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Tokushima UniversityResearch ClustersResearch Clusters2201002 慢性炎症の理解と操作
Tokushima UniversityGraduate School of Pharmaceutical SciencesPharmacy
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Field of Study

Biochemistry

Subject of Study

遺伝性神経変性疾患

Book / Paper

Book:

1. 斎藤 充, 高田 潤一, Shinjiro Takata, 竹内 靖博, 茶木 修, 中村 幸男, 荻野 浩, 三浦 雅一, 元木 由美, 森脇 好乃美, 森脇 笙, Tetsuo Yamazaki and 吉村 典子 :
骨代謝マーカーハンドブック,
Medical Review Co.,Ltd, Tokyo, Oct. 2022.
2. 竹島 浩, Tetsuo Yamazaki, 池田 篤史 and 輿水 崇鏡 :
医歯薬系学生のためのillustrated基礎生命科学,
京都廣川書店, 2008.

Academic Paper (Judged Full Paper):

1. Misaki Onodera, Saori Tsujimoto, Syusuke Doi, Arisa Yamashita, Tetsuo Yamazaki, Takao Makifuchi and Tetsuya Inazu :
p.Asn77Lys homozygous CLN6 mutation in two unrelated Japanese patients with Kufs disease, an adult onset neuronal ceroid lipofuscinosis.,
Clinica Chimica Acta, Vol.523, No.21, 191-195, 2021.
(DOI: 10.1016/j.cca.2021.09.021,   PubMed: 34597687)
2. Yuki Shiro, Arisa Yamashita, Kana Watanabe and Tetsuo Yamazaki :
CLN6's luminal tail-mediated functional interference between CLN6 mutants as a novel pathomechanism for the neuronal ceroid lipofuscinoses.,
Biomedical Research, Vol.42, No.4, 129-138, 2021.
(Tokushima University Institutional Repository: 116174,   DOI: 10.2220/biomedres.42.129,   PubMed: 34380921)
3. Arisa Yamashita, Yuki Shiro, Yuri Hiraki, Takatoshi Yujiri and Tetsuo Yamazaki :
Implications of graded reductions in CLN6's anti-aggregate activity for the development of the neuronal ceroid lipofuscinoses.,
Biochemical and Biophysical Research Communications, Vol.525, No.4, 883-888, 2020.
(Tokushima University Institutional Repository: 114612,   DOI: 10.1016/j.bbrc.2020.03.019,   PubMed: 32171521)
4. Arisa Yamashita, Yuri Hiraki and Tetsuo Yamazaki :
Identification of CLN6 as a molecular entity of endoplasmic reticulum-driven anti-aggregate activity,
Biochemical and Biophysical Research Communications, Vol.487, No.4, 917-922, 2017.
(Tokushima University Institutional Repository: 111526,   DOI: 10.1016/j.bbrc.2017.05.002,   PubMed: 28476624)
5. Shin-ichiro Yamamto, Arisa Yamashita, Naokatu Arakaki, Hisao Nemoto and Tetsuo Yamazaki :
Prevention of aberrant protein aggregation by anchoring the molecular chaperone B-crystallin to the endoplasmic reticulum.,
Biochemical and Biophysical Research Communications, Vol.455, No.3-4, 241-245, 2014.
(DOI: 10.1016/j.bbrc.2014.10.151,   PubMed: 25449278)
6. Shin-ichiro Yamamto, Tetsuo Yamazaki, Shinji Komazaki, Takeshi Yamashita, Masako Osaki, Masaya Matsubayashi, Hiroyasu Kidoya, Nobuyuki Takakura, Daiju Yamazaki and Sho Kakizawa :
Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.,
Developmental Biology, Vol.393, No.1, 33-43, 2014.
(DOI: 10.1016/j.ydbio.2014.06.024,   PubMed: 25009997)
7. Naokatu Arakaki, Arisa Yamashita, Shingo Niimi and Tetsuo Yamazaki :
Involvement of reactive oxygen species in osteoblastic differentiation of MC3T3-E1 cells accompanied by mitochondrial morphological dynamics.,
Biomedical Research, Vol.34, No.3, 161-166, 2013.
(DOI: 10.2220/biomedres.34.161,   PubMed: 23782750,   Elsevier: Scopus)
8. Arisa Yamashita, Tatsuya Taniwaki, Yuka Kaikoi and Tetsuo Yamazaki :
Protective role of the endoplasmic reticulum protein mitsugumin23 against ultraviolet C-induced cell death.,
FEBS Letters, Vol.587, No.9, 1299-1303, 2013.
(DOI: 10.1016/j.febslet.2013.03.024,   PubMed: 23542032,   Elsevier: Scopus)
