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Tokushima UniversityInstitute of Advanced Medical Sciences基幹研究部門
Tokushima UniversityGraduate School of MedicineMedicine酵素・プロテオミクス医学講座
Tokushima UniversityResearch ClustersResearch Clusters (Registered)2203006 宿主の炎症型マクロファージを標的とした抗炎症療法の開発
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Infectious Diseases of Children
Biochemistry

Subject of Study

Study of the molecular mechanism of influenza-associated encephalopathy (influenza-associated encephalopathy, mitochondria, adenosine triphosphate)
Development of ATP extraction and quantification kit from peripheral blood of patients (adenosine triphosphate, multiple organ failure) (Measurements of adenylate nucleotides (i.e., ATP, ADP) are used extensively to monitor energy stasis in broad range of cell types and tissues. For applications involving mammalian and other animal tissue, ATP are commonly extracted with chaotropic reagents particularly trichloroacetic acid (TCA) and perchloric acid (PCA). Physical methods for disintegration (boiling, sonic disintegration) have also used. As expected, these methods are suitable for measurements of cellular ATP, however these methods are inappropriate for histionic ATP because of the inefficiency of nucleotides extraction. Consequently, we have developed an integrated kit that includes software programs measuring tissue or total blood ATP. As the first step, we have evaluated the clinically usefulness of this system for determining blood ATP levels in patients with acute disease such as influenza-associated encephalopathy. It was found that various patients with severe disease have decreased blood ATP levels. It can be anticipated that in the abovementioned disease states, ATP measurement will become a valuable clinical parameter of great potential clinical importance.)

Book / Paper

Academic Paper (Judged Full Paper):

