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Tokushima UniversityGraduate School of Biomedical Sciences歯学域Oral ScienceBasic DentistryDepartment of Molecular Oral Physiology
Tokushima UniversityFaculty of DentistryCourse in DentistryBasic Oral SciencesMolecular Oral Physiology
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Research Activity

His Web Page

Field of Study

Molecular and Cellular Biology

Subject of Study

唾液腺における水・イオン輸送機構 (salivary gland, aquaporin)

Book / Paper

Academic Paper (Judged Full Paper):

1. Xiaoke Wang, Piaoyu Zhu, Shenya Xu, Yuting Liu, Yang Jin, Shali Yu, Haiyan Wei, Jinlong Li, Qinglin Zhang, Takahiro Hasegawa, Chenjuan Yao, Hiroshi Yoshimura, Qiyun Wu and Xinyuan Zhao :
Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway.,
The International Journal of Biochemistry & Cell Biology, Vol.114, 105561, 2019.
(DOI: 10.1016/j.biocel.2019.105561,   PubMed: 31228582)
2. Hiroshi Yoshimura, Sugai Tokio, Kato Nobuo, Tominaga Takashi, Tominaga Yoko, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Interplay between non-NMDA and NMDA receptor activation during oscillatory wave propagation: Analyses of caffeine-induced oscillations in the visual cortex of rats,
Neural Networks, Vol.79, 141-149, 2016.
(DOI: 10.1016/j.neunet.2016.03.012,   PubMed: 27136667)
3. Hiroshi Yoshimura, 川邊 真道, 須貝 外喜夫, 加藤 伸郎, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Influences of oral impairment on neural oscilltion and wave propagation in the neocortex of rats,
Neuroscience Research Suppl, Vol.Suppl, 2015.
4. Gang Chen, Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu, Hiroshi Yoshimura and Kazuo Hosoi :
Effects of isoproterenol on aquaporin 5 levels in the parotid gland of mice in vivo.,
American Journal of Physiology, Endocrinology and Metabolism, Vol.306, No.1, E100-E108, 2014.
(DOI: 10.1152/ajpendo.00317.2013,   PubMed: 24192288,   Elsevier: Scopus)
5. Hiroshi Yoshimura, Tokio Sugai, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Nobuo Kato :
Age-dependent emergence of caffeine-assisted voltage oscillations in the endopiriform nucleus of rats.,
Neuroscience Research, Vol.76, No.1-2, 16-21, 2013.
(DOI: 10.1016/j.neures.2013.02.010,   PubMed: 23517711,   Elsevier: Scopus)
6. Nunuk Purwanti, Mileva Ratko Karabasil, Shinsuke Matsuo, Gang Chen, Javkhlan Purevjav, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Induction of Sca-1 via activation of STAT3 system in the duct cells of the mouse submandibular gland by ligation of the main excretory duct,
American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.301, No.5, G814-G824, 2011.
(DOI: 10.1152/ajpgi.00408.2010,   PubMed: 21868636)
7. Purevjav Javkhlan, Yuka Hiroshima, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Jun-ichi Kido, Toshihiko Nagata and Kazuo Hosoi :
Lipopolysaccharide-mediated induction of calprotectin in the submandibular and parotid glands of mice,
Inflammation, Vol.34, No.6, 668-680, 2011.
(DOI: 10.1007/s10753-010-9277-1,   PubMed: 21125321)
8. Takahiro Hasegawa, Ahmad Azlina, Javkhlan Purevjav, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling,
American Journal of Physiology, Cell Physiology, Vol.301, No.3, C667-C678, 2011.
(DOI: 10.1152/ajpcell.00058.2011,   PubMed: 21633078)
9. Nunuk Purwanti, Daisuke Tsuji, Ahmad Azlina, Mileva Ratko Karabasil, Purevjav Javkhlan, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Kouji Itou and Kazuo Hosoi :