9. Dale Ty Troutman, Wei Hu, Stephanie Fulenchek, Tetsuo Yamazaki, Tomohiro Kurosaki, Fernando J Bazan and Chandrashekhar Pasare :
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt.,
Proceedings of the National Academy of Sciences of the United States of America, Vol.109, No.1, 273-278, 2011.
(DOI: 10.1073/pnas.1118579109,   PubMed: 22187460)
10. Sungwon Song, Claude Chew, Benjamin M. Dale, Daniel Traum, James Peacock, Tetsuo Yamazaki, Raphael Clynes, Tomohiro Kurosaki and Steven Greenberg :
A Requirement for the p85 PI3K Adapter Protein BCAP in the Protection of Macrophages from Apoptosis Induced by Endoplasmic Reticulum Stress.,
The Journal of Immunology, Vol.187, No.2, 619-625, 2011.
(DOI: 10.4049/jimmunol.0903425,   PubMed: 21685326)
11. Kita Toshiyuki, Nishida Hana, Niimi Shingo, Hirofumi Shibata, Tetsuo Yamazaki and Naokatu Arakaki :
Role of cell surface H+-ATP synthase on adipocyte differentiation.,
Inflammation and Regeneration, Vol.30, No.5, 425-427, 2010.
(DOI: 10.2492/inflammregen.30.425,   CiNii: 1390001205257545984)
12. Tetsuo Yamazaki, Nozomi Sasaki, Miyuki Nishi and Hiroshi Takeshima :
Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23.,
Biochemical and Biophysical Research Communications, Vol.392, No.2, 196-200, 2010.
(DOI: 10.1016/j.bbrc.2010.01.013,   PubMed: 20060811)
13. Daiju Yamazaki, Shinji Komazaki, Hiroki Nakanishi, Aya Mishima, Miyuki Nishi, Masayuki Yazawa, Tetsuo Yamazaki, Ryo Taguchi and Hiroshi Takeshima :
Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation.,
Development, Vol.136, No.14, 2355-2361, 2009.
(DOI: 10.1242/dev.036798,   PubMed: 19515693)
14. Haruko Masumiya, Yasuhide Asaumi, Miyuki Nishi, Susumu Minamisawa, Satomi Adachi-Akahane, Morikatsu Yoshida, Kenji Kangawa, Kenta Ito, Yutaka Kagaya, Teruyuki Yanagisawa, Tetsuo Yamazaki, Jianjie Ma and Hiroshi Takeshima :
Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes.,
Channels, Vol.3, No.1, 6-11, 2009.
(DOI: 10.4161/chan.3.1.7571,   PubMed: 19202355,   Elsevier: Scopus)
15. Alexander W. MacFarlane, Tetsuo Yamazaki, Min Fang, Luis J. Sigal, Tomohiro Kurosaki and Kerry S. Campbell :
Enhanced NK-cell development and function in BCAP-deficient mice.,
Blood, Vol.112, No.1, 131-140, 2008.
(DOI: 10.1182/blood-2007-08-107847,   PubMed: 18337558)
16. Yuichi Aiba, Megumi Kameyama, Tetsuo Yamazaki, Thomas F. Tedder and Tomohiro Kurosaki :
Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase.,
Blood, Vol.111, No.3, 1497-1503, 2007.
(DOI: 10.1182/blood-2007-08-109769,   PubMed: 18025150)
17. Atsushi Ikeda, Taisuke Miyazaki, Sho Kakizawa, Yasushi Okuno, Soken Tsuchiya, Akira Myomoto, Shin-ya Saito, Tetsuji Yamamoto, Tetsuo Yamazaki, Masamitsu Iino, Gozoh Tsujimoto, Masahiko Watanabe and Hiroshi Takeshima :
Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins.,
Biochemical and Biophysical Research Communications, Vol.363, No.3, 835-839, 2007.
(DOI: 10.1016/j.bbrc.2007.09.062,   PubMed: 17904530)
18. Tetsuo Yamazaki, Nozomi Sasaki, Miyuki Nishi, Daiju Yamazaki, Atsushi Ikeda, Yasushi Okuno, Shinji Komazaki and Hiroshi Takeshima :
Augmentation of drug-induced cell death by ER protein BRI3BP.,
Biochemical and Biophysical Research Communications, Vol.362, No.4, 971-975, 2007.
(DOI: 10.1016/j.bbrc.2007.08.082,   PubMed: 17765869)
19. Miao Zhang, Tetsuo Yamazaki, Masayuki Yazawa, Susan Treves, Miyuki Nishi, Machiko Murai, Eisuke Shibata, Francesco Zorzato and Hiroshi Takeshima :
Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum.,
Cell Calcium, Vol.42, No.1, 83-90, 2007.