1. Dini Agriani Pasiana, Hironori Miyata, Junji Chida, Hideyuki Hara, Morikazu Imamura, Ryuichiro Atarashi and Suehiro Sakaguchi :
Central residues in prion protein PrPC are crucial for its conversion into the pathogenic isoform,
The Journal of Biological Chemistry, Vol.298, No.9, 102381, 2022.
(DOI: 10.1016/j.jbc.2022.102381,   PubMed: 35973512)
2. Keiji Uchiyama, Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Morikazu Imamura, Tsuyoshi Mori, Hanae Takatsuki, Ryuichiro Atarashi and Suehiro Sakaguchi :
Ethanolamine Is a New Anti-Prion Compound,
International Journal of Molecular Sciences, Vol.22, No.21, 11742, 2021.
(Tokushima University Institutional Repository: 117551,   DOI: 10.3390/ijms222111742,   PubMed: 34769172,   Elsevier: Scopus)
3. Hideyuki Hara, Junji Chida, Keiji Uchiyama, Dini Agriani Pasiana, Etsuhisa Takahashi, Hiroshi Kido and Suehiro Sakaguchi :
Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells.,
Scientific Reports, Vol.11, No.1, 10109, 2021.
(Tokushima University Institutional Repository: 117718,   DOI: 10.1038/s41598-021-89586-6,   PubMed: 33980968)
4. Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Keiji Uchiyama, Yutaka Kikuchi, Tomoko Naito, Yuichi Takahashi, Junji Yamamura, Hisashi Kuromatsu and Suehiro Sakaguchi :
Vaporized Hydrogen Peroxide and Ozone Gas Synergistically Reduce Prion Infectivity on Stainless Steel Wire.,
International Journal of Molecular Sciences, Vol.22, No.6, 3268, 2021.
(Tokushima University Institutional Repository: 116339,   DOI: 10.3390/ijms22063268,   PubMed: 33806892,   Elsevier: Scopus)
5. Keiji Uchiyama, Miyata Hironori, Yamaguchi Yoshitaka, Imamura Morikazu, Okazaki Mariya, Pasiana Dini Agriani, Junji Chida, Hideyuki Hara, Atarashi Ryuichiro, Watanabe Hitomi, Kondoh Gen and Suehiro Sakaguchi :
Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106.,
International Journal of Molecular Sciences, Vol.21, No.19, 7260, 2020.
(Tokushima University Institutional Repository: 115634,   DOI: 10.3390/ijms21197260,   PubMed: 33019549,   Elsevier: Scopus)
6. Junji Chida, Hideyuki Hara, Keiji Uchiyama, Etsuhisa Takahashi, Hironori Miyata, Hidetaka Kosako, Yukiko Tomioka, Toshihiro Ito, Hiroyuki Horiuchi, Haruo Matsuda, Hiroshi Kido and Suehiro Sakaguchi :
Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.,
PLoS Pathogens, Vol.16, No.8, e1008823, 2020.
(Tokushima University Institutional Repository: 115613,   DOI: 10.1371/journal.ppat.1008823,   PubMed: 32845931)
7. Suehiro Sakaguchi and Junji Chida :
Prion Protein Is a Novel Modulator of Influenza: Its Potential Implications for Anti-Influenza Therapeutics.,
Current Issues in Molecular Biology, Vol.37, 21-32, 2019.
(Tokushima University Institutional Repository: 115747,   DOI: 10.21775/cimb.037.021,   PubMed: 31814573,   Elsevier: Scopus)
8. Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Junji Chida, Keiji Uchiyama, Kentaro Masujin, Hitomi Watanabe, Gen Kondoh and Suehiro Sakaguchi :
The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region,
Molecular Neurobiology, Vol.57, 1203-1216, 2019.
(DOI: 10.1007/s12035-019-01804-5,   PubMed: 31707632,   Elsevier: Scopus)
9. Jun Oda, Yukioka Tetsu, Kazunari Azuma, Takao Arai, Junji Chida and Hiroshi Kido :
Endogenous genetic risk factor for serious heatstroke: the thermolabile phenotype of carnitine palmitoyltransferase II variant.,
Acute Medicine & Surgery, Vol.6, No.1, 25-29, 2018.
(DOI: 10.1002/ams2.373,   PubMed: 30651994)
10. Suehiro Sakaguchi and Junji Chida :
Roles of Prion Protein in Virus Infections.,
DNA and Cell Biology, Vol.37, No.10, 808-811, 2018.
(Tokushima University Institutional Repository: 112207,   DOI: 10.1089/dna.2018.4402,   PubMed: 30222366)
11. Junji Chida, Hideyuki Hara, Masashi Yano, Keiji Uchiyama, Rani Nandita Das, Etsuhisa Takahashi, Hironori Miyata, Yukiko Tomioka, Toshihiro Ito, Hiroshi Kido and Suehiro Sakaguchi :
Prion protein protects mice from lethal infection with influenza A viruses.,
PLoS Pathogens, Vol.14, No.5, e1007049, 2018.
(Tokushima University Institutional Repository: 112206,   DOI: 10.1371/journal.ppat.1007049,   PubMed: 29723291)
12. Junji Chida and Suehiro Sakaguchi :
Cellular prion protein-mediated protection against influenza A virus infection.,
Future Virology, Vol.14, No.1, 31-37, 2018.
(Tokushima University Institutional Repository: 113067,   DOI: 10.2217/fvl-2018-0146)
13. Hideyuki Hara, Miyata Hironori, Das Rani Nandita, Junji Chida, Yoshimochi Tatenobu, Keiji Uchiyama, Watanabe Hitomi, Kondoh Gen, Yokoyama Takashi and Suehiro Sakaguchi :
Prion Protein Devoid of the Octapeptide Repeat Region Delays BSE Pathogenesis in Mice.,
Journal of Virology, Vol.92, No.1, pii:e01368-17, 2018.
(Tokushima University Institutional Repository: 111465,   DOI: 10.1128/JVI.01368-17,   PubMed: 29046443,   CiNii: 1050845762396495104)
14. Keiji Uchiyama, Mitsuru Tomita, Masashi Yano, Junji Chida, Hideyuki Hara, Nandita Rani Das, Anders Nykjaer and Suehiro Sakaguchi :
Prions amplify through degradation of the VPS10P sorting receptor sortilin.,
PLoS Pathogens, Vol.13, No.6, e1006470, 2017.
(Tokushima University Institutional Repository: 110433,   DOI: 10.1371/journal.ppat.1006470,   PubMed: 28665987)
15. Das Rani Nandita, Miyata Hironori, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Watanabe Hitomi, Kondoh Gen and Suehiro Sakaguchi :
Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice.,
Archives of Virology, Vol.162, No.7, 1867-1876, 2017.
(Tokushima University Institutional Repository: 110119,   DOI: 10.1007/s00705-017-3295-3,   PubMed: 28255815,   Elsevier: Scopus)
16. Keiji Uchiyama, Miyata Hironori, Masashi Yano, Yoshitaka Yamaguti, Imamura Morikazu, Muramatsu Naomi, Das Rani Nandita, Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Mouse-Hamster Chimeric Prion Protein (PrP) Devoid of N-terminal Residues 23-88 Restores Susceptibility to 22L Prions, But Not to RML Prions in PrP-Knockout Mice.,
PLoS ONE, Vol.9, No.10, e109737, 2014.
(DOI: 10.1371/journal.pone.0109737,   PubMed: 25330286)
17. Yamane Kazuhiro, Indalao L. Irene, Junji Chida, Yamamoto Yoshikazu, Hanawa Masaaki and Hiroshi Kido :
Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza,
PLoS ONE, Vol.9, No.5, e98032, 2014.
(Tokushima University Institutional Repository: 106308,   DOI: 10.1371/journal.pone.0098032,   PubMed: 24865588,   Elsevier: Scopus)
18. Junji Chida, Rie Ono, Kazuhiko Yamane, Mineyoshi Hiyoshi, Masaji Nishimura, Mutsuo Onodera, Emiko Nakataki, Shichijo Koichi, Matsushita Masatomo and Hiroshi Kido :
Blood lactate/ATP ratio, as an alarm index and real-time biomarker in critical illness,
PLoS ONE, Vol.8, No.4, e60561, 2013.
(DOI: 10.1371/journal.pone.0060561,   PubMed: 23577122,   Elsevier: Scopus)
19. Etsuhisa Takahashi, Kosuke Kataoka, Irene L. Indalao, Keiko Konoha, Kazuyuki Fujii, Junji Chida, Dai Mizuno, Kohtaro Fujihashi and Hiroshi Kido :
Oral clarithromycin enhances airway IgA immunity through induction of IgA class switching recombination and B-cell activating factor of the tumor necrosis factor family molecule on mucosal dendritic cells in mice infected with influenza A virus,
Journal of Virology, Vol.86, No.20, 10924-1093, 2012.
(DOI: 10.1128/JVI.01207-12,   PubMed: 22896605,   Elsevier: Scopus)
20. Masaya Kubota, Junji Chida, Hideki Hoshino, Hiroshi Ozawa, Ayaka Koide, Hirohumi Kashii, Akiko Koyama, Yoko Mizuno, Ai Hoshino, Yamaguchi Miyoko, Dengbing Yao, Min Yao and Hiroshi Kido :
Thermolabile CPT II variants and low blood ATP levels are closely related to severity of acute encephalopathy in Japanese children,
Brain & Development, Vol.34, No.1, 20-27, 2012.
(DOI: 10.1016/j.braindev.2010.12.012,   PubMed: 21277129,   CiNii: 1570854176176565632)
21. Hiroshi Kido, Yuushi Okumura, Etsuhisa Takahashi, Haiyan Pan, Siye Wang, Dengbing Yao, Min Yao, Junji Chida and Mihiro Yano :
Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure,
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol.1824, No.1, 186-194, 2012.
(DOI: 10.1016/j.bbapap.2011.07.001,   PubMed: 21801859)
22. Min Yao, Dengbing Yao, Miyoko Yamaguchi, Junji Chida, Dengfu Yao and Hiroshi Kido :
Bezafibrate upregulates carnitine palmitoyltransferase II expression and promotes mitochondrial energy crisis dissipation in fibroblasts of patients with influenza-associated encephalopathy,
Molecular Genetics and Metabolism, Vol.104, No.3, 265-272, 2011.
(DOI: 10.1016/j.ymgme.2011.07.009,   PubMed: 21816645)
23. Dengbing Yao, Min Yao, Miyoko Yamaguchi, Junji Chida and Hiroshi Kido :
Characterization of compound missense mutation and deletion of carnitine palmitoyltransferase II in a patient with adenovirus-associated encephalopathy,
The Journal of Medical Investigation : JMI, Vol.58, No.3,4, 210-218, 2011.
(Tokushima University Institutional Repository: 83835,   DOI: 10.2152/jmi.58.210,   PubMed: 21921422)
24. Junji Chida, Siye Wang, Pan Hai-Yan, Le Quang Trong and Hiroshi Kido :
Influenza virus-cytokine-protease cycles are principal mechanisms of multi-organ failure in severe influenza and therapeutic approaches,
Influenza and Other Respiratory Viruses, Vol.5, No.1, 281-286, 2011.
25. Hai-Yan Pan, Hirotsugu Yamada, Junji Chida, Siye Wang, Mihiro Yano, Min Yao, Jianhua Zhu and Hiroshi Kido :
Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis,
Cardiovascular Research, Vol.89, No.3, 595-603, 2010.
(DOI: 10.1093/cvr/cvq358,   PubMed: 21084314)
26. Siye Wang, Le Quang Trong, Kurihara Naoki, Junji Chida, Youssouf Cisse, Mihiro Yano and Hiroshi Kido :
Influenza Virus Cytokine Protease Cycle in the Pathogenesis of Vascular Hyperpermeability in Severe Influenza,
The Journal of Infectious Diseases, Vol.202, No.7, 991-1001, 2010.
(DOI: 10.1086/656044,   PubMed: 20731583)
27. Etsuhisa Takahashi, Kosuke Kataoka, Kazuyuki Fujii, Junji Chida, Dai Mizuno, Makoto Fukui, Hiro-O Ito, Kohtaro Fujihashi and Hiroshi Kido :
Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus.,
Microbes and Infection, Vol.12, No.10, 778-783, 2010.
(DOI: 10.1016/j.micinf.2010.04.013,   PubMed: 20452454)
28. Siye Wang, Le Quang Trong, Junji Chida, Youssouf Cisse, Mihiro Yano and Hiroshi Kido :
Meckanisms of matrix metallo protease-9 wuregulation and tissue desfruction in rarious organs in influenza A virus infection,
The Journal of Medical Investigation : JMI, Vol.57, No.1,2, 26-34, 2010.
(DOI: 10.2152/jmi.57.26,   PubMed: 20299740)
29. Sawabuchi Takako, Suzuki Satoshi, Isase Kazuhiro, Ito Chika, Dai Mizuno, Todari Hajime, Watanabe Isamu, Talukder R. Sadiqur, Junji Chida and Hiroshi Kido :
Boost of mucosal secretory immunoglobulin A response by clarithromycin in paediatric influenza,
Respirology, Vol.14, No.8, 1173-1179, 2009.
(DOI: 10.1111/j.1440-1843.2009.01639.x,   PubMed: 19909463)
30. Hiroshi Kido, Yuushi Okumura, Etsuhisa Takahashi, HY Pan, Siye Wang, Junji Chida, Le Trong Quang and Mihiro Yano :
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.,
Journal of Molecular and Genetic Medicine, Vol.3, No.1, 167-175, 2009.
(PubMed: 19565019)
31. Dengbing Yao, Hiroshi Mizuguchi, Miyoko Yamaguchi, Hiroshi Yamada, Junji Chida, Koji Shikata and Hiroshi Kido :
Thermal instability of compound variants of carnitine palmitoyltransferase II and impaired mitochondrial fuel utilization in influenza-associated encephalopathy.,
Human Mutation, Vol.29, No.5, 718-727, 2008.
(DOI: 10.1002/humu.20717,   PubMed: 18306170)
32. Junji Chida, Aiko Amagai, Masashi Tanaka and Yasuo Maeda :
Establishment of a new method for precisely determining the functions of individual mitochondrial genes, using Dictyostelium cells.,
BMC Genetics, Vol.9, 25, 2008.
(DOI: 10.1186/1471-2156-9-25,   PubMed: 18366713)
33. Junji Chida, Hitomi Yamaguchi, Aiko Amagai and Yasuo Maeda :
The necessity of mitochondrial genome DNA for normal developmental of Dictyostelium cells.,
Journal of Cell Science, Vol.117, No.Pt 15, 3141-3152, 2004.
(DOI: 10.1242/jcs.01140,   PubMed: 15226392)
34. Kou-ichi Hosoya, Aiko Amagai, Junji Chida and Yasuo Maeda :
Unique behavior and function of the mitochondrial ribosomal protein S4 (RPS4) in early Dictyostelium development.,
Zoological Science, Vol.20, No.12, 1455-1465, 2003.
(DOI: 10.2108/zsj.20.1455,   PubMed: 14709810)

