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Tokushima UniversityGraduate School of Biomedical Sciences薬学域Pharmaceutical SciencePharmaceutical Life SciencesDepartment of Pharmacokinetics and Biopharmaceutics
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Tokushima UniversityResearch ClustersResearch Clusters2202004 次世代DDS拠点形成:従来DDSの常識を超えた薬物送達技術の開発と難治性疾患治療への展開
Tokushima UniversityGraduate School of Pharmaceutical SciencesPharmacy
Tokushima UniversityFaculty of Pharmaceutical SciencesPharmaceutical Sciences生命医療薬学講座Biopharmaceutics
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Research

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Field of Study

Biopharmaceutics

Subject of Study

Development of drug delivery system with liposomes (liposomes, drug delivery system, cancer therapy, ischemia, pharmacokinetics)

Book / Paper

Book:

1. Emam Emam Abdallah Sherif, Elhewan Emam Elsadek Emam Ali Nehal, Taro Shimizu and Tatsuhiro Ishida :
The Post-insertion Method for the Preparation of PEGylated Liposomes. in Liposomes Methods and Protocols (3rd Edition),
Springer, Feb. 2023.
2. Sherif Abdallah Emam Emam, Nehal Ali Emam Elsadek Emam Elhewan, Taro Shimizu and Tatsuhiro Ishida :
The Post-insertion Method for the Preparation of PEGylated Liposomes,
Springer, Feb. 2023.
3. Taro Shimizu and Tatsuhiro Ishida :
中分子医薬品やDDSに対する免疫応答,
CMC Publishing Co.,Ltd., Mar. 2022.
4. 田島 健次, 松島 得雄, 小瀬 亮太, 藤田 彩華, 甲野 裕之, Hidenori ANDO and Tatsuhiro Ishida :
ナノフィブリル化バクテリアセルロースの生産とその応用,
NTS Inc., Nov. 2021.
5. Taro Shimizu and Tatsuhiro Ishida :
タンパクやナノ粒子に対するPEG修飾の有用性と免疫系に与える影響,
Technical Information Institute Co., Ltd., Aug. 2021.
6. Elhewan Emam Elsadek Emam Ali Nehal, Lila Selim Ahmed Ali Abu Amr and Tatsuhiro Ishida :
Immunogenicity against PEGylated proteins, in Polymer-protein conjugates: From PEGylation and beyond (Chapter 5),
Elsevier Inc., Nov. 2019.
7. 田島 健次, 小瀬 亮太, Tatsuhiro Ishida and 松島 得雄 :
発酵ナノセルロースの大量生産とその応用,
Nankodo, Tokyo, Feb. 2019.
8. Lila Selim Ahmed Ali Abu Amr, J Szebeni. and Tatsuhiro Ishida :
Accelerated blood clearance phenomenon and complement activation-related pseudoallergy: two sides of the same coin,
Pan Stanford Publishing, Jan. 2019.
9. Lila Selim Ahmed Ali Abu Amr and Tatsuhiro Ishida :
Anti-PEG immunity against PEGylated therapeutics.,
Pan Stanford Publishing, Jan. 2019.
10. Lila Selim Ahmed Ali Abu Amr and Tatsuhiro Ishida :
The accelerated blood clearance (ABC) phenomenon of PEGylated nanocarriers.,
Pan Stanford Publishing, Jan. 2019.
11. Lila Selim Ahmed Ali Abu Amr and Tatsuhiro Ishida :
Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery,
Springer, Jan. 2019.
12. Lila Selim Ahmed Ali Abu Amr and Tatsuhiro Ishida :
Immune response to PEGylated nanomedicines: Impact of IgM Response,
The Springer International Publishing AG, Jun. 2018.
13. Lila Selim Ahmed Ali Abu Amr, Taro Shimizu and Tatsuhiro Ishida :
PEGylation and anti-PEG antibodies.,
Pan Stanford Publishing, Jan. 2018.
14. Tatsuhiro Ishida :
ドラッグデリバリーシステム(DDS,薬物送達システム),
Nankodo, Mar. 2017.
15. Tatsuhiro Ishida and Hidenori ANDO :
ドラッグデリバリーシステム(DDS),
京都廣川書店, 2015.
16. Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and T Allen :
Liposomal nanomedicine,
World Scientific, Oct. 2014.
17. Tatsuhiro Ishida and Hiroshi Kiwada :
腫瘍内微小環境の能動的制御に基づくDDSの開発とがん治療への応用,
CMC Publishing Co.,Ltd., Jun. 2013.
18. Masako Ichihara, Naoto Moriyoshi, Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Anti-PEG IgM production via a PEGylated nano-carrier system for nucleic acid delivery.,
Springer, Jun. 2012.
(DOI: 10.1007/978-1-62703-140-0_4,   PubMed: 23070762)
19. 秋田 英万 and Tatsuhiro Ishida :
新しい剤形:ドラッグデリバリーシステム,
Nankodo, Dec. 2011.
20. Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Cationic liposomes and tumour vasculature targeting: a therapeutic approach that has potential for solid tumours.,
Souto, E.B. (Ed.), i-Smithers - Creative Publishing Solutions, Aug. 2011.
21. Yusuke Doi, Tatsuhiro Ishida and Hiroshi Kiwada :
Breaking the barriers to tumor-targeting via nanocarrier-based drug delivery to the tumor microenvironment.,
Nova Science Publishers, 2010.
22. Jose Mario Barichello, Tatsuhiro Ishida and Hiroshi Kiwada :
Complexation of siRNA and pDNA with cationic liposomes: The important aspects in lipoplex preparation.,
A chapter, Liposomes, Methods Mol. Biol., 2010.
(DOI: 10.1007/978-1-60327-360-2_32,   PubMed: 20072901)
23. Tatsuhiro Ishida and Hiroshi Kiwada :
Synergistic antitumor activity of metronomic dosing chemotherapy in combination with liposomal anticancer drug.,
Nova Science Publishers, Apr. 2009.
24. Tatsuhiro Ishida and Hiroshi Kiwada :
Unexpected reactions by in vivo application of PEGylated liposomes.,
Springer Science + Business Media, New York, USA, 2009.
25. Tatsuhiro Ishida and Hiroshi Kiwada :
第10章医学薬学でのリポソーム応用 1節リポソームと細胞の相互作用,
NTS Inc., Tokyo, Jun. 2005.
26. Tatsuhiro Ishida and Hiroshi Kiwada :
第10章医学薬学でのリポソーム応用 3節長期血中滞留性リポソーム,
NTS Inc., Tokyo, Jun. 2005.

Academic Paper (Judged Full Paper):

