徳島大学 / 教育研究者総覧 --- 早渕康信

個人のホームページ

http://pediatrics.hosp.med.tokushima-u.ac.jp/pediatrics/top.html

https://researchmap.jp/YasunobuHayabuchi (researchmap)

https://orcid.org/0000-0001-6143-2673 (ORCID)

専門分野

○	小児循環器病学
○	先天性心疾患・心不全患者における心機能解析
○	血管平滑筋細胞の収縮拡張および増殖にかかわる制御
○	MDCTを用いた先天性心疾患の病態評価
○	心エコー検査による小児心疾患症例の心機能評価

研究テーマ

○	Pediatric Cardiology
○	Assessment of cardiac functionn in patients with congenital heart disease
○	Regulation of vascular smooth muscle cells
○	Morphological and functional assessment of congenital heart disease using MDCT
○	Assessment of cardiac function evaluated using echocardiography in children with heart disease

著書・論文

著書:

1.	早渕康信 : クエスチョン・バンク医師国家試験問題解説 2024, メデックメディア, 2023年4月.
2.	早渕康信 : 第117回医師国家試験問題解説国試対策問題編集委員会編集, メデックメディア, 2023年4月.
3.	早渕康信 : 「先天性心疾患・川崎病」イヤーノート 2024 内科・外科編岡庭豊編集, メデックメディア, 2023年3月.
4.	早渕康信 : 「心臓の発生」からだがみえる -人体の構造と機能- 医療情報科学研究所編集, メデックメディア, 2023年2月.
5.	早渕康信 : 心臓の発生, メデックメディア, 2023年2月.
6.	早渕康信 : 病気がみえる Vol.15 小児科第1版「循環器総論・先天性心疾患・後天性心疾患」, メディックメディア, 2022年10月. (キーワード) 先天性心疾患 / 小児循環器 / 小児科 / 循環器
7.	早渕康信 : 「心臓・脈管疾患」 CBT・医師国家試験のためのレビューブック小児科 2022-2023, , 2022年9月.
8.	早渕康信 : クエスチョン・バンク医師国家試験問題解説 2023, 国試対策問題編集委員会編集メディックメディア, 2022年4月.
9.	早渕康信 : 第116回医師国家試験問題解説, 国試対策問題編集委員会編集メディックメディア, 2022年4月.
10.	早渕康信 : イヤーノート 2023 内科・外科編岡庭豊編集「先天性心疾患・川崎病」, メディックメディア, 2022年3月.
11.	早渕康信 : 第115回医師国家試験問題解説, メディックメディア, 2021年3月.
12.	早渕康信 : イヤーノート 2022 内科・外科編「先天性心疾患・川崎病」, 岡庭豊編集メディックメディア, 2021年3月.
13.	早渕康信 : 病気がみえる Vol.2 循環器第5版「先天性心疾患」, 医療情報科学研究所編集 p.274-327, メディックメディア, 2021年, 2021年3月.
14.	早渕康信 : クエスチョン・バンク医師国家試験問題解説 2022, 国試対策問題編集委員会編集メディックメディア, 2021年2月.
15.	早渕康信 : 「心室中隔欠損」小児内科2020年52巻増刊号小児疾患診療のための病態生理1 改訂第6版, 株式会社東京医学社, 2020年12月.
16.	早渕康信 : 「心臓・脈管疾患」 CBT・医師国家試験のためのレビューブック小児科 2021-2022, メディックメディア, 2020年7月.
17.	早渕康信 : 第114回医師国家試験問題解説, メディックメディア, 2020年4月.
18.	早渕康信 : 「心臓・脈管疾患」イヤーノート 2021, メディックメディア, 2020年3月.
19.	早渕康信 : クエスチョン・バンク医師国家試験問題解説 2021, メディックメディア, 2020年2月.
20.	早渕康信 : 第113回医師国家試験問題解説国試対策問題編集委員会編集, メディックメデイア, 東京, 2019年4月.
21.	早渕康信 : 「心臓・脈管疾患」イヤーノート 2020 内科・外科編岡庭豊編集, メディックメデイア, 東京, 2019年3月.
22.	早渕康信 : クエスチョン・バンク医師国家試験問題解説 2020 国試対策問題編集委員会編集, メディックメディア, 東京, 2019年2月.
23.	早渕康信 : 「特発性/遺伝性肺動脈性肺高血圧」小児内科 2018年50巻増刊号「小児疾患の診断治療基準第5版」『小児内科』『小児外科』編集委員会共編, 株式会社東京医学社, 東京, 2018年11月.
24.	早渕康信 : CBT・医師国家試験のためのレビューブック小児科 2019-2020, メディックメディア, 東京, 2018年7月.
25.	早渕康信 : 「血管拡張薬」小児・成育循環器学日本小児循環器学会編集, 株式会社診断と治療社, 東京, 2018年7月.
26.	早渕康信 : 第112回医師国家試験問題解説国試対策問題編集委員会編集, メディックメディア, 東京, 2018年4月.
27.	早渕康信 : イヤーノート 2019 内科・外科編岡庭豊編集「心臓・脈管疾患」, メディックメディア, 東京, 2018年3月.
28.	早渕康信 : クエスチョン・バンク医師国家試験問題解説 2019 国試対策問題編集委員会編集, メディックメディア, 東京, 2018年3月.
29.	早渕康信 : 修正大血管転位心エコーゼロから始める複雑先天性心疾患 -小児∼成人まで杜徳尚・伊藤浩編集, 文光堂, 東京, 2017年6月.
30.	早渕康信 : 第111回医師国家試験問題解説, メディックメディア, 東京, 2017年5月.
31.	早渕康信 : クエスチョン・バンク医師国家試験問題解説 2018, メディックメディア, 東京, 2017年3月.
32.	早渕康信 : イヤーノート 2018 内科・外科編岡庭豊編集「心臓・脈管疾患」, メディックメディア, 東京, 2017年3月.
33.	早渕康信 : 病気がみえる Vol.2 循環器第4版「先天性心疾患」医療情報科学研究所編集, メディックメディア, 東京, 2017年3月.
34.	早渕康信 : レビューブック小児科 2017-2018, 国試対策問題編集委員会編集, 東京, 2016年9月.
35.	早渕康信 : 循環器疾患シンプル小児科学香美祥二編集, 南江堂, 東京, 2016年4月.
36.	早渕康信 : クエスチョン・バンク医師国家試験問題解説 2017, 国試対策問題編集委員会編集メディックメディア, 東京, 2016年4月.
37.	早渕康信 : イヤーノート 2017: 内科・外科編「先天性心疾患・川崎病」, メディックメディア, 東京, 2016年3月.
38.	早渕康信 : 第110回医師国家試験問題解説国試対策問題編集委員会編, メディックメディア, 東京, 2016年3月.
39.	早渕康信 : 小児心電図診断基準徹底解説!心電図 -基礎から臨床まで- 森博愛・丸山徹編著, 医学出版社, 東京, 2015年10月.
40.	Yasunobu Hayabuchi : 第109回医師国家試験問題解説, メディックメディア, Tokyo, May 2015.
41.	早渕康信 : クエスチョン・バンク医師国家試験問題解説2016, メディックメディア, 2015年3月.
42.	早渕康信 : 「先天性心疾患・川崎病」イヤーノート2016, メディックメディア, 2015年3月.
43.	早渕康信 : 肺高血圧症 -主に肺動脈性肺高血圧症について - 小児疾患診療のための病態生理1 改訂第5版小児内科・小児外科編集委員会共編, 東京, 2014年12月.
44.	早渕康信 : 「気管挿管」小児科研修ノート改訂第2版, 株式会社診断と治療社, 東京, 2014年8月.
45.	早渕康信 : 第108回医師国家試験問題解説, メディックメディア, 東京, 2014年5月.
46.	早渕康信 : クエスチョン・バンク医師国家試験問題解説2015, メディックメディア, 2014年3月.
47.	早渕康信 : 「先天性心疾患・川崎病」イヤーノート2015, メディックメディア, 2014年3月.
48.	Yasunobu Hayabuchi, Miho Sakata, Tatsuya Ohnishi and Shoji Kagami : Chapter 5: Mechanical Stretch and Intermediate-Conductance Ca2+-Activated K+ Channels in Arterial Smooth Muscle Cells. In Mechanically Gated Channels and Their Regulatio Mechanosensitivity in Cells and Tissues Vol. 6 p159-188, 2012.
49.	Yasunobu Hayabuchi, Miki Inoue, Miho Sakata and Shoji Kagami : Multidetector-row computed tomography evaluation in congenital heart disease patients, --- Additional information to echocardiography and conventional cardiac catheterization. In Congenital Heart Defects: Etiology, Diagnosis and Treatment ---, Nova Science Publishers, 2009.

学術論文(審査論文):