Academic Paper (Unrefereed Paper):

1. Junji Chida and Hiroshi Kido :
Extraction and quantification of adenosine triphosphate in mammalian tissues and cells.,
Methods in Molecular Biology, Vol.1098, 21-32, 2014.
(DOI: 10.1007/978-1-62703-718-1_2,   PubMed: 24166365,   Elsevier: Scopus)
2. Hiroshi Kido and Junji Chida :
Pathogenesis of influenza-associated encephalopathy, --- CPT2 SNP as a phathogenetic risk factor ---,
Journal of Clinical and Experimental Medicine, Vol.241, No.1, 23-28, 2012.
(CiNii: 1524232505307507072)

Academic Letter:

1. Hiroshi Kido, Dengbing Yao, Junji Chida, Youssouf Cisse and Yao Min :
Pathogenesis of influenza-associated encephalopathy: disorder of fatty acid metabolism in mitochondria and increased membrane permeability in endothelial cells,
The Medical Frontline, Vol.65, No.1, 52-60, 2010.
(CiNii: 1522543654897644800)
2. Junji Chida, Aiko Amagai and Yasuo Maeda :
Validity of Dictyostelium mitochondrial DNA-less cells for elucidating the regulatory mechanisms of development.,
Journal of Plant Research, Vol.116, 149-150, 2003.

Review, Commentary:

1. Junji Chida, Hiroshi Kido and Suehiro Sakaguchi :
宿主因子を標的にした新たなインフルエンザ治療の試み,
BIO Clinica, Vol.256, No.33, 52-55, Feb. 2018.
2. Hiroshi Kido and Junji Chida :
インフルエンザ脳症への新たな対応策は?,
インフルエンザの最新知見 Q & A 2012, 171-172, May 2012.
3. 水野 葉子, 久保田 雅也, 柏井 洋文, 宮田 理英, 田沼 直之, 林 雅晴, Junji Chida, 山口 美代子, Yao Dengbing, Yao Min and Hiroshi Kido :
Carnitine palmitoyltransferase II (CPT II) の熱不安定性遺伝子多型を持った急性脳症の1例,
Japanese Journal of Pediatrics, Vol.65, No.5, 1057-1062, 2012.
4. Hiroshi Kido and Junji Chida :
インフルエンザ脳症の発症機序ー遺伝子多型が解き明かす発症基盤ー,
Influenza, Vol.44, No.12(3), 225-232, Oct. 2011.
(CiNii: 1520291856148604032)
5. Hiroshi Kido, Junji Chida, Yao Min, Dengbing Yao and 山根 一彦 :
遺伝子多型解析が解き明かすインフルエンザ脳症と多臓器不全,
Experimental Medicine, Vol.28, No.18, 2927-2933, Nov. 2010.
6. Hiroshi Kido and Junji Chida :
インフルエンザ感染の重症化機序,
Neuroinfection, Vol.15, No.1, 66-73, Sep. 2010.
7. Hiroshi Kido, Junji Chida, Min Yao and Siye Wang :
Mechanisms of multi-organ failure in severe influemza,
Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.68, No.8, 1565-1573, Aug. 2010.
(PubMed: 20715496,   CiNii: 1521136280984508800)
8. Hiroshi Kido, Junji Chida, Yao Min and Wang Siye :
最近のインフルエンザ治療の動向とクラリスロマイシン投与の意義,
大阪府内科医会誌, Vol.19, No.1, 47-54, Apr. 2010.
9. Junji Chida, Dengbing Yao, Siye Wang, Miyoko Yamaguchi and Hiroshi Kido :
インフルエンザの重症化をめぐって,
The Japanese Journal of Antibiotics, (in-press), 2009.
10. Hiroshi Kido, Dai Mizuno, Tunetomo Takei, Maki Nisino, Junji Chida and Cisse Youssof :
インフルエンザ経鼻ワクチン -肺サーファクタント粘膜免疫-,
小児科, Vol.48, No.12, 1837-1844, Nov. 2007.
11. Hiroshi Kido, Dai Mizuno, Tunetomo Takei, Maki Nisino, Junji Chida and Youssouf Cisse :
インフルエンザ経鼻ワクチン,
Pediatrics of Japan, Vol.48, No.12, 1837-1844, Nov. 2007.
12. Hiroshi Kido, Dengbing Yao, Le Trong Quang, Mariko Tsukane and Junji Chida :
Analysis of SNPs and enzymatic disorder in the patients of influenza-associated encephalopathy., --- Disorder of fatty acid metabolism in mitochondria induced by high fever. ---,
Nihon Rinsho. Japanese Journal of Clinical Medicine, Vol.64, No.10, 101-109, Oct. 2007.
13. Hiroshi Kido, Dengbing Yao, Le Trong Quang, Junji Chida, Yuushi Okumura and Hiroshi Yamada :
インフルエンザ感染,
Antibiotics and Chemotherapy, Vol.23, No.7, 101-109, Jul. 2007.
14. Hiroshi Kido, Dengbing Yao, Le Quang Trong, Junji Chida, Yuushi Okumura and Hiroshi Yamada :
インフルエンザ感染,インフルエンザ脳症の制圧に向けて,科学治療の領域,
Antibiotics & Chemotherapy, Vol.23, No.7, 101-109, 2007.