(DOI: 10.1016/j.ceca.2006.11.009,   PubMed: 17204322)
20. Yuichi Aiba, Tetsuo Yamazaki, Takaharu Okada, Kumiko Gotoh, Hideki Sanjo, Masato Ogata and Tomohiro Kurosaki :
BANK negatively regulates Akt activation and subsequent B cell responses.,
Immunity, Vol.24, No.3, 259-268, 2006.
(DOI: 10.1016/j.immuni.2006.01.002,   PubMed: 16546095)
21. Tetsuo Yamazaki and Tomohiro Kurosaki :
Contribution of BCAP to maintenance of mature B cells through c-Rel.,
Nature Immunology, Vol.4, No.8, 780-786, 2003.
(DOI: 10.1038/ni949,   PubMed: 12833156)
22. Stephen C. Bunnell, David I. Hong, Julia R. Kardon, Tetsuo Yamazaki, C Jane McGlade, Valarie A. Barr and Lawrence E. Samelson :
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies.,
The Journal of Cell Biology, Vol.158, No.7, 1263-1275, 2002.
(DOI: 10.1083/jcb.200203043,   PubMed: 12356870)
23. Tetsuo Yamazaki, Kristien Zaal, Dale Hailey, John Presley, Jennifer Lippincott-Schwartz and Lawrence E. Samelson :
Role of Grb2 in EGF-stimulated EGFR internalization.,
Journal of Cell Science, Vol.115, No.Pt 9, 1791-1802, 2002.
(PubMed: 11956311)
24. Tetsuo Yamazaki, Kiyoshi Takeda, Kumiko Gotoh, Hiroshi Takeshima, Shizuo Akira and Tomohiro Kurosaki :
Essential immunoregulatory role for BCAP in B cell development and function.,
The Journal of Experimental Medicine, Vol.195, No.5, 535-545, 2002.
(DOI: 10.1084/jem.20011751,   PubMed: 11877477,   Elsevier: Scopus)
25. Tetsuo Yamazaki, Y Hamano, H Tashiro, K Itoh, H Nakano, S Miyatake and T Saito :
CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells.,
The Journal of Biological Chemistry, Vol.274, No.26, 18173-18180, 1999.
(PubMed: 10373416)
26. E L Samelson, C S Bunnell, P R Trible, Tetsuo Yamazaki and W Zhang :
Studies on the adapter molecule LAT.,
Cold Spring Harbor Symposia on Quantitative Biology, Vol.64, 259-263, 1999.
(PubMed: 11232294)
27. J Sloan-Lancaster, J Presley, J Ellenberg, Tetsuo Yamazaki, J Lippincott-Schwartz and E L Samelson :
ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation.,
The Journal of Cell Biology, Vol.143, No.3, 613-624, 1998.
(DOI: 10.1083/jcb.143.3.613,   PubMed: 9813084)
28. Y S Park, S Ueda, H Ohno, Y Hamano, M Tanaka, T Shiratori, Tetsuo Yamazaki, H Arase, N Arase, A Karasawa, S Sato, B Ledermann, Y Kondo, K Okumura, C Ra and T Saito :
Resistance of Fc receptor- deficient mice to fatal glomerulonephritis.,
The Journal of Clinical Investigation, Vol.102, No.6, 1229-1238, 1998.
(DOI: 10.1172/JCI3256,   PubMed: 9739057)
29. Tetsuo Yamazaki, H Arase, S Ono, H Ohno, H Watanabe and T Saito :
A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3 zeta-deficient mice.,
The Journal of Immunology, Vol.158, No.4, 1634-1640, 1997.
(PubMed: 9029099)
30. H Nakano, Tetsuo Yamazaki, S Miyatake, N Nozaki, A Kikuchi and T Saito :
Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex.,
The Journal of Biological Chemistry, Vol.271, No.11, 6483-6489, 1996.
(PubMed: 8626450)
31. S Miyatake, H Nakano, Y S Park, Tetsuo Yamazaki, K Takase, H Matsushime, A Kato and T Saito :
Induction of G1 arrest by down-regulation of cyclin D3 in T cell hybridomas.,
The Journal of Experimental Medicine, Vol.182, No.2, 401-408, 1995.
(PubMed: 7629502)
32. H Nakano, Tetsuo Yamazaki, M Ikeda, H Masai, S Miyatake and T Saito :
Purification of glutathione S-transferase fusion proteins as a non-degraded form by using a protease-negative E. coli strain, AD202.,
Nucleic Acids Research, Vol.22, No.3, 543-544, 1994.
(DOI: 10.1093/nar/22.3.543,   PubMed: 8127699)