Induction of Sca-1 in the duct cells of the mouse submandibular gland by obstruction of the main excretory duct,
Journal of Oral Pathology & Medicine, Vol.40, No.8, 651-658, 2011.
(DOI: 10.1111/j.1600-0714.2011.01011.x,   PubMed: 21884259)
10. Mileva Ratko Karabasil, Takahiro Hasegawa, Ahmad Azlina, Nunuk Purwanti, Chenjuan Yao, Tetsuya Akamatsu, Shigemasa Tomioka and Kazuo Hosoi :
Effects of naturally occurring G103D point mutation of AQP5 on its water permeability, trafficking, and cellular localization in the submandibular gland of rats,
Biology of the Cell, Vol.103, No.2, 69-86, 2011.
(DOI: 10.1042/BC20100086,   PubMed: 21138418)
11. Ahmad Azlina, Purevjav Javkhlan, Yuka Hiroshima, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Roles of lysosomal proteolytic systems in AQP5 degradation in the submandibular gland of rats following chorda tympani parasympathetic denervation,
American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.299, No.5, G1106-G1117, 2010.
(DOI: 10.1152/ajpgi.00194.2010,   PubMed: 20689061)
12. Chenjuan Yao, Nunuk Purwanti, Mileva Ratko Karabasil, Ahmad Azlina, Javkhlan Purevjav, Takahiro Hasegawa, Tetsuya Akamatsu, Toru Hosoi, Koichiro Ozawa and Kazuo Hosoi :
Potential down-regulation of salivary gland AQP5 by LPS via cross-coupling of NF-κB and p-c-Jun/c-Fos,
The American Journal of Pathology, Vol.177, No.2, 724-734, 2010.
(DOI: 10.2353/ajpath.2010.090282,   PubMed: 20522648)
13. Y Ogushi, D Kitagawa, Takahiro Hasegawa, M Suzuki and S Tanaka :
Correlation between aquaporin and water permeability in response to vasotocin, hydrin and {beta}-adrenergic effectors in the ventral pelvic skin of the tree frog Hyla japonica.,
The Journal of Experimental Biology, Vol.213, No.2, 288-294, 2010.
(DOI: 10.1242/jeb.036871,   PubMed: 20038663)
14. Yuji Ogushi, Gen Akabane, Takahiro Hasegawa, Hiroshi Mochida, Manabu Matsuda, Masakazu Suzuki and Shigeyasu Tanaka :
Water adaptation strategy in anuran amphibians: molecular diversity of aquaporin.,
Endocrinology, Vol.151, No.1, 165-173, 2009.
(DOI: 10.1210/en.2009-0841,   PubMed: 19854867)
15. Mileva Ratko Karabasil, Takahiro Hasegawa, Ahmad Azlina, Nunuk Purwanti, Javkhlan Purevjav, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Trafficking of GFP-AQP5 chimeric proteins conferred with unphosphorylated amino acids at their PKA-target motif (152SRRTS) in MDCK-II cells,
The Journal of Medical Investigation : JMI, Vol.56, No.1, 2, 55-63, 2009.
(Tokushima University Institutional Repository: 111308,   DOI: 10.2152/jmi.56.55,   PubMed: 19262015)
16. Tetsuya Akamatsu, Ahmad Azlina, Nunuk Purwanti, Mileva Ratko Karabasil, Takahiro Hasegawa, Chenjuan Yao and Kazuo Hosoi :
Inhibition and transcriptional silencing of a subtilisin-like proprotein convertase, PACE4/SPC4, reduces the branching morphogenesis of and AQP5 expression in rat embryonic submandibular gland,
Developmental Biology, Vol.325, No.2, 434-443, 2009.
(DOI: 10.1016/j.ydbio.2008.10.015,   PubMed: 19013448)
17. Xuefei Li, Ahmad Azlina, Mileva Ratko Karabasil, Nunuk Purwanti, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic agonist,
American Journal of Physiology, Gastrointestinal and Liver Physiology, Vol.295, No.1, G112-G123, 2008.
(DOI: 10.1152/ajpgi.00359.2007,   PubMed: 18450949)
18. Gen Akabane, Yuji Ogushi, Takahiro Hasegawa, Masakazu Suzuki and Shigeyasu Tanaka :
Gene cloning and expression of an aquaporin (AQP-h3BL) in the basolateral membrane of water-permeable epithelial cells in osmoregulatory organs of the tree frog.,
