. Akira Tokumura, 土江 明子, 平良 智 and Kenji Fukuzawa :
喫煙による循環血液での酸化リン脂質の産生ー血管病変への関与の可能性ー,
平成15年度喫煙科学研究財団研究年報, 320-325, 2004.
8. Akira Tokumura :
Proinflammatory platelet activating factor-like phospholipids and their pathophysiological significance,
Chemistry and Physics of Lipids, Vol.130, No.1, 18-20, 2004.
9. Akira Tokumura, 平尾 恵理, 丸山 祐史, Kentaro Kogure, Kenji Fukuzawa, 安田 勝彦 and 神崎 秀暢 :
正常および異常妊娠時のヒト血清リゾホスホリパーゼD活性,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.45, No.0, 95-97, 2003.
(CiNii: 10024570625)
10. Akira Tokumura, 富永 恭子, Kentaro Kogure, Kenji Fukuzawa, 安田 勝彦, 刈谷 優子 and 真島 英司 :
生理活性リン脂質LPAを産生するヒト血漿リゾホスホリパーゼDは多機能性ヌクレオチドホスジエステラーゼautotaxinである,
脂質生化学研究, Vol.44, 78-881, 2002.
11. Akira Tokumura, 富永 恭子, 金谷 由美, Kentaro Kogure and Kenji Fukuzawa :
モルモット腹腔洗浄液のリゾホスホリパーゼD活性,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.43, 82-85, 2001.
(CiNii: 10013379143)
12. Kenji Fukuzawa, Kentaro Kogure, M Morita, S Hama, S Nakashima and Akira Tokumura :
Enhancement by α-tocopherol hemisuccinate of nitric oxide production induced by lipopolysaccharide and interferon-γ through up-regulation of protein kinase C in rat vascular smooth muscle cells,
Proc.Of the second China-Japan international Conference on Vitamins, 262-267, 2001.
13. Takayuki Sugiura, Keizo Waku and Akira Tokumura :
Acyl and alkyl ether-linked lysophosphatidic acids in the nervous system,
Annals of the New York Academy of Sciences, Vol.905, 351-353, 2000.
(DOI: 10.1111/j.1749-6632.2000.tb06577.x,   PubMed: 10818481,   Elsevier: Scopus)
14. Akira Tokumura, Shuji Yamano, Toshihiro Aono and Kenji Fukuzawa :
Lysophosphatidic Acids Produced by Lysophospholipase D in Mammalian Serum and Body Fluid,
Annals of the New York Academy of Sciences, Vol.905, 347-350, 2000.
(DOI: 10.1111/j.1749-6632.2000.tb06576.x,   PubMed: 10818480,   Elsevier: Scopus)
15. Akira Tokumura, 金谷 由美, 富永 恭子, Kentaro Kogure, Kenji Fukuzawa, 北原 真樹 and 安田 勝彦 :
血清リゾホスホリパーゼDによるリゾホスファチジン酸産生の病態下での変動,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.42, 41-44, 2000.
16. Akira Tokumura, 四宮 淳也, Kentaro Kogure, Kenji Fukuzawa, 田中 保 and 里内 清 :
高度不飽和脂肪酸を有するリゾホスファチジン酸:血漿中での生成と血小板凝集活性,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.41, 193-195, 1999.
17. Akira Tokumura, 住田 常喜, 東嶋 祐興, Kenji Fukuzawa, Shuji Yamano and Toshihiro Aono :
リポキシゲナーゼによるホスファチジルコリンの酸化分解,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.40, 235-238, 1998.
18. Kenji Fukuzawa, 権藤 直人, Akira Tokumura, Satoru Ueno and 柴田 螢 :
スーパーオキシド依存症の脂質過酸化を誘導する発癌性鉄錯体Fe-NTA(ニトリロ三酢酸)の特性,
フリーラジカルの臨床, Vol.12, 70-76, 1997.
19. Kenji Fukuzawa, 松浦 佳代, 鳥居 真由美, Akira Tokumura, 柴田 螢, 鈴木 旭 and Junji Terao :
リボソーム膜におけるα-トコフェロールの一重項酸素脱活作用:反応速度定数の測定,
ビタミンE研究の進歩Ⅶ, 6-14, 1997.
20. Akira Tokumura, 三宅 真樹, Kenji Fukuzawa, Shuji Yamano and Toshihiro Aono :
妊婦血清リボホスホリパーゼD活性,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.39, 43-45, 1997.
21. 松浦 佳代, Kenji Fukuzawa, Akira Tokumura, 市川 久次 and Takenori Kusumi :
α-トコフェロールの立体異性体の分離および微量定量,
ビタミンE研究の進歩Ⅵ, Vol.6, 29-33, 1996.
22. 家村 雅仁, 高橋 香織, Akira Tokumura and Kenji Fukuzawa :
Fe2+/アスコルビン酸系ーおよびFe3+錯体/キサンチンオキシダーゼ系ー膜脂質過酸化反応の比較検討,
過酸化脂質研究, Vol.20, 240-243, 1996.
23. Akira Tokumura :
低密度リポタンパクの過酸化により生じる血小板活性化因子様リン脂質,
杉山産業化学研究所年報, 69-84, 1996.
24. 堤 敏彦, 鈴木 和寿, 南 武夫, 北澤 式文 and Akira Tokumura :
アルキルエテール型リン脂質1-O-octadecyl-2-O-methyl-glycero-3-phosphocholine及びその類似体の細胞内動態,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.38, 255-258, 1996.
25. Akira Tokumura, 吉本 修, 三宅 真樹 and Kenji Fukuzawa :
ラット血漿のリゾホスファチジン酸生成康酵素活性,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.38, 251-254, 1996.
26. Akira Tokumura, 東嶋 祐興 and Kenji Fukuzawa :
LDLの過酸化により生成するPAF様脂質の分解,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.37, 203-206, 1995.
27. Akira Tokumura, Tamotsu Tanaka and Hiroaki Tsukatani :
Characterization of PAF-like phospholipids formed by lipid peroxidation,
Journal of Lipid Mediators and Cell Signalling, Vol.10, 179-181, 1994.
28. J Donald Hanahan, Takayuki Sugiura, L Gregory, Teri Nouchi and Akira Tokumura :
Phosphoric acid analogs of PAF,
Journal of Lipid Mediators and Cell Signalling, Vol.10, 169-170, 1994.
29. Akira Tokumura, 飯森 信, 西岡 優子, 北原 真樹, 坂下 光明 and 田中 作彌 :
保温血漿および卵胞液に存在するリゾホスファチジン酸の生成機構,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.36, 23-26, 1994.
30. Akira Tokumura, 飯森 信, 西岡 優子, 北原 真樹, 坂下 光明 and 田中 作彌 :
リゾホスファチジン酸のラット培養血管平滑筋細胞増殖作用,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.35, 259-262, 1993.
31. 田中 保, 畝崎 佐和子, Akira Tokumura and 塚谷 博昭 :
脂質過酸化反応により派生するPAF様リン脂質の構造解析,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.34, 297-300, 1992.
32. 堤 敏彦, Akira Tokumura and 塚谷 博昭 :
アルキルエーテル型ホスファチジン酸の好中球における膜内動態,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.33, 193-196, 1991.
33. 田中 保, 四元 孝志, Akira Tokumura and 塚谷 博昭 :
ウシ脳組織中のPAF構造類似体:GC-MSによるα-ヒドロキシカルボン酸含有リン脂質の同定,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.32, 263-266, 1990.
34. Kenji Fukuzawa, T Hiramoto, T Fujii, K Kishikawa and Akira Tokumura :
Lipid peroxidation induced by hydroxyl-and lipid free-radicals and iron-oxygen complexes,and its inhibition by a-tocopherol,
Medical,Biochemical and Chemical Aspects of Free Radicals, 275-278, 1989.
35. Kenji Fukuzawa, Yasuhiro Kurotori, Akira Tokumura and Hiroaki Tsukatani :
Increased platelet-activating factor (PAF) synthesis in polymorphonuclear leukocytes of vitamin E-deficient rats,
Annals of the New York Academy of Sciences, Vol.570, 449-454, 1989.
36. Akira Tokumura, 高内 健吉, 吉田 淳一, 浅井 剛, Kenji Fukuzawa, 塚谷 博昭 and 小川 正 :
脳組織中のPAF及び関連リン脂質類,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.30, 384-386, 1988.
37. Akira Tokumura, 堤 敏彦, 吉田 淳一, Kenji Fukuzawa and 塚谷 博昭 :
PAFとそのリゾ体の血小板および好中球での膜内動態,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.30, 295-298, 1988.
38. Kenji Fukuzawa, 藤井 智仁, 田所 豊博, Akira Tokumura and 塚谷 博昭 :
[Fe2+錯体ー酸素]複合体によるリノール酸の過酸化誘導とα-トコフェロール(α-Toc)の抗酸化作用,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.29, 413-416, 1987.
39. Akira Tokumura, 上安 功明, 浅井 剛, Kenji Fukuzawa and 塚谷 博昭 :
ウシ脳組織中のPAF分子種の同定並びに定量,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.29, 333-336, 1987.
40. Akira Tokumura, 吉田 淳一, 丸山 隆幸, Kenji Fukuzawa and 塚谷 博昭 :
血小板表面におけるエーテル結合型リン脂質の作用様式,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.28, 57-60, 1986.
41. Hiroaki Tsukatani, Junichi Yoshida, Akira Tokumura and Kenkichi Takauchi :
Occurrence of new hypotensive and platelet-activating substances in bovine brain,
Adv.Prostaglandins Thomboxane Leukotriene Res., Vol.15, 721-722, 1985.
42. Akira Tokumura, 原田 研吾, Yasuko Yoshioka and 塚谷 博昭 :
リゾホスファチジン酸のトリメチルシリル体のGC-MS分析,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.25, 360-363, 1983.
43. Kenji Fukuzawa, 大内 節博, Akira Tokumura and 塚谷 博昭 :
リポソーム膜におけるビタミンE同族体の脂質抗酸化作用,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.23, 61-65, 1981.
44. Kenji Fukuzawa, 千田 尚子, Akira Tokumura and 塚谷 博昭 :
リポソーム膜における脂質過酸化反応とビタミンE,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.22, 229-232, 1980.