1.	Chida-Nagai Ayako, Masaki Naoki, Maeda Kay, Sasaki Konosuke, Sato Hiroki, Muneuchi Jun, Ochiai Yoshie, Murayama Hiroomi, Tahara Masahiro, Shiono Atsuko, Shinozuka Atsushi, Kono Fumihiko, Machida Daisuke, Toyooka Shinichi, Sugimoto Seiichiro, Nakamura Kazufumi, Akagi Satoshi, Kondo Maiko, Kasahara Shingo, Kotani Yasuhiro, Koizumi Junichi, Oda Katsuhiko, Harada Masako, Nakajima Daisuke, Murata Akira, Nagata Hazumu, Yatsunami Koichi, Kobayashi Tomio, Matsunaga Yoshikiyo, Inoue Takahiro, Yamagishi Hiroyuki, Nakagawa Naomi, Ohtani Katsuki, Yamamoto Masaki, Ito Yushi, Hokosaki Tatsunori, Kuwahara Yuta, Masutani Satoshi, Nomura Koji, Wada Tsutomu, Sawada Hirofumi, Abiko Masayuki, Takahashi Tatsunori, Ishikawa Yuichi, Okada Seigo, Naitoh Atsushi, Toda Takako, Ando Tatsuya, Masuzawa Akihiro, Hoshino Shinsuke, Kawada Masaaki, Nomura Yuichi, Ueno Kentaro, Ohashi Naoki, Tachibana Tsuyoshi, Cao Yuchen, Ueda Hideaki, Yanagi Sadamitsu, Koide Masaaki, Mitsushita Norie, Higashi Kouji, Minosaki Yoshihiro, Hayashi Tomohiro, Okamoto Takashi, Kuraishi Kenji, Ehara Eiji, Ishida Hidekazu, Horigome Hitoshi, Murakami Takashi, Takei Kohta, Ishii Taku, Harada Gen, Hirata Yasutaka, Maeda Jun, Tatebe Shunsuke, Ota Chiharu, Yasunobu Hayabuchi, Sakazaki Hisanori, Sasaki Takashi, Hirono Keiichi, Suzuki Sayo, Yasuda Masahiro, Takeda Atsuhito, Sawai Madoka, Miyaji Kagami, Kitagawa Atsushi, Nakai Yosuke, Kakimoto Nobuyuki, Agematsu Kouta, Manabe Atsushi and Saiki Yoshikatsu : Use of the index of pulmonary vascular disease for predicting longterm outcome of pulmonary arterial hypertension associated with congenital heart disease, Frontiers in Cardiovascular Medicine, Vol.10, 1212882, 2023. (要約) Limited data exist on risk factors for the long-term outcome of pulmonary arterial hypertension (PAH) associated with congenital heart disease (CHD-PAH). We focused on the index of pulmonary vascular disease (IPVD), an assessment system for pulmonary artery pathology specimens. The IPVD classifies pulmonary vascular lesions into four categories based on severity: (1) no intimal thickening, (2) cellular thickening of the intima, (3) fibrous thickening of the intima, and (4) destruction of the tunica media, with the overall grade expressed as an additive mean of these scores. This study aimed to investigate the relationship between IPVD and the long-term outcome of CHD-PAH. This retrospective study examined lung pathology images of 764 patients with CHD-PAH aged <20 years whose lung specimens were submitted to the Japanese Research Institute of Pulmonary Vasculature for pulmonary pathological review between 2001 and 2020. Clinical information was collected retrospectively by each attending physician. The primary endpoint was cardiovascular death. The 5-year, 10-year, 15-year, and 20-year cardiovascular death-free survival rates for all patients were 92.0%, 90.4%, 87.3%, and 86.1%, respectively. The group with an IPVD of ≥2.0 had significantly poorer survival than the group with an IPVD <2.0 ( = .037). The Cox proportional hazards model adjusted for the presence of congenital anomaly syndromes associated with pulmonary hypertension, and age at lung biopsy showed similar results (hazard ratio 4.46; 95% confidence interval: 1.45-13.73; = .009). The IPVD scoring system is useful for predicting the long-term outcome of CHD-PAH. For patients with an IPVD of ≥2.0, treatment strategies, including choosing palliative procedures such as pulmonary artery banding to restrict pulmonary blood flow and postponement of intracardiac repair, should be more carefully considered. (出版サイトへのリンク) ● Publication site (DOI): 10.3389/fcvm.2023.1212882 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 37731527 ● Search Scopus @ Elsevier (PMID): 37731527 ● Search Scopus @ Elsevier (DOI): 10.3389/fcvm.2023.1212882 (DOI: 10.3389/fcvm.2023.1212882, PubMed: 37731527)
2.	Taichi Kato, Masaru Miura, Tohru Kobayashi, Tetsuji Kaneko, Naoya Fukushima, Kenji Suda, Jun Maeda, Shinya Shimoyama, Junko Shiono, Keiichi Hirono, Kazuyuki Ikeda, Seiichi Sato, Fujito Numano, Yoshihide MItani, Kenji Waki, Mamoru Ayusawa, Ryuji Fukazawa, Shigeto Fuse, Yasunobu Hayabuchi and Z-Score Study Stage 2nd Project Group : Analysis of Coronary Arterial Aneurysm Regression in Patients With Kawasaki Disease by Aneurysm Severity: Factors Associated With Regression., Journal of the American Heart Association, Vol.12, No.3, e022417, 2023. (要約) Background Coronary arterial aneurysms (CAAs) associated with Kawasaki disease (KD) significantly affect prognosis. However, the clinical course of CAAs and factors associated with CAA regression have not been well analyzed. Methods and Results The cohort of the Z-Score 2nd Project Stage study, a multicenter, retrospective, cohort study involving 44 institutions in Japan including 1006 patients with KD, was examined. CAAs were classified by the score of their internal diameter in the acute phase: small (<5), medium (5≤<10), and large (≥10). The lower limit of small CAA was based on the Japanese Ministry of Health, Labour and Welfare criteria. In the right coronary artery, the CAA regression rates 10 years after diagnosis were 95.5% for small, 83.2% for medium, and 36.3% for large. In the proximal left anterior descending artery, the regression rates 10 years after diagnosis were 95.3% for small, 80.1% for medium, and 28.8% for large. Cox regression analysis showed that diagnosis under the age of 1 year and onset of KD in 2010 to 2012 for the right coronary artery and the left anterior descending artery, and female for the right coronary artery were significantly associated with a high regression rate, whereas large CAAs for the right coronary artery and the left anterior descending artery were significantly associated with a low regression rate. Conclusions The current study, the largest Japanese study of its kind, found that small aneurysm, recent onset, and diagnosis under the age of 1 year predict regression, and that even giant aneurysms could regress. These data may contribute to long-term management of coronary aneurysms. Registration URL: https://www.umin.ac.jp/ctr/; Unique identifier: UMIN000010606. (キーワード) Humans / Female / Infant / Coronary Aneurysm / Coronary Vessels / Mucocutaneous Lymph Node Syndrome / Retrospective Studies / Cohort Studies (出版サイトへのリンク) ● Publication site (DOI): 10.1161/JAHA.121.022417 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 36718857 ● Search Scopus @ Elsevier (PMID): 36718857 ● Search Scopus @ Elsevier (DOI): 10.1161/JAHA.121.022417 (DOI: 10.1161/JAHA.121.022417, PubMed: 36718857)
3.	Hiroki Sato, Ken-ichi Suga, Masashi Suzue, Yukako Honma, Yasunobu Hayabuchi, Shunsuke Miyai, Hiroki Kurahashi and Ryuji Nakagawa : Novel large deletion involving EVC and EVC2 in Ellis-van Creveld syndrome, Human Genome Variation, Vol.9, No.1, 15, 2022. (要約) Ellis-van Creveld syndrome is an autosomal recessive skeletal dysplasia that is characterized by thoracic hypoplasia, polydactyly, oral abnormalities, and congenital heart disease. It is caused by pathogenic variants in the EVC or EVC2 genes. We report a case of a newborn with a compound heterozygous variant comprising NM_147127.5: c.1991dup:[p.Lys665Glufs*10] in the EVC2 gene and a novel large deletion involving exon 1 in EVC and exons 1-7 in EVC2. (徳島大学機関リポジトリ) ● Metadata: 118010 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41439-022-00190-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 35581188 ● Summary page in Scopus @ Elsevier: 2-s2.0-85130247944 (徳島大学機関リポジトリ: 118010, DOI: 10.1038/s41439-022-00190-0, PubMed: 35581188, Elsevier: Scopus)
4.	Koki Nagai, Tetsuya Niihori, Nobuhiko Okamoto, Akane Kondo, Ken-ichi Suga, Tokmoko Ohhira, Yasunobu Hayabuchi, Yukako Honma, Ryuji Nakagawa, Toshinobu Ifuku, Taiki Abe, Takeshi Mizuguchi, Naomichi Matsumoto and Yoko Aoki : Duplications in the G3 domain or switch II region in HRAS identified in patients with Costello syndrome., Human Mutation, Vol.43, No.1, 3-15, 2022. (要約) Costello syndrome (CS) is an autosomal-dominant disorder characterized by distinctive facial features, hypertrophic cardiomyopathy, skeletal abnormalities, intellectual disability, and predisposition to cancers. Germline variants in HRAS have been identified in patients with CS. Intragenic HRAS duplications have been reported in three patients with a milder phenotype of CS. In this study, we identified two known HRAS variants, p.(Glu63_Asp69dup), p.(Glu62_Arg68dup), and one novel HRAS variant, p.(Ile55_Asp57dup), in patients with CS, including a patient with craniosynostosis. These intragenic duplications are located in the G3 domain and the switch II region. Cells expressing cDNA with these three intragenic duplications showed an increase in ELK-1 transactivation. Injection of wild-type or mutant HRAS mRNAs with intragenic duplications in zebrafish embryos showed significant elongation of the yolk at 11 h postfertilization, which was improved by MEK inhibitor treatment, and a variety of developmental abnormalities at 3 days post fertilization was observed. These results indicate that small in-frame duplications affecting the G3 domain and switch II region of HRAS increase the activation of the ERK pathway, resulting in developmental abnormalities in zebrafish or patients with CS. (キーワード) Abnormalities, Multiple / Animals / Costello Syndrome / Humans / MAP Kinase Signaling System / Phenotype / Proto-Oncogene Proteins p21(ras) / Zebrafish (出版サイトへのリンク) ● Publication site (DOI): 10.1002/humu.24287 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 34618388 ● Summary page in Scopus @ Elsevier: 2-s2.0-85116783361 (DOI: 10.1002/humu.24287, PubMed: 34618388, Elsevier: Scopus)
5.	Yasunobu Hayabuchi, Yukako Honma and Shoji Kagami : Three-dimensional Imaging of Pulmonary Arterial Vasa Vasorum Using Optical Coherence Tomography in Patients After Bidirectional Glenn and Fontan Procedures, European Heart Journal Cardiovascular Imaging, Vol.22, No.8, 941-949, 2021. (要約) We evaluated pulmonary arterial (PA) vasa vasorum (VV) in Fontan candidate patients with a novel three-dimensional (3D) imaging technique using optical coherence tomography (OCT). This prospective study assessed the development of adventitial VV in the distal PA of 10 patients with bidirectional Glenn circulation (BDG group, 1.6 ± 0.3 years) and Fontan circulation (Fontan group, 3.3 ± 0.3 years), and in 20 children with normal PA haemodynamics and morphology (Control group, 1.5 ± 0.3 years). We assessed the PA VV with two-dimensional (2D) cross-sectional, multi-planar reconstruction (MPR), and volume rendering (VR) imaging. VV development was evaluated by the VV area/volume ratio, defined as the VV area/volume divided by the adventitial area/volume. Compared to the control group, the observed VV number and diameter on 3D images of MPR and VR were significantly higher, and curved and torturous-shaped VV were more frequently observed in the BDG and Fontan groups (P < 0.001, all). The median VV volume ratio was significantly greater in the BDG than in the control group (3.38% vs. 0.61%; P < 0.001). Although the VV volume ratio decreased significantly after the Fontan procedure (2.64%, P = 0.005 vs. BDG), the ratio remained higher than in the control group (P < 0.001 vs. control). 3D OCT imaging is a novel method that can be used to evaluate adventitial PA VV and may provide pathophysiological insight into the role of the PA VV in these patients. (キーワード) Fontan operation / bidirectional Glenn operation / optical coherence tomography / pulmonary artery / vasa vasorum (出版サイトへのリンク) ● Publication site (DOI): 10.1093/ehjci/jeaa098 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32413104 ● Search Scopus @ Elsevier (PMID): 32413104 ● Search Scopus @ Elsevier (DOI): 10.1093/ehjci/jeaa098 (DOI: 10.1093/ehjci/jeaa098, PubMed: 32413104)
6.	Issei Imoto, Masako Saito, Ken-ichi Suga, Tomohiro Kohmoto, Masanobu Ootsu, Keisuke Horiuchi, Hironao Nakayama, Shigeki Higashiyama, Mayumi Sugimoto, Ayumi Sasaki, Yukako Homma, Miki Shono, Ryuji Nakagawa, Yasunobu Hayabuchi, Shoichiro Tange, Shoji Kagami and Kiyoshi Masuda : Functionally confirmed compound heterozygous ADAM17 missense loss-of-function variants cause neonatal inflammatory skin and bowel disease 1., Scientific Reports, Vol.11, No.1, 2021. (要約) mEFs) exogenously expressing each of these mutants, phorbol 12-myristate 13-acetate-stimulated shedding was strongly reduced compared with wild-type ADAM17. Thus, in vitro functional assays demonstrated that both missense variants cause the loss-of-function of ADAM17, resulting in the development of NISBD1. Our study further expands the spectrum of genetic pathology underlying ADAM17 in NISBD1 and establishes functional assay systems for its missense variants. (徳島大学機関リポジトリ) ● Metadata: 116631 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-021-89063-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33953303 ● Search Scopus @ Elsevier (PMID): 33953303 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-021-89063-0 (徳島大学機関リポジトリ: 116631, DOI: 10.1038/s41598-021-89063-0, PubMed: 33953303)
7.	Yukako Honma and Yasunobu Hayabuchi : Descending aorta flow pattern in a neonate with patent ductus arteriosus coexisting with liver hemangioma., Journal of Echocardiography, 2021. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-021-00515-y (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33837505 ● Search Scopus @ Elsevier (PMID): 33837505 ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-021-00515-y (DOI: 10.1007/s12574-021-00515-y, PubMed: 33837505)
8.	Ken-ichi Suga, Issei Imoto, Hiromichi Ito, Takuya Naruto, Aya Gohji, Keita Osumi, Narumi Tokaji, Yukako Homma, Akemi Ono, Yuko Ichihara, Miki Shono, Tatsuo Mori, Maki Urushihara, Ryuji Nakagawa, Yasunobu Hayabuchi and Shoji Kagami : Next-generation sequencing for the diagnosis of patients with congenital multiple anomalies and / or intellectual disabilities, The Journal of Medical Investigation : JMI, Vol.67, No.3, 4, 246-249, 2020. (要約) Background : In clinical practice, a large proportion of patients with multiple congenital anomalies and/or intellectual disabilities (MCA / ID) lacks a specific diagnosis. Recently, next-generation sequencing (NGS) has become an efficient strategy for genetic diagnosis of patients with MCA/ID. To review the utility of NGS for the diagnosis of patients with MCA / ID. Patients with MCA/ID were recruited between 2013 and 2017. Molecular diagnosis was performed using NGS-based targeted panel sequencing for 4,813 genes. Promising causative variants underwent confirmation by Sanger sequencing or chromosomal microarray. Eighteen patients with MCA/ID were enrolled in this study. Of them, 8 cases (44%) were diagnosed by targeted panel sequencing. Most of diagnosed patients were able to receive better counseling and more appropriate medical management. NGS-based targeted panel sequencing seems to be an effective testing strategy for diagnosis of patients with MCA/ID. J. Med. Invest. 67 : 246-249, August, 2020. (キーワード) intellectual disability / multiple congenital anomalies / next-generation sequencing / targeted panel sequencing (徳島大学機関リポジトリ) ● Metadata: 115412 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.246 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33148896 ● Summary page in Scopus @ Elsevier: 2-s2.0-85095598029 (徳島大学機関リポジトリ: 115412, DOI: 10.2152/jmi.67.246, PubMed: 33148896, Elsevier: Scopus)
9.	Takatsuki Shinichi, Furutani Yoshiyuki, Inai Kei, Kobayashi Tohru, Inuzuka Ryo, Uyeda Tomomi, Kamisago Mitsuhiro, Muneuchi Jun, Kaneko Masahide, Misaki Yasushi, Ono Hiroshi, Kato Hitoshi, Shimada Eriko, Shinohara Tokuko, Waki Kenji, Suda Kenji, Yasunobu Hayabuchi, Ohki Hirotaka, Ishizaki Reina, Maeda Jun and Yamagishi Hiroyuki : Pregnancy and Delivery in Patients With Repaired Congenital Heart Disease - A Retrospective Japanese Multicenter Study, Circulation Journal, Vol.84, No.12, 2270-2274, 2020. (要約) Although advances in cardiac surgery have led to an increased number of survivors with congenital heart disease (CHD), epidemiological data regarding the pregnancies and deliveries of patients with repaired CHD are scarce.Methods and Results:In this study, we retrospectively reviewed the clinical outcomes of pregnancies and deliveries of women with repaired CHD. Overall, 131 women with repaired CHD were enrolled and there were 269 gestations. All patients were classified as New York Heart Association (NYHA) Class I or II. The prevalence of cesarean sections was higher in patients with (CyCHD) than without (AcyCHD) a past history of cyanosis (51% vs. 19%, respectively; P<0.01). There were 228 offspring from 269 gestations and the most prevalent neonatal complication was premature birth (10%), which was more frequent in the CyCHD than AcyCHD group (15.7% vs. 5.6%, respectively; P<0.01). Five maternal cardiac complications during delivery were observed only in the CyCHD group (8%); these were classified as NYHA Class II and none was fatal. Delivery was successful in most women with repaired CHD who were classified as NYHA Class I or II, although some with CyCHD and NYHA Class II required more attention. Cesarean sections were more common in the CyCHD than AcyCHD group, and CyCHD may be a potential risk for preterm deliveries. (キーワード) Adult congenital heart disease / Cesarean section / Premature / Tetralogy of Fallot (徳島大学機関リポジトリ) ● Metadata: 118041 (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-19-1150 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 33055459 ● Summary page in Scopus @ Elsevier: 2-s2.0-85096885860 (徳島大学機関リポジトリ: 118041, DOI: 10.1253/circj.CJ-19-1150, PubMed: 33055459, Elsevier: Scopus)
10.	Yukako Homma and Yasunobu Hayabuchi : Successful treatment by stent implantation for systemic-to-pulmonary shunt obstruction due to a Staphylococcus aureus abscess: A case report, Cardiology in the Young, Vol.30, No.10, 1538-1540, 2020. (要約) A 13-year-old girl with a single ventricle and bilateral systemic-to-pulmonary shunts developed hypoxia due to shunt stenosis, which was caused by a methicillin-sensitive Staphylococcus aureus abscess. Stent implantation associated with appropriate antibiotic administration was crucial to dilate and maintain shunt patency. (キーワード) Staphylococcus aureus / Stent implantation / abscess / systemicpulmonary shunt (出版サイトへのリンク) ● Publication site (DOI): 10.1017/S1047951120002565 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32807253 ● Summary page in Scopus @ Elsevier: 2-s2.0-85093538908 (DOI: 10.1017/S1047951120002565, PubMed: 32807253, Elsevier: Scopus)
11.	Keita Osumi, Ken-ichi Suga, Akemi Ono, Aya Gohji, Tatsuo Mori, Yukiko Kinoshita, Mikio Sugano, Yoshihiro Touda, Maki Urushihara, Ryuji Nakagawa, Yasunobu Hayabuchi, Issei Imoto and Shoji Kagami : Molecular diagnosis of an infant with TSC2/ PKD1 contiguous gene syndrome, Human Genome Variation, Vol.7, No.21, 2020. (要約) A 1-month-old Japanese infant with cardiac rhabdomyoma was diagnosed with / contiguous gene syndrome by targeted panel sequencing with subsequent quantitative polymerase chain reaction that revealed gross monoallelic deletion, including parts of two genes: exons 19-42 of and exons 2-46 of . Early molecular diagnosis can help to detect bilateral renal cyst formation and multidisciplinary follow-up of this multisystem disease. (徳島大学機関リポジトリ) ● Metadata: 116193 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41439-020-0108-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32695431 ● Summary page in Scopus @ Elsevier: 2-s2.0-85088011488 (徳島大学機関リポジトリ: 116193, DOI: 10.1038/s41439-020-0108-0, PubMed: 32695431, Elsevier: Scopus)
12.	Akemi Ono, Yasunobu Hayabuchi, Manami Tanaka and Shoji Kagami : Assessment of Right Ventricular Function by Isovolumic Acceleration of Pulmonary and Tricuspid Annulus in Surgically Repaired Tetralogy of Fallot, The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 145-150, 2020. (要約) Assessment of right ventricular (RV) function is quite important in patients with surgically corrected tetralogy of Fallot (TOF). However, quantitative assessment of RV function remains challenging, mainly because of the complex RV geometry. This prospective study investigated isovolumic acceleration (IVA), a parameter of myocardial systolic function not influenced by either preload or afterload, using tissue Doppler imaging. We evaluated IVA measured on pulmonary annulus (PA-IVA) and tricuspid annulus (TA-IVA), because we considered that PA-IVA and TA-IVA correspond with systolic function of the RV outflow tract (RVOT) and RV basal function, respectively. Thirty-nine patients with surgically repaired TOF (TOF group) and 40 age-matched healthy children (control group) were enrolled in this study. No significant difference was seen between TA-IVA (2.5 ± 0.8 m/s2) and PA-IVA (2.4 ± 0.8 m/s2) in the control group. In the TOF group, PA-IVA (1.0 ± 0.5 m/s2) was significantly lower than TA-IVA (1.3 ± 0.6 m/s2, p < 0.05). Both TA-IVA and PA-IVA were significantly lower in the TOF group than in the control group (p < 0.05 each). We concluded that PA-IVA offers a useful index to assess RVOT function in TOF patients. J. Med. Invest. 67 : 145-150, February, 2020. (キーワード) isovolumic acceleration / right ventricular function / pulmonary annulus / terralogy of Fallot (徳島大学機関リポジトリ) ● Metadata: 114735 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.145 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378598 ● Summary page in Scopus @ Elsevier: 2-s2.0-85084328907 (徳島大学機関リポジトリ: 114735, DOI: 10.2152/jmi.67.145, PubMed: 32378598, Elsevier: Scopus)
13.	Yasunobu Hayabuchi, Yukako Honma and Shoji Kagami : A novel index equivalent to the myocardial performance index for right ventricular functional assessment in children and adolescent patients., Scientific Reports, Vol.9, No.1, 19975, 2019. (要約) The aims of the present study were to develop and check the utility and feasibility of a novel right ventricular (RV) functional index (RV angular velocity; RVω, s) derived from the angular velocity in harmonic oscillator kinematics obtained from the RV pressure waveform. We hypothesized that RVω reflects the myocardial performance index (MPI), which represents global RV function. A total of 132 consecutive patients, ranging in age from 3 months to 34 years with various cardiac diseases were included in this prospective study. RVω was defined as the difference between the peak derivative of pressure (dP/dt_max - dP/dt_min) divided by the difference between the maximum and minimum pressure (Pmax - Pmin). RVω showed significant negative correlations with the pulsed-wave Doppler-derived myocardial performance index (PWD-MPI) and the tissue Doppler imaging-derived MPI (TDI-MPI) (r = -0.52 and -0.51, respectively; both p < 0.0001). RVω also showed significant positive correlations with RV fractional area change (RVFAC) and RV ejection fraction (RVEF) (r = 0.41 and 0.39, respectively; both p < 0.0001), as well as a significant negative correlation with tricuspid E/e' (r = -0.19, p = 0.0283). The clinical feasibility and utility of RVω for assessing global RV performance, incorporating both systolic and diastolic function, were demonstrated. (徳島大学機関リポジトリ) ● Metadata: 114128 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/s41598-019-56564-y (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31882794 ● Search Scopus @ Elsevier (PMID): 31882794 ● Search Scopus @ Elsevier (DOI): 10.1038/s41598-019-56564-y (徳島大学機関リポジトリ: 114128, DOI: 10.1038/s41598-019-56564-y, PubMed: 31882794)
14.	Yasunobu Hayabuchi, Yukako Homma and Shoji Kagami : Right Ventricular Myocardial Stiffness and Relaxation Components by Kinematic Model-Based Transtricuspid Flow Analysis in Children and Adolescents with Pulmonary Arterial Hypertension., Ultrasound in Medicine & Biology, Vol.45, No.8, 1999-2009, 2019. (要約) We hypothesized that the kinematic model-based parameters obtained from the transtricuspid E-wave would be useful for evaluating the right ventricular diastolic property in pediatric pulmonary arterial hypertension (PAH) patients. The model was parametrized by stiffness/elastic recoil k, relaxation/damping c and load x. These parameters were determined as the solution of m dx/dt + c dx/dt + kx = 0, which is based on the theory that the E-wave contour is determined by the interplay of stiffness/restoring force, damping/relaxation force and load. The PAH group had a significantly higher k and c compared with the control group (182.5 72.4 g/s vs. 135.7 49.5 g/s, p = 0.0232, and 21.9 6.5 g/s vs. 10.6 5.2 g/s, p <0.0001, respectively). These results indicate that in the PAH group, the right ventricle had higher stiffness/elastic recoil and inferior cross-bridge relaxation. The present findings indicate the feasibility and utility of using kinematic model parameters to assess right ventricular diastolic function. (徳島大学機関リポジトリ) ● Metadata: 113964 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ultrasmedbio.2019.04.021 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 31122811 ● Search Scopus @ Elsevier (PMID): 31122811 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ultrasmedbio.2019.04.021 (徳島大学機関リポジトリ: 113964, DOI: 10.1016/j.ultrasmedbio.2019.04.021, PubMed: 31122811)
15.	Yasunobu Hayabuchi, Yukako Homma and Shoji Kagami : Optical coherence tomography for observing development of pulmonary arterial vasa vasorum after bidirectional cavopulmonary connection in children., PLoS ONE, Vol.14, No.4, e0215146, 2019. (要約) Hypoxia and low pulmonary arterial (PA) blood flow stimulate the development of systemic-to-pulmonary collateral blood vessels, which can be an adverse factor when performing the Fontan operation. The aim of this study was to use optical coherence tomography (OCT) to elucidate the morphological changes in PA vasculature after creation of a bidirectional cavopulmonary connection (BCPC) in children. This prospective study evaluated PA wall thickness and development of PA vasa vasorum (VV) in the distal PA of eight patients (BCPC group, 1.3 0.3 years) and 20 age-matched children with normal pulmonary artery hemodynamics and morphology (Control group, 1.4 0.3 years). VV development was defined by the VV area ratio, defined as the VV area divided by the adventitial area in cross-sectional images. There was no significant difference in PA wall thickness between the BCPC and control groups (0.12 0.03 mm vs. 0.12 0.02 mm, respectively). The VV area ratio was significantly greater in the BCPC group than in the Control group (14.5 3.5% vs. 5.3 1.6%, respectively; p<0.0001). OCT is a promising new tool for evaluating PA pathology, including the development of VV in patients after BCPC. (徳島大学機関リポジトリ) ● Metadata: 113963 (出版サイトへのリンク) ● Publication site (DOI): 10.1371/journal.pone.0215146 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30958848 ● Search Scopus @ Elsevier (PMID): 30958848 ● Search Scopus @ Elsevier (DOI): 10.1371/journal.pone.0215146 (徳島大学機関リポジトリ: 113963, DOI: 10.1371/journal.pone.0215146, PubMed: 30958848)
16.	Yasunobu Hayabuchi : Developing therapeutic methods for the prevention of progressive pulmonary arterial remodelling and treatment of right ventricular heart failure., Impact, Vol.2019, No.4, 16-19, 2019. (徳島大学機関リポジトリ) ● Metadata: 113962 (出版サイトへのリンク) ● Publication site (DOI): 10.21820/23987073.2019.4.16 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.21820/23987073.2019.4.16 (徳島大学機関リポジトリ: 113962, DOI: 10.21820/23987073.2019.4.16)
17.	Yasunobu Hayabuchi, Yukako Homma, Mikio Sugano, Takashi Kitaichi and Shoji Kagami : Development of acquired intrapulmonary venous anastomosis contributing to establishment of Fontan circulation., Pulmonary Circulation, Vol.9, No.1, 2045894018814774, 2018. (要約) Pulmonary venous (PV) obstruction is associated with a poor prognosis, as well as a high risk of recurrence, following surgical treatment. It can also interfere with the successful completion of Fontan circulation in patients with complex congenital heart disease. A case of a patient who had right isomerism (also known as asplenia syndrome), total anomalous pulmonary venous connection (TAPVC), and a single right ventricle is presented. Although bilateral total occlusion of the inferior PVs was identified postoperatively, the formation of the anastomosis and collateral vessels into the superior and middle PVs enabled successful completion of Fontan circulation. Anastomoses and collateral flow of the PVs were found largely in the interlobar pleura and not in the lung parenchyma. (徳島大学機関リポジトリ) ● Metadata: 113961 (出版サイトへのリンク) ● Publication site (DOI): 10.1177/2045894018814774 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 30419793 ● Summary page in Scopus @ Elsevier: 2-s2.0-85064829790 (徳島大学機関リポジトリ: 113961, DOI: 10.1177/2045894018814774, PubMed: 30419793, Elsevier: Scopus)
18.	Yukako Homma, Yasunobu Hayabuchi, Akemi Ono and Shoji Kagami : Pulmonary Artery Wall Thickness Assessed by Optical Coherence Tomography Correlates With Pulmonary Hemodynamics in Children With Congenital Heart Disease., Circulation Journal, Vol.82, No.9, 2350-2357, 2018. (要約) Pulmonary arterial (PA) wall thickening evaluated by optical coherence tomography (OCT) has been reported in adults with PA hypertension. The purpose of this study was to evaluate the feasibility of OCT for preoperative assessment of the PA wall in children with congenital heart disease (CHD). Methods and esults: Participants comprised 39 patients with ventricular septal defect, atrial septal defect, or patent ductus arteriosus. Attempts were made to evaluate vessels of various diameters using OCT. Clearly observed vessels that were optimal for evaluation were selected and classified into 4 subgroups by diameter of the lumen. Optimal depiction was obtained in 80 of 156 vessels in total, and 25 (64.1%), 34 (87.1%), 17 (43.6%), and 4 vessels (10.3%) in each of the 1.0-<2.0 mm, 2.0-<3.0 mm, 3.0-<4.0 mm, and 4.0-5.0 mm subgroups, respectively. Arterial walls in the 2.0-<3.0 mm subgroup were the most frequently delineated, and wall thickness correlated significantly with mean PA pressure, pulmonary vascular resistance index, pulmonary-to-systemic flow ratio, and PA capacitance index (r=0.56, 0.52, 0.37, and -0.49, respectively). The 3-layered appearance was delineated in 29 of 80 vessels (36.2%). This feature had no significant correlation with pulmonary hemodynamics. OCT represents a promising tool for evaluating the PA wall in children with CHD. (徳島大学機関リポジトリ) ● Metadata: 113960 (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-18-0379 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29998931 ● Search Scopus @ Elsevier (PMID): 29998931 ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-18-0379 (徳島大学機関リポジトリ: 113960, DOI: 10.1253/circj.CJ-18-0379, PubMed: 29998931)
19.	小野朱美, 早渕康信, 香美祥二, 森一博 : 右室圧負荷は僧帽弁のtethering を増悪させる:内科的加療のみで軽快した重症僧帽弁狭窄兼閉鎖不全の1乳児例の考察, 日本小児循環器学会雑誌, Vol.34, No.4, 215-221, 2018年. (徳島大学機関リポジトリ) ● Metadata: 113959 (出版サイトへのリンク) ● Publication site (DOI): 10.9794/jspccs.34.215 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9794/jspccs.34.215 (徳島大学機関リポジトリ: 113959, DOI: 10.9794/jspccs.34.215)
20.	Yasunobu Hayabuchi, Ono Akemi, Homma Yukako and Shoji Kagami : Analysis of Right Ventricular Myocardial Stiffness and Relaxation Components in Children and Adolescents With Pulmonary Arterial Hypertension., Journal of the American Heart Association, Vol.7, No.9, e008670, 2018. (要約) The rate of left ventricular pressure decrease during isovolumic relaxation is traditionally assessed algebraically via 2 empirical indices: the monoexponential and logistic time constants (τ and τ). Since the pattern of right ventricular (RV) pressure decrease is quite different from that of the left ventricular, we hypothesized that novel kinematic model parameters are more appropriate and useful to evaluate RV diastolic dysfunction. Eight patients with pulmonary arterial hypertension (age 12.5±4.8 years) and 20 normal subjects (control group; age 12.3±4.4 years) were enrolled. The kinematic model was parametrized by stiffness/restoring Ek and damping/relaxation μ. The model predicts isovolumic relaxation pressure as a function of time as the solution of dP/dt+(1/μ)dP/dt+EkP=0, based on the theory that the pressure decay is determined by the interplay of inertial, stiffness/restoring, and damping/relaxation forces. In the assessment of RV diastolic function, τ and τ did not show significant differences between the pulmonary arterial hypertension and control groups (46.8±15.5 ms versus 32.5±14.6 ms, and 19.6±5.9 ms versus 14.5±7.2 ms, respectively). The pulmonary arterial hypertension group had a significantly higher Ek than the control group (915.9±84.2 s versus 487.0±99.6 s, <0.0001) and a significantly lower μ than the control group (16.5±4.3 ms versus 41.1±10.4 ms, <0.0001). These results show that the RV has higher stiffness/elastic recoil and lower cross-bridge relaxation in pulmonary arterial hypertension. The present findings indicate the feasibility and utility of kinematic model parameters for assessing RV diastolic function. (徳島大学機関リポジトリ) ● Metadata: 113033 (出版サイトへのリンク) ● Publication site (DOI): 10.1161/JAHA.118.008670 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29674337 ● Search Scopus @ Elsevier (PMID): 29674337 ● Search Scopus @ Elsevier (DOI): 10.1161/JAHA.118.008670 (徳島大学機関リポジトリ: 113033, DOI: 10.1161/JAHA.118.008670, PubMed: 29674337)
21.	Miura Masaru, Kobayashi Tohru, Kaneko Tetsuji, Ayusawa Mamoru, Fukazawa Ryuji, Fukushima Naoya, Fuse Shigeto, Hamaoka Kenji, Hirono Keiichi, Kato Taichi, Mitani Yoshihide, Sato Seiichi, Shimoyama Shinya, Shiono Junko, Suda Kenji, Suzuki Hiroshi, Maeda Jun, iWaki Kenj, Kato Hitoshi, Saji Tsutomu, Yamagishi Hiroyuki, Ozeki Aya, Tomotsune Masako, Yoshida Makiko, Akazawa Yohei, Aso Kentaro, Doi Shouzaburoh, Fukasawa Yoshi, Furuno Kenji, Yasunobu Hayabuchi, Hayashi Miyuki, Honda Takafumi, Horita Norihisa, Ikeda Kazuyuki, Ishii Masahiro, Iwashima Satoru, Kamada Masahiro, Kaneko Masahide, Katyama Hiroshi, Kawamura Yoichi, Kitagawa Atushi, Komori Akiko, Kuraishi Kenji, Masuda Hiroshi, Matsuda Shinichi, Matsuzaki Satoshi, Mii Sayaka, Miyamoto Tomoyuki, Moritou Yuji, Motoki Noriko, Nagumo Kiyoshi, Nakamura Tsuneyuki, Nishihara Eiki, Nomura Yuichi, Ogata Shohei, Ohashi Hiroyuki, Okumura Kenichi, Omori Daisuke, Sano Tetsuya, Suganuma Eisuke, Takahashi Tsutomu, Takatsuki Shinichi, Takeda Atsuhito, Terai Masaru, Toyono Manatomo, Watanabe Kenichi, Watanabe Makoto, Yamamoto Masaki and Yamamura Kenichiro : Association of Severity of Coronary Artery Aneurysms in Patients With Kawasaki Disease and Risk of Later Coronary Events, JAMA Pediatrics, e180030, 2018. (要約) Few studies with sufficient statistical power have shown the association of the z score of the coronary arterial internal diameter with coronary events (CE) in patients with Kawasaki disease (KD) with coronary artery aneurysms (CAA). To clarify the association of the z score with time-dependent CE occurrence in patients with KD with CAA. This multicenter, collaborative retrospective cohort study of 44 participating institutions included 1006 patients with KD younger than 19 years who received a coronary angiography between 1992 and 2011. The time-dependent occurrence of CE, including thrombosis, stenosis, obstruction, acute ischemic events, and coronary interventions, was analyzed for small (z score, <5), medium (z score, ≥5 to <10; actual internal diameter, <8 mm), and large (z score, ≥10 or ≥8 mm) CAA by the Kaplan-Meier method. The Cox proportional hazard regression model was used to identify risk factors for CE after adjusting for age, sex, size, morphology, number of CAA, resistance to initial intravenous immunoglobulin (IVIG) therapy, and antithrombotic medications. Of 1006 patients, 714 (71%) were male, 341 (34%) received a diagnosis before age 1 year, 501 (50%) received a diagnosis between age 1 and 5 years, and 157 (16%) received a diagnosis at age 5 years or older. The 10-year event-free survival rate for CE was 100%, 94%, and 52% in men (P < .001) and 100%, 100%, and 75% in women (P < .001) for small, medium, and large CAA, respectively. The CE-free rate was 100%, 96%, and 79% in patients who were not resistant to IVIG therapy (P < .001) and 100%, 96%, and 51% in patients who were resistant to IVIG therapy (P < .001), respectively. Cox regression analysis revealed that large CAA (hazard ratio, 8.9; 95% CI, 5.1-15.4), male sex (hazard ratio, 2.8; 95% CI, 1.7-4.8), and resistance to IVIG therapy (hazard ratio, 2.2; 95% CI, 1.4-3.6) were significantly associated with CE. Classification using the internal diameter z score is useful for assessing the severity of CAA in relation to the time-dependent occurrence of CE and associated factors in patients with KD. Careful management of CE is necessary for all patients with KD with CAA, especially men and IVIG-resistant patients with a large CAA. (出版サイトへのリンク) ● Publication site (DOI): 10.1001/jamapediatrics.2018.0030 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29507955 ● Search Scopus @ Elsevier (PMID): 29507955 ● Search Scopus @ Elsevier (DOI): 10.1001/jamapediatrics.2018.0030 (DOI: 10.1001/jamapediatrics.2018.0030, PubMed: 29507955)
22.	Yasunobu Hayabuchi, Akemi Ono, Yukako Homma and Shoji Kagami : Pulmonary annular motion velocity reflects right ventricular outflow tract function in children with surgically repaired congenital heart disease, Heart and Vessels, Vol.33, No.3, 316-326, 2018. (要約) Right ventricular (RV) dysfunction is generally evaluated using analyses of tricuspid annular motion. However, it represents only one aspect of RV performance. Whether measuring pulmonary annular motion velocity could serve as a novel way to evaluate global RV and/or RV outflow tract (RVOT) performance in pediatric congenital heart disease (CHD) patients with surgically repaired RVOT was evaluated. In this prospective study, tissue Doppler-derived pulmonary annular motion velocity was measured in children (aged 2-5 years) with RVOT reconstruction (RVOTR group, n = 48) and age-matched healthy children (Control, n = 60). The types of RVOTR procedures were as follows: pulmonary valve-sparing procedure (PVS, n = 7); transannular patch with monocusp valve reconstruction (TAP, n = 29); and RV-to-PA conduit reconstruction using a pericardial valve with expanded polytetrafluoroethylene conduit (Rastelli, n = 12). Pulmonary annular motion velocity waveforms comprised systolic bimodal (s1' and s2') and diastolic e' and a' waves in all participants. The peak velocities of s1', s2', e', and a' were significantly lower in the RVOTR group than in the control group (all p < 0.0001). Furthermore, these parameters depended significantly on the type of surgical procedure. The peak velocities of s1', s2', and e' had significant correlations with RVOT ejection fraction (RVOT-EF) (r = 0.56, 0.49, and 0.34, respectively), and RVOT fractional shortening (RVOT-FS) (r = 0.72, 0.55, and 0.41, respectively), although there were no significant correlations between pulmonary annular motion and global RV function, including RV ejection fraction (RVEF) and RV fractional area change (RVFAC) in the assessment of all RVOTR group patients. The pulmonary annular motion parameters in the PVS group had significant correlations with both global RV and RVOT performance. The TAP group showed significant correlations between RVOT function and pulmonary annular motion. The Rastelli group showed almost no significant correlations between RV/RVOT function and tissue Doppler parameters. Pulmonary annular motion velocity is a simple, rapid, reproducible, and useful method of assessing RVOT function in children with surgically repaired CHD. (徳島大学機関リポジトリ) ● Metadata: 113957 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00380-017-1061-9 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29026988 ● Search Scopus @ Elsevier (PMID): 29026988 ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-017-1061-9 (徳島大学機関リポジトリ: 113957, DOI: 10.1007/s00380-017-1061-9, PubMed: 29026988)
23.	Yukako Homma, Yasunobu Hayabuchi, Tomohisa Terada, Miki Inoue and Kazuhiro Mori : Early Diastolic Left Ventricular Relaxation in Normal Neonates is Influenced by Ventricular Stiffness and Longitudinal Systolic Function., International Heart Journal, Vol.59, No.1, 149-153, 2018. (要約) Tissue Doppler velocity during early diastole (e') is one of the most feasible and reproducible echocardiographic assessments to reflect active relaxation of the left ventricle. Although several reports have described the mechanisms of temporal diastolic dysfunction in the early neonatal period, factors influencing diastolic function have not been determined. The purpose of this study was to elucidate factors significantly influencing e' in the early neonatal period.A total of 179 consecutive normal neonates underwent echocardiographic studies performed at 0 days and 5-10 days after birth. The statistical relationships between e' and age, body weight, mean blood pressure, heart rate, shortening fraction of the left ventricle, peak systolic motion velocity (s'), early diastolic transmitral flow velocity over annulus velocity, Tei index, and diastolic wall strain (DWS) were analyzed.Between the 0 days and 5-10-days-after birth groups, significant differences were shown in mean blood pressure, shortening fraction of left ventricle, e', and Tei index. Age, body weight, mean blood pressure, s', and DWS showed significant correlations with e'. In multivariate regression analysis within these parameters, s' (β = 0.6119, P < 0.0001) and DWS (β = 0.1216, P = 0.0321) showed positive correlations with e'.Longitudinal systolic motion velocity and ventricular wall stiffness of the left ventricle influence diastolic relaxation in normal neonates. Age, body weight, and circumferential systolic function are not significant factors. (キーワード) Blood Flow Velocity / Diastole / Early Diagnosis / Echocardiography, Doppler / Feasibility Studies / Female / Heart Ventricles / Humans / Infant, Newborn / Male / Mitral Valve / Regional Blood Flow / Reproducibility of Results / Systole / Ventricular Dysfunction, Left / Ventricular Function, Left (徳島大学機関リポジトリ) ● Metadata: 113956 (出版サイトへのリンク) ● Publication site (DOI): 10.1536/ihj.17-125 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 29332921 ● Search Scopus @ Elsevier (PMID): 29332921 ● Search Scopus @ Elsevier (DOI): 10.1536/ihj.17-125 (徳島大学機関リポジトリ: 113956, DOI: 10.1536/ihj.17-125, PubMed: 29332921)
24.	Aya Shirakawa, Takashi Kaji, Yasunobu Hayabuchi, Souichiro Nakayama, Kazuhisa Maeda and Minoru Irahara : Prenatal three-dimensional color Doppler imaging showing crossover of the inflow streams of two ventricles in a case of criss-cross heart., Journal of Echocardiography, Vol.15, No.4, 191-193, 2017. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-017-0339-3 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28484959 ● Search Scopus @ Elsevier (PMID): 28484959 ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-017-0339-3 (DOI: 10.1007/s12574-017-0339-3, PubMed: 28484959)
25.	Yasunobu Hayabuchi, Akemi Ono, Yukako Homma and Shoji Kagami : Temporal Sequential Pattern of Right Ventricular Free Wall Contraction in Normal Children., Circulation Journal, Vol.81, No.11, 1699-1706, 2017. (要約) The temporal sequence of right ventricular (RV) deformation is related to RV dysfunction. The sequence of RV free wall contraction was investigated.Methods and Results:In this prospective study, strain profiles using speckle-tracking echocardiography and tissue Doppler-derived pulmonary and tricuspid annular motion were assessed in 60 normal children. Circumferential RV free wall strain of 3 individual segments (anterior, lateral, and inferior) was evaluated. Longitudinal strain was assessed in 3 individual segments (RV outflow tract [RVOT], apical, and RV inflow tract [RVIT]). The isovolumetric contraction time (ICT) and the time interval between the onset of the QRS wave to the peak s' wave were measured for pulmonary and tricuspid annular motion velocities. The time to peak circumferential strain was significantly lower in the anterior than in the lateral and inferior segments (339.1±19.5, 358.3±21.8, and 366.6±22.4 ms, respectively; P<0.0001). Longitudinal deformation of the RVOT segment occurred before the apical and RVIT segments (351.8±23.1, 366.3±20.1, and 369.2±21.3 ms, respectively; P<0.0001). The ICT and the time to peak s' were significantly shorter in pulmonary than in tricuspid annular motion (49.4±10.1 vs 58.0±13.2 ms; and 104.7±12.2 vs. 160.5±27.1 ms; P<0.0001 for each). Longitudinal deformation of RVOT precedes RVIT. Circumferential deformation occurs in the anterior segment before the lateral and posterior segments. The presence of mechanical time heterogeneity appears important for RV performance. (キーワード) Child, Preschool / Echocardiography / Humans / Infant / Myocardial Contraction / Prospective Studies / Pulmonary Valve / Time Factors / Tricuspid Valve / Ventricular Function, Right (徳島大学機関リポジトリ) ● Metadata: 113954 (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-17-0273 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28592727 ● Search Scopus @ Elsevier (PMID): 28592727 ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-17-0273 (徳島大学機関リポジトリ: 113954, DOI: 10.1253/circj.CJ-17-0273, PubMed: 28592727)
26.	Ce Wang, Yukiko Hata, Keiichi Hirono, Asami Takahashi and Yasunobu Hayabuchi : A wide and specific spectrum of genetic variants and genotype? Phenotype correlations revealed by next-generation sequencing in patients with left ventricular noncompaction., Journal of the American Heart Association, Vol.6, No.9, e006210, 2017. (要約) Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patients. Using next-generation sequencing, we targeted and sequenced 73 genes related to cardiomyopathy in 102 unrelated LVNC patients. We identified 43 pathogenic variants in 16 genes in 39 patients (38%); 28 were novel variants. Sarcomere gene variants accounted for 63%, and variants in genes associated with channelopathies accounted for 12%. and pathogenic variants were the most common, and rare variant collapsing analysis showed variants in these genes contributed to the risk of LVNC, although patients carrying and pathogenic variants displayed different phenotypes. Patients with pathogenic variants had early age of onset and more severely decreased left ventricular ejection fractions. Survival analysis showed poorer prognosis in patients with pathogenic variants, especially those with multiple variants: All died before their first birthdays. Adverse events were noted in 17 patients, including 13 deaths, 3 heart transplants, and 1 implantable cardioverter-defibrillator insertion. Congestive heart failure at diagnosis and pathogenic variants were independent risk factors for these adverse events. Next-generation sequencing revealed a wide spectrum of genetic variations and a high incidence of pathogenic variants in LVNC patients. These pathogenic variants were independent risk factors for adverse events. Patients harboring pathogenic variants showed poor prognosis and should be followed closely. (キーワード) Child, Preschool / DNA Mutational Analysis / Defibrillators, Implantable / Disease-Free Survival / Electric Countershock / Female / Gene Frequency / Genetic Association Studies / Genetic Markers / Genetic Predisposition to Disease / Heart Transplantation / High-Throughput Nucleotide Sequencing / Humans / Infant / Isolated Noncompaction of the Ventricular Myocardium / Japan / Kaplan-Meier Estimate / Male / Mutation / Phenotype / Polymorphism, Single Nucleotide / Predictive Value of Tests / Time Factors / Ventricular Function, Left (徳島大学機関リポジトリ) ● Metadata: 113953 (出版サイトへのリンク) ● Publication site (DOI): 10.1161/JAHA.117.006210 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28855170 ● Search Scopus @ Elsevier (PMID): 28855170 ● Search Scopus @ Elsevier (DOI): 10.1161/JAHA.117.006210 (徳島大学機関リポジトリ: 113953, DOI: 10.1161/JAHA.117.006210, PubMed: 28855170)
27.	Yasunobu Hayabuchi, Akemi Ono, Yukako Homma and Shoji Kagami : Assessment of pulmonary arterial compliance evaluated using harmonic oscillator kinematics., Pulmonary Circulation, Vol.7, No.3, 666-673, 2017. (要約) We hypothesized that K, a harmonic oscillator kinematics-derived spring constant parameter of the pulmonary artery pressure (PAP) profile, reflects PA compliance in pediatric patients. In this prospective study of 33 children (age range = 0.5-20 years) with various cardiac diseases, we assessed the novel parameter designated as Kcalculated using the pressure phase plane and the equation K = (dP/dt_max)/([Pmax - Pmin])/2), where dP/dt_max is the peak derivative of PAP, and Pmax - Pmin is the difference between the minimum and maximum PAP. PA compliance was also calculated using two conventional methods: systolic PA compliance (sPAC) was expressed as the stroke volume/Pmax - Pmin; and diastolic PA compliance (dPAC) was determined according to a two-element Windkessel model of PA diastolic pressure decay. In addition, data were recorded during abdominal compression to determine the influence of preload on K. A significant correlation was observed between Kand sPAC (r = 0.52, P = 0.0018), but not dPAC. Significant correlations were also seen with the time constant (τ) of diastolic PAP (r = -0.51, P = 0.0026) and the pulmonary vascular resistance index (r = -0.39, P = 0.0242). No significant difference in Kwas seen between before and after abdominal compression. Khad a higher intraclass correlation coefficient than other compliance and resistance parameters for both intra-observer and inter-observer variability (0.998 and 0.997, respectively). These results suggest that Kcan provide insight into the underlying mechanisms and facilitate the quantification of PA compliance. (徳島大学機関リポジトリ) ● Metadata: 113952 (出版サイトへのリンク) ● Publication site (DOI): 10.1177/2045893217714781 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28621582 ● Search Scopus @ Elsevier (PMID): 28621582 ● Search Scopus @ Elsevier (DOI): 10.1177/2045893217714781 (徳島大学機関リポジトリ: 113952, DOI: 10.1177/2045893217714781, PubMed: 28621582)
28.	Yasunobu Hayabuchi : The Action of Smooth Muscle Cell Potassium Channels in the Pathology of Pulmonary Arterial Hypertension., Pediatric Cardiology, Vol.38, No.1, 1-14, 2017. (徳島大学機関リポジトリ) ● Metadata: 113951 (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00246-016-1491-7 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27826710 ● Search Scopus @ Elsevier (PMID): 27826710 ● Search Scopus @ Elsevier (DOI): 10.1007/s00246-016-1491-7 (徳島大学機関リポジトリ: 113951, DOI: 10.1007/s00246-016-1491-7, PubMed: 27826710)
29.	Takashi Kaji, Yasunobu Hayabuchi, Kazuhisa Maeda, Soichiro Nakayama and Minoru Irahara : Prenatal assessment of coronary artery anatomy using color Doppler in cases of D-transposition of the great arteries: Case reports, The Journal of Obstetrics and Gynaecology Research, Vol.43, No.2, 397-402, 2017. (要約) Abnormal coronary artery (CA) anatomy is common in cases of D-transposition of the great arteries (TGA) and can be a significant risk factor during the arterial switch operation. Here, we report three cases of TGA in which CA anatomy was assessed prenatally using color Doppler imaging. All CA, except the left circumflex CA in one case, were identified. CA anatomy was completely correctly diagnosed in one of our three cases. In the two remaining cases, the left circumflex CA could not be visualized in one patient, and the origin of the left anterior descending CA was not correctly diagnosed in the other. We found that prenatal assessment of CA anatomy using color Doppler in TGA was feasible, but the diagnostic accuracy was limited. We anticipate that more experience with the advancing technology will improve accuracy. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/jog.13214 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28150404 ● Search Scopus @ Elsevier (PMID): 28150404 ● Search Scopus @ Elsevier (DOI): 10.1111/jog.13214 (DOI: 10.1111/jog.13214, PubMed: 28150404)
30.	Takashi Kitaichi, Mikio Sugano, Hiroki Arase, Yohei Kawatani, Kanako Kameta, Hirotsugu Kurobe, Eiki Fujimoto, Akemi Ono, Yasunobu Hayabuchi, Hiroshi Fujita, Hitoshi Sogabe and Tetsuya Kitagawa : Long-term results after open mitral commissurotomy for a one-month-old infant with mitral stenosis., The Journal of Medical Investigation : JMI, Vol.64, No.1, 187-191, 2017. (要約) The strategy for an infant with congenital mitral stenosis should be determined by three important factors: left ventricular volume, the degree of the systemic outflow tract obstruction, and the type of mitral valve dysfunction. A successful staged biventricular repair in early infancy for a patient who had congenital mitral stenosis with short chordae, hypoplastic left ventricle and coarctation of the aorta, and the long-term results are described. There were the following important hemodynamic factors that led to the successful biventricular repair in the patient. Total systemic output was barely supplied through the hypoplastic left ventricle after closure of the ductus arteriosus on admission. The neonate underwent repair of coarctation of the aorta alone as the initial stage at 9 days after birth. Also, spontaneous closure of the foramen ovale following repair of coarctation of the aorta accelerated the progressive left ventricular growth. Open mitral commissurotomy with an interatrial fenestration using the modified Brawley's approach was performed for a 40-day-old infant. Good left ventricular growth and good mitral valve function have been observed for 18 years after open mitral commissurotomy. Appropriate early augmentation of left ventricular inflow through the mitral valve might be effective for growth of a hypoplastic left ventricle. J. Med. Invest. 64: 187-191, February, 2017. (徳島大学機関リポジトリ) ● Metadata: 111113 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.64.187 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28373622 ● Summary page in Scopus @ Elsevier: 2-s2.0-85016444426 (徳島大学機関リポジトリ: 111113, DOI: 10.2152/jmi.64.187, PubMed: 28373622, Elsevier: Scopus)
31.	Akemi Ono, Yasunobu Hayabuchi and Shoji Kagami : Coil occlusion of aberrant arteries to pulmonary sequestration in a case with pulmonary atresia with intact ventricular septum: successful treatment of repetitive myocardial ischaemic attacks, Cardiology in the Young, Vol.27, No.1, 193-195, 2017. (要約) In this study, we describe an infant case of pulmonary atresia with intact ventricular septum associated with ventriculo-coronary arterial communication for which a modified Blalock-Taussig shunt operation was performed. He experienced repeated myocardial ischaemic attacks. Further examination revealed pulmonary sequestration in the right lower lobe. He therefore underwent a bidirectional Glenn operation and coil occlusion of the feeding arteries. His myocardial ischaemic attacks subsequently improved. (キーワード) Blalock-Taussig Procedure / Bronchopulmonary Sequestration / Coronary Vessels / Echocardiography / Electrocardiography / Fontan Procedure / Heart Defects, Congenital / Humans / Infant, Newborn / Male / Multidetector Computed Tomography / Myocardial Ischemia / Pulmonary Atresia / Ventricular Septum (出版サイトへのリンク) ● Publication site (DOI): 10.1017/S1047951116001037 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27702416 ● Search Scopus @ Elsevier (PMID): 27702416 ● Search Scopus @ Elsevier (DOI): 10.1017/S1047951116001037 (DOI: 10.1017/S1047951116001037, PubMed: 27702416)
32.	Terada Tomomasa, Kazuhiro Mori, Inoue Miki and Yasunobu Hayabuchi : Mitral annular plane systolic excursion/left ventricular length (MAPSE/L) as a simple index for assessing left ventricular longitudinal function in children., Echocardiography, Vol.33, No.11, 1703-1709, 2016. (要約) Assessment of longitudinal left ventricular (LV) function is important for early detection of cardiac dysfunction. Although mitral annular plane systolic excursion (MAPSE) obtained by M-mode echocardiography offers a simple method for assessing longitudinal LV function, normal values of MAPSE for children change according to body size. To minimize the effects of body size, MAPSE was divided by LV long-axis length (MAPSE/L). MAPSE/L was measured in 210 healthy children from birth to 15 years of age and classified into five subgroups. MAPSE/L was then compared with 10 parameters in 136 children (age, heart rate, mean blood pressure, ejection fraction of the LV (EF), peak atrial flow velocity/peak early diastolic flow velocity of mitral flow, tissue Doppler velocity during systole (s') and early diastole (e'), E/e' ratio, Tei index, and global longitudinal strain (GLS) of the LV by the speckle tracking method). MAPSE/L was significantly lower in the neonate group than in the remaining four groups. MAPSE/L then increased with age to peak at 1-5 years and gradually decreased thereafter. In all cases beyond the neonatal period, MAPSE/L was more than 0.17. Among various parameters, GLS, age, EF, Tei index and s' were significantly associated with MAPSE/L in that order. In univariate analysis, GLS was most significantly associated with MAPSE/L (r=.56). We have established normal reference values for MPSE/L in healthy children. MAPSE/L is expected to offer a simple parameter to evaluate LV longitudinal systolic function during daily routine echocardiography in children. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/echo.13325 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27545275 ● Search Scopus @ Elsevier (PMID): 27545275 ● Search Scopus @ Elsevier (DOI): 10.1111/echo.13325 (DOI: 10.1111/echo.13325, PubMed: 27545275)
33.	Yasunobu Hayabuchi, Ono Akemi, Homma Yukako and Shoji Kagami : Noninvasive assessment of pulmonary arterial capacitance by pulmonary annular motion velocity in children with ventricular septal defect., Cardiovascular Ultrasound, Vol.14, No.1, 38, 2016. (要約) We hypothesized that longitudinal pulmonary arterial deformation during the cardiac cycle reflects pulmonary arterial capacitance. To examine this hypothesis, we assessed whether tissue Doppler-derived pulmonary annular motion could serve as a novel way to evaluate pulmonary arterial capacitance in pediatric patients with ventricular septal defect (VSD). In this prospective study, pulmonary annular velocity was measured in children (age, 6 months-5 years) with a preoperative VSD (VSD group, n = 35) and age-matched healthy children (Control group, n = 23). Pulmonary artery capacitance was calculated by two methods. Systolic pulmonary arterial capacitance (sPAC) was expressed as the stroke volume/pulmonary arterial pulse pressure. Diastolic pulmonary arterial capacitance (dPAC) was determined according to a two-element windkessel model of the pulmonary arterial diastolic pressure profile. Pulmonary annular velocity waveforms comprised systolic bimodal (s1' and s2') and diastolic e' and a' waves in all participants. The peak velocities of s1', s2', and e' were significantly lower in the VSD group than in the Control group. On multiple regression analysis, sPAC was an independent variable affecting the peak velocities of the s1', s2', and e' waves (β = 0.41, 0.62, and 0.35, respectively). The dPAC affected the s1' wave peak velocity (β = 0.34). The time durations of the s1' and e' waves were independently determined by the sPAC (β = 0.49 and 0.27). Pulmonary annular motion velocity evaluated using tissue Doppler is a promising method of assessing pulmonary arterial capacitance in children with VSD. (キーワード) Child, Preschool / Echocardiography, Doppler / Female / Follow-Up Studies / Heart Septal Defects, Ventricular / Heart Ventricles / Humans / Infant / Male / Prospective Studies / Pulmonary Artery / Stroke Volume (徳島大学機関リポジトリ) ● Metadata: 113948 (出版サイトへのリンク) ● Publication site (DOI): 10.1186/s12947-016-0081-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27604100 ● Summary page in Scopus @ Elsevier: 2-s2.0-84985998572 (徳島大学機関リポジトリ: 113948, DOI: 10.1186/s12947-016-0081-4, PubMed: 27604100, Elsevier: Scopus)
34.	Yasunobu Hayabuchi, Ono Akemi, Homma Yukako and Shoji Kagami : Tricuspid L and L' waves, International Journal of Cardiology, Vol.211, 64-65, 2016. (キーワード) Adult / Echocardiography, Doppler / Humans / Male / Tricuspid Valve / Ventricular Dysfunction, Right (徳島大学機関リポジトリ) ● Metadata: 113947 (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijcard.2016.02.160 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26974700 ● Search Scopus @ Elsevier (PMID): 26974700 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2016.02.160 (徳島大学機関リポジトリ: 113947, DOI: 10.1016/j.ijcard.2016.02.160, PubMed: 26974700)
35.	Miki Watanabe, Yasunobu Hayabuchi, Akemi Ono, Takuya Naruto, Hideaki Horikawa, Kiyoshi Masuda, Tomohiro Kohmoto, Ryuji Nakagawa, Hiromichi Ito, Shoji Kagami and Issei Imoto : Detection of 1p36 deletion by clinical exome-first diagnostic approach., Human Genome Variation, Vol.3, 16006, 2016. (要約) Although chromosome 1p36 deletion syndrome is considered clinically recognizable based on characteristic features, the clinical manifestations of patients during infancy are often not consistent with those observed later in life. We report a 4-month-old girl who showed multiple congenital anomalies and developmental delay, but no clinical signs of syndromic disease caused by a terminal deletion in 1p36.32-p36.33 that was first identified by targeted-exome sequencing for molecular diagnosis. (徳島大学機関リポジトリ) ● Metadata: 115133 (出版サイトへのリンク) ● Publication site (DOI): 10.1038/hgv.2016.6 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28428889 ● Summary page in Scopus @ Elsevier: 2-s2.0-85015932495 (徳島大学機関リポジトリ: 115133, DOI: 10.1038/hgv.2016.6, PubMed: 28428889, Elsevier: Scopus)
36.	立花綾香, 加地剛, 七條あつ子, 髙橋洋平, 中山聡一郎, 中川竜二, 前田和寿, 早渕康信, 香美祥二, 苛原稔 : 胎児期から類洞交通を確認できた純型肺動脈閉鎖の一例, 日本周産期・新生児医学会雑誌, Vol.52, No.1, 155-159, 2016年. (徳島大学機関リポジトリ) ● Metadata: 113945 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050566774709068288 (徳島大学機関リポジトリ: 113945, CiNii: 1050566774709068288)
37.	Yasunobu Hayabuchi, Ono Akemi and Shoji Kagami : Pulmonary annular motion velocity assessed using Doppler tissue imaging - Novel echocardiographic evaluation of right ventricular outflow tract function-, Circulation Journal, Vol.80, No.1, 168-176, 2015. (要約) We assessed whether measuring pulmonary annular motion velocity could serve as a novel method of evaluating right ventricular outflow tract (RVOT) performance in pediatric patients with heart disease. Tissue Doppler-derived pulmonary annular motion velocity was determined from the parasternal long-axis view of the RVOT. Pulmonary annular velocity was measured in children (age, 5-10 years) with an atrial septal defect (ASD), pulmonary arterial hypertension (PAH), surgically repaired tetralogy of Fallot (TOF) and healthy children (control). Pulmonary annular velocity waveforms comprised systolic bimodal (s1' and s2') and diastolic e' and a' waves in all groups. The peak velocity of s1' and s2' was significantly higher in the ASD group than in the controls (15.0±2.4 vs. 11.2±2.1 and 6.0±0.9 vs. 4.4±1.2 cm/s; P<0.01 and P<0.001, respectively). The s1' and s2' peak velocities were significantly lower in the PAH group (8.5±1.2 and 3.2±0.4 cm/s; P<0.05 for both), and in the group with TOF (5.3±2.2 and 3.4±1.4 cm/s; P<0.001 and P<0.05, respectively). The peak velocity of e' was significantly decreased in the PAH and TOF, compared with the control group (6.8±1.6 and 8.2±2.9 vs. 11.9±1.9 cm/s; P<0.001 for both). Pulmonary annular motion velocity determined using tissue Doppler imaging is a promising method of assessing RVOT function. (Circ J 2016; 80: 168-176). (キーワード) Child / Child, Preschool / Echocardiography, Doppler / Female / Heart Septal Defects / Humans / Hypertension, Pulmonary / Male / Tetralogy of Fallot (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-15-0695 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26511460 ● Summary page in Scopus @ Elsevier: 2-s2.0-84951767700 (DOI: 10.1253/circj.CJ-15-0695, PubMed: 26511460, Elsevier: Scopus)
38.	本間友佳子, 早渕康信, 阪田美穂, 香美祥二 : 正常肺組織を犠牲にすることを前提としてコイル塞栓術を施行した両側肺全区域びまん性肺動静脈瘻の1 例, 日本小児循環器学会雑誌, Vol.31, No.6, 352-357, 2015年. (出版サイトへのリンク) ● Publication site (DOI): 10.9794/jspccs.31.352 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9794/jspccs.31.352 (DOI: 10.9794/jspccs.31.352)
39.	Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Optical coherence tomography can visualize the pulmonary artery in Williams-Beuren syndrome, European Heart Journal Cardiovascular Imaging, Vol.16, No.9, 967, 2015. (出版サイトへのリンク) ● Publication site (DOI): 10.1093/ehjci/jev109 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25925219 ● Search Scopus @ Elsevier (PMID): 25925219 ● Search Scopus @ Elsevier (DOI): 10.1093/ehjci/jev109 (DOI: 10.1093/ehjci/jev109, PubMed: 25925219)
40.	Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Reply to To PMID 24814570., Echocardiography, Vol.32, No.10, 1603-1604, 2015. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/echo.13029 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 26444453 ● Search Scopus @ Elsevier (PMID): 26444453 ● Search Scopus @ Elsevier (DOI): 10.1111/echo.13029 (DOI: 10.1111/echo.13029, PubMed: 26444453)
41.	Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Aortic forward flow in aortic atresia via ventriculo-coronary arterial connections., European Heart Journal Cardiovascular Imaging, Vol.16, No.8, 847, 2015. (出版サイトへのリンク) ● Publication site (DOI): 10.1093/ehjci/jev077 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25851321 ● Summary page in Scopus @ Elsevier: 2-s2.0-84942093190 (DOI: 10.1093/ehjci/jev077, PubMed: 25851321, Elsevier: Scopus)
42.	Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Right ventricular myocardial deformation patterns in children with congenital heart disease associated with right ventricular pressure overload., European Heart Journal Cardiovascular Imaging, Vol.16, No.8, 890-899, 2015. (要約) Longitudinal wall motion of the right ventricle (RV) has been thoroughly studied in patients with RV dysfunction. However, circumferential strain of the RV free wall has yet to be investigated. Therefore, this study was conducted to assess the utility of RV free wall circumferential strain. Strain profile curves were obtained using speckle tracking echocardiography from the subcostal left ventricular (LV) short-axis view in 30 normal children (normal group) and 25 patients with RV pressure overload (RVO group). The time-strain curves of three individual segmental (anterior, lateral, and inferior segments) and global circumferential deformations were evaluated. RV ejection fraction (RVEF), RV systolic pressure (RVSP), and RV fractional area change obtained in the four-chamber view and LV short-axis view [RVFAC (4CH) and RVFAC (SAX), respectively] were measured, and their relationships with RV free wall deformation were assessed. In the normal group, circumferential strain was significantly lower in the anterior segment than in the other segments. The inferior segment had a significantly larger strain than the other segments in the RVO group. Circumferential strain was predominant over longitudinal RV free wall strain in the RVO group (-18.4 ± 3.9 vs. -14.2 ± 3.8%, respectively; P < 0.005), whereas no significant difference between them was observed in the normal group (-23.0 ± 3.9 vs. -22.4 ± 4.7%, respectively). Global circumferential strain had a significantly higher correlation with RVFAC (4CH), RVFAC (SAX), RVEF, and RVSP than global longitudinal strain (P < 0.05 for all). RV free wall circumferential strain provides better information about RV function than longitudinal strain in children with RVO. (出版サイトへのリンク) ● Publication site (DOI): 10.1093/ehjci/jev011 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25711349 ● Summary page in Scopus @ Elsevier: 2-s2.0-84942097396 (DOI: 10.1093/ehjci/jev011, PubMed: 25711349, Elsevier: Scopus)
43.	Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Bronchogenic cyst compressing the pulmonary artery and the left atrium., European Heart Journal Cardiovascular Imaging, Vol.16, No.7, 746, 2015. (出版サイトへのリンク) ● Publication site (DOI): 10.1093/ehjci/jev059 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 25750196 ● Summary page in Scopus @ Elsevier: 2-s2.0-84942108966 (DOI: 10.1093/ehjci/jev059, PubMed: 25750196, Elsevier: Scopus)
44.	Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Assessment of the Helical Ventricular Myocardial Band Using Standard Echocardiography, Echocardiography, Vol.32, No.2, 310-318, 2015. (要約) The purpose of this study was to assess the feasibility of morphological and functional evaluation of the helical ventricular myocardial band using standard echocardiographic images. Echocardiographic data were obtained from 132 normal children. We attempted to identify the echogenic bright line serving as the boundary between the ascending and descending segments in the ventricular septum, and between the left and ascending segments in the left ventricular inferior wall in the helical myocardial band model proposed by Torrent-Guasp. Myocardial deformations on both sides of the bright line were compared using speckle tracking echocardiography. The bright line separating the ascending from descending segment was visible in the mid-ventricular septum in the four-chamber view in all subjects. This echogenic boundary was observed obliquely in the parasternal short-axis view in 116 subjects (87.9%). There was no significant difference in peak longitudinal or circumferential strain between the ascending and descending segments. However, the time from the QRS onset to peak circumferential strain was significantly lower in the descending than ascending segment (394.5 ± 37.0 vs. 432.7 ± 33.1 ms, P < 0.0001), whereas there was no significant difference in the time to peak longitudinal strain (394.4 ± 26.4 vs. 393.2 ± 24.1 ms). The bright line between the left and ascending segment was detected in the short-axis view from the subcostal region in 86 subjects (65.2%). The time to peak circumferential strain was significantly lower in the left than ascending segment (380.1 ± 32.0 vs. 435.7 ± 37.9 ms, P < 0.0001). There is a helical ventricular myocardial band that can be observed in standard echocardiographic images. (キーワード) Child / Child, Preschool / Feasibility Studies / Female / Heart Ventricles / Humans / Infant / Male / Myocardial Contraction / Prospective Studies / Reference Values / Ventricular Function (出版サイトへのリンク) ● Publication site (DOI): 10.1111/echo.12624 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24814570 ● Summary page in Scopus @ Elsevier: 2-s2.0-84922643382 (DOI: 10.1111/echo.12624, PubMed: 24814570, Elsevier: Scopus)
45.	Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Fibromyxoid excrescence of the aortic valve that manifested after catheterisation and required resection., Cardiology in the Young, Vol.25, No.2, 362-364, 2015. (要約) A 2-year-old boy developed fibromyxoid excrescence of the aortic valve 2 years after balloon dilatation for simple coarctation. Transthoracic echocardiography showed a mobile mass on the non-coronary cusp of the aortic valve. Definitive diagnosis was achieved after operative resection. This pathology was attributed to injury during catheter manipulation. Catheterised patients should be followed up carefully to avoid missing morphological changes. (キーワード) Angioplasty, Balloon / Aortic Coarctation / Aortic Valve / Cardiac Catheterization / Child, Preschool / Heart Defects, Congenital / Heart Valve Diseases / Humans / Male / Postoperative Complications (出版サイトへのリンク) ● Publication site (DOI): 10.1017/S1047951114000092 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24495334 ● Summary page in Scopus @ Elsevier: 2-s2.0-84927689920 (DOI: 10.1017/S1047951114000092, PubMed: 24495334, Elsevier: Scopus)
46.	Masashi Suzue, Kazuhiro Mori, MIki Inoue, Yasunobu Hayabuchi, Ryuji Nakagawa and Shoji Kagami : Developmental changes in the left ventricular diastolic wall strain on M-mode echocardiography, Journal of Echocardiography, Vol.12, No.3, 98-105, 2014. (要約) The diastolic wall strain (DWS) of the left ventricle has been proposed as an indicator of left ventricular (LV) wall stiffness. The DWS is calculated as follows using M-mode echocardiography:[Formula: see text]Although this index is simple and clinically useful, normal values for children, including neonates, have not been reported. The DWS was measured in 235 healthy people, ranging from neonates to adults. They were classified into 8 subgroups according to their age. The DWS was compared with conventional echocardiographic parameters for left ventricle function, including shortening fraction of the left ventricle, the Tei index, E/A of mitral flow, mitral annular tissue Doppler velocity during systole (s') and during early diastole (e'), and the E/e' ratio. The DWS in the just after birth group was 0.28 ± 0.11, which was significantly lower than that of the remaining groups (p < 0.05), except for the neonate group at 5-10 days after birth. The DWS was highest in the 1-9 years of age group, and then gradually decreased with age. Stepwise regression of various echocardiographic parameters showed that e' was the most relevant parameter for the DWS (β = 0.64). Normal values for the DWS of the left ventricle change with age. The data reported in this study can be used as normal values for the DWS of the left ventricle determined by M-mode echocardiography. (キーワード) Adolescent / Adult / Child / Child, Preschool / Diastole / Echocardiography / Echocardiography, Doppler / 女性 (female) / Heart Ventricles / Humans / 小児 (infant) / Infant, Newborn / Systole / Ventricular Dysfunction, Left / Ventricular Function, Left / Young Adult (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-014-0222-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 27276893 ● Summary page in Scopus @ Elsevier: 2-s2.0-84907781830 (DOI: 10.1007/s12574-014-0222-4, PubMed: 27276893, Elsevier: Scopus)
47.	P Fan, Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Continuing medical education activity in echocardiography., Echocardiography, Vol.31, No.7, 814, 2014. (出版サイトへのリンク) ● Publication site (DOI): 10.1111/echo.12728 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1111/echo.12728 (DOI: 10.1111/echo.12728)
48.	Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Assessment of Two-Component Ventricular Septum: Functional Differences in Systolic Deformation and Rotation Assessed by Speckle Tracking Imaging., Echocardiography, Vol.31, No.7, 815-823, 2014. (要約) The purpose of this study was to elucidate functional differences in the right and left components of the ventricular septum (Rt and Lt, respectively). Strain, strain rate, rotation, and rotation rate profile curves of Rt and Lt were obtained using speckle tracking echocardiography in 38 normal children and adolescents. The echogenic bright line serving as the boundary separating Rt from Lt was consistently visible in the middle of the ventricular septum. There was no significant difference in peak strain or peak strain rate during systole between Rt and Lt. However, the time interval from the onset of QRS-wave to peak strain and peak strain rate were significantly lower in Lt than in Rt in terms of radial and circumferential deformation (P < 0.005, all), whereas there was no significant difference in longitudinal deformation in the time to peak strain or peak strain rate between Rt and Lt. Lt showed counterclockwise rotation, whereas Rt showed clockwise rotation (10.4 ± 2.9° vs. -10.2 ± 2.6°, P < 0.0001). Time to peak rotation was significantly lower in Lt than in Rt (201.7 ± 32.7 msec vs. 370.4 ± 31.2 msec, P < 0.0001). Morphologically and functionally the ventricular septum is a two-component structure. Evaluation of deformation and rotation of the 2 components would help in evaluating septal performance. (キーワード) Adolescent / Child / Child, Preschool / Echocardiography, Doppler / Female / Humans / Male / Prospective Studies / Reproducibility of Results / Ventricular Dysfunction / Ventricular Septum (出版サイトへのリンク) ● Publication site (DOI): 10.1111/echo.12484 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 24341366 ● Search Scopus @ Elsevier (PMID): 24341366 ● Search Scopus @ Elsevier (DOI): 10.1111/echo.12484 (DOI: 10.1111/echo.12484, PubMed: 24341366)
49.	早渕康信, 阪田美穂, 小野朱美, 香美祥二 : 光干渉断層像(Optical Coherence Tomography)で肺血管病変を観察した特発性肺動脈性肺高血圧症, 日本小児循環器学会雑誌, Vol.30, No.3, 365-370, 2014年. (出版サイトへのリンク) ● Publication site (DOI): 10.9794/jspccs.30.365 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9794/jspccs.30.365 (DOI: 10.9794/jspccs.30.365)
50.	Akemi Ono, Yasunobu Hayabuchi, Miho Sakata, Yuko Ichihara, Shoji Kagami and Kazuhiro Mori : Right ventricular thrombosis in two patients with pulmonary atresia with intact ventricular septum, Journal of Echocardiography, Vol.12, No.2, 62-64, 2014. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-014-0210-8 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-014-0210-8 (DOI: 10.1007/s12574-014-0210-8)
51.	Yasunobu Hayabuchi, Miho Sakata, Miki Inoue, Kazuhiro Mori and Shoji Kagami : Echocardiographic assessment of anomalous origin of the left coronary artery from the pulmonary artery, Journal of Echocardiography, Vol.12, No.2, 60-61, 2014. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-014-0207-3 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-014-0207-3 (DOI: 10.1007/s12574-014-0207-3)
52.	早渕康信 : 学校生活で悩む不整脈症例 -この症例をどう扱うか?-, 若年者心疾患・生活習慣病対策協議会誌, Vol.41, No.1, 41-45, 2013年.
53.	Yasunobu Hayabuchi, Miho Sakata, Tatsuya Ohnishi, Inoue Miki and Shoji Kagami : Ratio of early diastolic tricuspid inflow to tricuspid lateral annulus velocity reflects pulmonary regurgitation severity but not right ventricular diastolic function in children with reparied terralogy of Fallot, Pediatric Cardiology, Vol.34, No.5, 1112-1117, 2013. (要約) The current study assessed relationships between the ratio of early diastolic tricuspid inflow to tricuspid lateral annular velocity (tricuspid E/e') and right ventricular (RV) function in children after tetralogy of Fallot (TOF) repair. The RV function of 25 asymptomatic children with surgically repaired TOF (age 3.3 ± 2.0 years) was assessed by echocardiography and cardiac catheterization. Right ventricular end-diastolic pressure and volume (RVEDP and RVEDV), systolic pressure, and ejection fraction, as well as mean pulmonary arterial pressure, mean right atrial pressure (RAP), and the severity of both pulmonary regurgitation (PR) and tricuspid regurgitation (TR) were assessed in terms of the contribution to tricuspid E/e'. Univariate analysis discovered a relationship between tricuspid E/e' and RVEDV (R(2) = 0172), pressure half-time of PR (PR-PHT) (R(2) = 0.173), and TR grade (R(2) = 0.145) (p < 0.01 for each). After multivariate adjustment, PR-PHT was significantly associated with tricuspid E/e' (β = 0.210; p < 0.001). Tricuspid E/e' was not significantly associated with RVEDP or RAP. In conclusion, tricuspid E/e' does not indicate RV diastolic function but reflects the severity of PR in asymptomatic children after TOF repair. (キーワード) Blood Flow Velocity / Cardiac Catheterization / Child / Child, Preschool / Diastole / Echocardiography / Female / Heart Function Tests / Humans / Infant / Male / Pulmonary Valve Insufficiency / Severity of Illness Index / Tetralogy of Fallot / Tricuspid Valve (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00246-012-0612-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23247587 ● Summary page in Scopus @ Elsevier: 2-s2.0-84878011389 (DOI: 10.1007/s00246-012-0612-1, PubMed: 23247587, Elsevier: Scopus)
54.	Yasunobu Hayabuchi, Inoue Miki, Miho Sakata, Tatsuya Ohnishi and Shoji Kagami : Subclavian and pulmonary artery steal phenomenon in a patient with isolated left subclavian artery and right aortic arch., Journal of Clinical Ultrasound, Vol.41, No.4, 265-268, 2013. (要約) We describe a patient with an isolated left subclavian artery associated with right aortic arch, patent ductus arteriosus, and ventricular septal defect. As the isolated left subclavian artery is supplied by the left vertebral artery in which blood flows in the retrograde direction, this anomaly is usually responsible for a congenital subclavian steal phenomenon. Atrophy of the left cerebral hemisphere and inverted left vertebral arterial flow were clearly depicted by echoencephalography in this patient, whose subclavian artery was connected to the main pulmonary artery by a patent ductus arteriosus. (キーワード) Abnormalities, Multiple / Aorta, Thoracic / Ductus Arteriosus, Patent / Female / Heart Septal Defects, Ventricular / Humans / Infant / Subclavian Artery / Subclavian Steal Syndrome / Vascular Malformations (出版サイトへのリンク) ● Publication site (DOI): 10.1002/jcu.21874 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22238123 ● Summary page in Scopus @ Elsevier: 2-s2.0-84876413072 (DOI: 10.1002/jcu.21874, PubMed: 22238123, Elsevier: Scopus)
55.	Hirotsugu Kurobe, Takashi Tominaga, Mikio Sugano, Yasunobu Hayabuchi, Yoshiyasu Egawa, Yousuke Takahama and Tetsuya Kitagawa : Complete but not partial thymectomy in early infancy reduces T-cell-mediated immune response: three-year tracing study after pediatric cardiac surgery., Journal of Thoracic and Cardiovascular Surgery, Vol.145, No.3, 656-662, 2013. (要約) The results revealed that complete thymectomy in early infancy reduces the number of circulating T cells and T-cell-mediated immune responses for at least 3 years, suggesting that the thymus should be at least partially preserved during surgery in early infancy to maintain protective immunity. (キーワード) Female / Heart Defects, Congenital / Humans / Immunity, Cellular / Immunoglobulin G / Infant / Infant, Newborn / Male / Measles-Mumps-Rubella Vaccine / Severity of Illness Index / T-Lymphocytes / Thymectomy / Thymus Gland (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.jtcvs.2012.12.015 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 23312343 ● Search Scopus @ Elsevier (PMID): 23312343 ● Search Scopus @ Elsevier (DOI): 10.1016/j.jtcvs.2012.12.015 (DOI: 10.1016/j.jtcvs.2012.12.015, PubMed: 23312343)
56.	Miho Sakata, Yasunobu Hayabuchi, Inoue Miki, Tatsuya Ohnishi and Shoji Kagami : Left atrial volume change throughout the cardiac cycle in children with congenital heart disease associated with increased pulmonary blood flow: evaluation using a novel left atrium-tracking method., Pediatric Cardiology, Vol.34, No.1, 105-111, 2013. (要約) There is a paucity of data regarding the significance of left atrial (LA) volume and its changes throughout the cardiac cycle in pediatric patients with heart disease. The recently developed LA volume-tracking (LAVT) method can automatically construct the LA volume curve. The study group consisted of 48 pediatric patients with ventricular septal defect (n = 34) or patent ductus arteriosus (n = 14) and age-matched healthy controls. Maximum and minimum LA volumes (LAVmax and LAVmin, respectively) were measured. The total LA emptying volume (LAVtotal) was defined as LAVmax--LAVmin. Volume parameters were standardized by dividing by body surface area (BSA). The total LA emptying fraction (%LAVtotal) was defined as the ratio of LAVtotal to LAVmax. In the patient group, there was a positive correlation between the ratio of pulmonary to systemic blood flow (Qp/Qs) and LAVmax/BSA, LAVmin/BSA, and LAVtotal/BSA (r = 0.42, 0.44, and 0.34, respectively). LAVmin/BSA was positively correlated with the ratio of early mitral inflow velocity to early mitral annular diastolic tissue Doppler velocity (E/E') (r = 0.32). The %LAVtotal had a negative correlation with left-ventricular (LV) end-diastolic pressure (r = -0.32). There were significant correlations between serum B-type natriuretic peptide level and LAVmax/BSA, LAVmin/BSA, and %LAVtotal (r = 0.38, 0.49, and -0.35, respectively). The LAVT method is useful in the evaluation of LV diastolic function in pediatric patients with chronic LV volume overload. (キーワード) Atrial Function, Left / Cardiac Catheterization / Child / Child, Preschool / Echocardiography, Doppler / Female / Heart Atria / Heart Defects, Congenital / Humans / Male / Observer Variation / Pulmonary Circulation (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00246-012-0395-4 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22660522 ● Summary page in Scopus @ Elsevier: 2-s2.0-84872615204 (DOI: 10.1007/s00246-012-0395-4, PubMed: 22660522, Elsevier: Scopus)
57.	M Suzue, Kazuhiro Mori and Yasunobu Hayabuchi : Congenital ductus arteriosus aneurysm., Journal of Echocardiography, Vol.10, No.3, 112-114, 2012. (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-012-0137-x (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1573668925934058368 ● Summary page in Scopus @ Elsevier: 2-s2.0-84866525681 (DOI: 10.1007/s12574-012-0137-x, CiNii: 1573668925934058368, Elsevier: Scopus)
58.	N Watanabe, Yasunobu Hayabuchi, Ryuji Nakagawa, T Saijo and Shoji Kagami : Multidetector-row computed tomography evaluation of bilateral bronchial narrowing associated with increased pulmonary blood flow in children with congenital heart disease., Congenital Heart Disease, Vol.7, No.5, 410-416, 2012. (要約) Quantitative assessment of bilateral bronchial narrowing in children with congenital heart disease (CHD) with a left-to-right shunt has not yet been reported. In the present study, main bronchial size was evaluated bilaterally in normal subjects using multidetector-row computed tomography (MDCT), and the feasibility for diagnosis of bronchial narrowing in children with CHD associated with increased pulmonary blood flow was investigated. The short-axis diameter, long-axis diameter, and the cross-sectional area of the bilateral bronchi were measured immediately proximal to the origin of the superior lobar branch in 86 children aged 1-52 months. Subjects were divided into three groups as follows: group 1 (normal subjects; n = 52), group 2 (asymptomatic left-to-right shunt group; n = 25), and group 3 (symptomatic left-to-right shunt group with respiratory insufficiency; n = 9). Age, height, weight, and body surface area were significantly correlated with short- and long-axis bronchial diameters, and bronchial cross-sectional area in group 1. In group 2, the left bronchial cross-sectional area was significantly lower than group 1 (P < .001), whereas the right bronchial area was not significantly different. In group 3, the right bronchial area was significantly lower than that in groups 1 and 2 (P < .05). Although the left bronchial area in group 3 was significantly lower than in group 1 (P < .001), it was not significantly different from that in group 2. Our study suggests that MDCT can be used to quantify bilateral bronchial narrowing. Left main bronchial obstruction develops during the early stage of heart failure, followed by the development of right bronchial narrowing. (キーワード) Bronchi / Bronchoconstriction / Bronchography / Case-Control Studies / Child, Preschool / Feasibility Studies / Female / Heart Defects, Congenital / Humans / Infant / Infant, Newborn / Male / Multidetector Computed Tomography / Predictive Value of Tests / Pulmonary Artery / Pulmonary Circulation / Regional Blood Flow / Respiratory Insufficiency (徳島大学機関リポジトリ) ● Metadata: 106307 (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1747-0803.2012.00653.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 22494607 ● Search Scopus @ Elsevier (PMID): 22494607 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1747-0803.2012.00653.x (徳島大学機関リポジトリ: 106307, DOI: 10.1111/j.1747-0803.2012.00653.x, PubMed: 22494607)
59.	T Oonishi, Yasunobu Hayabuchi, Miho Sakata, Kenji Mori and Shoji Kagami : Stent placement in the ductus venosus of a neonate with total anomalous pulmonary venous return., Journal of Echocardiography, Vol.10, No.1, 27-29, 2012. (キーワード) Total anomalous pulmonary venous return / Ductus venosus / Stent implantation / Neointimal proliferation / Pulmonary venous obstruction / Transthoracic echocardiography (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-011-0102-0 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1573950400547028864 ● Summary page in Scopus @ Elsevier: 2-s2.0-84857911299 (DOI: 10.1007/s12574-011-0102-0, CiNii: 1573950400547028864, Elsevier: Scopus)
60.	早渕康信, 阪田美穂, 香美祥二 : 肝機能障害なくボセンタンが奏功した胆道閉鎖を合併した多脾症候群・両方向性グレン術後症例, モダンフィジシャン, Vol.48, 48-51, 2012年.
61.	Yasunobu Hayabuchi, Miki Inoue, Noriko Watanabe, Miho Sakata, Tatsuya Ohnishi and Shoji Kagami : Consideration of the Pathological Features of Pediatric Congenital Heart Diseases Which Are Ideally Suitable for Diagnosing With Multidetector-row CT., Cardiology Research, Vol.2, No.4, 150-159, 2011. (要約) A lots of articles published regarding the usefulness of multidetector-row computed tomography (MDCT) in children with congenital heart disease (CHD) mostly describe that it can be an alternative to the invasive catheterization and angiography. The unique diagnostic features of this imaging modality have been largely ignored or disregarded. We described the pathological conditions that cannot be diagnosed by conventional angiography with cardiac catheterization but can be accurately diagnosed by MDCT. We retrospectively reviewed non-ECG-gated MDCT images acquired from 452 children and young adults with CHD between 2005 and 2010 in our institute. In this article, we focused on the diagnostic advantages of MDCT, and indicated five pathological conditions. (1) When Blalock-Taussig shunt total occlusion prevents catheter insertion into the artificial vessel and angiography is ruled out, the peripheral pulmonary artery during the peripheral pulmonary artery can be imaged and diagnosed using MDCT based on blood flow supplied from many small collateral vessels originating from the aorta. (2) The location and protrusion of the device in the vessel after coil embolization to treat patent ductus arteriosus can be accurately visualized by virtual endoscopy using MDCT. (3) Calcification of patches, synthetic blood vessels, and other prostheses that is indistinct on conventional angiograms is clear on MDCT. (4) Simultaneous MDCT observations of the anatomical relationships between arterial and venous systems on the same image can clarify the detail diagnosis for surgical treatment. (5) Compression of the airways by the great vessels and pulmonary segmental emphysematous change can be diagnosed by MDCT. Among patients with CHD, MDCT is useful not only as a non-invasive alternative to conventional angiography, but also as a tool for specific morphological diagnoses. In the future, it will be necessary to accumulate experience in the recognition of cardiovascular conditions under which MDCT is necessary and to perform as the appropriate examination. (出版サイトへのリンク) ● Publication site (DOI): 10.4021/cr61w (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 28352384 ● Search Scopus @ Elsevier (PMID): 28352384 ● Search Scopus @ Elsevier (DOI): 10.4021/cr61w (DOI: 10.4021/cr61w, PubMed: 28352384)
62.	Yasunobu Hayabuchi, Miho Sakata, Tatsuya Ohnishi and Shoji Kagami : A novel bilayer approach to ventricular septal deformation analysis by speckle tracking imaging in children with right ventricular overload, Journal of the American Society of Echocardiography, Vol.24, No.11, 1205-1212, 2011. (要約) The aim of this study was to evaluate functional differences between the left and right sides of the ventricular septum in children with right ventricular overload. Radial, longitudinal, and circumferential strain on both sides of the ventricular septum were compared using speckle-tracking echocardiography in patients with preoperative atrial septal defects (n = 22), postoperative tetralogy of Fallot (n = 23) and age-matched normal controls (n = 44). The duration between peak strain of the left and right ventricular septum (TLt-Rt) was also evaluated. Radial and circumferential strain in the control group were significantly higher on the left than the right ventricular septum (41.3 ± 12.8% vs 22.6 ± 6.8% and -28.0 ± 5.4% vs -22.5 ± 4.8%, respectively; P < .0001 for both), whereas longitudinal strain did not significantly differ (-22.0 ± 4.9% and -20.7 ± 5.2%, respectively). TLt-Rt was 52.9 ± 35.6, 33.4 ± 29.0, and 38.7 ± 31.0 msec for radial, longitudinal, and circumferential strain, respectively. Longitudinal and circumferential strain on both sides were significantly increased in patients with atrial septal defects compared with controls (P < .05), although radial strain was similar on both sides. Radial strain on the right side was significantly increased in patients with tetralogy of Fallot compared with controls (P < .05), whereas that on the left side was significantly reduced (P < .001). Longitudinal strain on both sides was significantly decreased (P < .01 and P < .001 for the left and right sides, respectively). In addition, TLt-Rt in patients with tetralogy of Fallot was significantly increased with radial and circumferential deformation (P < .05 for both). Deformation of both sides of the ventricular septum functionally differed. Bilayer analysis of the ventricular septum can help in the evaluation of right ventricular performance under volume and pressure overload. (キーワード) Adolescent / Child / Child, Preschool / Echocardiography, Doppler / Female / Heart Catheterization / Heart Septal Defects, Atrial / Heart Septum / Humans / Image Interpretation, Computer-Assisted / Male / Tetralogy of Fallot / Ventricular Dysfunction, Right (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.echo.2011.06.016 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21820866 ● Search Scopus @ Elsevier (PMID): 21820866 ● Search Scopus @ Elsevier (DOI): 10.1016/j.echo.2011.06.016 (DOI: 10.1016/j.echo.2011.06.016, PubMed: 21820866)