1. Takeru Hirai, Mayumi Ikeda-Imafuku, Nanami Tasaka, Chuang Tuan Giam Victor, Xian Ming, Tatsuhiro Ishida, Takaaki Akaike and Yu Ishima :
Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides,
Advances in Redox Research, Vol.10, 100091, 2024.
(DOI: 10.1016/j.arres.2023.100091)
2. Gaballa A Sherif, Taro Shimizu, Haruka Takata, Hidenori ANDO, Ibrahim Mohamed, Emam Emam Abdallah Sherif, Nana Amorim Cristina Matsuo, Yuri Kim, Naguib W Youssef, Mady M Fatma, Khaled A Khaled and Tatsuhiro Ishida :
Impact of anti-PEG IgM induced via the topical application of a cosmetic product containing PEG derivatives on the antitumor effects of PEGylated liposomal antitumor drug formulations in mice,
Molecular Pharmaceutics, Vol.21, No.2, 622-632, 2024.
(DOI: 10.1021/acs.molpharmaceut.3c00774)
3. Taro Shimizu, Lila S Abu Amr, Yuka Kitayama, Ryo Abe, Haruka Takata, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Peritoneal B Cells Play a Role in The Production of Anti-Polyethylene Glycol (PEG) IgM Against Intravenously Injected siRNA-PEGylated Liposome Complexes,
Biological & Pharmaceutical Bulletin, Vol.47, No.2, 469-477, 2024.
(DOI: 10.1248/bpb.b23-00733)
4. Mayumi Ikeda-Imafuku, Tatsuya Fukuta, Chuang Tuan Giam Victor, Tomohiro Sawa, Toru Maruyama, Masaki Otagiri, Tatsuhiro Ishida and Yu Ishima :
Acute kidney injury caused by rhabdomyolysis is ameliorated by serum albumin-based supersulfides donors through antioxidative pathways,
Pharmaceuticals, Vol.17, No.1, 128, 2024.
(DOI: 10.3390/ph17010128)
5. Hiromi Sakai, Tomoko Kure, Naoko Kobayashi, Tadashi Ito, Yasushi Yamada, Tetsuya Yamada, Rina Miyamoto, Takahito Imaizumi, Jiro Ando, Takaomi Soga, Yasuo Osanai, Makoto Ogawa, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Azuma :
Absence of Anaphylactic Reactions to Injection of Hemoglobin-vesicles (Artificial Red Cells) to Rodents,
ACS Omega, Vol.9, No.1, 1904-1915, 2024.
(DOI: 10.1021/acsomega.3c08641)
6. 横山 宏司, 儘田 光和, Haruka Takata, Taro Shimizu, Hidenori ANDO and Tatsuhiro Ishida :
マクロゴール4000の関連する全身性紅斑を呈した女児例,
Pediatrics of Japan, Vol.64, No.11, 1196-1199, 2023.
(DOI: 10.18888/sh.0000002763)
7. Kengo Yasuda, Hitoshi Maeda, Ryo Kinoshita, Yuki Minayoshi, Yuki Mizuta, Yuka Nakamura, Shuhei Imoto, Koji Nishi, Keishi Yamasaki, Mina Sakuragi, Teruya Nakamura, Mayumi Ikeda-Imafuku, Yasunori Iwao, Yu Ishima, Tatsuhiro Ishida, Yasuko Iwakiri, Masaki Otagiri, Hiroshi Watanabe and Toru Maruyama :
Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticle for the Treatment of Hepatitis,
ACS Nano, Vol.17, No.17, 16668-16681, 2023.
(DOI: 10.1021/acsnano.3c02877,   PubMed: 37579503,   Elsevier: Scopus)
8. Haruka Takata, Taro Shimizu, Rina Yamade, Nehal Ali Emam Elsadek Emam Elhewan, Sherif Abdallah Emam Emam, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Anti-PEG IgM production induced by PEGylated liposomes as a function of administration route,
Journal of Controlled Release, Vol.360, 285-292, 2023.
(DOI: 10.1016/j.jconrel.2023.06.027,   PubMed: 37355210)
9. Hidenori ANDO, Kiyoshi Eshima and Tatsuhiro Ishida :
A polyethylene glycol-conjugate of deoxycytidine analog, DFP-14927, produces potential antitumor effects on pancreatic tumor-xenograft murine models via inducing G2/M arrest,
European Journal of Pharmacology, Vol.950, 175758, 2023.
(DOI: 10.1016/j.ejphar.2023.175758,   PubMed: 37121563)
10. Taro Shimizu, Takaaki Matsuzaki, Shoishiro Fukuda, Chihiro Yoshioka, Yuna Shimazaki, Shunsuke Takese, Katsuhiro Yamanaka, Takashi Nakae, Masaki Ishibashi, Hidetoshi Hamamoto, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Ionic liquid-based transcutaneous peptide antitumor vaccine; therapeutic effect in a mouse tumor model,
The AAPS Journal, Vol.25, No.2, 27, 2023.
(DOI: 10.1208/s12248-023-00790-w,   PubMed: 36805860)
11. Mohamed Ibrahim, Taro Shimizu, Hidenori ANDO, Yu Ishima, Helmy Omar Elgarhy, A Hatem Sarhan, K Amal Hussein and Tatsuhiro Ishida :
Investigation of anti-PEG antibody response to PEG-containing cosmetic products in mice,
Journal of Controlled Release, Vol.354, 260-267, 2023.
(DOI: 10.1016/j.jconrel.2023.01.012)
12. Ayano Sawa-Aihara, Katsuji Hattori, Goshi Nagao, Yoshihisa Yamada and Tatsuhiro Ishida :
Potential efficacy of proteasome inhibitor, Delanzomib, for the treatment of renal fibrosis,
Biological & Pharmaceutical Bulletin, Vol.46, No.2, 279-285, 2023.
(DOI: 10.1248/bpb.b22-00713)
13. Naoto Okada, Taro Shimizu, Hidenori ANDO, Shingen Nakamura, Mitsuhiro Goda, Masahiro Abe, Takashi Kitahara, Tatsuhiro Ishida and Keisuke Ishizawa :
Clinical impact of anti-polyethylene glycol (PEG) antibody in haematological patients administered PEGylated-granulocyte colony-stimulating factor,
Clinical Pharmacology in Drug Development, Vol.12, No.8, 826-831, 2023.
(DOI: 10.1002/cpdd.1225,   PubMed: 36708147)
14. Kohki Tachibana, Kohshi Kusumoto, Mai Ogawa, Hidenori ANDO, Taro Shimizu, Yu Ishima, Tatsuhiro Ishida and Keiichiro Okuhira :
FTY720 reduces lipid accumulation by upregulating ABCA1 through liver X receptor and sphingosine kinase 2 signaling in macrophages,
International Journal of Molecular Sciences, Vol.23, 14617, 2022.
(Tokushima University Institutional Repository: 118017,   DOI: 10.3390/ijms232314617)
15. Hiroshi Azuma, Toraji Amano, Naoya Kamiyama, Naofumi Takehara, Maki Jingu, Harumi Takagi, Osamu Sugita, Naoko Kobayashi, Tomoko Kure, Taro Shimizu, Tatsuhiro Ishida, Masanori Matsumoto and Hiromi Sakai :
First-in-human Phase 1 trial of artificial red blood cells, hemoglobin vesicles, developed as a transfusion alternative,
Blood Advances, Vol.6, No.21, 5711-5715, 2022.
(Tokushima University Institutional Repository: 117961,   DOI: 10.1182/bloodadvances.2022007977,   PubMed: 35939788)
16. Yu Ishima, Nio Yamazaki, V Chuang, Taro Shimizu, Hidenori ANDO and Tatsuhiro Ishida :
A maleimide-terminally modified PEGylated liposome induced the accelerated blood clearance independent of the production of anti-PEG IgM antibodies,
Biological & Pharmaceutical Bulletin, Vol.45, No.10, 1518-1524, 2022.
(DOI: 10.1248/bpb.b22-00389,   CiNii: 1390856583390911232)
17. Yu Ishima, 小田切 優樹 and Tatsuhiro Ishida :
アルブミンのボリスルフィドによる新たな生体恒常性維持機構,
人工血液, Vol.30, 59-64, 2022.
18. Hidenori ANDO, Ai Ikeda, Maho Tagami, Nana Matsuo, Taro Shimizu, Yu Ishima, K Eshima and Tatsuhiro Ishida :
Oral administration of sodium bicarbonate can enhance the therapeutic outcome of Doxil® via neutralizing the acidic tumor microenvironment,
Journal of Controlled Release, Vol.350, 414-420, 2022.
(DOI: 10.1016/j.jconrel.2022.08.031,   PubMed: 35988781)
19. Yoshino Kawaguchi, Taro Shimizu, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Development of a nanocarrier-based splenic B cell-targeting system for loading antigens in vitro,
Biological & Pharmaceutical Bulletin, Vol.45, No.7, 926-933, 2022.
(Tokushima University Institutional Repository: 117224,   DOI: 10.1248/bpb.b22-00222)
20. Taro Shimizu, Yoshino Kawaguchi, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Development of an antigen delivery system for a B cell-targeted vaccine as an alternative to dendritic cell-targeted vaccines,
Chemical & Pharmaceutical Bulletin, Vol.70, No.5, 341-350, 2022.
(DOI: 10.1248/cpb.c22-00047)
21. Takaki Nakajima, Kazuya Nagano, Yuka Fukuda, Yu Ishima, Hiroko Shibata, Ryo Isaka, Tian-Qi Zhang, Yuya Haga, Kazuma Higashisaka, Hirofumi Tsujino, Tatsuhiro Ishida, Akiko Ishii-Watabe and Yasuo Tsutsumi :
Subvisible particles derived by dropping stress enhance anti-PEG antibody production and clearance of PEGylated proteins in mice,
Journal of Pharmaceutical Sciences, Vol.111, No.5, 1363-1369, 2022.
(DOI: 10.1016/j.xphs.2022.01.023)
22. Ryota Sumitomo, Cheng-long Huang, Hidenori ANDO, Tatsuhiro Ishida, Hiroyuki Cho and Hiroshi Date :
Wnt2b and Wnt5a expressions are highly associated with M2 TAMs in non-small-cell lung cancer,
Oncology Reports, Vol.48, No.5, 189, 2022.
(DOI: 10.2139/ssrn.4088768,   PubMed: 36102318)
23. Kazuya Nakamura, Keisuke Aihara and Tatsuhiro Ishida :
Importance of process parameters influencing the mean diameters of siRNA-containing lipid nanoparticles (LNPs) on the in vitro activity of prepared LNPs,
Biological & Pharmaceutical Bulletin, Vol.45, No.4, 497-507, 2022.
(DOI: 10.1248/bpb.b21-01016)
24. Marwa Sayed El, Taro Shimizu, Lila Selim Ahmed Ali Abu Amr, Elhewan Emam Elsadek Emam Ali Nehal, Emam Emam Abdallah Sherif, Eman Alaaeldin, Amal Kamal, Hatem Sarhan, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
A mouse model for studying the effect of blood anti-PEG IgMs levels on the in vivo fate of PEGylated liposomes,
International Journal of Pharmaceutics, Vol.615, 121539, 2022.
(DOI: 10.1016/j.ijpharm.2022.121539,   PubMed: 35124114)
25. M Mostafa Mahmoud, Elhewan Emam Elsadek Emam Ali Nehal, Emam Emam Abdallah Sherif, Hidenori ANDO, Taro Shimizu, H Abdelkader, Yu Ishima, U Aly Farghaly, A H Sarhan and Tatsuhiro Ishida :
Using Bio-Layer Interferometry to evaluate anti-PEG antibody-mediated complement activation,
Biological & Pharmaceutical Bulletin, Vol.45, No.1, 129-135, 2022.
(DOI: 10.1248/bpb.b21-00772)
26. Rie Ando-Matsuoka, Hidenori ANDO, Lila Selim Ahmed Ali Abu Amr, Noriyuki Maeda, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors,
Journal of Controlled Release, Vol.341, 524-532, 2022.
(DOI: 10.1016/j.jconrel.2021.12.004)
27. Keisuke Mogi, Ikumi Kamiya, Aimi Makino, Ayaka Hirao, Reina Abe, Yusuke Doi, Taro Shimizu, Hidenori ANDO, Katsuya Morito, Kentaro Takayama, Tatsuhiro Ishida and Kazuki Nagasawa :
Liposomalization of oxaliplatin exacerbates the non-liposomal formulation-induced decrease of sweet taste sensitivity in rats,
Journal of Pharmaceutical Sciences, Vol.110, No.12, 3937-3945, 2021.
(DOI: 10.1016/j.xphs.2021.07.004)
28. Eisaku Ohashi, Sangita Karanjit, Atsushi Nakayama, Kohei Takeuchi, Sherif E Emam, Hidenori ANDO, Tatsuhiro Ishida and Kosuke Namba :
Efficient construction of the hexacyclic ring core of palau'amine: the pKa concept for proceeding with unfavorable equilibrium reactions,
Chemical Science, Vol.12, 2021.
(Tokushima University Institutional Repository: 116279,   DOI: 10.1039/D1SC03260G)
29. Kazuyuki Saito, Taro Shimizu, Katsue Suzuki-Inoue, Tatsuhiro Ishida and Yoshiaki Wada :
Aseptic meningitis after vaccination of the BNT162b2 mRNA COVID19 vaccine,
Neurological Sciences, 2021.
(DOI: 10.1007/s10072-021-05543-1)
30. Ryo Kinoshita, Yu Ishima, Victor T.G. Chuang, Hiroshi Watanabe, Taro Shimizu, Hidenori ANDO, Keiichiro Okuhira, Masaki Otagiri, Tatsuhiro Ishida and Toru Maruyama :
The therapeutic effect of HSA dimer-doxorubicin complex against human pancreatic tumour,
Pharmaceutics, Vol.13, No.8, 1209, 2021.
(Tokushima University Institutional Repository: 116618,   DOI: 10.3390/pharmaceutics13081209)
31. Hidenori ANDO, Takashi Mochizuki, Amr Abu Ali Ahmed Selim Lila, Shunsuke Akagi, Kenji Tajima, Kenji Fujita, Taro Shimizu, Yu Ishima, Tokuo Matsushima, Takatomo Kusano and Tatsuhiro Ishida :
Doxorubicin embedded into nanofibrillated bacterial cellulose (NFBC) produces a promising therapeutic outcome for peritoneally metastatic gastric cancer in mice models via intraperitoneal direct injection,
Nanomaterials, Vol.11, 1697, 2021.
(Tokushima University Institutional Repository: 116603,   DOI: 10.3390/nano11071697)
32. Emam Emam Abdallah Sherif, Elhewan Emam Elsadek Emam Ali Nehal, Lila Selim Ahmed Ali Abu Amr, Haruka Takata, Yoshino Kawaguchi, Taro Shimizu, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Anti-PEG IgM production and accelerated blood clearance phenomenon after the administration of PEGylated exosomes in mice,
Journal of Controlled Release, Vol.334, 327-334, 2021.
(DOI: 10.1016/j.jconrel.2021.05.001,   PubMed: 33957196,   Elsevier: Scopus)
33. Milad Reda Qelliny, Taro Shimizu, Nehal Ali Emam Elsadek Emam Elhewan, Sherif Abdallah Emam Emam, Haruka Takata, Zeinab M. A. Fathalla, Amal K. Hussein, Khaled A. Khaled, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Incorporating gangliosides into PEGylated cationic liposomes that complexed DNA attenuates anti-PEG antibody production, but not anti-DNA antibody production in mice,
Molecular Pharmaceutics, Vol.18, No.6, 2406-2415, 2021.
(DOI: 10.1021/acs.molpharmaceut.1c00255,   PubMed: 33896187)
34. Hidenori ANDO, Yuta Murakami, Kiyoshi Eshima and Tatsuhiro Ishida :
A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML),
Cancer Reports, Vol.5, No.3, e1485, 2021.
(Tokushima University Institutional Repository: 116506,   DOI: 10.1002/cnr2.1485,   PubMed: 34173723)
35. Hidenori ANDO, Sherif Abdallah Emam Emam, Yoshino Kawaguchi, Taro Shimizu, Yu Ishima, Kiyoshi Eshima and Tatsuhiro Ishida :
Increasing tumor extracellular pH by an oral alkalinizing agent improves antitumor responses of anti-PD-1 antibody: Implication of relationships between serum bicarbonate concentrations, urinary pH, and therapeutic outcomes,
Biological & Pharmaceutical Bulletin, Vol.44, No.6, 844-852, 2021.
(DOI: 10.1248/bpb.b21-00076)
36. Naoki Hirakawa, Yu Ishima, Ryo Kinoshita, Ryuto Nakano, Chuang Tuan Giam Victor, Hidenori ANDO, Taro Shimizu, Keiichiro Okuhira, Toru Maruyama, Masaki Otagiri and Tatsuhiro Ishida :
Reduction-responsive and Multi-drug Deliverable Albumin Nanoparticles: an antitumor drug to Abraxane® against Human Pancreatic Tumor-Bearing Mice,
ACS Applied Bio Materials, Vol.4, No.5, 4302-4309, 2021.
(DOI: 10.1021/acsabm.1c00110)
37. Haruka Takata, Taro Shimizu, Yoshino Kawaguchi, Hiro Ueda, Nehal Ali Emam Elsadek Emam Elhewan, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Nucleic acids delivered by PEGylated cationic liposomes in systemic lupus erythematosus-prone mice: a possible exacerbation of lupus nephritis in the presence of pre-existing anti-nucleic acid antibodies,
International Journal of Pharmaceutics, Vol.601, 120529, 2021.
(DOI: 10.1016/j.ijpharm.2021.120529)
38. Maichi Hama, Yu Ishima, Chuang V, Hidenori ANDO, Taro Shimizu and Tatsuhiro Ishida :
Evidence for delivery of Abraxane® via a denatured-albumin transport system,
ACS Applied Materials & Interfaces, Vol.13, No.17, 19736-19744, 2021.
(DOI: 10.1021/acsami.1c03065)
39. Shunsuke Akagi, Hidenori ANDO, Kenji Fujita, Taro Shimizu, Yu Ishima, Kenji Tajima, Tokuo Matsushima, Takatomo Kusano and Tatsuhiro Ishida :
Therapeutic efficacy of a paclitaxel-loaded nanofibrillated bacterial cellulose (PTX/NFBC) formulation in a peritoneally disseminated gastric cancer xenograft model,
International Journal of Biological Macromolecules, Vol.174, 494-501, 2021.
(DOI: 10.1016/j.ijbiomac.2021.01.201)
40. Taro Shimizu, Yuki Watanabe, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Lymphoid follicle antigen (Ag) delivery and enhanced rodent humoral immune responses mediated by Ag-containing PEGylated liposomes,
Vaccine, Vol.39, No.7, 1131-1139, 2021.
(DOI: 10.1016/j.vaccine.2021.01.008)
41. Hidenori ANDO, Kiyoshi Eshima and Tatsuhiro Ishida :
Neutralization of acidic tumor microenvironment (TME) with daily oral dosing of sodium potassium citrate (K/Na Citrate) increases therapeutic effect of anti-cancer agent in pancreatic cancer xenograft mice model,
Biological & Pharmaceutical Bulletin, Vol.44, No.2, 266-270, 2021.
(DOI: 10.1248/bpb.b20-00825)
42. Taro Shimizu, Mizuki Awata, Lila Selim Ahmed Ali Abu Amr, Chihiro Yoshioka, Yoshino Kawaguchi, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes,
Journal of Controlled Release, Vol.329, 1046-1053, 2021.
(DOI: 10.1016/j.jconrel.2020.10.033)
43. Takuma Takayama, Taro Shimizu, Lila Selim Ahmed Ali Abu Amr, Yuki Kanazawa, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Adjuvant antitumor immunity contributes to the overall antitumor effect of PEGylated liposomal doxorubicin (Doxil®) in C26 tumor-bearing immunocompetent mice,
Pharmaceutics, Vol.12, No.10, 990, 2020.
(Tokushima University Institutional Repository: 116247,   DOI: 10.3390/pharmaceutics12100990)
44. Takuya Suzuki, Yuta Suzuki, Taro Hihara, Kenji Kubara, Keita Kondo, Kenji Hyodo, Kazuto Yamazaki, Tatsuhiro Ishida and Hiroshi Ishihara :
PEG shedding-rate-dependent blood clearance of PEGylated lipid nanoparticles in mice: faster PEG shedding attenuates anti-PEG IgM production,
International Journal of Pharmaceutics, Vol.588, 119792, 2020.
(DOI: 10.1016/j.ijpharm.2020.119792)
45. Shota Fuimoto, Naoki Muguruma, Michiyasu Nakao, Hidenori ANDO, Takanori Kashihara, Yoshihiko Miyamoto, Koichi Okamoto, Shigeki Sano, Tatsuhiro Ishida, Yasushi Sato and Tetsuji Takayama :
Indocyanine green-labeled dasatinib as a new fluorescent probe for molecular imaging of gastrointestinal stromal tumors.,
Journal of Gastroenterology and Hepatology, Vol.36, No.5, 1253-1262, 2020.
(DOI: 10.1111/jgh.15281,   PubMed: 32989784)
46. Elhewan Emam Elsadek Emam Ali Nehal, Emam Emam Abdallah Sherif, Lila Selim Ahmed Ali Abu Amr, Taro Shimizu, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Pegfilgrastim (PEG-G-CSF) induces anti-polyethylene glycol (PEG) IgM via a T cell-dependent mechanism,
Biological & Pharmaceutical Bulletin, Vol.43, No.9, 1393-1397, 2020.
(DOI: 10.1248/bpb.b20-00345,   PubMed: 32879214)
47. Takaaki Ryujin, Taro Shimizu, Ryo Miyahara, Daisuke Asai, Rena Shimazui, Takuma Yoshikawa, Akihiro Kishimura, Takeshi Mori, Tatsuhiro Ishida and Yoshiki Katayama :
Blood retention and antigenicity of polycarboxybetaine-modified liposomes,
International Journal of Pharmaceutics, Vol.586, 119521, 2020.
(DOI: 10.1016/j.ijpharm.2020.119521,   PubMed: 32561308,   Elsevier: Scopus)
48. A Nguyen, Hidenori ANDO, R Böttger, K K Viswanadham, E Rouhollahi, Tatsuhiro Ishida and S Li :
Utilization of Click Chemistry to Study the Effect of Poly(ethylene) Glycol Molecular Weight on the Self-Assembly of PEGylated Gambogic Acid Nanoparticles for the Treatment of Rheumatoid Arthritis,
Biomaterials Science, Vol.8, No.16, 4626-4637, 2020.
(DOI: 10.1039/d0bm00711k,   PubMed: 32700691)
49. Elhewan Emam Elsadek Emam Ali Nehal, Eri Hondoh, Taro Shimizu, Haruka Takata, Lila Selim Ahmed Ali Abu Amr, Emam Emam Abdallah Sherif, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Impact of pre-existing or induced anti-PEG IgM on the pharmacokinetics of peginterferon alfa-2a (Pegasys®) in mice,
Molecular Pharmaceutics, Vol.17, No.8, 2964-2970, 2020.
(DOI: 10.1021/acs.molpharmaceut.0c00366,   PubMed: 32519877)
50. M Sayed M El, Haruka Takata, Taro Shimizu, Yoshino Kawaguchi, Lila Selim Ahmed Ali Abu Amr, Elhewan Emam Elsadek Emam Ali Nehal, E Alaaeldin, Yu Ishima, Hidenori ANDO, A Kamal, A H Sarhan and Tatsuhiro Ishida :
Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon,