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, Vol.292, No.6, R2340-R2351, 2007.
(DOI: 10.1152/ajpregu.00905.2006,   PubMed: 17332153)
19. Takahiro Hasegawa, Toshiyuki Matsuzaki, Yuki Tajika, Abduxukur Ablimit, Takeshi Suzuki, Takeo Aoki, Haruo Hagiwara and Kuniaki Takata :
Differential localization of aquaporin-2 and glucose transporter 4 in polarized MDCK cells.,
Histochemistry and Cell Biology, Vol.127, No.3, 233-241, 2007.
(DOI: 10.1007/s00418-006-0264-4,   PubMed: 17206499)
20. Shinya Yajima, Makoto Kubota, Takashi Nakakura, Takahiro Hasegawa, Nobuto Katagiri, Hideaki Tomura, Yuichi Sasayama and Masakazu Suzuki :
Cloning and expression of vacuolar proton-pumping ATPase subunits in the follicular epithelium of the bullfrog endolymphatic sac.,
Zoological Science, Vol.24, No.2, 147-157, 2007.
(DOI: 10.2108/zsj.24.147,   PubMed: 17409728,   Elsevier: Scopus)
21. Makoto Kubota, Takahiro Hasegawa, Takashi Nakakura, Haruna Tanii, Masakazu Suzuki and Shigeyasu Tanaka :
Molecular and cellular characterization of a new aquaporin, AQP-x5, specifically expressed in the small granular glands of Xenopus skin.,
The Journal of Experimental Biology, Vol.209, No.16, 3199-3208, 2006.
(DOI: 10.1242/jeb.02351,   PubMed: 16888067)
22. Akio Nakashima, Takahiro Hasegawa, Saori Mori, Masaru Ueno, Shigeyasu Tanaka, Takashi Ushimaru, Shusei Sato and Masahiro Uritani :
A starvation-specific serine protease gene, isp6+, is involved in both autophagy and sexual development in Schizosaccharomyces pombe.,
Current Genetics, Vol.49, No.6, 403-413, 2006.
(DOI: 10.1007/s00294-006-0067-0,   PubMed: 16550352)
23. Takahiro Hasegawa, Masakazu Suzuki and Shigeyasu Tanaka :
Immunocytochemical studies on translocation of phosphorylated aquaporin-h2 protein in granular cells of the frog urinary bladder before and after stimulation with vasotocin.,
Cell and Tissue Research, Vol.322, No.3, 407-415, 2005.
(DOI: 10.1007/s00441-005-0037-8,   PubMed: 16047161)
24. Shigeyasu Tanaka, Takahiro Hasegawa, Haruna Tanii and Masakazu Suzuki :
Immunocytochemical and phylogenetic distribution of aquaporins in the frog ventral skin and urinary bladder.,
Annals of the New York Academy of Sciences, Vol.1040, 483-485, 2005.
(DOI: 10.1196/annals.1327.097,   PubMed: 15891096)
25. Takahiro Hasegawa, Yuriko Sugawara, Masakazu Suzuki and Shigeyasu Tanaka :
Spatial and temporal expression of the ventral pelvic skin aquaporins during metamorphosis of the tree frog, Hyla japonica.,
The Journal of Membrane Biology, Vol.199, No.2, 119-126, 2004.
(DOI: 10.1007/s00232-004-0677-8,   PubMed: 15383922)
26. Takahiro Hasegawa, Haruna Tanii, Masakazu Suzuki and Shigeyasu Tanaka :
Regulation of water absorption in the frog skins by two vasotocin-dependent water-channel aquaporins, AQP-h2 and AQP-h3.,
Endocrinology, Vol.144, No.9, 4087-4096, 2003.
(DOI: 10.1210/en.2003-0418,   PubMed: 12933683)
27. Takashi Ushimaru, Takahiro Hasegawa, Toyoki Amano, Masao Katayama, Shigeyasu Tanaka and Hideo Tsuji :
Chloroplasts in seeds and dark-grown seedlings of lotus.,
Journal of Plant Physiology, Vol.160, No.3, 321-324, 2003.
(DOI: 10.1078/0176-1617-00964,   PubMed: 12749089)
28. Haruna Tanii, Takahiro Hasegawa, Noboru Hirakawa, Masakazu Suzuki and Shigeyasu Tanaka :
Molecular and cellular characterization of a water-channel protein, AQP-h3, specifically expressed in the frog ventral skin.,
The Journal of Membrane Biology, Vol.188, No.1, 43-53, 2002.
(DOI: 10.1007/s00232-001-0172-4,   PubMed: 12172646)