Academic Paper (Unrefereed Paper):

1. Shiro Yuki and Tetsuo Yamazaki :
CTSD integrity in the endoplasmic reticulum is required for CLN6's anti-aggregate activity,
Molecular Genetics and Metabolism, Vol.141, No.2, 108044, 2024.
(DOI: https://doi.org/10.1016/j.ymgme.2023.108044)

Review, Commentary:

1. Shinjiro Takata, 森脇 好乃美, 森脇 笙, 馬渕 勝, 岩田 織江, 国重 裕二, 澤田 侑樹, 吉兼 麻木子, 宮崎 達志, 近藤 梨恵子, 渡邊 典子 and Tetsuo Yamazaki :
運動療法とロボティクスの動向―近未来予測―. 筋ジストロフィーの診療・リハビリテーション医療の動向,
Journal of Clinical Rehabilitation, Vol.31, No.2, 134-142, Jan. 2022.
(CiNii: 1520294429647353216)
2. Shinjiro Takata, 森脇 笙, Yuka Ueda, 元木 由美, 森脇 好乃美, Tetsuo Yamazaki, 田村 英司, 住友 祐介, 柿本 直子 and 海部 忍 :
大腿骨近位部骨折回避のための転倒予防の重要性と具体策 : サルコペニアとフレイルからのアプローチを含む (第47回 日本股関節学会学術集会 シンポジウム2 大腿骨近位部骨折の予防と治療における新たな知見と進歩を目指して),
The Journal of Japan Osteoporosis Society, Vol.7, No.2, 358-363, Feb. 2021.
(CiNii: 1523951030943292672)
3. Daiju Yamazaki, Tetsuo Yamazaki and Hiroshi Takeshima :
Physiological functions of TRIC channels,
Seikagaku, Vol.81, No.11, 1004-1008, Nov. 2009.
(PubMed: 19999584,   CiNii: 1520009407923877120)
4. Daiju Yamazaki, Tetsuo Yamazaki and Hiroshi Takeshima :
New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.,
Pharmacology & Therapeutics, Vol.121, No.3, 265-272, Dec. 2008.
(DOI: 10.1016/j.pharmthera.2008.11.004,   PubMed: 19095005)
5. 池田 篤史, Tetsuo Yamazaki and 竹島 浩 :
Molecular basis of ryanodine receptor-mediated Ca[2+] release,
Tanpakushitsu Kakusan Koso, Vol.52, No.15, 1965-1972, Dec. 2007.
(CiNii: 1524232505734459136)
6. Atsushi Ikeda, Tetsuo Yamazaki and Hiroshi Takeshima :
[Molecular basis of ryanodine receptor-mediated Ca2+ release],
Tanpakushitsu Kakusan Koso, Vol.52, No.15, 1965-1972, Dec. 2007.
(PubMed: 18064887)
7. Tetsuo Yamazaki :
B細胞の分化・機能発現とBCAP,
Clinical Immunology, Vol.43, No.4, 483-486, Apr. 2005.
(CiNii: 1521136280863139072)
8. Tetsuo Yamazaki :
B細胞の分化・機能発現とBCAP,
Clinical Immunology, Vol.43, No.4, 483-486, Apr. 2005.
9. Tetsuo Yamazaki :
B細胞の最終分化を決定するBCAPの核内転写因子c-Rel制御 (免疫細胞のシグナル伝達),
免疫 2006, Vol.2005, 165-170, 2005.
(CiNii: 1520854805196959488)
10. Tetsuo Yamazaki :
B細胞の最終分化を決定するBCAPの核内転写因子c-Rel制御 (免疫細胞のシグナル伝達),
免疫, Vol.2005, 165-170, 2005.
11. Tetsuo Yamazaki :
成熟B細胞の維持におけるB cell adaptor for PI3 kinase(BCAP)の役割,
Clinical Immunology, Vol.41, No.5, 574-577, May 2004.
(CiNii: 1520573330734682624)
12. Tetsuo Yamazaki :
成熟B細胞の維持におけるB cell adaptor for PI3 kinase(BCAP)の役割,
Clinical Immunology, Vol.41, No.5, 574-577, May 2004.
13. Tetsuo Yamazaki and 黒崎 知博 :
B細胞シグナルにおけるアダプター分子の機能発現機構 (B細胞シグナル伝達),
Journal of Clinical and Experimental Medicine, Vol.207, No.3, 174-178, Oct. 2003.
(CiNii: 1521417755819914624)
14. Tetsuo Yamazaki :
解説 B細胞の分化・機能発現とBCAP,
Clinical Immunology, Vol.39, No.2, 230-235, Feb. 2003.
(CiNii: 1521417755421346432)
15. Tetsuo Yamazaki and 黒崎 知博 :
新規アダプター分子BCAPによる免疫制御機構 (免疫研究の最前線--高次複雑系免疫システムの包括的理解をめざして) -- (リンパ球活性化・細胞死のシグナル制御),
Tanpakushitsu Kakusan Koso, Vol.47, No.16, 2242-2247, Dec. 2002.
(CiNii: 1523669554538206592)
16. Tetsuo Yamazaki and Tomohiro Kurosaki :
[Immunoregulatory role for BCAP in B cell development and function],
Tanpakushitsu Kakusan Koso, Vol.47, No.16 Suppl, 2242-2247, Dec. 2002.
(PubMed: 12518443)
17. Tetsuo Yamazaki :
Interview about BCAP,
Modern Aspects of Immunobiol., Vol.2, 154, Mar. 2002.
18. Tetsuo Yamazaki and 斉藤 隆 :
T細胞抗原受容体を介するシグナル伝達 (特集 免疫系における情報伝達とその異常),
The Medical Frontline, Vol.52, No.4, 759-767, Apr. 1997.
(CiNii: 1523669555184799616)
19. Tetsuo Yamazaki and 斉藤 隆 :
TCRシグナルによるT細胞選択の調節 (免疫生物学),
免疫(1996-97), No.1996, 101-111, Aug. 1996.
(CiNii: 1521136280220425088)
20. Tetsuo Yamazaki and 斉藤 隆 :
T細胞抗原受容体スーパーファミリー,
Science of the Living Body, Vol.46, No.5, 556-560, Oct. 1995.
(DOI: 10.11477/mf.2425901000)