Journal of Controlled Release, Vol.323, 102-109, 2020.
(DOI: 10.1016/j.jconrel.2020.04.011,   PubMed: 32278827,   Elsevier: Scopus)
51. Nehal Ali Emam Elsadek Emam Elhewan, Amr Abu Ali Ahmed Selim Lila, Sherif Abdallah Emam Emam, Taro Shimizu, Haruka Takata, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Pegfilgrastim (PEG-G-CSF) induces anti-PEG IgM in a dose dependent manner and causes the accelerated blood clearance (ABC) phenomenon upon repeated administration in mice,
European Journal of Pharmaceutics and Biopharmaceutics, Vol.152, 56-62, 2020.
(DOI: 10.1016/j.ejpb.2020.04.026,   PubMed: 32376372)
52. Yukiko Oh, Hitomi Niijima, Yuta Kawahara, Tomomi Hayase, Taro Shimizu, Tatsuhiro Ishida and Akira Morimoto :
An immediate hypersensitivity reaction induced by PEGylated recombinant factor VIII,
Haemophilia, 2020.
(DOI: 10.1111/hae.14048)
53. Ryo Koba, Hayato Fujita, Maiko Nishibori, Kiyoshi Saeki, Kinuko Nagayoshi, Yoshihiko Sadakari, Shuntaro Nagai, Oki Sekizawa, Kiyofumi Nitta, Tatsuya Manabe, Takashi Ueki, Tatsuhiro Ishida, Yoshinao Oda and Masafumi Nakamura :
Quantitative evaluation of the intratumoral distribution of platinum in oxaliplatin-treated rectal cancer: In situ visualization of platinum via synchrotron radiation X-ray fluorescence spectrometry,
International Journal of Cancer, Vol.146, No.9, 2498-2509, 2020.
(DOI: 10.1002/ijc.32592,   PubMed: 31344279,   Elsevier: Scopus)
54. Hidenori ANDO, Noriko Saito-Tarashima, Lila Selim Ahmed Ali Abu Amr, Nozomi Kinjoh, Taro Shimizu, Yu Ishima, Noriaki Minakawa and Tatsuhiro Ishida :
A unique gene-silencing approach, using an intelligent RNA expression device (iRed), results in minimal immune stimulation when given by local intrapleural injection in malignant pleural mesothelioma,
Molecules, Vol.25, No.7, 1725, 2020.
(Tokushima University Institutional Repository: 115605,   DOI: 10.3390/molecules25071725,   PubMed: 32283709,   Elsevier: Scopus)
55. Yu Ishima, Ai Minomo, Chuang Tuan Giam Victor, Tetsuya Fukuda, Kohshi Kusumoto, Keiichiro Okuhira, Yoshiaki Suwa, Hiroshi Watanabe, Tatsuhiro Ishida, Hiroshi Morioka, Toru Maruyama and Masaki Otagiri :
Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment,
IUBMB life, Vol.72, No.4, 641-651, 2020.
(DOI: 10.1002/iub.2203,   PubMed: 31794135,   Elsevier: Scopus)
56. Tasuku Torao, Miyuki Mimura, Yasufumi Ohshima, Kohki Fujikawa, Mahadi Hasan, Tatsuharu Shimokawa, Naoshi Yamazaki, Hidenori ANDO, Tatsuhiro Ishida, Tatsuya Fukuta, Tamotsu Tanaka and Kentaro Kogure :
Characteristics of unique endocytosis induced by weak current for cytoplasmic drug delivery,
International Journal of Pharmaceutics, Vol.576, 119010, 2020.
(Tokushima University Institutional Repository: 114728,   DOI: 10.1016/j.ijpharm.2019.119010)
57. Emam Emam Abdallah Sherif, Lila Selim Ahmed Ali Abu Amr, Elhewan Emam Elsadek Emam Ali Nehal, Hidenori ANDO, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, M Mahdy, E Ghazy and Tatsuhiro Ishida :
Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues,
European Journal of Pharmaceutics and Biopharmaceutics, Vol.145, 27-34, 2019.
(DOI: 10.1016/j.ejpb.2019.10.005,   PubMed: 31629787,   Elsevier: Scopus)
58. Hidenori ANDO, M Fukushima, K Eshima, Taichi Hasui, Taro Shimizu, Yu Ishima, C Huang, H Wada and Tatsuhiro Ishida :
A novel intraperitoneal therapy for gastric cancer with DFP-10825, a unique RNAi therapeutic targeting thymidylate synthase, in peritoneally disseminated xenograft model,
Cancer Medicine, Vol.8, No.17, 7313-7321, 2019.
(Tokushima University Institutional Repository: 115036,   DOI: 10.1002/cam4.2598,   PubMed: 31609087)
59. Taro Shimizu, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
PEG修飾リポソームに対する免疫応答,
人工血液, Vol.27, 37-43, 2019.
60. S Ichimizu, H Watanabe, H Maeda, K Hamasaki, K Ikegami, V Chuang, Ryo Kinoshita, K Nishida, Taro Shimizu, Yu Ishima, Tatsuhiro Ishida, T Seki, H Katsuki, S Futaki, M Otagiri and T Maruyama :
Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape,
Journal of Controlled Release, Vol.304, 156-163, 2019.
(DOI: 10.1016/j.jconrel.2019.05.015,   PubMed: 31082432,   Elsevier: Scopus)
61. Hidenori ANDO, Lila Selim Ahmed Ali Abu Amr, M Fukushima, Rie Matsuoka, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, C Huang, H Wada and Tatsuhiro Ishida :
A simplified method for manufacturing RNAi therapeutics for local administration,
International Journal of Pharmaceutics, Vol.564, 256-262, 2019.
(DOI: 10.1016/j.ijpharm.2019.04.054,   PubMed: 31015002,   Elsevier: Scopus)
62. Yusuke Doi, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
Long-term storage of PEGylated liposomal oxaliplatin with improved stability and long circulation times in vivo,
International Journal of Pharmaceutics, Vol.564, 237-243, 2019.
(DOI: 10.1016/j.ijpharm.2019.04.042,   PubMed: 31002935,   Elsevier: Scopus)
63. Haruka Kawahara, Naoki Miyashita, Kohki Tachibana, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira :
A photo-activatable peptide mimicking functions of apolipoprotein A-I,
Biological & Pharmaceutical Bulletin, Vol.42, No.6, 1019-1024, 2019.
(DOI: 10.1248/bpb.b19-00114,   PubMed: 31155576,   Elsevier: Scopus)
64. Mayumi Ikeda, Yu Ishima, VTG Chuang, Maki Sakai, Hiroki Osafune, Hidenori ANDO, Taro Shimizu, Keiichiro Okuhira, H Watanabe, T Maruyama, M Otagiri, T Akaike and Tatsuhiro Ishida :
Distribution of Polysulfide in Human Biological Fluids and Their. Association with Amylase and Sperm Activities,
Molecules, Vol.24, No.9, 1689, 2019.
(Tokushima University Institutional Repository: 115606,   DOI: 10.3390/molecules24091689,   PubMed: 31052207,   Elsevier: Scopus)
65. Yosuke Seki, Yoshihiko Ueno, Maiko Sawada and Tatsuhiro Ishida :
入学者選抜の評価を支援する分散評価システムの開発と導入 ―薬学部AO入試における書類審査での活用事例から―,
The Journal of University Admissions Research, No.29, 217-222, 2019.
(CiNii: 1523669554920042240)
66. Yu Ishima, Kaori Watanabe, Victor T. G. Chuang, Iyo Takeda, Teruo Kuroda, Wakano Ogawa, Hiroshi Watanabe, Yasunori Iwao, Tatsuhiro Ishida, Masaki Otagiri and Toru Maruyama :
S-Nitrosated alpha-1-acid glycoprotein exhibits antibacterial activity against multidrug-resistant bacteria strains and synergistically enhances the effect of antibiotics,
FASEB BioAdvances, Vol.1, No.3, 137-150, 2019.
(Tokushima University Institutional Repository: 116302,   DOI: 10.1096/fba.1018,   PubMed: 32123826)
67. Taro Shimizu, Lila Selim Ahmed Ali Abu Amr, Mizuki Awata, Yukiyo Kubo, Yu Mima, Yosuke Hashimoto, Hidenori ANDO, Keiichiro Okuhira, Yu Ishima and Tatsuhiro Ishida :
A cell assay for detecting anti-PEG immune response against PEG-modified therapeutics,
Pharmaceutical Research, Vol.35, No.11, 223, 2018.
(DOI: 10.1007/s11095-018-2505-3,   PubMed: 30280273,   Elsevier: Scopus)
68. Taro Shimizu, Lila Selim Ahmed Ali Abu Amr, Yoshino Kawaguchi, Yuna Shimazaki, Yu Mima, Yosuke Hashimoto, Keiichiro Okuhira, G Storm, Yu Ishima and Tatsuhiro Ishida :
A novel platform for cancer vaccines: Antigen-selective delivery to splenic marginal zone B cells via repeated injections of PEGylated liposomes,
The Journal of Immunology, Vol.201, No.10, 2969-2976, 2018.
(DOI: 10.4049/jimmunol.1701351,   PubMed: 30333124)
69. T Mészáros, G Kozma, Taro Shimizu, Kohga Miyahara, K Turjeman, Tatsuhiro Ishida, Y Barenholz, R Urbanics and J Szebeni :
Involvement of complement activation in the pulmonary vasoactivity of polystyrene nanoparticles in pigs: Unique surface properties underlying alternative pathway activation and instant opsonization,
International Journal of Nanomedicine, Vol.13, 6345-6357, 2018.
(Tokushima University Institutional Repository: 115154,   DOI: 10.2147/IJN.S161369,   PubMed: 30349254)
70. Emam Emam Abdallah Sherif, Hidenori ANDO, Lila Selim Ahmed Ali Abu Amr, Taro Shimizu, Keiichiro Okuhira, Yu Ishima, M Mahdy, F Ghazy, I Sagawa and Tatsuhiro Ishida :
Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways,
Scientific Reports, Vol.8, No.1, 14493, 2018.
(Tokushima University Institutional Repository: 114955,   DOI: 10.1038/s41598-018-32861-w,   PubMed: 30262875,   Elsevier: Scopus)
71. Emam Emam Abdallah Sherif, Hidenori ANDO, Lila Selim Ahmed Ali Abu Amr, Shinya Kobayashi, Taro Shimizu, Keiichiro Okuhira, Yu Ishima and Tatsuhiro Ishida :
Doxorubicin expands in vivo secretion of circulating exosome in mice,
Biological & Pharmaceutical Bulletin, Vol.41, No.7, 1078-1083, 2018.
(DOI: 10.1248/bpb.b18-00202,   PubMed: 29962402,   Elsevier: Scopus)
72. Taro Shimizu, Lila Selim Ahmed Ali Abu Amr, Risako Fujita, Mizuki Awata, Munehira Kawanishi, Yosuke Hashimoto, Keiichiro Okuhira, Yu Ishima and Tatsuhiro Ishida :
A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes,
European Journal of Pharmaceutics and Biopharmaceutics, Vol.127, 142-149, 2018.
(DOI: 10.1016/j.ejpb.2018.02.019,   PubMed: 29462689,   Elsevier: Scopus)
73. Emam Emam Abdallah Sherif, Hidenori ANDO, Lila Selim Ahmed Ali Abu Amr, Taro Shimizu, Masami Ukawa, Keiichiro Okuhira, Yu Ishima, A M Mahdy, S F Ghazy and Tatsuhiro Ishida :
A novel strategy to increase the yield of exosomes (extracellular vesicles) for an expansion of basic research,
Biological & Pharmaceutical Bulletin, Vol.41, No.5, 733-742, 2018.
(DOI: 10.1248/bpb.b17-00919,   PubMed: 29709910,   Elsevier: Scopus)
74. Yuki Minayoshi, Hitoshi Maeda, Hiroki Yanagisawa, Keisuke Hamasaki, Yuki Mizuta, Kento Nishida, Ryo Kinoshita, Yuki Enoki, Tadasi Imafuku, Giam Victor Tuan Chuang, Tomoaki Koga, Yukiko Fujiwara, Motohiro Takeya, Kayoko Sonoda, Tomohiro Wakayama, Kazuaki Taguchi, Yu Ishima, Tatsuhiro Ishida, Yasuko Iwakiri, Motohiko Tanaka, Yutaka Sasaki, Hiroshi Watanabe, Masako Otagiri and Toru Maruyama :
Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions,
Drug Delivery, Vol.25, No.1, 1067-1077, 2018.
(Tokushima University Institutional Repository: 115087,   DOI: 10.1080/10717544.2018.1464083,   PubMed: 29688069,   Elsevier: Scopus)
75. 田島 健次, 小瀬 亮太, Tatsuhiro Ishida and 松島 得雄 :
発酵ナノセルロース(NFBC)の大量生産とその医療応用,
BIO INDUSTRY, Vol.35, No.4, 55-63, 2018.
76. M Ikeda, Yu Ishima, R Kinoshita, V Chuang, N Tasaka, N Matsuo, H Watanabe, Taro Shimizu, Tatsuhiro Ishida, M Otagiri and T Maruyama :
A Novel S-Sulfhydrated Human Serum Albumin Preparation Suppresses Melanin Synthesis,
Redox Biology, Vol.14, 354-360, 2018.
(Tokushima University Institutional Repository: 115707,   DOI: 10.1016/j.redox.2017.10.007,   PubMed: 29040960,   Elsevier: Scopus)
77. Hidenori ANDO, Lila Selim Ahmed Ali Abu Amr, Masao Tanaka, Yusuke Doi, Yasuko Terada, Naoto Yagi, Taro Shimizu, Keiichiro Okuhira, Yu Ishima and Tatsuhiro Ishida :
Intratumoral visualization of oxaliplatin within a liposomal formulation using X-ray fluorescence spectrometry,
Molecular Pharmaceutics, Vol.15, No.2, 403-409, 2018.
(DOI: 10.1021/acs.molpharmaceut.7b00762,   PubMed: 29287147,   Elsevier: Scopus)
78. Hidenori ANDO, Lila Selim Ahmed Ali Abu Amr, Munehira Kawanishi, Taro Shimizu, Keiichiro Okuhira, Yu Ishima and Tatsuhiro Ishida :
Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens,
Journal of Controlled Release, Vol.270, 114-119, 2018.
(DOI: 10.1016/j.jconrel.2017.12.002,   PubMed: 29217175,   Elsevier: Scopus)
79. Sheuli Afroz, Ayano Yagi, Kouki Fujikawa, M. Motiur Rahman, Katsuya Morito, Tatsuya Fukuta, Shiro Watanabe, Kazunori Toida, Emi Kiyokage, Taro Shimizu, Tatsuhiro Ishida, Kentaro Kogure, Akira Tokumura and Tamotsu Tanaka :
Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro,
Prostaglandins & Other Lipid Mediators, Vol.135, 36-44, 2018.
(Tokushima University Institutional Repository: 112025,   DOI: 10.1016/j.prostaglandins.2018.01.003,   PubMed: 29462674,   Elsevier: Scopus)
80. K Tanaka, M Shimoda, V Chuang, K Nishida, M Kawahara, Tatsuhiro Ishida, M Otagiri, T Maruyama and Yu Ishima :
Thioredoxin-Albumin Fusion Protein Prevents Copper enhanced Zinc-induced Neurotoxicity via Its Antioxidative activity,
International Journal of Pharmaceutics, Vol.535, No.1-2, 140-147, 2018.
(DOI: 10.1016/j.ijpharm.2017.11.012,   PubMed: 29122608,   Elsevier: Scopus)
81. Hidenori ANDO and Tatsuhiro Ishida :
放射光施設(SPring-8)における蛍光X線分析法を用いたオキサリプラチン腫瘍内分布解析,
Journal of Pharmaceutical Science and Technology, Japan, Vol.78, No.1, 28-33, 2018.
(DOI: 10.14843/jpstj.78.28,   CiNii: 1390001205741139840)
82. Kentaro Nishida, Misaki Kashiwagi, Shunsuke Shiba, Kiwamu Muroki, Akihiro Ohishi, Yusuke Doi, Hidenori ANDO, Tatsuhiro Ishida and Kazuki Nagasawa :
Liposomalization of oxaliplatin induces skin accumulation of it, but negligible skin toxicity,
Toxicology and Applied Pharmacology, Vol.337, 76-84, 2017.
(DOI: 10.1016/j.taap.2017.10.006,   PubMed: 29054682,   Elsevier: Scopus)
83. Mayumi Ikeda, Yu Ishima, Victor Chuang, Tsuyoshi Ikeda, Ryo Kinoshita, Hiroshi Watanabe, Tatsuhiro Ishida, Masaki Otagiri and Toru Maruyama :
Apoptosis induction of Poly-S-nitrosated human serum albumin in resistant solid tumor under hypoxia can be restored by phosphodiesterase 5 inhibition,
Nitric Oxide: Biology and Chemistry, Vol.69, 28-34, 2017.
(DOI: 10.1016/j.niox.2017.04.005,   PubMed: 28414103)
84. Ryo Kinoshita, Yu Ishima, Victor T.G. Chuang, Hideaki Nakamura, Jun Fang, Hiroshi Watanabe, Taro Shimizu, Keiichiro Okuhira, Tatsuhiro Ishida, Hiroshi Maeda, Masaki Otagiri and Toru Maruyama :
Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-Nitrosated Human Serum Albumin Dimer,
Biomaterials, Vol.140, 162-169, 2017.
(DOI: 10.1016/j.biomaterials.2017.06.021,   PubMed: 28651144,   Elsevier: Scopus)
85. Lila Selim Ahmed Ali Abu Amr, Naoto Moriyoshi, Masakazu Fukushima, Cheng-long Huang, Hiromi Wada and Tatsuhiro Ishida :
Metronomic S-1 dosing and thymidylate synthase silencing have synergistic antitumor efficacy in a colorectal cancer xenograft model.,
Cancer Letters, Vol.400, 223-231, 2017.
(Tokushima University Institutional Repository: 115035,   DOI: 10.1016/j.canlet.2016.11.005,   PubMed: 27838412,   Elsevier: Scopus)
86. Taro Shimizu, Lila Selim Ahmed Ali Abu Amr, Miho Nishio, Yusuke Doi, Hidenori ANDO, Masami Ukawa, Yu Ishima and Tatsuhiro Ishida :
Modulation of antitumor immunity contributes to the enhanced therapeutic efficacy of liposomal oxaliplatin in mouse model,
Cancer Science, Vol.108, No.9, 1864-1869, 2017.
(Tokushima University Institutional Repository: 112372,   DOI: 10.1111/cas.13305,   PubMed: 28643902)
87. Alaaeldin Eman, Lila Selim Ahmed Ali Abu Amr, Hidenori ANDO, M Fukushima, C Huang, H Wada, H.A Sarhan, K.A Khaled and Tatsuhiro Ishida :
Co-administration of liposomal l-OHP and PEGylated TS shRNA-lipoplex: A novel approach to enhance anti-tumor efficacy and reduce the immunogenic response to RNAi molecules,
Journal of Controlled Release, Vol.255, 210-217, 2017.
(DOI: 10.1016/j.jconrel.2017.04.040,   PubMed: 28461099)
88. Mayumi Ikeda, Yu Ishima, Akitomo Shibata, Victor T.G. Chuang, Tomohiro Sawa, Hideshi Ihara, Hiroshi Watanabe, Ming Xian, Yuya Ouchi, Taro Shimizu, Hidenori ANDO, Masami Ukawa, Tatsuhiro Ishida, T Akaike, M Otagiri and T Maruyama :
Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach,
Analytica Chimica Acta, Vol.969, 18-25, 2017.
(DOI: 10.1016/j.aca.2017.03.027,   PubMed: 28411626,   Elsevier: Scopus)
89. Takakuni Matsuda, Shogo Hiraoka, Hiroki Urashima, Ako Ogura and Tatsuhiro Ishida :
Preparation of an ultrafine rebamipide ophthalmic suspension with high transparency,
Biological & Pharmaceutical Bulletin, Vol.40, No.5, 665-674, 2017.
(DOI: 10.1248/bpb.b16-00962,   PubMed: 28458352,   Elsevier: Scopus)
90. Yu Mima, Lila Selim Ahmed Ali Abu Amr, Taro Shimizu, Masami Ukawa, Hidenori ANDO, Yasuko Kurata and Tatsuhiro Ishida :
Ganglioside inserted into PEGylated liposome attenuates anti-PEG immunity,
Journal of Controlled Release, Vol.250, 20-26, 2017.
(DOI: 10.1016/j.jconrel.2017.01.040,   PubMed: 28179196,   Elsevier: Scopus)
91. Yusuke Doi, Lila Selim Ahmed Ali Abu Amr, Haruna Matsumoto, Tomoko Okada, Taro Shimizu and Tatsuhiro Ishida :
Improvement of intratumor microdistribution of PEGylated liposome via tumor priming by metronomic S-1 dosing,
International Journal of Nanomedicine, Vol.11, 5573-5582, 2016.
(Tokushima University Institutional Repository: 115155,   DOI: 10.2147/IJN.S119069,   PubMed: 27822036)
92. Akitomo Shibata, Yu Ishima, Mayumi Ikeda, Hirokazu Sato, Tadashi Imafuku, Victor T. G. Chuang, Yuya Ouchi, Takaya Abe, Hiroshi Watanabe, Tatsuhiro Ishida, Masaki Otagiri and Toru Maruyama :
Human serum albumin hydropersulfide is a potent reactive oxygen species scavenger in oxidative stress conditions such as chronic kidney disease,
Biochemical and Biophysical Research Communications, Vol.479, No.3, 578-583, 2016.
(DOI: 10.1016/j.bbrc.2016.09.113,   PubMed: 27666483,   Elsevier: Scopus)
93. Lila Selim Ahmed Ali Abu Amr, M. Fukushima, C. Huang, H Wada and Tatsuhiro Ishida :
Systemically administered RNAi molecule sensitizes malignant pleural mesothelioma cells to pemetrexed therapy,
Molecular Pharmaceutics, Vol.13, No.11, 3955-3963, 2016.
(Tokushima University Institutional Repository: 115599,   DOI: 10.1021/acs.molpharmaceut.6b00728,   PubMed: 27740765)
94. Takuma Takayama, Masami Ukawa, Yuki Kanazawa, Hidenori ANDO, Taro Shimizu and Tatsuhiro Ishida :
Hydrodynamic tail vein injection as a simple tool for yielding extended transgene expression in solid tumors.,
Biological & Pharmaceutical Bulletin, Vol.39, No.9, 1555-1558, 2016.
(DOI: 10.1248/bpb.b16-00283,   PubMed: 27582335,   Elsevier: Scopus)
95. Y Miwa, H Hamamoto and Tatsuhiro Ishida :
Lidocaine self-sacrificially improves the skin permeation of the acidic and poorly water-soluble drug etodolac via its transformation into an ionic liquid,
European Journal of Pharmaceutics and Biopharmaceutics, Vol.102, 92-100, 2016.
(Tokushima University Institutional Repository: 115101,   DOI: 10.1016/j.ejpb.2016.03.003,   PubMed: 26945484)
96. Lila Selim Ahmed Ali Abu Amr, Chihiro Katoh, M Fukushima, C Huang, H Wada and Tatsuhiro Ishida :
Downregulation of thymidylate synthase by RNAi molecules enhances the antitumor effect of pemetrexed in an orthotopic malignant mesothelioma xenograft mouse model,
International Journal of Oncology, Vol.48, No.4, 1399-1407, 2016.
(DOI: 10.3892/ijo.2016.3367,   PubMed: 26847426)
97. Masami Ukawa, Yukako Fujiwara, Hidenori ANDO, Taro Shimizu and Tatsuhiro Ishida :
Hepatic tumor metastases cause enhanced PEGylated liposome uptake by Kupffer cells,
Biological & Pharmaceutical Bulletin, Vol.39, No.2, 215-220, 2016.
(DOI: 10.1248/bpb.b15-00611,   PubMed: 26830481,   Elsevier: Scopus)