Academic Paper (Unrefereed Paper):

1. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
The Defense System of Oral Cavity: Lipopolysaccharide Induced Inflammatory Response in the Mice Salivary Gland,
BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book, 107, 2014.
2. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC4,
BIT's 1st Annual World Congress of Oral & Dental Medicine Conference Abstract Book, 59, 2014.
3. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
Enhanced ubiquitylation and downregulation of aquaporin-5 by ubiquitin ligases,
Journal of Oral Biosciences, Vol.Suppl., 204, 2014.
4. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
Expression of water channel AQP5 in regeneration model of salivary gland,
Journal of Oral Biosciences, Vol.Suppl., 204, 2014.
5. Minegishi Makoto, Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Induced expression of subtilisin-like proprotein convertase in regeneration model of salivary gland,
Journal of Oral Biosciences, Vol.Suppl., 138, 2014.

Review, Commentary:

1. Kazuo Hosoi, Chenjuan Yao, Takahiro Hasegawa, Hiroshi Yoshimura and Tetsuya Akamatsu :
Dynamics of Salivary Gland AQP5 under Normal and Pathologic Conditions,
International Journal of Molecular Sciences, Vol.21, No.4, 1182, Feb. 2020.
(Tokushima University Institutional Repository: 114575,   DOI: 10.3390/ijms21041182,   Elsevier: Scopus)
2. Kuniaki Takata, Toshiyuki Matsuzaki, Yuki Tajika, Abduxukur Ablimit and Takahiro Hasegawa :
Localization and trafficking of aquaporin 2 in the kidney.,
Histochemistry and Cell Biology, Vol.130, No.2, 197-209, Jun. 2008.
(DOI: 10.1007/s00418-008-0457-0,   PubMed: 18566824)
3. Masakazu Suzuki, Takahiro Hasegawa, Yuji Ogushi and Shigeyasu Tanaka :
Amphibian aquaporins and adaptation to terrestrial environments: a review.,
Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology, Vol.148, No.1, 72-81, Sep. 2007.
(DOI: 10.1016/j.cbpa.2006.12.021,   PubMed: 17270476)

Proceeding of International Conference:

1. Yuka Hiroshima, Mika Bandou, Takahiro Hasegawa, Yuji Inagaki and Chie Mihara-Wada :
Resistin release from neutrophils is induced by Porphyromonas gingivalis lipopolysaccharide.,
IADR (International Association of Dental Research) Barcelona, Spain, July 14-17, 2010,
2. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
Induced expression of a subtilisin-like proprotein convertase PACE4 in the regeneration model of rat submandibular gland.,
The 4th International Symposium on Salivary Glands in Honor of Niels Stensen, Okazaki (Japan), Nov. 2016.
3. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Sexual difference in the regeneration model of the rat submandibular gland.,
The 4th International Symposium on Salivary Glands in Honor of Niels Stensen, Okazaki (Japan), Nov. 2016.
4. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
Post-translational modifications of water channel aquaporin-5 in salivary gland cells, Oral Neuroscience 2016,
Oral Neuroscience 2016, Osaka, Oct. 2016.
5. Hiroshi Yoshimura, Tetsuya Akamatsu, Chenjuan Yao and Takahiro Hasegawa :
Synaptic plasticity in the brain -Roles of NMDA receptor- (Invited lecture at Nantong University),
Sep. 2016.
6. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
The Defense System of Oral Cavity: Lipopolysaccharide Induced Inflammatory Response in the Mice Salivary Gland,
Haikou, China, Nov. 2014.
7. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Salivary Gland Development, Differentiation, and Regeneration - Role of Subtilisin-like Proprotein Convertase PACE4/SPC4,
Haikou, China, Nov. 2014.
8. Mileva Ratko Karabasil, Kwartarini Murdiastuti, Nunuk Purwanti, Azlina Ahmad, Javkhlan Purevjav, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Effects of natural point mutation of rat aquaporin 5 expressed in vitro on its capacity of water permeability and membrane trafficking,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 398-400, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111488,   DOI: 10.2152/jmi.56.398,   PubMed: 20224238)
9. Purevjav Javkhlan, Yuka Hiroshima, Azlina Ahmad, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Jun-ichi Kido, Toshihiko Nagata and Kazuo Hosoi :
Induction of calprotectin mRNAs by lipopolysaccharide in the salivary gland of mice,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 287-289, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111354,   DOI: 10.2152/jmi.56.287,   PubMed: 20224205)
10. Azlina Ahmad, Xuefei Li, Purevjav Javkhlan, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Down-regulation of submandibular gland AQP5 following parasympathetic denervation in rats,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 273-276, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111348,   DOI: 10.2152/jmi.56.273,   PubMed: 20224200)
11. Nunuk Purwanti, Azlina Ahmad, Mileva Ratko Karabasil, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
Involvement of the IL-6/STAT3/Sca-1 system in proliferation of duct cells following duct ligation in the submandibular gland of mice,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 253-254, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111340,   DOI: 10.2152/jmi.56.253,   PubMed: 20224192)
12. Tetsuya Akamatsu, Azlina Ahmad, Purevjav Javkhlan, Takahiro Hasegawa, Chenjuan Yao and Kazuo Hosoi :
Salivary Gland Development: Its mediation by a subtilisin-like proprotein convertase, PACE4,
The Journal of Medical Investigation : JMI, Vol.56, No.Suppl, 241-246, Tokushima, Dec. 2009.
(Tokushima University Institutional Repository: 111337,   DOI: 10.2152/jmi.56.241,   PubMed: 20224189)

Proceeding of Domestic Conference:

1. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Involvment of subtilisin-like proprotein convertase PACE4 in regeneration of salivary gland,
第55回歯科基礎医学会(2013年9月19日-21日),
2. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Involvment of subtilisin-like proprotein convertase PACE4 in regeneration of salivary gland,
第55回歯科基礎医学会[2013年9月19日(金)-21日(日)],
3. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
唾液腺細胞におけるアクアポリン5の翻訳後修飾,
第53回歯科基礎医学会学術大会(2011年9月30日-10月2日)サテライトシンポジウムSS11,
4. Maeda Saori, Hiroshi Yoshimura, Miyaji Yuji, Hiroyuki Kanayama, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Increase in theta-band EEG activities under tasting chocolate with unmatched odor stimulation,
第41回日本神経科学大会, Jul. 2018.
5. 前田 さおり, Hiroshi Yoshimura, 宮地 ゆうじ, 金山 宏幸, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Theta band brain activity during checking the unmatched olfactory-taste information,
第95回日本生理学大会, Mar. 2018.
6. 前田 さおり, 宮地 裕司, 金山 宏幸, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
甘味とニオイのミスマッチが甘味認知に与える影響,
第69回日本生理学会中国・四国地方会, Oct. 2017.
7. Mio Hata, Tetsuya Akamatsu, Chenjuan Yao, 前田 さおり, 宮地 裕司, 金山 宏幸, Takahiro Hasegawa and Hiroshi Yoshimura :
唾液腺再生モデルにおける雌雄差の影響,
第69回日本生理学会中国・四国地方会, Oct. 2017.
8. 前田 さおり, Hiroshi Yoshimura, 宮地 ゆうじ, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Influences of Match/Mismatch of taste and odor on taste perception: An electroencephalogram frequency analysis study,
日本味と匂学会第51回大会, Sep. 2017.
9. Hiroshi Yoshimura, 須貝 外喜夫, 加藤 伸郎, 冨永 貴志, 冨永 洋子, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
カフェイン投与により誘発される視覚野オシレーション におけるnon-NMDA受容体とNMDA受容体の相互交錯的関与,
第40回日本神経科学大会, Jul. 2017.
10. Maeda Saori, Miyachi Yuki, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
Influences of olfactory stimulation on taste perception: An electroencephalogram frequency analysis study,
The 94th Annual Meeting of the Physiological Science of Japan, Mar. 2017.
11. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Sexual difference in regeneration of salivary gland,
第58回歯科基礎医学会学術大会, Aug. 2016.
12. Shimatani Tatsuya, Minegishi Makoto, Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Induction of a subtilisin-like proprotein convertase PACE4 in regeneration model of salivary gland Part II,
第58回歯科基礎医学会学術大会, Aug. 2016.
13. Hiroshi Yoshimura, 川邊 真道, 須貝 外喜夫, 加藤 伸郎, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
Influences of oral impairment on neural oscilltion and wave propagation in the neocortex of rats,
第38回日本神経科学大会, Jul. 2015.
14. Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and Hiroshi Yoshimura :
Expression of water channel AQP5 in regeneration model of salivary gland,
第56回歯科基礎医学会, Sep. 2014.
15. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
Enhanced ubiquitylation and downregulation of aquaporin-5 by ubiquitin ligases,
第56回歯科基礎医学会, Sep. 2014.
16. Minegishi Makoto, Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Induced expression of subtilisin-like proprotein convertase in regeneration model of salivary gland,
第56回歯科基礎医学会(福岡国際会議場/福岡県), Sep. 2014.
17. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
ヒト唾液腺HSG細胞における構成的なAQP5の取り込み,
第55回歯科基礎医学会[2013年9月19日(金)-21日(日)], Sep. 2013.
18. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Involvment of subtilisin-like proprotein convertase PACE4 in regeneration of salivary gland,
Journal of Oral Biosciences, Vol.55, No.Suppl., 199, Sep. 2013.
19. Hiroshi Yoshimura, 須貝 外喜夫, Chenjuan Yao, Tetsuya Akamatsu, Takahiro Hasegawa and 加藤 伸郎 :
ラット大脳皮質におけるnon-NMDA受容体活動に依存する20Hzオシレーション,
第36回日本神経科学大会[2013年6月20日(木)-23日(日)], Jun. 2013.
20. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Hiroshi Yoshimura :
ヒト唾液腺HSG細胞における構成的なAQP5の取り込み,
Journal of Oral Biosciences, Vol.55, No.Suppl., 199, 2013.
21. Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
唾液腺細胞におけるアクアポリン5の翻訳後修飾,
Journal of Oral Biosciences, Vol.53, No.Supplement, 104, Sep. 2011.
22. Purevjav Javkhlan, Yuka Hiroshima, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Toshihiko Nagata and Kazuo Hosoi :
Calprotectin expression in the mouse salivary gland: Induction by lipopolysaccharide,
第52回歯科基礎医学会(2010年9月20-22日), Sep. 2010.
23. Yuka Hiroshima, Purevjav Javkhlan, Ahmad Azlina, Takahiro Hasegawa, Tetsuya Akamatsu and Kazuo Hosoi :
Porphyromonas gingivalis由来LPSはヒト好中球からのレジスチンの遊離を促進する,
第52回歯科基礎医学会(2010年9月20-22日), Sep. 2010.
24. Takahiro Hasegawa, Ahmad Azlina, Purevjav Javkhlan, Yuka Hiroshima, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構,
第52回歯科基礎医学会(2010年9月20-22日), Sep. 2010.
25. Purevjav Javkhlan, Yuka Hiroshima, Ahmad Azlina, Takahiro Hasegawa, Chenjuan Yao, Tetsuya Akamatsu, Toshihiko Nagata and Kazuo Hosoi :
Calprotectin expression in the mouse salivary gland: Induction by lipopolysaccharide,
Journal of Oral Biosciences, Vol.52, No.supplement, 94, Sep. 2010.
26. Yuka Hiroshima, Javkhlan Purevjav, Ahmad Azlina, Takahiro Hasegawa, Tetsuya Akamatsu and Kazuo Hosoi :
Porphyromonas gingivalis由来LPSはヒト好中球からのレジスチンの遊離を促進する,
Journal of Oral Biosciences, Vol.52, No.supplement, 148, Sep. 2010.
27. Takahiro Hasegawa, Ahmad Azlina, Javkhlan Purevjav, Yuka Hiroshima, Chenjuan Yao, Tetsuya Akamatsu and Kazuo Hosoi :
唾液腺細胞におけるアクアポリン5リン酸化のシグナル伝達機構,
Journal of Oral Biosciences, Vol.52, No.supplement, 164, Sep. 2010.
28. プルワンティ ヌヌク, Daisuke Tsuji, アズリナ アハマド, カラバシル ミレーバ, Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu, Kouji Itou and Kazuo Hosoi :
Transient increase in IL-6 by duct ligation leading to continuous elevation of Sca-1, a stem cells marker, in the mouse submandibular gland,
第49回歯科基礎医学会学術大会, Aug. 2007.