Proceeding of International Conference:

1. Yuki Shiro and Tetsuo Yamazaki :
CTSD integrity in the endoplasmic reticulum is required for CLN6's anti-aggregate activity,
The 20th annual WORLDSymposium 2024, San Diego, Feb. 2024.
2. Yuki Shiro and Tetsuo Yamazaki :
Novel insight into the compound heterozygosity-driven CLN6 disease pathomechanism,
The 18th annual WORLDSymposium 2022, California, Feb. 2022.
3. Yuki Shiro and Tetsuo Yamazaki :
Contribution of functional interference between CLN6 mutants to the pathogenesis of the neuronal ceroid lipofuscinoses,
The 17th International Congress on Neuronal Ceroid Lipofuscinosis, St Louis, Oct. 2021.
4. Yuki Shiro and Tetsuo Yamazaki :
Implications of graded reductions in CLN6's anti-aggregate activity as a pathomechanism of the neuronal ceroid lipofuscinoses,
The 45th FEBS Congres, Ljubljana, Jul. 2021.
5. Yuki Shiro and Tetsuo Yamazaki :
Differential impairment of CLN6s anti-aggregate activity as a pathogenic mechanism of CLN6 disease,
17th annual WORLDSymposium 2021, Minnesota, Feb. 2021.
6. Arisa Yamashita and Tetsuo Yamazaki :
ER-driven anti-aggregate activity toward pathogenic alphaB-crystallin mutants,
The 43rd FEBS Congress, Praha, Jul. 2018.
7. Arisa Yamashita, Takamitsu Nakatsuru, Hiroki Saito, Yuri Hiraki and Tetsuo Yamazaki :
ER Manipulation: A promising therapeutic intervention for protein aggregation diseases,
The 3rd International Symposium on Regenerative Rehabilitation in Kyoto, Kyoto, Feb. 2017.
8. Tetsuo Yamazaki :
ER as a potential therapeutic target for protein aggregation disease,
The Fifth Bizan Immunology Symposium at The University of Tokushima, Tokushima, Mar. 2016.
9. Tetsuo Yamazaki :
Manipulation of the ER: a novel strategy against protein desposition disease.,
The Fourth Bizan Immunology Symposium at The University of Tokushima, Tokushima, Jan. 2015.

Proceeding of Domestic Conference:

1. Yuki Shiro and Tetsuo Yamazaki :
Cathepsin Dは小胞体内腔でCLN6の凝集抑制能を支える,
第21回四国免疫フォーラム, Jun. 2023.
2. Yuki Shiro, Syouichi Katayama and Tetsuo Yamazaki :
CLN10 A58V mutant interferes with the ER-driven anti-aggregate activity,
日本薬学会第143年会(北海道), Mar. 2023.
3. Kana Watanabe, Yuki Shiro, Syouichi Katayama and Tetsuo Yamazaki :
CLN6s C-terminal mutants evaluation of the anti-aggregate activity and protein stability as a cause of CLN6 disease,
日本薬学会第143年会(北海道), Mar. 2023.
4. Syouichi Katayama, Yuki Shiro and Tetsuo Yamazaki :
Role of cyclin-dependent kinase-like 5 during neuronal differentiation in vitro,
日本薬学会第143年会(北海道), Mar. 2023.
5. Yuki Shiro and Tetsuo Yamazaki :
CLN10変異体のもつ凝集抑止機能と疾患の関連性,
超異分野学会 大阪大会2022, Aug. 2022.
6. Yuki Shiro and Tetsuo Yamazaki :
Cathepsin Dによる小胞体膜微小環境の制御機構解明,
第20回四国免疫フォーラム, Jun. 2022.
7. Syouichi Katayama, 城 祐己 and Tetsuo Yamazaki :
Establishment of a method for detecting the activity of cyclin-dependent kinase-like 5 in cellulo,
日本薬学会第142年会(愛知), Mar. 2022.
8. Yuki Shiro and Tetsuo Yamazaki :
CLN6-CLN10 complex regulates ER-driven anti-aggregate activity,
日本薬学会第142年会, Mar. 2022.
9. Yuki Shiro and Tetsuo Yamazaki :
vPreventing neurodegenerative disease through ER-driven anti-aggregate activity,
超異分野学会 東京大会2022, Mar. 2022.
10. Yuki Shiro and Tetsuo Yamazaki :
小胞体膜近傍タンパク質複合体の障害による凝集体蓄積疾患の発症メカニズム,
第112回蔵本免疫懇話会, Jan. 2022.
11. Yuki Shiro and Tetsuo Yamazaki :
稀少疾患CLN6病の発病予測システムの開発に向けて,
超異分野学会 香川フォーラム2021, Dec. 2021.
12. Syouichi Katayama, Yuki Shiro and Tetsuo Yamazaki :
Establishment of a method for detecting the substrate phosphorylation activity of cyclin-dependent kinase-like 5 using an artificial substrate,
第44回日本分子生物学会, Dec. 2021.
13. Yuki Shiro and Tetsuo Yamazaki :
Molecular mechanisms underlying the loss of anti-aggregate activity with mutations in CLN6's C-terminal region,
第44回日本分子生物学会, Dec. 2021.
14. Yuki Shiro and Tetsuo Yamazaki :
小胞体を中心とするタンパク質恒常性を支える分子メカニズムの解明,
第4回 kenQ-Pitch Osaka, Nov. 2021.
15. Syouichi Katayama, Yuki Shiro and Tetsuo Yamazaki :
Phos-tag SDS-PAGEを利用したcyclin-dependent kinase-like 5の基質リン酸化検出法の開発,
第60回日本薬学会中国四国支部学術大会, Oct. 2021.
16. Kana Watanabe, Yuki Shiro and Tetsuo Yamazaki :
複合ヘテロ接合型CLN6病における凝集抑止活性を消失させる新たなメカニズムの解明,
第60回日本薬学会中国四国支部学術大会, Oct. 2021.
17. Yuki Shiro and Tetsuo Yamazaki :
Examination of clinical features about compound heterozygous CLN6 disease with the CLN6 P299L missense mutant,
日本人類遺伝学会 第66回大会, Oct. 2021.
18. Yuki Shiro and Tetsuo Yamazaki :
CLN6 missense mutant (P299L) was selectively vulnerable to the frameshift mutant (S132fs),
日本遺伝学会 第93回大会, Sep. 2021.
19. Yuki Shiro and Tetsuo Yamazaki :
凝集体難病予防に向けた小胞体膜タンパク質品質管理機構の解明,
第20回次世代を担う若手ファーマ・バイオフォーラム2021, Aug. 2021.
20. Yuki Shiro and Tetsuo Yamazaki :
小胞体膜を取り巻く相互作用分子の可能性,
第2回 kenQ-Pitch Osaka, Aug. 2021.
21. Yuki Shiro and Tetsuo Yamazaki :
凝集抑止活性を指標とした複合ヘテロ接合型CLN6病の発症メカニズム検討,
第61回日本先天異常学術集会, Aug. 2021.
22. Yuki Shiro and Tetsuo Yamazaki :
小胞体膜に備わる凝集抑止機能の制御メカニズム解明,
第1回 kenQ-Pitch Osaka, Jun. 2021.
23. Yuki Shiro and Tetsuo Yamazaki :
複合ヘテロ接合型CLN6病における凝集抑止機能の制御メカニズム解明,
第19回四国免疫フォーラム, Jun. 2021.
24. Yuki Shiro and Tetsuo Yamazaki :
lucidation of the pathomechanism of CLN6 disease,
超異分野学会 大阪大会2021, Apr. 2021.
25. Yuki Shiro and Tetsuo Yamazaki :
複合ヘテロ接合型CLN6病の原因として見出した抗凝集体活性の喪失,
日本薬学会第141年会, Mar. 2021.
26. Syouichi Katayama, Yuki Shiro and Tetsuo Yamazaki :
Establishment of a method for detecting the activity of cyclin-dependent kinase-like 5 in cellulo,
日本薬学会第142年会, Mar. 2021.
27. Yuki Shiro and Tetsuo Yamazaki :
Employ the ER membrane toward preventing aggregate formation,
第10回超異分野学会, Mar. 2021.
28. Yuki Shiro and Tetsuo Yamazaki :
CLN6変異による抗凝集体活性の喪失とCLN6病発症の関係,
第59回日本薬学会中国四国支部学術大会, Dec. 2020.
29. Yuki Shiro, Arisa Yamashita, Yuri Hiraki, Takatoshi Yujiri and Tetsuo Yamazaki :
Defects in ER-driven anti-aggregate activity as a cause of CLN6 disease,
稀少疾患カンファランス, Aug. 2019.