45. Akira Tokumura, 久米 哲也, Kenji Fukuzawa and 塚谷 博昭 :
リゾホスファチジン酸及びその構造類似体の心血管作用,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.22, 190-194, 1980.
46. Kenji Fukuzawa, Akira Tokumura, 池野 宏彦, 塚谷 博昭 and 鈴木 旭 :
膜流動性および相転移に及ぼすトコフェロールの効果,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.21, 94-97, 1979.
47. Akira Tokumura, Kenji Fukuzawa, 赤松 康江, 山田 貞二, 塚谷 博昭 and 鈴木 鉄也 :
市販大豆レシチン中の血圧活性脂質の単離と同定,
Proceedings of the Japanese Conference on the Biochemistry of Lipids, Vol.20, 157-160, 1978.

Academic Letter:

1. Toshihiko Tsutsumi, Mika Adachi, Miki Nikawadori, Junichi Morishige and Akira Tokumura :
Presence of bioactive lysophosphatidic acid in renal effluent of rtas with unilateral ureteral obstruction,
Life Sciences, Vol.89, No.5-6, 195-203, 2011.
(DOI: 10.1016/j.lfs.2011.06.001,   PubMed: 21693124,   Elsevier: Scopus)
2. Mika Adachi, Goh Horiuchi, Natsuki Ikematsu, Tamotsu Tanaka, Junji Terao, Kiyoshi Satouchi and Akira Tokumura :
Intragastrically aministered lyophosphatidic acid protct against gastric ulcer in rats under water-immersion restraint stress,
Digestive Diseases and Sciences, Vol.56, No.8, 2252-2261, 2011.
(DOI: 10.1007/s10620-011-1595-0,   PubMed: 21298479,   Elsevier: Scopus)

Review, Commentary:

1. Akira Tokumura, Manami Inoue and Mika Adachi :
リゾホスファチジン酸濃縮食品の開発に関する基礎研究,
ニューフードインダストリー, Vol.54, No.11, 1-6, Nov. 2012.
(CiNii: 40019473145)
2. 清水 嘉文 and Akira Tokumura :
Physiological role of lysophosphatidic acid and its relevance to diseases,
Seikagaku, Vol.83, No.6, 506-517, Jun. 2011.
(PubMed: 21800681,   CiNii: 10029069008,   Elsevier: Scopus)
3. Akira Tokumura :
生殖器官におけるリゾ脂質メディエーターの役割,
The Cell, Vol.42, 12-15, 2010.
4. Akira Tokumura :
Phosphodiesterases that extracellularly produces a lysolipid mediator,
Seikagaku, Vol.78, No.12, 1141-1154, Dec. 2006.
(PubMed: 17243635,   CiNii: 10018675562)
5. 成重 純一, Akira Tokumura and Kenji Fukuzawa :
リゾホスファチジン酸による肥満亢進抑制作用,
ビタミン, Vol.79, No.12, 593-594, Dec. 2005.
(CiNii: 110004857286)
6. Akira Tokumura :
Metabolic pathways and physiological and pathophysiological significances of lysolipid phosphate mediators,
Journal of Cellular Biochemistry, Vol.92, No.5, 869-881, Jun. 2004.
(DOI: 10.1002/jcb.20147,   PubMed: 15258912,   Elsevier: Scopus)
7. Kenji Fukuzawa, Kentaro Kogure, Motoki Morita, Susumu Hama and Akira Tokumura :
Enhancement of Nitric Oxide and Superoxide Generations by α-Tocopheryl Succinate and Its Apoptotic and Anticancer Effects,
Biochemistry (Moscow), Vol.69, No.1, 50-57, Jan. 2004.
(DOI: 10.1023/B:BIRY.0000016351.77553.74,   PubMed: 14972018,   Elsevier: Scopus)
8. 土江 明子, Akira Tokumura and Kenji Fukuzawa :
喫煙が血液中で悪玉酸化リン脂質をつくる,
ビタミン, Vol.77, No.3, 167-169, Mar. 2003.
(CiNii: 110002843090)
9. Akira Tokumura, A. Tuchie, M. Imasaki and Kenji Fukuzawa :
Generation of platelet-activating factor (PAF)-like phospholipids in blood circulation under elevated oxidative stress:its pathological significance on atherosclerosis,
Journal of Clinical Biochemistry and Nutrition, Vol.34, No.1, 35-42, 2003.
(DOI: 10.3164/jcbn.34.35,   Elsevier: Scopus)
10. Akira Tokumura :
Examination by GC/MS of Mechanism for Production of Phospholipid Mediators,
Journal of the Mass Spectrometry Society of Japan, Vol.50, No.3, 100-107, Jun. 2002.
(DOI: 10.5702/massspec.50.100,   CiNii: 10010123185)
11. Akira Tokumura :
Physiological and pathophysiological roles of lysophosphatidic acid produced by secretory lysophospholipase D in body fluids,
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol.1582, No.1-3, 18-25, May 2002.
(DOI: 10.1016/S1388-1981(02)00133-6,   PubMed: 12069806,   Elsevier: Scopus)
12. 土江 明子, Akira Tokumura, Kentaro Kogure and Kenji Fukuzawa :
喫煙が血液中で悪玉リン脂質をつくるー動脈硬化との関連ー,
日本薬学会 第122年会講演ハイライト, 22, 2002.
13. Kenji Fukuzawa and Akira Tokumura :
Kinetics and Dynamics of α-Tocopherol and Carotenoids for Deactivating Singlet Oxygen in Phospholipid Membranes,
ビタミン, Vol.75, No.1, 1-13, Jan. 2001.
(CiNii: 110002883428)
14. Akira Tokumura and Kenji Fukuzawa :
リン脂質過酸化の二次生成物が特異的受容体に作用して動脈硬化の進展に寄与する,
ビタミン, Vol.74, No.3, 145-158, Mar. 2000.
(CiNii: 110002844022)
15. Akira Tokumura, Tuneki Sumida, Masaoki Toujima, Kentaro Kogure and Kenji Fukuzawa :
Platelet-activating factor (PAF)- like oxidized phospholipids: relevance to atherosclerosis,
BioFactors, Vol.13, No.1-4, 29-33, 2000.
(PubMed: 11237195,   Elsevier: Scopus)
16. Akira Tokumura :
A family of phospholipid autacoids: occurrence, metabolism and bioactions,
Progress in Lipid Research, Vol.34, No.2, 151-184, 1995.
(DOI: 10.1016/0163-7827(95)00001-G,   PubMed: 7480064,   Elsevier: Scopus)
17. Akira Tokumura :
脂質過酸化と新規生理活性リン脂質,
Journal of the Agricultural Chemical Society of Japan, Vol.68, No.6, 1050-1051, Jun. 1994.
(CiNii: 110002794813)
18. Akira Tokumura, Tamotsu Tanaka and Hiroaki Tsukatani :
Characterization of PAF-like phospholipids formed by lipid peroxidation,
Journal of Lipid Mediators and Cell Signalling, Vol.10, 179-181, 1994.
19. Akira Tokumura and 塚谷 博昭 :
血小板活性化因子(PAF),
New Horizon for Medicine, Vol.25, 985-1027, 1993.
20. Akira Tokumura, Tamotsu Tanaka, Takashi Yotsumoto and Hiroaki Tsukatani :
Formation of PAF-like compounds by peroxidation of phospholipids from bovine brain,
Journal of Lipid Mediators, Vol.5, No.2, 127-130, 1992.
(PubMed: 1525352,   Elsevier: Scopus)
21. Akira Tokumura :
PAFの病態生理学的役割 神経系,
The Medical Frontline, Vol.45, No.3, 505-511, Mar. 1990.
22. Akira Tokumura :
血小板活性化因子(PAF)の中枢における役割,
Farumashia, Vol.25, No.7, 720-721, Jul. 1989.
(CiNii: 110003658974)
23. Akira Tokumura and 塚谷 博昭 :
GC/MS による活性リン脂質の構造解析,
日本医用マススペクトル学会誌, Vol.14, 31-38, 1989.
24. Akira Tokumura :
新しい化学伝達物質PAFと細胞活性化,
Medicine and Drug Journal, Vol.25, No.2, 65-70, 1989.
25. Akira Tokumura and 塚谷 博昭 :
血小板活性化因子の拮抗薬,
Seikagaku, Vol.57, No.12, 1618-1623, Dec. 1985.
(CiNii: 40002015058)
26. Kenji Fukuzawa, 千田 尚子, 大内 節博, Akira Tokumura and 塚谷 博昭 :
リポソーム膜においてアスコルビン酸-Fe2+により誘導される脂質過酸化反応に対するトコフェロールの抗酸化作用,
ビタミン, Vol.56, 641-652, 1982.
27. Akira Tokumura :
薬理活性をもつリゾリン脂質,
化学と生物, Vol.15, 709-711, 1977.

Proceeding of International Conference:

1. Tamotsu Tanaka, 盛重 純一, 近藤 宏樹, 木下 正文, 足立 美佳, 瓜倉 真衣, 里内 清 and Akira Tokumura :
Formation of lysophosphatidic acid, a wound-healing lipid, during digestion of cabbage leaves,
Keystone Symposia, Bioactive lipids: Biochemistry & Diseases, Abstract Book, 105, 京都, Jun. 2010.
2. Mika Adachi, Jun-ichi Morishige, Tamotsu Tanaka, Junji Terao, Kiyoshi Satouchi and Akira Tokumura :
Lysophosphatidic acid in foods and herbs protects gastric ulcer in rats under water-immersion stress,
4th international conference on phospholipase A2 and lipid mediators, Vol.Final program and abstracts book, 131, Tokyo, May 2009.
3. Akira Tokumura, Emi Kuwahara, Junichi Morishige, Kenji Fukuzawa and Shuji Yamano :
Physiological and pathophysiological roles of lysophosphatidic acid production by by lysophospholipase D in the reproductive system,
3rd International Conference on phospholipase A2 and lipid mediators, Sorrento, May 2007.
4. Junichi Morishige, Kenji Fukuzawa, Hideko Nagasawa, Hitoshi Hori and Akira Tokumura :
Lysophosphatidic acid produced by lysophospholipase D in hen egg white induces blood vessel formation on hen chorioallantoic membrane,
3rd International Conference on phospholipase A2 and lipid mediators, Sorrento, May 2007.