98. Noriko Saito-Tarashima, Hidenori ANDO, Takamitsu Kojima, Nozomi Kinjo, Yosuke Hashimoto, Kazuhiro Furukawa, Tatsuhiro Ishida and Noriaki Minakawa :
Gene silencing using 4'-thioDNA as an artificial template to synthesize short-hairpin RNA without inducing a detectable innate immune response,
Molecular Therapy. Nucleic Acids, Vol.5, e274, 2016.
(Tokushima University Institutional Repository: 110894,   DOI: 10.1038/mtna.2015.48,   PubMed: 26730811,   Elsevier: Scopus)
99. N Eldin Essam, Lila Selim Ahmed Ali Abu Amr, Kazuyoshi Kawazoe, M H Elnahas, A M Mahdy and Tatsuhiro Ishida :
Encapsulation in a rapid-release liposomal formulation enhances the anti-tumor efficacy of pemetrexed in a murine solid mesothelioma-xenograft model,
European Journal of Pharmaceutical Sciences, Vol.81, 60-66, 2016.
(DOI: 10.1016/j.ejps.2015.09.015,   PubMed: 26415830)
100. Hiroyuki Nakamura, Lila Selim Ahmed Ali Abu Amr, Miho Nishio, Masao Tanaka, Hidenori ANDO, Hiroshi Kiwada and Tatsuhiro Ishida :
Intra-tumor distribution of PEGylated liposome upon repeated injection: No possession by prior dose,
Journal of Controlled Release, Vol.220, 406-413, 2015.
(DOI: 10.1016/j.jconrel.2015.11.002,   PubMed: 26548975,   Elsevier: Scopus)
101. Hidenori ANDO, Sakiko Kobayashi, Lila Selim Ahmed Ali Abu Amr, N Eldin Essam, Chihiro Katoh, Taro Shimizu, Masami Ukawa, Kazuyoshi Kawazoe and Tatsuhiro Ishida :
Advanced therapeutic approach for the treatment of malignant pleural mesothelioma via the intrapleural administration of liposomal pemetrexed,
Journal of Controlled Release, Vol.220, 29-36, 2015.
(DOI: 10.1016/j.jconrel.2015.10.019,   PubMed: 26476173,   Elsevier: Scopus)
102. Taro Shimizu, Yu Mima, Yosuke Hashimoto, Masami Ukawa, Hidenori ANDO, Hiroshi Kiwada and Tatsuhiro Ishida :
Anti-PEG IgM and complement system are required for the association of second doses of PEGylated liposomes with splenic marginal zone B cells,
Immunobiology, Vol.220, No.10, 1151-1160, 2015.
(DOI: 10.1016/j.imbio.2015.06.005,   PubMed: 26095176,   Elsevier: Scopus)
103. Munehira Kawanishi, Yosuke Hashimoto, Taro Shimizu, Ikuko Sagawa, Tatsuhiro Ishida and Hiroshi Kiwada :
Comprehensive analysis of PEGylated liposome-asscociated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods,
Biotechnology and Applied Biochemistry, Vol.62, No.4, 547-555, 2015.
(DOI: 10.1002/bab.1291,   PubMed: 25196743,   Elsevier: Scopus)
104. Yu Mima, Yosuke Hashimoto, Taro Shimizu, Hiroshi Kiwada and Tatsuhiro Ishida :
Anti-PEG IgM is a major contributor to the accelerated blood clearance of polyethylene glycol-conjugated protein,
Molecular Pharmaceutics, Vol.12, No.7, 2429-2435, 2015.
(DOI: 10.1021/acs.molpharmaceut.5b00144,   PubMed: 26070445,   Elsevier: Scopus)
105. Noriko Saito-Tarashima, Tatsuya Sumitomo, Hidenori ANDO, Kazuhiro Furukawa, Tatsuhiro Ishida and Noriaki Minakawa :
Synthesis of DNA fragments containing 2-deoxy-4-selenonucleoside units using DNA polymerases: comparison of dNTPs with O, S and Se at the 4-position in replication Org,
Organic & Biomolecular Chemistry, Vol.13, No.25, 6949-6952, 2015.
(DOI: 10.1039/c5ob00941c,   PubMed: 26053864,   Elsevier: Scopus)
106. Yosuke Hashimoto, Taro Shimizu, Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Relationship between the concentration of anti-polyethylene glycol (PEG) in immunoglobulin M (IgM) and the intensity of the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes in mice,
Biological & Pharmaceutical Bulletin, Vol.38, No.3, 417-424, 2015.
(DOI: 10.1248/bpb.b14-00653,   PubMed: 25757923,   CiNii: 1390282679608052736,   Elsevier: Scopus)
107. N Eldin Essam, M H Elnahas, A M Mahdy and Tatsuhiro Ishida :
Liposomal pemetrexed: Formulation, characterization and in vitro cytotoxicity studies for effective management of malignant pleural mesothelioma,
Biological & Pharmaceutical Bulletin, Vol.38, No.3, 461-469, 2015.
(DOI: 10.1248/bpb.b14-00769,   PubMed: 25757929,   Elsevier: Scopus)
108. Takuya Suzuki, Masako Ichihara, Kenji Hyodo, Eiichi Yamamoto, Tatsuhiro Ishida, Hiroshi Kiwada, Hiroshi Kikuchi and Hiroshi Ishihara :
Influence of dose and animal species on accelerated blood clearance of PEGylated liposomal doxorubicin,
International Journal of Pharmaceutics, Vol.476, 205-212, 2014.
(DOI: 10.1016/j.ijpharm.2014.09.047,   PubMed: 25280884,   Elsevier: Scopus)
109. Yota Saito, Yosuke Hashimoto, Mai Arai, Noriko Saito-Tarashima, Tadashi Miyazawa, Kazuya Miki, Mayumi Takahashi, Kazuhiro Furukawa, Naoshi Yamazaki, Akira Matsuda, Tatsuhiro Ishida and Noriaki Minakawa :
Chemistry, properties, and in vitro and in vivo applications of 2'-O-methoxyethyl-4'-thioRNA, a novel hybrid type of chemically modified RNA.,
ChemBioChem, Vol.15, No.17, 2535-2540, 2014.
(DOI: 10.1002/cbic.201402398,   PubMed: 25314258,   Elsevier: Scopus)
110. Yosuke Hashimoto, Lila Selim Ahmed Ali Abu Amr, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
B cell-intrinsic toll-like receptor 7 is responsible for the enhanced anti-PEG IgM production following injection of siRNA-containing PEGylated lipoplex in mice,
Journal of Controlled Release, Vol.184, 1-8, 2014.
(DOI: 10.1016/j.jconrel.2014.04.003,   PubMed: 24727075,   Elsevier: Scopus)
111. Yosuke Hashimoto, Yumi Uehara, Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production,
Gene Therapy, Vol.21, No.6, 593-598, 2014.
(DOI: 10.1038/gt.2014.32,   PubMed: 24694537,   Elsevier: Scopus)
112. Yosuke Hashimoto, Taro Shimizu, Yu Mima, Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs,
Toxicology and Applied Pharmacology, Vol.277, No.1, 30-38, 2014.
(DOI: 10.1016/j.taap.2014.03.002,   PubMed: 24632081,   Elsevier: Scopus)
113. Takako Nakashima, N Sako, Takakuni Matsuda, N Uematsu, K Sakurai and Tatsuhiro Ishida :
Novel Submicronized Rebamipide Liquid with Moderate Viscosity: Significant Effects on Oral Mucositis in Animal Models,
Biological & Pharmaceutical Bulletin, Vol.37, No.4, 671-678, 2014.
(DOI: 10.1248/bpb.b13-01006,   PubMed: 24694614,   Elsevier: Scopus)
114. Hiroyuki Nakamura, Yusuke Doi, Lila Selim Ahmed Ali Abu Amr, Ai Nagao, Tatsuhiro Ishida and Hiroshi Kiwada :
Sequential treatment of oxaliplatin-containing PEGylated liposome together with S-1 improves intratumor distribution of subsequent doses of oxaliplatin-containing PEGylated liposome,
European Journal of Pharmaceutics and Biopharmaceutics, Vol.87, No.1, 142-151, 2014.
(DOI: 10.1016/j.ejpb.2013.12.007,   PubMed: 24361534,   Elsevier: Scopus)
115. Lila Selim Ahmed Ali Abu Amr, Yumi Uehara, Tatsuhiro Ishida and Hiroshi Kiwada :
Application of polyglycerol-coating to pDNA lipoplex for the evasion of the accelerated blood clearance (ABC) phenomenon in nucleic acid delivery.,
Journal of Pharmaceutical Sciences, Vol.103, No.2, 557-566, 2014.
(DOI: 10.1002/jps.23823,   PubMed: 24347396,   Elsevier: Scopus)
116. Lila Selim Ahmed Ali Abu Amr, Masako Ichihara, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Ex-Vivo/In-Vitro Anti-Polyethylene Glycol (PEG) IgM Production From Murine Splenic B Cells Stimulated by PEGylated Liposome,
Biological & Pharmaceutical Bulletin, Vol.36, No.11, 1842-1848, 2013.
(DOI: 10.1248/bpb.b13-00562,   PubMed: 24189428)
117. Takako Nakashima, N Uematsu, M Shibamori, K Sakurai, Tatsuhiro Ishida and Hiroshi Kiwada :
Establishment of an X-ray irradiation-induced glossitis model in rats: biphasic elevation of proinflammatory cytokines and chemokines,
The Journal of Pharmacology and Experimental Therapeutics, Vol.347, No.3, 660-668, 2013.
(DOI: 10.1124/jpet.113.208405,   PubMed: 24060545)
118. Lila Selim Ahmed Ali Abu Amr, Kousuke Nawata, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration,
International Journal of Pharmaceutics, Vol.456, No.1, 235-242, 2013.
(DOI: 10.1016/j.ijpharm.2013.07.059,   PubMed: 23928149)
119. E Alaaeldin, Lila Selim Ahmed Ali Abu Amr, Naoto Moriyoshi, H Sarahan, A Khaled, Tatsuhiro Ishida and Hiroshi Kiwada :
The co-delivery of oxaliplatin abrogates the immunogenic response to PEGylated siRNA-lipoplex.,
Pharmaceutical Research, Vol.30, No.9, 2344-2354, 2013.
(DOI: 10.1007/s11095-013-1078-4,   PubMed: 23673556)
120. Tatsuhiro Ishida and Hiroshi Kiwada :
Development of siRNA Delivery Strategy by Active Control of Tumor Microenvironment,
Journal of the Pharmaceutical Society of Japan, Vol.133, No.3, 379-386, 2013.
(DOI: 10.1248/yakushi.12-00239-5,   CiNii: 1390001206129003136)
121. Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Transport of PEGylated liposomes from the splenic marginal zone to the follicle in the induction phase of the accelerated blood clearance phenomenon.,
Immunobiology, Vol.218, No.5, 725-732, 2013.
(DOI: 10.1016/j.imbio.2012.08.274,   PubMed: 22995937)
122. K Ichikawa, T Asai, K Shimizu, S Yonezawa, T Urakami, H Miyauchi, H Kawashima, Tatsuhiro Ishida, Hiroshi Kiwada and N Oku :
Suppression of immune response by antigen-decorated liposomes encapsulating model agents: A novel strategy for the treatment of allergy.,
Journal of Controlled Release, Vol.167, No.3, 284-289, 2013.
(DOI: 10.1016/j.jconrel.2013.02.002,   PubMed: 23419947)
123. Ai Nagao, Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: Promise for clinical application.,
International Journal of Pharmaceutics, Vol.441, No.1-2, 395-401, 2013.
(DOI: 10.1016/j.ijpharm.2012.11.015,   PubMed: 23174409,   Elsevier: Scopus)
124. Takuya Suzuki, Masako Ichihara, Kenji Hyodo, Eiichi Yamamoto, Tatsuhiro Ishida, Hiroshi Kiwada, Hiroshi Ishihara and Hiroshi Kikuchi :
Accelerated blood clearance of PEGylated liposomes containing doxorubicin upon repeated administration to dogs.,
International Journal of Pharmaceutics, Vol.436, No.1-2, 636-643, 2012.
(DOI: 10.1016/j.ijpharm.2012.07.049,   PubMed: 22850293)
125. Lila Selim Ahmed Ali Abu Amr, N Eldin Essam, Masako Ichihara, Tatsuhiro Ishida and Hiroshi Kiwada :
Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: a possible mechanism and the potential for clinical application.,
International Journal of Pharmaceutics, Vol.438, No.1-2, 176-183, 2012.
(DOI: 10.1016/j.ijpharm.2012.08.030,   PubMed: 22944302)
126. Taro Shimizu, Masako Ichihara, Yasuo Yoshioka, Tatsuhiro Ishida, Shinsaku Nakagawa and Hiroshi Kiwada :
Intravenous administration of polyethylene glycol-coated (PEGylated) proteins and PEGylated adenovirus elicits an anti-PEG immunoglobulin M response.,
Biological & Pharmaceutical Bulletin, Vol.35, No.8, 1336-1342, 2012.
(DOI: 10.1248/bpb.b12-00276,   PubMed: 22863934,   CiNii: 1390001204632293632)
127. Lila Selim Ahmed Ali Abu Amr, Haruna Matsumoto, Yusuke Doi, Hiroyuki Nakamura, Tatsuhiro Ishida, Hiroshi Kiwada and Hiroshi Kiwada :
Tumor type dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin.,
European Journal of Pharmaceutics and Biopharmaceutics, Vol.81, No.3, 524-531, 2012.
(DOI: 10.1016/j.ejpb.2012.04.010,   PubMed: 22554766)
128. Jose Mario Barichello, Shinji Kizuki, Tatsuaki Tagami, Soares Alberto Lira Luiz, Hiroshi Kikuchi, Tatsuhiro Ishida and Hiroshi Kiwada :
Agitation during lipoplex formation harmonizes the interaction of siRNA to cationic liposomes.,
International Journal of Pharmaceutics, Vol.430, No.1-2, 359-365, 2012.
(DOI: 10.1016/j.ijpharm.2012.04.006,   PubMed: 22525078)
129. Tatsuaki Tagami, Lila Selim Ahmed Ali Abu Amr, Mariko Matsunaga, Naoto Moriyoshi, Hiroyuki Nakamura, Kazuya Nakamura, Takuya Suzuki, Yusuke Doi, Tatsuhiro Ishida and Hiroshi Kiwada :
Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model,
Drug Delivery and Translational Research, Vol.2, No.2, 77-86, 2012.
(DOI: 10.1007/s13346-012-0059-1,   Elsevier: Scopus)
130. Lila Selim Ahmed Ali Abu Amr, Tomoko Okada, Yusuke Doi, Masako Ichihara, Tatsuhiro Ishida and Hiroshi Kiwada :
Combination therapy with metronomic S-1 dosing and oxaliplatin-containing PEG-coated cationic liposomes in a murine colorectal tumor model: Synergy or antagonism?,
International Journal of Pharmaceutics, Vol.426, 263-270, 2012.
(DOI: 10.1016/j.ijpharm.2012.01.046,   PubMed: 22310465)
131. Tatsuaki Tagami, Takuya Suzuki, Mariko Matsunaga, Kazuya Nakamura, Naoto Moriyoshi, Tatsuhiro Ishida and Hiroshi Kiwada :
Anti-angiogenic therapy via cationic liposome-mediated systemic siRNA delivery.,
International Journal of Pharmaceutics, Vol.422, No.1-2, 280-289, 2012.
(DOI: 10.1016/j.ijpharm.2011.10.059,   PubMed: 22101286)
132. Kazuya Nakamura, Lila Selim Ahmed Ali Abu Amr, Mariko Matsunaga, Yusuke Doi, Tatsuhiro Ishida and Hiroshi Kiwada :
A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA.,
Molecular Therapy, Vol.19, No.11, 2040-2047, 2011.
(DOI: 10.1038/mt.2011.174,   PubMed: 21878904)
133. Tatsuaki Tagami, Takuya Suzuki, Kiyomi Hirose, Jose Mario Barichello, Naoshi Yamazaki, Tomohiro Asai, Naoto Oku, Tatsuhiro Ishida and Hiroshi Kiwada :
Argonaute2 is a potential target for siRNA-based cancer therapy for HT1080 human fibrosarcoma.,
Drug Delivery and Translational Research, Vol.1, No.4, 277-288, 2011.
(DOI: 10.1007/s13346-011-0025-3)
134. Atsushi Saito, Hiroaki Shimizu, Yusuke Doi, Tatsuhiro Ishida, Miki Fujimura, Takashi Inoue, Hiroshi Kiwada and Teiji Tominaga :
Immunoliposomal drug delivery system targeting lectin-like oxidized low density lipoprotein receptor 1 for carotid plaque lesion in rats.,
Journal of Neurosurgery, Vol.115, No.4, 720-727, 2011.
(DOI: 10.3171/2011.5.JNS10227,   PubMed: 21682565)
135. Jose Mario Barichello, Shinji Kizuki, Tatsuaki Tagami, Tomohiro Asai, Tatsuhiro Ishida, Hiroshi Kikuchi, Naoto Oku and Hiroshi Kiwada :
Agitation during lipoplex formation improves the gene knockdown effect of siRNA.,
International Journal of Pharmaceutics, Vol.410, No.1-2, 153-160, 2011.
(DOI: 10.1016/j.ijpharm.2011.03.001,   PubMed: 21392562)
136. Masako Ichihara, Taro Shimizu, Ami Imoto, Yuki Hashiguchi, Yumi Uehara, Tatsuhiro Ishida and Hiroshi Kiwada :
Anti-PEG IgM response against PEGylated liposomes in mice and rats.,
Pharmaceutics, Vol.3, No.1, 1-11, 2011.
(DOI: 10.3390/pharmaceutics3010001)
137. Tatsuaki Tagami, Yumi Uehara, Naoto Moriyoshi, Tatsuhiro Ishida and Hiroshi Kiwada :
Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA.,
Journal of Controlled Release, Vol.151, No.2, 149-154, 2011.
(DOI: 10.1016/j.jconrel.2010.12.013,   PubMed: 21223988)
138. Yusuke Doi, Tomoko Okada, Haruna Matsumoto, Masako Ichihara, Tatsuhiro Ishida and Hiroshi Kiwada :
Combination therapy of metronomic S-1 dosing with oxaliplatin-containing PEG-coated liposome improves antitumor activity in a murine colorectal tumor model.,
Cancer Science, Vol.101, No.11, 2470-2475, 2010.
(DOI: 10.1111/j.1349-7006.2010.01678.x,   PubMed: 20731663)
139. T Ishihara, T Maeda, H Sakamoto, N Takasaki, M Shigyo, Tatsuhiro Ishida, Hiroshi Kiwada, Y Mizushima and T Mizushima :
Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers.,
Biomacromolecules, Vol.11, No.10, 2700-2706, 2010.
(DOI: 10.1021/bm100754e,   PubMed: 20795699)
140. Y Eto, Y Yoshioka, Tatsuhiro Ishida, X Yao, T Morishige, S Narimatsu, H Mizuguchi, Y Mukai, N Okada, Hiroshi Kiwada and S Nakagawa :
Optimized PEGylated adenovirus vector reduces the anti-vector humoral immune response against adenovirus and induces a therapeutic effect against metastatic lung cancer.,
Biological & Pharmaceutical Bulletin, Vol.33, No.9, 1540-1544, 2010.
(DOI: 10.1248/bpb.33.1540,   PubMed: 20823571)
141. Hiroyuki Yamazaki, Masateru Miyake, Naoki Kamada, Toru Nishibayashi, Tadashi Mukai, Masaaki Odomi, Tatsuhiro Ishida and Hiroshi Kiwada :
Co-administration of tacrolimus suppresses pharmacokinetic modulation of multiple subcutaneously administrated human interferon-alpha in beagle dogs.,
Drug Metabolism and Pharmacokinetics, Vol.25, No.2, 149-154, 2010.
(DOI: 10.2133/dmpk.25.149,   PubMed: 20460820)
142. H Koide, T Asai, K Hatanaka, S Akai, T Ishii, E Kenjo, Tatsuhiro Ishida, Hiroshi Kiwada, H Tsukada and N Oku :
T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.,
International Journal of Pharmaceutics, Vol.392, No.1-2, 218-223, 2010.
(DOI: 10.1016/j.ijpharm.2010.03.022,   PubMed: 20227473)
143. Tatsuaki Tagami, Kazuya Nakamura, Taro Shimizu, Naoshi Yamazaki, Tatsuhiro Ishida and Hiroshi Kiwada :
CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes.,
Journal of Controlled Release, Vol.142, No.2, 160-166, 2010.
(DOI: 10.1016/j.jconrel.2009.10.017,   PubMed: 19850094)
144. Lila Selim Ahmed Ali Abu Amr, Yusuke Doi, Kazuya Nakamura, Tatsuhiro Ishida and Hiroshi Kiwada :
Sequential administration with oxaliplatin-containing PEG-coated cationic liposomes promotes a significant delivery of subsequent dose into murine solid tumor.,
Journal of Controlled Release, Vol.142, No.2, 167-173, 2010.
(DOI: 10.1016/j.jconrel.2009.10.020,   PubMed: 19861140)
145. Tsutomu Ishihara, Miho Takeda, Haruka Sakamoto, Ayumi Kimoto, Chisa Kobayashi, Naoko Takasaki, Kanae Yuki, Ken-ichiro Tanaka, Mitsuko Takenaga, Rie Igarashi, Taishi Maeda, Naoki Yamakawa, Yoshinari Okamoto, Masami Otsuka, Tatsuhiro Ishida, Hiroshi Kiwada, Yutaka Mizushima and Tohru Mizushima :
Accelerated blood clearance phenomenon upon repeated injection of PEG-modified PLA-nanoparticles.,
Pharmaceutical Research, Vol.26, No.10, 2270-2279, 2009.
(DOI: 10.1007/s11095-009-9943-x,   PubMed: 19633820)
146. Hiroyuki Yamazaki, Masateru Miyake, Toru Nishibayashi, Tadashi Mukai, Masaaki Odomi, Tatsuhiro Ishida and Hiroshi Kiwada :
Effect of co-administration of tacrolimus on the pharmacokinetics of multiple subcutaneous administered interferon-alpha in rats.,
Pharmaceutical Research, Vol.26, No.8, 1832-1837, 2009.
(DOI: 10.1007/s11095-009-9892-4,   PubMed: 19415469)
147. Tatsuaki Tagami, Kazuya Nakamura, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Effect of siRNA in PEG-coated siRNA-lipoplex on the anti-PEG IgM production.,
Journal of Controlled Release, Vol.137, No.3, 234-240, 2009.
(DOI: 10.1016/j.jconrel.2009.04.006,   PubMed: 19361546)
148. Tatsuhiro Ishida, Emi Shiraga and Hiroshi Kiwada :
Synergistic antitumor activity of metronomic dosing of cyclophosphamide in combination with doxorubicin-containing PEGylated liposomes in a murine solid tumor model.,
Journal of Controlled Release, Vol.134, No.3, 194-200, 2009.
(DOI: 10.1016/j.jconrel.2008.11.019,   PubMed: 19095022)
149. Lila Selim Ahmed Ali Abu Amr, Shinji Kizuki, Yusuke Doi, Takuya Suzuki, Tatsuhiro Ishida and Hiroshi Kiwada :
Oxaliplatin encapsulated in PEG-coated cationic liposomes induces significant tumor growth suppression via a dual-targeting approach in a murine solid tumor model.,
Journal of Controlled Release, Vol.137, No.1, 8-14, 2009.
(DOI: 10.1016/j.jconrel.2009.02.023,   PubMed: 19285528)