30. Tetsuo Yamazaki :
小胞体膜微小環境病としての神経セロイドリポフスチン症,
立命館大学 稀少疾患プロジェクト オープンセミナー, Jun. 2019.
31. Arisa Yamashita, Yuri Hiraki and Tetsuo Yamazaki :
小胞体マニピュレーションの汎用性とその分子基盤,
第17回 四国免疫フォーラム, Jun. 2018.
32. Tetsuo Yamazaki :
タンパク質凝集体難病の克服に向けた小胞体操作法の開発,
立命館大学 稀少疾患プロジェクト オープンセミナー, Jun. 2017.
33. Arisa Yamashita, Yuri Hiraki and Tetsuo Yamazaki :
小胞体マニピュレーションがもたらす抗凝集体活性の分子基盤,
第16回 四国免疫フォーラム, Jun. 2017.
34. Tetsuo Yamazaki :
凝集体難病の克服に向けた小胞体操縦法,
福井大学医学系研究科 第567回学内セミナー (大学院セミナー), Jan. 2017.
35. Arisa Yamashita and Tetsuo Yamazaki :
タンパク質凝集体難病の克服に向けた小胞体操作の分子基盤,
第15回 四国免疫フォーラム, Jun. 2016.
36. Arisa Yamashita and Tetsuo Yamazaki :
小胞体を標的とした凝集体難病治療法開発,
第54回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, Oct. 2015.
37. Arisa Yamashita and Tetsuo Yamazaki :
ER-based therapeutic strategies toward protein deposition diseases,
第14回 四国免疫フォーラム, Jun. 2015.
38. Shin-ichiro Yamamto and Tetsuo Yamazaki :
A role of the ER protein calumin in the protein quality control system,
第53回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, Nov. 2014.
39. 智子 中西, Keisuke Ishizawa, Shinji Abe, Mari Nakase, Hirofumi Shibata, Chiemi Sato, Naokatu Arakaki, Youichi Sato, Naoshi Yamazaki, Jiro Kasahara, Mami Azuma, Tetsuo Yamazaki, Aiko Yamauchi, Yoshiharu Takiguchi and Koichiro Tsuchiya :
Study of the method for development of case-problem solving abilities through advanced practice and the results that have been achieved,
日本薬学会第134年会, Mar. 2014.
40. 智子 中西, Keisuke Ishizawa, Shinji Abe, Mari Nakase, Hirofumi Shibata, Chiemi Sato, Naokatu Arakaki, Youichi Sato, Naoshi Yamazaki, Jiro Kasahara, Mami Azuma, Tetsuo Yamazaki, Aiko Yamauchi, Yoshiharu Takiguchi and Koichiro Tsuchiya :
Study of the method for development of case-problem solving abilities through advanced practice and the results that have been achieved,
第52回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Oct. 2013.
41. Hirotaka Kira, Arisa Yamashita, Naoya Yamanaka, Kazuhiro Furukawa, Tetsuo Yamazaki, Tatsuhiro Ishida, Hiroshi Kiwada and Noriaki Minakawa :
ケミカルツールを用いたsiRNA-タンパク質間の相互作用様式解明,
第133年会日本薬学会, Mar. 2013.
42. Arisa Yamashita and Tetsuo Yamazaki :
小胞体タンパク質EPIGは紫外線照射による細胞死を抑制する,
第51回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, Nov. 2012.
43. Munekazu Komada, Naokatu Arakaki and Tetsuo Yamazaki :
ミトコンドリア由来のROSシグナルは骨芽細胞の分化を誘導する,
第51回日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, Nov. 2012.
44. Eri Hondoh, Shunsuke Masui and Tetsuo Yamazaki :
小胞体タンパク質EPIGの紫外線応答における役割,
第50回 日本薬学会・日本薬剤師会・日本病院薬剤師会 中国四国支部学術大会, Nov. 2011.
45. Tetsuo Yamazaki :
DNA損傷応答を規定する小胞体のシグナル特性,
平成23年度第3回革新的特色研究シンポジウム「分子イメージング手法を導入した免疫疾患克服の革新的研究」, Nov. 2011.
46. Tetsuo Yamazaki :
遺伝情報システムと免疫システムのクロストーク,
平成22年度第3回革新的特色研究シンポジウム「分子イメージング手法を導入した免疫疾患克服の革新的研究」, Nov. 2010.
47. Keisuke Ishizawa, 中西 智子, Hirofumi Shibata, Shinji Abe, Mayumi Sugimura, Chieko Okumura, Yoshiyuki Yoshimura, Youichi Sato, Naokatu Arakaki, Kazuyoshi Kawazoe, Mami Azuma, Koichiro Tsuchiya, Aiko Yamauchi, Tetsuo Yamazaki and Kazuo Minakuchi :
徳島大学における薬学部・薬剤部連携による病院実務実習の実践,
第20回日本医療薬学会年会, Nov. 2010.
48. 渡邉 美穂, Hirofumi Shibata, 上松 卓, 伏谷 秀治, Shinji Abe, Kazuyoshi Kawazoe, Tetsuo Yamazaki and Kazuo Minakuchi :
病院施設のATP拭き取り検査と細菌汚染状況調査,
第49回 日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会, Nov. 2010.
49. Tetsuo Yamazaki :
小胞体のシグナル特性から免疫へ,
免疫シグナルシンポジウム, Oct. 2010.
50. Shunsuke Masui and Tetsuo Yamazaki :
小胞体タンパク質MG23によるDNA損傷誘導性細胞死の促進,
第117回 日本薬理学会近畿部会, Jul. 2010.
51. Keisuke Ishizawa, Kazuyoshi Kawazoe, Mami Azuma, Koichiro Tsuchiya, Aiko Yamauchi, Tetsuo Yamazaki, Kazuo Minakuchi, 智子 中西, Hirofumi Shibata, Shinji Abe, Mayumi Sugimura, Chieko Okumura, Yoshiyuki Yoshimura, Youichi Sato and Naokatu Arakaki :
P1-571 徳島大学における薬学部・薬剤部連携による病院実務実習の実践(一般演題 ポスター発表,薬学教育(実務実習),臨床から学び臨床へと還元する医療薬学),
The Annual Meeting of Japanese Society of Pharmaceutical Health Care and Sciences, Vol.20, No.0, 382, 2010.
(CiNii: 1390845713041900800)