Et cetera, Workshop:

1. Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu and Hiroshi Yoshimura :
マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構,
Journal of Oral Biosciences, Vol.54, No.Suppl., 153,
2. Shimatani Tatsuya, Minegishi Makoto, Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Induction of a subtilisin-like proprotein convertase PACE4 in regeneration model of salivary gland Part II,
Journal of Oral Biosciences, Vol.Suppl., 415, Aug. 2016.
3. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
Sexual difference in regeneration of salivary gland,
Journal of Oral Biosciences, Vol.Suppl., 451, Aug. 2016.
4. Tetsuya Akamatsu, Chenjuan Yao, Takahiro Hasegawa and Hiroshi Yoshimura :
唾液腺再生への subtilisin-like proprotein convertase PACE4の関与,
自然科学研究機構生理学研究所研究会「唾液腺形態形成研究会~機能解析から器官再生へ~」, Aug. 2014.
5. Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu and Hiroshi Yoshimura :
マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構,第54回歯科基礎医学会(郡山)2012年9月14-16日,
Sep. 2012.
6. Hiroshi Yoshimura, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
細胞内cAMP上昇が大脳皮質味覚野から口腔体性感覚野への信号伝播速度に与える影響,第54回歯科基礎医学会(郡山)2012年9月14-16日,
Sep. 2012.
7. Chenjuan Yao, Takahiro Hasegawa, Tetsuya Akamatsu and Hiroshi Yoshimura :
マウス耳下腺における水チャネルAQP5のイソプロテレノールによるdouwn-regulationの機構,
Journal of Oral Biosciences, Vol.54, No.Suppl., 153, Sep. 2012.
8. Hiroshi Yoshimura, Takahiro Hasegawa, Chenjuan Yao and Tetsuya Akamatsu :
細胞内cAMP上昇が大脳皮質味覚野から口腔体性感覚野への信号伝播速度に与える影響,
Journal of Oral Biosciences, Vol.54, No.Suppl., 131, Sep. 2012.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Molecular regulatory mechanisms for post-translational modifications of the water channel controlling salivary secretion. (Project/Area Number: 25462891 )
  • Physiological roles ofpost-translational modifications of water channel aquaporin-5 in the salivary glands. (Project/Area Number: 23792124 )
  • Elucidation of the molecular mechanism on the differentiation/maturation and functional expression of salivary acinar cell toward conquest of xerostomia. (Project/Area Number: 23592737 )
  • 病態時における外分泌腺型水チャネル、AQP5の発現と機能調節の分子機構 (Project/Area Number: 23592736 )
  • Regulation of posttranslational modification of water channel aquaporin-5 in the intracellular localization and trafficking (Project/Area Number: 21791806 )
  • Gontrol of intracellular trafficking of water channel aquaporin-2 (Project/Area Number: 19770054 )
  • Moecular meohanism of expression and regulation of the water channe1, aquapor in 5 in the exocrine gland (Project/Area Number: 18390493 )
  • Search by Researcher Number (50447273)