5. Akira Tokumura, Satoshi Taira, Kenji Fukuzawa, Toshihiko Tsutsumi, Tomoya Kitayama, K Morita and Toshihiro Dohi :
LC-MS analysis on productions of bioactive lysophosphatidic acids from lysophosphatidylcholines in human mixed saliva,
47th International Conference on theBioscience of Lipids, Pecos, Sep. 2006.
6. Kenji Fukuzawa, A. Fujiwara, Akira Tokumura, Junji Terao and Jansuz M. Gebicki :
Measurement of phosphatidylcholine hydroperoxides in membranes by the ferric-xylenol orange (FOX) assay,
XIII the Biennial Meeting of the Society for Free Radical Research International, Davos, Aug. 2006.
7. Kenji Fukuzawa, Akira Shibata, Koichiro Tsuchiya, Akira Tokumura, H. Ichikawa and Jansuz M. Gebicki :
Colored complex of ferric-xylenol orange/phosphatidylcholine vesicle in the Fox assay,
XIII the Biennial Meeting of the Society for Free Radical Research International, Davos, Aug. 2006.
8. Kenji Fukuzawa, Kentaro Kogure, Sachie Manabe and Akira Tokumura :
In vitro cytotoxicity of alpha-tocopherol succinate, malonate and oxalate on cancer cells and their in vivo anti-cancer effects on mouse melanoma,
XIII the Biennial Meeting of the Society for Free Radical Research International, Davos, Aug. 2006.
9. Akira Tokumura, Emi Kuwahara, Junichi Morishige, Kenji Fukuzawa and Shuji Yamano :
Lysophosphatidic acid stimulates hyaluronic acid production in mouse oocyte-cumulus cells complex in vitro,
20thIUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Kyoto, Jun. 2006.
10. Tamotsu Tanaka, Goh Horiuti, Kaoru Hirano, Junichi Morishige, Akira Tokumura and Kiyoshi Satouchi :
Pccurrence pf lysophosphatidic acids in herbs,
20thIUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Kyoto, Jun. 2006.
11. Kenji Fukuzawa, Kentaro Kogure, S. Manabe, Ichiro Suzuki and Akira Tokumura :
Selective cytotoxicity to cancer cells of α-tocopheryl succinate analogues in vitro and their anti-cancer effects on mouse melanoma in vivo,
International Interdisciplinary Conference on Vitamins, Coenzymes, and Biofactors 2005, Awaji, Hyogo, Nov. 2005.
12. Koichiro Tsuchiya, Kaori Akai, Akira Tokumura, Shinji Abe, Toshiaki Tamaki, Yoshiharu Takiguchi and Kenji Fukuzawa :
Oxygen Radicals Photo-induced by Ferric Nitrilotriacetate(FE-NTA) Complex,
EPR 2005, Columbus, OH, Sep. 2005.
13. K. Tsuchiya, K. Akai, Akira Tokumura, S. Abe, T. Tamaki, Y. Takiguchi and Kenji Fukuzawa :
Oxygen radicals photo-induced by ferric nitrilotriacetate(Fe-NTA) complex,
EPR 2005. The international Conference/Workshop on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems, Ohio,U.S.A., Sep. 2005.
14. Akira Tokumura, S. Taira, J. Morishige, T. Tsutsumi and Kenji Fukuzawa :
Lysophospholipase C and D produce lysolipids that may intercellularly mediate signals from mammalian cell lines,
46th International Conference on the Bioscience of Lipids, Ajaccio-Corsica, Sep. 2005.
15. M. Watsky, W. Hatsuyama, T. Tsutsumi, Kenji Fukuzawa and Akira Tokumura :
Lysophospholipase D and elevates lysophosphatidylcholine as sources of elevated aqeous humor LPA following corneal injury,
ARVO 2005 Annual Meeting, Fort Lauderdale, Florida,U.S.A., May 2005.
16. Tamotsu Tanaka, K. Hirano, T. Koike, Akira Tokumura and K. Satouchi :
Quantitative analysis of lysophosphatidic acid by matrix-assisted laser desorption time-of-flight mass spectrometry using a phosphate capture molecule,
2nd International Conference Phospholipase A2 and 8th International Congress Platelet-activating Factor and Related Lipid Mediators, 204, Berlin, Oct. 2004.
17. Akira Tokumura, C. Kageyama, W. Hatuyama, S. Taira, K. Touchika and Kenji Fukuzawa :
Lysophosphatidic acid production by secretory lysophosholipase D:Physiological implications,
2nd International Conference on Phospholipase A2 and 8th International congress on Platelet-Activating Factor and Related Lipid Mediators, Berlin, Oct. 2004.
18. Kenji Fukuzawa, Kentaro Kogure, M. Morita, S. Hama and Akira Tokumura :
Enhancement by alpha-tocopheryl succinate of superoxide and nitric oxide generations in cultured cells,
International Symposium: Reactive Oxygen and Nitrogen Species: Diagnostic,Preventive and Therapeutic Values, St. Petersburg-Kizhi-St.Petersburg Russia, Jul. 2002.
19. Akira Tokumura, A. Tsuchie, Kentaro Kogure and Kenji Fukuzawa :
Cigarette smoking increases plasma level of phosphatidylcholine having an oxidatively shortened fatty acyl group with a carboxyl terminal,
11th Biennial Scientific Meeting of the International Society for Free Radical Research, Paris, Jul. 2002.
20. Kentaro Kogure, S. Hama, S. Manabe, M. Kisaki, Akira Tokumura and Kenji Fukuzawa :
High toxicity of α-tocopheryl succinate to cancer cells is due to their failed antioxidative deffence system,
11th Biennial Scientific Meeting of the International Society for Free Radical Research, Paris, Jul. 2002.
21. Kenji Fukuzawa, Y. Saitoh, K. Arai, Kentaro Kogure, Akira Tokumura and A. Shibata :
Antioxidant effect of bovine serum albumin on iron-chelate superoxide-dependent membrane lipid peroxidation,
11th Biennial Scientific Meeting of the International Society for Free Radical Research, Paris, Jul. 2002.
22. Kentaro Kogure, S. Hama, S. Manabe, Ichiro Suzuki, M. Shibuya, Akira Tokumura and Kenji Fukuzawa :
Role of terminal structure of a-tocopheryl esters in nitric oxide production and apoptosis,
The 9th Korea-Japan joint symposium of drug design and development, Seoul, May 2002.
23. S. Hama, Kentaro Kogure, S. Manabe, Akira Tokumura and Kenji Fukuzawa :
Anti-cancer effect of a-tocopheryl succinate mediated by apoptosis,
The 9th Korea-Japan joint symposium of drug design and development, Seoul, May 2002.
24. K. Tominaga, Kentaro Kogure, Kenji Fukuzawa and Akira Tokumura :
Property of secretory phospholipase D which generates bioactive lysophosphatidic acid in guinea-pig peritoneal washing,
The 1st Takeda Science Foundation Symposium on Pharma Sciences:Lipids in Signaling and Related Diseases, Tokyo, Oct. 2001.
25. Kentaro Kogure, M. Morita, S. Nakashima, S. Hama, Akira Tokumura and Kenji Fukuzawa :
Superoxide is responsible for apoptosis in rat vascular smooth muscle cells induced by α-tocopheryl hemisuccinate,
2nd China-Japan International Conference on Vitamins, Shanghai, Oct. 2001.
26. Kenji Fukuzawa, Kentaro Kogure, M. Morita, S. Hama, S. Nakashima and Akira Tokumura :
Enhancement by α-tocopheryl hemisuccinate of nitric oxide production indeced by lipopolysaccharide and interferon-γthrough up-regulation of protein kinase C in rat vascular smooth muscle cells,
2nd China-Japan International Conference on Vitamins, Shanghai, Oct. 2001.

Proceeding of Domestic Conference:

1. 坪井 一人, 井上 愛美, 岡本 蓉子, 日高 麻由美, 宇山 徹, 堤 敏彦, Tamotsu Tanaka, 岡本 安雄, 上田 夏生 and Akira Tokumura :
N-アシル-ホスファチジルエタノールアミン特異的ホスホリパーゼD欠損マウスの末梢臓器における関連脂質とその代謝経路の解析,
第91回 日本生化学大会, Sep. 2018.
2. 堤 敏彦, 井上 愛美, 岡本 蓉子, 渥美 祐太, 塩尻 正俊, 日高 麻由美, Tamotsu Tanaka, 白坂 直輝 and Akira Tokumura :
食餌への高濃度のリゾホスファジン酸添加はマウスの体重と体脂肪を減少させる,
第91回 日本生化学大会, Sep. 2018.
3. Afroz Sheuli, Katsuya Morito, Kouki Fujikawa, Ayano Yagi, Kazunori Toida, Emi Kiyokage, Kentaro Kogure, Shiro Watanabe, Akira Tokumura and Tamotsu Tanaka :
Antiulcer effect of lysophosphatidic acid-rich medicinal herbs and its mechanism,
第40回日本分子生物学会年会,第90回日本生化学会大会 プログラム, 439, Dec. 2017.
4. Ayano Yagi, Afroz Sheuli, 生駒 照, Akira Tokumura, Kentaro Kogure and Tamotsu Tanaka :
食物中のホスファチジン酸の抗胃潰瘍効果とホスホリパーゼA2活性化作用.,
第55回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会(岡山), Oct. 2016.
5. 坪井 一人, Iffat Sonia Ara Rahman, 岡本 蓉子, 宇山 徹, Naoshi Yamazaki, Tamotsu Tanaka, Akira Tokumura and 上田 夏生 :
GDE7はリゾホスホリパーゼD型酵素としてN-アシルエタノールアミンとLPAを生成する,
第89回日本生化学会大会, Sep. 2016.
6. 山下 量平, 伊賀 永里奈, 柿内 直哉, 辻 和樹, 小暮 健太郎, Akira Tokumura, Michiyasu Nakao, Shigeki Sano and Tamotsu Tanaka :
種々のセラミド-1-リン酸分子種の生理活性とその代謝,
第58回日本脂質生化学会, Jun. 2016.
7. 松田 璃沙, 坪井 一人, 岡本 蓉子, 山下 量平, Rahman Ara Sonia Iffat, 日高 麻由美, Naoshi Yamazaki, 上田 夏生, Tamotsu Tanaka and Akira Tokumura :
口腔粘膜上皮細胞に存在する膜結合型リゾホスホリパーゼD,
第58回日本脂質生化学会, Jun. 2016.