Report:

1. Yoshihiko Ueno, Yosuke Seki, Satoshi Kinugawa, Hisayoshi Morioka, Akira Takahashi, Kenji Mori, Naozumi Ishimaru, Kazumi Ozaki, Tetsuo Yamazaki, Atsushi Takada, Yoshihiro Uto, Takahito Saito and Maiko Kamioka :
令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書,
令和4年度 徳島大学高等教育研究センターアドミッション部門 報告書, Mar. 2023.

Grants-in-Aid for Scientific Research (KAKEN Grants Database @ NII.ac.jp)

  • 重度精神発達障害の原因遺伝子CDKL5の神経細胞分化を制御する分子メカニズムの解明 (Project/Area Number: 23K05148 )
  • 小胞体膜分子CLN6の凝集抑止能を制御する分子メカニズムの解明 (Project/Area Number: 22K06146 )
  • ER manipulation-based therapeutic strategies against protein aggregation diseases (Project/Area Number: 18K07045 )
  • Development of ER-targeted therapeutics against protein aggregation diseases (Project/Area Number: 15K08404 )
  • Dvelopment of novel anti-obesity agents targeting cell-surface F1F0-ATP synthase (Project/Area Number: 24590081 )
  • MG23-mediatedcrosstalk between genetic system and immune system. (Project/Area Number: 22590359 )
  • Analysis of the regulation of organelle-generated signals by the Novel endoplasmic protein calumin (Project/Area Number: 19590267 )
  • Analysis of regulation of carcinogenesis by the BCAP-binding molecule BB1 (Project/Area Number: 17590263 )
  • アダプター分子BCAPによる発がん抑制機構の機序解明 (Project/Area Number: 16021253 )
  • アダプター分子BCAPの機能発現機序の解明 (Project/Area Number: 15790255 )
  • Quantitative and qualitative regulation of cellular signaling in immune system (Project/Area Number: 13854013 )
  • B細胞アダプター分子BLNKに結合する新規蛋白質の機能解析 (Project/Area Number: 13770165 )
  • モデルB細胞を用いた細胞増殖・細胞死制御におけるPI3K活性化の分子機構 (Project/Area Number: 13214105 )
  • マクロファージ分化・活性化における新規アダプター分子BCAPの役割 (Project/Area Number: 13016217 )
  • Search by Researcher Number (90330208)