Proceeding of International Conference:

1. Etsuhisa Takahashi, HY Pan, IL Indalao, Junji Chida and Hiroshi Kido :
TRYPSIN KOCKDOWN AND TRYPSIN INHIBITOR ADMINISTRATION SUPPRESSED INFLUENZA VIRAL REPLICATION AND VIRUS-INDUCES MYOCARDITIS IN THE HEARTS AND CARDIOMYOBLAST CELLS,
7th General Meeting of the International Proteolisis, San Diego, Oct. 2011.
2. Hiroshi Kido, Junji Chida, Siye Wang, Hai-Yan Pan and Min Yao :
Influenza-Cytokine-Protease Cycle in the pathogenesis of vascular hyperpermeability in severe influenza and its possible treatments,
BMB2010, Dec. 2010.
3. Junji Chida, Siye Wang, Haiyan Pan, Min Yao, Dengbing Yao, Kazuhiko Yamane and Hiroshi Kido :
Influenza virus-cytokine-protease cycle and mitochondrial ATP depletion are the principal mechanisms of multi-organ failure in severe influenza and therapeutic approaches,
Options for the Control of Influenza VII, China, Hong Kong, Sep. 2010.
4. Junji Chida, Siye Wang, Hai-Yan Pan, Min Yao, Dengbing Yao, Kazuhiko Yamane and Hiroshi Kido :
Influenza virus-cytokine-protease cycle and mitochondrial ATP depletion are the principal mechanisms of multi-organ failure in severe influenza and therapeutic approaches.,
Oprions for the Control of Influenza, Hong Kong, Sep. 2010.
5. Junji Chida, Siye Wang, Tadashi Enomoto, Yuushi Ohnishi and Hiroshi Kido :
Up-regulations of ectopic pancreatic trypsin mRNAs by influenza virus infection and pathological role of them in multi-organ failure after virus infection.,
5th International Proteolysis Society, Patras, Oct. 2007.
6. Junji Chida, Masashi Tanaka, Aiko Amagai and Yasuo Maeda :
A new approach to disrupt certain mitochondrial genes in Dictyostelium cells.,
International Conference on Mitochondria and Life 2005, Tokyo, Dec. 2005.
7. Junji Chida, Masashi Tanaka, Aiko Amagai and Yasuo Maeda :
Unexpected and novel functions of mitochondria, revealed by Dictyostelium cells.,
International Conference on Mitochondria and Life 2005, Tokyo, Dec. 2005.
8. Junji Chida, Masashi Tanaka, Aiko Amagai and Yasuo Maeda :
Establishment of a system for elucidating precisely the function of individual mitochondrial genes.,
18th Annual International Dictyostelium Conference, Lyon, Aug. 2005.
9. Junji Chida, Hitomi Yamaguchi, Aiko Amagai and Yasuo Maeda :
Contributions of mitochondrial DNA to cell differentiation and pattern formation in Dictyostelium development.,
16th Annual International Dictyostelium Conference, Melbourne, Jul. 2003.
10. Chad Shaw, Nancy Van Driessche, Miroslava Ibarra, Sujata Sharma, Engi Okyay, Takahiro Morio, Mariko Katoh, Hideko Urushihara, Yoshimasa Tanaka, Junji Chida, Aiko Amagai, Yasuo Maeda, Dana Mahadeo, David Cotter, Adam Kusupa and Gad Shaulsky :
Beyond development: transcriptional profiling of the Dictyostelium cell cycle, spore germination and de-differentiation.,
15th Annual International Dictyostelium Conference, Sicilla, Sep. 2002.