8. Iffat Sonia Ara Rahman, Kazuhito Tsuboi, Yoko Okamoto, Toru Uyama, Naoshi Yamazaki, Tamotsu Tanaka, Akira Tokumura and Natsuo Ueda :
Glycerophosphodiesterases, GDE4 and GDE7, are novel lysophospholipase D-type enzymes generating N-acylethanolamine and LPA,
第57回日本生化学会 中国四国支部例会, May 2016.
9. 山下 量平, 柿内 直哉, 伊賀 永里奈, 田畑 優美香, 島田 明奈, Akira Tokumura and Tamotsu Tanaka :
種々のマウス組織におけるセラミド-1-リン酸分子種とその代謝,
日本農芸化学会中四国支部第44回公演会 要旨集, 41, Jan. 2016.
10. Sheuli Afroz, Teru Ikoma, Ayano Yagi, Shiro Watanabe, Akira Tokumura and Tamotsu Tanaka :
Effect of phosphatidic acid on NSAIDs-induced stomach ulcer and its content in cereals,
日本農芸化学会中四国支部第44回公演会 要旨集, 33, Jan. 2016.
11. 清水 良多, 魚住 幸加, 森戸 克弥, 大隅 隆, Akira Tokumura and Tamotsu Tanaka :
脂肪酸鎖長の伸長と短縮反応におけるペルオキシソームの役割(口頭発表選出),
第88回日本生化学会大会, Dec. 2015.
12. 辻 和樹, 伊藤 葵, 木村 朱里, 松岡 久嗣, 藤原 美奈, 喜田 孝史, 今井 博之, Akira Tokumura and Tamotsu Tanaka :
植物に見出されたグリコシルイノシトールホスホセラミド特異的ホスホリパーゼDの性状と分布,
第88回日本生化学会大会, Dec. 2015.
13. 柿内 直哉, 山下 量平, 田畑 優美香, 伊賀 永里奈, 島田 明奈, 辻 一樹, Akira Tokumura and Tamotsu Tanaka :
種々のマウス組織におけるセラミド-1-リン酸分子種とその代謝,
第88回日本生化学会大会, Dec. 2015.
14. Afroz Sheuli, 生駒 照, 屋宜 彩乃, Akira Tokumura and Tamotsu Tanaka :
Effect of phosphatidic acid on indomethacin-induced stomach ulcer and its content in plant sources,
第88回日本生化学会大会, Dec. 2015.
15. 藤川 昂樹, 生駒 照, 森戸 克弥, 清蔭 恵美, 徳田 一徳, Taro Shimizu, Tatsuhiro Ishida, Akira Tokumura and Tamotsu Tanaka :
ヒト胃由来培養細胞におけるリゾホスファチジン酸誘導性小胞分泌現象の解析,
第88回日本生化学会大会, Dec. 2015.
16. 岡本 蓉子, 坪井 一人, Sonia Ara Iffat Rahman, 上田 夏生, Tamotsu Tanaka and Akira Tokumura :
新規リゾホスホリパーゼD型酵素GDE4関連代謝経路のLC-MS/MSによる同定,
第54回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2015.
17. 松田 璃沙, 坪井 一人, 岡本 蓉子, Rahman Ara Iffat Sonia, Naoshi Yamazaki, 上田 夏生, Tamotsu Tanaka and Akira Tokumura :
消化管上皮細胞に存在する新規膜結合型リゾホスホリパーゼD,
第54回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2015.
18. Tamotsu Tanaka, 伊藤 葵, 木村 朱里, 松岡 久嗣, 藤原 美奈, 喜田 孝史, Afroz Sheuli, 今井 博之 and Akira Tokumura :
植物に見出されたグリコシルイノシトールホスホセラミド特異的ホスホリパーゼDの性質,
第28回植物脂質シンポジウム, Sep. 2015.
19. 清水 良多, 魚住 幸加, 森戸 克弥, 大隅 隆, Akira Tokumura and Tamotsu Tanaka :
脂肪酸の鎖長伸長と短縮反応におけるペルオキシソームの役割,
日本脂質栄養学会第24回大会, Aug. 2015.
20. 木村 朱里, 伊藤 葵, 喜田 孝史, 松岡 久嗣, Akira Tokumura and Tamotsu Tanaka :
野菜に含まれるフィトセラミド-1-リン酸の分布と消化,
日本脂質栄養学会第24回大会, Aug. 2015.
21. Tamotsu Tanaka, 藤川 昂樹, 森戸 克弥, 清蔭 恵美, Kazunori Toida, Taro Shimizu, Tatsuhiro Ishida and Akira Tokumura :
リゾホスファチジン酸が誘導する小胞分泌現象の解析,
第57回日本脂質生化学会, May 2015.
22. 藤川 昂樹, 森戸 克弥, 生駒 照, 清蔭 恵美, Kazunori Toida, Taro Shimizu, Tatsuhiro Ishida, Akira Tokumura and Tamotsu Tanaka :
ヒト胃由来培養細胞におけるリゾホスファチジン酸誘導性小胞分泌現象の解析,
日本膜学会第37年会, May 2015.
23. 生駒 照, 屋宜 亜耶乃, 藤川 昂樹, 森戸 克弥, 南 利夫, Akira Tokumura and Tamotsu Tanaka :
穀物におけるホスファチジン酸(PA)含量とPAの抗消化性潰瘍効果,
日本薬学会第135年会, Mar. 2015.
24. 伊藤 葵, 木村 朱里, 松岡 久嗣, 藤原 美奈, 喜田 孝史, 今井 博之, Akira Tokumura and Tamotsu Tanaka :
グリコシルイノシトールホスホセラミド特異的ホスホリパーゼDの性状と分布,
日本薬学会第135年会, Mar. 2015.
25. 田畑 優美香, 山下 量平, 伊賀 永里奈, 喜田 孝史, 安藤 千恵, Akira Tokumura and Tamotsu Tanaka :
種々のセラミド-1-リン酸の生理活性,
第53回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, プログラム, 221, Nov. 2014.
26. 橋村 慧, 松田 璃沙, Yuji Inagaki, 松井 寛和, 横田 美帆, Tamotsu Tanaka, Jun-ichi Kido, Toshihiko Nagata and Akira Tokumura :
歯周病におけるリゾホスファチジン酸の役割,
第53回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, プログラム, 220, Nov. 2014.
27. 松岡 久嗣, 伊藤 葵, 木村 朱里, 藤原 美奈, 喜田 孝史, 今井 博之, Akira Tokumura and Tamotsu Tanaka :
グルコシルイノシトールホスホセラミド特異的ホスホリパーゼDの性状と分布,
第53回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, プログラム, 220, Nov. 2014.
28. 魚住 幸加, 森戸 克弥, 大隅 隆, Akira Tokumura and Tamotsu Tanaka :
脂肪酸リモデリング反応におけるペルオキシソームの役割,
第53回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, プログラム, 119, Nov. 2014.
29. 橋村 慧, 松田 璃沙, Yuji Inagaki, 松井 寛和, 横田 美帆, Tamotsu Tanaka, Jun-ichi Kido, Toshihiko Nagata and Akira Tokumura :
大豆由来リゾホスファチジン酸の歯周病抑制効果,
日本農芸化学会中四国支部第 40回講演会, 講演要旨集, 55, Sep. 2014.
30. 魚住 幸加, 森戸 克弥, 大隅 隆, Akira Tokumura and Tamotsu Tanaka :
裸子植物に含まれるポリメチレン中断型不飽和脂肪酸の動物細胞における必須脂肪酸への変換,
日本農芸化学会中四国支部第 40回講演会, 講演要旨集, 55, Sep. 2014.
31. 橋村 慧, 松田 璃沙, Yuji Inagaki, 松井 寛和, 横田 美帆, Tamotsu Tanaka, Jun-ichi Kido, Toshihiko Nagata and Akira Tokumura :
歯周病の進行に及ぼす口腔内リゾホスファチジン酸の抑制効果,
第56回 日本脂質生化学会, 講演要旨集, 146, Jun. 2014.
32. Tamotsu Tanaka, 生駒 照, 森戸 克弥, Akira Tokumura and 南 利夫 :
ホスファチジン酸(PA)の抗消化性潰瘍効果と穀類におけるPA含量,
日本農芸化学会中四国支部第 38回講演会, 講演要旨集, 24, Jan. 2014.
33. 小原 真純, Eijiro Sakamoto, Tamotsu Tanaka, Jun-ichi Kido, Toshihiko Nagata and Akira Tokumura :
骨髄幹細胞から骨芽細胞への分化におけるリゾホスファチジン酸およびその産生酵素の役割,
第52回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, プログラム, Oct. 2013.
34. 畠中 貴代子, 山下 修司, 橋村 慧, 加藤 瞭典, Tamotsu Tanaka, 中山 泰介, Hajime Kinoshita, 原 知也, Takeshi Soeki, Masataka Sata, Tetsuya Kitagawa and Akira Tokumura :
心血管病変患者血漿でのリン脂質メディエーターLC-MS/MS 分析—バイオマーカーとしての有用性—,
第52回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, プログラム, Oct. 2013.
35. 小原 真純, 坂本 英次郎, Tamotsu Tanaka, Jun-ichi Kido, Toshihiko Nagata and Akira Tokumura :
骨髄幹細胞から骨芽細胞への分化におけるリゾホスファチジン酸およびその産生酵素の役割,
第52回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, プログラム, Oct. 2013.
36. 山本 藍美, 田中 優, 山川 祥悟, Akira Kuwahara, Tamotsu Tanaka, Minoru Irahara and Akira Tokumura :
ラット卵胞発育および排卵調節機構におけるリゾホスファチジン酸受容体と代謝酵素の関与,
第52回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, プログラム, Oct. 2013.
37. 喜田 孝史, 盛重 純一, 山下 量平, 松岡 久嗣, 魚住 幸加, 里内 清, 長野 稔, 吉村 好之, Tamotsu Tanaka and Akira Tokumura :
キャベツ葉に見出されたフィトセラミド-1-リン酸の生合成経路,
第85回 日本生化学会大会, 86, Dec. 2012.
38. 山下 量平, 安藤 千恵, 田畑 優美香, 喜田 孝史, 清水 嘉文, 西迫 寛隆, 川添 和義, Tamotsu Tanaka and Akira Tokumura :
種々のセラミド-1-リン酸分子種の細胞遊走および抗アポトーシス活性,
第85回 日本生化学会大会, 86, Dec. 2012.