150. Yoshimasa Isakari, Shinji Sogo, Tatsuhiro Ishida, Takuma Kawakami, Toshihide Ono, Takao Taki and Hiroshi Kiwada :
Gene expression analysis during platelet-like particle production in phorbol myristate acetate-treated MEG-01 cells.,
Biological & Pharmaceutical Bulletin, Vol.32, No.3, 354-358, 2009.
(DOI: 10.1248/bpb.32.354,   PubMed: 19252277)
151. Lila Selim Ahmed Ali Abu Amr, Takuya Suzuki, Yusuke Doi, Tatsuhiro Ishida and Hiroshi Kiwada :
Oxaliplatin targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model.,
Journal of Controlled Release, Vol.134, No.1, 18-25, 2009.
(DOI: 10.1016/j.jconrel.2008.10.018,   PubMed: 19010364)
152. Tatsuaki Tagami, Kiyomi Hirose, Jose Mario Barichello, Tatsuhiro Ishida and Hiroshi Kiwada :
Global gene expression profiling in cultured cells is strongly influenced by treatment with siRNA-cationic liposome complexes.,
Pharmaceutical Research, Vol.25, No.11, 2497-2504, 2008.
(DOI: 10.1007/s11095-008-9663-7,   PubMed: 18581204)
153. Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Takeo Urakami, Takayuki Ishii, Eriya Kenjo, Masamichi Nishihara, Masayuki Yokoyama, Tatsuhiro Ishida, Hiroshi Kiwada and Naoto Oku :
Particle size-dependent triggering of accelerated blood clearance phenomenon.,
International Journal of Pharmaceutics, Vol.362, No.1-2, 197-200, 2008.
(DOI: 10.1016/j.ijpharm.2008.06.004,   PubMed: 18586076)
154. Emi Shiraga, Jose Mario Barichello, Tatsuhiro Ishida and Hiroshi Kiwada :
A metronomic schedule of cyclophosphamide combined with PEGylated liposomal doxorubicin has a highly antitumor effect in an experimental pulmonary metastatic mouse model.,
International Journal of Pharmaceutics, Vol.353, No.1-2, 65-73, 2008.
(DOI: 10.1016/j.ijpharm.2007.11.020,   PubMed: 18155369)
155. Kuniko Matsumura-Takeda, Tatsuhiro Ishida, Shinji Sogo, Yoshimasa Isakari, Takao Taki, Toshiki Sudo and Hiroshi Kiwada :
Lactoferrin inhibits platelet production from human megakaryocytes in vitro.,
Biological & Pharmaceutical Bulletin, Vol.31, No.4, 569-573, 2008.
(DOI: 10.1248/bpb.31.569,   PubMed: 18379042)
156. Tatsuhiro Ishida, Shuntarou Kashima and Hiroshi Kiwada :
The contribution of phagocytic activity of liver macrophages to the accelerated blood clearance (ABC) phenomenon of PEGylated liposomes in rats.,
Journal of Controlled Release, Vol.126, No.2, 162-165, 2008.
(DOI: 10.1016/j.jconrel.2007.11.009,   PubMed: 18160170)
157. Mario José Barichello, Noriko Yamakawa, Masatoshi Kisyuku, Hiroshi Handa, Taiki Shibata, Tatsuhiro Ishida and Hiroshi Kiwada :
Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.,
International Journal of Pharmaceutics, Vol.357, No.1-2, 199-205, 2008.
(DOI: 10.1016/j.ijpharm.2008.01.052,   PubMed: 18343610)
158. T Asai, Y Suzuki, S Matsushita, S Yonezawa, J Yokota, Y Katanasaka, Tatsuhiro Ishida, T Dewa, Hiroshi Kiwada, N Nango and N Oku :
Disappearance of the angiogenic potential of endothelial cells caused by Argonaute2 knockdown.,
Biochemical and Biophysical Research Communications, Vol.368, No.2, 243-248, 2008.
(DOI: 10.1016/j.bbrc.2008.01.074,   PubMed: 18222171)
159. Tatsuhiro Ishida, Wang Xinyu, Taro Shimizu, Kousuke Nawata and Hiroshi Kiwada :
PEGylated liposomes elicit an anti-PEG IgM response in a T-cells independent manner.,
Journal of Controlled Release, Vol.122, No.3, 349-355, 2007.
(DOI: 10.1016/j.jconrel.2007.05.015,   PubMed: 17610982)
160. Hiroto Hatakeyama, Hidetaka Akita, Emi Ishida, Koichi Hashimoto, Hideo Kobayashi, Takanori Aoki, Junko Yasuda, Kenichi Obata, Hiroshi Kikuchi, Tatsuhiro Ishida, Hiroshi Kiwada and Hideyoshi Harashima :
Tumor targeting of doxorubicin by anti MT1-MMP antibody-modified PEG liposomes.,
International Journal of Pharmaceutics, Vol.342, No.1-2, 194-200, 2007.
(DOI: 10.1016/j.ijpharm.2007.04.037,   PubMed: 17583453)
161. Kazutaka Atobe, Tatsuhiro Ishida, Emi Ishida, Kouichi Hashimoto, Hideo Kobayashi, Jyunko Yasuda, Takanori Aoki, Ken-ichi Obata, Hiroshi Kikuchi, Hidetaka Akita, Tomohiro Asai, Hideyoshi Harashima, Naoto Oku and Hiroshi Kiwada :
In vitro efficacy of a sterically stabilized immunoliposomes targeted to membrane type 1 matrix metalloproteinase (MT1-MMP).,
Biological & Pharmaceutical Bulletin, Vol.30, No.5, 972-978, 2007.
(DOI: 10.1248/bpb.30.972,   PubMed: 17473445)
162. Lap Thi Nguen, Kazutaka Atobe, Mari Jose Barichello, Tatsuhiro Ishida and Hiroshi Kiwada :
Complex formation with plasmid DNA increases the cytotoxicity of cationic liposomes.,
Biological & Pharmaceutical Bulletin, Vol.30, No.4, 751-757, 2007.
(DOI: 10.1248/bpb.30.751,   PubMed: 17409515)
163. Tatsuaki Tagami, Mari Jose Barichello, Hiroshi Kikuchi, Tatsuhiro Ishida and Hiroshi Kiwada :
The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex.,
International Journal of Pharmaceutics, Vol.333, No.1-2, 62-69, 2007.
(DOI: 10.1016/j.ijpharm.2006.09.057,   PubMed: 17097247)
164. Xinyu Wang, Tatsuhiro Ishida and Hiroshi Kiwada :
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.,
Journal of Controlled Release, Vol.119, No.2, 236-244, 2007.
(DOI: 10.1016/j.jconrel.2007.02.010,   PubMed: 17399838)
165. Yoshimasa Isakari, Yasuo Harada, Dai Ishikawa, Kuniko Matsumura-Takeda, Shinji Sogo, Tatsuhiro Ishida, Takao Taki and Hiroshi Kiwada :
Efficient gene expression in Megakaryocytic cell line using Nucleofection.,
International Journal of Pharmaceutics, Vol.338, No.1-2, 157-164, 2007.
(DOI: 10.1016/j.ijpharm.2007.01.042,   PubMed: 17331684)
166. Tomotaka Kobayashi, Tatsuhiro Ishida, Yurie Okada, Saori Ise, Hideyoshi Harashima and Hiroshi Kiwada :
Effect of Transferrin receptor-targeted liposomal doxorubicin in P-glycoprotein-mediated drug resistant tumor cells.,
International Journal of Pharmaceutics, Vol.329, No.1-2, 94-102, 2007.
(DOI: 10.1016/j.ijpharm.2006.08.039,   PubMed: 16997518)
167. Tatsuhiro Ishida, Kazutaka Atobe, Xinyu Wang and Hiroshi Kiwada :
Accelerated blood clearance of PEGylated liposomes upon repeated injections: Effect of doxorubicin-encapsulation and high-dose first injection.,
Journal of Controlled Release, Vol.115, No.3, 251-258, 2006.
(DOI: 10.1016/j.jconrel.2006.08.017,   PubMed: 17045355)
168. Tatsuhiro Ishida, Masako Ichihara, Xinyu Wang and Hiroshi Kiwada :
Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.,
Journal of Controlled Release, Vol.115, No.3, 243-250, 2006.
(DOI: 10.1016/j.jconrel.2006.08.001,   PubMed: 17011060)
169. Mario Jose Barichello, M. Handa, M. Kisyuku, Taiki Shibata, Tatsuhiro Ishida and Hiroshi Kiwada :
Inducing effect of liposomalization on the transdermal delivery of hydrocortisone: creation of a drug supersaturated state.,
Journal of Controlled Release, Vol.115, No.1, 94-102, 2006.
(DOI: 10.1016/j.jconrel.2006.07.008,   PubMed: 16919352)
170. Foi Dang, Wenhao Li, LiGo Zhang, M Japasini, Tatsuhiro Ishida, Hiroshi Kiwada, N. Kaji, M. Tokeshi and Yoshinobu Baba :
Electrophoretic behavior of plasmid DNA in the presence of various intercalating dyes.,
Journal of Chromatography. A, Vol.1118, No.2, 218-225, 2006.
(DOI: 10.1016/j.chroma.2006.03.120,   PubMed: 16643931)
171. Tatsuhiro Ishida, Masako Ichihara, Xinyu Wang, Kenji Yamamoto, Jyunji Kimura, Eiji Majima and Hiroshi Kiwada :
Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.,
Journal of Controlled Release, Vol.112, No.1, 15-25, 2006.
(DOI: 10.1016/j.jconrel.2006.01.005,   PubMed: 16515818)
172. Tatsuhiro Ishida, Wenhao Liu, Zhung Li and Hiroshi Kiwada :
Stimulatory effect of polyethylene glycol (PEG) on gene expression in mouse liver following hydrodynamics-based transfection.,
The Journal of Gene Medicine, Vol.8, No.3, 324-334, 2006.
(DOI: 10.1002/jgm.850,   PubMed: 16288498)
173. Tatsuhiro Ishida, Yurie Okada, Tomotaka Kobayashi and Hiroshi Kiwada :
Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood.,
International Journal of Pharmaceutics, Vol.309, No.1-2, 94-100, 2006.
(DOI: 10.1016/j.ijpharm.2005.11.010,   PubMed: 16364578,   Elsevier: Scopus)
174. Lap Thi Nguyen, Tatsuhiro Ishida and Hiroshi Kiwada :
Gene Expression in Primary Cultured Mouse Hepatocytes with a Cationic Liposomal Vector, TFL-3: Comparison with Rat Hepatocytes,
Biological & Pharmaceutical Bulletin, Vol.28, No.8, 1472-1475, 2005.
(DOI: 10.1248/bpb.28.1472,   PubMed: 16079495)
175. Tatsuhiro Ishida, Masae Harada, Wang Xinyu, Masako Ichihara, Kenji Irimura and Hiroshi Kiwada :
Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: Effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes,
Journal of Controlled Release, Vol.105, No.3, 305-317, 2005.
(DOI: 10.1016/j.jconrel.2005.04.003,   PubMed: 15908032)
176. Wang Xinyu, Tatsuhiro Ishida, Masako Ichihara and Hiroshi Kiwada :
Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rat,
Journal of Controlled Release, Vol.104, No.1, 91-102, 2005.
(DOI: 10.1016/j.jconrel.2005.01.008,   PubMed: 15866337)
177. Koichiro Tsuchiya, Yasuhisa Kanematsu, Masanori Yoshizumi, Hideki Ohnishi, Kazuyoshi Kirima, Yuki Izawa, Michiyo Shikishima, Tatsuhiro Ishida, Shuji Kondo, Shoji Kagami, Yoshiharu Takiguchi and Toshiaki Tamaki :
Nitrite is an alternative source of NO in vivo,
American Journal of Physiology, Heart and Circulatory Physiology, Vol.288, No.5, H2163-H2170, 2005.
(DOI: 10.1152/ajpheart.00525.2004,   PubMed: 15626692)
178. Wenhao Li, Tatsuhiro Ishida, Yurie Okada, Naoto Oku and Hiroshi Kiwada :
Increased Gene Expression by Cationic Liposomes (TFL-3) in Lung Metastases Following Intravenous Injection,
Biological & Pharmaceutical Bulletin, Vol.28, No.4, 701-706, 2005.
(DOI: 10.1248/bpb.28.701,   PubMed: 15802813)
179. Wenhao Li, Tatsuhiro Ishida, Rieko Tachibana, Mohamad Radwan Almofti, Xinyu Wang and Hiroshi Kiwada :
Cell type-specific gene expression, mediated by TFL-3, a cationic liposomal vector, is controlled by a post-transcription process of delivered plasmid DNA,
International Journal of Pharmaceutics, Vol.276, No.1-2, 67-74, 2004.
(DOI: 10.1016/j.ijpharm.2004.02.011,   PubMed: 15113615)
180. Tatsuhiro Ishida, Takako Ichikawa, Masako Ichihara, Yasuyuki Sadzuka and Hiroshi Kiwada :
Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice.,
Journal of Controlled Release, Vol.95, No.3, 403-412, 2004.
(DOI: 10.1016/j.jconrel.2003.12.011,   PubMed: 15023452)
181. Lap Thi Nguyen, Tatsuhiro Ishida, Sachiko Ukitsu, Wen Hao Li, Rieko Tachibana and Hiroshi Kiwada :
Culture Time-Dependent Gene Expression in Isolated Primary Cultured Rat Hepatocytes by Transfection with the Cationic Liposomal Vector TFL-3,
Biological & Pharmaceutical Bulletin, Vol.26, No.6, 880-885, 2003.
(DOI: 10.1248/bpb.26.880,   PubMed: 12808305,   CiNii: 1390282679603298048)
182. Tatsuhiro Ishida, Kaori Masuda, Takako Ichikawa, Masako Ichihara, Kenji Irimura and Hiroshi Kiwada :
Accelerated clearance of a second injection of PEGylated liposomes in mice.,
International Journal of Pharmaceutics, Vol.255, No.1-2, 167-174, 2003.
(DOI: 10.1016/S0378-5173(03)00085-1,   PubMed: 12672612)
183. Tatsuhiro Ishida, Ryuhei Maeda, Masako Ichihara, Kenji Irimura and Hiroshi Kiwada :
Accelerated clearance of PEGylated liposomes in rats after repeated injections.,
Journal of Controlled Release, Vol.88, No.1, 35-42, 2003.
(DOI: 10.1016/S0168-3659(02)00462-5,   PubMed: 12586501)
184. Sayaka Yamamoto, Tatsuhiro Ishida, Akiko Inoue, Junko Mikami, Masahiro Muraguchi, Yasukazu Ohmoto and Hiroshi Kiwada :
HEPC-based liposomes trigger cytokine release from peripheral blood cells: effects of liposomal size, dose and lipid composition,
International Journal of Pharmaceutics, Vol.236, No.1-2, 125-133, 2002.
(DOI: 10.1016/S0378-5173(02)00026-1,   PubMed: 11891076)
185. Rieko Tachibana, Hideyoshi Harashima, Tatsuhiro Ishida, Yasuo Shinohara, Mari Hino, Hiroshi Terada, Yoshinobu Baba and Hiroshi Kiwada :
Effect of Cationic Liposomes in an in Vitro Transcription and Translation System,
Biological & Pharmaceutical Bulletin, Vol.25, No.4, 529-531, 2002.
(DOI: 10.1248/bpb.25.529,   PubMed: 11995939)
186. João N. Moreira, Tatsuhiro Ishida, Rogério Gaspar and Theresa M. Allen :
Use of the post-insertion technique to insert peptide ligands into pre-formed Stealth liposomes with retention of binding activity and cytotoxicity,
Pharmaceutical Research, Vol.19, No.3, 265-269, 2002.
(DOI: 10.1023/A:1014434732752,   PubMed: 11934232)
187. Tatsuhiro Ishida, Yoshihiro Takanashi, Hisako Doi, Isao Yamamoto and Hiroshi Kiwada :
Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stabiliy of the fasudil-loaded liposomes gradient.,
International Journal of Pharmaceutics, Vol.232, No.1-2, 59-67, 2002.
(DOI: 10.1016/S0378-5173(01)00896-1,   PubMed: 11790490,   CiNii: 1570291226801262464)
188. 高梨 吉裕, Tatsuhiro Ishida, 目黒 俊成, J Zhang and 山本 勇夫 :
くも膜下出血後の脳血管簾縮に対する髄液内投与可能な徐放性塩酸ファスジル(エリル)の開発,
Surgery for Cerebral Stroke, Vol.30, 133-136, 2002.
189. Tatsuhiro Ishida, M.J. Kirchmeier, E.H. Moase, S. Zalipsky and T.M. Allen :
Targeted delivery and triggered release of liposomal doxorubicin (DXR) enhances cytotoxicity against human B-cell lymphoma cells.,
Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1515, No.2, 144-158, 2001.
(DOI: 10.1016/S0005-2736(01)00409-6,   PubMed: 11718670)
190. Yoshihiro Takanashi, Tatsuhiro Ishida, Toshinari Meguro, Marc J. Kirchmeier, Theresa M. Allen and John H. Zhang :
Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats,
Journal of Clinical Neuroscience, Vol.8, No.6, 557-561, 2001.
(DOI: 10.1054/jocn.2001.0998)
191. Tatsuhiro Ishida, Kazumi Yasukawa, Hiroko Kojima, Hideyoshi Harashima and Hiroshi Kiwada :
Effect of cholesterol content in activation of the classical versus the alternative pathway of rat complement system induced by hydrogenated egg phosphatidylcholine-based liposomes,
International Journal of Pharmaceutics, Vol.224, No.1-2, 69-79, 2001.
(DOI: 10.1016/S0378-5173(01)00737-2,   PubMed: 11472816)
192. Tran Minh Huong, Tatsuhiro Ishida, Hideyoshi Harashima and Hiroshi Kiwada :
Species Difference in Correlation between in Vivo/ in Vitro LiposomeComplement Interactions,
Biological & Pharmaceutical Bulletin, Vol.24, No.4, 439-441, 2001.
(DOI: 10.1248/bpb.24.439,   PubMed: 11305612)
193. Yoshihiro Takanashi, Tatsuhiro Ishida, Toshinari Meguro, Hiroshi Kiwada, John H Zhang and Isao Yamamoto :
Efficacy of Intrathecal Liposomal Fasudil for Experimental Cerebral Vasospasm after Subarachnoid Hemorrhage,
Neurosurgery, Vol.48, No.4, 894-901, 2001.
(DOI: 10.1097/00006123-200104000-00041,   PubMed: 11322450)
194. Tran Minh Huong, Tatsuhiro Ishida, Hideyoshi Harashima and Hiroshi Kiwada :
The complement system enhances the clearance of phosphatidylserine (PS)-liposomes in rat and guinea pig,
International Journal of Pharmaceutics, Vol.215, No.1-2, 197-205, 2001.
(DOI: 10.1016/S0378-5173(00)00691-8,   PubMed: 11250105,   Elsevier: Scopus)
195. Yoshihiro Takanashi, Tatsuhiro Ishida, Marc J. Kirchmeier, Ashfaq Shuaib and Theresa M. Alien :
Neuroprotection by intrathecal application of liposome-entrapped Fasudil in a rat model of ischemia,
Neurologia Medico-Chirurgica, Vol.41, No.3, 107-114, 2001.
(DOI: 10.2176/nmc.41.107,   PubMed: 11372552)
196. Marc J. Kirchmeier, Tatsuhiro Ishida, Julie Chevrette and Theresa M. Allen :
Correlations between the rate of intracellular release of endocytosed liposomal doxorubicin and cytotoxicity as determined by a new assay,
Journal of Liposome Research, Vol.11, No.1, 15-29, 2001.
(DOI: 10.1081/LPR-100103167,   PubMed: 19530916,   Elsevier: Scopus)
197. H E Moase, W Qi, Tatsuhiro Ishida, Z Gabos, M B Longenecker, L G Zimmermann, L Ding, M Krantz and M T Allen :
Anti-MUC-1 immunoliposomal doxorubicin in the treatment of murine models of metastatic breast cancer,
Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol.1510, No.1-2, 43-55, 2001.
(DOI: 10.1016/S0005-2736(00)00334-5,   PubMed: 11342146)
198. Tatsuhiro Ishida, Hiroko Kojima, Hideyoshi Harashima and Hiroshi Kiwada :
Biodistribution of liposomes and C3 fragments associated with liposomes:evaluation of their relationship,
International Journal of Pharmaceutics, Vol.205, No.1-2, 183-193, 2000.
(DOI: 10.1016/S0378-5173(00)00511-1,   PubMed: 11000555)
199. Tatsuhiro Ishida, Dbbie L. Iden and Theresa M. Allen :
A combinatorial approach to producing sterically stabilized(Stealth)immunoliposomal drugs,
FEBS Letters, Vol.460, No.1, 129-133, 1999.
(DOI: 10.1016/S0014-5793(99)01320-4)
200. Tatsuhiro Ishida, Shinya Iida, Kouichi Funato and Hiroshi Kiwada :
A novel plasma factor initiating complement activation on cetylmannoside-modified liposomes in human plasma,
International Journal of Pharmaceutics, Vol.164, No.1-2, 91-102, 1998.
(DOI: 10.1016/S0378-5173(97)00403-1)
201. Shicheng Liu, Tatsuhiro Ishida and Hiroshi Kiwada :
Characterization of Bovine Serum Factor Triggering the Lysis of Liposomes via Complement Activation,
Biological & Pharmaceutical Bulletin, Vol.21, No.4, 390-397, 1998.
(DOI: 10.1248/bpb.21.390)
202. 小島 弘子, Tatsuhiro Ishida, 原島 秀吉 and Hiroshi Kiwada :
リポソーム膜中のコレステロール含量が及ぼす補体第3成分(C3)の結合と体内動態への影響,
Drug Delivery System, Vol.13, 55-61, 1998.
203. Tatsuhiro Ishida, Kouichi Funato, Shigeo Kojima, Ritsuko Yoda and Hiroshi Kiwada :
Enhancing effect of cholesterol on the elimination of liposomes from circulation is mediated by complement activation,
International Journal of Pharmaceutics, Vol.156, No.1, 27-37, 1997.
(DOI: 10.1016/S0378-5173(97)00174-9)
204. S Liu, Tatsuhiro Ishida and Hiroshi Kiwada :
Effect of Serum Components from Different Species on Destabilizing Hydrogenated Phosphatidylcholine-Based Liposomes,
Biological & Pharmaceutical Bulletin, Vol.20, No.8, 874-880, 1997.
(DOI: 10.1248/bpb.20.874)
205. Tatsuhiro Ishida, 篠原 美加 and Hiroshi Kiwada :
セチルマンノシド修飾リポソームへのC3フラグメントの結合における粒子径の影響,
Drug Delivery System, Vol.12, No.3, 155-160, 1997.
(DOI: 10.2745/dds.12.155)
206. H Harashima, T M Huong, Tatsuhiro Ishida, Y Manabe, H Matsuo and Hiroshi Kiwada :
Synergistic Effect Between Size and Cholesterol Content in the Enhanced Hepatic Uptake Clearance of Liposomes Through Complement Activation in Rats,
Pharmaceutical Research, Vol.13, No.11, 1704-1709, 1996.
(DOI: 10.1023/A:1016401025747)
207. AJ Ferdous, Tatsuhiro Ishida, M Shinohara, H Harashima and Hiroshi Kiwada :
Size-dependent release of carboxyfluorescein from cetylmannoside-modifide liposomes in human plasma,
Biopharmaceutics & Drug Disposition, Vol.17, No.2, 145-154, 1996.
(DOI: 10.1002/(SICI)1099-081X(199603)17:2<145::AID-BDD942>3.0.CO;2-Y)
208. Tatsuhiro Ishida, 篠原 美加, 岩田 房子, 大本 安一 and Hiroshi Kiwada :
抗ヒトC3モノクローナル抗体を用いたリポソーム表面上のC3フラグメント定量,
Drug Delivery System, Vol.9, 25-30, 1994.
(DOI: 10.2745/dds.9.25,   Elsevier: Scopus)