Proceeding of Domestic Conference:

1. Junji Chida, Eiji Hara, Mayuko Shimizu, Koichi Tsuneyama and Suehiro Sakaguchi :
Anti-prion antibody treatment attenuates liver inflammation and fibrosis in experimental non-alcoholic steatohepatitis mouse modelAnti-prion antibody treatment attenuates liver inflammation and fibrosis in experimental non-alcoholic steatohepatitis mouse model,
2. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
ネクロトーシスをトリガーとした異常型プリオン蛋白質産生の分子機構,
第45回日本分子生物学会年会, Nov. 2022.
3. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
インフルエンザウイルス感染は神経細胞において感染性プリオンの産生を引き起こす,
第44回日本分子生物学会年会, Dec. 2021.
4. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
プリオン蛋白質はインフルエンザ A ウイルス感染による重症化を軽減する,
第42回日本分子生物学会年会, Dec. 2019.
5. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
ウイルス感染を用いたプリオン病発症機構の解明,
第42回日本分子生物学会年会, Dec. 2019.
6. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
Influenza virus infection triggers de novo generation of prions in neuronal cells,
第41回日本分子生物学会年会, Nov. 2018.
7. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Prion protein provides a protection against influenza A virus infection,
第66回日本ウイルス学会学術集会, Oct. 2018.
8. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
Prion protein protects mice from lethal infection with Influenza A virues,
2017年度生命科学系学会合同年次大会 (ConBio2017) 第 40回日本分子生物学会年会/第90回日本 生化学会大会, Dec. 2017.
9. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
Prion-infected neuroblastoma cells are resistant to influenza virus.,
2017年度生命科学系学会合同年次大会 (ConBio2017) 第 40回日本分子生物学会年会/第90回日本 生化学会大会, Dec. 2017.
10. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
蛋白質凝集体「プリオン」による抗インフルエンザウイルス活性機構の解明,
第39回日本分子生物学会年会, Dec. 2016.
11. Hideyuki Hara, Junji Chida and Suehiro Sakaguchi :
蛋白質凝集体「プリオン」による抗インフルエンザ活性の発見,
第38回日本分子生物学会年会 第88回日本生化学会大会合同大会, Dec. 2015.
12. Mutsuo Onodera, Emiko Nakataki, Junji Chida, Hideaki Imanaka, Hiroshi Kido and Masaji Nishimura :
ICU入室患者における末梢血アデノシン三リン酸(ATP)と転帰との関係,
第39回日本集中治療医学会総会, Feb. 2012.
13. Rie Ono, Masaji Nishimura, Jun Oto, Hideaki Imanaka, Junji Chida and Hiroshi Kido :
重症患者の末梢血ATP乳酸値比,
日本麻酔科学会第58回学術集会,神戸, May 2011.
14. Min Yao, Junji Chida, Hiyan Pan, Siye Wang and Hiroshi Kido :
Effect of Bezafibrate on mitochondrial energy crisis in the fibroblast of severe influenza-associated encephalopathy patients,
第33回日本分子生物学会年会 第83回 日本生化学会大会合同大会,, Dec. 2010.
15. Junji Chida, Min Yao, Dengbing Yao, Miyoko Yamaguchi and Hiroshi Kido :
Pathogenesis of impaired systemic energy metabolism by severe influenza virus infection Analysis using mouse models of defect in mitochondrial -oxidation of long-chain fatty acids,
第33回日本分子生物学会年会 第83回 日本生化学会大会合同大会,, Dec. 2010.
16. Hiroshi Kido, Junji Chida, Siye Wang, Hiyan Pan and Min Yao :
Influenza-Cytokine-Protease Cycle in the pathogenesis of vascular hyper-permeability in severe influenza and its possible treatment,
第33回日本分子生物学会年会 第83回 日本生化学会大会合同大会,, Dec. 2010.
17. Yao Min, Etsuhisa Takahashi, Pan Haiyan, Junji Chida and Hiroshi Kido :
A Type II Transmembrane Serine Protease Serase-1B, a New Splice Variant of Polyserase-1/TMPRSS9, Plays a Role in Adipogenesis.,
第83回日本生化学会大会, Dec. 2010.
18. Hai-Yan Pan, Junji Chida and Hiroshi Kido :
Up-regulation of ectopic trypsin in myocardium triggers acute myocarditis in severe influenza,
Seikagaku, Dec. 2010.
19. Min Yao, Junji Chida, Hai-Yan Pan, Siye Wang and Hiroshi Kido :
Effect of Bezafibrate on mitochondrial energy crisis in the fibroblast of severe influenza-associated encephalopathy patients,
Seikagaku, Dec. 2010.
20. Junji Chida, Min Yao, Dengbing Yao, Miyoko Yamaguchi and Hiroshi Kido :