39. 喜田 孝史, 盛重 純一, 山下 量平, 松岡 久嗣, 魚住 幸加, 里内 清, 長野 稔, 吉村 好之, Tamotsu Tanaka and Akira Tokumura :
キャベツ葉に見出されたグリコシルイノシトールホスホセラミド-ホスホリパーゼD,
第25回 植物脂質シンポジウム, 86, Dec. 2012.
40. Ken Ishido, Yumi Kondoh, Satoru Hashimura, Akira Tokumura, Naoshi Yamazaki and Yoshiharu Takiguchi :
ラット血管肥厚形成への内因性リゾホスファチジン酸の関与,
第122回日本薬理学会近畿部会, Nov. 2012.
41. Tamotsu Tanaka, 森戸 克弥, 木下 正文, 大本 真弓, 近藤 宏樹, 瓜倉 真衣, 里内 清 and Akira Tokumura :
ホスファチジン酸によるアスピリン潰瘍抑制,
第21回 日本脂質栄養学会, Vol.21, No.2, 186, Sep. 2012.
42. Tamotsu Tanaka, 森戸 克弥, 木下 正文, 大本 真弓, 近藤 宏樹, 瓜倉 真衣, 里内 清 and Akira Tokumura :
ホスファチジン酸およびリゾホスファチジン酸によるアスピリン潰瘍抑制,
第65回 日本酸化ストレス学会学術集会, p93, Jun. 2012.
43. 清水 嘉文, 小泉 恵子, 神奈木 玲児, 田中 広治, 山下 純, Tamotsu Tanaka, 曹 科, 鈴木 元, 村手 隆, 岩城 壮一郎, 藤井 聡 and Akira Tokumura :
ヒト大腸がん細胞における低酸素条件下でのリゾリン脂質およびエーテル型リン脂質の増加,
第54回 日本脂質生化学会, 262, Jun. 2012.
44. 森戸 克弥, 木下 正文, 大本 真弓, 近藤 宏樹, 瓜倉 真衣, 里内 清, Tamotsu Tanaka and Akira Tokumura :
ホスファチジン酸によるアスピリン潰瘍抑制,
日本農芸化学会2012年度大会, プログラム, p83, Mar. 2012.
45. 石戸 健, 中本 淳子, 淺木 千佳, Akira Tokumura, Naoshi Yamazaki and Yoshiharu Takiguchi :
リゾフォスファチジン酸の血管肥厚形成への関与,
第85回日本薬理学会年会, Mar. 2012.
46. 池松 夏紀, 坪井 一人, 井上 愛美, 清水 嘉文, 宇山 徹, Tamotsu Tanaka, 上田 夏生 and Akira Tokumura :
マウス全脳におけるエタノールアミン含有脂質の分子種分析と関連酵素の基質特異性解析,
第50回 日本薬学会日本薬剤師会日本病院薬剤師会中国四国支部学術大会, Nov. 2011.
47. 淺木 千佳, 佐野 真純, Tamotsu Tanaka and Akira Tokumura :
循環血液中での血小板活性化因子(PAF)様酸化リン脂質の生成に及ぼす喫煙の影響,
第50回 日本薬学会日本薬剤師会日本病院薬剤師会中国四国支部学術大会, プログラム, p170, Nov. 2011.
48. 荷川取 史妃, 藤近 加奈子, 福田 彩, 閨 真梨子, Tamotsu Tanaka and Akira Tokumura :
種々の動物体液中のオートタキシンによるリゾホスホリパーゼD活性とタンパク量の比較,
第50回 日本薬学会日本薬剤師会日本病院薬剤師会中国四国支部学術大会, プログラム, p170, Nov. 2011.
49. 閨 真梨子, 池松 夏紀, Tamotsu Tanaka, 安田 勝彦, 神崎 秀陽 and Akira Tokumura :
血漿リゾホスホリパーゼDによるリゾホスファチジン酸産生の妊娠に伴う変動,
第50回 日本薬学会日本薬剤師会日本病院薬剤師会中国四国支部学術大会, プログラム, p169, Nov. 2011.
50. 安藤 千恵, 喜田 孝史, 山下 量平, 盛重 純一, 里内 清, 西迫 寛隆, Kazuyoshi Kawazoe, Tamotsu Tanaka and Akira Tokumura :
キャベツ葉中に見出されたフィトセラミド-1-リン酸の生物活性,
第50回 日本薬学会日本薬剤師会日本病院薬剤師会中国四国支部学術大会, プログラム, 169, Nov. 2011.
51. 中本 淳子, 板東 由佳, 淺木 千佳, Akira Tokumura, Naoshi Yamazaki and Yoshiharu Takiguchi :
ラット血管肥厚形成への内因性リゾホスファチジン酸の関与,
第50回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Nov. 2011.
52. 清水 嘉文, 森川 美幸, 木元 重信, Tamotsu Tanaka and Akira Tokumura :
アトピー性皮膚炎発症マウスの血液中および皮膚炎発症部で高値となるリゾホスファチジン酸の病態生理学的役割,
第84回 日本生化学会大会, プログラム号, p103, Sep. 2011.
53. Tamotsu Tanaka, 喜田 孝史, 盛重 純一, 安藤 千恵, 山下 量平, 里内 清, 今井 博之, 長野 稔, 西迫 寛隆, 川添 和義 and Akira Tokumura :
キャベツ葉中に見出されたフィトセラミド-1-リン酸の生合成経路と生理作用,
第84回 日本生化学会大会, プログラム号, p90, Sep. 2011.
54. Tamotsu Tanaka, 葛西 彩香, 木下 正文, 森戸 克弥, 大 本真弓, 近藤 宏樹, 瓜倉 真衣, 盛重 純一, 里内 清 and Akira Tokumura :
種々の食材のホスファチジン酸含量と胃における消化,
日本脂質栄養学第20回大会 脂質栄養学, Vol.20, No.2, 143, Sep. 2011.
55. 喜田 孝史, 盛重 純一, 安藤 千恵, 里内 清, 今井 博之, 長野 稔, Tamotsu Tanaka and Akira Tokumura :
キャベツ葉中に見出されたフィトセラミド-1-リン酸,
第52回 日本生化学会 中国・四国支部例会, 講演要旨集,, p76, May 2011.
56. 清水 嘉文, 足立 美佳, 森川 美幸, 木元 重信, Tamotsu Tanaka and Akira Tokumura :
アトピー性皮膚炎の新規掻痒因子としてのリゾホスファチジン酸の可能性,
第53回 日本脂質生化学会, 講演要旨集, p110, May 2011.
57. 猪野 真基, 大園 翔平, 清水 嘉文, 井上 愛美, Tamotsu Tanaka and Akira Tokumura :
生理活性リン脂質リゾホスファチジン酸のラット血漿における産生および分解に及ぼす副腎摘出の効果,
日本薬学会第131年会,プログラム, 169, Mar. 2011.
58. 盛重 純一, 瓜倉 真衣, 葛西 彩香, Tamotsu Tanaka, Akira Tokumura, 小池 透 and 里内 清 :
リン酸捕獲試薬を用いた簡易リゾホスファチジン酸分析法の食品への適用,
日本農芸化学会中四国支部第29回講演会, Jan. 2011.
59. 葛西 彩香, 木下 正文, 足立 美佳, 盛重 純一, 瓜倉 真衣, 里内 清, Yoshiki Kashiwada, 今林 潔, Yoshihisa Takaishi, Tamotsu Tanaka and Akira Tokumura :
種々の食材中の創傷治癒性リン脂質含量,
日本農芸化学会中国四国支部第29回講演会,講演要旨集, 28, Jan. 2011.
60. 木下 正文, 足立 美佳, 葛西 彩香, 大本 真弓, Tamotsu Tanaka, 盛重 純一, 瓜倉 真衣, 近藤 宏樹, 里内 清 and Akira Tokumura :
メディエーターリン脂質による抗消化性潰瘍効果,
日本農芸化学会中国四国支部第29回講演会,講演要旨集, 28, Jan. 2011.
61. 盛重 純一, 瓜倉 真衣, 葛西 彩香, Tamotsu Tanaka, Akira Tokumura, 小池 透 and 里内 清 :
リン脂質捕獲試薬を用いた簡易リゾホスファチジン酸分析法の食品への適用,
日本農芸化学会中国四国支部第29回講演会,講演要旨集, 28, 2011.
62. 盛重 純一, 上田 香織, 中尾 充泰, 佐野 茂樹, 里内 清 and Akira Tokumura :
卵白リゾホスホリパーゼDにより産生されるリゾホスファチジン酸の卵黄嚢の血管形成作用,
Dec. 2010.
63. 三木 敏史, 清水 嘉文, 井上 友希子, Tamotsu Tanaka and Akira Tokumura :
Mass spectrometric analysis of dicarboxylate semialdehyde-containing lysophosphatidylcholine produced during peroxidation of lysophosphatidylcholine by lipoxygenase,
第33回日本分子生物学会・第83会日本生化学会合同大会,プログラム, 317, Dec. 2010.
64. 片山 貴大, 西本 真梨子, 清水 嘉文, 稲葉 真衣子, Tamotsu Tanaka and Akira Tokumura :
Exposure to the surface of cultured vascular smooth muscle cells of lysophospholipid and their extracellular release,
第33回日本分子生物学会・第83会日本生化学会合同大会,プログラム, 317, Dec. 2010.
65. Tamotsu Tanaka, 盛重 純一, 喜田 孝史, 安藤 千恵, 木下 正文, 葛西 彩香, 大本 真弓, 瓜倉 真衣, 里内 清 and Akira Tokumura :
キャベツ葉中に見出されたフィトセラミド-1-リン酸,
第33回日本分子生物学会・第83回日本生化学会大会合同大会,プログラム, 315, Dec. 2010.
66. 山本 淳平, 山里 将士, 桑原 絵美, 清水 嘉文, 朝治 広貴, Tamotsu Tanaka, Akira Kuwahara and Akira Tokumura :
不妊治療患者の卵胞液におけるオートタキシンによる生理活性リゾリン脂質の産生,
第49回日本薬学会・薬剤師会・日本病院薬剤師会 中国四国支部学術大会,講演要旨集, 126, Nov. 2010.