Academic Paper (Unrefereed Paper):

1. Hideyoshi Harashima and Tatsuhiro Ishida :
Editorial: Advanced Liposome Research,
Advanced Drug Delivery Reviews, Vol.154-155, 1, 2020.
(DOI: 10.1016/j.addr.2020.10.013)

Review, Commentary:

1. A Sherif Gaballa, Taro Shimizu, Hidenori ANDO, Haruka Takata, Sherif Abdallah Emam Emam, Eslam Mostafa Ramadan Abdelhameed, W Youssef Naguib, M Fatma Mady, A Khaled Khaled and Tatsuhiro Ishida :
Treatment-induced and pre-existing anti-PEG antibodies: Prevalence, clinical implications, and future perspectives,
Journal of Pharmaceutical Sciences, Vol.113, No.3, 555-578, Mar. 2024.
(DOI: 10.1016/j.xphs.2023.11.001)
2. Mayumi Ikeda, Tatsuya Fukuta, 岩尾 康範, 小田切 優樹, 丸山 徹, Tatsuhiro Ishida and Yu Ishima :
血清アルブミンに存在する超硫黄の解析と創薬応用,
Journal of the Pharmaceutical Society of Japan, Vol.144, No.1, 51-56, Jan. 2024.
(DOI: 10.1248/yakushi.23-00162-3)
3. Taro Shimizu, 濱本 英利 and Tatsuhiro Ishida :
イオン液体を利用した外用剤・経皮吸収製剤の開発と疾患治療への応用,
Drug Delivery System, Vol.38, No.3, 230-238, Jul. 2023.
(DOI: 10.2745/dds.38.230)
4. Ibrahim Mohamed, Eslam Mostafa Ramadan Abdelhameed, Nehal Ali Emam Elsadek Emam Elhewan, Sherif Abdallah Emam Emam, Taro Shimizu, Hidenori ANDO, Yu Ishima, Elgarhy Helmy Omar, Sarhan A Hatem, Hussein K Amal and Tatsuhiro Ishida :
Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products,
Journal of Controlled Release, Vol.351, 215-230, Nov. 2022.
(DOI: 10.1016/j.jconrel.2022.09.031)
5. Nana Matsuo, Hidenori ANDO, Yusuke Doi, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
The challenge to deliver oxaliplatin (l-OHP) to solid tumors: development of liposomal l-OHP formulations,
Chemical & Pharmaceutical Bulletin, Vol.70, No.5, 351-358, May 2022.
(DOI: 10.1248/cpb.c22-00099)
6. Yu Ishima, Toru Maruyama, Masaki Otagiri, G Victor T Chuang and Tatsuhiro Ishida :
The new delivery strategy of albumin carrier utilizing the interaction with albumin receptors,
Chemical & Pharmaceutical Bulletin, Vol.70, No.5, 330-333, May 2022.
(DOI: 10.1248/cpb.c21-01024)
7. Giuseppe Curigliano, 松村 保広 and Tatsuhiro Ishida :
最新の免疫腫瘍微小環境の理解とADC,DDSの革新的イノベーション,
がん分子標的治療, Vol.19, No.2, 47-55, Jan. 2022.
8. Hidenori ANDO and Tatsuhiro Ishida :
An RNAi therapeutic, DFP-10825, for intraperitoneal and intrapleural malignant cancers,
Advanced Drug Delivery Reviews, Vol.154-155, 27-36, Aug. 2020.
(DOI: 10.1016/j.addr.2020.08.002,   PubMed: 32781056)
9. G Kozma, Taro Shimizu, Tatsuhiro Ishida and J Szebeni :
Anti-PEG antibodies: Properties, formation and role in adverse immune reactions to PEGylated nano-biopharmaceuticals,
Advanced Drug Delivery Reviews, Vol.154-155, 163-175, Aug. 2020.
(Tokushima University Institutional Repository: 116267,   DOI: 10.1016/j.addr.2020.07.024)
10. Yu Ishima, Toru Maruyama, Masaki Otagiri and Tatsuhiro Ishida :
Drug Delivery System for Refractory Cancer Therapy via an Endogenous Albumin Transport System,
Chemical & Pharmaceutical Bulletin, Vol.68, No.7, 583-588, Jul. 2020.
(DOI: 10.1248/cpb.c20-00026)
11. Tatsuhiro Ishida, Shigeru Kawakami and Ken-ichi Hosoya :
Foreward in Recent advances in research on particulate formulations such as lipoproteins, liposomes, extracellular vesicles, and iPS-derived cells,
Biological & Pharmaceutical Bulletin, Vol.43, No.4, 575, Apr. 2020.
(DOI: 10.1248/bpb.b20-ctf4304)
12. Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
タンパクのPEG修飾によるPEG免疫応答の誘導,
Journal of the Pharmaceutical Society of Japan, Vol.140, No.2, 163-169, Feb. 2020.
(DOI: 10.1248/yakushi.19-00187-5)
13. Hidenori ANDO and Tatsuhiro Ishida :
臨床応用可能な体腔内投与型RNAi 製剤(DFP-10825)の開発と難治性がんに対する治療,
MEDCHEM NEWS, Vol.30, No.1, 19-24, Feb. 2020.
(DOI: 10.14894/medchem.30.1_19)
14. Hidenori ANDO, Taro Shimizu and Tatsuhiro Ishida :
リポソームDDS 製剤開発における免疫系の制御と動態解析の重要性,
Oleoscience, Vol.20, No.2, 71-76, Feb. 2020.
(DOI: 10.5650/oleoscience.20.71,   CiNii: 1390283659849385728)
15. Hidenori ANDO, 田島 健次, 松島 得雄 and Tatsuhiro Ishida :
ナノフィブリル化バクテリアセルロース(Fibnano)を用いた腹腔内投与型がん治療製剤への応用,
Cellulose Communications, Vol.26, No.4, 173-177, Dec. 2019.
16. 田島 健次, 小瀬 亮太, 松島 得雄, Tatsuhiro Ishida and Hidenori ANDO :
フルーツ由来新奇酢酸菌によるナノセルロースの合成とその応用,
Journal of The Brewing Society of Japan, Vol.114, No.9, 540-549, Sep. 2019.
(CiNii: 1050287462784741632)
17. M Mohamed, Lila Selim Ahmed Ali Abu Amr, Taro Shimizu, E Alaaeldin, A Hussein, H Sarhan, J Szebeni and Tatsuhiro Ishida :
PEGylated liposomes: immunological responses,
Science and Technology of Advanced Materials, Vol.20, No.1, 710-724, Jun. 2019.
(Tokushima University Institutional Repository: 115719,   DOI: 10.1080/14686996.2019.1627174,   PubMed: 31275462,   Elsevier: Scopus)
18. Tatsuhiro Ishida :
生体内動態の理解を基盤としたリポソームDDSの開発∼臨床応用を目指して∼ 第11回日本DDS学会水島賞によせて,
Drug Delivery System, Vol.33, No.4, 318-328, Sep. 2018.
(DOI: 10.2745/dds.33.318,   Elsevier: Scopus)
19. Yu Ishima, 丸山 徹, Tatsuhiro Ishida and 小田切 優樹 :
Control of EPR effect by tumor-targeted NO donor via endogenous albumin transport system,
Drug Delivery System, Vol.33, No.2, 130-138, Mar. 2018.
(DOI: 10.2745/dds.33.130,   CiNii: 1390282763015033344)
20. Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
Accelerated blood clearance (ABC) 現象における動物種差,
Drug Delivery System, Vol.32, No.5, 396-401, Nov. 2017.
(DOI: 10.2745/dds.32.396,   CiNii: 1390001204641700864)
21. Lila Selim Ahmed Ali Abu Amr and Tatsuhiro Ishida :
Metronomic chemotherapy and nanocarrier platforms,
Cancer Letters, Vol.400, 232-242, Aug. 2017.
(DOI: 10.1016/j.canlet.2016.11.007,   PubMed: 27838415,   Elsevier: Scopus)
22. Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
ナノ粒子に対する補体活性化の功罪,
Drug Delivery System, Vol.32, No.3, 199-207, Aug. 2017.
(DOI: 10.2745/dds.32.199,   CiNii: 1390282679617948032)
23. Lila Selim Ahmed Ali Abu Amr, Hiroshi Kiwada and Tatsuhiro Ishida :
Liposomal delivery systems: design optimization and current applications,
Biological & Pharmaceutical Bulletin, Vol.40, No.1, 1-10, Jan. 2017.
(DOI: 10.1248/bpb.b16-00624,   PubMed: 28049940)
24. Taro Shimizu and Tatsuhiro Ishida :
Characteristics, evaluation and suppression of anti-poly(ethylene glycol) antibody,
Drug Delivery System, Vol.31, No.4, 300-307, Jun. 2016.
(DOI: 10.2745/dds.31.300,   CiNii: 1390001204640457984)
25. Tatsuhiro Ishida :
PEGに対する免疫反応∼PEG修飾製剤の安全性に関する研究∼,
製剤機械技術学会誌, Vol.24, No.5, 78-83, Dec. 2015.
26. Masami Ukawa, Hidenori ANDO, Taro Shimizu and Tatsuhiro Ishida :
Pharmaceutics of Nanoparticles,
Nanomaterials in Pharmacology, 219-238, Nov. 2015.
(DOI: 10.1007/978-1-4939-3121-7_11)
27. Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Selective delivery of oxaliplatin to tumor tissue by nanocarrier system enhances overall therapeutic efficacy of the encapsulated oxaliplatin,
Biological & Pharmaceutical Bulletin, Vol.37, No.2, 206-211, Feb. 2014.
(DOI: 10.1248/bpb.b13-00540,   PubMed: 24492717,   CiNii: 1390282679609960064,   Elsevier: Scopus)
28. Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage,
Journal of Controlled Release, Vol.172, No.1, 38-47, Aug. 2013.
(DOI: 10.1016/j.jconrel.2013.07.026,   PubMed: 23933235)
29. Tatsuhiro Ishida and Hiroshi Kiwada :
Anti-polyethyleneglycol (PEG) antibody response to PEGylated substances.,
Biological & Pharmaceutical Bulletin, Vol.36, No.6, 889-891, Jun. 2013.
(DOI: 10.1248/bpb.b13-00107,   PubMed: 23727911)
30. Tatsuhiro Ishida and Hiroshi Kiwada :
PEG修飾製剤による抗PEG抗体分泌誘導,
ファルマシア:最前線, Vol.49, No.6, 503-507, Jun. 2013.
31. Tatsuhiro Ishida and Hiroshi Kiwada :
Alteration of tumor microenvironment for improved delivery and intratumor distribution of nanocarriers.,
Biological & Pharmaceutical Bulletin, Vol.36, No.5, 692-697, May 2013.
(DOI: 10.1248/bpb.b13-00121,   PubMed: 23649327)
32. Tatsuhiro Ishida :
リポソームDDSの開発研究∼トランスレーショナルリサーチの実現を目指して∼,
Journal of Pharmaceutical Science and Technology, Japan, Vol.71, 315-320, Nov. 2011.
(CiNii: 1390845713054819072)
33. Tatsuhiro Ishida and Hiroshi Kiwada :
PEG修飾リポソーム製剤繰り返し投与による血中滞留性低下,
C&I Commun., Vol.36, 19-21, 2011.
(CiNii: 1520290884281863808)
34. Tatsuhiro Ishida :
Development of efficient and safe drug delivery system with liposomes : the 2nd Encouragement Award in the 26th Annual Meeting of the Japan Society of Drug Delivery System,
Drug Delivery System, Vol.25, No.5, 511-516, Oct. 2010.
(CiNii: 1520290883385786880)
35. Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Targeting anticancer drugs to tumor vasculature using cationic liposomes.,
Pharmaceutical Research, Vol.27, No.7, 1171-1183, Mar. 2010.
(DOI: 10.1007/s11095-010-0110-1,   PubMed: 20333455)
36. 小出 裕之, 浅井 知浩, 畑中 剣太朗, 清水 広介, 横山 昌幸, Tatsuhiro Ishida, Hiroshi Kiwada and 奥 直人 :
Elucidation of Accelerated Blood Clearance Phenomenon Caused by Repeat Injection of PEGylated Nanocarriers,
Journal of the Pharmaceutical Society of Japan, Vol.129, No.12, 1445-1451, Dec. 2009.
(DOI: 10.1248/yakushi.129.1445,   CiNii: 1390001206128807680)
37. Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Recent advances in tumor vasculature targeting using liposomal drug delivery systems.,
Expert Opinion on Drug Delivery, Vol.6, No.12, 1297-1309, Dec. 2009.
(DOI: 10.1517/17425240903289928,   PubMed: 19780711)
38. Tatsuhiro Ishida, Tatsuaki Tagami and Hiroshi Kiwada :
siRNA を利用したArgonaute2 遺伝子knockdown によるがん治療法の開発,
和光純薬時報, Vol.77, No.2, 8-11, Apr. 2009.
39. Tatsuhiro Ishida and Hiroshi Kiwada :
Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes.,
International Journal of Pharmaceutics, Vol.354, No.1-2, 56-62, Apr. 2008.
(DOI: 10.1016/j.ijpharm.2007.11.005,   PubMed: 18083313)
40. Tatsuhiro Ishida and Hiroshi Kiwada :
Accelerated Blood Clearance (ABC) Phenomenon Induced by Administration of PEGylated Liposome(Symposium Reviews),
Journal of the Pharmaceutical Society of Japan, Vol.128, No.2, 233-243, Feb. 2008.
(DOI: 10.1248/yakushi.128.233,   CiNii: 1390001206127402624)
41. Tatsuhiro Ishida :
腫瘍血管の構造変化がナノ粒子抗がん剤の効果を変化させる,
Farumashia, Vol.44, No.2, 168-169, Feb. 2008.
42. Tatsuhiro Ishida and Hiroshi Kiwada :
ポリマー修飾ナノ微粒子投与による免疫活性化に関する研究,
表面, Vol.45, No.10, 357-371, Oct. 2007.
43. Tatsuhiro Ishida :
デリバリーによる新たな創薬,
薬事日報, Vol.10368, 8, Apr. 2007.
44. Tatsuhiro Ishida and Hiroshi Kiwada :
リポソームと細胞の相互作用(DDSへの応用),
MEMBRANE, Vol.32, No.1, 18-24, Jan. 2007.
(DOI: 10.5360/membrane.32.18)
45. Tatsuhiro Ishida, Yoshihiro Takanashi and Hiroshi Kiwada :
Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil.,
Biological & Pharmaceutical Bulletin, Vol.29, No.3, 397-402, Mar. 2006.
(DOI: 10.1248/bpb.29.397,   PubMed: 16508135)
46. Tatsuhiro Ishida and Hiroshi Kiwada :
がん治療を目指した機能性リポソームの開発研究,
Chemical Industry, Vol.57, 39-43, 2006.
47. Tatsuhiro Ishida :
リポソームDDSの開発研究,
薬剤学, Vol.65, 28-33, 2005.
48. Tatsuhiro Ishida and Hiroshi Kiwada :
Accelerated blood clearance of PEGylated liposomes after repeated injection,
Drug Delivery System, Vol.19, No.6, 495-510, Nov. 2004.
(DOI: 10.2745/dds.19.495,   CiNii: 1390001204640586880)
49. Tatsuhiro Ishida :
Development of Drug Delivery System for Intrathecal Administration and Its Therapeutic Effect on Cerebral Vasospasm and Ischemia,
Journal of the Pharmaceutical Society of Japan, Vol.124, No.8, 541-547, Aug. 2004.
(DOI: 10.1248/yakushi.124.541,   CiNii: 1390282681105634816)
50. Tatsuhiro Ishida, 高梨 吉裕 and Hiroshi Kiwada :
脳脊髄腔内直接投与可能なDDSの開発とその脳保護効果,
月刊 薬事, Vol.46, No.7, 1333-1338, Jun. 2004.
51. Tatsuhiro Ishida and Hiroshi Kiwada :
DDS研究の現状,
科学フォーラム, 22-28, Dec. 2003.
52. Tatsuhiro Ishida :
機能性リポソームの開発とその癌治療への応用,
月刊 薬事, Vol.45, No.7, 1125-1132, May 2003.
53. Tatsuhiro Ishida :
癌とDDS,
癌と人, Vol.30, 28-29, Mar. 2003.
54. Tatsuhiro Ishida, H Harashima and Hiroshi Kiwada :
Liposome clearance.,
Bioscience Reports, Vol.22, No.2, 197-224, Apr. 2002.
(DOI: 10.1023/a:1020134521778)
55. Tatsuhiro Ishida :
リポソームへの機能性の付加による細胞内薬物送達システムの開発,
Drug Delivery System, Vol.17, 136-137, 2002.
56. Hideyoshi Harashima, Tatsuhiro Ishida, Hiroyuki Kamiya and Hiroshi Kiwada :
Pharmacokinetics of Targeting with Liposomes,
Critcal Reviews in Therapeutic Drug Carrier Systems, Vol.19, No.3, 235-275, 2002.
(DOI: 10.1615/CritRevTherDrugCarrierSyst.v19.i3.20)
57. Tatsuhiro Ishida, H Harashima and Hiroshi Kiwada :
Interactions of Liposomes with Cells In Vitro and In Vivo:Opsonins and Receptors,
Current drug metabolism, Vol.2, No.4, 397-409, Dec. 2001.
(DOI: 10.2174/1389200013338306)
58. Tatsuhiro Ishida :
MDRモジュレーターとリポソーム化抗癌剤による多剤耐性癌克服の試み,
Xenobio.Metabol.And.Dispos., Vol.15, No.5, 486-488, Oct. 2000.
59. Tatsuhiro Ishida and Hiroshi Kiwada :
リポソーム,
色材, Vol.72, 184-191, 1999.