Pathogenesis of impaired systemic energy metabolism by severe influenza virus infection Analysis using mouse models of defect in mitochondrial -oxidation of long-chain fatty acids-,
Seikagaku, Dec. 2010.
21. Hiroshi Kido, Junji Chida, Siye Wang, Hai-Yan Pan and Min Yao :
Influenza-Cytokine-Protease Cycle in the pathogenesis of vascular hyper-permeability in severe influenza and its possible treatment.,
Seikagaku, Dec. 2010.
22. Junji Chida, Siye Wang, Dengbing Yao, Min Yao, Miyoko Yamaguchi and Hiroshi Kido :
インフルエンザ脳症の発症メカニズムの酵素学的な解析,
温熱生理研究会, Sep. 2010.
23. Junji Chida :
インフルエンザ脳症のリスク診断を可能にする DNA チップの開発と患者の重症度をモニターする末梢血の ATP 測定システムの開発,
第9回 次世代医療システム産業化フォーラム, Dec. 2008.
24. Junji Chida, Tadashi Enomoto, Hiroki Arase and Hiroshi Kido :
Molecular pathogenesis and multiplicity of influenza virus A/WSN/33 in plasminogen deficient mice.,
第81回 日本生化学会大会, Dec. 2008.
25. Yuuji Onishi, Junji Chida, Youssouf Cisse and Hiroshi Kido :
Molecular mechanism of the decrease in ATP levels by influenza virus infection.,
第81回 日本生化学会大会, Dec. 2008.
26. Min Yao, Dengbing Yao, Miyoko Yamaguchi, Junji Chida and Hiroshi Kido :
Effect of bezafibrate on mitochondrial energy crisis in the fibroblasts of severe influenza-associated encephalopathy patients.,
第81回 日本生化学会大会, Dec. 2008.
27. Junji Chida, Talukder R Sadiqur, Yuushi Okumura and Hiroshi Kido :
インフルエンザ感染後に発現誘導されるトリプシン遺伝子群の転写制御ネットワーク,
第13回 病態と治療におけるプロテアーゼとインヒビター学会, Aug. 2008.
28. Arase Hiroki, Junji Chida, Tadashi Enomoto and Hiroshi Kido :
インフルエンザウイルスの活性化・増殖仮説のプラスミノーゲン KO マウスを用いた検証,
第13回 病態と治療におけるプロテアーゼとインヒビター学会, Aug. 2008.
29. Junji Chida, Dengbing Yao, Siye Wang, Miyoko Yamaguchi and Hiroshi Kido :
インフルエンザ脳症発症の分子機序の解明,
第15回 マクロライド新作用研究会, Jul. 2008.
30. Tadashi Enomoto, Hiroshi Yamada, Junji Chida, Siye Wang and Hiroshi Kido :
Mechanism of augmentation of symptomatic of influenza virus infection by antipyretic, diclophenac.,
第30回 日本分子生物学会,第80回 日本生化学会大会, Dec. 2007.
31. Junji Chida, Tadashi Enomoto, Yuushi Ohnishi, Mariam Nasreen and Hiroshi Kido :
Down-regulation of mitochondrial related-genes by influenza virus infection and pathological role of them in multi-organ failure after virus infection.,
第30回 日本分子生物学会年会,第80回 日本生化学会大会, Dec. 2007.
32. Junji Chida, Tadashi Enomoto, Miyoko Yamaguchi, Kiyotaka Okada and Hiroshi Kido :
プラスミノーゲン欠損マウスを用いたインフルエンザウイルスの増殖機構の解析,
第12回 病態と治療におけるプロテアーゼとインヒビター学会, Jun. 2007.
33. Yasuo Maeda, Junji Chida, Kaori Hirata, Tuyoshi Morita, Hitomi Yamaguchi and Aiko Amagai :
細胞性粘菌を用いた研究で明らかになったミトコンドリアの多彩な機能,
第18回 日本植物支部大会, Dec. 2005.
34. Junji Chida, Masashi Tanaka, Aiko Amagai and Yasuo Maeda :
MtDNA による増殖/分化の統御,
第69回 日本植物学会大会, Sep. 2005.
35. Junji Chida, Masashi Tanaka, Aiko Amagai and Yasuo Maeda :
粘菌細胞の分化・パターン形成におけるミトコンドリア遺伝子 (mtDNA) の重要性,
第38回 日本発生生物学会大会, Jun. 2005.
36. Junji Chida, Masashi Tanaka, Aiko Amagai and Yasuo Maeda :
ミトコンドリア遺伝子の機能解析を実現するシステムの確立,
第17回 日本植物支部大会, Dec. 2004.
37. Junji Chida, Hitomi Yamaguchi, Aiko Amagai and Yasuo Maeda :
細胞性粘菌の分化統御面における mtDNA の多面的な機能,
第16回 日本植物支部大会, Dec. 2003.
38. Junji Chida, Hiroki Nagai, Yasuo Maeda and Keisuke Asai :
酸素消光を利用した生体組織内におけるモルフォゲン分布パターンの可視化法の確立,
第31回 可視化情報学会, Nov. 2003.
39. Junji Chida, Hitomi Yamaguchi, Aiko Amagai and Yasuo Maeda :
分化・パターン形成の制御における mtDNA の必要性,
第15回 日本植物形態学会大会, Sep. 2003.
40. Junji Chida, Hitomi Yamaguchi, Aiko Amagai and Yasuo Maeda :
Dictyostelium discoideum の分化・形態形成における mtDNA の多面的な機能,
第67回 日本植物学会大会, Sep. 2003.
41. Junji Chida, Aiko Amagai, Masashi Tanaka and Yasuo Maeda :
発生研究モデルとしての細胞性粘菌ミトコンドリアゲノム欠損株の有用性,
第2回 日本ミトコンドリア学会, Dec. 2002.
42. Junji Chida, Aiko Amagai, Masashi Tanaka and Yasuo Maeda :
発生研究のシステムとしての細胞性粘菌 mt ゲノム欠損株の有用性,
第15回 日本植物学会支部大会, Nov. 2002.