63.	Yasunobu Hayabuchi, Miki Inoue, Miho Sakata and Shoji Kagami : Multidetector-row computed tomography visualized peripheral pulmonary artery patency in a patient with occluded modified Blalock-Taussig shunt, International Journal of Cardiology, Vol.150, No.2, e57-e58, 2011. (要約) Multidetector-row computed tomography visualized peripheral pulmonary artery patency in a 19-year-old female with a single ventricle and an occluded Blalock-Taussig shunt whereas conventional invasive angiography did not. (キーワード) Blalock-Taussig Procedure / Equipment Failure / Female / Humans / Pulmonary Artery / Tomography, X-Ray Computed / Vascular Patency / Young Adult (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijcard.2009.10.010 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19897263 ● Search Scopus @ Elsevier (PMID): 19897263 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2009.10.010 (DOI: 10.1016/j.ijcard.2009.10.010, PubMed: 19897263)
64.	Yasunobu Hayabuchi, Miki Inoue, Noriko Watanabe, Miho Sakata, Tatsuya Ohnishi and Shoji Kagami : Serum concentration of Heart-type fatty acid-binding protein in children and adolescents with congenital heart disease, Circulation Journal, Vol.75, No.8, 1992-1997, 2011. (要約) Serum heart-type fatty acid-binding protein (H-FABP) is widely applied as a marker of cardiac myocyte injury. Recently, it has been reported that levels of H-FABP are elevated in adult patients with chronic heart failure and thus provide useful prognostic information. The aim of the present study was to examine the relationships between serum H-FABP levels and pathophysiological characteristics in children and adolescents with congenital heart disease (CHD). Serum H-FABP levels were preoperatively and postoperatively measured in 238 consecutive patients with CHD aged 1-31 years. The relationships between H-FABP levels and severity of heart failure, circulatory status and laboratory data were cross-sectionally analyzed. Multivariate regression analysis indicated that serum H-FABP levels are independently affected by age, New York Heart Association functional class, creatine kinase MB, creatinine and arterial oxygen saturation (standard regression coefficients, -0.378, 0.237, 0.422, 0.615, and -0.210, respectively). Neither left ventricular ejection fraction nor B-type natriuretic peptide correlated with H-FABP levels. H-FABP could serve as a new monitoring tool to provide information that will guide the optimal therapy and management of CHD patients. (キーワード) Adolescent / Adult / Biological Markers / Child / Child, Preschool / Creatine Kinase, MB Form / Creatinine / Cross-Sectional Studies / Fatty Acid-Binding Proteins / Heart Defects, Congenital / Humans / Infant / Male / Natriuretic Peptide, Brain / Prospective Studies / Stroke Volume (出版サイトへのリンク) ● Publication site (DOI): 10.1253/circj.CJ-10-1256 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21617322 ● Search Scopus @ Elsevier (PMID): 21617322 ● Search Scopus @ Elsevier (DOI): 10.1253/circj.CJ-10-1256 (DOI: 10.1253/circj.CJ-10-1256, PubMed: 21617322)
65.	Yasunobu Hayabuchi, Miki Inoue, Noriko Watanabe, Miho Sakata, Manal Helmy Mohamed Nabo and Shoji Kagami : Minimum-intensity projection of multidetector-row computed tomography for assessment of pulmonary hypertension in children with congenital heart disease, International Journal of Cardiology, Vol.149, No.2, 192-198, 2011. (要約) The present study aimed to assess the feasibility of minimum-intensity projection (minIP) images for the evaluation of pulmonary hypertension (PH) in children with congenital heart disease (CHD). A total of 70 consecutive patients (mean age, 4.6 ± 4.4 years; range, 6 months-16 years) underwent multidetector-row computed tomography (MDCT) angiography of the thorax prior to cardiac catheterization and lung perfusion scintigraphy. Contiguous axial, coronal and sagittal minIP images of 5-mm thickness were reconstructed from the contrast-enhanced CT datasets. Two reviewers evaluated the images in consensus and qualitatively graded lung parenchyma attenuation as homogeneous (Class I), slightly heterogeneous lung attenuation that does not conform to the anatomic boundaries of the secondary pulmonary lobule (Class II), and mosaic pattern (Class III). MinIP attenuation grading results were then compared with those of perfusion scintigraphy. Furthermore, the relationships between the results of these modalities and mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) were evaluated. In 51 (73%) patients, concordant findings were observed between the modalities, although minIP showed a higher grade for heterogeneous images than did scintigraphy. mPAP and PVR showed significant difference among the minIP attenuation classes (p<0.0001 for both). High-grade heterogeneous minIP images were associated with high mPAP, high PVR, presence of major aortopulmonary collateral artery, and chromosomal abnormality. MinIP is a promising technique for depicting lung perfusion and can be used as superior alternative to scintigraphy in the evaluation of PH. (キーワード) Adolescent / Child / Child, Preschool / Female / Heart Defects, Congenital / Humans / Hypertension, Pulmonary / Infant / Male / Radiation Dosage / Tomography, X-Ray Computed (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijcard.2010.01.008 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20144487 ● Search Scopus @ Elsevier (PMID): 20144487 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2010.01.008 (DOI: 10.1016/j.ijcard.2010.01.008, PubMed: 20144487)
66.	Helmy Manal Mohamed Nabo, Yasunobu Hayabuchi, Miki Inoue, Noriko Watanabe, Miho Sakata, Tatsuya Ohnishi and Shoji Kagami : Pulmonary emphysematous changes in patients with congenital heart disease associated with increased pulmonary blood flow, --- Evaluatio using multidetector-row computed tomography ---, Heart, Lung & Circulation, Vol.20, No.9, 587-592, 2011. (要約) The present study aimed to evaluate the prevalence and the location of segmental emphysematous change in congenital heart disease (CHD) patients with increased pulmonary blood flow using multidetector-row computed tomography (MDCT). A total of 129 consecutive patients (mean age, 5.8±5.4 years; range, 1 month to 24 years) underwent MDCT angiography of the thorax. The frequency of emphysematous change was evaluated in patients with ventricular septal defect (VSD, n=61), atrial septal defect (ASD, n=27), patent ductus arteriosus (PDA, n=36) and complete atriventriclar septal defect (CAVSD, n=5). In 59 patients who underwent cardiac catheterisation, the relationships between the emphysematous change and both pulmonary to systemic blood flow ratio (Qp/Qs) and mean pulmonary arterial pressure (mPAP) were evaluated. The emphysematous change was detected in 57 patients (44.2%) out of 129 patients. The frequency of segmental emphysematous change in left side was higher than in right side (14.8% vs. 6.5%). Both Qp/Qs and mPAP affected the presence of emphysema. MDCT can provide accurate detection of segmental emphysema in patients with CHD. Emphysematous change is not uncommon pathological lesion in children and adolescents with CHD. (キーワード) Adolescent / Adult / Angiography / Blood Flow Velocity / Child / Child, Preschool / Female / Heart Defects, Congenital / Humans / Infant / Male / Multidetector Computed Tomography / Pulmonary Emphysema (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.hlc.2011.04.038 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21621459 ● Search Scopus @ Elsevier (PMID): 21621459 ● Search Scopus @ Elsevier (DOI): 10.1016/j.hlc.2011.04.038 (DOI: 10.1016/j.hlc.2011.04.038, PubMed: 21621459)
67.	Yasunobu Hayabuchi, Yutaka Nakaya, Kazuaki Mawatari, Miki Inoue, Miho Sakata and Shoji Kagami : Cell membrane stretch activates intermediate-conductance Ca2+-activated K+ channels in arterial smooth muscle cells, Heart and Vessels, Vol.26, No.1, 91-100, 2011. (要約) The aim of this study is to determine the signal transduction of membrane stretch on intermediate-conductance Ca(2+)-activated K(+) (IKca) channels in rat aorta smooth muscle cells using the patch-clamp technique. To stretch the cell membrane, both suction to the rear end of patch pipette and hypotonic shock were used. In cell-attached and inside-out patch configurations, the open probability of IKca channels increased when 20- to 45-mmHg suction was applied. Hyposmotic swelling efficiently increased IKca channel current. When the Ca(2+)-free solution was superfused, the activation of IKca current by the hyposmotic swelling was reduced. Furthermore, gadolinium (Gd(3+)) attenuated the activation of IKca channels induced by hyposmotic swelling, whereas nicardipine did not. In the experiments with Ca(2+)-free bath solution, pretreatment with GF109203X, a protein kinase C (PKC) inhibitor, completely abolished the stretch-induced activation of IKca currents. The stretch-induced activation of IKca channels was strongly inhibited by cytochalasin D, indicating a role for the F-actin in modulation of IKca channels by changes in cell stretching. These data suggest that cell membrane stretch activates IKca channels. In addition, the activation is associated with extracellular Ca(2+) influx through stretch-activated nonselective cation channels, and is also modulated by the F-actin cytoskeleton and the activation of PKC. (キーワード) Actins / Animals / Aorta / Cell Line / Cell Size / Enzyme Activation / Hypotonic Solutions / Intermediate-Conductance Calcium-Activated Potassium Channels / Ion Channel Gating / Mechanotransduction, Cellular / Membrane Potentials / Muscle, Smooth, Vascular / Myocytes, Smooth Muscle / Osmotic Pressure / Patch-Clamp Techniques / Potassium Channel Blockers / Protein Kinase C / Protein Kinase Inhibitors / Rats / Time Factors (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00380-010-0025-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 21063882 ● Search Scopus @ Elsevier (PMID): 21063882 ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-010-0025-0 (DOI: 10.1007/s00380-010-0025-0, PubMed: 21063882)
68.	Miki Inoue, Yasunobu Hayabuchi and Shoji Kagami : Development of systemic-to-pulmonary collateral arteries in a patients with hypoplastic left heart syndrome after bilateral pulmonary artery banding, Cardiology in the Young, Vol.20, No.4, 465-467, 2010. (要約) We describe systemic-to-pulmonary collateral arteries that developed after bilateral pulmonary artery banding in a patient with hypoplastic left cardiac syndrome. The growth of collateral arteries should be evaluated carefully because bilateral pulmonary artery banding under prostaglandin E1 administration is considered an initial palliative option. (キーワード) Collateral Circulation / Coronary Circulation / Female / Humans / Hypoplastic Left Heart Syndrome / Infant, Newborn / Pulmonary Artery (出版サイトへのリンク) ● Publication site (DOI): 10.1017/S1047951110000557 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20426895 ● Search Scopus @ Elsevier (PMID): 20426895 ● Search Scopus @ Elsevier (DOI): 10.1017/S1047951110000557 (DOI: 10.1017/S1047951110000557, PubMed: 20426895)
69.	Yasunobu Hayabuchi, Miki Inoue, Noriko Watanabe, Miho Sakata, ManalMH Nabo, Tetsuya Kitagawa, Takashi Kitaichi and Shoji Kagami : Assessment of systemic-pulmonary collateral arteries in children with cyanotic congenital heart disease using multidetector-row computed tomography: Comparison with conventional angiography, International Journal of Cardiology, Vol.138, No.3, 266-271, 2010. (要約) The present study aimed to assess the feasibility of multidetector-row computed tomography (MDCT) for the evaluation of systemic-pulmonary collateral (SPC) arteries in children with congenital heart disease associated with reduced pulmonary blood flow. Forty-eight consecutive patients (mean age 9+/-5 months; range, 0-30 months) underwent MDCT angiography of the thorax with a 16-detector row scanner prior to cardiac catheterization and operation. Conventional angiographic findings were used as a gold standard for the detection of SPC vessels. Findings on CT angiograms, including CT scans, maximum intensity projections, and three-dimensional volume-rendered images, were used to evaluate depiction of SPC arteries. Quantification of measurements at the SPC artery diameter was evaluated independently on MDCT and conventional invasive angiography. Among the 48 patients, 115 SPC arteries were identified with conventional angiography, and 94 SPC arteries were identified with MDCT. In 89 (77%) vessels, concordant findings were observed with both modalities, with adequate depiction in 53 vessels and suboptimal depiction in 36 vessels. In 26 (23%) vessels, MDCT was unable to identify SPC arteries. Further, CT angiography resulted in the false-positive identification of vessels in 5 cases. There was an excellent correlation between MDCT- and conventional angiography-based measurement of SPC vessel diameter (R(2)=0.83), although a systematic overestimation was observed with MDCT (bias 0.19+/-0.74 mm). This study demonstrates that MDCT is a potentially useful tool, which may have implications for planning percutaneous interventions and surgical repair in the future. (キーワード) Collateral Circulation / Coronary Angiography / Cyanosis / Female / Heart Defects, Congenital / Humans / 小児 (infant) / Infant, Newborn / Male / Pulmonary Artery / Pulmonary Circulation / Reference Standards / Reproducibility of Results / Tomography, X-Ray Computed (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ijcard.2008.08.018 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18790544 ● Search Scopus @ Elsevier (PMID): 18790544 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ijcard.2008.08.018 (DOI: 10.1016/j.ijcard.2008.08.018, PubMed: 18790544)
70.	Tatsushi Miyazaki, Katsunori Tatara, Kazuhiro Mori, Miki Inoue, Yasunobu Hayabuchi and Shoji Kagami : Increased mid-left ventricular rotation in patients with Duchenne muscular dystrophy using two-dimensional speckle tracking echocardiography, Journal of Echocardiography, Vol.8, No.1, 14-24, 2010. (キーワード) Duchenne muscular dystrophy / Speckle tracking / Rotation / Heart rate variability / Autonomic function (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s12574-009-0025-1 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1572543026083810560 ● Search Scopus @ Elsevier (DOI): 10.1007/s12574-009-0025-1 (DOI: 10.1007/s12574-009-0025-1, CiNii: 1572543026083810560)
71.	Yasunobu Hayabuchi : Coronary arteriovenous fistula: Direct connection of the proximal circumflex artery to the coronary sinus, Pediatric Cardiology, Vol.31, No.1, 168-169, 2010. (キーワード) Arteriovenous Fistula / Child / Coronary Sinus / Coronary Vessel Anomalies / Female / Humans / Imaging, Three-Dimensional / Tomography, X-Ray Computed (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00246-009-9555-6 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19841964 ● Search Scopus @ Elsevier (PMID): 19841964 ● Search Scopus @ Elsevier (DOI): 10.1007/s00246-009-9555-6 (DOI: 10.1007/s00246-009-9555-6, PubMed: 19841964)
72.	Manal Helmy Mohamed Nabo, Yasunobu Hayabuchi, Miki Inoue, Noriko Watanabe, Miho Sakata and Shoji Kagami : Assessment of modified Blalock-Taussig shunt in children with congenital heart disease using multidetector-row computed tomography, Heart and Vessels, Vol.25, No.6, 529-535, 2010. (要約) The purpose of this study was to assess the feasibility of multidetector-row computed tomography (MDCT) for the evaluation of modified Blalock-Taussig (B-T) shunt in children with congenital heart disease associated with reduced pulmonary blood flow. A total of 25 consecutive patients (mean age, 2.6 ± 3.6 years; range, 2 months-16 years) underwent MDCT angiography of the thorax with a 16-detector row scanner prior to cardiac catheterization. A total of 39 shunts (right, 22; left, 17) were included in the study. Conventional angiographic findings were used as the gold standard for the detection of B-T shunts. Shunt diameter was measured quantitatively and independently at four sites (the subclavian artery site, the pulmonary artery site, the widest site, and the stenotic site) on MDCT and on conventional invasive angiography. All B-T shunts were depicted on multiplanar reconstruction (MPR), maximum intensity projection (MIP), curved planar reconstruction (CPR), and three-dimensional volume-rendered (VR) images, enabling evaluation in all patients except for one with occluded shunt. There were excellent correlations between MDCT- and conventional angiography-based measurements of shunt diameter at the subclavian artery site, pulmonary artery site, and the widest site (R² = 0.46, 0.74 and 0.64, respectively; p < 0.0001 for each), although systematic overestimation was observed for MDCT (mean percentage of overestimation, 23.1 ± 32.4%). Stenotic site diameter and degree of stenosis showed a mild correlation (R² = 010 and 0.25, respectively; p < 0.01 for each). This study demonstrates that MDCT is a promising tool for the detection of lesions in B-T shunts. (キーワード) Adolescent / Blalock-Taussig Procedure / Child / Child, Preschool / Feasibility Studies / Female / Heart Defects, Congenital / Humans / Infant / Japan / Linear Models / Male / Predictive Value of Tests / Pulmonary Artery / Pulmonary Circulation / Regional Blood Flow / Subclavian Artery / Time Factors / Tomography, X-Ray Computed / Treatment Outcome (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00380-010-0007-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 20878166 ● Search Scopus @ Elsevier (PMID): 20878166 ● Search Scopus @ Elsevier (DOI): 10.1007/s00380-010-0007-2 (DOI: 10.1007/s00380-010-0007-2, PubMed: 20878166)
73.	Miki Inoue, Yasunobu Hayabuchi, Kazuhiro Mori, Katsunori Tatara and Shoji Kagami : Autonomic function in patients with Duchenne muscular dystrophy, Pediatrics International, Vol.51, No.1, 33-40, 2009. (要約) Assessing autonomic function is important for patients with chronic heart failure, but the way that autonomic function changes in patients with Duchenne muscular dystrophy (DMD) and correlates with other clinical parameters during their young age is not clearly known. Heart rate variability (HRV) during ambulatory electrocardiogram (ECG) was performed in 57 DMD patients (130 recordings) who were not receiving medication (mean age 15.3 +/- 4.5 years). The data were compared with the serum levels of brain natriuretic peptide (BNP), the shortening fraction (SF) of the left ventricle on echocardiography, and simple parameters of heart rate from 24 h ambulatory ECG. Among four parameters of HRV measurements (high frequency [HF]; percentage of adjacent normal R-R intervals that were >50 ms different for the entire 24 h recording [%RR50]; ratio of low to high frequency [LF/HF]; and standard deviation for all normal R-R intervals for the entire 24 h recording [SDNN]), SDNN was most frequently abnormal. Even when SF was normal, a significant percentage of patients exhibited, abnormal parasympathetic activity (HF, %RR50: 74%, 78%, respectively), sympathetic activity (LF/HF, 43%), and SDNN (96%). Similarly, even if serum BNP levels were normal, 86%, 89%, 59%, and 97% of the patients displayed abnormal autonomic function on these measurements, respectively. Mean heart rate at night most accurately predicted abnormality of SDNN. When the cut-off point for mean heart rate at night was 71 beats/min, the sensitivity and specificity of this parameter for predicting abnormal SDNN was 94% and 85%, respectively (P < 0.0001). In DMD, autonomic function, especially SDNN, was frequently abnormal, although conventional clinical examinations of cardiac function (BNP levels and SF) were normal. It is proposed that mean heart rate during night could be used as a simple measurement for evaluation of autonomic function. (キーワード) Adolescent / Adult / Autonomic Nervous System / Child / Heart Rate / Humans / Muscular Dystrophy, Duchenne (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1442-200X.2008.02656.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19371275 ● Search Scopus @ Elsevier (PMID): 19371275 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1442-200X.2008.02656.x (DOI: 10.1111/j.1442-200X.2008.02656.x, PubMed: 19371275)
74.	Noriko Watanabe, Yasunobu Hayabuchi, Miki Inoue, Miho Sakata, Nabo Mohamed Helmy Manal, Ryuji Nakagawa, Takahiko Saijo and Shoji Kagami : Tracheal compression due to an elongated aortic arch in patients with congenital heart disease: evaluation using multidetector-row CT, Pediatric Radiology, Vol.39, No.10, 1048-1053, 2009. (要約) The airway can become obstructed as a result of compression by an elongated aortic arch. In this study we evaluated tracheal compression using multidetector-row CT in patients with congenital heart disease and an elongated aortic arch. The trachea was measured at the level of the aortic arch in 205 children and young adults and then the severity of tracheal compression was determined by measuring the tracheal diameter ratio (short axis diameter/long axis diameter). Patients were divided as follows: group I (normal aortic arch; n=166), group II (transversely running aortic arch; n=22), and group III (elongated aortic arch; n=17). From the viewpoint of the relationship of the great arteries, group II had D-malposition, and group III had L-malposition. Age, height, weight and body surface area were significantly correlated with the short and long axis diameter in group I. There was a negative correlation between tracheal diameter ratio and the physical size parameters. The tracheal diameter ratio in group III was 0.50+/-0.13, which was significantly lower than in groups I and II (P<0.01 and 0.05, respectively). Even apparently asymptomatic patients with an elongated aortic arch can have tracheal compression. An elongated aortic arch may be a useful predictor of tracheal compression. (キーワード) Adolescent / Aorta, Thoracic / Aortic Arch Syndromes / Aortography / Child / Child, Preschool / Female / Heart Defects, Congenital / Humans / Infant / Infant, Newborn / Male / Reproducibility of Results / Retrospective Studies / Sensitivity and Specificity / Tomography, X-Ray Computed / Tracheal Stenosis / Young Adult (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00247-009-1319-1 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19547963 ● Search Scopus @ Elsevier (PMID): 19547963 ● Search Scopus @ Elsevier (DOI): 10.1007/s00247-009-1319-1 (DOI: 10.1007/s00247-009-1319-1, PubMed: 19547963)
75.	Miho Sakata, Yasunobu Hayabuchi, Miki Inoue and Shoji Kagami : Stenting of ductus arteriosus in a neonate with truncus arteriosus and interrupted aortic arch associated with a right aortic arch, Pediatric Cardiology, Vol.30, No.8, 1180-1183, 2009. (要約) This report describes a case in which successful stenting of ductus arteriosus (DA) was performed for a 27-day-old boy with truncus arteriosus (TA) and interrupted aortic arch (IAA). The patent DA was associated with a right aortic arch. During the balloon catheter crossing of the ductus, the DA and descending aorta shifted toward the left side, making appropriate stent placement difficult. Additionally, the DA was longer than in previously reported cases with left aortic arch, thus requiring a longer stent. This experience suggests that DA stenting in neonates with TA and IAA averts surgical repair during the early neonatal period. (キーワード) Angiography / Angioplasty, Balloon / Aorta, Thoracic / Ductus Arteriosus, Patent / Humans / Infant, Newborn / Male / Stents / Tomography, X-Ray Computed / Truncus Arteriosus, Persistent (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00246-009-9522-2 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 19705182 ● Search Scopus @ Elsevier (PMID): 19705182 ● Search Scopus @ Elsevier (DOI): 10.1007/s00246-009-9522-2 (DOI: 10.1007/s00246-009-9522-2, PubMed: 19705182)
76.	Yasunobu Hayabuchi, GB Willars, NB Standen and NW Davies : Insulin-like growth factor-I inhibits rat arterial K(ATP) channels through pI 3-kinase, Biochemical and Biophysical Research Communications, Vol.374, No.4, 742-746, 2008. (要約) Since, in addition to its growth-promoting actions, insulin-like growth factor-I (IGF-I) has rapid vasoactive actions, we investigated the effects of IGF-I on whole-cell ATP-sensitive K(+) (K(ATP)) currents of rat mesenteric arterial smooth muscle cells. IGF-I (10 or 30 nM) reduced K(ATP) currents activated by pinacidil or a membrane permeant cAMP analogue. Inhibition of phospholipase C, protein kinase C, protein kinase A, mitogen-activated protein kinase or mammalian target of rapamycin (mTOR) did not prevent the action of IGF-I. However, inhibition of K(ATP) currents by IGF-I was abolished by the tyrosine kinase inhibitor genistein or the phosphoinositide 3-kinase inhibitors, LY 294002 and wortmannin. Intracellular application of either phosphatidylinositol 4,5-bisphosphate (PIP(2)) or phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) increased the K(ATP) current activated by pinacidil and abolished the inhibitory effect of IGF-I. Thus, we show regulation of arterial K(ATP) channels by polyphosphoinositides and report for the first time that IGF-I inhibits these channels via a phosphoinositide 3-kinase-dependent pathway. (キーワード) Androstadienes / Animals / Arteries / Chromones / Cyclic AMP-Dependent Protein Kinases / Genistein / Insulin-Like Growth Factor I / KATP Channels / Male / Mitogen-Activated Protein Kinases / Morpholines / Myocytes, Smooth Muscle / Phosphatidylinositol 3-Kinases / Phosphatidylinositol 4,5-Diphosphate / Phosphatidylinositol Phosphates / Phosphoinositide Phospholipase C / Pinacidil / Protein Kinase C / Protein Kinases / Protein-Tyrosine Kinases / Rats / Rats, Wistar / TOR Serine-Threonine Kinases (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.bbrc.2008.07.100 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18671941 ● Search Scopus @ Elsevier (PMID): 18671941 ● Search Scopus @ Elsevier (DOI): 10.1016/j.bbrc.2008.07.100 (DOI: 10.1016/j.bbrc.2008.07.100, PubMed: 18671941)
77.	Tatsushi Miyazaki, Katsunori Tatara, Kazuhiro Mori, Miki Inoue, Yasunobu Hayabuchi and Shoji Kagami : Segmental Myocardial Strain of the Left Ventricle in Patients With Duchenne Muscular Dystrophy Using Two-Dimensional Speckle Tracking Echocardiography, Journal of Echocardiography, Vol.6, No.4, 100-108, 2008. (キーワード) myocardial strain / speckle tracking echocardiography / Duchenne muscular dystrophy / cardiomyopathy (出版サイトへのリンク) ● Publication site (DOI): 10.2303/jecho.6.100 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1570572700950764288 ● Search Scopus @ Elsevier (DOI): 10.2303/jecho.6.100 (DOI: 10.2303/jecho.6.100, CiNii: 1570572700950764288)
78.	Yasunobu Hayabuchi, Miki Inoue and Shoji Kagami : Rare venous connection causing severe hypoxia after Fontan operation, Interactive Cardiovascular and Thoracic Surgery, Vol.7, No.4, 718-719, 2008. (要約) We describe a rare case of cyanosis following the Fontan operation with right-to-left shunting at the venous level, that is, an azygos venous to pulmonary venous connection. Few cases with partial anomalous pulmonary venous connection to azygos vein have been reported; however, there have been no reports describing the connection from azygos vein to pulmonary vein, which results in desaturation after Fontan operation. Multidetector-row computed tomography (MDCT) was a useful tool to depict this vascular malformation. (キーワード) Anoxia / Azygos Vein / Child / Female / Fontan Procedure / Humans / Ligation / Phlebography / Pulmonary Veins / Severity of Illness Index / Tomography, X-Ray Computed / Treatment Outcome / Vascular Malformations / Vascular Surgical Procedures (出版サイトへのリンク) ● Publication site (DOI): 10.1510/icvts.2008.175596 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 18407962 ● Search Scopus @ Elsevier (PMID): 18407962 ● Search Scopus @ Elsevier (DOI): 10.1510/icvts.2008.175596 (DOI: 10.1510/icvts.2008.175596, PubMed: 18407962)
79.	Yasunobu Hayabuchi, Kazuhiro Mori, Tetsuya Kitagawa, Miki Inoue and Shoji Kagami : Accurate quantification of pulmonary artery diameter in patients with cyanotic congenital heart diease using multidetector-row computed tomography, American Heart Journal, Vol.154, No.4, 783-788, 2007. (要約) The purpose of this study is to assess the feasibility of multidetector-row computed tomography (MDCT) for the quantitative evaluation of pulmonary artery morphology in children with congenital heart disease that is associated with reduced pulmonary blood flow. Quantification of measurements at the pulmonary artery annulus and right and left pulmonary arteries, and detection of stenoses exceeding 30% diameter reduction were evaluated independently on MDCT and conventional invasive angiography in 56 MDCT scans of 44 children. The diameters of the right and left pulmonary arteries were measured just proximal to the first branch and at the site of maximum stenosis. There was an excellent correlation between MDCT and conventional pulmonary angiography in quantifying the diameter of the right and left pulmonary arteries (R2 = 0.85 and 0.82, respectively), although a systematic overestimation was observed on MDCT (bias 0.38 +/- 0.49 and 0.28 +/- 0.54 mm, respectively). The pulmonary artery annulus diameter on MDCT scans moderately correlated with the measurement on conventional angiograms (R2 = 0.48). Multidetector-row computed tomography correctly detected 15 of 16 pulmonary artery stenotic lesions that were detected on invasive angiography. There was an excellent correlation between MDCT and conventional angiograms with respect to evaluation of stenotic sites (R2 = 0.82). Our findings showed a strong correlation of vessel diameter measurements between MDCT and invasive pulmonary angiography. This study demonstrates the feasibility of MDCT in assessing pulmonary artery size and morphology. (キーワード) Child, Preschool / Constriction, Pathologic / Coronary Angiography / Feasibility Studies / Female / Heart Defects, Congenital / Humans / Infant / Infant, Newborn / Male / Pulmonary Artery / Pulmonary Circulation / Tomography, X-Ray Computed (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ahj.2007.06.004 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17893009 ● Search Scopus @ Elsevier (PMID): 17893009 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ahj.2007.06.004 (DOI: 10.1016/j.ahj.2007.06.004, PubMed: 17893009)
80.	Yasunobu Hayabuchi, Kazuhiro Mori and Shoji Kagami : Virtual endoscopy using multidetector-row CT for coil occlusion of patent ductus arteriosus, Catheterization and Cardiovascular Interventions, Vol.70, No.3, 434-439, 2007. (要約) The objective of this study was to report the clinical value of virtual endoscopy using multidetector-row CT (MDCT) for coil occlusion of patent ductus arteriosus (PDA). We studied 10 consecutive patients with PDA undergoing cardiac catheterization and coil occlusion. All patients had previously undergone MDCT, and subsequently underwent transcatheter closure of ductus. MDCT evaluations were performed again in 1-3 months after occlusion. Virtual endoscopy showed the anatomy of the orifice of the ductus and spatial relations of adjacent structures from both the aortic and pulmonary sides in all patients. We were able to observe the inner space, and fly through the PDA. This approach is the virtual view of the catheter advancing during coil occlusion. Following occlusion, visualization of the coil can also be established by viewing from inside. Coil protrusion into the aortic and pulmonary sides was clearly observed. Virtual endoscopy provides unique information regarding the ductal lumen that is of use for the coil occlusion of PDA. (キーワード) Adolescent / Adult / Angioscopy / Balloon Occlusion / Child / Child, Preschool / Ductus Arteriosus, Patent / Echocardiography, Doppler / Female / Follow-Up Studies / Humans / Male / Prosthesis Implantation / Retrospective Studies / Tomography, X-Ray Computed / Treatment Outcome / User-Computer Interface (出版サイトへのリンク) ● Publication site (DOI): 10.1002/ccd.21108 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17380493 ● Search Scopus @ Elsevier (PMID): 17380493 ● Search Scopus @ Elsevier (DOI): 10.1002/ccd.21108 (DOI: 10.1002/ccd.21108, PubMed: 17380493)
81.	Yasunobu Hayabuchi, Kazuhiro Mori, Tetsuya Kitagawa, Sakata Miho and Shoji Kagami : Polytetrafluoroethylene graft calcification in patients with surgically repaired congenital heart disease:Evaluation using multidetector-row computed tomography, American Heart Journal, Vol.153, No.5, 806e1-806e8, 2007. (要約) Noninvasive determination of calcified prosthetic polytetrafluoroethylene (PTFE) is important in improving risk stratification. The purpose of this study is to assess the feasibility of multidetector-row computed tomography (MDCT) for the evaluation of PTFE calcification in patients with surgically repaired congenital heart disease and to evaluate the development and characteristics of calcification for specific surgical procedures. Seventy-six implanted PTFE grafts in 47 patients were evaluated by MDCT (Aquillion 16, Toshiba Corporation, Tokyo, Japan). Explanted PTFE grafts were evaluated histologically in 4 patients who underwent reoperation after MDCT scans. Calcification of prosthetic PTFE was detected in 5 of 29 cases (17%) for ventricular septal defect (VSD) patches, 26 of 32 (81%) for right ventricular outflow tract (RVOT) prosthesis, 2 of 8 (25%) for atrial septal patches of the Fontan procedure, and 7 of 7 (100%) for extracardiac conduits of total cavopulmonary connection. The CT attenuation of PTFE revealed significantly different values for VSD patches (114 +/- 61 Hounsfield units [HU]), RVOT prosthesis (243 +/- 132 HU), atrial septal patches (163 +/- 161 HU), and extracardiac conduits (230 +/- 29 HU) (P < .0001). The CT density value of VSD patches was significantly lower than those of RVOT grafts and extracardiac conduits (P < .05). The MDCT findings were consistent with histologic analysis in the evaluation of calcification. This study demonstrates that MDCT enables the evaluation of prosthetic PTFE graft calcification; PTFE grafts in 4 different implantation sites demonstrated distinctive features and the prevalence of calcification. (キーワード) Adolescent / Adult / Blood Vessel Prosthesis / Calcinosis / Child / Child, Preschool / Equipment Failure Analysis / Female / Fontan Procedure / Heart Defects, Congenital / Heart Valve Prosthesis / Heart, Artificial / Humans / Male / Phantoms, Imaging / Polytetrafluoroethylene / Tomography, X-Ray Computed / Ventricular Outflow Obstruction (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.ahj.2007.01.035 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17452157 ● Search Scopus @ Elsevier (PMID): 17452157 ● Search Scopus @ Elsevier (DOI): 10.1016/j.ahj.2007.01.035 (DOI: 10.1016/j.ahj.2007.01.035, PubMed: 17452157)
82.	Kazuhiro Mori, Yasunobu Hayabuchi, Miho Sakata, Ryuji Nakagawa, Shoji Kagami, Katsunori Tatara, Y Hirayama and Y Abe : Myocardial strain imaging for early detection of cardiac involvement in patients with Duchenne's progressive muscular dystrophy., Echocardiography, Vol.24, No.6, 598-608, 2007. (要約) In patients with Duchenne's progressive muscular dystrophy (DMD), myocardial fibrosis begins from the epicardial half of the left ventricular posterior wall. Myocardial strain imaging by tissue Doppler echocardiography is a new method for assessing regional myocardial function. We hypothesized that this method might be useful for the early detection of subclinical myocardial involvement in DMD patients. Myocardial radial strain of the left ventricle was measured in 25 DMD patients (age: 14.8 +/- 3.1 years) with a normal left ventricular shortening fraction and 25 age-matched healthy controls. Peak systolic radial strain of the posterior wall in a short-axis view of the left ventricle was significantly lower in DMD patients compared to control subjects (P < 0.0001). In the interventricular septum, peak systolic radial strain was not significantly different between the two groups. Receiver operating characteristic curve analysis differentiated DMD patients from control patients with 92% sensitivity and 92% specificity, when the cutoff value for systolic peak strain of the posterior wall was 61%. When radial strain was measured separately for the inner and outer halves of the posterior wall, a systolic negative strain was more frequently observed in the outer half than in the inner half of the posterior wall (6/25 vs. 0/25, P < 0.05). Myocardial strain imaging in DMD patients was characterized by decreased peak systolic strain of the posterior wall despite normal standard echocardiographic findings. Strain measurement might be useful for early detection of subtle regional myocardial dysfunction. (キーワード) Adolescent / Adult / Child / Early Diagnosis / Echocardiography, Doppler / Heart / Heart Diseases / Heart Ventricles / Humans / Muscular Dystrophy, Duchenne / Observer Variation / Predictive Value of Tests / ROC Curve / Sensitivity and Specificity / Time Factors / Ventricular Dysfunction, Left (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1540-8175.2007.00437.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 17584199 ● Search Scopus @ Elsevier (PMID): 17584199 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1540-8175.2007.00437.x (DOI: 10.1111/j.1540-8175.2007.00437.x, PubMed: 17584199)
83.	阪田美穂, 早渕康信, 森一博, 中川竜二, 田口義行, 香美祥二 : 多源性心房性頻拍症の2乳児例, 小児科臨床, Vol.59, No.10, 2135-2141, 2006年. (キーワード) 多源性心房性頻拍 / アミオダロン / 心拍コントロール / 心房細動 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1520854805673385984 (CiNii: 1520854805673385984)
84.	Yasunobu Hayabuchi, Yutaka Nakaya, Yasui Sonoko, Kazuaki Mawatari, Kazuhiro Mori, Suzuki Mitsujiro and Shoji Kagami : Angiotensin II activates intermediate-conductance Ca²⁺-activated K⁺ channels in arterial smooth muscle cells., Journal of Molecular and Cellular Cardiology, Vol.41, No.6, 972-929, 2006. (要約) Angiostensin II (Ang II) regulates the migration and proliferation of vascular smooth muscle cells. Recent studies indicate that intermediate-conductance Ca2+ -activated K+ (IKca) channels have an important role in cell migration and proliferation. It is not known, however, whether the action of Ang II is linked to IKca channel regulation. Here, we investigated the modulation of IKca channels by Ang II in artery smooth muscle cells. Functional IKca channel expression in cultured embryonic rat aorta smooth muscle (A10) cells was studied using the patch-clamp technique. These cells predominantly express IKca channels. In contrast, large-conductance Ca2+ -activated K+ (BKca) currents were rarely observed in excised patches. Ang II increased the IKca current in a contration-dependent manner. Losartan (1.0 microM), an AT1 selective antagonist, abolished the activation of IKca channels by Ang II. Pretreatment with 100 microM myristoylated protein kinase C inhibitor peptide 20-28 or 10 microM GF109203X completely abolished the AngII-induced activation of IKca currents, whereas the action of Ang II was not prevented in the presence of 100 microM Rp-cyclic 3', 5'-hydrogen phosphotiate adenosine triethylammonium, a protein kinase A inhibitor, or 1.0 microM KT-5823, a protein kinase G inhibitor. A membrane permeant analogue of diacylglycerol 1, 2-dioctanoyl-sn-glycerol (10 microM) induced the activation of IKca currents. These data suggest that Ang II activates IKca channels through the activation of protein kinase C, and the AT1 receptor is involved in the regulation of these channels. (キーワード) Angiotensin II / Angiotensin II Type 1 Receptor Blockers / Animals / Cells, Cultured / Diglycerides / Enzyme Inhibitors / Intermediate-Conductance Calcium-Activated Potassium Channels / Losartan / Muscle, Smooth, Vascular / Myocytes, Smooth Muscle / Patch-Clamp Techniques / Protein Kinase C / Rats / Receptor, Angiotensin, Type 1 / Signal Transduction (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.yjmcc.2006.07.010 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 16919291 ● Search Scopus @ Elsevier (PMID): 16919291 ● Search Scopus @ Elsevier (DOI): 10.1016/j.yjmcc.2006.07.010 (DOI: 10.1016/j.yjmcc.2006.07.010, PubMed: 16919291)
85.	Miki Inoue, Kazuhiro Mori, Yasunobu Hayabuchi, Katsunori Tatara and Shoji Kagami : Mean heart rate at noght as a predictor for the evaluation of autonomic function in patietns with Duchenne progressive muscular dystrophy, Eur Heart J, Vol.27, suppl-685, 2006.
86.	Sakata Miho, Kazuhiro Mori, Yasunobu Hayabuchi, Suzuki Mitsujiro, Ryuji Nakagawa, Shoji Kagami and Baba Hirotaka : Myocardial systolic strain in normal children using a tissue tracking system, Journal of Echocardiography, Vol.4, No.1, 19-24, 2006. (キーワード) tissue tracking system / pattern matching algorithm / regional myocardial strain (出版サイトへのリンク) ● Publication site (DOI): 10.2303/jecho.4.19 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390001205232565248 ● Search Scopus @ Elsevier (DOI): 10.2303/jecho.4.19 (DOI: 10.2303/jecho.4.19, CiNii: 1390001205232565248)
87.	LJ Sampson, Yasunobu Hayabuchi, NB Standen and C Dart : Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels., Circulation Research, Vol.95, No.10, 1012-1018, 2004. (要約) Arterial ATP-sensitive K+ (K(ATP)) channels are critical regulators of vascular tone, forming a focal point for signaling by many vasoactive transmitters that alter smooth muscle contractility and so blood flow. Clinically, these channels form the target of antianginal and antihypertensive drugs, and their genetic disruption leads to hypertension and sudden cardiac death through coronary vasospasm. However, whereas the biochemical basis of K(ATP) channel modulation is well-studied, little is known about the structural or spatial organization of the signaling pathways that converge on these channels. In this study, we use discontinuous sucrose density gradients and Western blot analysis to show that K(ATP) channels localize with an upstream signaling partner, adenylyl cyclase, to smooth muscle membrane fractions containing caveolin, a protein found exclusively in cholesterol and sphingolipid-enriched membrane invaginations known as caveolae. Furthermore, we show that an antibody against the K(ATP) pore-forming subunit, Kir6.1 co-immunoprecipitates caveolin from arterial homogenates, suggesting that Kir6.1 and caveolin exist together in a complex. To assess whether the colocalization of K(ATP) channels and adenylyl cyclase to smooth muscle caveolae has functional significance, we disrupt caveolae with the cholesterol-depleting agent, methyl-beta-cyclodextrin. This reduces the cAMP-dependent protein kinase A-sensitive component of whole-cell K(ATP) current, indicating that the integrity of caveolae is important for adenylyl cyclase-mediated channel modulation. These results suggest that to be susceptible to protein kinase A-dependent activation, arterial K(ATP) channels need to be localized in the same lipid compartment as adenylyl cyclase; the results also provide the first indication of the spatial organization of signaling pathways that regulate K(ATP) channel activity. (キーワード) ATP-Binding Cassette Transporters / Adenosine Triphosphate / Adenylate Cyclase / Animals / Aorta / Calcitonin Gene-Related Peptide / Caveolae / Caveolin 1 / Caveolins / Cell Compartmentation / Cell Fractionation / Cholesterol / Cyclic AMP-Dependent Protein Kinases / Glyburide / Guanosine Diphosphate / Ion Transport / Isoenzymes / KATP Channels / Male / Membrane Lipids / Mesenteric Arteries / Muscle, Smooth, Vascular / Myocytes, Smooth Muscle / Patch-Clamp Techniques / Peptide Fragments / Pinacidil / Potassium / Potassium Channels, Inwardly Rectifying / Propranolol / Rats / Rats, Wistar / Sphingolipids / Theophylline / Thionucleotides (出版サイトへのリンク) ● Publication site (DOI): 10.1161/01.RES.0000148634.47095.ab (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 15499025 ● Search Scopus @ Elsevier (PMID): 15499025 ● Search Scopus @ Elsevier (DOI): 10.1161/01.RES.0000148634.47095.ab (DOI: 10.1161/01.RES.0000148634.47095.ab, PubMed: 15499025)
88.	Kazuhiro Mori, Tetsuya Manabe, Masaki Nii, Yasunobu Hayabuchi, Yasuhiro Kuroda and K. Tatara : Plasma levels of natriuretic peptide and echocardiographic parameters in patients with Duchenne's progressive muscular dystrophy., Pediatric Cardiology, Vol.23, No.2, 160-166, 2002. (要約) We investigated the relationship between plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels and systolic and diastolic cardiac function, determined by echocardiography, in 63 patients with Duchenne's progressive muscular dystrophy (DMD) (age range 8-21 years). The relationship between shortening fraction of the left ventricle and ANP and BNP levels was curvilinear rather than linear: When the shortening fraction was >15%, increases in ANP and BNP levels were minimal. However, if the shortening fraction was <15%, both natriuretic peptide levels increased dramatically. Stepwise regression analysis revealed that only the deceleration time of the early diastolic filling wave predicted plasma BNP concentration among various diastolic echocardiographic parameters determined by mitral flow. Three patients died of cardiac dysfunction during a 2-year follow-up period. These patients had a severely decreased deceleration time (<65% of normal) in association with increases in both natriuretic peptide levels. In conclusion, plasma ANP and BNP levels are not sensitive markers for the early detection of cardiac systolic dysfunction in patients with DMD. However, in patients with systolic dysfunction, an increase in the concentrations of these peptides, associated with a decrease in the deceleration time of early diastolic filling, suggests poor prognosis. (キーワード) Duchenne's muscular dystrophy / Natriuretic peptides / Diastole / Transmitral Doppler filling (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s00246-001-0040-0 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11889527 ● Summary page in Scopus @ Elsevier: 2-s2.0-0036517436 (DOI: 10.1007/s00246-001-0040-0, PubMed: 11889527, Elsevier: Scopus)
89.	枝川卓二, 真鍋哲也, 新居正基, 早渕康信, 森一博, 黒田𣳾弘 : 1歳未満で大動脈弁逸脱を合併した漏斗部心室中隔欠損例の検討, 小児科臨床, Vol.55, No.1, 116-118, 2002年.
90.	Yasunobu Hayabuchi, NB Standen and NW. Davies : Angiotensin II inhibits and alters kinetics of voltage-gated K(+) channels of rat arterial smooth muscle., American Journal of Physiology, Heart and Circulatory Physiology, Vol.281, No.6, 2480-2489, 2001. (要約) The vasoconstrictor angiotensin II (ANG II) inhibits several types of K(+) channels. We examined the inhibitory mechanism of ANG II on voltage-gated K(+) (K(V)) currents (I(K(V))) recorded from isolated rat arterial smooth muscle using patch-clamp techniques. Application of 100 nM ANG II accelerated the activation of I(K(V)) but also caused inactivation. These effects were abolished by the AT(1) receptor antagonist losartan. The protein kinase A (PKA) inhibitor Rp-cyclic 3',5'-hydrogen phosphothioate adenosine (100 microM) and an analog of diacylglycerol, 1,2-dioctanyoyl-rac-glycerol (2 microM), caused a significant reduction of I(K(V)). Furthermore, the combination of 5 microM PKA inhibitor peptide 5-24 (PKA-IP) and 100 microM protein kinase C (PKC) inhibitor peptide 19-27 (PKC-IP) prevented the inhibition by ANG II, although neither alone was effective. The ANG II effect seen in the presence of PKA-IP remained during addition of the Ca(2+)-dependent PKC inhibitor Gö6976 (1 microM) but was abolished in the presence of 40 microM PKC-epsilon translocation inhibitor peptide. These results demonstrate that ANG II inhibits K(V) channels through both activation of PKC-epsilon and inhibition of PKA. (キーワード) Angiotensin II / Animals / Antihypertensive Agents / Cyclic AMP / Cyclic AMP-Dependent Protein Kinases / Diglycerides / Enzyme Inhibitors / Isoenzymes / Kinetics / Losartan / Male / Membrane Potentials / Mesenteric Arteries / Muscle, Smooth, Vascular / Patch-Clamp Techniques / Peptides / Potassium Channels, Voltage-Gated / Protein Kinase C / Protein Kinase C-epsilon / Rats / Rats, Wistar / Thionucleotides / Vasoconstrictor Agents (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11709415 ● Summary page in Scopus @ Elsevier: 2-s2.0-0035662111 (PubMed: 11709415, Elsevier: Scopus)
91.	Yasunobu Hayabuchi, C Dart and NB. Standen : Evidence for involvement of A-kinase anchoring protein in activation of rat arterial K_ATP channels by protein kinase A, The Journal of Physiology, Vol.536, No.2, 421-427, 2001. (要約) 1. We have investigated the possible role of A-kinase anchoring proteins (AKAPs) in protein kinase A (PKA) signalling to ATP-sensitive K+ (K(ATP)) channels of rat isolated mesenteric arterial smooth muscle cells using whole-cell patch clamp and peptides that inhibit PKA-AKAP binding. 2. Intracellular Ht31 peptide (20 microM), which inhibits the PKA-AKAP interaction, blocked K(ATP) current activation by either dibutyryl cAMP or calcitonin gene-related peptide. Ht31-proline (20 microM), which does not inhibit PKA binding to AKAP, did not block K(ATP) current activation. 3. Ht31 reduced K(ATP) current activated by pinacidil and also prevented its inhibition by Rp-cAMPS, effects consistent with Ht31 blocking steady-state K(ATP) channel activation by PKA. However, Ht31 did not prevent K(ATP) current activation by the catalytic subunit of PKA. 4. An antibody to the RII subunit of PKA showed localization of PKA near to the cell membrane. Our results provide evidence that both steady-state and receptor-driven activation of K(ATP) channels by PKA involve the localization of PKA by an AKAP. (キーワード) Adenosine Triphosphate / Amino Acid Sequence / Animals / Bucladesine / Calcitonin Gene-Related Peptide / Carrier Proteins / Cell Membrane / Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit / Cyclic AMP-Dependent Protein Kinases / Ion Channel Gating / Male / Mesenteric Arteries / Molecular Sequence Data / Muscle, Smooth, Vascular / Patch-Clamp Techniques / Peptide Fragments / Potassium Channels / Rats / Rats, Wistar (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1469-7793.2001.0421c.xd (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11600677 ● Search Scopus @ Elsevier (PMID): 11600677 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1469-7793.2001.0421c.xd (DOI: 10.1111/j.1469-7793.2001.0421c.xd, PubMed: 11600677)
92.	Yasunobu Hayabuchi, NW Davies and NB Standen : Angiotensin II inhibits rat arterial K_ATP channels by inhibiting steady-state protein kinase A activity and activating protein kinase Cϵ, The Journal of Physiology, Vol.530, No.2, 193-205, 2001. (要約) We used whole-cell patch clamp to investigate steady-state activation of ATP-sensitive K+ channels (KATP) of rat arterial smooth muscle by protein kinase A (PKA) and the pathway by which angiotensin II (Ang II) inhibits these channels. Rp-cAMPS, an inhibitor of PKA, did not affect KATP currents activated by pinacidil when the intracellular solution contained 0.1 mM ATP. However, when ATP was increased to 1.0 mM, inhibition of PKA reduced KATP current, while the phosphatase inhibitor calyculin A caused a small increase in current. Ang II (100 nM) inhibited KATP current activated by the K+ channel opener pinacidil. The degree of inhibition was greater with 1.0 mM than with 0.1 mM intracellular ATP. The effect of Ang II was abolished by the AT1 receptor antagonist losartan. The inhibition of KATP currents by Ang II was abolished by a combination of PKA inhibitor peptide 5-24 (5 microM) and PKC inhibitor peptide 19-27 (100 microM), while either alone caused only partial block of the effect. In the presence of PKA inhibitor peptide, the inhibitory effect of Ang II was unaffected by the PKC inhibitor Go 6976, which is selective for Ca2+-dependent isoforms of PKC, but was abolished by a selective peptide inhibitor of the translocation of the epsilon isoform of PKC. Our results indicate that KATP channels are activated by steady-state phosphorylation by PKA at normal intracellular ATP levels, and that Ang II inhibits the channels both through activation of PKCepsilon and inhibition of PKA. (キーワード) Adenosine Triphosphate / Angiotensin II / Angiotensin II Type 1 Receptor Blockers / Angiotensin II Type 2 Receptor Blockers / Angiotensin Receptor Antagonists / Animals / Arteries / Cyclic AMP-Dependent Protein Kinases / Drug Combinations / Electric Conductivity / Enzyme Activation / Enzyme Inhibitors / Homeostasis / Isoenzymes / Male / Patch-Clamp Techniques / Potassium Channel Blockers / Potassium Channels / Protein Kinase C / Protein Kinase C-epsilon / Rats / Rats, Wistar / Receptor, Angiotensin, Type 1 / Receptor, Angiotensin, Type 2 / Receptors, Angiotensin (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1469-7793.2001.0193l.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11208968 ● Search Scopus @ Elsevier (PMID): 11208968 ● Search Scopus @ Elsevier (DOI): 10.1111/j.1469-7793.2001.0193l.x (DOI: 10.1111/j.1469-7793.2001.0193l.x, PubMed: 11208968)
93.	CL Lawrence, P Proks, GC Rodridgo, P Jones, Yasunobu Hayabuchi, NB Standen and FM. Ashcroft : Gliclazide produces high-affinity block of KATP channels in mouse isolated pancreatic beta cells but not rat heart or arterial smooth muscle cells., Diabetologia, Vol.44, No.8, 1019-1025, 2001. (要約) Sulphonylureas stimulate insulin secretion by closing ATP-sensitive potassium (KATP) channels in the pancreatic beta-cell membrane. KATP channels are also found in other tissues, including heart and smooth muscle, where they link cellular metabolism to electrical activity. The sulphonylurea gliclazide blocks recombinant beta-cell KATP channels (Kir6.2/SUR1) but not heart (Kir6.2/SUR2A) or smooth muscle (Kir6.2/SUR2B) KATP channels with high potency. In this study, we examined the specificity of gliclazide for the native (as opposed to recombinant) KATP channels in beta cells, heart and smooth muscle. The action of the drug was studied by whole-cell current recordings of native KATP channels in isolated pancreatic beta-cells and myocytes from heart and smooth muscle. Gliclazide blocked whole-cell beta-cell KATP currents with an IC50 of 184 +/- 30 nmol/l (n = 6-10) but was much less effective in cardiac and smooth muscle (IC50s of 19.5 +/- 5.4 micromol/l (n = 6-12) and 37.9 +/- 1.0 micromol/l (n = 5-10), respectively). In all three tissues, the action of the drug on whole-cell KATP currents was rapidly reversible. In inside-out patches on beta-cells, gliclazide (1 micromol/l) produced a maximum of 66 +/- 13 % inhibition (n = 5), compared with more than 98 % block in the whole-cell configuration. Gliclazide is a high-potency sulphonylurea which shows specificity for the pancreatic beta-cell KATP channel over heart and smooth muscle. In this respect, it differs from glibenclamide. The difference in the maximal block observed in the excised patch and whole-cell recordings from beta-cells, may be due to the absence of intracellular Mg-nucleotides in the excised patch experiments. (キーワード) Animals / Electric Conductivity / Gliclazide / Heart / Islets of Langerhans / Male / Mice / Muscle, Smooth, Vascular / Potassium Channel Blockers / Potassium Channels / Potassium Channels, Inwardly Rectifying / Rats / Rats, Wistar (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s001250100595 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11484080 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034883322 (DOI: 10.1007/s001250100595, PubMed: 11484080, Elsevier: Scopus)
94.	Kazuhiro Mori, Manabe Tetsuya, Nii Masaki, Yasunobu Hayabuchi, Yasuhiro Kuroda and Tatara Katsuyoshi : Myocardial integrated ultrasound backscatter in patients with Duchenne's progressive muscular dystrophy., Heart, Vol.86, No.3, 341-342, 2001. (キーワード) Adolescent / Cardiomyopathies / Humans / Muscular Dystrophy, Duchenne / Ultrasonography (出版サイトへのリンク) ● Publication site (DOI): 10.1136/heart.86.3.341a (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11514494 ● Summary page in Scopus @ Elsevier: 2-s2.0-0034874489 (DOI: 10.1136/heart.86.3.341a, PubMed: 11514494, Elsevier: Scopus)
95.	山本聖子, 早渕康信, 森一博, 黒田𣳾弘 : 稀な左上大静脈走行異常の2例, 小児科臨床, Vol.54, No.6, 967-970, 2001年.
96.	Kazuhiro Mori, Yasunobu Hayabuchi, Yasuhiro Kuroda, Masaki Nii and Tetsuya Manabe : Left ventricular wall motion velocities in healthy children measured by pulsed wave Doppler tissue echocardiography: normal values and relation to age and heart rate, Journal of the American Society of Echocardiography, Vol.13, No.11, 1002-1011, 2000. (要約) Left ventricular wall motion velocities were measured by pulsed wave Doppler tissue (PWDT) echocardiography in 131 healthy children (mean age 7.5 +/- 5.5 years) at the interventricular septum and the posterior wall in the left ventricular short-axis view, and at the interventricular septum and the lateral wall in the 4-chamber view. The systolic wave (Sw) consisted of 2 components, and the difference between the 2 components was greater in the lateral wall than in the other walls. The peak early diastolic wave (Ew) velocity was also highest in the lateral wall. Most variables during systole correlated with age. The ratio of peak atrial systolic wave (Aw) velocity to peak Ew velocity (Aw/Ew) correlated with heart rate. The Aw/Ew in each wall correlated with the ratio of late (A) to early (E) peak mitral flow, although regression slopes differed among different wall segments. In younger children with increased heart rates, the Aw/Ew ratio increased because the Ew velocity decreased, although the A/E ratio increased because of an increased A velocity. Normal values for the PWDT variables change with heart rate and age in the pediatric population. The data reported in this study can be used as normal values for left ventricular function for PWDT echocardiography. (キーワード) Adolescent / Adult / Age Factors / Blood Flow Velocity / Child / Child, Preschool / Diastole / Echocardiography, Doppler, Pulsed / Female / Heart Rate / Humans / Infant / Male / Mitral Valve / Myocardial Contraction / Systole / Ventricular Function, Left (出版サイトへのリンク) ● Publication site (DOI): 10.1067/mje.2000.108131 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 11093102 ● Summary page in Scopus @ Elsevier: 2-s2.0-0033653889 (DOI: 10.1067/mje.2000.108131, PubMed: 11093102, Elsevier: Scopus)
97.	Kazuhiro Mori, Tetsuya Manabe, Masaki Nii, Yasunobu Hayabuchi, Yasuhiro Kuroda and Hiroshi Kitahata : Cyclic variation of integrated ultrasound backscatter in the left ventricle during the early neonatal period., American Heart Journal, Vol.140, No.3, 463-468, 2000. (要約) Significant changes in the contractility and histologic structure of the ventricular myocardium occur during the early neonatal period. Cyclic variation (CV) of ultrasonic integrated backscatter (IBS) reflects myocardial contractile performance. The aim of this study was to define normal values of and its serial changes in CV of IBS in the left ventricle of normal neonates. We recorded long-axis IBS images in 169 healthy neonates within 14 days after birth (mean 4.6 +/- 4.2 days) and in 84 infants and children (mean age 8.7 +/- 5.2 years). For each, we obtained CV of IBS in the interventricular septum (CV(IVS)) and the posterior wall (CV(PW)). In neonates, there was a significant linear correlation between CV and date after birth in measurements of both the interventricular septum and the posterior wall (r = 0.57 and 0. 60, respectively). In infants and children, there was no significant relation between age and CV(IVS) or CV(PW). In neonates >4 days after birth, the magnitude of CV(IVS) was not significantly different from that in infants or children. By contrast, the magnitude of CV(PW) was still significantly decreased in neonates >9 days after birth compared with that in infants and children (P <. 005). The ratio of CV(IVS) to CV(PW) (CV(IVS)/CV(PW)) was significantly higher in neonates than in infants and children (0.99 +/- 0.29 vs 0.80 +/- 0.22, P <.001). Both CV(IVS) and CV(PW) in neonates gradually increase after birth, indicating developmental maturation of the left ventricle. High values of CV(IVS)/CV(PW) might reflect the remnant of relatively high contractile performance in the right ventricle during fetal life. (キーワード) Adolescent / Child / Child, Preschool / Echocardiography / Female / Heart Ventricles / Humans / Infant, Newborn / Male / Myocardial Contraction / Reference Values / Ventricular Function / Ventricular Function, Left (出版サイトへのリンク) ● Publication site (DOI): 10.1067/mhj.2000.108515 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10966549 ● Search Scopus @ Elsevier (PMID): 10966549 ● Search Scopus @ Elsevier (DOI): 10.1067/mhj.2000.108515 (DOI: 10.1067/mhj.2000.108515, PubMed: 10966549)
98.	Kazuhiro Mori, Yasunobu Hayabuchi, Yasuhiro Kuroda, Nii Masaki, Yuasa Yasuhiro and Taguchi Yoshiyuki : Retrograge holodiastolic flow in the abdominal aorta detected by pulsed Doppler echocardiography in patients with Kawasaki disease, European Journal of Pediatrics, Vol.159, No.7, 509-514, 2000. (要約) Retrograde holodiastolic flow in the abdominal aorta (retrograde flow) detected by pulsed Doppler echocardiography is usually noted in patients with aortic regurgitation or patent ductus arteriosus. Similar abnormal flow often is present in patients with acute phase Kawasaki Disease (KD). In 21 patients with acute phase KD, 15 had a retrograde flow. Retrograde flow was recognised in only 3 of patients with acute infection (n = 31) and in no healthy controls (n = 10). The ratio of the time velocity integral for diastolic retrograde flow to that for antegrade flow (regurgitant fraction) was significantly greater in patients with KD (median value 23%) than in patients with acute infection (1%) or healthy individuals (1%) (P < 0.001 for both). Four patients with coronary arterial involvement (one with an aneurysm and three with transient dilation of the coronary arteries) had a greater regurgitant fraction than the 17 patients without coronary arterial involvement (median values: 31% versus 18%, P < 0.05). The C-reactive protein was increased for a longer period of time in patients with KD with a greater regurgitant fraction (P < 0.01). Plasma nitric oxide (NO) metabolite concentrations were significantly greater in patients with KD than in those with acute infection or in healthy controls (P < 0.001 for both). There was a positive correlation between plasma NO metabolite concentrations and the regurgitant fraction in patients with KD (r = 0.69). Retrograde flow in the abdominal aorta is increased in patients with Kawasaki disease. Further studies are needed to clarify the causal relationship between the abnormal flow and the overproduction of nitric oxide. (キーワード) Aorta, Abdominal / Blood Flow Velocity / Child / Child, Preschool / Diastole / Echocardiography, Doppler, Pulsed / Female / Humans / Infant / Male / Mucocutaneous Lymph Node Syndrome / Nitric Oxide (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10923225 ● Search Scopus @ Elsevier (PMID): 10923225 (PubMed: 10923225)
99.	Kazuhiro Mori, Yasunobu Hayabuchi and Yasuhiro Kuroda : Diagnosis and natural history of isolated congenital pulmonary regurgitation in fetal life, Cardiology in the Young, Vol.10, No.2, 162-165, 2000. (要約) We describe a rare instance of isolated pulmonary regurgitation caused by a dysplastic pulmonary valve which was detected prenatally. Fetal echocardiography demonstrated severe pulmonary regurgitation, and progressive cardiomegaly because of right ventricular volume overload. After birth, conservative therapy was successful in alleviating the pulmonary vascular resistance, and the pulmonary regurgitation gradually decreased. (キーワード) Adult / Cardiomyopathy, Hypertrophic / Echocardiography, Doppler, Color / Female / Fetal Heart / Humans / Infant, Newborn / Pregnancy / Pulmonary Valve Insufficiency / Ultrasonography, Prenatal (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10817305 ● Search Scopus @ Elsevier (PMID): 10817305 (PubMed: 10817305)
100.	水井佐和, 早渕康信, 森一博, 真鍋哲也, 多田羅勝義, 若槻哲三, 黒田𣳾弘 : 冠動脈攣縮性狭心症による胸痛を来たした無脾症候群の1例, 小児科臨床, Vol.53, No.1, 37-40, 2000年.
101.	Yasunobu Hayabuchi, Suguru Matsuoka and Yasuhiro Kuroda : Plasma concentrations of atrial and brain natriuretic peptides and cyclic guanosine monophosphate in response to dobutamine infusion in patients with surgically repaired tetralogy of fallot, Pediatric Cardiology, Vol.20, No.5, 343-350, 1999. (要約) We examined the plasma concentrations of atrial and brain natriuretic peptides (ANP and BNP) and cyclic guanosine monophosphate (cGMP) during dobutamine infusion and their relationship with hemodynamic parameters in 14 patients with surgically repaired tetralogy of Fallot (TOF). Dobutamine was infused at an initial dose of 5 microgram/kg/min and increased by 5 microgram/kg/min up to 20 microgram/kg/min. The plasma ANP, BNP, and cGMP concentrations were determined before infusion, at the end of each stage, and 15 minutes after discontinuing dobutamine infusion. The plasma concentrations of ANP, BNP, and cGMP were elevated in all patients before dobutamine infusion. The ANP, BNP, and cGMP concentrations decreased in 11 of the 14 patients during dobutamine infusion. In contrast, the plasma ANP and BNP concentrations increased in the remaining 3 patients without a change in the cGMP concentration. The right ventricular pressure and volume were significantly elevated in these patients. The plasma cGMP concentration correlated with the ANP concentration (r = 0.62, p < 0.01) but not the BNP concentration. The plasma ANP concentration during dobutamine infusion correlated with right ventricular systolic pressure (r = 0.71, p < 0.05), mean right atrial pressure (r = 0.29, p < 0.05), and mean pulmonary capillary wedge pressure (r = 0.32, p < 0.05). The BNP concentration correlated with right ventricular volume (r = 0.61, p < 0.05) and systolic pressure (r = 0. 46, p < 0.05). In conclusion, rapid changes in ANP, BNP, and cGMP concentrations during dobutamine infusion reflect the changes in atrial and ventricle pressure and volume overload. In surgically repaired TOF, the ANP concentration is affected by right ventricular systolic pressure, right atrial pressure, and pulmonary capillary pressure. Furthermore, the BNP concentration reflects right ventricular pressure and volume overload. (キーワード) Adrenergic beta-Agonists / Atrial Natriuretic Factor / 血圧 (blood pressure) / Cardiac Catheterization / Cardiac Volume / Cardiotonic Agents / Case-Control Studies / Child, Preschool / Cyclic GMP / Dobutamine / Drug Monitoring / Humans / Infusions, Intravenous / Natriuretic Peptide, Brain / Pulmonary Wedge Pressure / Systole / Tetralogy of Fallot / Ventricular Pressure (出版サイトへのリンク) ● Publication site (DOI): 10.1007/s002469900481 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10441688 ● Search Scopus @ Elsevier (PMID): 10441688 ● Search Scopus @ Elsevier (DOI): 10.1007/s002469900481 (DOI: 10.1007/s002469900481, PubMed: 10441688)
102.	Kazuhiro Mori, Yasunobu Hayabuchi, Yasuhiro Kuroda, Yutaka Nakaya, Koichiro Tsuchiya and Hiroyuki Morimoto : Age-related endothelium-dependent vascular relazation in rat thoracic aorta in response to colforsin, Pediatrics International, Vol.41, No.6, 673-681, 1999. (要約) Colforsin, a novel water-soluble forskolin derivative, increases intracellular cyclic AMP by direct stimulation of adenylate cyclase and has strong positive inotropic and vasodilative effects. However, it is not known whether colforsin causes nitric oxide (NO) release and enhances endothelium-dependent vascular relaxation. We studied NO production and relaxation on exposure to colforsin in thoracic aorta from rats aged 4, 12 and 60 weeks. When a low concentration of colforsin was added to a solution bathing ring segments of aorta from 12-week-old rats, relaxation was greater in the ring segments with intact endothelium than in those from which the endothelium had been removed. A high concentration of colforsin induced the same degree of relaxation of ring segments with or without endothelium, probably by a direct effect on vascular smooth muscle cells. Production of NO in response to colforsin by cultured endothelial cells from 12-week-old rat aorta was demonstrated by the electron paramagnetic resonance spin trapping method. A low concentration of colforsin relaxed aortic segments with intact endothelium from 4-week-old rats more than those from 12-week-old or 60-week-old rats. Reversal of relaxation by NG-nitro L-arginine, an NO synthesis inhibitor, was most significant in arteries from 4-week-old rats. Production of NO after exposure to colforsin was greater in aortic segments from 4-week-old rats than older rats, as detected by an NO-selective electrode. Colforsin induces vasodilation in part by releasing NO from the endothelium in rat thoracic aorta. In addition to a direct vasodilative effect on the vascular smooth muscle cells, an endothelium-dependent vasodilative effect is also important in younger arteries. (キーワード) Aging / Animals / Aorta, Thoracic / Dose-Response Relationship, Drug / Electron Spin Resonance Spectroscopy / Endothelium, Vascular / Forskolin / Male / 一酸化窒素 (nitric oxide) / Rats / Rats, Wistar / Vasodilation / Vasodilator Agents (出版サイトへのリンク) ● Publication site (DOI): 10.1046/j.1442-200x.1999.01138.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 10618889 ● CiNii @ 国立情報学研究所 (CRID): 1570009749819091584 ● Search Scopus @ Elsevier (PMID): 10618889 ● Search Scopus @ Elsevier (DOI): 10.1046/j.1442-200x.1999.01138.x (DOI: 10.1046/j.1442-200x.1999.01138.x, PubMed: 10618889, CiNii: 1570009749819091584)
103.	Yasunobu Hayabuchi, Suguru Matsuoka, Masahiro Kubo and Yasuhiro Kuroda : Usefulness of color kinesis imaging for evaluation of regional right ventricular wall motion in patients with surgically repaired tetralogy of Fallot., The American Journal of Cardiology, Vol.82, No.10, 1224-1229, 1998.
104.	Yasunobu Hayabuchi, Yutaka Nakaya, Suguru Matsuoka and Yasuhiro Kuroda : Endothelium-derived hyperpolarizing factor activates Ca²⁺activated K⁺channels in porcine coronary artery smooth muscle cells, Journal of Cardiovascular Pharmacology, Vol.32, No.4, 642-649, 1998. (要約) Although endothelium-derived hyperpolarizing factor (EDHF) activity has been demonstrated in arteries from various species, EDHF has not been chemically identified, nor its mechanism of action characterized. To elucidate this mechanism, we tested the effect of EDHF on large-conductance Ca2+-activated K+ (K(Ca)) channels in porcine coronary artery smooth muscle cells. By using a patch-clamp technique, single-channel currents were recorded in cultured smooth muscle cells; the organ bath also contained a strip of porcine coronary with endothelium, which served as the source of endothelium-derived relaxing factor(s) including EDHF. Exposure of endothelium to 10(-6) M bradykinin activated K(Ca) channels in cultured smooth muscle cells in cell-attached patches. When the experiment was performed in the presence of 10 microM indomethacin and 30 microM N(G)-nitro-L-arginine (L-NNA), which block the generation of prostaglandin I2 (PGI2) and NO, respectively, K(Ca) channel activity was stimulated by bradykinin, indicating the direct involvement of EDHF in K(Ca) channel stimulation. Neither 10 microM methylene blue nor 25 microM Rp-cAMPS inhibited bradykinin-induced K(Ca) channel activity. In inside-out patches, the addition of bradykinin to the solution was without effect on K(Ca) channel activation. However, in the presence of 0.5 mM guanosine triphosphate (GTP) and 1.0 mM adenosine triphosphate (ATP) in the bath solution, K(Ca) channels was activated by bradykinin. In outside-out patches, the addition of bradykinin also increased K(Ca) channel activity, when GTP and ATP were added to the pipette solution. The addition of GDP-beta-S (100 microM) in the cytosolic solution completely blocked the activation K(Ca) channels induced by bradykinin in inside-out and outside-out patches. Pretreatment with 30 microM quinacrine, a phospholipase A2 inhibitor, or 3 microM 17-octadecynoic acid (17-ODYA), a cytochrome P450 inhibitor, in addition to indomethacin and L-NNA, abolished bradykinin-stimulated K(Ca) channel activity in cell-attached patches. Both 14,15-epoxyeicosatrienoic acid (EET) and 11,12-EET increased the open probabilities of K(Ca) channels in cell-attached patches. These results suggest that EDHF, released from endothelial cells in response to bradykinin, hyperpolarizes smooth muscle cells by opening K(Ca) channels. Furthermore, our data suggest that EDHF is an endothelium-derived cytochrome P450 metabolite of arachidonic acid. The effect of EDHF on K(Ca) channels is not associated with an increase of cAMP and cGMP. The activation of K(Ca) channels appears to be due to the activation of GTP-binding protein. (キーワード) Adenosine Triphosphate / Animals / Biological Factors / Bradykinin / Calcium / Cells, Cultured / Coronary Vessels / Cyclooxygenase Inhibitors / Drug Interactions / Enzyme Inhibitors / Indomethacin / Methylene Blue / Muscle, Smooth, Vascular / Patch-Clamp Techniques / Potassium Channels / Swine (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9781934 ● Search Scopus @ Elsevier (PMID): 9781934 (PubMed: 9781934)
105.	Yasunobu Hayabuchi, Yutaka Nakaya, Matsuoka Suguru and Yasuhiro Kuroda : Effect of acidosis on Ca²⁺-activatecd K⁺ channels in cultured porcine coronary artery smooth muscle cells, Pflügers Archiv : European Journal of Physiology, Vol.436, 509-514, 1998.
106.	Ito K, Matsumura T, Egawa Y, Watanabe M, Ohta A, Yasunobu Hayabuchi and Seki K : Primary mitral valve sarcoma in infancy, Pediatirc Cardiology, Vol.19, No.2, 174-177, 1998.
107.	Kazuhiro Mori, Yutaka Nakaya, Yasunobu Hayabuchi, Sakamoto Sadaichi, Matsuoka Suguru and Yasuhiro Kuroda : Lactate-induced vascular relaxation in porcine coronary arteries is mediated by Ca²⁺activated K⁺ channels, Journal of Molecular and Cellular Cardiology, Vol.30, No.2, 349-356, 1998. (要約) Under ischemic conditions and during strenuous exercise, lactate concentrations increase in coronary artery smooth muscle cells. Although lactate causes pH-independent vasorelaxation, the mechanisms responsible for this effect are unclear. We investigated the effect of lactate on K+ channels in smooth muscle cells from porcine coronary arteries. Neutralized lactate (3-100 mm) induced vasorelaxation in ring segments of porcine coronary arteries precontracted with KCl in a dose-dependent manner. One millimolar tetraethylammonium (TEA), an inhibitor of Ca2+-activated K+ channels (KCa channels), reversed the lactate-induced relaxation, while 60 microM glibenclamide, an inhibitor of ATP-sensitive K+ channels (KATP channels), did not. In both inside-out and cell-attached patch clamp technique with cultured smooth muscle cells, the KCa channels were activated by lactate. In inside-out patches, lactate activated KCa channels, even under acidic conditions. This is in contrast to the effect of H+ which inactivated KCa channels. We conclude that vasodilation of porcine coronary arteries induced by lactate is, at least in part, mediated by activation of KCa channels. This effect may be self-protective by maintaining coronary blood flow during ischemia. (キーワード) Animals / カルシウム (calcium) / Coronary Vessels / Hydrogen-Ion Concentration / Hypoxia / In Vitro Techniques / Lactic Acid / Muscle, Smooth, Vascular / 心筋虚血 (myocardial ischemia) / Patch-Clamp Techniques / Potassium Channels / Swine / Vasodilation (出版サイトへのリンク) ● Publication site (DOI): 10.1006/jmcc.1997.0598 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 9515011 ● Summary page in Scopus @ Elsevier: 2-s2.0-0032005001 (DOI: 10.1006/jmcc.1997.0598, PubMed: 9515011, Elsevier: Scopus)
108.	Yasunobu Hayabuchi, Yutaka Nakaya, Suguru Matsuoka and Yasuhiro Kuroda : Hydrogen peroxide-induced vascular relaxtion in porcine coronary arteries is mediated by Ca²⁺-activated K⁺ channels, Heart and Vessels, Vol.13, 9-17, 1998.
109.	早渕康信, 牛田美幸, 里村茂子, 大田明, 古川正強 : パルスオキシメーターの容積脈波を用いた末梢循環評価に関する研究, --- 第2編末梢循環不全評価の臨床的有用性に関する検討 ---, 日本小児科学会雑誌, Vol.100, No.11, 1724-1728, 1996年.
110.	早渕康信, 牛田美幸, 里村茂子, 大田明, 古川正強 : パルスオキシメーターの容積脈波を用いた末梢循環評価に関する研究, --- 第1編健康児の容積脈波伝達時間に影響を与える因子に関する検討 ---, 日本小児科学会雑誌, Vol.100, No.11, 1718-1723, 1996年.
111.	早渕康信, 大田明, 古川正強 : β遮断薬が奏効したアントラサイクリン系抗腫瘍剤に起因すると思われた心筋症の1例, 日本小児科学会雑誌, Vol.100, No.9, 1539-1544, 1996年.
112.	松岡優, 多田羅勝義, 早渕康信, 森田哲生, 井形高明 : 運動負荷中の心肺機能からみた運動処方, 臨床スポーツ医学, Vol.13, No.1, 81-86, 1996年.
113.	Kazuhiro Mori, matsuoka Suguru, Yasunobu Hayabuchi, Yasuhiro Kuroda and Tetsuya Kitagawa : Absence of the inferior vena cava in a patient with omphalocele: tow-dimensional echocardiographic and cineangiographic findings, Heart and vessels, Vol.11, No.2, 104-109, 1996.
114.	Yasunobu Hayabuchi, Suguru Matsuoka, Masahiro Kubo, Kazuhiro Mori, Katsunori Tatara and Yasuhiro Kuroda : Usefulness of QRST isointegral maps for the diagnosis of right ventricular pressure overload in patients with surgically repaired tetralogy of Fallot complicated with right bundle branch block, Journal of Electrocardiology, Vol.29, No.2, 111-117, 1996. (要約) Right ventricular pressure overload was evaluated in 29 patients, 8-12 years old, with surgically repaired tetralogy of Fallot by using body surface QRST isointegral maps. In patients with right ventricular systolic pressure above 50 mmHg, the maxima of the isointegral maps tended to shift toward the lower right-hand region of the map. The maximum value was significantly correlated with right ventricular systolic pressure (r = .58; P < .01). There was a correlation between the right ventricular systolic pressure and the percentage +2SD and percentage +5SD departure areas, which are defined as the area (expressed as a percentage of the total chest area) in which the QRST integral values are greater than the normal mean +2SD or +5SD, respectively (r = .61 and .84, P < .01). The QRST isointegral map can be used to evaluate right ventricular pressure overload in postoperative patients with tetralogy of Fallot complicated by right bundle branch block. The percentage +5SD departure area is the most valuable parameter for the quantitative evaluation of the right ventricular systolic pressure. (キーワード) Body Surface Potential Mapping / Bundle-Branch Block / Case-Control Studies / Child / Humans / Postoperative Complications / Signal Processing, Computer-Assisted / Tetralogy of Fallot / Ventricular Dysfunction, Right / Ventricular Pressure (出版サイトへのリンク) ● Publication site (DOI): 10.1016/S0022-0736(96)80120-8 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8728596 ● Summary page in Scopus @ Elsevier: 2-s2.0-0029942801 (DOI: 10.1016/S0022-0736(96)80120-8, PubMed: 8728596, Elsevier: Scopus)
115.	新居正基, 松岡優, 森一博, 早渕康信, 真鍋哲也, 黒田𣳾弘, 坂東重信, 西角彰良, 山本克人 : 高周波カテーテルアブレーションが奏効した潜在性WPW症候群の1例, 小児科臨床, Vol.48, No.10, 2339-2342, 1995年.
116.	松岡優, 森一博, 早渕康信, 多田羅勝義, 湯浅安人, 黒田𣳾弘 : 輸血後C型肝炎の慢性期における血清学，ウイルス学および組織学的検討, 小児科臨床, Vol.48, No.6, 1197-1201, 1995年.
117.	森一博, 松岡優, 早渕康信, 黒田𣳾弘, 中屋豊 : 摘出ラット大動脈に対するアムリノンの内皮依存性血管弛緩作用と加齢による影響, 日本小児循環器学会雑誌, Vol.11, No.4, 536-544, 1995年.
118.	森一博, 松岡優, 早渕康信, 黒田𣳾弘, 中屋豊, 土屋浩一郎 : 摘出ブタ大動脈でのアムリノンによる一酸化窒素(NO)産生の測定, 日本小児循環器学会雑誌, Vol.11, No.4, 545-550, 1995年.
119.	早渕康信, 松岡優 : QRST isointegral mapによる先天性心疾患開心術後心室頻拍発生の予測に関する検討, 日本小児科学会雑誌, Vol.99, No.5, 977-983, 1995年.
120.	早渕康信, 松岡優, 後口ユリ, 新居正基, 久保雅宏, 森一博, 多田羅勝義, 黒田𣳾弘 : 乳児期早期のFallot四徴症におけるballoon pulmonary valvuloplasty の有用性に関する検討, 心臓, Vol.27, No.4, 300-305, 1995年.
121.	EE Antouniou, Matsuoka Suguru, Kazuhiro Mori, Yasunobu Hayabuchi and Yasuhiro Kuroda : Anomalous inferiorvena cava in association with omphalocele: a case report, Pediatric Radiology, Vol.25, No.4, 265-266, 1995. (要約) We present the case of a 6-year-old boy who had an omphalocele repaired at day 1 of life. He had a secundum atrial septal defect and an anomalous inferior vena cava of a type which has not been previously reported. Cine-MRI was a useful noninvasive tool for diagnosing the anomalous subaortic innominate vein and four immature vessels which make up the venous drainage systems of the lumbar region. The recognition of this malformation is important in planning and executing surgical repair or cardiac catheterization for postoperative patients with omphaloceles. (キーワード) 子ども (children) / Heart Septal Defects, Atrial / Hernia, Umbilical / Humans / Magnetic Resonance Imaging, Cine / Male / Vena Cava, Inferior (出版サイトへのリンク) ● Publication site (DOI): 10.1007/BF02011095 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7567232 ● Search Scopus @ Elsevier (PMID): 7567232 ● Search Scopus @ Elsevier (DOI): 10.1007/BF02011095 (DOI: 10.1007/BF02011095, PubMed: 7567232)
122.	Kazuhiro Mori, Matsuoka Suguru, Tatara Katusnori, Yasunobu Hayabuchi, Nii Masaki and Yasuhiro Kuroda : Echoicardiographic evaluation of the development of aortic valve prolapse in supracristal ventricular septal defect, European Journal of Pediatrics, Vol.154, No.3, 176-181, 1995.
123.	Matsuoka Suguru, EE Antoniou, Kazuhiro Mori, Yasunobu Hayabuchi and Yasuhiro Kuroda : The first report of a patient with interrupted inferior vena cava, multiple post-renal veins and azygos-hemiazygos continuation, Acta Pediatrica Japonica, Vol.37, No.4, 514-517, 1995.
124.	早渕康信, 大田明, 古川正強, 江川善康, 松村長生 : 左室に原発したintimal sarcomaの1乳児例, 日本小児循環器学会雑誌, Vol.11, No.4, 568-576, 1995年.
125.	早渕康信, 大田明, 古川正強, 江川善康, 増田裕, 松村長生 : 心エコー図による左房コンプライアンス評価の試み, 日本小児循環器学会雑誌, Vol.11, No.6, 754-762, 1995年.
126.	早渕康信, 松岡優, 久保雅宏, 秋田裕司, 黒田𣳾弘 : Signal-averaged ECG (SA-ECG)に対する人工ペースメーカーの影響の検討, 心臓, Vol.26, No.6, 74-76, 1994年.
127.	早渕康信, 松岡優, 久保雅弘, 秋田裕司, 黒田𣳾弘 : Signal-averaged ECG (SA-ECG)に対する人工ペースメーカーの影響の検討, 心臓, Vol.26, No.6, 74-77, 1994年.
128.	多田羅勝義, 松岡優, 早渕康信, 久保雅弘, 後口ユリ, 黒田𣳾弘 : ファロー四徴症術後患者における運動負荷時呼吸パターンの検討, 日本小児循環器学会雑誌, Vol.9, No.5, 631-638, 1994年.
129.	新居正基, 松岡優, 森一博, 早渕康信, 多田羅勝義, 黒田𣳾弘 : 大動脈弓下無名静脈走行異常の6例 DSA, MRI, 心エコー所見, 日本小児循環器学会雑誌, Vol.10, No.4, 533-538, 1994年.
130.	早渕康信, 松岡優, 秋田裕司, 久保雅宏, 田口義行, 黒田𣳾弘 : 先天性心疾患開心術後患児における体表面加算平均心電図, --- 高速フーリエ変換を用いた異常高周波数成分の検出 ---, 心臓, Vol.26, No.8, 809-817, 1994年.
131.	Matsuoka Suguru, Tatara Katsunori, Yasunobu Hayabuchi, Taguchi Yoshiyuki, Kazuhiro Mori, Hirohito Honda, Susumu Ito, Yuasa Yasuto and Yasuhiro Kuroda : Serologic, virologic, and histologic characteristics of chronic phase hepatitis C virus disease in children infected by transfusion, Pediatrics, Vol.94, No.6, 919-922, 1994.
132.	Matsuoka Suguru, Tatara Katsunorii, Yasunobu Hayabuchi, Nii Masaki, Kazuhiro Mori and Yasuhiro Kuroda : Post-transfusion chronic hepatitis in children, Journal of Paediatrics and Child Health, Vol.30, No.6, 544-546, 1994. (要約) Two hundred and twenty-six patients who received blood products for open-heart surgery in childhood were screened by a second-generation enzyme-linked immunosorbent assay and with surrogate markers for hepatitis C virus (HCV) infection, such as alanine aminotransferase (ALT). Twenty-two (14%) of the 161 recipients who received blood products before 1989 and none of the subjects who had received blood products after 1990 (the year that the blood bank began to screen for HCV antibody) were HCV seropositive. Virologic and histologic studies showed that 10 (45%) of 24 seropositive patients had persistent hepatitis C virus infection, many with ongoing hepatitis. The remaining 12 seropositive patients with absent HCV RNA had normal ALT levels, indicating resolved hepatitis C infection. Enrolment in screening is important to detect chronic hepatitis C in children who received blood products prior to screening of blood donors for HCV antibody. (キーワード) Acute Disease / Adolescent / Child / Child, Preschool / Chronic Disease / Enzyme-Linked Immunosorbent Assay / Female / Follow-Up Studies / Hepacivirus / Hepatitis Antibodies / Hepatitis C / Humans / Male / Mass Screening / RNA, Viral / Transfusion Reaction (出版サイトへのリンク) ● Publication site (DOI): 10.1111/j.1440-1754.1994.tb00731.x (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7865272 ● Summary page in Scopus @ Elsevier: 2-s2.0-0027942412 (DOI: 10.1111/j.1440-1754.1994.tb00731.x, PubMed: 7865272, Elsevier: Scopus)
133.	早渕康信, 松岡優 : 完全房室ブロック患者における体表面加算平均心電図に関する研究, 日本小児科学会雑誌, Vol.98, No.6, 1169-1175, 1994年.
134.	早渕康信, 松岡優, 多田羅勝義, 森田哲生, 岩瀬毅信, 井形高明, 黒田𣳾弘 : サッカー選手に対する多角的メディカルチェック, 臨床スポーツ医学, Vol.11, No.6, 686-690, 1994年.
135.	森一博, 松岡優, 多田羅勝義, 早渕康信, 新居正基, 黒田𣳾弘 : 進行性筋ジストロフィー症における肺静脈血流分析, 日本小児循環器学会雑誌, Vol.10, No.2, 248-256, 1994年.
136.	早渕康信, 松岡優, 久保雅宏, 秋田裕司, 森一博, 多田羅勝義, 黒田𣳾弘 : 右脚ブロックを有するファロー四徴症心内修復術後患者の右室圧負荷評価におけるQRST isointegral mapの有用性に関する検討, 日本小児循環器学会雑誌, Vol.10, No.4, 508-515, 1994年.
137.	Yasunobu Hayabuchi, Suguru Matsuoka, Y Takahashi, Hiroshi Akita, Tetsuya Kitagawa, Itsuo Kato and Yasuhiro Kuroda : Hyperuricemia in an infant with Taussig-Bing anomaly and interruption of the aortic arch, Pediatric Cardiology, Vol.15, No.5, 249-251, 1994. (要約) Hyperuricemia is commonly recognized in adolescents and adults with cyanotic congenital heart disease. We report a case of a male infant with hyperuricemia, Taussig-Bing anomaly, and interruption of the aortic arch. The patient underwent correction of interrupted aortic arch and pulmonary arterial banding at the age of 7 days. Hyperuricemia appeared when he was 2 months old (max 17.7 mg/dl) and persisted until he underwent a Jatene operation at the age of 10 months. The hyperuricemia improved gradually after the disappearance of hypoxia and polycythemia. The laboratory findings suggest that hyperuricemia can result from uric acid overproduction due to secondary polycythemia, impairment of uric acid excretion by the kidney, or the acceleration of anaerobic metabolism. Allopurinol and benzbromarone together were partially effective treatments for hyperuricemia in this patient with cyanotic congenital heart disease. (キーワード) Abnormalities, Multiple / Aorta / Heart Defects, Congenital / Heart Septal Defects, Ventricular / Humans / Infant, Newborn / Male / Polycythemia / Transposition of Great Vessels / Uric Acid (出版サイトへのリンク) ● Publication site (DOI): 10.1007/BF00795737 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 7997431 ● Search Scopus @ Elsevier (PMID): 7997431 ● Search Scopus @ Elsevier (DOI): 10.1007/BF00795737 (DOI: 10.1007/BF00795737, PubMed: 7997431)
138.	秋田裕司, 後口ユリ, 松岡優, 久保雅弘, 早渕康信, 多田羅勝義, 黒田𣳾弘 : 運動負荷時における体表面加算平均心電図検査の有用性と限界について, 小児科診療, Vol.57, No.3, 462-466, 1994年.
139.	Yasunobu Hayabuchi, Suguru Matsuoka, Masahiro Kubo, Hiroshi Akita and Yasuhiro Kuroda : Singnal-averaged electrocardiographic late potentials in children with complete heart block, Clinical Cardiology, Vol.17, 325-329, 1994.
140.	早渕康信, 松岡優, 久保雅宏, 森一博, 多田羅勝義, 黒田𣳾弘 : 体表面加算平均心電図によるWolff-Parkinson-White症候群における房室回帰性頻拍の予測に関する検討, 呼吸と循環, Vol.42, No.11, 1073-1078, 1994年. (出版サイトへのリンク) ● Publication site (DOI): 10.11477/mf.1404900955 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.11477/mf.1404900955 (DOI: 10.11477/mf.1404900955)
141.	Yasunobu Hayabuchi, Suguru Matsuoka, Masahiro Kubo, Hiroshi Akita and Yasuhiro Kuroda : Age-related criteria for signal-averaged electrocardiographic late potentials in children, Pediatric Cardiology, Vol.15, No.3, 107-111, 1994. (要約) This study examined the age-related criteria of signal-averaged electrocardiographic (SA-ECG) parameters in children. SA-ECGs were obtained in 82 healthy volunteers in six groups depending on age (group 1: 1 day to < 1 month; group 2: 1 month to < 1 year; group 3: 1 to < 6 years; group 4: 6 to < 12 years; group 5: 12 to < 20 years; group 6: 20 to < 40 years). To examine the effect of heart rate on the parameters of SA-ECG, right atrial pacings were performed in 4 children with a ventricular septal defect aged 1-7 years. The root mean square voltage (RMS) was high; and the filtered QRS (f-QRS) duration and the duration of the low amplitude signal (LAS) were low during childhood, especially in infants (group 2), compared with those in adults. Late duration (LD) had no significant difference among age groups. The criteria for ventricular late potential were as follows: RMS < 25 microV, LAS > 35 ms, f-QRS duration > 110 ms, and LD > 35 ms for those age 1 day to < 1 month; RMS < 40 microV, LAS > 30 ms, f-QRS duration > 100 ms, and LD > 35 ms for those age 1 month to < 1 year; RMS < 20 microV, LAS > 40 ms, f-QRS duration > 130 ms, and LD > 35 ms for those age 1 to < 20 years; and RMS < 15 microV, LAS > 45 ms, f-QRS duration > 135 ms, and LD > 35 ms for those age 20 to < 40 years. RMS and LAS correlated with f-QRS duration (r = -0.78 and 0.76, respectively; p < 0.05), suggesting that these parameters are associated with the thickness of the ventricular muscle and the ventricular conduction time. Right atrial pacing had no effect on the measured SA-ECG parameters. The age-related differences in SA-ECG parameters might be due to age-related differences in the thickness of the ventricular muscle and the ventricular conduction time but are not due to differences in the heart rate. The age difference of each parameter on SA-ECG should be considered for ventricular late potentials. (キーワード) Adolescent / Adult / Age Factors / Arrhythmias, Cardiac / 子ども (children) / Child, Preschool / Electrocardiography / Heart Conduction System / Heart Rate / Heart Septal Defects, Ventricular / Heart Ventricles / Humans / 小児 (infant) / Infant, Newborn / Reference Values / Ventricular Function (出版サイトへのリンク) ● Publication site (DOI): 10.1007/BF00796320 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 8047490 ● Search Scopus @ Elsevier (PMID): 8047490 ● Search Scopus @ Elsevier (DOI): 10.1007/BF00796320 (DOI: 10.1007/BF00796320, PubMed: 8047490)
142.	Yasunobu Hayabuchi, Suguru Matsuoka, Masaki Nii, Hiroko Suzuya and Yasuhiro Kuroda : Cerebral infarction in a patient with congenital heart block, Clinical Cardiology, Vol.21, 302-303, 1994.
143.	久保雅弘, 松岡優, 多田羅勝義, 後口ユリ, 早渕康信, 新居正基, 大村博美, 黒田𣳾弘 : 加算平均心電図を利用したWPW症候群における早期脱分極電位の検討, 心臓, Vol.25, No.5, 20-26, 1993年.
144.	松岡優, 秋田裕司, 久保雅弘, 早渕康信, 田口義行, 北川哲也, 三木理, 加藤逸夫, 伊井邦雄, 黒田𣳾弘 : ファロー四徴症術後症例における平均加算心電図の研究:時間領域および周波数領域解析併用の有用性について, 日本小児循環器学会雑誌, Vol.8, No.5, 602-609, 1993年.
145.	久保雅弘, 松岡優, 早渕康信, 多田羅勝義, 松家豊, 黒田𣳾弘 : Duchenne型進行性筋ジストロフィー症における加算平均心電図の周波数解析, 呼吸と循環, Vol.41, No.11, 1073-1078, 1993年.
146.	Kubo Masahiro, Matsuoka Suguru, Yasunobu Hayabuchi, Akita Hiroshi and Yasuhiro Kuroda : Abnormal signal-averaged electrocardiogram in patients with Duchenne muscular dystrophy: Comparisonof time and frequency domain analyses from the signal-averaged electrogram, Clincal Cardiology, Vol.16, No.10, 723-728, 1993.
147.	Matsuoka Suguru, Akita Hiroshi, Yasunobu Hayabuchi, Taguchi Yoshiyuki, Kubo Masahiro, Tetsuya Kitagawa and Katoh Itsuo : Abnormal signal averaged ECG after surgical repair of tetralogy of Fallot - a combined analysis in time and frequency domain, Japanese Circulation Journal, Vol.57, No.9, 841-850, 1993.
148.	早渕康信, 松岡優, 高橋芳夫, 秋田裕司, 北川哲也, 加藤逸夫, 黒田𣳾弘 : 乳児期より著明な高尿酸血症を呈したTaussig-Bing奇形·大動脈弓離断の1例, 日本小児循環器学会雑誌, Vol.8, No.4, 576-580, 1993年.
149.	久保雅弘, 松岡優, 秋田裕司, 早渕康信, 松家豊, 黒田𣳾弘 : Duchenne型進行性筋ジストロフィー症における心室遅延電位の研究, --- 加算平均心電図の周波数領域および時間領域の解析 ---, 心臓, Vol.25, No.8, 900-906, 1993年.
150.	秋田裕司, 松岡優, 久保雅弘, 早渕康信, 黒田𣳾弘 : 先天性心疾患術後右脚ブロック患者における体表面加算平均心電図所見, 呼吸と循環, Vol.41, No.7, 641-645, 1993年.
151.	早渕康信, 松岡優, 秋田裕司, 黒田𣳾弘 : チアノーゼ性先天性心疾患における高尿酸血症の発症に関する検討, 日本小児科学会雑誌, Vol.97, No.7, 1572-1576, 1993年.
152.	Masahiro Kubo, Suguru Matsuoka, Yasunobu Hayabuchi, Hiroshi Akita, Yutaka Matsuka and Yasuhiro Kuroda : Abnormal signal-averaged electrocardiogram in patients with Duchenne muscular dystrophy: Comparison of time and frequency domain analyses from the signal-averaged electrocardiograms, Clincal Cardiology, Vol.16, No.5, 723-728, 1993.
153.	Hiroshi Akita, Suguru Matsuoka, Yoshiyuki Taguchi, Masahiro Kubo, Yasunobu Hayabuchi and Yasuhiro Kuroda : Abnormal findings in the signal-averaged electrocardiogram in patients with Ebstein's anomaly, Acta Paediatrica Japonica, Vol.35, No.4, 72-73, 1993.
154.	秋田裕司, 松岡優, 田口義行, 久保雅弘, 早渕康信, 黒田𣳾弘 : 右脚ブロックを有する先天性心疾患術後患者のにおける体表面加算平均心電図所見, 呼吸と循環, Vol.41, No.3, 237-241, 1993年.
155.	早渕康信, 松岡優, 黒田𣳾弘 : 不顕性リウマチ熱による弁膜症の診断·治療基準について, 小児科臨床, Vol.46, No.11, 2637-2640, 1993年.
156.	早渕康信, 松岡優 : 小児における体表面加算平均心電図による心室遅延電位の判定基準に関する研究, 日本小児科学会雑誌, Vol.97, No.3, 761-766, 1993年.
157.	Yasunobu Hayabuchi, Suguru Matsuoka, Hiroshi Akita and Yasuhiro Kuroda : Hyperuricaemia in cyanotic congenital heart disease, European Journal of Pediatrics, Vol.152, 873-876, 1993.
158.	秋田裕司, 松岡優, 久保雅弘, 早渕康信, 黒田𣳾弘 : 先天性心疾患術後右脚ブロックの部位診断におけるsignal-averaged ECGの有用性, 心臓, Vol.24, No.4, 12-16, 1992年.
159.	秋田裕司, 松岡優, 田口義行, 久保雅弘, 早渕康信, 黒田𣳾弘 : Ebstein奇形における体表面加算平均心電図の異常所見について, 呼吸と循環, Vol.40, No.10, 993-997, 1992年.
160.	秋田裕司, 松岡優, 早渕康信, 高橋芳夫, 黒田𣳾弘, 北川哲也, 脇坂佳成, 滝浩樹, 三木理, 加藤逸夫, 江川善康 : 遠位型大動脈肺動脈中隔欠損の1新生児例, 心臓, Vol.24, No.6, 690-694, 1992年.
161.	早渕康信, 松岡優, 高橋芳夫, 秋田裕司, 黒田𣳾弘 : 心筋炎による多臓器不全を呈した1治験例, 小児科臨床, Vol.45, No.5, 1063-1069, 1992年.
162.	早渕康信, 武田英二, 伊藤道徳, 西條隆彦, 内藤悦雄, 松田純子, マーブブルホク, 黒田𣳾弘 : 関節痛により発見されたマンノシドーシスの姉妹例, 日本小児科学会雑誌, Vol.95, No.7, 1666-1671, 1991年.
163.	Suguru Matsuoka, Hiroshi Akita, Yoshio Takahashi, Atsuko Nishioka, Yasunobu Hayabuchi and Yasuhiro Kuroda : Assessment of sinus node function in patients with congenital long QT syndrome, Japanese Circulation Journal, Vol.55, No.5, 487-489, 1991.