67. Akira Tokumura, Yamamoto Junpei, YAmazato Mssashi, Nikawadori Miki, Shimizu Yoshinobu and Tamotsu Tanaka :
Preferable production of lysophosphatidic acids having a polyunsaturated fatty acyl group by lysophospholipase D activity of autotaxin in fresh follicular fluid from patients programmed with in vitro fertilization.,
Sep. 2010.
68. Tamotsu Tanaka, 盛重 純一, 喜田 孝史, 安藤 千恵, 木下 正文, 葛西 彩香, 大本 真弓, 瓜倉 真衣, 里内 清 and Akira Tokumura :
キャベツ葉に見出されたフィトセラミド-1-リン酸,
第28回 日本農芸化学会中四国支部講演会 講演要旨集, 65, Sep. 2010.
69. 瓜倉 真衣, 盛重 純一, 森 一弘, 横川 和弘, 葛西 彩香, Tamotsu Tanaka, Akira Tokumura and 里内 清 :
抗潰瘍作用を目的とするホスホリパーゼD活性の高い野菜の有効な摂取法,
日本脂質栄養学会 第19回大会,脂質栄養学, Vol.19, 194, Sep. 2010.
70. 盛重 純一, 里内 清 and Akira Tokumura :
卵白リゾホスホリパーゼDにより産生されるリゾホスファチジン酸の卵黄嚢の血管形成作用,
Jun. 2010.
71. Tamotsu Tanaka, 盛重 純一, 喜田 孝史, 安藤 千恵, 木下 正文, 葛西 彩香, 大本 真弓, 瓜倉 真衣, 里内 清 and Akira Tokumura :
キャベツ葉中に見出されたフィトセラミド-1-リン酸,
第52回日本脂質生化学会,講演要旨集, 77, Jun. 2010.
72. 片山 貴大, 西本 真梨子, 清水 嘉文, 稲葉 真衣子, Tamotsu Tanaka and Akira Tokumura :
リゾリン脂質メディエーターのラット大動脈血管平滑筋細胞表面への露出と細胞外への遊離,
日本薬学会第130年会,講演要旨集3, 121, Mar. 2010.
73. 三木 敏史, 清水 嘉文, 井上 友希子, Tamotsu Tanaka and Akira Tokumura :
多価不飽和脂肪酸含有リゾホスファチジルコリンのリポキシゲナーゼ誘導過酸化反応に伴い生成する二次成績体の構造解析,
日本薬学会第130年会 講演要旨集3, 121, Mar. 2010.
74. 三木 敏史, 清水 嘉文, 井上 友希子, Tamotsu Tanaka and Akira Tokumura :
多価不飽和脂肪酸含有ホスファチジルコリンのリポキシゲナーゼ誘導過酸化反応に伴い生成する二次成績体の構造解析,
日本薬学会第130年会,講演要旨集3, 121, Mar. 2010.
75. 木下 正文, 近藤 宏樹, 足立 美佳, 瓜倉 真衣, 盛重 純一, 里内 清, Tamotsu Tanaka and Akira Tokumura :
キャベツの摂取によって胃の中で生じる創傷治癒因子としてのリゾホスファチジン酸,
日本薬学会第130年会 講演要旨集3, 85, Mar. 2010.
76. 近藤 宏樹, 瓜倉 真衣, 木下 正文, 足立 美佳, 盛重 純一, Akira Tokumura, Tamotsu Tanaka and 里内 清 :
消化管で生じるリゾホスファチジン酸の胃粘膜への作用,
日本農芸化学会中四国支部第26回講演会, 36, Jan. 2010.
77. 足立 美佳, 盛重 純一, Tamotsu Tanaka, Junji Terao, 里内 清 and Akira Tokumura :
食品素材や漢方薬に含まれるリゾホスファチジン酸のラットストレス性胃潰瘍に対する抑制作用,
第48回日本薬学会/日本薬剤師会/日本病院薬剤師会中国四国支部学術大会, Nov. 2009.
78. 猪野 真基, 大園 翔平, 清水 嘉文, 上田 香織, Tamotsu Tanaka and Akira Tokumura :
ラット血漿におけるリゾホスホリパーゼDによる生理活性リン脂質LPA産生に及ぼす副腎摘出の影響,
第48回日本薬学会/日本薬剤師会/日本病院薬剤師会中国四国支部学術大会, Nov. 2009.
79. Akira Tokumura, 上田 香織, 足立 美香, 竹永 葉月, 盛重 淳一, 堤 敏彦 and Yoshiharu Takiguchi :
哺乳類体液におけるリゾホスファチジン酸レベルの調節機構ーシンポジウム「生理活性リゾリン脂質研究Update」,
第82回日本生化学会大会, Oct. 2009.
80. 足立 美佳, 盛重 純一, Tamotsu Tanaka, Junji Terao, 里内 清 and Akira Tokumura :
水浸拘束ストレス負荷によるラット胃潰瘍形成に及ぼす食物やリゾホスファチジン酸の抑制効果,
第82回日本生化学会大会, Oct. 2009.
81. Tamotsu Tanaka, 近藤 宏樹, 木下 正文, 足立 美佳, 瓜倉 真衣, 盛重 純一, 里内 清 and Akira Tokumura :
野菜の消化で生じるリゾホスファチジン酸,
日本脂質栄養学会第18回大会, Vol.18, 180, Sep. 2009.
82. 片山 貴大, 西本 真梨子, 清水 嘉文, 稲葉 麻衣子, Tamotsu Tanaka and Akira Tokumura :
リゾリン脂質メディエーターのラット大動脈血管平滑筋細胞表面への露出と細胞外への遊離,
日本薬学会第130年会, 3-121, Mar. 2009.
83. 三木 敏史, 清水 嘉文, 井上 友希子, Tamotsu Tanaka and Akira Tokumura :
多価不飽和脂肪酸含有リゾホスファチジルコリンのリポキシゲナーゼ誘導か参加反応に伴い生成する二次成績体の構造解析,
日本薬学会第130年会, 3-121, Mar. 2009.
84. 木下 正文, 近藤 宏樹, 足立 美佳, 瓜倉 真衣, 盛重 純一, 里内 清, Tamotsu Tanaka and Akira Tokumura :
キャベツの摂取によって胃の中で生じる創傷治癒因子としてのリゾホスファチジン酸,
日本薬学会第130年会, 3-85, Mar. 2009.
85. Tamotsu Tanaka, 近藤 宏樹, 新宅 友則, 木下 正文, 盛重 純一, 里内 清 and Akira Tokumura :
食品の消化で生じるリゾホスファチジン酸による消化管組織修復,
日本農芸化学会2009年度大会 講演要旨集, 202, Mar. 2009.
86. 梶 真一朗, 竹永 葉月, Naoshi Yamazaki, Akira Tokumura and Yoshiharu Takiguchi :
The effect of lysophosphatidic acid on myocardial ischemia-reperfusion injury,
第82回 日本薬理学会年会, Mar. 2009.
87. Akira Tokumura, 足立 美佳, 稲葉 真衣子, 室田 佳恵子, Tamotsu Tanaka and 寺尾 純二 :
消化器系の管腔側から作用するリゾリン脂質の生理的および病態生理的役割,
第31回日本分子生物学会・第81回日本生化学会大会 合同大会 講演要旨集, 175, Dec. 2008.
88. 竹永 葉月, 梶真 一朗, 松田 彩佳, Akira Tokumura and Yoshiharu Takiguchi :
心筋虚血再灌流障害における脂質メディエーターリゾホスファチジン酸の生理的役割,
第47回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, Nov. 2008.
89. Tamotsu Tanaka, 堀内 剛, 近藤 宏樹, 松岡 恵, 盛重 純一, 平野 薫, 里内 清, Akira Tokumura and 小池 透 :
キャベツの消化プロセスで生じる創傷治癒ホルモン・リゾホスファチジン酸による消化管組織修復,
日本農芸化学会2008年度中四国支部大会 講演要旨集, 40, Sep. 2008.
90. 里内 清, Tamotsu Tanaka and Akira Tokumura :
Protection of gastric mucous membrane by lysophosphayidic acid in foodstuffs,
脂質生化学会研究, Vol.50, p12, Jun. 2008.
91. Toshihiko Tsutsumi, Mika Adachi and Akira Tokumura :
Metabolism and internalization of lysophosphatidylcholine in kidney epithelial cells,
第80回日本生化学会, Dec. 2007.
92. 唐沢 健, 渋谷 恵理, 御厨 理沙子, 原田 史子, 佐藤 典子, 横山 和明, 菊地 真樹, 盛重 純一, Akira Tokumura and 井上 圭三 :
刺激ヒト赤血球において産生される血小板活性化因子(PAF)および関連脂質の解析,
第80回日本生化学会, Dec. 2007.
93. 遠藤 智子, 濱 弘太郎, 金井 求, 松木 則夫, 柴崎 正勝, Akira Tokumura, Chun Jerold, 新井 洋由 and 青木 淳賢 :
リゾホスファチジン酸受容体LPA3の新規生理機能の探索,
第80回日本生化学会, Dec. 2007.
94. 盛重 純一, Yasuko Yoshioka, Hitoshi Hori and Akira Tokumura :
ニワトリ初期胚の血管系形成における卵白リゾホスファチジン酸の生理的役割,
第80回日本生化学会, Dec. 2007.
95. Akira Tokumura, 稲葉 真衣子, 平良 智 and 盛重 純一 :
リゾホスホリパーゼDにより産生するリゾホスファチジン酸の細胞膜分布と移行,
第80回日本生化学会, Dec. 2007.
96. 田中 保, 堀内 剛, 平野 薫, 菊田 安至, 里内 清, Akira Tokumura, 盛重 純一, Mandi Murph, Gordon Mills and 小池 透 :
食品に含まれる創傷治癒ホルモン·リゾホスファチジン酸,
日本脂質栄養学会第16回大会, Aug. 2007.
97. 佐野 真純, Akira Tokumura, Koichiro Tsuchiya, Akira Shibata and Kenji Fukuzawa :
過酸化脂質の簡易比色定量法:発色成分 [キシレノールオレンジFe3+錯体ー膜ホスファチジルコリン] 複合体の性質,
日本過酸化脂質フリーラジカル学会第31回大会, Jun. 2007.