Et cetera, Workshop:

1. Junji Chida, Hideyuki Hara and Suehiro Sakaguchi :
肺で発現する正常プリオン蛋白質の機能解析,
第32回中国四国ウイルス研究会, Jun. 2017.
2. Junji Chida, Hiroki Nagai, Koki Takiura, Aiko Amagai, Yasuo Maeda and Keisuke Asai :
粘菌の細胞集団における酸素圧の部域的差異,
第8回 細胞性粘菌研究会, Nov. 2005.
3. Junji Chida, Masashi Tanaka, Aiko Amagai and Yasuo Maeda :
細胞性粘菌を用いた研究で明らかになったミトコンドリアの多彩な機能,
第8回 細胞性粘菌研究会, Nov. 2005.
4. Junji Chida, Hitomi Yamaguchi, Aiko Amagai and Yasuo Maeda :
Mitochondrial genome DNA (mtDNA) is required for normal development of Dictyostelium discoideum cells.,
第6回 細胞性粘菌研究会, Mar. 2004.
5. Takahiro Morio, Chad Shaw, Junji Chida, Nancy Van Driessche, Mariko Katoh, Miroslava Ibarra, Sujata Sharma, Engi Okyay, Aiko Amagai, Hideko Urushihara, Adam Kusupa, Yasuo Maeda and Gad Shaulsky :
細胞性粘菌の細胞周期における遺伝子発現プロファイルの解析,
第5回 細胞性粘菌研究会, Mar. 2003.

Patent:

1. Suehiro Sakaguchi and Junji Chida : 非アルコール性脂肪肝炎を治療または予防するための医薬組成物, (Jan. 2022), (Aug. 2023), 2022-008773 (Jan. 2022).
2. Suehiro Sakaguchi and Junji Chida : 抗プリオン蛋白質抗体とその用途, (Apr. 2015), 2015-077742 (Apr. 2015).
3. 石田 晃彦, 花田 祐紀, Hiroshi Kido, Junji Chida, 谷 博文 and 渡慶次 学 : 血液検体のATP測定方法及びキット, 2013-174874 (Aug. 2013), 2015-42156 (Mar. 2015), 2013-174874 (Aug. 2013).
4. Hiroshi Kido, Junji Chida, 山根 一彦, 大村 智, 中野 洋文, 山地 賢三郎 and 山本 剛 : PDK4阻害剤及びその利用, (Apr. 2012), WO2013/153821 A1 (Oct. 2013), PCT/JP2013/002500 (Apr. 2013).
5. Hiroshi Kido, Masaji Nishimura and Junji Chida : 病気の重症度の検査方法, PCT/JP2011/002979 (May 2011), WO2011/152012 A1 (Dec. 2011), 2010-125354 (May 2010).
6. Hiroshi Kido, Junji Chida, 塙 雅明, 山本 善一, 井 紀孝 and 角田 健司 : インフルエンザの治療剤または予防剤, 2011-15729 (Jan. 2011), WO2012/101846 (Aug. 2012), PCT/JP2011/067321 (Jul. 2011).
7. Hiroshi Kido, Junji Chida and 武井 恒知 : ヌクレオチドの抽出方法, PCT/JP2009/51364 (Jan. 2009), WO 2009/096429 A1 (Aug. 2009), 2008-017863 (Jan. 2008).

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • Studies of prion pathogenesis and non-prion pathogens for preventative and therapeutic development against prion diseases (Project/Area Number: 23K27489 )
  • Development of causative therapies for emerging infectious diseases targeting host inflammatory macrophages (Project/Area Number: 22K08600 )
  • Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice (Project/Area Number: 19K08930 )
  • Elucidation of the pathogenic mechanism and screening of therapeutic compounds in prion disease (Project/Area Number: 19H03548 )
  • Analysis of mechanism of a novel cancersuressor derived from microorganism (Project/Area Number: 16K15130 )
  • Prion protein protects mice from lethal infection with influenza A virus (Project/Area Number: 16K10029 )
  • Elucidation of the vesicular trafficking mechanism for prion propagation on the basis of our previous findings of the disturbed vesicular trafficking in prion disease (Project/Area Number: 26293212 )
  • Elucidation of molecular pathogenesis of influenza virus-associated encephalopathy using Prnp0/0 mice. (Project/Area Number: 25461596 )
  • New target and therapeutic approach to influenza virus-induced multiple organ failure (Project/Area Number: 23791180 )
  • Studies on real-time biomarker of illness severity inthe patients of critical illness and development of the diagnosis machine (Project/Area Number: 23659846 )
  • The analysis of host response determining the severe influenza and HIV infection. (Project/Area Number: 23591477 )
  • Elucidation of the molecular mechanisms of influenza-associated encephalopathy due to disorder of ATP generation in mitochondria (Project/Area Number: 21790992 )
  • Development of new therapeutics for a highly pathogenic influenza virus infection by inhibition of virus entry and multiplication (Project/Area Number: 21249061 )
  • Elucidation of the molecular mechanism of influenza-associated encephalopathy due to disorder of ATP generation in mitochondria (Project/Area Number: 19790724 )
  • Search by Researcher Number (20437651)