学術論文(紀要・その他):

1.	前田潤, 古谷喜幸, 稲井慶, 小穴慎二, 梶野浩樹, 上砂光裕, 松裏裕行, 松岡瑠美子, 森克彦, 須田憲治, 飯島正紀, 池原聡, 大木寛生, 金丸浩, 田内宣生, 中島弘道, 西原栄起, 濱岡建城, 早渕康信, 堀米仁志, 桃井伸緒, 安田謙二, 横澤正人, 新垣義夫, 市田蕗子, 小野安生, 小山耕太郎, 黒江兼司, 小林俊樹, 城尾邦隆, 白石公, 中川雅生, 野村裕一, 総崎直樹, 村上智明, 安河内聰, 安田東始哲, 中西敏雄, 山岸敬幸 : チアノーゼ性先天性心疾患における脳膿瘍の疫学, 日本小児循環器学会雑誌, Vol.29, No.5, 236-242, 2013年. (出版サイトへのリンク) ● Publication site (DOI): 10.9794/jspccs.29.236 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9794/jspccs.29.236 (DOI: 10.9794/jspccs.29.236)
2.	上砂光裕, 新垣義夫, 市田蕗子, 小穴慎二, 小川潔, 小野安生, 小山耕太郞, 黒江兼司, 小林俊樹, 城尾邦隆, 白石公, 中川雅生, 中島弘道, 野村裕一, 早渕康信, 総崎直樹, 古谷喜幸, 古野憲司, 前田潤, 松裏裕行, 松岡留美子, 村上智明, 森克彦, 安河内聰, 安田謙二, 安田東始哲, 山岸敬幸, 藁谷理, 中西敏雄 : Williams症候群の表現型-心疾患およびその他年齢別に注意すべき症状の頻度, --- 平成17∼19年度研究課題報告 ---, 日本小児循環器学会雑誌, Vol.25, No.2, 224-226, 2009年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571698600677176832 (CiNii: 1571698600677176832)
3.	中島多恵, 前田潤, 山岸敬幸, 新垣義夫, 大木寛生, 市田蕗子, 小穴慎二, 小川潔, 小野安生, 上砂光裕, 高永煥, 小山耕太郞, 梶野浩樹, 黒江兼司, 小林俊樹, 城尾邦隆, 白石公, 瀧聞浄宏, 竹田津未生, 中川雅生, 中島弘道, 野村裕一, 早渕康信, 総崎直樹, 古谷喜幸, 古野憲司, 松裏裕行, 松岡留美子, 村上智明, 森克彦, 安河内聰, 安田謙二, 安田東始哲, 与田仁志, 藁谷理, 中西敏雄 : 無脾症，多脾症における重症感染症の疫学, --- 平成17∼19年度研究課題報告 ---, 日本小児循環器学会雑誌, Vol.25, No.2, 221-223, 2009年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1573668925514146688 (CiNii: 1573668925514146688)
4.	前田潤, 山岸敬幸, 新垣義夫, 大木寛生, 市田蕗子, 小穴慎二, 小川潔, 小野安生, 上砂光裕, 高永煥, 小山耕太郞, 梶野浩樹, 黒江兼司, 小林俊樹, 城尾邦隆, 白石公, 瀧聞浄宏, 竹田津未生, 中川雅生, 中島弘道, 野村裕一, 早渕康信, 総崎直樹, 古谷喜幸, 古野憲司, 松裏裕行, 松岡留美子, 村上智明, 森克彦, 安河内聰, 安田謙二, 安田東始哲, 与田仁志, 藁谷理, 中西敏雄 : 18および13トリソミーの心表現型・遺伝子型と予後, --- 平成17∼19年度研究課題報告 ---, 日本小児循環器学会雑誌, Vol.25, No.2, 216-220, 2009年. (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1571417125700114048 (CiNii: 1571417125700114048)
5.	森一博, 松岡優, 早渕康信, 香美祥二 : 右位心・中位心, 日本臨牀, Vol.7, No.7, 33-36, 2008年.
6.	森一博, 松岡優, 早渕康信, 香美祥二 : 収縮期雑音心室中隔欠損大動脈弁下狭窄, 症状と所見から考える心血管エコー, 163-167, 2008年.