98. 盛重 純一, 稲葉 真衣子, 落合 美緒, Yasuko Yoshioka, Kenji Fukuzawa and Akira Tokumura :
マウス繊維芽細胞のリゾホスホリパーゼDによるリゾホスファチジン酸産生,
第49回日本脂質生化学会, Jun. 2007.
99. Akira Tokumura :
細胞外でリゾ脂質メディエーターを産生するリゾホスホリパーゼCとD,
第49回日本脂質生化学会, Jun. 2007.
100. 田中 保, 堀内 剛, 平野 薫, Akira Tokumura, 盛重 純一, 小池 透, Mandi Murph, Gordon Mills and 里内 清 :
消化プロセスで生じる創傷治癒ホルモンリゾホスファチジン酸による消化管組織修復,
第48回日本脂質生化学会中国四国支部大会, May 2007.
101. 頼光 翔, 黒川 ふみ, 池江 克文, Shigeki Sano, Akira Tokumura and Kenji Fukuzawa :
脂質酸化二次産物による血管内皮細胞障害およびビタミンEによる防御作用,
日本ビタミン学会第59回大会, May 2007.
102. 渋谷 恵理, 唐沢 健, 原田 史子, 佐藤 典子, 横山 和明, 菊池 真樹, 盛重 純一, Akira Tokumura and 井上 圭三 :
ヒト赤血球膜における血小板活性化因子(PAF)産生とPAF代謝酵素の解析,
日本薬学会第127年会, Mar. 2007.
103. 桑原 絵美, Shuji Yamano, 盛重 純一, Akira Tokumura and Kenji Fukuzawa :
リゾホスファチジン酸によるマウス卵丘細胞からのヒアルロン酸遊離と卵丘膨化,
日本薬学会第127年会, Mar. 2007.
104. Akira Tokumura, 吉原 添修, 盛重 純一 and Kenji Fukuzawa :
ヒト口腔粘膜細胞のエクト型リゾホスホリパーゼDによるリン脂質性増殖因子(LPA)の産生,
日本薬学会第127年会, Mar. 2007.
105. Yasuko Yoshioka, 盛重 純一, 稲葉 真衣子, 菊地 真樹 and Akira Tokumura :
リゾリン脂質メディエーターのLC/MS/MSによる分子種分析,
質量分析総合討論会, No.55, 426-427, 2007.
106. 佐野 真純, 道倉 亜美, Akira Tokumura, Akira Shibata and Kenji Fukuzawa :
キシレノールオレンジ錯体形成によるFe2+定量法の開発と過酸化物簡易定量法への応用,
第45回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Oct. 2006.
107. 吉原 添修, 盛重 純一, Akira Tokumura and Kenji Fukuzawa :
リゾリン脂質メディエーター産生酵素の阻害物質の探索とその検定法の構築,
第45回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Oct. 2006.
108. Kenji Fukuzawa, 佐野 真純, 道倉 亜美, Akira Shibata and Akira Tokumura :
改良FOX法による過酸化脂質の簡易定量,
日本過酸化脂質フリーラジカル学会第30回大会, Oct. 2006.
109. 盛重 純一, Hideko Nagasawa, Hitoshi Hori, Kenji Fukuzawa and Akira Tokumura :
ニワトリ卵白のリゾホスホリパーゼDによるリゾホスファチジン酸の産生,
第48回日本脂質生化学会, Jun. 2006.
110. Akira Tokumura, 平良 智, Kenji Fukuzawa, 堤 敏彦, 北山 友也 and 森田 克也 :
ヒト口腔粘膜細胞のエクト型リゾホスホリパーゼDによるリン脂質性増殖因子(LPA)の産生,
日本薬学会第126年会, Mar. 2006.
111. Akira Tokumura, Toshihiko Tsutsumi, Satoshi Taira, Kenji Fukuzawa and Mitchel Watsky :
Lysophospholipase D and elevates lysophosphatidylcholine as sources of elevated aqueous humor LPA following rabbit corneal injury,
第78回日本生化学会, Oct. 2005.
112. Toshihiko Tsutsumi and Akira Tokumura :
METABOLISM AND INTERNALIZATION OF LYSOPAF IN KIDNEY EPITHELIAL CELLS,
第78回日本生化学会, Oct. 2005.
113. J. Morishige, T. Tanaka, K. Satouchi, Akira Tokumura and Kenji Fukuzawa :
Production of lysophosphatidic acid by lysophospholipase D in hen egg white,
第78回日本生化学会, Oct. 2005.
114. Akira Tokumura, Toshihiko Tsutsumi, Satoshi Taira, Kenji Fukuzawa and Michel Watsky :
Lysophospholipase D and elevates lysophosphatidylcholine as sources of elevated aqueous humor LPA following rabbit corneal injury,
第78回日本生化学会, Oct. 2005.
115. 土屋 浩一郎, 赤井 かおり, Akira Tokumura, 玉置 俊晃 and Kenji Fukuzawa :
発癌性鉄錯体Fe3+-ニトリロ三酢酸(Fe3+-NTA)による光依存活性酸素生成機序の検討,
第27回日本フリーラジカル学会, Jun. 2005.
116. Akira Tokumura, 堤 敏彦, 福田 彩, 初山 和光, Kenji Fukuzawa and M. Watsk :
ウサギ房水のリゾホスホリパーゼ活性によるリゾリン脂質の分解,
第47回日本脂質生化学会, Jun. 2005.
117. Kenji Fukuzawa, 真鍋 幸恵, Kentaro Kogure and Akira Tokumura :
マウスに移植した黒色腫瘍に対するα-トコフェロール誘導体の抗ガン効果,
日本ビタミン学会大会, Vol.57, May 2005.
118. Kenji Fukuzawa, 赤井 かおり, Akira Tokumura, 土屋 浩一郎 and 柴田 瑩 :
腎癌誘発鉄錯体Fe-ニトリロ三酢酸(Fe3+-NTA)の脂質過酸化誘導活性,
日本過酸化脂質フリーラジカル学会28回大会, Oct. 2004.
119. 平良 智, Akira Tokumura, Kenji Fukuzawa, 北山 友也, 森岡 徳光 and 土肥 敏博 :
口腔リゾホスホリパーゼDによるリゾホスファチジン酸の産出,
第46回歯科基礎医学会学術大会, Sep. 2004.
120. Akira Tokumura, 蔭山 千恵子, Kenji Fukuzawa, 北山 友也, 森田 克也 and 土肥 敏博 :
腔でのリゾリン脂質メデイエーター産出-リゾホスホリパーゼ D の関与-,
第46回歯科基礎医学会学術大会, Sep. 2004.
121. Akira Tokumura, 藤近 加奈子, 蔭山 千恵子, 檜尾 健二, 苛原 稔 and Kenji Fukuzawa :
動物体液中でリゾリン脂質リン酸メデイエーターを産出するリゾホスホリパーゼD活性の比較,
日本薬学会年会, Vol.124, Mar. 2004.
122. 藤近 加奈子, 蔭山 千恵子, Akira Tokumura and Kenji Fukuzawa :
種々の動物体液に存在するリゾホスホリパーゼD活性の比較,
第42回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Nov. 2003.
123. 平良 智, 蔭山 千恵子, Akira Tokumura and Kenji Fukuzawa :
ヒト混合唾液リゾホスホリパーゼDによる生理活性リン脂質LPAの産出,
第42回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Nov. 2003.
124. 初山 和光, 富永 恭子, Akira Tokumura and Kenji Fukuzawa :
モルモット腹腔洗浄液中に存在するリゾホスホリパーゼDの基質特異性,
第42回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Nov. 2003.
125. Kenji Fukuzawa, 赤井 かおり, 土屋 浩一郎, Kentaro Kogure, Akira Tokumura and 玉置 俊晃 :
配位構造の異なる3つのタイプのFe-NTA錯体による脂質過酸化の誘導,
日本過酸化脂質フリーラジカル学会27回大会, Oct. 2003.
126. Chieko Kageyama, Akira Tokumura, Tamotsu Tanaka, Junichi Morishige, Kiyoshi Satouchi and Kenji Fukuzawa :
Secretion of lysophospholipase D activity from Swiss 3T3 fibroblasts,
第76回日本生化学会大会, Oct. 2003.
127. Akira Tokumura, 藤近 加奈子 and Kenji Fukuzawa :
ニワトリ卵白のリゾホスホリパーゼDによる生理活性リン脂質の産出,
平成15年度日本農芸化学会西日本支部,中四国支部,日本栄養・食糧学会西日本支部,日本食品科学工学会西日本支部鹿児島合同大会, Sep. 2003.
128. 赤井 かおり, 土屋 浩一郎, Kentaro Kogure, Akira Tokumura, 玉置 俊晃 and Kenji Fukuzawa :
発癌性鉄錯体Fe3+-ニトリロ三酢酸(Fe3+-NTA)の光およびphに依存した活性酵素の産出と脂質過酸化の誘導,
第25回日本フリーラジカル学会, Jun. 2003.
129. Akira Tokumura, 平尾 恵理, 丸山 佑史, Kentaro Kogure and Kenji Fukuzawa :
正常および異常妊娠時のヒト血清リゾホスホリパーゼD活性,
第45回日本脂質生化学会, Jun. 2003.
130. 真鍋 幸恵, Kentaro Kogure, 浜 進, 森田 健之, Akira Tokumura and Kenji Fukuzawa :
ビタミンEコハク酸のガン細胞におけるアポトーシス誘導作用へのH2O2の関与,
日本ビタミン学会55回大会, May 2003.
131. 蔭山 千恵子, Akira Tokumura, Kentaro Kogure, Kenji Fukuzawa and 土肥 敏博 :
ヒト唾液に存在するリゾホスホファチジン酸産生酵素リゾホスホリパーゼDの症状,
日本薬学会年会, Vol.123, Mar. 2003.
132. Akira Tokumura, 平尾 恵理, 丸山 佑史, Kentaro Kogure, 安田 勝彦, 神崎 秀陽 and Kenji Fukuzawa :
異常妊娠婦人の血清リゾホスホリパーゼD活性:正常妊娠婦人との価との比較,
日本薬学会年会, Vol.123, Mar. 2003.
133. Kentaro Kogure, 濱 進, Satoru GOTO, Akira Tokumura and Kenji Fukuzawa :
Vitamin Eコハク酸はPKCを直接活性化する,
日本薬学会第123年会, Mar. 2003.