Proceeding of International Conference:

1. Haruka Takata, Shunji Abe, Taro Shimizu, Hidenori ANDO and Tatsuhiro Ishida :
Impact of pre-existing anti-PEG IgM on the mRNA/LNP i.m. vaccination,
16th International Symposium on Nanomedicine, Osaka, Nov. 2023.
2. Taro Shimizu, Yoshino Kawaguchi and Tatsuhiro Ishida :
Role of B cells in antitumor immune responses induced by antigen-loaded hydroxyl PEG-modified liposomes,
16th International Symposium on Nanomedicine, Osaka, Nov. 2023.
3. Hitoshi Matsumoto, Haruka Takata, Ayano Sawa-Aihara, Taro Shimizu, Hidenori ANDO and Tatsuhiro Ishida :
Investigation of therapeutic efficacy of proteasome inhibitor-encapsulated PEG-modified liposomes for UUO-induced renal fibrosis,
16th International Symposium on Nanomedicine, Osaka, Nov. 2023.
4. Shoichiro Fukuda, Hidenori ANDO, Chihiro Kato, Haruka Takata, T Nakae, N Tatsumi, H Hamamoto and Tatsuhiro Ishida :
The molecular weight limitation on increased intestinal absorption by ionic liquids,
16th International Symposium on Nanomedicine, Osaka, Nov. 2023.
5. E Kaneko, H Tsujisaki, M Fujiwara, Hidenori ANDO, Tatsuhiro Ishida, H Tani and K Tajima :
Suppression of mechanical stress in suspension culture of mammalian cells by nanofibrillated bacterial cellulose,
The 5th International Cellulose Conference (ICC2022+1), Hiroshima, Sep. 2023.
6. Tatsuhiro Ishida :
Immunological responses against PEGylated materials: the induction of anti-PEG antibodies,
1st BI Nanocarrier Symposium 2023 Nanocarrier Technology in Drug Discovery, Development and Clinic, Kobe, Feb. 2023.
7. Haruka Yamamoto, Hidenori ANDO, Omoto Yasukazu, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
Induction of neutralizing antibodies by immunization with inactivated human TNF-alpha in mice,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
8. Shunto Yamamoto, Hidenori ANDO, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
Development of a novel technique for antibody induction against membrane proteins by spleen immunization with membrane protein-loaded PEG-modified liposomes,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
9. Takaaki Matsuzaki, Taro Shimizu, Hidenori ANDO, Yu Ishima, K Yamanaka, H Hamamoto and Tatsuhiro Ishida :
An ionic liquids-based topical antitumor vaccine: a mechanism for induction of antitumor immunity via topical application of cancer-antigen peptides,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
10. Aiko Hashimoto, Yu Ishima, Hidenori ANDO, Taro Shimizu and Tatsuhiro Ishida :
Differential organ-specific distribution of human serum albumin denatured by various modifications,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
11. Riku Uehara, Hidenori ANDO, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
Neutralization of acidic tumor microenvironment by dosing of sodium potassium citrate (K/Na citrate) enhances antitumor effects of Abraxane®,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
12. Shoichiro Fukuda, Hidenori ANDO, Atsuya Maruyama, Takashi Nakae, Noboru Tatsumi, Hidetoshi Hamamoto, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
The mechanism investigation of intestinal absorption enhancement of drugs using ionic liquids,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
13. Eslam Mostafa Ramadan Abdelhameed, Hidenori ANDO, Haruka Yamamoto, Mako Fukumoto, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
Preparation, optimization, and evaluation of anionic DPPG-based LNPs for delivery of peptide antigens,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
14. Nana Matsuo, Hidenori ANDO, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
Oral sodium bicarbonate enhances accumulation and antitumor effects of PEGylated liposomal doxorubicin (Doxil®),
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
15. Yoshino Kawaguchi, Taro Shimizu, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Transfusion of mouse B cells, embedded antigens with hydroxyl PEG-modified liposomes in vitro, induces cellular immune responses in mice,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
16. A S Gaballa, Taro Shimizu, Hidenori ANDO, Yu Ishima, Sherif Abdallah Emam Emam, M Ibrahim, M F Mady, W Y Naguib, A K Khaled and Tatsuhiro Ishida :
Accelerated blood clearance of PEGylated liposomal antitumor agents after topical application of PEG derivatives containing cosmetics in a mouse model,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
17. Hidenori ANDO, K Tajima, T Matsushima, T Kusano and Tatsuhiro Ishida :
Functions of exosomes secreted from nano-fibrillated bacterial cellulose-based 3D spheroids derived from cancer cells or mesenchymal stem cells,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
18. Taro Shimizu, H Hamamoto and Tatsuhiro Ishida :
Application of ionic liquids for transcutaneous delivery of hydrophilic macromolecules,
15th International Symposium on Nanomedicine, Tokushima, Dec. 2022.
19. Takeru Hirai, Nanami Tasaka, Hidenori ANDO, Taro Shimizu, Tatsuhiro Ishida and Yu Ishima :
Biological roles of supersulfide in human hair,
Redox Week in Sendai 2022, Sendai, Oct. 2022.
20. Yamade Rina, Taro Shimizu, Hirakawa Naoki, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
Human serum albumin (HSA)-based nanocarriers efficiently deliver antigens to the spleen and induce antigen-specific humoral immunity,
14th International Symposium on Nanomedicine, Nov. 2021.
21. Haruka Takata, Taro Shimizu, Ueda Hiro, Hidenori ANDO, Yu Ishima and Tatsuhiro Ishida :
The induction level of anti-PEG IgM by PEGylated liposomes depends on the route of administration and the presence of nucleic acids,
14th International Symposium on Nanomedicine, Nov. 2021.
22. Hidenori ANDO, Tajima Kenji, Matsushima Tokuo, Kusano Takatomo and Tatsuhiro Ishida :
Evaluation of exosomes derived from spheroids prepared by 3D cell culture system using nano-fibrillated bacterial cellulose,
14th International Symposium on Nanomedicine, Nov. 2021.
23. Taro Shimizu, Haruka Takata, Milad Reda Qelliny and Tatsuhiro Ishida :
Evaluation of immunogenicity and adverse effects of nucleic acid-loaded nanoparticles,
14th International Symposium on Nanomedicine, Online, Nov. 2021.
24. Tatsuhiro Ishida and Taro Shimizu :
A novel antigen delivery system: Antigen-selective delivery to splenic marginal zone B cells via repeated injections of PEGylated liposomes,
13th Anniversary International Symposium on Nanomedicine, Kobe, Dec. 2019.
25. Taro Shimizu and Tatsuhiro Ishida :
Liposomal anticancer drugs enhanced antitumor effect of cancer immunotherapy by modulating immune systrem,
13th Anniversary International Symposium on Nanomedicine, Kobe, Dec. 2019.
26. Mayumi Ikeda, Yu Ishima, T Maruyama, T Akaike, M Otagiri and Tatsuhiro Ishida :
A novel S-sulfhydrated human serum albumin suppresses reactive oxygen species induced by kidney injuries,
17th International Symposium on Blood Substitutes & Oxygen Therapeutics, Nara, Nov. 2019.
27. Taro Shimizu, Kohga Miyahara, G Kozma, Hidenori ANDO, Yu Ishima, J Szebeni and Tatsuhiro Ishida :
Pre-treatment with Doxebo suppresses anti-PEG IgM immune responses through PEG-specific immune tolerance,
17th International Symposium on Blood Substitutes & Oxygen Therapeutics, Nara, Nov. 2019.
28. Tatsuhiro Ishida :
Immunological response to PEGylated liposomes: production of anti-PEG antibodies and their affection on PK of second dose,
17th International Symposium on Blood Substitutes & Oxygen Therapeutics, Nara, Nov. 2019.
29. Tatsuhiro Ishida and Taro Shimizu :
A novel antigen delivery system: Antigen-selective delivery to splenic marginal zone B cells via repeated injections of PEGylated liposomes,
Liposome Research Days 2019, Sapporo, Sep. 2019.
30. Nehal Ali Emam Elsadek Emam Elhewan, Taro Shimizu and Tatsuhiro Ishida :
PEG-G-CSF immunogenicity in mice: Anti-PEG IgM induction,
Liposome Research Days 2019, Sapporo, Sep. 2019.
31. Sherif Abdallah Emam Emam, Hidenori ANDO, Taro Shimizu and Tatsuhiro Ishida :
The impact of cell-type tropism on the intratumor accumulation of exosomes derived from cancer cells,
Liposome Research Days 2019, Sapporo, Sep. 2019.
32. M Mohamed, Taro Shimizu and Tatsuhiro Ishida :
Macrophages contribute to anti-PEG IgM production and the subsequent accelerated blood clearance of PEGylated liposomes,
Liposome Research Days 2019, Sapporo, Sep. 2019.
33. Taro Shimizu, Shunsuke Takese, Yu Ishima and Tatsuhiro Ishida :
Combination of cancer vaccines with liposomal oxaliplatin increased anti-cancer therapeutic efficacy by stimulating antitumor immunity,
Liposome Research Days 2019, Sapporo, Sep. 2019.
34. Maho Tagami, Hidenori ANDO, Ai Ikeda, K Eshima, C.L Huang, H Wada and Tatsuhiro Ishida :
Enhanced therapeutic efficacy of liposomal weak-base anticancer drugs by daily oral administration of sodium bicarbonate,
Liposome Research Days 2019, Sapporo, Sep. 2019.
35. Haruka Takata, Taro Shimizu and Tatsuhiro Ishida :
Gene therapy with lipoplexes may worsen inflammation via formation of immune complexes with pre-existing anti-DNA antibodies in SLE-prone mice,
Liposome Research Days 2019, Sapporo, Sep. 2019.
36. Yuna Shimazaki, Hidenori ANDO, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
Immunization method to obtain antigen-specific antibodies by antigen delivery to splenic marginal zone B cells using PEGylated liposomes,
Liposome Research Days 2019, Sapporo, Sep. 2019.
37. Mayumi Ikeda, Yu Ishima, H Watanabe, T Maruyama, M Otagiri and Tatsuhiro Ishida :
Functional Elucidation of Polysulfides In Serum Albumin and Development of Biomimetic Donor of Polysulfides,
2019 CRS Annual Meeting & Exposition, Valencia, Jul. 2019.
38. Tatsuhiro Ishida and Taro Shimizu :
Immunological responses against PEGylated liposomes: the application of ABC phenomenon into cancer vaccine,
12th International Symposium on Nanomedicine, Ube, Dec. 2018.
39. Kohki Tachibana, Tamotsu Tanaka, Kentaro Kogure, Tatsuhiro Ishida and Keiichiro Okuhira :
Sphingosine-1-phosphate (S1P) affects the secretion of high density lipoprotein (HDL)-constituent protein,
12th International Symposium on Nanomedicine, Ube, Dec. 2018.
40. Mayumi Ikeda, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
A Novel S-Sulfhydrated Serum Albumin Preparation Suppresses Melanin Synthesis,
AAPS PharmSci 360, Washington, D.C., Nov. 2018.
41. Tatsuhiro Ishida :
Immunological responses against PEGylated liposomes: Application for cancer vaccine,
13th France-Japan Drug Delivery Systems Symposium, Shima, Oct. 2018.
42. Tatsuhiro Ishida :
Anti-polyethylene-glycol Antibody Response to PEGylated Nanoparticles,
CLINAM summit 2018, Basel, Sep. 2018.
43. Emam Emam Abdallah Sherif, Hidenori ANDO, Lila Selim Ahmed Ali Abu Amr, Yu Ishima, A M Mahdy, S F Ghazy and Tatsuhiro Ishida :
The effect of liposome co-incubation with cancer cells on the secretion, uptake propensity and expression of certain surface proteins of cancer cell-derived exosomes (extracellular vesicles),
2018 CRS Annual Meeting & Exposition, New York, Jul. 2018.
44. Nanami Tasaka, Mayumi Ikeda, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
Reactive Sulfur Species in Human Hair Keratin Respond To Oxidative Stress,
5th World Congress on Hydrogen Sulfide in Biology&Medicine, Toronto, Jun. 2018.
45. Shota Fujimoto, Naoki Muguruma, Michiyasu Nakao, Yoshihiko Miyamoto, Tatsuhiro Ishida, Shigeki Sano and Tetsuji Takayama :
Near-Infrared Molecular Imaging of Gastrointestinal Stromal Tumors using a Novel Fluorescent Probe Indocyanine Green (ICG)-Labeled Dasatinib.,
Digetive Disease Week2018, Washington, D.C., Jun. 2018.
46. Mayumi Ikeda, Nanami Tasaka, Taro Shimizu, Yu Ishima and Tatsuhiro Ishida :
A Novel S-Sulfhydrated Human Serum Albumin Preparation Suppresses Melanin Synhtesis,
5th World Congress on Hydrogen Sulfide in Biology&Medicine, Toronto, Jun. 2018.
47. Tatsuhiro Ishida :
Immunological responses to PEGylated materials ABC phenomenon and application to vaccine,
International Seminar Programme Drug Innovation (University of Utrecht), Utrecht, Jan. 2018.
48. Tatsuhiro Ishida :
Immunological responses against PEGylated materials: the accelerated blood clearance (ABC) issue,
International Symposium on Nanomedicine 2017, Sendai, Dec. 2017.
49. Takuma Maitani, Masami Ukawa, S Ishii, G Nohara, H Abutani, N Anderson and Tatsuhiro Ishida :
Investigation on antitumor effect and systemic toxicity by repeated injection of thermosensitive liposome encapsulating doxorubicin (ThermoDox®),
ILS Liposome Advances and Liposome Research Days Combined Conference, Athens, Sep. 2017.
50. Tatsuhiro Ishida :
Immunological response to PEGylated nanoparticles: Anti-PEG antibody issues,
ILS Liposome Advances and Liposome Research Days Combined Conference, Athens, Sep. 2017.
51. Tatsuhiro Ishida, Hidenori ANDO, M Fukushima, C.L Huang and H Wada :
An industrial method of manufacturing a novel RNAi anticancer drug, DFP-10825, for the treatment of peritoneal disseminated gastric cancer,
AACR Annual Meeting 2017, Washington, D.C., Apr. 2017.
52. C Jin, K Eshima, M Fukushima, Tatsuhiro Ishida, C.L. Huang and H Wada :
DFP-10825 ip delivery provides a new effective treatment option to peritoneal disseminated cancers,
AACR Annual Meeting 2017, Washington, D.C., Apr. 2017.
53. Masami Ukawa, Yuki Kanazawa and Tatsuhiro Ishida :
Doxorubicin enhanced nuclear entry of liposomal DNA via induction of the nuclear swelling,
International Symposium on Drug Delivery and Pharmaceutical Sciences: Beyond the History, Kyoto, Mar. 2017.
54. Tatsuhiro Ishida :
Developent of RNAi-based anticancer drug: What is problem for clinical application and how establish a useful RNAi drug,
2016 International Conference of the Korea Society of Pharmaceutical Sciences and Technology, Seoul, Dec. 2016.
55. Tatsuhiro Ishida :
Development of a RNAi-based anticancer drug.,
12th France-Japan Drug Delivery Systems Symposium, Paris, Oct. 2016.
56. Tatsuhiro Ishida :
Anti-PEG immunity against PEGylated materials.,
An international workshop for Immune Effects of Nanomedicines: Clinical and Experimental Evidence, Prediction and Prevention., Budapest, Jun. 2016.
57. Takuma Takayama, Taro Shimizu, Masami Ukawa and Tatsuhiro Ishida :
Liposomal doxorubicin (DXR) exerts antitumor effect via securing antitumor immunity against DXR in tumor microenvironment,
Liposome Advances 2015, London, Dec. 2015.
58. Nozomi Kinjoh, Hidenori ANDO, Noriko Saito-Tarashima, Noriaki Minakawa and Tatsuhiro Ishida :
Targeted gene silencing by introduction of intelligent RNA expression device (iRed),
Liposome Advances 2015, London, Dec. 2015.
59. Yuka Kitayama, Ryo Abe, Taro Shimizu and Tatsuhiro Ishida :
Anti-PEG IgM production induced by siRNA-containing PEGylated liposome,
Liposome Advances 2015, London, Dec. 2015.
60. Mizuki Awata, Risako Fujita, Yu Mima, Munehira Kawanishi, Taro Shimizu and Tatsuhiro Ishida :
Altering PEGylated liposomes modification from DSPE-PEG-OCH3 to DSPE-PEG-OH suppresses secretion of anti-PEG IgM and proliferation of PEG-specific B cell,
Liposome Advances 2015, London, Dec. 2015.
61. Noriko Saito-Tarashima, Kinjo Nozomi, Kojima Takamitsu, Hidenori ANDO, Tatsuhiro Ishida and Noriaki Minakawa :
Gene silencing via RNA interference (RNAi) machinery using 4'-thioDNA as an artificial template,
The 42nd International Symposium on Nucleic Acids Chemistry, Himeji, Sep. 2015.
62. Tatsuhiro Ishida :
The role of B cells and anti-PEG IgM in the ABC phenomenon against PEGylated liposome,
LNP interactions with the immune system; Mechanistic Insights, Cambridge, Mar. 2015.
63. Tatsuhiro Ishida :
Anti-PEG immunity against PEGylated materials,
11th DDS Symposium France-Japan, Awaji, Oct. 2014.
64. Taro Shimizu, Yuki Watanabe, Yu Mima, Tatsuhiro Ishida and Hiroshi Kiwada :
Antigen delivery with PEGylated liposome and presentation via MZ-B cells enhanced induction of antigen-specific cytotoxic T lymphocyte,
Liposome Research Days 2014, Copenhagen, Aug. 2014.
65. Munehira Kawanishi, Yosuke Hashimoto, Taro Shimizu, I Sagawa, Tatsuhiro Ishida and Hiroshi Kiwada :
Comprehensive analysis of proteins bound on PEGylated liposome relating to the accelerated blood clearance (ABC) phenomenon by shotgun analysis,
Liposome Research Days 2014, Copenhagen, Aug. 2014.
66. Sakiko Kobayashi, Lila Selim Ahmed Ali Abu Amr and Tatsuhiro Ishida :
Influence of retention time of liposome in thoracic cavity and release rate of Pemetrexed encapsulated in it for malignant pleural methothelioma therapy,
Liposome Research Days 2014, Copenhagen, Aug. 2014.
67. Yukako Fujiwara, Hiroyuki Nakamura, Tatsuhiro Ishida and Hiroshi Kiwada :
Increased PEG-coated liposomal l-OHP accumulation in the liver relates antitumor effect against M5076 ovarian sarcoma liver metastasis,
Liposome Research Days 2014, Copenhagen, Aug. 2014.
68. Yu Mima, Taro Shimizu, Hiroshi Kiwada and Tatsuhiro Ishida :
Inclusion of ganglioside into PEGylated liposome suppresses the anti-PEG immunity against PEGylated liposome,
Liposome Research Days 2014, Copenhagen, Aug. 2014.
69. Chihiro Katoh, Lila Selim Ahmed Ali Abu Amr and Tatsuhiro Ishida :
The effect of intrapleural environment and physicochemical properties of liposome/lipoplex on its retention time after intrapleural injection,
Liposome Research Days 2014, Copenhagen, Aug. 2014.
70. Tatsuhiro Ishida :
Immunological Response to PEGylated Nanocarriers: Anti-PEG immunity,
Liposome Research Days 2014, Copenhagen, Aug. 2014.
71. Kohsuke Takahashi, Miho Nishio and Tatsuhiro Ishida :
Long interval between Doxil® treatments causes Doxil® resistance in Colon26-bearing mouse,
Liposome Research Days 2014, Copenhagen, Aug. 2014.
72. Yusuke Doi, Tatsuhiro Ishida and Hiroshi Kiwada :
Characterization of optimally designed liposomal formulation of Oxaliplatin,
The 41st Annual Meeting & Exposition of the Controlled Release Society, Chicago, Jul. 2014.
73. Tatsuhiro Ishida :
Improvement of tumor-targeting therapy with nanocarrier system by changing the tumor microenvironment,
Shnchrotron Radiation in Nano-medicine and Advanced Health Care (SRNAHC), Kobe, Jan. 2014.
74. Noriko Saito-Tarashima, Kojima Takamitsu, Hashimoto Yosuke, Kazuhiro Furukawa, Naoshi Yamazaki, Hiroshi Kiwada, Tatsuhiro Ishida, Noriaki Minakawa and Yoshiharu Takiguchi :
A novel approach of gene suppression using an intelligent shRNA expressing device (iRed),
9th Annual Meeting of the Oligonucleotide Therapeutics Society, Naples(Italy), Oct. 2013.
75. Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Potentiation of specific antibody response against antigen encapsulated in PEGylated liposomes via active transport of the liposomes from marginal zone into follicle,
5th Asian Arden Conference, Nagoya, Aug. 2013.
76. Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Transport of PEGylated liposomes to follicle induced by pre-stimulation of empty liposomes: Potentiating specific antibody responses against antigen encapsulated in the liposomes,
40th Annual Meeting & Exposition of the Controlled Release Society, Hawaii, Jul. 2013.
77. Yosuke Hashimoto, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Serum anti-PEG IgM concentration is a determinant factor on hepatic accumulation of PEGylated liposome in the accelerated blood clearance phenomenon,
40th Annual Meeting & Exposition of the Controlled Release Society, Hawaii, Jul. 2013.
78. Yu Mima, Yosuke Hashimoto, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Accelerated blood clearance phenomenon upon PEGylated protein,
40th Annual Meeting & Exposition of the Controlled Release Society, Hawaii, Jul. 2013.
79. Miho Nishio, Hiroyuki Nakamura, Tatsuhiro Ishida and Hiroshi Kiwada :
PEGylated liposomes injected sequentially distribute in different region of solid tumor,
40th Annual Meeting & Exposition of the Controlled Release Society, Hawaii, Jul. 2013.
80. Risako Fujita, Yosuke Hashimoto, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Effect of terminal group of PEG on induction of ABC phenomenon to PEGylated liposome,
40th Annual Meeting & Exposition of the Controlled Release Society, Hawaii, Jul. 2013.
81. Tatsuhiro Ishida :
Immunological response to PEGylated nanocarriers: anti-PEG immunity,
2013 Cancer Nanotechnology Gordon Research Conference, Mount Snow Resort, West Dover, VT, USA, Jul. 2013.
82. Tatsuhiro Ishida and Lila Selim Ahmed Ali Abu Amr :
Huang C., Wada, H., Fukushima, M., Kiwada. H., An entirely novel nanoparticle carrying a bioactive shRNA molecule (DFP-10825) could be clinically effective against the high risk patients with mesothelioma relapsed or refractory after treatment with pemetrexed based chemotherapy.,
24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Nov. 2012.
83. Tatsuhiro Ishida and Hiroshi Kiwada :
Improvement of tumor-targeting therapy with nanocarrier system by changing the tumor microenvironment.,
10th DDS Symposium France-Japan, France, Oct. 2012.
84. Tatsuhiro Ishida and Hiroshi Kiwada :
Improved intratumoral delivery of PEG-coated siRNA-lipoplexes by combination with metronomic S-1 dosing in a murine solid tumor model.,
Oligonucleotide Delivery: Biology, Engineering and Development, Austria, Oct. 2012.
85. Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Activation of splenic marginal zone B cell by PEGylated liposome with lower dose: triggering transport of antigen-containing second dose PEGylated liposome from marginal zone to follicle,
39th Annual Meeting & Exposition of the Controlled Release Society, Québec City, Jul. 2012.
86. Hiroyuki Nakamura, Yusuke Doi, Tatsuhiro Ishida and Hiroshi Kiwada :
Sequential dose of l-OHP containing PEGylated liposome improve the intratumor delivery and efficacy of PEGylated liposomal anticancer agents.,
39th Annual Meeting & Exposition of the Controlled Release Society, Québec City, Jul. 2012.
87. Yosuke Hashimoto, Tatsuhiro Ishida and Hiroshi Kiwada :
Anti-PEG IgM response against PEG-coated liposome is further increased by immune stimulation of siRNA via TLR7,,
39th Annual Meeting & Exposition of the Controlled Release Society, Québec City, Jul. 2012.
88. Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Contribution of spleen marginal zone B cells on anti-PEG IgM responses against PEGylated liposomes and transport of PEGylated liposomes.,
International Liposome Society 2011 meeting, University of London,, London, Dec. 2011.
89. Naoto Moriyoshi, Mariko Matsunaga, Kazuya Nakamura, Tatsuhiro Ishida and Hiroshi Kiwada :
Development of new cancer treatment strategy that combines PEG-coated siRNA-lipoplex with metronomic S-1 dosing.,
International Liposome Society 2011 meeting, University of London,, London, Dec. 2011.
90. Tatsuhiro Ishida and Hiroshi Kiwada :
Biological responses against lipid membrane containing PEG.,
3rd International Symposium on Surface and Interface of Biomaterials (SIB2011), Sapporo, Jul. 2011.
91. Tatsuhiro Ishida and Hiroshi Kiwada :
Improvement of tumor-targeting therapy with nanocarrier system by changing the tumor microenviroment,
2011 RCAA International Symposium Endogenous Ligands Modulating Anticancer Agents, Seoul, Feb. 2011.
92. Yuki Hashiguchi, Taro Shimizu, Masako Ichihara, Tatsuhiro Ishida and Hiroshi Kiwada :
PEG on nanocarriers induces anti PEG IgM production as a result of activation of immune system.,
Nano in Cancer: Linking Chemistry, Biology and Clinical Applications in vivo, Miami, Jan. 2011.
93. Tatsuhiro Ishida, Kazuya Nakamura, Yusuke Doi, Naoto Moriyoshi and Hiroshi Kiwada :
A novel double modulation strategy in cancer treatment with chemotherapeutic agent and siRNA: S-1 improves siRNA accumulation and then Bcl-2 knockdown by the siRNA increases chemosensitivity of 5-FU.,
Nano in Cancer: Linking Chemistry, Biology and Clinical Applications in vivo, Miami, Jan. 2011.
94. Yuki Hashiguchi, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Sequential treatment, pre-dose with empty PEGylated liposome (SL) and second dose antigen-encapsulating SL, promotes activation in a primary immune response.,
International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics, Vancouver, Aug. 2010.
95. Haruna Matsumoto, Yusuke Doi, Tatsuhiro Ishida and Hiroshi Kiwada :
Tumor localization and therapeutic effect of PEG-coated liposomal anticancer agent: Tumor type-dependency.,
International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics, Vancouver, Aug. 2010.
96. Tomoko Okada, Yusuke Doi, Lila Selim Ahmed Ali Abu Amr, Tatsuhiro Ishida and Hiroshi Kiwada :
Metronomic oral S-1, a fluoropyrimidine anticancer agent, dosing affects tumor accumulation of PEG-coated liposome.,
International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics, Vancouver, Aug. 2010.
97. Mariko Matsunaga, Kazuya Nakamura, Yusuke Doi, Naoto Moriyoshi, Tatsuhiro Ishida and Hiroshi Kiwada :
DEVELOPMENT OF NEW CANCER TREATMENT STRATEGY THAT COMBINES siRNA-LIPOPLEX WITH ORAL TEGAFUR ANTICANCER DRUG S-1.,
International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics, Vancouver, Aug. 2010.
98. Takahiro Iwaki, Tatsuaki Tagami, Kazuya Nakamura, Tatsuhiro Ishida and Hiroshi Kiwada :
THE EFFECT OF PEGYLATION OF siRNA-LIPOPLEX ON INTRACELLULAR UPTAKE QUANTITY OF SIRNA AND INTRACELLULAR BEHAVIOR OF siRNA.,
International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics, Vancouver, Aug. 2010.
99. Masako Ichihara, Ami Imoto, Yuki Hashiguchi, Yumi Uehara, Tatsuhiro Ishida and Hiroshi Kiwada :
Spleen cells secret anti-PEG IgM following intravenous injection of PEGylated liposome.,
International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics, Vancouver, Aug. 2010.
100. Tatsuhiro Ishida and Hiroshi Kiwada :
Immunostimulatory properties of liposomes containing PEG.,
International Liposome Research Days & Lipids, Liposomes & Membrane Biophysics, Vancouver, Aug. 2010.
101. Yusuke Doi, Tomoko Okada, Haruna Matsumoto, Tatsuhiro Ishida and Hiroshi Kiwada :
Alteration of tumor microenvironment by metronomic S-1 dosing results in augmentation of EPR effect against PEG-coated liposomes.,
4th International Liposome Society Conference. Liposome advances: Progress in Drug and Vaccine Delivery, London, Dec. 2009.
102. Tatsuhiro Ishida, Kazuya Nakamura, Mariko Matsunaga, Yusuke Doi and Hiroshi Kiwada :
A novel double modulation strategy in cancer treatment with chemotherapeutic agent and siRNA: siRNA-induced Bcl-2 knockdown increases chemosensitivity against 5-FU and S-1 improves siRNA accumulation in human colorectal tumor xenograft model.,
4th International Liposome Society Conference. Liposome advances: Progress in Drug and Vaccine Delivery, London, Dec. 2009.
103. H Koide, T Asai, M Yokoyama, Tatsuhiro Ishida, Hiroshi Kiwada and N Oku :
Elucidation of ABC phenomenon caused by repeat injection of PEGylated nanocarrier.,
4th International Liposome Society Conference. Liposome advances: Progress in Drug and Vaccine Delivery, London, Dec. 2009.
104. Tatsuhiro Ishida and Hiroshi Kiwada :
Improvement of tumor-targeting therapy with nanocarriers by changing the tumor microenvironment.,
2009 International Symposium of the Intelligent Drug Delivery System, Seoul, Apr. 2009.
105. Tatsuhiro Ishida, Lila Selim Ahmed Ali Abu Amr, Takuya Suzuki, Yusuke Doi and Hiroshi Kiwada :
Oxaliplatin encapsulated in PEG-coated cationic liposome induces significant tumor growth suppression via dual-targeting approach in murine solid tumor model.,
AACR 100th Annual Meeting 2009, USA, Apr. 2009.
106. Yusuke Doi, Yurie Hira, Tatsuhiro Ishida and Hiroshi Kiwada :
Synergistic antitumor activity of metronomic S-1 dosing in combination with oxaliplatin (1-OHP) containing PEGylated liposome in a murine solid tumor model.,
AACR 100th Annual Meeting 2009, USA, Apr. 2009.
107. Tatsuhiro Ishida :
Improvement of tumor targeting therapy with nanocarriers by changing the tumor microenvironment.,
International exchange program between University of Tokushima and Seoul National University, Seoul, Mar. 2009.
108. Tatsuhiro Ishida and Hiroshi Kiwada :
Improvement of tumor targeting therapy with nanocarriers by changing the tumor microenvironment.,
6th international workshop on Drug Delivery Systems for Nanomedicine, Prague (the Czech Republic), Oct. 2008.
109. Tatsuaki Tagami, Kazuya Nakamura, Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Effect of siRNA on anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon when formulated with PEGylated cationic liposome.,
11th Liposome Research Days conference, Yokohama, Jul. 2008.
110. Takuya Suzuki, Kazuya Nakamura, Tatsuaki Tagami, Jose Mario Barichello, T Asai, Tatsuhiro Ishida, N Oku and Hiroshi Kiwada :
Anticancer activity of Argonaute2 (Ago2) gene silencing induced by siRNA in mouse tumor xenograft model.,
11th Liposome Research Days conference, Yokohama, Jul. 2008.
111. Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Interaction of PEGylated liposomes with splenic marginal zone B cells may trigger production of anti-PEG IgM in the ABC phenomenon.,
11th Liposome Research Days conference, Yokohama, Jul. 2008.
112. Shinji Kizuki, Jose Mario Barichello, Tatsuaki Tagami, H Kikuchi, Tatsuhiro Ishida and Hiroshi Kiwada :
The impact of novel siRNA-lipoplex preparation method on cellular uptake pathway and gene knockdown efficiency.,
11th Liposome Research Days conference, Yokohama, Jul. 2008.
113. Yusuke Doi, Yurie Hira, Tatsuhiro Ishida and Hiroshi Kiwada :
Metronomic dosing of oral anticancer agent affects microenvironment in solid tumor, resulting in enhanced intratumor accumulation and distribution of nanocarrior.,
11th Liposome Research Days conference, Yokohama, Jul. 2008.
114. Lila Selim Ahmed Ali Abu Amr, Takuya Suzuki, Yusuke Doi, Tatsuhiro Ishida and Hiroshi Kiwada :
Oxaliplatin (l-OHP) targeting to angiogenic vessels by PEGylated cationic liposomes suppresses the angiogenesis in a dorsal air sac mouse model.,
11th Liposome Research Days conference, Yokohama, Jul. 2008.
115. Jose Mario Barichello, Shinji Kizuki, Tatsuaki Tagami, T Asai, Tatsuhiro Ishida, K Hiroshi, N Oku and Hiroshi Kiwada :
Application of vortex-mixing during lipoplex formation affects siRNA-liposome association, siRNA internalization in cells and the RNAi effect.,
11th Liposome Research Days conference, Yokohama, Jul. 2008.
116. M Matsushita, (名) Asai, Y Suzuki, Tatsuhiro Ishida, N Maeda, T Dewa, Hiroshi Kiwada, (名) Nango and N Oku :
Antiangiogenic effect by Argonaute2 knockdown used polycation liposome.,
11th Liposome Research Days conference, Yokohama, Jul. 2008.
117. Tatsuhiro Ishida and Hiroshi Kiwada :
Improvement of tumor targeting therapy with nanocarriers by changing the tumor microenvironment.,
11th Liposome Research Days conference, Yokohama, Jul. 2008.
118. Taro Shimizu, Tatsuhiro Ishida and Hiroshi Kiwada :
Accelerated blood clearance (ABC) phenomenon on PEGylated nanocarrier: Unexpected immune-reaction against PEGylated liposome.,
International Symposium on ``Nanotoxicology Assessment and Biomedical, Environmental Application of Fine Particles and Nanotubes'' (ISNT2008), Sapporo, Jun. 2008.
119. Tatsuhiro Ishida and Hiroshi Kiwada :
Unexpected immunological response against sterically stabilized, PEGylated, liposome after intravenous injection.,
International Symposium on ``Nanotoxicology Assessment and Biomedical, Environmental Application of Fine Particles and Nanotubes'' (ISNT2008), Sapporo, Jun. 2008.
120. Taisuke Matsuo, Naoshi Yamazaki, Tatsuhiro Ishida, Hiroshi Kiwada, Yasuo Shinohara and Masatoshi Kataoka :
Design, preparation and directional insertion of peptides into lipid bilayer membrane and heir application for the preparation of liposome of which surface could be coated by externally added antibody,
International symposium on system cell engineering by multi-scale manipulation, Nagoya, Nov. 2007.
121. H Miyauchi, K Ichikawa, T Urakami, S Yonezawa, K Shimizu, Tatsuhiro Ishida, Hiroshi Kiwada, T Asai and N Oku :
Antigen-conjugated liposomes enhanced hyposensitization immune therapy with extra-low doses.,
34th Annual Meeting & Exposition of the Controlled Release Society, USA, Jul. 2007.
122. T Asai, Y Suzuki, S Matsushita, J Yokota, Tatsuhiro Ishida, Hiroshi Kiwada and N Oku :
Development of antineovascular RNAi cancer therapy targeting to Argonaute 2.,
American Society of Gene Therapy's 10th annual Meeting, Seattle USA, May 2007.
123. Barichello M. Jose, Tatsuhiro Ishida, Soares A. L. Luiz, Shinji Kizuki, Tatsuaki Tagami, Kiyomi Hirose, Hideo Kobayashi, Kouichi Hashimoto, Hiroshi Kikuchi and Hiroshi Kiwada :
Agitation during siRNA-cationic liposomes (CL) complex formation is a key step to improve in vitro RNA interference by lipofection.,
American Society of Gene Therapy's 10th annual Meeting, Seattle USA, May 2007.
124. Tatsuhiro Ishida, Tatsuaki Tagami, Barichello M. Jose, Kiyomi Hirose, Naoshi Yamazaki, Tomohiro Asai, Naoto Oku and Hiroshi Kiwada :
Argonaute2 (Ago2) gene silencing by liposomal transfection with siRNA for Ago2 induces apoptosis on HT1080 cells and HUVECs.,
American Society of Gene Therapy's 10th annual Meeting, Seattle USA, May 2007.
125. Taisuke Matsuo, Naoshi Yamazaki, Tatsuhiro Ishida, Hiroshi Kiwada, Yasuo Shinohara and Masatoshi Kataoka :
Mutant coat proteins of Pf3 bacteriophage as models of membrane proteins and their interactions with lipid bilayer membrane,
Pre-Satellite Meeting of the 3rd Pharmaceutical Sciences World Congress (PSWC 2007) for and by Ph.D. students and postdoctoral fellows, Amsterdam, Apr. 2007.
126. Taisuke Matsuo, Naoshi Yamazaki, Tatsuhiro Ishida, Hiroshi Kiwada, Yasuo Shinohara and Masatoshi Kataoka :
Mutant coat proteins of Pf3 bacteriophage as models of membrane proteins and their interactions with lipid bilayer membrane,
International symposium on system cell engineering by multi-scale manipulation, Nagoya, Nov. 2006.
127. Tatsuhiro Ishida and Hiroshi Kiwada :
Immunological responses to liposome carriers,
The 1st FIP-APSTJ Joint Work Shop on Gene Delivery, Sapporo, Jul. 2006.
128. Tatsuhiro Ishida, Kazutaka Atobe, Wang Xinyu and Hiroshi Kiwada :
The influence of administration of PEGylated liposomal doxorubicin as a first dose on induction of accelerated blood clearance (ABC) phenomenon.,
8th US-Japan symposium on drug delivery systems, Hawaii, Dec. 2005.
129. Tatsuhiro Ishida, Masako Ichihara, Masae Harada, Shuntarou Kashima, Wang Xinyu and Hiroshi Kiwada :
IgM secreted in response to the first injection of PEGylated liposomes involves in induction of the ABC phenomenon.,
31st Annual Meeting and Exposition of the Controlled Release Society., Hawaii, Jun. 2004.
130. Hiroshi Kiwada and Tatsuhiro Ishida :
Immunological responses to nano-drug carriers.,
The 2nd Japan-Korea Joint Symposium on Drug Delivery and Therapy, Kyoto, May 2004.
131. Tatsuhiro Ishida, Masako Ichihara, Shuntarou Kashima, Wang Xinyu and Hiroshi Kiwada :
IgM secreted in response to injection of PEGylated liposomes causes accelerated blood clearance of a subsequent dose.,
9th Liposome Research Days Conference, Hsinchu, Taiwan, May 2004.
132. Tatsuhiro Ishida :
Nano drug carrier0biological milieu interactions: Immunological reaponses to PEGylated liposomes.,
International Symposium on Single-Molecule Bioanalysis and Nano-biodevice (SMBN) 2004, Kagawa, Mar. 2004.
133. Tatsuhiro Ishida, J M Kirchmeier, S Zalipsky and M T Allen :
Targeted delivery and subsequent programmed release of liposomal doxorubicin with Stealth pH-sensitive liposomes.,
7th Liposome Research Days Conference, California, USA, Apr. 2000.