学術レター:

1.	阪田美穂, 早渕康信, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 進行性に3枝ブロックを認め，ペースメーカー治療を要した新生児例, 第18回日本小児心電学会, 2013年.

総説・解説:

1.	早渕康信 : Heart-Driven, 日本小児循環器学会雑誌, Vol.39, No.4, 169-170, 2023年12月.
2.	早渕康信 : 心室拡張障害の病態と診断, 日本小児循環器学会雑誌, Vol.39, No.3, 116-125, 2023年12月.
3.	早渕康信 : 川崎病 - 急性期および慢性期診療 -, 日本小児科医会会報, Vol.64, No.1, 18-20, 2022年12月. (キーワード) 川崎病 / MIS-C / コロナ感染症
4.	早渕康信 : 右心不全の病態生理と機能評価, 日本小児循環器学会雑誌, Vol.27, No.4, 295-306, 2021年12月. (キーワード) 右室 / 右心不全 / 肺高血圧 / 右室-肺動脈カップリング (徳島大学機関リポジトリ) ● Metadata: 118044 (出版サイトへのリンク) ● Publication site (DOI): 10.9794/jspccs.37.295 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1390856207410856448 ● Search Scopus @ Elsevier (DOI): 10.9794/jspccs.37.295 (徳島大学機関リポジトリ: 118044, DOI: 10.9794/jspccs.37.295, CiNii: 1390856207410856448)
5.	早渕康信 : 肺循環障害と右心不全の病態と治療 -小児心臓病のパラダイムシフト-, 四国医学雑誌, Vol.76, No.5, 6, 251-258, 2020年12月. (要約) Potassium channels play diverse roles in regulating the behavior of pulmonary artery smooth muscle cells. The discovery of KCNK3(TASK1)as a new predisposing gene for pulmonary arterial hypertension(PAH)led to an update in the Nice Classification regarding the genetic origin of PAH. Decreased current via KCNA5(Kv1．5)plays a key role in determining pulmonary arterial tone and vascular remodeling. The transformation of smooth muscle cells causes ion channel switching, such as the loss of BKca(Kca1．1)and the gain of IKca(Kca3．1), in immature proliferative smooth muscle cells and also induces cell migration, proliferation, and apoptosis resistance. We propose OCT as a useful tool in diagnosing pulmonary artery hypertension and may provide helpful information for the pulmonary arterial remodeling process, severity, therapeutic strategy, and prognosis in congenital heart disease. (キーワード) pulmonary artery / potassium channel / pulmonary hypertension / optical coherence tomography / vasa vasorum (徳島大学機関リポジトリ) ● Metadata: 115783 (文献検索サイトへのリンク) ● CiNii @ 国立情報学研究所 (CRID): 1050005888447563008 (徳島大学機関リポジトリ: 115783, CiNii: 1050005888447563008)
6.	Yasunobu Hayabuchi : Right Ventricular Myocardial Stiffness and Relaxation Components by Kinematic Model-Based Analysis, The Journal of Medical Investigation : JMI, Vol.67, No.1.2, 11-20, Feb. 2020. (要約) Right ventricle (RV) has frequently been described as the forgotten ventricle in the circulation. However, its importance in various cardiac diseases is now unquestioned. This recognition has led to improved risk stratification and development of algorithms for intervention, which incorporate measurements of RV function as key components of the assessment of many conditions. The diastolic function plays an important role in determining ventricular filling and stroke volume. Abnormal left ventricular (LV) diastolic function has been recognized in many cardiovascular diseases and is associated with worse outcomes, including total mortality and hospitalizations due to heart failure. In this review, we define what global RV diastolic function is, and how to measure it. This article indicates the validation of kinematic model parameters for assessing RV diastolic function. J. Med. Invest. 67 : 11-20, February, 2020. (キーワード) right ventricle / diastolic function / stiffness / relaxation / pressure phase plane (徳島大学機関リポジトリ) ● Metadata: 114745 (出版サイトへのリンク) ● Publication site (DOI): 10.2152/jmi.67.11 (文献検索サイトへのリンク) ● PubMed @ National Institutes of Health, US National Library of Medicine (PMID): 32378593 ● Search Scopus @ Elsevier (PMID): 32378593 ● Search Scopus @ Elsevier (DOI): 10.2152/jmi.67.11 (徳島大学機関リポジトリ: 114745, DOI: 10.2152/jmi.67.11, PubMed: 32378593)
7.	早渕康信 : 総説「肺高血圧症の病態と新規治療をカリウムチャネル制御から探る」日本小児循環器学会雑誌」, 日本小児循環器学会雑誌, Vol.32, No.3, 189-198, 2016年5月. (要約) 肺動脈平滑筋細胞に存在するカリウムチャネルは多彩な種類と機能を有し，多くの生理作用ならびに病態に関与している．肺動脈性肺高血圧症(PAH)においても発症と増悪に深く関与していることが明らかになりつつある．2013年にtwo-pore domainカリウムチャネルの1種であるKCNK3(TASK1)の遺伝子変異がPAHの原因遺伝子であると証明され，第5回肺高血圧国際シンポジウム(ニース国際会議)で追加された．また，PAHでは発症原因にかかわらず，電位依存性カリウムチャネル，特にKCNA5(Kv1.5)の発現低下と活性抑制が認められ，肺動脈収縮と血管リモデリングを促進することが示されている．さらに，平滑筋細胞に認められるカルシウム活性化カリウムチャネルは，形質転換によってBKca(Kca1.1)からIKca(Kca3.1)優位に変化し，平滑筋細胞の遊走の促進，増殖能の亢進，アポトーシスの抑制などに影響を与えている．これら肺血管の収縮とリモデリングへのカリウムチャネルの役割を解明することで，新たな治療戦略が見えてくるものと期待される． (キーワード) カリウムチャネル (potassium channel) / Pulmonary arterial hypertension / smooth muscle cell (徳島大学機関リポジトリ) ● Metadata: 113946 (出版サイトへのリンク) ● Publication site (DOI): 10.9794/jspccs.32.189 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.9794/jspccs.32.189 (徳島大学機関リポジトリ: 113946, DOI: 10.9794/jspccs.32.189)
8.	石井亜由美, 西川幸治, 伊勢孝之, 門田宗之, 八木秀介, 岩瀬俊, 木下肇, 阪田美穂, 早渕康信, 北川哲也, 赤池雅史, 加藤真介, 佐田政隆 : 単心室症患児の開心術後にフェイススケールを用いて心臓リハビリテーションを試みた1症例, 心臓, Vol.48, No.2, 181-186, 2016年2月. (キーワード) 心臓リハビリテーション / 小児 (infant) / フェイススケール
9.	早渕康信 : 第109回医師国家試験問題解説, 第109回医師国家試験問題解説, 2015年4月.
10.	Yasunobu Hayabuchi, Miho Sakata and Shoji Kagami : Multidetector Row Computed Tomography Evaluation in Pediatric Heart Diseases -Additional Information to Echocardiography and Conventional Cardiac Catherterization, International Journal of Pediatric Research, Vol.1, No.1, 1, Feb. 2015.
11.	早渕康信 : Editorial Comment 一酸化窒素吸入療法とPhosphodiesterase-5 阻害薬による肺高血圧および心不全治療の可能性, 日本小児循環器学会雑誌, Vol.30, No.1, 36-38, 2014年1月.
12.	早渕康信 : 低酸素換気療法と神経発達障害評価のこれから, 日本小児循環器学会雑誌, Vol.26, No.5, 413-415, 2010年10月.
13.	Yasunobu Hayabuchi, Miki Inoue, Miho Sakata and Shoji Kagami : Multidector-Row Computed Tomography Evaluation in Congenital Heart Disease Patients - Additional Information to Echocardiology and Conventional Cardiac Characterization, Congenital Heart Defects: Etiology, Diagnosis and Treatment, 209-229, Dec. 2009.
14.	森一博, 早渕康信, 香美祥二, 山田博胤 : 2Dティッシュトラッキング法の小児科領域への応用, Medix, Vol.46, 19-23, 2007年.