134. 齋藤 恭章, 赤井 かおり, Kentaro Kogure, Akira Tokumura, 柴田 瑩 and Kenji Fukuzawa :
血清アルブミンの膜脂質過酸化抑制作用,
第24回生体膜と薬物の相互作用シンポジウム, Nov. 2002.
135. 土江 明子, Akira Tokumura, Kentaro Kogure and Kenji Fukuzawa :
ヒト血液中で酸化ストレスを受け生成する短鎖ジカルボン酸含有ホスファチジルコリンの定量,
第41回日本薬学会・日本病院薬剤師会中国四国支部学術大会, Nov. 2002.
136. Kentaro Kogure, 森田 健之, Akira Tokumura and Kenji Fukuzawa :
トコフェロールコハク酸のアポトーシス誘導作用と細胞の活性酸素防御能,
日本過酸化脂質フリーラジカル学会26回大会, Oct. 2002.
137. Kentaro Kogure, 木崎 真弓, Ichiro Suzuki, Akira Tokumura, 渋谷 雅之 and Kenji Fukuzawa :
アポトーシス誘導作用におけるトコフェロールコハク酸類縁体の構造活性相関の検討,
日本過酸化脂質フリーラジカル学会26回大会, Oct. 2002.
138. Akira Tokumura, 真島 英司, 刈谷 優子, 富永 恭子, Kentaro Kogure, 安田 勝彦 and Kenji Fukuzawa :
生理活性リン脂質LPAを産出する血漿リゾホスホリパーゼDの性状,
日本生化学会大会, Vol.75, Oct. 2002.
139. 中島 佐和, Kentaro Kogure, 土江 明子, Akira Tokumura and Kenji Fukuzawa :
酸化リン脂質によって誘導される血管平滑筋細胞の障害,
日本生化学会大会, Vol.75, Oct. 2002.
140. 蔭山 千恵子, Akira Tokumura, Kentaro Kogure, Kenji Fukuzawa and 土肥 敏博 :
ヒト唾液中でリゾホスファチジン酸を産出するリゾホスホリパーゼDの性質,
日本生化学会大会, Vol.75, Oct. 2002.
141. Kentaro Kogure, 浜 進, Akira Tokumura and Kenji Fukuzawa :
ビタミンEコハク酸の作用発現における細胞内シグナル機構の関与,
日本生化学会大会, Vol.75, Oct. 2002.
142. 浜 進, Kentaro Kogure, Satoru GOTO, Ichiro Suzuki, Akira Tokumura, Masayuki Shibuya and Kenji Fukuzawa :
トコフェロール-コハク酸によるPKCを介したNO産生促進機構,
第41回日本薬学会·日本病院薬剤師会中国四国支部学術大会, Oct. 2002.
143. Akira Tokumura, 富永 恭子, Kentaro Kogure, Kenji Fukuzawa, 安田 勝彦, 刈谷 優子 and 真島 英司 :
生理活性リン脂質LPAを産出するヒト血漿リゾホスホリパーゼDは多機能性ヌクレオチドホスホジエステラーゼautotaxinである,
日本脂質生化学研究会第44回研究集会, Jun. 2002.
144. 真鍋 幸恵, Kentaro Kogure, 浜 進, 中島 佐和, Akira Tokumura and Kenji Fukuzawa :
黒色腫瘍に対するα-トコフェロールコハク酸の抗ガン効果,
日本ビタミン学会大会, Vol.54, Apr. 2002.
145. 浜 進, Kentaro Kogure, 中島 佐和, 真鍋 幸恵, Akira Tokumura and Kenji Fukuzawa :
トコフェロールコハク酸によるNO産生促進効果の機構解析,
日本ビタミン学会大会, Vol.54, Apr. 2002.
146. 土江 明子, Akira Tokumura, Kentaro Kogure and Kenji Fukuzawa :
喫煙者及び非喫煙者血漿に存在する酸化ホスファチジルコリン分子種組成の比較,
日本薬学会年会, Vol.122, Mar. 2002.
147. Kentaro Kogure, 浜 進, 真鍋 幸恵, Akira Tokumura and Kenji Fukuzawa :
アポトーシス誘導作用を有するトコフェロールコハク酸の構造的因子の検討,
日本薬学会年会, Vol.122, Mar. 2002.
148. Akira Tokumura, 平畠 宏行, 岡山 朋郁, 河上 律子, Kentaro Kogure and Kenji Fukuzawa :
ホスファチジン酸による好中球O2-産出に対するホスホリパーゼA2阻害剤の作用,
日本薬学会年会, Vol.122, Mar. 2002.
149. Akira Tokumura, Yasuko Yoshioka, 住田 常喜, 東嶋 裕興 and Kenji Fukuzawa :
リポキシゲナーゼによる酸素添加反応を経て生成する酸化ホスファチジルコリンの質量分析,
質量分析総合討論会, Vol.47, 132-133, May 1999.

Et cetera, Workshop:

1. 盛重 純一, Akira Tokumura and Kenji Fukuzawa :
生体膜脂質の生理的および病態生理的役割,
日本農芸化学会中四国支部創設5周年記念特別講演会, Mar. 2007.
2. Akira Tokumura :
ニワトリ卵白のリゾリン脂質とその代謝酵素の機能,
日本農芸化学会中四国支部創設5周年記念特別講演会, Mar. 2007.
3. 吉原 添修, 盛重 純一, Akira Tokumura and Kenji Fukuzawa :
リゾリン脂質メディエーター産生酵素の阻害物質の探索とその検定法の構築,
第7回長井長義記念シンポジウム, Sep. 2006.
4. 桑原 絵美, 盛重 純一, Shuji Yamano, Akira Tokumura and Kenji Fukuzawa :
リゾホスファチジン酸によるマウス卵丘細胞からのヒアルロン酸分泌と卵丘膨化 -卵成熟および排卵促進機構への関与の可能性ー,
第7回長井長義記念シンポジウム, Sep. 2006.
5. Kenji Fukuzawa, Kentaro Kogure, 真鍋 幸恵 and Akira Tokumura :
α-トコフェロールジカルボン酸誘導体の抗ガン作用,
第17回ビタミンE研究会, Jan. 2006.
6. Akira Tokumura, 土江 明子, 平良 智, 黒川 ふみ and Kenji Fukuzawa :
喫煙による循環血液での酸化リン脂質の産出 - 血管病変への関与の可能性 -,
第21回平成17年度助成研究発表会, Jul. 2005.
7. 盛重 純一, 田中 保, 里内 清, Akira Tokumura and Kenji Fukuzawa :
ニワトリ卵白のリゾホスホリパーゼDによるリゾホスファチジン酸の産出,
第6回長井長義記念シンポジウム, Jul. 2005.
8. Akira Tokumura, 土江 明子, 平良 智 and Kenji Fukuzawa :
喫煙による循環血液での酸化リン脂質の産出 - 血管病変への関与の可能性 -,
第20回平成16年度助成研究発表会, Jul. 2005.
9. Kenji Fukuzawa, Kentaro Kogure and Akira Tokumura :
α-トコフェロール・コハク酸の酸化的アポトーシスと抗ガン作用,
第5回AOB(Antioxidant Biofactor)研究会:食品機能と酸化ストレス, Jun. 2005.
10. Kenji Fukuzawa, 真鍋 幸恵, Kentaro Kogure and Akira Tokumura :
α-トコフェロール誘導体のアポトーシス誘導作用:構造-活性相関,
第16回ビタミンE研究会, Jan. 2005.
11. Akira Tokumura, 土江 明子, 平良 智 and Kenji Fukuzawa :
喫煙による循環血液での酸化リン脂質の産出 - 血管病変への関与の可能性 -,
平成15年度助成研究発表会, Jul. 2004.
12. Kenji Fukuzawa, Kentaro Kogure, 中島 佐和, 土江 明子 and Akira Tokumura :
ビタミンEによるリン脂質酸化二次産物誘導血管平滑筋細胞アポトーシスの抑制,
第15回ビタミンE研究会, Jan. 2004.
13. Kenji Fukuzawa, 中島 佐和, 土江 明子, Kentaro Kogure and Akira Tokumura :
PAF様リン脂質酸化二次産物とビタミンE,
第300回脂溶性ビタミン総合研究委員会, Jun. 2003.
14. 真鍋 幸恵, Kentaro Kogure, 森田 健之, Akira Tokumura and Kenji Fukuzawa :
抗がん剤として製剤化を指向したビタミンEコハク酸ベクシル,
第14回ビタミンE研究会, Jan. 2003.
15. Kentaro Kogure, 浜 進, 真鍋 幸恵, Akira Tokumura and Kenji Fukuzawa :
トコフェロールコハク酸のガン細胞に対するアポトーシス誘導作用の検討,
第13回ビタミンE研究会, Jan. 2002.
16. 浜 進, Kentaro Kogure, 森田 元喜, 中島 佐和, Akira Tokumura and Kenji Fukuzawa :
α-トコフェロールコハク酸によるNO産出促進にPKCが関与する,
第13回ビタミンE研究会, Jan. 2002.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Novel mechanisms for the biosynthesis of the lipid mediator regulating appetite and obesity (Project/Area Number: 26350894 )
  • Effect of plant phospholipid on integrity of gastrointestinal mucosa (Project/Area Number: 24580185 )
  • Lysophosphatidic acid production by novel membrane-bound lysophospholipase D and protection of oral mucosa (Project/Area Number: 23590079 )
  • Studies on gastrointestinal mucosa-maintaining factors produced during digestion of foods (Project/Area Number: 21580141 )
  • Marignancy of cell-proliferative diseases by unusual production of phospholipid mediators in response to oxidative stress (Project/Area Number: 16390034 )
  • Progression of atherosclerotic lesions induced by excess production of lysophosphatidic acid, a growth factor in serum (Project/Area Number: 13672288 )
  • Investigation on the involvment of oxidized phospholipids and lysophospholipids in the pathogenesis of atherosclerosis (Project/Area Number: 10672043 )
  • Proliferation and migration of vascular smooth muscle cell induced by novel physiologically active phospholipid (Project/Area Number: 07672363 )
  • Lipid mediators in circulation and hypertension (Project/Area Number: 03671055 )
  • PAFの生合成並びに遊離に及ぼす食餌性脂質の効果 (Project/Area Number: 62560087 )
  • Search by Researcher Number (00035560)