Proceeding of Domestic Conference:

1. Mako Fukumoto, Hidenori ANDO, Reon Kuramoto, Haruka Takata and Tatsuhiro Ishida :
エクソソームの脾臓免疫による抗体誘導評価:ホスト細胞膜表面に対する結合性評価,
第2回日本抗体学会学術大会, Dec. 2023.
2. Haruka Yamamoto, Hidenori ANDO, Haruka Takata, 大本 安一 and Tatsuhiro Ishida :
新規hTNFαワクチン製剤の開発を目指した不活化hTNFα誘導体のマウスへの免疫と抗体誘導評価,
第2回日本抗体学会学術大会, Dec. 2023.
3. Tatsuhiro Ishida :
イオン液体を用いた中分子化合物の吸収促進技術の開発,
第10回DDS製剤臨床応用FG合宿討論会, Nov. 2023.
4. Haruka Takata, Shunji Abe, Hidenori ANDO and Tatsuhiro Ishida :
mRNA/LNPによるタンパク翻訳へ抗PEG IgMが及ぼす影響,
第10回DDS製剤臨床応用FG合宿討論会, Nov. 2023.
5. Masaki Takata, Hidenori ANDO, 田島 健次, 松島 得雄, 草野 貴友, Chikako Asada, Yoshitoshi Nakamura and Tatsuhiro Ishida :
物性の異なるナノセルロースを用いて調製したパクリタキセル包埋CNFの調製∼腹膜播種モデルマウスでの抗腫瘍効果の検討∼,
第62回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2023.