国際会議:

1.	Shimamoto Keiko, Ohno Seiko, Sonoda Keiko, Morita Hiroshi, Goto Hiroko, Mukai Yasushi, Matsuo Kensuke, Miyoshi Miwa, Yoshida Shuichiro, Noma Takahisa, Watanabe Shigeo, Yoshida Yoko, Fukunaga Hideo, Kajiyama Yo, Yasunobu Hayabuchi, Nagashima Michio, Ogawa Yoshiharu, Muneuchi Jun, Tanaka Masamichi, Sakaguchi Heima, Kato Yoshiaki, Oka Satoshi, Wakamiya Akinori, Miyazaki Yuichiro, Nakajima Kenzaburo, Ueda Nobuhiko, Kamakura Tsukasa, Wada Mitsuru, ishibashi kohei, Inoue Yuko, Miyamoto Koji, Nagase Satoshi, Asano Yoshihiro, Sumitomo Naokata, Horie Minoru, Kusano F. Kengo and Aiba Takeshi : Long-term Prognosis of Patients with Catecholaminergic Polymorphic Ventricular Tachycardia in Japan, Heart Rhythm, New Orleans, May 2023. (出版サイトへのリンク) ● Publication site (DOI): 10.1016/j.hrthm.2023.03.515 (文献検索サイトへのリンク) ● Search Scopus @ Elsevier (DOI): 10.1016/j.hrthm.2023.03.515 (DOI: 10.1016/j.hrthm.2023.03.515)
2.	Yasunobu Hayabuchi : KSE-JSE Joint Symposium, The role of echocardiography in neuromuscular disease : Recent advances in the treatment and echocardiography for cardiac disorder in children with neuromuscular diseases., KSE-JSE Joint Symposium in The 30th annual scientific meeting of the Japanese society of Echocardiography, Matsumoto, May 2019.
3.	Yasunobu Hayabuchi : Optical Coherence Tomography: Evaluation of Pulmonary Circulation, 15th Korea Japan China Pediatric Heart Forum, Seoul, Apr. 2019.
4.	Takashi Kaji, Yasunobu Hayabuchi, Kazuhisa Maeda, Atsuko Hichijyo, Naoto Yonetani, Takahashi Yohei, Nakayama Soichiro and Minoru Irahara : Prenatal assessment of coronary artery anatomy using color Doppler in cases of D-transposition of the great arteries: case reports., Prenatal assessment of coronary artery anatomy using color Doppler in cases of D-transposition of the great arteries: case reports., Rome, Sep. 2016.
5.	Takashi Kitaichi, Mikio Sugano, Eiki Fujimoto, Tamotsu Kanbara, Hajime Kinoshita, Taisuke Nakayama, Miho Sakata, Yasunobu Hayabuchi and Tetsuya Kitagawa : PERMANENT EPICARDIAL PACING INPEDIATRIC PATIENTS, ASCVTS2013, Apr. 2013.
6.	Hirotsugu Kurobe, takashi Tominaga, Masahisa Urata, Mikio Sugano, Yoichiro Hirata, Miho Sakata, Yasunobu Hayabuchi, Takashi Kitaichi, Takaki Hori, Yoshiyasu Egawa, Yousuke Takahama and Tetsuya Kitagawa : Complete thymectomy during cardiac surgery in early infancy reduces circulating T cells and vaccination-induced IgG responses: a study of 3-year-tracing, AATS2012 92th annual meeting, San Francisco, Apr. 2012.
7.	Yasunobu Hayabuchi, Miki Inoue, Noriko Watanabe, Miho Sakata and Shoji Kagami : Serum concentration of heart-type fatty acid-binding protein in children and adolescents with congenital heart disease, The 3rd Congress of Asia-Pacific Pediatric Cardiac Society, Chiba, Jul. 2010.
8.	Nabo Mohamed Helmy Manal, Yasunobu Hayabuchi, Miki Inoue, Noriko Watanabe, Miho Sakata and Shoji Kagami : Assessmentof modified Blalock-Taussig shunt in children with congenital heart disease using multidetector-row computed tomography, 5th China-Korea-Japan Pediatric Heart Forum, Beijing, Sep. 2009.
9.	Yasunobu Hayabuchi, Miki Inoue, Miho Sakata, Tetsuya Kitagawa, Takashi Kitaichi and Shoji Kagami : Assessment of systemic-pulmonary collateral arteries in children with cyanotic congenital heart disease using multidetector-row computed tomography: Comparison with conventional angiography, 5th World Congress of Paediatric Cardiology and Cardiac Surgery, Cairns, Jun. 2009.
10.	Takashi Kitaichi, Homare Yoshida, M Urata, Tatsuo Motoki, Hirotsugu Kurobe, Tamotsu Kanbara, Yasunobu Hayabuchi and Tetsuya Kitagawa : A simple patch technique of VSD with the progression of aortic cusp prolapsed or less than mild aortic regurgitasion, 5th World Congress of Paediatric Cardiology and Cardiac Surgery, オーストラリア, Jun. 2009.
11.	Kazuhiro Mori, Nii Masaki, Manabe Tetsuya, Yasunobu Hayabuchi and Yasuhiro Kuroda : Myocardial integrated backscatter in patients with Duchenne's progressive muscular dystrophy, The 3rd World Congress of Pediatric Cardiology and Cardiac Surgery, Tronto, Canada, Mar. 2001.
12.	Jones P., Proks P., Lawrence C., Yasunobu Hayabuchi, Rodrigo G., Standen N.B. and Ascroft M. F. : Gliclazide produces high affinity block of KATP channels in mouse isolated pancreatic beta-cells but not rat heart or smooth muscle cells, The Physiological Society Meeting, Oxford, UK, Mar. 2001.
13.	Yasunobu Hayabuchi, Davies N.W. and Standen B. N. : Angioatensin II inhibits KATP channels of isolated arterial smooth muscle cells through protein kinase A and C, The Physiological Society of Physiology, Cambridge, Jul. 2000.
14.	Yasunobu Hayabuchi, Standen N.B. and Davies N.W. : Angiotensin II inhibits and alters the kinetics of deyaled reftifieer channels of arterial smooth muscle cells, The Physiology Society Meeting, Cambridge, Jul. 2000.
15.	Yasunobu Hayabuchi : Angiotensin II inhibits and alters teh kinetics of delayed rectifier channels of arterial smooth muscle cells, The Physiology Society Meeting, Cambridge, Jul. 2000.
16.	Nii Masaki, Yuasa Yasuto, Kazuhiro Mori, Matsuoka Suguru, Yasunobu Hayabuchi and Yasuhiro Kuroda : Elevation of ventricular wall motion in postoperative patients with tetralogy of Fallot using intramyocardial pulsed Doppler echocardiography, 10th Congress of the International Cardiac Doppler Society, Takamatsu, Nov. 1998.
17.	Kazuhiro Mori, Yasunobu Hayabuchi, Yasuhiro Kuroda and Nii Masaki : Retrograde holodiastolic flow in the abdominal aorta detected by pulsed Doppler echocardiography in patients with Kawasaki disease- Its relation to plasma nitric oxide levels, 10th Congress of the International Cardiac Doppler Society, Takamatsu, Nov. 1998.
18.	Yasunobu Hayabuchi, Matsuoka Suguru, Tatara Katsunori, Nii Masaki and Yasuhiro Kuroda : The kinetics of the plasma levels of atrial and brain natriuretic peptide, and cyclic guanosine monophosphate to the dobutamine in surgically repaired tetralogy of Fallot, The 2nd World Congress of pediatric cardiology and cardiac surgery, Hawaii, USA, May 1997.
19.	Nii Masaki, Yasunobu Hayabuchi, Matsuoka Suguru and Yasuhiro Kuroda : Power spectrum analysis of heart rate variability in preterm infants, --- Relationship between apnea of prematuriry and autonomic function ---, The 2nd World Congress of Pediatric Cardiology and Cardiac Surgery, Hawaii, USA, May 1997.
20.	Yasunobu Hayabuchi, Matsuoka Suguru, Kazuhiro Mori and Yasuhiro Kuroda : Usefulness of QRST isointegral maps for the diagnosis of right ventricular pressure overload in patients with surgically reparied tetralogy of Fallot, 23rd International Congress on Electrocardiology, Cleveland, USA, Jul. 1996.
21.	Yasunobu Hayabuchi, Matsuoka Suguru, Kubo Masahiro, Kazuhiro Mori and Yasuhiro Kuroda : Signal averaged electrocardiograms in surgically repaired congenital heart disease patients, --- Fast Fourier Transform analysis ---, The 3rd international Congress of Heart Failure, Geneve, Switzerland, May 1995.
22.	Yasunobu Hayabuchi, Matsuoka Suguru, Akita Hiroshi, Kubo Masahiro, Kazuhiro Mori and Yasuhiro Kuroda : Fast Fourier Transform analysis of signal averaged electocardiograms in surgically repaired congenital heart disease patients, 12th World Congress of Cardiology, Berlin, Sep. 1994.

国内講演発表:

1.	本間友佳子, 早渕康信, 菅野幹雄, 北市隆, 秦広樹 : 乳児特発性僧帽弁腱索断裂を併発した三尖弁閉鎖症の1例, 第38回日本小児循環器学会近畿・中四国地方会, 2024年3月.
2.	本間友佳子, 早渕康信 : B-T shunt閉塞とカテーテル治療による再開通を4年間に2回を繰り返した単心室症例, 第34回JCIC学術集会, 2024年1月.
3.	本間友佳子, 早渕康信 : Fontan術後に肝細胞癌を発症し加療を要した2例, 第25回日本成人先天性心疾患学会総会・学術集会, 2024年1月.
4.	本間友佳子, 早渕康信 : 心臓移植施設への搬送を2回試みたが，ともに始動段階で叶わなかった拡張型心筋症の1例, 第160回日本小児科学会徳島地方会, 2023年12月.
5.	本間友佳子, 早渕康信 : 洞不全のためペースメーカー植え込みを施行したが，運動時意識消失発作を繰り返した拘束型心筋症, 第27回日本小児心電学会学術集会, 2023年12月.
6.	本間友佳子, 早渕康信 : ファロー四徴症術後症例における右室-肺動脈カップリング(Ees/Ea)のSurrogate指標としてのRVFAC/TRPGの有用性, 第32回日本小児心筋疾患学会・第42回日本小児循環動態研究会合同学術集会, 2023年10月.
7.	本間友佳子, 早渕康信 : FLNC と MYH6のヘテロ接合体のミスセンス変異を有し，意識消失発作を繰り返した拘束型心筋症の1例, 第32回日本小児心筋疾患学会・第42回日本小児循環動態研究会合同学術集会, 2023年10月.
8.	早渕康信 : 術後遠隔期および成人期の心室中隔欠損症の心エコー, 日本心エコー図学会第20回秋期講習会, 2023年10月.
9.	森西啓介, 林昌晃, 野田康裕, 玉上大暉, 平良竣也, 近田優介, 本間友佳子, 早渕康信 : 当院における心臓移植施設への搬送に伴う車両と機器選定の検討, 第32回徳島小児循環器談話会, 2023年9月.
10.	加地剛, 中川奉宇, 吉田あつ子, 白河綾, 峯田あゆか, 菅野幹雄, 早渕康信, 岩佐武 : ポスタ-発表胎児2 手術を要した単独VSDの胎児診断および出生後診断についての検討, 第59回日本小児循環器学会総会·学術集会, 2023年7月.
11.	本間友佳子, 早渕康信, 菅野幹雄, 北市隆, 秦広樹 : ポスタ-発表画像診断1 ファロー四徴症術後症例における右室-肺動脈カップリング(Ees/Ea)のSurrogate指標としてのRVFAC/TRPGの有用性, 第59回日本小児循環器学会総会·学術集会, 2023年7月.
12.	早渕康信 : シンポジウム「肺高血圧を伴う先天性心疾患への肺血管拡張療法」 Fontan術後症例における肺血管拡張剤, 第59回日本小児循環器学会総会・学術集会, 2023年7月.
13.	本間友佳子, 早渕康信, 菅野幹雄, 北市隆, 秦広樹 : ファロー四徴症術後症例における右室-肺動脈カップリング(Ees/Ea)のSurrogate指標としてのRVFAC/TRPGの有用性, 第59回日本小児循環器学会総会・学術集会, 2023年7月.
14.	早渕康信, 本間友佳子 : 心室圧波形のみから得られる心室駆出率 ―単心室・複雑な心室形態の患者における有用性の検討―, 第59回日本小児循環器学会総会・学術集会, 2023年7月.
15.	武井美貴子, 木下ゆき子, 岸揚子, 小野朱美, 森一博, 本間友佳子, 早渕康信, 漆原真樹 : 不完全型重複大動脈弓の1例:新生児エコースクリーニングの有用性, 第159回日本小児科学会徳島地方会, 2023年6月.
16.	本間友佳子, 早渕康信, 漆原真樹, 菅野幹雄, 北市隆, 秦広樹 : 乳児特発性僧帽弁腱索断裂を併発した三尖弁閉鎖閉鎖症の1例, 第159回日本小児科学会徳島地方会, 2023年6月.
17.	早渕康信 : シンポジウム「小児循環器学会学術誌の充実へ向けて」学術雑誌の査読プロセスと注意点, 第59回日本小児循環器学会総会・学術集会, 2023年4月.
18.	早渕康信 : パネルディスカッション「先天性心疾患における右室拡張能評価」ファロー四徴症術後症例における心エコー検査を用いた右室拡張能評価の有用性と限界, 第34回日本心エコー図学会学術集会, 2023年4月.
19.	本間友佳子, 早渕康信 : ファロー四徴症術後症例における右室-肺動脈カップリング(Ees/Ea)のSurrogate指標としてのRVFAC/TRPGの有用性, 第34回日本心エコー図学会学術集会, 2023年4月.
20.	早渕康信 : 教育セミナー「拡張能の評価 -拡張早期の心室弛緩能-」, 日本小児循環器学会学会第14回教育セミナー Advanced course, 2023年2月.
21.	本間友佳子, 早渕康信 : 動脈管開存症にコイル塞栓術を施行した後にコイル感染と動脈管瘤をきたした1例, 第33回日本先天性心疾患インターベンション学会学術集会, 2023年1月.
22.	本間友佳子, 早渕康信 : 心臓外の病態のために顕著な低酸素血症，生命的危急状態に陥った心室中隔欠損・Eisenmenger 症候群の2例, 第24回日本成人先天性心疾患学会総会・学術集会, 2023年1月.
23.	本間友佳子, 早渕康信 : FLNC と MYH6 のヘテロ接合体のミスセンス変異を有し，意識消失発作を繰り返した拘束型心筋症の1例, 第158回日本小児科学会徳島地方会, 2022年12月.
24.	早渕康信 : フォンタン手術とは何か?術後患児の生活と管理, 令和4年度第2回徳島県医師会認定学校医研修会, 2022年11月.
25.	早渕康信, 本間友佳子 : 圧波形解析による右室拡張能の評価 -Relaxation とElastic recoil の識別-, 第41回日本小児循環動態研究会・第31回日本小児心筋疾患学会合同学術集会, 2022年10月.
26.	早渕康信 : パネルディスカッション心エコー塾・成人先天性心疾患を極める!「房室中隔欠損症における超音波診断」, 第49回日本超音波医学会関西地方会学術集会, 2022年10月.
27.	本間友佳子, 早渕康信 : 動脈管開存症にコイル塞栓術を施行した後にコイル感染と動脈瘤をきたした1例, 第31回徳島小児循環器談話会, 2022年9月.
28.	加地剛, 早渕康信 : 左腕頭動脈孤立症・左鎖骨下動脈孤立症の胎児診断について, 第58回日本小児循環器学会総会・学術集会, 2022年7月.
29.	菅野幹雄, 木村優希, 本間友佳子, 佐村高明, 藤本鋭貴, 北市隆, 早渕康信, 秦広樹 : TCPC後に狭小VSDの拡大を要したTA2bの一例, 第58回日本小児循環器学会総会・学術集会, 2022年7月.
30.	早渕康信, 本間友佳子 : Bidirectional Glenn術後症例における肺動脈外膜vasa vasorum増生とFontan術後の短期・長期予後に関する検討, 第58回日本小児循環器学会総会・学術集会, 2022年7月.
31.	早渕康信, 本間友佳子 : 圧波形解析による右室拡張能のシミュレーション -RelaxationとElastic recoilの識別と可視化-, 第58回日本小児循環器学会総会・学術集会, 2022年7月.
32.	本間友佳子, 早渕康信 : ファロー四徴症術後症例の右室拡張能に対する左右心室機能および循環動態の影響, 第58回日本小児循環器学会総会・学術集会, 2022年7月.
33.	本間友佳子, 早渕康信 : 光干渉断層像 (Optical Coherence Tomography:OCT) を用いた肺動脈性肺高血圧症における肺動脈病変の評価, 第58回日本小児循環器学会総会・学術集会, 2022年7月.
34.	本間友佳子, 早渕康信 : 光干渉断層像(Optical Coherence Tomography:OCT)を用いた肺動脈性肺高血圧症における肺動脈病変の評価, 第7回日本肺高血圧・肺循環学会学術集会, 2022年7月.
35.	本間友佳子, 早渕康信, 菅野幹雄, 北市隆, 秦広樹 : 動脈管開存症にコイル塞栓術を施行した後にコイル感染と動脈瘤を来した1例, 第117回日本小児科学会徳島地方会, 2022年6月.
36.	林優里, 早渕康信, 鈴江真史, 須賀健一, 中川竜二, 菅野幹雄, 北市隆, 秦広樹 : 周術期に心室頻拍(VT)・異所性節五部頻拍(JET)・異所性心房頻拍(EAT)が認められ，管理に難渋した完全大血管転換症の1例, 第117回日本小児科学会徳島地方会, 2022年6月.
37.	早渕康信 : 教育講演6「川崎病 -急性期および慢性期診療-」, 第33回日本小児科医会総会フォーラム, 2022年6月.
38.	本間友佳子, 早渕康信 : 動脈管開存症に肝血管腫を合併した新生児の下行大動脈の血流パターンについての考察, 第33回日本心エコー図学会学術集会, 2022年4月.
39.	本間友佳子, 早渕康信 : ファロー四徴症術後症例における右室拡張能評価はガイドラインのアルゴリズムを使用できない, 第33回日本心エコー図学会学術集会, 2022年4月.
40.	早渕康信 : パネルディスカッション知っておくべきACHDの心エコー「肺動脈弁輪運動速度を用いた右室機能評価」, 第33回日本心エコー図学会学術集会, 2022年4月.
41.	早渕康信 : 令和3年度徳島県学校心臓検診結果報告, 徳島県医師会学校保健委員会心臓検診対策班講演会, 2022年3月.
42.	菅野幹雄, 本間友佳子, 佐村高明, 藤本鋭貴, 北市隆, 早渕康信, 秦広樹 : 左上大静脈左房灌流に対して心房内reroutingを施行し，術後遠隔期に機能的僧帽弁狭窄を来した一例, 第36回日本小児循環器学会近畿・中四国地方会, 2022年3月.
43.	本間友佳子, 郷司彩, 森達夫, 早渕康信, 菅野幹雄, 北市隆, 秦広樹 : 憤怒痙攣が診断の契機となった完全大血管転位症術後における冠状動脈狭窄・心筋虚血の1乳児例, 第36回日本小児循環器学会近畿・中四国地方会, 2022年3月.
44.	本間友佳子, 早渕康信 : 緊急心臓カテーテル治療によって救命し得た単心室 (Fontan手術施行不可症例) の2例, 第32回 JCIC学会学術集会, 2022年1月.
45.	本間友佳子, 早渕康信, 飛梅威, 佐田政隆, 中島博, 相庭武司 : S-ICD植え込みを施行したQT延長症候群の5歳男児例, 第25回日本小児心電学会学術集会, 2021年11月.
46.	本間友佳子, 早渕康信 : BNPのわずかな上昇にもかかわらず，著明な心筋トロポニンIの上昇を来したマイコプラズマ心膜心筋炎の1例, 第30回日本小児心筋疾患学会学術集会, 2021年10月.
47.	早渕康信, 本間友佳子 : 無負荷時心筋最大短縮速度 (Vmax) ，生理的心筋最大短縮速度 (Vpm) による右室収縮能評価, 第57回日本小児循環器学会総会・学術集会, 2021年7月.
48.	本間友佳子, 早渕康信 : Fontan手術後患児におけるGH治療は蛋白漏出性胃腸症発症のリスク因子である, 第57回日本小児循環器学会総会・学術集会, 2021年7月.
49.	早渕康信, 本間友佳子 : パネルディスカッション「診断に役立つ心エコー検査の最前線」右室流入血流拡張早期波形(E波形)解析による右室拡張能に関わる因子 (Elastic recoil, Relaxation, Load)の評価, 第57回日本小児循環器学会総会・学術集会, 2021年7月.
50.	本間友佳子, 早渕康信 : パネルディスカッション「診断に役立つ心エコー検査の最前線」ファロー四徴症術後症例における右室拡張能評価はガイドラインのアルゴリズムを使用できない, 第57回日本小児循環器学会総会・学術集会, 2021年7月.
51.	早渕康信, 本間友佳子 : シンポジウム「シミュレーション医学による先天性心疾患の診断と治療」 Fontan循環症例における肺動脈および体静脈の血管形態に関する光干渉断層像(OCT画像)を用いた経時的観察による検討, 第57回日本小児循環器学会総会・学術集会, 2021年7月.
52.	本間友佳子, 早渕康信 : シンポジウム「シミュレーション医学による先天性心疾患の診断と治療」光干渉断層像(Optical Coherence Tomography:OCT)による画像描出・解像度の向上に関する検討, 第57回日本小児循環器学会総会・学術集会, 2021年7月.
53.	佐藤宏紀, 本間友佳子, 菅野幹雄, 北市隆, 郷司彩, 森達夫, 早渕康信 : 憤怒痙攣が診断の契機となった完全大血管転位術後における冠状動脈狭窄・心筋虚血の1乳児例, 第135回日本小児科学会徳島地方会, 2021年6月.
54.	福良翔子, 鈴江真史, 須賀健一, 本間友佳子, 早渕康信, 渡邊浩良, 中川竜二 : 重症一過性骨髄異常増殖症に対し，少量シタラビン療法を行った21トリソミーの1例, 第135回日本小児科学会徳島地方会, 2021年6月.
55.	早渕康信 : シンポジウム「学校検診で見つかる小児心疾患 -心エコーの役割-」学校心臓検診を契機に診断される小児期心筋症の診断とポイント, 第94回日本超音波医学会学術集会, 2021年5月.
56.	本間友佳子, 早渕康信 : 術後遠隔期の精査加療の必要性を再認識した総肺静脈還流異常3例, 第6回日本肺高血圧・肺循環学会学術集会, 2021年5月.
57.	早渕康信, 本間友佳子 : Fontan症例の肺動脈 vasa vasorum -3次元構築と経時的変化-, 第6回日本肺高血圧・肺循環学会学術集会, 2021年5月.
58.	本間友佳子, 早渕康信 : 前負荷増加による左室・右室の拡張期圧の変化は心エコー指標で予想可能である, 第32回日本心エコー図学会学術集会, 2021年4月.
59.	早渕康信 : 令和2年度徳島県心臓検診結果報告, 徳島県医師会学校保健委員会心臓検診対策班講演会, 2021年3月.
60.	本間友佳子, 早渕康信, 飛梅威, 佐田政隆, 中島博 : S-ICD植え込みを施行したQT延長症候群の5歳男児例, 第35回日本小児循環器学会近畿・中四国地方会, 2021年3月.
61.	早渕康信 : 両大血管右室起始症の心エコー検査, 第23回エコーウインターセミナー, 2021年2月.
62.	早渕康信 : 先天性心疾患の病態と肺高血圧症治療, 日本新薬株式会社勉強会, 2021年2月.
63.	本間友佳子, 早渕康信 : 緊急心臓カテーテル治療によって救命し得た単心室2症例, 第154回日本小児科学会徳島地方会, 2020年12月.
64.	本間友佳子, 早渕康信 : 著明な心筋トロポニンIの上昇を来したマイコプラズマ心膜心筋炎の1例, 第154回日本小児科学会徳島地方会, 2020年12月.
65.	本間友佳子, 早渕康信 : 光干渉断層像(Optical Coherence Tomography:OCT) による肺動脈・冠動脈病変の3次元画像評価, 第56回日本小児循環器学会総会・学術集会, 2020年11月.
66.	本間友佳子, 早渕康信 : ファロー四徴症術後症例における右室拡張能:心エコーによるドプラ解析と心臓カテーテル検査による圧解析の比較検討, 第56回日本小児循環器学会総会・学術集会, 2020年11月.
67.	加地剛, 祖川英至, 吉田あつ子, 米谷直人, 早渕康信, 苛原稔 : Dual Gate Dopplerを用いた肝静脈-下行大動脈血流波形による胎児不整脈評価の有用性と限界:当院での10年間の経験から, 第29回学術集会日本小児心筋疾患学会学術集会, 2020年11月.
68.	菅野幹雄, 本間友佳子, 藤本鋭貴, 北市隆, 早渕康信, 秦広樹 : 左上大静脈左房灌流に対する心房内rerouting後に機能的僧帽弁狭窄を来した一例, 第56回日本小児循環器学会総会・学術集会, 2020年11月.
69.	小野朱美, 森一博, 早渕康信 : Compound heterozygoteのため若年発症した重症不整脈原性右室心筋症の女児例および一家系, 第56回日本小児循環器学会総会・学術集会, 2020年11月.
70.	早渕康信, 本間友佳子 : 肺動脈におけるvasa vasorumの3次元画像構築 ― Fontan candidateにおける経時的変化と臨床的有用性-, 第56回日本小児循環器学会総会・学術集会, 2020年11月.
71.	早渕康信, 本間友佳子 : 右室圧から得られる新しい指標 RVωはTei index (MPI)を反映し，ファロー四徴症術後症例における右心不全を評価できる, 第56回日本小児循環器学会総会・学術集会, 2020年11月.
72.	小野朱美, 森一博, 早渕康信, 本間友佳子, 江見美杉, 上山敦子, 廣瀬将樹, 石井良, 石田秀和, 成田淳 : Compound heterozygoteのため若年発症した重症不整脈原性右室心筋症の女児例および一家系, 第29回日本小児心筋疾患学会学術集会, 2020年10月.
73.	本間友佳子, 早渕康信 : RYR2遺伝子のミスセンス変異を認めた左室心筋緻密化障害の1例, 第29回日本小児心筋疾患学会学術集会, 2020年10月.
74.	早渕康信 : シンポジウム「成人先天性心疾患と心エコー」ファロー四徴症手術後症例 -診断のポイントと管理-, 第31回日本心エコー図学会学術集会, 2020年8月.
75.	本間友佳子, 早渕康信 : ファロー四徴症術後症例における右室拡張能:心エコーによるドプラ解析と心臓カテーテル検査による圧解析の比較検討, 第31回日本心エコー図学会学術集会, 2020年8月.
76.	早渕康信 : 肺循環障害と右心不全の病態と治療 -小児心臓病のパラダイムシフト-, 第261回徳島医学会学術集会, 2020年8月.
77.	石井亜由美, 伊勢孝之, 西川幸治, 本間友佳子, 鈴木佳子, 大南博和, 門田宗之, 飛梅威, 八木秀介, 早渕康信, 加藤真介, 佐田政隆 : 心配停止をきたしQT延長症候群と診断されS-ICD植込みとなった5歳児に対する心リハの経験, 第26回日本心臓リハビリテーション学会学術集会, 2020年7月.
78.	石井亜由美, 伊勢孝之, 西川幸治, 本間友佳子, 鈴木佳子, 大南博和, 門田宗之, 八木秀介, 早渕康信, 加藤真介, 佐田政隆 : 小児に関する心臓リハビリテーションの取り組みと症例から学んだこと, 第26回日本心臓リハビリテーション学会学術集会, 2020年7月.
79.	前田崇彰, 加地剛, 早渕康信, 中川竜二, 祖川英至, 吉田あつ子, 米谷直人, 須賀健一, 稲村昇, 苛原稔 : 胎児診断により動脈管閉鎖に伴う血行動態変化を観察できた左腕頭動脈孤立症の1例, 第93回日本超音波医学会, 2020年5月.
80.	本間友佳子, 早渕康信, 杉本真弓, 須賀健一, 香美祥二, 井本逸勢 : 肺高血の進行を来した心房中隔欠損(小欠損孔) を伴う Inflammatory skin and bowel disease, neonatal, 1 (NISBD1) 疑いの一例, 第26回日本小児肺循環研究会, 2020年2月.
81.	本間友佳子, 早渕康信, 香美祥二 : 11年間に8回のコイル塞栓術を施行した両側肺全区域びまん性多発性肺動静脈瘻の1例, 第31回JPIC学術集会, 2020年1月.
82.	小野朱美, 森一博, 武井美貴子, 岡田朝美, 佐々木亜由美, 庄野実希, 木下ゆき子, 早渕康信, 大野聖子, 加藤浩一 : Compound heterozygote のため若年発症した重症不整脈原性右室心筋症の一例, 第153回日本小児科学会徳島地方会, 2019年12月.
83.	本間友佳子, 早渕康信, 中野睦基, 香美祥二, 飛梅威, 添木武, 佐田政隆, 佐々木亜由美, 木下ゆき子, 森一博, 中島博 : Bystander CPR からの救命の連鎖が奏効したQT延長症候群の1幼児例, 第153回日本小児科学会徳島地方会, 2019年12月.
84.	本間友佳子, 早渕康信, 香美祥二 : 幼児期から胸痛が認められた冠攣縮性狭心症の1例, 第153回日本小児科学会徳島地方会, 2019年12月.
85.	藤中ちひろ, 鈴江真史, 早渕康信 : 総肺静脈還流異常Ibの一新生児例:市中病院の超音波検査士の立場から, 第5回日本小児超音波研究会, 2019年11月.
86.	本間友佳子, 早渕康信, 香美祥二 : 両方向性グレン術後患者では肺動脈壁 vasa vasorum が増生する - Optical coherence tomography (OCT)による観察ー, 第71回中国四国小児科学会, 2019年11月.
87.	本間友佳子, 早渕康信, 香美祥二 : 診断に苦慮した胸痛の2例, 第15回四国小児循環器病研究会, 2019年10月.
88.	本間友佳子, 早渕康信, 香美祥二, 加地剛, 廣野恵一, 西田尚樹, 畑由紀子 : 心室中隔の菲薄化による心室瘤と心筋緻密化障害様の肉柱形成を呈した1例, 第28回日本小児心筋疾患学会学術集会, 2019年10月.
89.	早渕康信, 本間友佳子, 香美祥二 : 右室圧から得られる新しい指標 RVw = (dP/dt_max - dP/dt_min) / (Pmax - Pmin) は Tei index (MPI) に相当する global cardiac function を簡便に再現性高く評価できる, 第39回日本小児循環動態研究会学術集会, 2019年10月.
90.	本間友佳子, 早渕康信, 香美祥二, 加地剛, 苛原稔 : 胎児期に心室瘤の所見を呈した3例, 第30回徳島小児循環器談話会, 2019年9月.
91.	本間友佳子, 早渕康信, 香美祥二, 加地剛, 苛原稔 : 胎児期に心室瘤を疑わせる所見を呈した3例, 第37回中国四国地区小児循環器談話会, 2019年9月.
92.	早渕康信 : 肺循環と右心機能:病態生理とその評価法, 第11回肺循環フォーラム in 広島, 2019年9月.
93.	本間友佳子, 早渕康信, 杉本真弓, 須賀健一, 香美祥二, 井本逸勢 : 肺高血の進行を来した心房中隔欠損(小欠損孔) を伴う Inflammatory skin and bowel disease, neonatal, 1 (NISBD1) 疑いの一例, PH-CHDミーティング, 2019年8月.
94.	菅野幹雄, 本間友佳子, 黒部裕嗣, 藤本鋭貴, 北市隆, 早渕康信, 北川哲也 : 一般演題 PAIVS, Ebstein's anomalyに対するone and a half ventricle repair後の重度三尖弁逆流に対して自己心膜による弁尖延長を用いた三尖弁形成が奏功した一例, 第55回日本小児循環器学会総会・学術集会, 2019年6月.
95.	菅野幹雄, 本間友佳子, 黒部裕嗣, 北市隆, 早渕康信, 北川哲也 : PAIVS, Ebstein's anomalyに対するone and a half ventricle repair後の重度三尖弁逆流に対して自己心膜による弁尖延長を用いた三尖弁形成が奏功した一例, 第55回日本小児循環器学会総会・学術集会, 2019年6月.
96.	本間友佳子, 早渕康信, 香美祥二 : 光干渉断層像(Optical Coherence Tomography:OCT)による肺循環・肺血管病変の評価, 第92回日本超音波医学会学術集会, 2019年6月.
97.	早渕康信 : シンポジウム「心室中隔」心室中隔の収縮様式, 第55回日本小児循環器学会総会・学術集会, 2019年6月.
98.	加地剛, 早渕康信, 中川竜二, 稲村昇, 苛原稔 : 胎児診断により出生直後の左腕頭動脈肺動脈起始から左腕頭動脈孤立症への経過を観察できた1例, 第55回日本小児循環器学会総会・学術集会, 2019年6月.
99.	早渕康信, 本間友佳子, 香美祥二 : 右室圧から得られる新しい指標 RVω=(dP/dt_max - dP/dt_min)/(Pmax - Pmin) はTei index (MPI)に相当するglobal cardiac functionを簡便に再現性高く評価できる, 第55回日本小児循環器学会総会・学術集会, 2019年6月.
100.	早渕康信 : シンポジウム立体的に考える先天性心疾患「房室中隔欠損の解剖学的構造と超音波検査」, 第92回日本超音波医学会学術集会, 2019年5月.
101.	本間友佳子, 早渕康信, 香美祥二 : 僧帽弁輪部拡張早期反転運動(e2')の評価はアントラサイクリン系薬剤による心筋障害判定に有用である, 第30回日本心エコー図学会・学術集会, 2019年5月.
102.	小野朱美, 森一博, 早渕康信 : 川崎病急性期の左室心筋は浮腫によりstiffnessが上昇する:diastolic wall strainによる検討, 第30回日本心エコー図学会・学術集会, 2019年5月.
103.	加地剛, 早渕康信, 中川竜二, 祖川英至, 七條あつ子, 米谷直人, 須賀健一, 稲村昇, 苛原稔 : 胎児診断により出生直後の左腕頭動脈肺動脈起始から左腕頭動脈孤立症への経過を観察できた1例, 第30回日本心エコー図学会・学術集会, 2019年5月.
104.	早渕康信, 本間友佳子, 香美祥二 : Tei index (MPI) を表現する新しい心室圧波形指標ー小児心疾患症例の右室における検討-, 第30回日本心エコー図学会・学術集会, 2019年5月.
105.	早渕康信 : シンポジウム「生涯病としても先天性心疾患:ファロー四徴症」ファロー四徴症は何故，生涯病であるのか?, 第30回日本心エコー図学会・学術集会, 2019年5月.
106.	本間友佳子, 早渕康信, 本間友佳子 : 肥厚性骨関節症を発症した三尖弁閉鎖Fontan術後例の1成人例, 第33回日本小児循環器学会近畿・中国地方会, 2019年3月.
107.	早渕康信 : 先天性心疾患と学校生活, 平成30年度第4回徳島県医師会認定学校医研修会, 2019年2月.
108.	本間友佳子, 早渕康信, 小野朱美, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 両側肺静脈閉塞があるにもかかわらずFontan循環が成立した無脾症，総肺静脈還流異常，単心室の1例, 第25回日本小児肺循環研究会, 2019年2月.
109.	本間友佳子, 早渕康信, 小野朱美, 香美祥二 : ステント留置にside-cell拡大を加えて循環の安定を得た下心臓型総肺静脈還流異常の1新生児例, 第30回JPIC学術集会, 2019年1月.
110.	本間友佳子, 早渕康信, 香美祥二 : チアノーゼ性先天性心疾患症例では肺動脈vasa vasorumが増生する -フォンタン手術前症例における検討-, 徳島PHセミナー 2018, 2018年10月.
111.	早渕康信, 本間友佳子, 香美祥二 : 右心室圧波形を用いた右室弛緩能 (Elastic recoil, relaxation ) 評価, 第38回日本小児循環動態研究会・学術集会, 2018年10月.
112.	本間友佳子, 早渕康信, 香美祥二 : 両方向性グレン術後患者では肺動脈壁 vasa vasorum が増生する, 第29回徳島小児循環器談話会, 2018年9月.
113.	早渕康信 : 右室流出路狭窄を伴ったためにFontan循環となった症例, 第27回日本心エコー図学会夏期講習会, 2018年7月.
114.	早渕康信 : 心エコーで評価する右室流出路狭窄を合併する心疾患 -1心室修復から2心室修復まで-, 第27回日本心エコー図学会夏期講習会, 2018年7月.
115.	早渕康信 : 教育講演「右室収縮能と拡張能に関する突っ込んだ見方」, 第69回大阪小児循環器談話会, 2018年7月.
116.	菅野幹雄, 荒瀬裕己, 川谷洋平, 小野朱美, 黒部裕嗣, 藤本鋭貴, 北市隆, 早渕康信, 北川哲也 : NCCPによるmoderate ARを伴うVSD閉鎖の術中に緊急大動脈弁形成を要した一例, 第54回日本小児循環器学会総会・学術集会, 2018年7月.
117.	加地剛, 早渕康信, 須賀健一, 中川竜二, 苛原稔 : 出生後に高度気管狭窄症状を呈した左肺動脈右肺動脈起始(PA sling)の一例, 第54回日本小児循環器学会総会・学術集会, 2018年7月.
118.	本間友佳子, 早渕康信, 小野朱美, 香美祥二 : 両方向性グレン術後患者では肺動脈壁vasa vasorumが増生する ; Optical coherence tomography (OCT)による観察, 第54回日本小児循環器学会総会・学術集会, 2018年7月.
119.	小野朱美, 早渕康信, 本間友佳子, 香美祥二 : 僧帽弁輪部拡張早期運動の加速度(e'Ac: Acceleration of e' wave)と持続時間(e' dur: e' wave duration)は左室Elastic recoil/stiffnessの評価に有用である．, 第54回日本小児循環器学会総会・学術集会, 2018年7月.
120.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : 右室流入血流拡張早期波形解析による肺高血圧症患者の右室拡張能(Elastic recoil/Stiffness, Relaxation, Load)の評価, 2018年7月.
121.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : 左室流入血流拡張早期波形に減衰振動運動方程式を適用した左心室弛緩能 (Elastic recoil/Stiffness, Relaxation, Load)の評価, 第54回日本小児循環器学会総会・学術集会, 2018年7月.
122.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : 右心室圧波形を用いた右室拡張能評価の有用性 - 肺高血圧症例における Elastic recoil/stiffness, relaxation 評価 -, 第54回日本小児循環器学会総会・学術集会, 2018年7月.
123.	吉本夏実, 加地剛, 早渕康信, 今泉絢貴, 七條あつ子, 米谷直人, 須賀健一, 中川竜二, 苛原稔 : 出生後に高度気管狭窄症状を呈した左肺動脈右肺動脈起始(PA sling)の一例, 第91回日本超音波医学会学術集会, 2018年6月.
124.	本間友佳子, 早渕康信, 小野朱美, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 両側肺静脈閉塞があるにもかかわらずフォンタン循環が成立した無脾症，総肺静脈還流異常，単心室の1例, 第36回西日本小児呼吸循環HOT研究会, 2018年6月.
125.	小野朱美, 早渕康信, 香美祥二 : 右室圧低下は僧帽弁のtetheringを軽快させる -内科的加療のみで軽快した重症僧帽弁狭窄兼閉鎖不全の1乳児例の考察 -, 第29回日本心エコー図学会・学術集会, 2018年4月.
126.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : 左室流入血流拡張早期波形(E波波形)に減衰振動運動方程式を適用した左心室拡張能 (Elastic recoil/Stiffness, Relaxation, Load) の評価, 第29回日本心エコー図学会・学術集会, 2018年4月.
127.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : 右室流入血流拡張早期波(E波)の解析による右室拡張能(Elastic recoil/Stiffnes, Relaxation, Load) の評価方法, 第29回日本心エコー図学会・学術集会, 2018年4月.
128.	本間友佳子, 森一博, 井上美紀, 一宮千代, 早渕康信 : 左室長軸方向strainは川崎病での免疫グロブリン療法不応を予測できる, 第121回日本小児科学会学術集会, 2018年4月.
129.	林昌晃, 近田優介, 森西啓介, 小野朱美, 小野寺睦雄, 早渕康信, 西村匡司 : 航空機を利用した重症患者搬送の経験, 第45回日本集中治療医学会学術集会, 2018年2月.
130.	本間友佳子, 早渕康信, 小野朱美, 香美祥二 : 両方向性グレン術後患者では肺動脈壁 vasa vasorum が増生する - Optical coherence tomography (OCT)による観察 -, 第24回日本小児肺循環研究会, 2018年2月.
131.	小野朱美, 早渕康信, 香美祥二 : 大動脈弓拡大と動脈管閉塞を目的にステント留置を施行した大動脈縮窄の1例 -低出生体重の18トリソミー例における姑息的治療-, 第29回JPIC学術集会, 2018年1月.
132.	小野朱美, 早渕康信, 香美祥二 : 右室圧低下は僧帽弁のtetheringを軽快させる -内科的加療のみで軽快した重症僧帽弁狭窄兼閉鎖不全の1乳児例の考察 -, 第13回四国小児循環器病研究会, 2017年11月.
133.	東田好広, 郷司彩, 森達夫, 木下ゆき子, 早渕康信, 香美祥二, 井本逸勢 : バルプロ酸の投与によりてんかん発症を抑制できた結節性硬化症の一例, 第51回日本てんかん学会学術集会, 2017年11月.
134.	早渕康信 : 「心臓カテーテル法と心血管造影」, 日本小児循環器学会第9回教育セミナー Advanced course, 2017年10月.
135.	小野朱美, 早渕康信, 岡田朝美, 小谷裕美子, 香美祥二 : 母体糖尿病による心筋肥大と認識されていたPompe病の1乳児例, 第26回日本小児心筋疾患学会学術集会, 2017年10月.
136.	小野朱美, 早渕康信, 香美祥二 : 大動脈弓拡大と動脈管閉塞を目的にステント留置を施行した大動脈縮窄の18トリソミー, 第28回徳島小児循環器談話会, 2017年9月.
137.	小野朱美, 早渕康信, 市原裕子, 須賀健一, 中川竜二, 香美祥二 : 大動脈弓拡大と動脈管閉塞を目的にステント留置を施行した体重1544gの大動脈縮窄を呈した18トリソミー症例, 第35回中国四国地区小児循環器談話会, 2017年9月.
138.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : 右室拡張能の新しい評価方法 -減衰振動の運動力学方程式による評価-, 第53回日本小児循環器学会総会・学術集会, 2017年7月.
139.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : 「シンポジウム心機能を診る」減衰振動の運動方程式を適用した左心室拡張能 (Elastic recoil, Stiffness, Relaxation)の評価, 第53回日本小児循環器学会総会・学術集会, 2017年7月.
140.	小野朱美, 早渕康信, 本間友佳子, 香美祥二 : ファロー四徴症術後患者における肺動脈弁輪および三尖弁輪運動速度のIVA(Isovolumic acceleration)による右室機能解析, 第53回日本小児循環器学会総会・学術集会, 2017年7月.
141.	本間友佳子, 早渕康信, 小野朱美, 香美祥二 : 光干渉断層像(Optical Coherence Tomography:OCT)による先天性心疾患乳幼児における肺動脈病変の評価, 第53回日本小児循環器学会総会・学術集会, 2017年7月.
142.	加地剛, 早渕康信, 北川哲也, 苛原稔 : 診断時には左心低形成症候群への進行の予測が困難であった胎児大動脈弁狭窄の1例, 第53回日本小児循環器学会総会・学術集会, 2017年7月.
143.	荒瀬裕己, 川谷洋平, 菅野幹雄, 黒部裕嗣, 藤本鋭貴, 北市隆, 北川哲也, 小野朱美, 早渕康信 : 新生児期・乳児期BTシャント術と肺動脈発達との関係, 第53回日本小児循環器学会総会・学術集会, 2017年7月.
144.	菅野幹雄, 亀田香奈子, 荒瀬裕己, 川谷洋平, 小野朱美, 黒部裕嗣, 藤本鋭貴, 北市隆, 早渕康信, 北川哲也 : 出生後早期に手術介入を要した胎児期発症の左室内心臓腫瘍の一例, 第53回日本小児循環器学会総会・学術集会, 2017年7月.
145.	北市隆, 菅野幹雄, 荒瀬裕己, 亀田香奈子, 川谷洋平, 黒部裕嗣, 藤本鋭貴, 小野朱美, 早渕康信, 北川哲也 : 妊娠・出産を経たファロー四徴症手術症例の検討, 第60回関西胸部外科学会学術集会, 2017年6月.
146.	加地剛, 七條あつ子, 米谷直人, 早渕康信, 前田和寿, 苛原稔 : 胎児心室中隔欠損における欠損部位の違いによる短絡血流の差異, 第90回日本超音波医学会・学術集会, 2017年5月.
147.	早渕康信 : ワークショップ小児縦長心エコー「新生児・乳児における心エコー検査 - 縦長心エコーのなかの解剖学的・機能的評価 - 」, 第90回日本超音波医学会学術集会, 2017年5月.
148.	本間友佳子, 森一博, 井上美紀, 一宮千代, 早渕康信 : 川崎病急性期における左室 global longitudinal strain の臨床的意義, 第28回日本心エコー図学会・学術集会, 2017年4月.
149.	小野朱美, 早渕康信, 香美祥二 : ファロー四徴症術後患者における肺動脈弁輪運動速度のIVA(isovolumetric acceleration)の有用性に関する検討, 第28回日本心エコー図学会・学術集会, 2017年4月.
150.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : 肺動脈コンプライアンスの非侵襲的評価 -調和振動子を適用した解析-, 第28回日本心エコー図学会・学術集会, 2017年4月.
151.	小野朱美, 早渕康信, 市原裕子, 須賀健一, 中川竜二, 香美祥二 : 大動脈弓拡大と動脈管閉塞を目的にステント留置を施行した体重1500gの複合型大動脈縮窄を呈した18トリソミーの1例, 第55回徳島心・血管造影研究会, 2017年3月.
152.	小野朱美, 早渕康信, 香美祥二 : 拘束性障害から肺高血圧を来したアントラサイクリン誘発性心筋症の1例, 第31回日本小児循環器学会近畿・中四国地方会, 2017年3月.
153.	荒瀬裕己, 北市隆, 亀田香奈子, 川谷洋平, 黒部裕嗣, 藤本鋭貴, 北川哲也, 小野朱美, 早渕康信 : 二心室修復における左房直接還流型左上大静脈のreroutingについて, 第47回日本心臓血管外科学会学術集会, 2017年2月.
154.	中村香絵, 江原英治, 押谷知明, 藪田高生, 川崎有希, 加藤有子, 吉田葉子, 鈴木嗣敏, 川平洋一, 西垣恭一, 早渕康信, 村上洋介 : 動脈管結紮術後の遺残短絡に対しコイル塞栓術を行い完全閉塞したが，術後溶血のため回収した1例, 第28回日本Pediatric Interventional Cardiology学会学術集会, 2017年1月.
155.	小野朱美, 早渕康信, 香美祥二 : 無脾症候群・単心室症に合併した総肺静脈還流異常の垂直静脈・静脈管にステント留置を施行した6例の検討, 第28回日本Pediatric Interventional Cardiology学会学術集会, 2017年1月.
156.	大隅敬太, 早渕康信, 小野朱美, 市原裕子, 木下ゆき子, 東田好広, 漆原真樹, 香美祥二, 須賀健一, 中川竜二, 菅野幹雄, 北川哲也, 加地剛, 苛原稔, 井本逸勢 : 心臓腫瘍の診断を契機に胎児期から管理し，多臓器における系統的診療をすすめた結節性硬化症の一例, 第147回日本小児科学会徳島地方会, 2016年12月.
157.	小野朱美, 早渕康信, 戸梶成美, 香美祥二 : フォンタン術後に蛋白漏出性胃腸症(PLE)を発症した2症例, 第147回日本小児科学会徳島地方会(, 2016年12月.
158.	本間友佳子, 早渕康信, 小野朱美, 香美祥二, 井上美紀, 森一博, 佐田政隆, 添木武, 飛梅威, 松浦朋美 : Left venous valve由来部位の異常自動能が示唆された右房後中隔起源の心房頻拍・頻拍誘発性心筋症の1女児例, 第21回日本小児心電学会学術集会, 2016年11月.
159.	小野朱美, 早渕康信, 香美祥二, 中村香絵, 江原英治, 村上洋介 : 新生児期から拡張型心筋症の病態を呈した心室中隔欠損・動脈管開存を伴う1p36欠失症候群の1例, 第25回日本小児心筋疾患学会学術集会, 2016年10月.
160.	小野朱美, 早渕康信, 香美祥二 : 心筋虚血発作を繰り返した純型肺動脈閉鎖症(PAIVS)の一例, 第27回徳島小児循環器談話会, 2016年9月.
161.	早渕康信, 小野朱美, 香美祥二 : 呼吸停止と心停止を繰り返した1p36欠失症候群に伴う拡張型心筋症の1乳児例, 第34回中国四国地区小児循環器談話会, 2016年9月.
162.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : 非侵襲的な肺動脈コンプライアンスの評価方法 -組織ドプラ法を用いた肺動脈弁輪部運動速度による新たな解析ー, 第52回日本小児循環器学会総会・学術集会, 2016年7月.
163.	小野朱美, 早渕康信, 田中真波, 本間友佳子, 香美祥二 : 組織ドプラ法による肺動脈弁輪部運動速度の正常値の解析 ―右室流出路と流入路における機能の相違に関する解析―, 第52回日本小児循環器学会総会・学術集会, 2016年7月.
164.	本間友佳子, 早渕康信, 小野朱美, 香美祥二 : 光干渉断層像(Optical Coherence Tomography:OCT)を用いた肺血管病変の観察, 第52回日本小児循環器学会総会・学術集会, 2016年7月.
165.	加地剛, 早渕康信, 北川哲也, 苛原稔 : 胎児完全大血管転位症におけるカラードプラ超音波を用いた冠動脈走行評価, 第52回日本小児循環器学会総会・学術集会, 2016年7月.
166.	荒瀬裕己, 北川哲也, 北市隆, 藤本鋭貴, 黒部裕嗣, 木下肇, 早渕康信, 小野朱美 : 新生児期・乳児期 modified Blalock-Taussig shunt術のブラッシュアップ, 第52回日本小児循環器学会総会・学術集会, 2016年7月.
167.	北市隆, 荒瀬裕己, 木下肇, 黒部裕嗣, 藤本鋭貴, 浦田雅弘, 川人伸次, 小野朱美, 早渕康信, 北川哲也 : 細径プローブを用いたTransesophageal echocardiographyによりが小児心臓手術周術期の気道合併症は予防できる, 第52回日本小児循環器学会総会・学術集会, 2016年7月.
168.	荒瀬裕己, 亀田香奈子, 川谷洋平, 木下肇, 浦田雅弘, 黒部裕嗣, 藤本鋭貴, 北市隆, 北川哲也, 小野朱美, 早渕康信 : 純型肺動脈閉鎖症，類洞交通と肺分画症を合併し虚血発作を繰り返した1例, 第59回関西胸部外科学会学術集会, 2016年6月.
169.	小野朱美, 早渕康信, 香美祥二 : 拘束性障害を呈し肺高血圧を来したアントラサイクリン誘発性心筋症の1例, 第67回徳島心エコー図研究会, 2016年6月.
170.	本間友佳子, 森一博, 藤岡啓介, 佐々木亜由美, 寺田知正, 永井隆, 井上美紀, 早渕康信, 小野朱美, 香美祥二, 佐田政隆, 添木武, 飛梅威, 松浦朋美 : 持続する全身倦怠感を主訴とした異所性心房頻拍に伴う頻拍誘発性心筋症の1女児例, 第146回日本小児科学会徳島地方会, 2016年6月.
171.	早渕康信, 小野朱美, 香美祥二 : 成人先天性心疾患診療の現状と展望, 第146回日本小児科学会徳島地方会, 2016年6月.
172.	小野朱美, 早渕康信, 香美祥二, 北川哲也, 北市隆, 荒瀬裕己 : 怠薬による人工弁機能不全を来たし，急性心不全を呈した1例, 第146回日本小児科学会徳島地方会, 2016年6月.
173.	小野朱美, 早渕康信, 香美祥二 : 光干渉断層像(Optical Coherence Tomography: OCT) を用いたWilliams症候群における肺動脈病変の観察, 徳島肺高血圧症フォーラム2016, 2016年6月.
174.	小野朱美, 伊藤弘道, 阿部容子, 森達夫, 東田好広, 早渕康信, 成戸卓也, 井本逸勢, 香美祥二 : 重症蒼白型の憤怒痙攣に対してレベチラセタムが奏効した1p36欠失症候群の1女児例, 第58回日本小児神経学会学術集会, 2016年6月.
175.	松浦朋美, 添木武, 飛梅威, 上野理絵, 坂東左知子, 山田博胤, 若槻哲三, 佐田政隆, 早渕康信, 小野朱美 : 心房中隔起源の持続性心房頻拍により頻脈誘発性心筋症をきたした小児の1例, 日本内科学会第114回四国地方会, 2016年5月.
176.	本間友佳子, 森一博, 井上美紀, 寺田知正, 早渕康信 : M-mode心エコー図による新生児左室後壁diastolic wall strain, 第27回日本心エコー図学会学術集会, 2016年4月.
177.	小野朱美, 早渕康信, 香美祥二 : 拘束性障害を呈し肺高血圧を来したアントラサイクリン誘発性心筋症の1例, 第27回日本心エコー図学会学術集会, 2016年4月.
178.	早渕康信, 小野朱美, 本間友佳子, 香美祥二 : Tissue Doppler法とSpeckle tracking法を用いた右心室収縮様式の解析, 第27回日本心エコー図学会学術集会, 2016年4月.
179.	北市隆, 木下肇, 黒部裕嗣, 藤本鋭貴, 浦田雅弘, 早渕康信, 小野朱美, 北川哲也 : 小児期にVSD閉鎖を伴う心内修復を行った成人先天性心疾患におけるVSD閉鎖に関わる問題点の検討, 第116回日本外科学会定期学術集会, 2016年4月.
180.	早渕康信 : チーム医療セッション教育講演成人先天性心疾患診療に役立てる心エコー検査「未修復先天性心疾患者が大人になったら -エコーで何を視る-」, 第80回日本循環器学会学術集会, 2016年3月.
181.	早渕康信 : 心臓病のこどもが大人になること, とくしま難病支援ネットワーク講演会, 2016年3月.
182.	小野朱美, 早渕康信, 阪田美穂, 北市隆, 木下肇, 荒瀬裕己, 北川哲也, 香美祥二 : 心筋虚血発作を繰り返した純型肺動脈閉鎖症(PAIVS)の一例, 第30回日本小児循環器学会近畿・中四国地方会, 2016年2月.
183.	早渕康信 : 学童の不整脈, 徳島県医師会認定学校医研修会, 2016年2月.
184.	本間友佳子, 早渕康信, 小野朱美, 香美祥二 : 正常肺組織を犠牲にすることを前庭としてコイル塞栓術を施行した両側肺全区域びまん性肺動静脈瘻の1例, 第22回日本小児肺循環研究会, 2016年2月.
185.	小野朱美, 早渕康信, 香美祥二 : 合併した肺分画症に対するコイル塞栓術が著効した心筋虚血発作を繰り返す純型肺動脈閉鎖(PAIVS)の1新生児例, 第27回JPIC学会学術集会, 2016年1月.
186.	早渕康信 : ミニレクチャー「成人先天性心疾患をみるときにも役立つ区分診断法(Segmental Approach)の基礎のキソ」, 第8回蔵本エコーカンファレンス, 2016年1月.
187.	本間友佳子, 井上美紀, 寺田知正, 永井隆, 佐々木亜由美, 藤岡啓介, 大西康裕, 森一博, 小野朱美, 早渕康信, 香美祥二 : 重複大動脈弓の1乳児例, 第145回日本小児科学会徳島地方会, 2015年12月.
188.	小野朱美, 早渕康信, 阪田美穂, 香美祥二, 北市隆, 北川哲也, 井本逸勢 : 呼吸停止と心停止を繰り返した1p36欠失症候群に伴う拡張型心筋症の1乳児例, 第145回日本小児科学会徳島地方会, 2015年12月.
189.	阪田美穂, 早渕康信, 香美祥二 : 経皮的心肺補助(PCPS)装着下にカテーテルアブレーションを施行し，救命し得た心室頻拍の男児例, 第20回日本小児心電学会, 2015年11月.
190.	小野朱美, 早渕康信, 香美祥二 : 呼吸停止と心停止を繰り返した1p36欠失症候群に伴う拡張型心筋症の1乳児例, 第11回四国小児循環器病研究会学術講演会, 2015年11月.
191.	本間友佳子, 早渕康信, 小野朱美, 阪田美穂, 香美祥二 : 持続する低酸素血症の改善のために正常肺を犠牲とするコイル塞栓術を施行した両側肺全区域びまん性肺動静脈瘻の1例, 徳島PHセミナー 2015, 2015年11月.
192.	小野朱美, 早渕康信, 香美祥二 : 拡張型心筋症を呈した1p36欠失症候群の1乳児例, 第26回徳島小児循環器談話会, 2015年9月.
193.	田中真波, 早渕康信, 小野朱美, 香美祥二 : 肺動脈弁輪部運動速度を用いた右室流出路機能評価の試み, 第26回徳島小児循環器談話会, 2015年9月.
194.	小野朱美, 早渕康信, 香美祥二 : 拡張型心筋症を呈した1p36欠失症候群の1乳児例, 第26回徳島小児循環器談話会, 2015年9月.
195.	本間友佳子, 早渕康信, 井上美紀, 森一博 : M-mode 心エコーによる新生児左室後壁 diastolic wall strain, 第26回徳島小児循環器談話会, 2015年9月.
196.	乾宏彰, 加地剛, 七條あつ子, 髙橋洋平, 中山聡一朗, 早渕康信, 香美祥二, 苛原稔, 遠藤聡子 : 妊娠19週から経過を見ることができた胎児大動脈弁狭窄から左心低形成症候群への進行例, 第68回中国四国産科婦人科学会総会ならびに学術講演, 2015年9月.
197.	北市隆, 木下肇, 黒部裕嗣, 神原保, 藤本鋭貴, 川人伸次, 阪田美穂, 早渕康信, 北川哲也 : 小児開心術後反回神経麻痺における発生因子の検討, 第51回日本小児循環器学会総会・学術集会, 2015年7月.
198.	早渕康信, 阪田美穂, 香美祥二 : 新しい指標による右室機能解析 -肺動脈弁輪部運動速度を用いた右室流出路機能評価-, 第51回日本小児循環器学会総会・学術集会, 2015年7月.
199.	早渕康信, 阪田美穂, 香美祥二 : 光干渉断層像(Optica1 Coherence Tomography:OCT)を用いた先天性心疾患肺血管病変の観察, 第51回日本小児循環器学会総会・学術集会, 2015年7月.
200.	本間友佳子, 早渕康信, 阪田美穂, 香美祥二 : 類洞交通を介した駆出によって上行大動脈順行性血流と冠状動脈貫流を認めた大動脈弁閉鎖の1例, 第51回日本小児循環器学会総会・学術集会, 2015年7月.
201.	小野朱美, 早渕康信, 阪田美穂, 香美祥二, 井上美紀, 森一博 : 光干渉断層像(Optica1 Coherence Tomography:OCT)を用いたWilliams症候群における肺動脈病変の観察, 第51回日本小児循環器学会総会・学術集会, 2015年7月.
202.	阪田美穂, 早渕康信, 香美祥二 : 右室圧負荷を有する先天性心疾患症例における手術前後のDWSの変化, 第51回日本小児循環器学会総会・学術集会, 2015年7月.
203.	小野朱美, 早渕康信, 香美祥二 : 肺分画症にコイル塞栓術によって心筋虚血症状の改善を得た右室低形成，肺動脈閉鎖，冠状動脈異常の1乳児例, 第52回徳島心血管造影研究会, 2015年7月.
204.	小野朱美, 早渕康信, 阪田美穂, 香美祥二, 木下肇, 北市隆, 北川哲也 : 心筋虚血発作を繰り返した純型肺動脈閉鎖症の1例, 第144回日本小児科学会徳島地方会, 2015年6月.
205.	小野朱美, 早渕康信, 香美祥二 : 乳児特発性僧帽弁腱索断裂症術後に進行性の三尖弁閉鎖不全を呈した1女児例, 第65回徳島心エコー図研究会, 2015年6月.
206.	早渕康信, 阪田美穂, 小野朱美, 香美祥二 : 新生児期から持続する間質性肺炎のために肺高血圧をきたした女児例, 第33回西日本小児呼吸循環HOT研究会, 2015年6月.
207.	小野朱美, 早渕康信, 香美祥二 : 光干渉断層像(Optical Coherence Tomography: OCT) を用いたWilliams症候群における肺動脈病変の観察, 徳島肺高血圧症フォーラム2016, 2015年6月.
208.	乾宏彰, 加地剛, 七條あつ子, 髙橋洋平, 中山聡一朗, 苛原稔, 早渕康信, 香美祥二, 遠藤聡子 : 胎児期に大動脈弁狭窄から左心低形成症候群に進行した1例, 第107回徳島周産期研究会, 2015年5月.
209.	早渕康信, 阪田美穂, 香美祥二 : 光干渉断層像(Optica1 Coherence Tomography:OCT)を用いた先天性心疾患肺血管病変の観察, 第118回日本小児科学会学術集会, 2015年4月.
210.	早渕康信, 阪田美穂, 香美祥二 : 新しい指標を用いた右室機能解析 -circumferential strain (右室自由壁円周方向収縮)と肺動脈弁輪部運動速度(右室流出路機能)-, 第26回日本心エコー図学会学術集会, 2015年3月.
211.	早渕康信, 阪田美穂, 香美祥二 : 新しい指標を用いた右室機能解析 -circumferential strain (右室自由壁円周方向収縮)と肺動脈弁輪部運動速度(右室流出路機能)-, 第26回日本心エコー図学会学術集会, 2015年3月.
212.	阪田美穂, 早渕康信, 近藤朝美, 永井隆, 岡村和美, 杉本真弓, 伊藤弘道, 漆原真樹, 近藤秀治, 渡邊浩良, 香美祥二, 木下肇, 北市隆, 北川哲也 : 急激な循環不全を呈し，慢性期に拡張型心筋症へ移行した急性壊死性好酸球性心筋炎の一例, 第29回日本小児循環器学会近畿中四国地方会, 2015年3月.
213.	阪田美穂, 早渕康信, 近藤朝美, 永井隆, 岡村和美, 杉本真弓, 伊藤弘道, 漆原真樹, 近藤秀治, 渡邊浩良, 香美祥二, 木下肇, 北市隆, 北川哲也 : 急激な循環不全を呈し，慢性期に拡張型心筋症へ移行した急性壊死性好酸球性心筋炎の一例, 第29回日本小児循環器学会近畿中四国地方会, 2015年3月.
214.	早渕康信 : 先天性心疾患と学校生活, 第3回徳島県医師会認定学校医研修会, 2015年2月.
215.	加地剛, 七條あつ子, 髙橋洋平, 中山聡一朗, 前田和寿, 苛原稔, 早渕康信, 香美祥二 : 完全大血管転位における冠動脈走行の出生前評価, 第21回日本胎児心臓病学会学術集会, 2015年2月.
216.	早渕康信, 阪田美穂, 香美祥二 : 正常肺組織を犠牲にすることを前提としてコイル塞栓術を施行した両側肺全区域びまん性肺動静脈瘻の1例, 第26回日本Pediatric Interventional Cardiology学会, 2015年1月.
217.	早渕康信, 阪田美穂, 香美祥二 : 正常肺組織を犠牲にすることを前提としてコイル塞栓術を施行した両側肺全区域びまん性肺動静脈瘻の1例, 第26回日本Pediatric Interventional Cardiology学会, 2015年1月.
218.	早渕康信, 阪田美穂, 香美祥二 : 正常肺の犠牲を前提としてカテーテル治療を施行した両側肺全区域びまん性肺動静脈瘻の1例, 第143回日本小児科学会徳島地方会, 2014年12月.
219.	石井亜由美, 西川幸治, 伊勢孝之, 高川由利子, 八木秀介, 岩瀬俊, 木下肇, 阪田美穂, 早渕康信, 赤池雅史, 加藤真介, 北川哲也, 佐田政隆 : 単心室症患児の開心術後に心臓リハビリテーションを有効に施行し得た一例, 第105回日本循環器学会四国地方会, 2014年12月.
220.	北市隆, 木下肇, 黒部裕嗣, 神原保, 藤本鋭貴, 阪田美穂, 早渕康信, 北川哲也 : 小児開心術後縦隔炎に対するVAC療法と閉胸のタイミングについて, 第10回四国小児循環器病研究会, 2014年11月.
221.	阪田美穂, 早渕康信, 近藤朝美, 永井隆, 岡村和美, 杉本真弓, 伊藤弘道, 近藤秀治, 渡邊浩良, 香美祥二 : 拡張型心筋症へ移行した急性壊死性好酸球性心筋炎の一例, 第23回日本小児心筋疾患学会, 2014年10月.
222.	早渕康信 : 心房中隔欠損症のエコー診断 -小児から成人まで-, 日本超音波医学会第24回四国地方学術集会ならびに第13回四国地方会講習会, 2014年10月.
223.	阪田美穂, 早渕康信, 苛原誠, 香美祥二 : ボセンタンが奏効した多脾症候群 Bidirectional Glenn術後の1例, 成人先天性心疾患(ACHD)と肺高血圧症(PAH)を考える会 in Tokushima, 2014年9月.
224.	早渕康信 : こどもの心不全について考えること, 第188回徳島県小児科医会例会・学術講演会ならびに第29回徳島県小児科合同症例検討会, 2014年9月.
225.	阪田美穂, 早渕康信, 香美祥二 : カテーテル治療後に認められたFibromyxoid excrescence of aortic valveの1例, 第25回徳島小児循環器談話会, 2014年9月.
226.	坂東左知子, 添木武, 飛梅威, 松浦朋美, 齋藤友子, 高島啓, 坂東美佳, 山崎宙, 伊勢孝之, 發知淳子, 山口浩司, 八木秀介, 岩瀬俊, 山田博胤, 若槻哲三, 阪田美穂, 早渕康信, 井上美紀, 森一博, 木下学, 佐田政隆 : 薬剤抵抗性特発性心室頻拍に対し，PCPS下にアブレーション治療を施行し，社会復帰に成功した若年例の一例, 第104回日本循環器学会中国・四国合同地方会, 2014年7月.
227.	早渕康信, 阪田美穂, 香美祥二 : シンポジウム「右室を視る-最新の画像診断-」多方向からの右室機能解析の重要性 -右室自由壁円周方向の収縮(Circumferential strain)と右室流出路の収縮(肺動脈弁輪運動速度)の解析-, 第50回日本小児循環器学会総会・学術集会, 2014年7月.
228.	阪田美穂, 早渕康信, 森一博, 香美祥二 : 右室圧負荷を有する先天性心疾患症例では心室中隔の心筋伸展性が低下する-DWSを用いた心室中隔のスティフネス測定-, 第50回日本小児循環器学会総会, 2014年7月.
229.	北市隆, 菅野幹雄, 木下肇, 中山泰介, 黒部裕嗣, 神原保, 藤本鋭貴, 川人伸次, 阪田美穂, 早渕康信, 北川哲也 : 小児心臓手術時における経食道心エコーの合併症の検討, 第50回日本小児循環器学会総会・学術集会, 2014年7月.
230.	阪田美穂, 早渕康信, 森一博, 阪田美穂 : 右室圧負荷を有する先天性心疾患症例では心室中隔の心筋伸展性が低下する -DWSを用いた心室中隔のスティフネス測定-, 第50回日本小児循環器学会総会・学術集会, 2014年7月.
231.	早渕康信, 阪田美穂, 小野朱美, 香美祥二 : 光干渉断層像 (Optical Coherence Tomography: OCT) を用いた特発性肺動脈性肺高血圧症における肺血管病変の観察, 第50回日本小児循環器学会総会・学術集会, 2014年7月.
232.	早渕康信, 阪田美穂, 香美祥二 : 多方向からの右室機能解析の重要性 -右室自由壁円周方向の収縮(Circumferential strain)と右室流出路の収縮(肺動脈弁輪運動速度)の解析-, 第50回日本小児循環器学会総会・学術集会, 2014年7月.
233.	北市隆, 菅野幹雄, 木下肇, 中山泰介, 黒部裕嗣, 神原保, 藤本鋭貴, 川人伸次, 阪田美穂, 早渕康信, 北川哲也 : 小児心臓手術時における経食道心エコーの合併症の検討, 第50回日本小児循環器学会総会・学術集会, 2014年7月.
234.	近藤朝美, 永井隆, 岡村和美, 阪田美穂, 杉本真弓, 伊藤弘道, 漆原真樹, 渡邊浩良, 早渕康信, 香美祥二 : 激症型心筋炎を来した特発性好酸球増多症の一例, 第142回日本小児科学会徳島地方会, 2014年6月.
235.	阪田美穂, 早渕康信, 香美祥二 : 段階的カテーテル治療によりフォンタン手術が可能となった三尖弁閉鎖症の一例, 第142回日本小児科学会徳島地方会, 2014年6月.
236.	早渕康信, 阪田美穂, 寺田知正, 香美祥二 : 治療方針を苦慮した換気不全が増悪する肺動脈弁欠損術後症例, 第142回日本小児科学会徳島地方会, 2014年6月.
237.	田中佑樹, 一宮千代, 立岩真紀, 平野志乃, 河野郁代, 井上美紀, 森一博, 早渕康信 : Speckle tracking法が有用であった左冠動脈肺動脈起始の乳児例, 第39回日本超音波検査学会学術集会, 2014年6月.
238.	早渕康信, 阪田美穂, 寺田知正, 香美祥二 : 持続する換気不全を呈した肺動脈弁欠損術後の1例, 第32回西日本小児循環器HOT研究会, 2014年6月.
239.	阪田美穂, 早渕康信, 近藤朝美, 永井隆, 岡村和美, 杉本真弓, 漆原真樹, 近藤秀治, 渡邊浩良, 香美祥二 : 経皮的心肺補助が必要であった急性壊死性好酸球性心筋炎の一例, 第63回徳島心エコー図研究会, 2014年5月.
240.	阪田美穂, 早渕康信, 香美祥二 : 右室圧負荷を有する先天性心疾患症例では心室中隔の心筋伸展性が低下する -DWSを用いた心室中隔のスティフネス測定-, 第25回日本心エコー図学会学術集会, 2014年4月.
241.	早渕康信, 阪田美穂, 香美祥二 : 右室自由壁のCircumferential strainは，Longitudinal strainよりも右室機能解析に有用である, 第25回日本心エコー図学会学術集会, 2014年4月.
242.	早渕康信, 阪田美穂, 香美祥二 : 成人先天性心疾患術後症例における右室機能解析の問題点 -ファロー四徴症心内修復術後およびラステリ術後患者の右心室-, 第25回日本心エコー図学会学術集会, 2014年4月.
243.	早渕康信, 小野朱美, 阪田美穂, 香美祥二 : Optical Coherence Tomography(OCT)で肺動脈を観察した特発性肺動脈性肺高血圧症, 症例から学ぶ肺高血圧症 in Tokushima, 2014年3月.
244.	阪田美穂, 早渕康信, 香美祥二, 北市隆, 藤本鋭貴, 神原保, 黒部裕嗣, 北川哲也, 添木武, 飛梅威, 松浦朋美, 板東左知子, 佐田政隆 : 経皮的心肺補助装置(PCPS)装着下にカテーテルアブレーションを施行し，救命し得た心室頻拍1男児例, 第28回日本小児循環器学会近畿・中四国地方会, 2014年3月.
245.	坂東左知子, 添木武, 飛梅威, 松浦朋美, 佐田政隆, 阪田美穂, 早渕康信, 香美祥二, 井上美紀, 森一博, 木下学 : 薬剤抵抗性の特発性心室頻拍に対しPCPS下にカテーテルアブレーション治療を施行し，社会復帰に成功した一例, 第248回徳島医学会学術集会, 2014年2月.
246.	小野朱美, 早渕康信, 阪田美穂, 香美祥二 : 診断時にOptical Coherence Tomography(OCT)で肺動脈を観察した特発性肺動脈性肺高血圧症の1男児例, 第2回中四国肺循環動態フォーラム, 2014年2月.
247.	阪田美穂, 早渕康信, 香美祥二 : カテーテル治療後に出現し，摘出術を要したFibromyxoid excrescence of aortic valve, 第25回日本Pediatric Interventional Cardiology 学会学術集会, 2014年1月.
248.	早渕康信, 阪田美穂, 近藤朝美 : 左室心筋緻密化障害様の所見を呈した乳児白血病治療後心筋症, 第9回四国小児循環器研究会, 2013年11月.
249.	早渕康信, 阪田美穂, 近藤朝美, 香美祥二 : 乳児白血病治療後に心筋症を呈した1例, 第22回日本小児心筋疾患学会, 2013年10月.
250.	近藤朝美, 早渕康信, 阪田美穂, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 左冠状動脈肺動脈起始症の乳児例, 第24回徳島小児循環器談話会, 2013年9月.
251.	木下肇, 中山泰介, 菅野幹雄, 黒部裕嗣, 神原保, 藤本鋭貴, 北市隆, 北川哲也, 阪田美穂, 早渕康信 : 重度僧帽弁逆流症を伴う左冠動脈肺動脈起始症の1 例, 第88回中国四国外科学会総会, 2013年9月.
252.	早渕康信, 阪田美穂, 渡辺典子, 香美祥二 : 心室中隔は2層構造を呈し, 異なる収縮運動を有している -Speckle tracking法を用いた2心筋線維層のRotation(回転運動)の検討-, 第49回日本小児循環器学会総会・学術集会, 2013年7月.
253.	阪田美穂, 早渕康信, 香美祥二 : 肺欝血・肺静脈拡大を反映する心エコー検査拡張能指標の検出 -心室中隔欠損による左心前負荷増加群における検討-, 第49回日本小児循環器学会総会・学術集会, 2013年7月.
254.	北市隆, 菅野幹雄, 藤本鋭貴, 神原保, 中山泰介, 木下肇, 早渕康信, 阪田美穂, 北川哲也 : 乳幼児期PA/VSDに対するRastelli型手術の早期-遠隔期成績と問題点, 第49回日本小児循環器学会総会・学術集会, 2013年7月.
255.	北市隆, 菅野幹雄, 藤本鋭貴, 神原保, 中山泰介, 木下肇, 早渕康信, 阪田美穂, 北川哲也 : 乳幼児期PA/VSDに対するRastelli型手術の早期-遠隔期成績と問題点, 第49回日本小児循環器学会総会・学術集会, 2013年7月.
256.	木下肇, 中山泰介, 菅野幹雄, 黒部裕嗣, 神原保, 藤本鋭貴, 北市隆, 阪田美穂, 早渕康信, 北川哲也 : 乳児期特発性腱索断裂による急性僧帽弁閉鎖不全症の2例, 第49回日本小児循環器学会総会・学術集会, 2013年7月.
257.	早渕康信, 阪田美穂, 渡辺典子 : 心室中隔は2層構造を呈し, 異なる収縮運動を有している -Speckle tracking法を用いた2心筋線維層のRotation(回転運動)の検討-, 第49回日本小児循環器学会総会・学術集会, 2013年7月.
258.	阪田美穂, 早渕康信, 香美祥二 : 肺うっ血・肺静脈拡大を反映する心エコー検査拡張指標の検出, 第49回日本小児循環器学会総会・学術集会(, 2013年7月.
259.	森一博, 早渕康信 : M-mode心エコー図による左室後壁``Diastolic wall strain''の経年的変化, 第49回日本小児循環器学会総会・学術集会(, 2013年7月.
260.	近藤朝美, 早渕康信, 阪田美穂, 香美祥二, 木下肇, 菅野幹雄, 北市隆, 北川哲也 : 左冠状動脈肺動脈起始症の乳児例, 第48回徳島心・血管造影研究会, 2013年7月.
261.	早渕康信, 阪田美穂, 香美祥二 : 新生児期から持続する間質性肺炎のために肺高血圧をきたした女児例, 第1回徳島肺高血圧フォーラム2013, 2013年5月.
262.	阪田美穂, 早渕康信, 香美祥二 : 著しい右室拡大を呈した乳児例, , 2013年5月.
263.	早渕康信, 阪田美穂, 香美祥二 : シンポジウム「成人先天性心疾患 Up to Date 先天性心疾患の画像診断-医療画像診断機器(modality)の比較と総合的診断-, 第24回日本心エコー図学会学術集会, 2013年4月.
264.	阪田美穂, 早渕康信, 香美祥二 : 肺欝血・肺静脈拡大を反映する心エコー検査指標の検討 -心室中隔欠損による左室前負荷増加群における検討-, 2013年4月.
265.	早渕康信, 阪田美穂, 香美祥二 : 心室中隔は2層構造を示し，異なるRotation(回転運動)を示す, 第24回日本心エコー図学会学術集会, 2013年4月.
266.	早渕康信, 阪田美穂, 香美祥二 : Fontan術後遠隔期の肝障害，肝線維症に対するウルソデオキシコール酸の効果, 第116回日本小児科学会学術集会, 2013年4月.
267.	阪田美穂, 早渕康信, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 進行性に3枝ブロックを認め，ペースメーカー治療を要した新生児例, 第27回日本小児循環器学会近畿中四国地方会, 2013年3月.
268.	北市隆, 菅野幹雄, 藤本鋭貴, 神原保, 木下肇, 中山泰介, 阪田美穂, 早渕康信, 北川哲也 : 側方開胸によるIAA/CoAに対する大動脈再建の適応と限界, 第43回日本心臓血管外科学会学術総会, 2013年2月.
269.	北市隆, 菅野幹雄, 藤本鋭貴, 神原保, 木下肇, 中山泰介, 阪田美穂, 早渕康信, 北川哲也 : 側方開胸によるIAA/CoAに対する大動脈再建の適応と限界, 第43回日本心臓血管外科学会学術総会, 2013年2月.
270.	万野朱美, 早渕康信, 香美祥二, 三河浩一, 松岡優 : 徳島県における学校心電図検診 -最近10年間の状況-, 第45回若年者心疾患生活習慣病対策協議会総会, 2013年1月.
271.	早渕康信 : 学校生活で悩む不整脈症例 -この症例をどう扱うか?-, 第45回若年者心疾患生活習慣病対策協議会総会, 2013年1月.
272.	阪田美穂, 早渕康信, 香美祥二 : 総肺静脈還流異常症に対するステント留置術の有用性と問題点, 第24回日本Pediatric Interventional Cardiology 学会学術集会, 2013年1月.
273.	鈴江真史, 阪田美穂, 早渕康信, 香美祥二, 中川竜二, 渡辺典子, 西條隆彦, 菅野幹雄, 北山哲也 : 9番染色体部分トリソミー・21番染色体部分モノソミーの1例, 第64回日本小児科学会中国四国地方会, 2012年12月.
274.	市原裕子, 早渕康信, 阪田美穂, 香美祥二, 万野朱美 : 右室内血栓を認めた純型肺動脈閉鎖の2例, 第139回日本小児科学会徳島地方会, 2012年12月.
275.	阪田美穂, 早渕康信, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 進行性心臓伝導障害の新生症例, 第139回日本小児科学会徳島地方会, 2012年12月.
276.	万野朱美, 早渕康信, 香美祥二, 三河浩一, 松岡優, 森一博 : 徳島県における学校心電図検診の10年間のあゆみ, 第139回日本小児科学会徳島地方会, 2012年12月.
277.	市原裕子, 早渕康信, 阪田美穂, 万野朱美, 香美祥二 : 右室内血栓を認めたPAIVSの2症例, 第64回日本小児科学会中国四国地方会, 2012年11月.
278.	早渕康信, 阪田美穂, 苛原誠, 阿部容子, 香美祥二 : Anodal stimulation(陽極刺激)を認め，心室細動を来したCRT施行の1男児例, 第17回日本小児心電学研究会, 2012年10月.
279.	苛原誠, 早渕康信, 阪田美穂, 香美祥二 : 胸痛から心肺停止を来たした多脾症候群の1例, 第23回徳島小児循環器談話会, 2012年9月.
280.	阪田美穂, 早渕康信, 香美祥二 : 心不全の増悪によって交互脈を認めたFontan術後症例, 第23回徳島小児循環器談話会, 2012年9月.
281.	市原裕子, 早渕康信, 阪田美穂, 万野朱美, 香美祥二 : 右室内血栓を認めたPAIVSの2症例, 第30回中国四国地区小児循環器談話会, 2012年9月.
282.	東田好広, 伊藤弘道, 永井隆, 阪田美穂, 漆原真樹, 近藤秀治, 早渕康信, 森健治, 香美祥二 : West症候群を合併した21番染色体部分異常の1例, 第48回日本小児循環器学会総会・学術集会, 2012年7月.
283.	阪田美穂, 早渕康信, 大西達也, 香美祥二 : Dual Dopller法を用いた拡張早期左室流入血流と僧帽弁輪運動の時相解析による左室拡張障害診断, 第48回日本小児循環器学会総会・学術集会, 2012年7月.
284.	早渕康信, 阪田美穂, 大西達也, 渡辺典子, 香美祥二 : ontan術後患者の肝機能障害・肝線維症に対するウルソデオキシコール酸の効果, 第48回日本小児循環器学会総会・学術集会, 2012年7月.
285.	早渕康信, 阪田美穂, 大西達也, 渡辺典子, 香美祥二 : 心室中隔は2層に区分され，それらのasynchronyは心室中隔機能低下を惹起する, 第48回日本小児循環器学会総会・学術集会, 2012年7月.
286.	菅野幹雄, 北市隆, 中山泰介, 木下肇, 神原保, 藤本鋭貴, 大西達也, 阪田美穂, 早渕康信, 北川哲也 : ファロー四微症における手術時期および術式について, 第48回日本小児循環器学会総会, 2012年7月.
287.	北市隆, 菅野幹雄, 藤本鋭貴, 神原保, 中山泰介, 木下肇, 早渕康信, 阪田美穂, 大西達也, 北川哲也 : 総肺静脈還流異常症術後の左肺静脈狭窄に対するSnap back sutureless technique の適応と問題点, 第48回日本小児循環器学会総会, 2012年7月.
288.	藤岡啓介, 東田好広, 伊藤弘道, 永井隆, 阪田美穂, 漆原真樹, 近藤秀治, 早渕康信, 森健治, 香美祥二 : West症候群を合併した21番染色体部分異常の1例, 第138回日本小児科学会徳島地方会, 2012年6月.
289.	庄野実希, 早渕康信, 阪田美穂, 大西達也, 富本亜由美, 香美祥二 : コイル塞栓術とバルーン拡大術に新しいデバイスを用いて工夫を凝らした心室中隔欠損・肺動脈閉鎖の1例, 第138回日本小児科学会徳島地方会, 2012年6月.
290.	菅野幹雄, 中山泰介, 木下肇, 黒部裕嗣, 神原保, 藤本鋭貴, 北市隆, 大西達也, 阪田美穂, 早渕康信, 北川哲也 : 成人期先天性心疾患患者の大動脈手術の経験, 第40回日本血管外科学会学術総会, 2012年5月.
291.	阪田美穂, 早渕康信, 大西達也, 庄野実希, 香美祥二 : 純型肺動脈閉鎖の新生児症例, 第59回徳島心エコー図研究会, 2012年4月.
292.	阪田美穂, 早渕康信, 大西達也, 香美祥二 : 先天性心疾患小児症例におけるdual Doppler法を用いた拡張早期左室流入血流と僧帽弁輪運動の時相解析, 第23回日本心エコー図学会学術集会, 2012年4月.
293.	早渕康信, 阪田美穂, 大西達也, 香美祥二 : 心室中隔は2層に区別され，心室中隔欠損閉鎖術施行患者ではasynchronyが存在する, 第23回日本心エコー図学会学術集会, 2012年4月.
294.	北市隆, 菅野幹雄, 藤本鋭貴, 神原保, 中山泰介, 木下肇, 早渕康信, 阪田美穂, 大西達也, 北川哲也 : 右室流出路再建後の肺動脈弁逆流に対する再手術例の検討, 第42回日本心臓血管外科学会学術総会, 2012年4月.
295.	大西達也, 早渕康信, 阪田美穂, 苛原誠, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 静脈管にステント留置を施行した下心臓型総肺静脈還流異常の1新生児例, 第45回徳島心血管造影研究会, 2012年3月.
296.	早渕康信, 阪田美穂, 大西達也, 苛原誠, 阿部容子, 香美祥二 : 陽極刺激を認め，心室細動を来した心臓再同期療法施行の1男児例, 第26回日本小児循環器学会近畿・中四国地方会, 2012年3月.
297.	大西達也, 早渕康信, 阪田美穂, 苛原誠, 香美祥二, 加地剛, 前田和寿, 苛原稔 : 無脾症候群・下心臓型肺静脈還流異常に対する静脈管ステント留置部病変の経胸壁・血管内エコーによる経時的観察, 第23回日本Pediatric Interventional Cardiology学会学術集会, 2012年1月.
298.	早渕康信, 阪田美穂, 大西達也, 苛原誠, 阿部容子, 香美祥二 : Anodal stimulation(陽極刺激)を認め，心室細動を来した CRT(心臓再同期療法)施行の男児例, 第137回日本小児科学会徳島地方会, 2011年12月.
299.	大西達也, 早渕康信, 阪田美穂, 苛原誠, 岡部寛, 香美祥二, 中川竜二, 西條隆彦 : ステント留置により肺静脈閉塞を回避しえた総肺静脈還流異常の3新生児例, 第137回日本小児科学会徳島地方会, 2011年12月.
300.	阪田美穂, 早渕康信, 大西達也, 香美祥二 : 肺高血圧症治療薬の使用状況に関する検討, 第137回に本小児科学会徳島地方会, 2011年12月.
301.	中川竜二, 西條隆彦, 渡辺典子, 早渕康信, 香美祥二 : 過去10年間に当院NICUへ入院した先天性心疾患症例の検討, 第63回中国四国小児科学会, 2011年11月.
302.	中川竜二, 西條隆彦, 早渕康信, 香美祥二 : 過去10年間に当院NICUへ入院した先天性心疾患症例の検討, 第63回中国四国小児科学会, 2011年11月.
303.	大西達也, 早渕康信, 阪田美穂, 苛原誠, 中川竜二, 西條隆彦, 香美祥二 : 下心臓型総肺静脈還流異常に対する静脈管ステント留置術を施行した無脾症候群の1新生児例, 第7回四国小児循環器病研究会, 2011年10月.
304.	Nabo Mohamed Helmy Manal, 早渕康信 : Stent-in-Stenting が著効した完全大血管転換症Jatene術後の肺動脈狭窄の1例, 第22回徳島小児循環器談話会, 2011年10月.
305.	早渕康信 : ミニレクチャー「小児のブルガダ症候群」, 第22回徳島小児循環器談話会, 2011年10月.
306.	苛原誠, 早渕康信, 阪田美穂, 大西達也, 香美祥二 : 胸痛から心肺停止を来した多脾症候群の1例, 第29回中国四国地区小児循環器談話会, 2011年9月.
307.	早渕康信, 阪田美穂, 大西達也, 香美祥二 : 心臓カテーテル検査では描出できずMDCTでのみ診断出来る症に循環器疾患に関する考察, 第114回日本小児科学会学術集会, 2011年8月.
308.	阪田美穂, 早渕康信, 井上美紀, 香美祥二 : 先天性心疾患における心不全指標としての赤血球粒度分布幅RDWの有用性, 第46回日本小児循環器学会学術集会, 2011年7月.
309.	大西達也, 早渕康信, 阪田美穂, 井上美紀, 香美祥二 : ファロー四徴症の術後患者における組織ドプラ法とカテーテル検査指標の関連性の検討, 第47回日本小児循環器学会総会・学術集会, 2011年7月.
310.	宮崎達志, 多田羅勝義, 阪田美穂, 早渕康信, 香美祥二, 森一博, 井上美紀 : Duchenne型筋ジストロフィー左室後壁外側に認められる非虚血性局所心筋障害と自律神経機能異常との関連, 第47回日本小児循環器学会総会・学術集会, 2011年7月.
311.	早渕康信, 阪田美穂, 大西達也, 渡辺典子, 香美祥二 : 心室中隔を右室側と左室側に区別したストレイン解析は右室機能評価に有用である, 第47回日本小児循環器学会総会・学術集会, 2011年7月.
312.	阪田美穂, 早渕康信, 大西達也, 苛原誠, 香美祥二 : 心不全の増悪とともに交互脈を認めた Fontan 術後症例, 第136回日本小児科学会徳島地方会, 2011年6月.
313.	大西達也, 早渕康信, 阪田美穂, 苛原誠, 香美祥二, 渡辺典子, 中川竜二, 西條隆彦, 加地剛, 前田和寿, 苛原稔, 菅野幹雄, 北市隆, 北川哲也 : 静脈管ステント留置術を行った無脾症に伴う下心臓型総肺静脈還流異常症の新生児例, 第136回日本小児科学会徳島地方会, 2011年6月.
314.	苛原誠, 早渕康信, 阪田美穂, 大西達也, 香美祥二 : 著明な低酸素血症による狭心症発作と心肺停止を来した多脾症候群の1例, 第136回日本小児科学会徳島地方会, 2011年6月.
315.	阪田美穂, 早渕康信, 大西達也, 寺田知正, 中川竜二, 西條隆彦, 香美祥二, 北市隆, 北川哲也 : 長期のECMO施行と人工呼吸管理を要した肺動脈弁欠損症の1例, 第29回西日本小児循環器HOT研究会, 2011年6月.
316.	阪田美穂, 早渕康信, 大西達也, 寺田知正, 中川竜二, 西條隆彦, 香美祥二, 北市隆, 北川哲也 : 長期のECMO施行と人工呼吸管理を要した肺動脈弁欠損症の1例, 第29回西日本小児循環器HOT研究会, 2011年6月.
317.	中川竜二, 西條隆彦, 須賀健一, 渡辺典子, 大西達也, 阪田美穂, 早渕康信, 香美祥二, 加地剛, 前田和寿, 苛原稔 : 生後早期に静脈管ステント留置術を行った無脾症に伴う下心臓型総肺静脈環流異常症の一例, 第28回四国新生児医療研究会, 2011年5月.
318.	中山泰介, 菅野幹雄, 元木達夫, 黒部裕嗣, 神原保, 北市隆, 北川哲也, 寺田知正, 大西達也, 阪田美穂, 早渕康信, 今中秀光, 西村匡司 : 難治性小児乳び胸に対するオクトレオチドの使用経験, 第98回日本循環器学会中国四国合同地方会, 2011年5月.
319.	大西達也, 早渕康信, 阪田美穂, 苛原誠, 香美祥二, 加地剛, 前田和寿, 苛原稔, 菅野幹雄, 北市隆, 北川哲也 : 下心臓型総肺静脈還流異常に対して静脈管にステント留置を施行した1新生児例, 第98回日本循環器学会中国四国合同地方会, 2011年5月.
320.	宮崎達志, 多田羅勝義, 阪田美穂, 早渕康信, 香美祥二, 森一博, 井上美紀 : Duchenne型筋ジストロフィー左室後壁外膜側優位に認められる非虚血性局所心筋障害-自律神経機能異常との関連-, 第22回日本心エコー図学会学術集会, 2011年4月.
321.	森一博, 早渕康信 : 未熟児の左室機能の特徴 -speckle tracking法による左室内膜運動速度の検討-, 第22回日本心エコー図学会学術集会, 2011年4月.
322.	早渕康信, 阪田美穂, 大西達也, 渡辺典子, 香美祥二, 森一博 : 心室中隔を右室側と左室側に区別したストレイン解析は右室容量及び圧負荷の診断に有用である, 第22回日本心エコー図学会学術集会, 2011年4月.
323.	加地剛, 前田和寿, 須藤真功, 佐藤美紀, 中川竜二, 西條隆彦, 苛原稔, 早渕康信, 香美祥二 : 当院における胎児心エコー検査 -保険収載後1年を経て-, 第99回徳島周産期研究会, 2011年4月.
324.	加地剛, 前田和寿, 須藤真功, 佐藤美紀, 中川竜二, 西條隆彦, 苛原稔, 早渕康信, 香美祥二 : 当院における胎児心エコー検査 -保険収載後1年を経て-, 第99回徳島周産期研究会, 2011年4月.
325.	阪田美穂, 早渕康信, 井上美紀, 香美祥二 : カテーテル治療に成功した純型肺動脈閉鎖の一例, 第41回徳島心血管造影研究会, 2011年3月.
326.	阪田美穂, 早渕康信, 大西達也, 香美祥二 : 完全閉塞したBlalock-Taussig shunt(B-T shunt)に対してカテーテル治療で再開通を得た2乳児例, 第43回徳島心血管造影研究会, 2011年3月.
327.	阪田美穂, 早渕康信, 井上美紀, 大西達也, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 大動脈弁置換術後の遠隔期に上行大動脈瘤を発症した一例, 第25回日本小児循環器学会近畿・中国地方会, 2011年3月.
328.	阪田美穂, 早渕康信, 井上美紀, 大西達也, 香美祥二 : 大動脈置換術後の遠隔期に上行大動脈瘤を発症した1例, 第25回日本循環器学会近畿中四国地方会, 2011年3月.
329.	岡村和美, 渡邊浩良, 鈴江真史, 井上奈巳, 阪田美穂, 木下ゆき子, 近藤秀治, 早渕康信, 清水真樹, 玉木克佳, 香美祥二 : Fontan術後の肝過形成の2例, 第52回日本小児血液学会・第26回日本小児がん学会, 2010年12月.
330.	阪田美穂, 早渕康信, 大西達也, 苛原誠, 香美祥二, 北市隆, 北川哲也 : 完全閉塞したBlalock-Tauusig shunt (B-T shunt)に対してバルーン拡大術を施行した2乳児例, 第135回日本小児科学会徳島地方会, 2010年12月.
331.	Nabo Mohamed Helmy anal, 早渕康信, 阪田美穂, 大西達也, 香美祥二 : MDCT (multidetector-row CT) の部分肺静脈還流異常の診断に対する有用性, 第135回日本小児科学会徳島地方会, 2010年12月.
332.	大西達也, 早渕康信, 阪田美穂, 苛原誠, 香美祥二, 菅野幹雄, 北市隆, 北川哲也, 眞鍋哲也 : 著明に拡大した冠状動脈瘻の1例, 第135回日本小児科学会徳島地方会, 2010年12月.
333.	苛原誠, 早渕康信, 阪田美穂, 大西達也, 香美祥二, 森一博, 松岡優 : Afterload mismatchを呈した大動脈縮窄に対してバルーン拡大術を施行した2乳児例, 第135回日本小児科学会徳島地方会, 2010年12月.
334.	寺田知正, 早渕康信, 阪田美穂, 大西達也, 香美祥二, 中川竜二, 渡辺典子, 西條隆彦, 北市隆, 北川哲也, 吉本勉, 上田隆 : 28日間のECMO施行を要した肺動脈弁欠損症の1例, 第135回日本小児科学会徳島地方会, 2010年12月.
335.	鈴江真史, 中川竜二, 西條隆彦, 須賀健一, 渡辺典子, 阪田美穂, 早渕康信, 香美祥二 : 右大動脈弓に声帯麻痺を合併した1例, 第135回日本小児科学会徳島地方会, 2010年12月.
336.	阪田美穂, 早渕康信, 香美祥二 : バルーン拡大術によって狭窄血管のRecoilおよびSpasmsを生じ，ステント留置を必要とした腎血管性高血圧の1例, 第14回徳島小児循環器懇話会, 2010年10月.
337.	中山泰介, 北市隆, 神原保, 黒部裕嗣, 元木達夫, 菅野幹雄, 大西達也, 阪田美穂, 早渕康信, 北川哲也 : 右室流出路再建におけるBulging sinus patch/conduitの使用経験, 第6回四国小児循環器学研究会, 2010年10月.
338.	早渕康信, 井上美紀, 阪田美穂, 大西達也, 香美祥二 : 脳血流の盗血が疑われた鎖骨下動脈孤立症の1例, 第20回日本超音波医学会四国地方会, 2010年10月.
339.	宮崎達志, 多田羅勝義, 早渕康信, 香美祥二, 井上美紀, 森一博 : 左室後壁外側膜に輝度上昇が認められたDuchennne型筋ジストロフィー患者の局所心筋障害の評価, 第20回日本超音波医学会四国地方会, 2010年10月.
340.	笠井加奈, 加地剛, 東元あゆか, 須藤真功, 佐藤美紀, 中川竜二, 西條隆彦, 前田和寿, 苛原稔, 早渕康信 : 当センターにおける心室中隔欠損の胎児診断の現状, 第20回日本超音波医学会四国地方会, 2010年10月.
341.	宮崎達志, 多田羅勝義, 森一博, 阪田美穂, 井上美紀, 早渕康信, 香美祥二 : Duchenne型筋ジストロフィーの心筋障害における左室心筋の捩れ(Torsion)の異常, 第46回日本小児循環器学会学術集会, 2010年7月.
342.	宮崎達志, 多田羅勝義, 早渕康信, 香美祥二, 井上美紀, 森一博 : 左室後壁外側膜に輝度上昇が認められたDuchennne型筋ジストロフィー患者の局所心筋障害の評価, 第46回日本小児循環器学会学術集会, 2010年7月.
343.	井上美紀, 早渕康信, 阪田美穂, 渡辺典子, 香美祥二 : 左右両心室の拡張早期流入血流と弁輪部運動開始の時相解析の心室拡張不全に対する有用性 -Dual Dopplerを用いた検討-, 第46回日本小児循環器学会学術集会, 2010年7月.
344.	森一博, 早渕康信, 松岡優 : リアルタイム3次元エコーによる新生児早期の新たな左室機能評価 -左室局所壁運動および収縮同期性の日齢による変化-, 第46回日本小児循環器学会学術集会, 2010年7月.
345.	阪田美穂, 早渕康信, 井上美紀, 香美祥二 : 左房トラッキングを用いた左房容積曲線の一次微分曲線を用いた左房機能の解析, 第46回日本小児循環器学会学術集会, 2010年7月.
346.	早渕康信, 井上美紀, 阪田美穂, 渡辺典子, 香美祥二 : 先天性心疾患におけるHeart-type fatty acid-binding protein (H-FABP)測定の有用性に関する検討, 第46回日本小児循環器学会学術集会, 2010年7月.
347.	早渕康信, 井上美紀, 阪田美穂, 渡辺典子, 香美祥二 : 心臓カテーテル検査による血管造影では描出できず，multidetector-row CT (MDCT)でのみ診断できる小児循環器疾患の病態に関する考察, 第46回日本小児循環器学会学術集会, 2010年7月.
348.	北市隆, 吉田誉, 神原保, 黒部裕嗣, 元木達夫, 菅野幹雄, 阪田美穂, 井上美紀, 早渕康信, 香美祥二 : 新生児，乳児期早期開心根治術後の遠隔成績, 第53回関西胸部外科学会学術集会, 2010年6月.
349.	北市隆, 吉田誉, 神原保, 黒部裕嗣, 元木達夫, 菅野幹雄, 阪田美穂, 井上美紀, 早渕康信, 北川哲也 : 新生児，乳児期早期開心根治術後の遠隔成績, 関西胸部外科学会学術集会, 2010年6月.
350.	阪田美穂, 早渕康信, 井上美紀, 大西達也, 香美祥二, 菅野幹雄, 北市隆 : 大動脈弁置換術後遠隔期に著明な上行大動脈拡張をきたした一例, 第134回日本小児科学会徳島地方会, 2010年6月.
351.	大西達也, 早渕康信, 阪田美穂, 井上美紀, 苛原誠, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 心臓再同期療法が有効であった僧帽弁置換術後心不全の一例, 第134回日本小児科学会徳島地方会, 2010年6月.
352.	加地剛, 早渕康信, 須藤真功, 佐藤美紀, 中川竜二, 西條隆彦, 前田和寿, 苛原稔, 香美祥二 : 右上大静脈欠損を伴った左上大上静脈左房還流の胎児診断例, 第83回日本超音波医学会学術集会, 2010年5月.
353.	加地剛, 早渕康信, 須藤真功, 佐藤美紀, 中川竜二, 西條隆彦, 前田和寿, 苛原稔, 香美祥二 : 右上大静脈欠損を伴った左上大上静脈左房還流の胎児診断例, 第83回日本超音波医学会学術集会, 2010年5月.
354.	宮崎達志, 多田羅勝義, 阪田美穂, 井上美紀, 早渕康信, 香美祥二, 森一博 : Duchenne型筋ジストロフィーにおける左室心筋の捻れの異常, 第21回日本心エコー図学会学術集会, 2010年5月.
355.	早渕康信, 井上美紀, 阪田美穂, 香美祥二 : 先天性心疾患症例の肺血管床診断に対するminimun-intensity-projectionの有用性, 第113回日本小児科学会学術集会, 2010年4月.
356.	早渕康信 : 診断から10年を経過した特発性肺動脈性肺高血圧症の1男児例, 徳島肺高血圧症研究会2010, 2010年4月.
357.	岸夏子, 早渕康信, 井上美紀, 阪田美穂, 香美祥二 : 拘束型心筋症の1歳女児例, 第24回日本小児循環器学会近畿中四国地方会, 2010年2月.
358.	早渕康信 : 肺動脈血流の異常を指摘された新生児例, 第54回徳島心エコー図研究会, 2010年2月.
359.	阪田美穂, 早渕康信, 井上美紀, 香美祥二, 添木武 : 川崎病発症7年後にWPW症候群を呈し，15年後に発作性心房細動を呈した1例, 第15回四国心臓病フォーラム, 2009年10月.
360.	Manal Helmy Mohamed Nabo, 早渕康信, Miho Sakata, Miki Inoue, 香美祥二 : Stent-in-stenting が著効した完全大血管転換症Jatene術後肺動脈狭窄の1例, 第5回四国小児循環器研究会, 2009年10月.
361.	菅野幹雄, 北市隆, 吉田誉, 神原保, 黒部裕嗣, 元木達夫, 阪田美穂, 井上美紀, 早渕康信, 北川哲也 : 右室心尖部小切開による乳児期心尖部筋性VSDの閉鎖, 第62回日本胸部外科学会定期学術集会, 2009年10月.
362.	藤野修司, 早渕康信, 郷司彩, 阪田美穂, 井上美紀, 香美祥二 : 多発性肺動静脈瘻にコイル塞栓術を施行した遺伝性出血性毛細管拡張症の1例, 第20回徳島小児循環器談話会, 2009年10月.
363.	藤野修司, 早渕康信, 郷司彩, 阪田美穂, 井上美紀, 香美祥二 : 多発性肺動静脈瘻にコイル塞栓術を施行した遺伝性出血性毛細管拡張症の1例, 第40回徳島心・血管造影研究会, 2009年7月.
364.	元木達夫, 北市隆, 吉田誉, 神原保, 黒部裕嗣, 阪田澪穂, 井上美紀, 早渕康信, 北川哲也 : 右室心尖部小切開による乳児期心尖部筋性VSD の閉鎖, 第45回日本小児循環器学会学術集会(, 2009年7月.
365.	井上美紀, 早渕康信, 阪田美穂, 渡辺典子, 香美祥二 : 組織ドプラ法を用いた先天性心疾患における右室拡張機能評価の有用性に関する検討, 第45回日本小児循環器学会学術集会, 2009年7月.
366.	大西達也, 森一博, 早渕康信, 松岡優, 香美祥二 : Speckles tracking法を用いた小児左室長軸収縮の正常値の検討, 第45回日本小児循環器学会学術集会, 2009年7月.
367.	早渕康信, 井上美紀, 阪田美穂, 渡辺典子, 香美祥二 : MDCTを用いたSTS-minIP(sliding-thin-slab minimum intensity projection)は，肺血管抵抗の上昇・肺高血圧を検出できる, 第45回日本小児循環器学会学術集会, 2009年7月.
368.	北市隆, 吉田誉, 神原保, 元木達夫, 浦田将久, 阪田美穂, 井上美紀, 早渕康信, 北川哲也 : 小児期ペースメーカー治療 -心外膜電極による治療戦略-, 第45回日本小児循環器学会学術集会, 2009年7月.
369.	阪田美穂, 早渕康信, 井上美紀, 渡辺典子, 香美祥二 : 左房トラッキング法を用いた肺血流増加型先天性心疾患症例における左房機能・左室拡張能の解析, 第45回日本小児循環器学会学術集会, 2009年7月.
370.	宮崎達志, 多田羅勝義, 森一博, 井上美紀, 早渕康信, 香美祥二 : Duchenne型筋ジストロフィーにおける左室後壁外膜側のエコー輝度上昇の意義—スペックルトラッキング法による局所心筋ストレイン解析—, 第45回日本小児循環器学会学術集会, 2009年7月.
371.	渡辺典子, 早渕康信, 井上美紀, 阪田美穂, 香美祥二 : 「左右に伸展する大動脈弓(L-malposition + 右大動脈弓)は気管を圧迫し，呼吸不全を惹起する」, 第 27回西日本小児循環器HOT研究会, 2009年6月.
372.	早渕康信, 井上美紀, 阪田美穂, 渡辺典子, 香美祥二 : チアノーゼ性先天性心疾患乳幼児症例における体肺側副血管診断に対するMDCTの有用性, 第112回日本小児科学会学術集会, 2009年6月.
373.	宮崎達志, 多田羅勝義, 阪田美穂, 井上美紀, 早渕康信, 森一博, 香美祥二 : Duchenne型筋ジストロフィーにおける左室後壁外膜側のエコー輝度上昇の意義, 第20回日本心エコー学会学術集会, 2009年4月.
374.	井上美紀, 早渕康信, 阪田美穂, 香美祥二 : 三尖弁拡張早期流入血流速度と拡張早期三尖弁運動速度による先天性心疾患症例の右室拡張機能障害診断の有用性に関する検討, 第20回日本心エコー図学会学術集会, 2009年4月.
375.	北市隆, 神原保, 吉田誉, 黒部裕嗣, 元木達夫, 浦田将久, 阪田美穂, 井上美紀, 早渕康信, 北川哲也 : Fontan術後に動脈血酸素飽和度低下を来す因子の検討, 第109回日本外科学会定期学術集会, 2009年4月.
376.	阪田美穂, 早渕康信, 井上美紀, 近藤梨恵子, 香美祥二 : 動脈管にステント留置を施行した総動脈幹遺残，右大動脈弓，大動脈離断の新生児例, 第39回徳島心血管造影研究会, 2009年3月.
377.	郷司彩, 早渕康信, 井上美紀, 香美祥二 : 多発性肺動静脈漊にコイル塞栓術を施行した遺伝性出血性毛細血管拡張症の1例, 第23回日本小児循環器学会近畿・中四国地方会, 2009年1月.
378.	阪田美穂, 早渕康信, 井上美紀, 香美祥二 : 動脈管にステント留置を施行した総動脈幹遺残，右大動脈弓，大動脈離断(Van Praagh A4) の新生児例, 第20回日本Pediatric Interventional Cardiology 研究会, 2009年1月.
379.	北市隆, 吉田誉, 神原保, 黒部裕嗣, 元木達夫, 浦田将久, 阪田美穂, 井上美紀, 早渕康信, 北川哲也 : 乳児期早期のsymptomatic TOFの外科治療-PA with VSD, MAPCAs例も含めて-, 第61回日本胸部外科学会定期学術集会, 2008年10月.
380.	黒部裕嗣, 富永崇司, 元木達夫, 吉田誉, 神原保, 北市隆, 菅野幹雄, 早渕康信, 浦田将久, 川人智久, 長嶋光樹, 江川善康, 高浜洋介, 北川哲也 : 新生児期・乳児期早期の心臓手術に伴う胸腺摘除が免疫能に及ぼす影響, 第61回日本胸部外科学会定期学術集会, 2008年10月.
381.	吉田誉, 北市隆, 加納正志, 神原保, 黒部裕嗣, 元木達夫, 浦田将久, 早渕康信, 井上美紀, 北川哲也 : 様々なPLE発症要因と治療―Fontan術後PLE治療指針解明のために, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
382.	早渕康信, 井上美紀, 渡辺典子, 香美祥二 : Angiotensin IIによる新生仔および胎仔ラット大動脈平滑筋細胞のCa2+-activated K+ Channelに対する制御, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
383.	宮崎達志, 多田羅勝義, 井上美紀, 早渕康信, 香美祥二, 森一博 : Duchenne型筋ジストロフィ(DMD)の不整脈, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
384.	渡辺典子, 早渕康信, 井上美紀, 中川竜二, 西條隆彦, 北市隆, 北川哲也, 香美祥二 : 左右に伸展した大動脈弓は気管を圧迫する―Multidetector-row CT (MDCT)による正常例と大動脈弓走行異常症例の気管形態の観察―, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
385.	早渕康信, 井上美紀, 渡辺典子, 北市隆, 北川哲也, 香美祥二 : Multidetector-row CT (MDCT)によるチアノーゼ性先天性心疾患乳幼児症例における肺動脈径の計測, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
386.	井上美紀, 早渕康信, 渡辺典子, 香美祥二, 北市隆, 北川哲也 : 三尖弁拡張期早期流入血流と拡張早期三尖弁輪速度の比(E/E')による先天性心疾患症例の右室拡張機能障害診断の有用性に関する検討, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
387.	大西達也, 森一博, 早渕康信, 松岡優, 香美祥二 : 心エコーautomated functional imaging を用いた新しい小児心機能評価, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
388.	北市隆, 吉田誉, 神原保, 加納正志, 黒部裕嗣, 元木達夫, 浦田将久, 早渕康信, 井上美紀, 北川哲也 : MAPCAsを伴う乳児期複雑心疾患に対する外科治療の問題点, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
389.	北市隆, 吉田誉, 神原保, 加納正志, 黒部裕嗣, 元木達夫, 浦田将久, 早渕康信, 井上美紀, 北川哲也 : ファロー四徴症術後遠隔期における肺動脈弁の重要性, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
390.	宮崎達志, 多田羅勝義, 井上美紀, 早渕康信, 香美祥二, 森一博 : Duchenne型筋ジストロフィの左室局所ストレイン -2D tissue tracking法を用いた検討―, 第44回日本小児循環器学会総会・学術集会, 2008年7月.
391.	井上美紀, 早渕康信, 渡辺典子, 香美祥二 : 両側肺動脈絞扼術後に著明な体肺側副血管が認められた左心低形成症候群の1例, 第22回日本小児循環器学会近畿・中国四国地方会, 2008年1月.
392.	早渕康信 : 特発性肺動脈性肺高血圧症 -フローランを含めた加療ー, 肺動脈性肺高血圧症学術講演会, 2008年1月.
393.	早渕康信, 森一博, 渡辺典子, 来島敦史, 北市隆, 北川哲也, 香美祥二 : Multidetector-row CT(MDCT)を用いたexpanded polytetrafluoroethylene (ePTFE) グラフトの石灰化の診断と評価, 第43回日本小児循環器学会総会・学術総会, 2007年7月.
394.	宮崎達志, 多田羅勝義, 森一博, 早渕康信, 香美祥二, 井上美紀 : 心収縮時の「左室心筋のねじれ」は，どの部位でも均一か?, --- Tissue tracking法による検討 ---, 第43回日本小児循環器学会総会・学術集会, 2007年7月.
395.	宮崎達志, 早渕康信, 多田羅勝義, 森一博, 香美祥二, 井上美紀 : 進行性筋ジストロフィ(DMD)の左室心筋のねじれ-乳頭筋レベルでの検討-, 第43回日本小児循環器学会総会・学術集会, 2007年7月.
396.	早渕康信, 森一博, 鈴木光二郎, 渡辺典子, 香美祥二 : 動脈管開存症コイル塞栓術におけるmultidetector-row CT (MDCT)の有用性, 第110回日本小児科学会総会, 2007年4月.
397.	加地剛, 森一博, 鈴木光二郎, 須藤真功, 中山聡一郎, 三谷龍史, 中川竜二, 早渕康信, 前田和寿, 西條隆彦, 苛原稔, 香美祥二 : 総肺静脈還流異常(下心臓型)に静脈管無形成を伴った内臓錯位症候群の一例, 第18回日本心エコー図学会学術集会, 2007年4月.
398.	浦田将久, 北市隆, 加納正志, 来島敦史, 吉田誉, 増田裕, 北川哲也, 山野雅弘, 中西秀樹, 森一博, 早渕康信 : 小児開心術後縦隔炎に対しVACシステムが有用であった1例, 第15回徳島外科術後管理研究会, 2007年2月.
399.	渡辺典子, 早渕康信, 森一博, 鈴木光二郎, 香美祥二, 中川竜二, 西條隆彦, 嵩原裕夫, 北川哲也 : 大動脈走行異常による気管狭窄をきたしたVACTERL連合の一例, 第21回日本小児循環器学会近畿・中四国地方会, 2007年2月.
400.	早渕康信, 森一博, 鈴木光二郎, 渡辺典子, 香美祥二 : B-T シャント吻合部狭窄に対するバルーン血管形成術4日後に動脈瘤形成が確認された1例, 第18回日本Pediatric Interventional Cardiology 研究会, 2007年1月.
401.	早渕康信, 森一博, 鈴木光二郎, 渡辺典子, 香美祥二 : 動脈管開存症コイル塞栓術施行前後におけるmultidetector-row CT (MDCT)の有用性, 第18回日本Pediatric Interventional Cardiology 研究会, 2007年1月.
402.	吉田誉, 浦田将久, 来島敦史, 加納正志, 北市隆, 増田裕, 鈴木光二郎, 早渕康信, 森一博, 北川哲也 : Williams症候群の先天性大動脈弁上狭窄症に対する1手術例, 第89回日本循環器学会四国地方会, 2006年12月.
403.	阪田美穂, 森一博, 早渕康信, 鈴木光二郎, 香美祥二 : 多源性心房頻拍(MAT)の2例, 第1回四国小児循環器研究会, 2006年10月.
404.	早渕康信 : MDCTを用いたePTFEグラフト・パッチの石灰化の診断と評価, 第2回四国小児循環器研究会, 2006年10月.
405.	中川竜二, 西條隆彦, 阪田美穂, 早渕康信, 森一博, 香美祥二 : 胎児期に発見された新生児心室頻拍の3例, 第57回中国四国小児科学会, 2006年10月.
406.	森一博, 早渕康信, 鈴木光二郎, 阪田美穂, 香美祥二, 山田博胤, 馬場隆博 : Tissue tracking 法を用いた左室の「捻れ」の研究, 第25回小児循環動態研究会, 2006年10月.
407.	北市隆, 増田裕, 加納正志, 来島敦史, 黒部裕嗣, 森一博, 早渕康信, 鈴木光二郎, 北川哲也 : 小児における上室性頻拍に対する外科治療, 第42回日本小児循環器学会, 2006年7月.
408.	阪田美穂, 森一博, 早渕康信, 鈴木光二郎, 香美祥二 : 胎児期から観察された新生児心室性頻拍の3例, 第42回日本小児循環器学会総会・学術集会, 2006年7月.
409.	阪田美穂, 森一博, 早渕康信, 鈴木光二郎, 香美祥二, 馬場隆博 : Tissue tracking ehoccardiographyによる新生児三尖弁運動の解析, 第42回日本小児循環器学会総会・学術集会, 2006年7月.
410.	森一博, 早渕康信, 鈴木光二郎, 阪田美穂, 香美祥二, 多田羅勝義, 馬場隆博 : 進行性筋ジストロフィーにおける「左室の捻れ」の研究, 第42回日本小児循環器学会総会・学術集会, 2006年7月.
411.	早渕康信, 森一博, 鈴木光二郎, 阪田美穂, 香美祥二 : Angiotensin II は，PKCを介して intermediate-conductance Ca²⁺-activated K (IKca) channel を活性化する, 第42回日本小児循環器学会総会, 2006年7月.
412.	早渕康信, 森一博, 阪田美穂, 鈴木光二郎, 香美祥二 : MDCTを用いた仮想内視鏡による動脈管の形態的診断, 第42回日本小児循環器学会総会, 2006年7月.
413.	早渕康信 : 子供の心臓をMDCTで診る, 第17回徳島小児循環器懇話会, 2006年7月.
414.	加地剛, 森一博, 阪田美穂, 森根幹生, 中川竜二, 早渕康信, 前田和寿, 西條隆彦, 苛原稔, 香美祥二 : 妊娠14週から胎内経過を追うことができたEbstein奇形の1例, 第12回日本胎児心臓病研究会, 2006年2月.
415.	鈴木光二郎, 阪田美穂, 早渕康信, 森一博, 香美祥二 : 漏斗胸におる肺の圧迫によって生じた部分肺静脈還流異常の1例, 第20回日本小児循環器学会近畿中国四国地方会, 2006年2月.

その他・研究会:

1.	本間友佳子, 早渕康信, 菅野幹雄, 北市隆, 篠原健太, 秦広樹 : 心臓移植施設への搬送を2回試みたが，ともに始動段階で叶わなかった拡張型心筋症の1例, 第32回徳島小児循環器談話会, 2023年9月.
2.	本間友佳子, 早渕康信, 菅野幹雄, 北市隆, 秦広樹 : 一般講演「動脈管開存症にコイル塞栓術を施行した後にコイル感染と動脈瘤をきたした1例」, 第31回徳島小児循環器談話会, 2022年9月.
3.	佐藤宏紀, 須賀健一, 鈴江真史, 中川竜二, 郷司彩, 本間友佳子, 竹内竣亮, 田山貴広, 武井美貴子, 藤岡啓介, 小野朱美, 庄野実希, 七條光市, 近藤秀治, 早渕康信 : Ellis-van Creveld 症候群の1例, 第38階四国新生児医療研究会, 2021年6月. (キーワード) 先天性 (congenital)
4.	加地剛, 早渕康信, 中川竜二, 稲村昇, 苛原稔 : 胎児診断により出生直後の左腕頭動脈肺動脈起始から左腕頭動脈孤立症への経過を観察できた1例, 日本小児循環器学会雑誌, Vol.35, No.Suppl.1, 394, 2019年6月.
5.	本間友佳子, 早渕康信, 香美祥二 : 意識消失発作から診断されたカテコラミン誘発性多形性心室頻拍の(CPVT)の1男児例, 第151会日本小児科学会徳島地方会, 2018年12月.
6.	本間友佳子, 早渕康信, 香美祥二, 小野朱美 : ステント留置にside-cell拡大を加えて循環の安定を得た下心臓型総肺静脈還流異常の1新生児例, 第151会日本小児科学会徳島地方会, 2018年12月.
7.	本間友佳子, 早渕康信, 小野朱美, 香美祥二, 菅野幹雄, 北市隆, 北川哲也 : 両側下肺静脈閉塞に対して上下肺静脈間側副血管が発達し，フォンタン手術を施行し得た1例, 第150回日本小児科学会徳島地方会, 2018年6月.
8.	吉本夏実, 加地剛, 早渕康信, 今泉絢貴, 吉田あつ子, 米谷直人, 須賀健一, 中川竜二, 苛原稔 : 出生後に高度気管狭窄症状を呈した左肺動脈右肺動脈起始(PA sling)の一例, 超音波医学, Vol.45, 845, 2018年4月.
9.	小野朱美, 早渕康信, 香美祥二 : 内科的加療のみで軽快し，手術施行を回避できた重症僧帽弁狭窄兼閉鎖不全の1 乳児例, 第149回日本小児科学会徳島地方会, 2017年12月.
10.	岡田朝美, 田山貴広, 小野朱美, 小谷裕美子, 早渕康信, 香美祥二 : 母体糖尿病による心筋肥大と認識されていたPompe 病の1 乳児例, 第149回日本小児科学会徳島地方会, 2017年12月.
11.	小野朱美, 早渕康信, 市原裕子, 須賀健一, 中川竜二, 香美祥二 : 退院・在宅療養を目指し，心臓カテーテル治療・ステント留置を施行した18 トリソミーの2 例, 第148回日本小児科学会徳島地方会, 2017年6月.
12.	小野朱美, 早渕康信, 香美祥二 : 拘束性障害から肺高血圧を来したアントラサイクリン誘発性心筋症の1例, 第31回日本小児循環器学会近畿・中四国地方会, 2017年3月.
13.	阪田美穂, 早渕康信, 香美祥二, 森一博, 井上美紀, 添木武, 飛梅威, 松浦朋美, 坂東佐知子, 佐田政隆, 北市隆, 藤本鋭貴, 神原保, 黒部裕嗣, 北川哲也, 小野寺睦雄, 今中秀光, 西村匡司 : 経皮的心肺補助(PCPS)装着下にカテーテルアブレーションを施行し，救命し得た異所性接合部頻拍の1男児例, 第141回日本小児科学会徳島地方会, 2013年12月.
14.	近藤朝美, 早渕康信, 阪田美穂, 香美祥二, 木下肇, 中山泰介, 菅野幹雄, 北市隆, 北川哲也, 井上美紀, 森一博 : 左冠状動脈肺動脈起始症の1乳児例, 第141回日本小児科学会徳島地方会, 2013年12月.
15.	小野朱美, 早渕康信, 阪田美穂, 香美祥二, 井上美紀, 森一博 : 重篤な心不全で診断に至った特発性肺動脈性肺高血圧症の1男児例, 第141回日本小児科学会徳島地方会, 2013年12月.
16.	早渕康信, 阪田美穂, 近藤朝美, 香美祥二 : 左室心筋緻密化障害様の所見を呈した乳児白血病治療後心筋症, 第9回四国小児循環器研究会, 2013年11月.
17.	早渕康信, 阪田美穂, 香美祥二, 森一博, 井上美紀 : 肺高血圧を来した間質性肺炎の女児例, 第140回日本小児科学会徳島地方会, 2013年6月.
18.	阪田美穂, 早渕康信, 香美祥二 : 先天性QT延長症候群の母児例, 第140回日本小児科学会徳島地方会, 2013年6月.
19.	近藤朝美, 早渕康信, 阪田美穂, 渡邊浩良, 井上奈巳, 岡村和美, 香美祥二 : 左室心筋緻密化障害を呈した乳児白血病後アントラサイクリン誘発性心筋症の1例, 第140回日本小児科学会徳島地方会, 2013年6月.
20.	早渕康信, 阪田美穂, 香美祥二 : シンポジウム「成人先天性心疾患 Up to Date」先天性心疾患の画像診断-医療画像診断機器(modality)の比較と総合的診断-, 第24回日本心エコー図学会学術集会, 2013年4月.
21.	宮崎達志, 多田羅勝義, 早渕康信, 香美祥二, 井上美紀, 森一博 : Duchenne型筋ジストロフィーにおける左室後壁外膜側のエコー輝度上昇の意義-Strainによる局所心筋障害の評価-, 平成22年度筋ジストロフィーの臨床試験実施体制構築に関する研究川井班班会議, 2010年12月.
22.	早渕康信, 阪田美穂, 香美祥二, 森一博 : 診断から10年を経過した特発性肺動脈性肺高血圧症の1男児例, 徳島肺高血圧症研究会2010, 2010年4月.
23.	黒部裕嗣, 冨田修平, 早渕康信, 森一博, 北川哲也, 高浜洋介 : 新生児から乳児期における胸腺の全摘出あるいは部分切除が免疫系発生に与える影響, 第25回日本胸腺研究会, 2006年2月.

科学研究費補助金 (KAKEN Grants Database @ NII.ac.jp)

フォンタン循環症例の肺血管病変における血管外膜およびvasa vasorumの影響と治療応用 (研究課題/領域番号: 23K07226 )
肺高血圧における右室運動力学方程式と病理学所見の関連性の確立による診断・治療応用 (研究課題/領域番号: 19K08279 )
肺高血圧症における血管外膜およびvasa vasorumの役割解明と治療応用 (研究課題/領域番号: 16K10068 )
肺高血圧症における内皮由来過分極因子の役割解明と治療応用 (研究課題/領域番号: 25461621 )
肺高血圧症におけるカリウムチャネル制御の解明と治療応用 (研究課題/領域番号: 22591180 )
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特任教授 : 早渕康信

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特任教授 : 早渕 康信

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特任教授 : 早渕康信